CN106669875A - Platelet-rich plasma centrifuge tube and extraction method thereof - Google Patents
Platelet-rich plasma centrifuge tube and extraction method thereof Download PDFInfo
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- CN106669875A CN106669875A CN201710076874.9A CN201710076874A CN106669875A CN 106669875 A CN106669875 A CN 106669875A CN 201710076874 A CN201710076874 A CN 201710076874A CN 106669875 A CN106669875 A CN 106669875A
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- rich plasma
- leukocyte
- platelet rich
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- 210000004623 platelet-rich plasma Anatomy 0.000 title claims abstract description 75
- 238000000605 extraction Methods 0.000 title abstract description 12
- 210000000265 leukocyte Anatomy 0.000 claims abstract description 70
- 210000003743 erythrocyte Anatomy 0.000 claims abstract description 23
- 210000002381 plasma Anatomy 0.000 claims abstract description 20
- 210000002966 serum Anatomy 0.000 claims abstract description 19
- 238000002347 injection Methods 0.000 claims description 31
- 239000007924 injection Substances 0.000 claims description 31
- 239000007788 liquid Substances 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 12
- 230000000844 anti-bacterial effect Effects 0.000 claims description 4
- 238000000926 separation method Methods 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 2
- -1 centrifugation Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5021—Test tubes specially adapted for centrifugation purposes
- B01L3/50215—Test tubes specially adapted for centrifugation purposes using a float to separate phases
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
- B01D17/02—Separation of non-miscible liquids
- B01D17/0217—Separation of non-miscible liquids by centrifugal force
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/56—Labware specially adapted for transferring fluids
- B01L3/563—Joints or fittings ; Separable fluid transfer means to transfer fluids between at least two containers, e.g. connectors
- B01L3/5635—Joints or fittings ; Separable fluid transfer means to transfer fluids between at least two containers, e.g. connectors connecting two containers face to face, e.g. comprising a filter
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- External Artificial Organs (AREA)
- Centrifugal Separators (AREA)
Abstract
The invention relates to the field of medical devices, in particular to a platelet-rich plasma centrifuge tube and an extraction method thereof. The platelet-rich plasma centrifuge tube sequentially comprises a serum region, a platelet-rich plasma region, a leukocyte region, and an erythrocyte region from top to bottom, wherein the platelet-rich plasma region is connected with the leukocyte region through an upper through hole, and the leukocyte region is connected with the erythrocyte region through a lower through hole; an extraction hole is formed in the side wall of the leukocyte region, and the leukocyte region is provided with a three-way T-type switch corresponding to the upper through hole, the lower through hole and the extraction hole, accordingly, the upper through hole, the lower through hole and the extraction hole are in a conduction or closed state according to the needs, so that the extraction of the platelet-rich plasma centrifuge tube is relatively simple and plasma is not easily contaminated.
Description
Technical field
The present invention relates to medical instruments field, and in particular to a kind of platelet rich plasma centrifuge tube and its extracting method.
Background technology
Platelet rich plasma (PRP) can be prepared under household condition in operating room, but must be kept in centrifugal process
It is aseptic, and need to separate under the high concentration without thrombocytolysis or destruction, PRP knots prepared by different PRP extraction elements
Fruit is different, and a whole set of many devices, test tube, note is medically used during platelet rich plasma separation and Extraction is done at present
Emitter etc., be also operationally it is considerably complicated, through multiple injection, centrifugation, extract, it is very inconvenient, and easily cause
Pollute, therefore this kind of Method and kit for will be improved, and simplify whole operation step, pollution-freeization.
The content of the invention
For the deficiencies in the prior art, it is intended to solve the problems, such as that existing platelet rich plasma separation and Extraction is excessively complicated.
For achieving the above object, the present invention is adopted the following technical scheme that：
A kind of platelet rich plasma centrifuge tube, from top to bottom includes successively serum area, platelet rich plasma area, leukocyte
Area, erythrocyte area；
Connected by upper through hole between the platelet rich plasma area and leukocyte area；
Connected by lower through-hole between the leukocyte area and erythrocyte area；
The side wall in the leukocyte area is provided with drawing holes；
Correspond to the upper through hole, lower through-hole, drawing holes, the leukocyte area is provided with the T-shaped switch of threeway.
Preferably, the platelet rich plasma centrifuge tube is integral type structure, and the bottom in the serum area includes
Reverse frustoconic structure, the platelet rich plasma area is cylindrical structure, and the leukocyte area is cylindrical structure, described red thin
The top in born of the same parents area includes truncated cone-shaped structure.
Preferably, it is provided with lid at the top of the serum area.
Preferably, the lid is provided with injection orifice and passage.
Preferably, the injection orifice is provided with injection port lid, and the passage is provided with vent cap.
Preferably, the injection orifice is arranged on the central area of the lid, is provided with ventilative in the passage
Antibacterial film.
Preferably, the bottom in the erythrocyte area is provided with rotary-piston.
Preferably, the T-shaped switch of the threeway, the side wall in the leukocyte area be correspond to and is provided with the T-shaped switch of threeway
Valve.
For achieving the above object, the present invention is also adopted the following technical scheme that：
A kind of extracting method of platelet rich plasma, comprises the following steps：
The T-shaped controlled valve of threeway is rotated, through hole and lower through-hole conducting, drawing holes closing is made；
Open injection port lid, vent cap；
Blood plasma is injected into into centrifuge tube from injection orifice, then closed injection port lid, vent cap；
The centrifuge tube that will be equipped with blood plasma is put into centrifuge；
After blood plasma layering, vent cap is opened；
By the upper drawing holes of syringe connection, the T-shaped controlled valve of threeway is then rotated, make through hole and drawing holes conducting, under
Through hole is closed, then opens vent cap, and using syringe platelet rich plasma is extracted.
Preferably, it is described after blood plasma layering, after opening vent cap, comprise the following steps：
Rotate rotary-piston and liquid level on leukocyte is adjusted to into leukocyte area；
If desired for leukocyte is extracted, then liquid level on leukocyte is raised to higher than drawing holes；
Leukocyte need not be such as extracted, then liquid level on leukocyte being pushed away as little as be less than drawing holes.
A kind of platelet rich plasma centrifuge tube set forth in the present invention, its advantage is：
1) compared with prior art, a kind of platelet rich plasma centrifuge tube of the invention from top to bottom includes successively serum
Area, platelet rich plasma area, leukocyte area, erythrocyte area；By upper logical between the platelet rich plasma area and leukocyte area
Hole connects；Connected by lower through-hole between the leukocyte area and erythrocyte area；The side wall in the leukocyte area is provided with drawing holes；
Correspond to the upper through hole, lower through-hole, drawing holes, the leukocyte area is provided with the T-shaped switch of threeway, the T-shaped switch energy of threeway
It is enough to cause upper through hole, lower through-hole, drawing holes to realize following conducting or closed state：1st, upper through hole, lower through-hole conducting, drawing holes envelope
Close；2nd, upper through hole, drawing holes conducting, lower through-hole closing；3rd, upper through hole, lower through-hole, drawing holes are turned on entirely；4th, upper through hole, lower logical
Hole, drawing holes are totally-enclosed, so cause upper through hole, lower through-hole, drawing holes to realize conducting or closed state above as needed, make
The extraction of platelet rich plasma centrifuge tube is simpler, is also not easy to be contaminated blood plasma.
2) a kind of compared with prior art, the platelet rich plasma centrifugation of platelet rich plasma centrifuge tube of the invention
Manage as integral type structure, the bottom in the serum area includes reverse frustoconic structure, and the platelet rich plasma area is cylinder knot
Structure, the leukocyte area is cylindrical structure, and the top in the erythrocyte area includes truncated cone-shaped structure, is centrifuged according to whole plasm Jing
Machine separate after serum, platelet rich plasma, leukocyte, the density order from small to large of erythrocyte, by platelet rich plasma from
Heart pipe from top to bottom successively include serum area, platelet rich plasma area, leukocyte area, erythrocyte area, further according to whole plasm Jing from
Serum, platelet rich plasma, leukocyte, the volume accounting size of erythrocyte after scheming separation, by serum area, platelet rich plasma
Area, leukocyte area, erythrocyte are distinguished into volume area of different sizes, particularly leukocyte and account for the volume ratio of whole plasm and compare
It is little, leukocyte area is designed to grow not only but also thin cylinder-like structure.
3) compared with prior art, it is provided with pipe at the top of a kind of serum area of platelet rich plasma centrifuge tube of the invention
Lid, the lid is provided with injection orifice and passage, and the injection orifice is provided with injection port lid, and the passage is provided with ventilation
Port lid, the platelet rich plasma centrifuge tube for making the present invention is in closed state, it is not easy to be contaminated blood plasma.
4) compared with prior art, it is provided with air-permeable anti-bacterial in a kind of passage of platelet rich plasma centrifuge tube of the invention
Film, it is not easy to be contaminated blood plasma.
5) compared with prior art, a kind of bottom in the erythrocyte area of platelet rich plasma centrifuge tube of the invention is provided with rotation
Plug is turned a work, rotary-piston can be such that the liquid level of the blood plasma of separation layering uniformly rises or falls.
6) compared with prior art, a kind of side wall in the leukocyte area of platelet rich plasma centrifuge tube of the invention is provided with three
Lead to T-shaped controlled valve, facilitate the use of the T-shaped switch of threeway.
7) compared with prior art, a kind of injection orifice and drawing holes of platelet rich plasma centrifuge tube of the invention sets respectively
Put two different positions, it is not easy to be contaminated blood plasma.
8) a kind of compared with prior art, the T-shaped switch of threeway, the injection orifice of platelet rich plasma centrifuge tube of the invention
A kind of lid, the use of vent cap, the platelet rich plasma centrifuge tube for making the present invention is more sealed, it is to avoid deposited in operation
Caused sample contamination, further increases stability and the safety of platelet rich plasma making.
9) prior art is compared, and a kind of bottom in the serum area of platelet rich plasma centrifuge tube of the present invention includes falling
Truncated cone-shaped structure, the top in the erythrocyte area includes truncated cone-shaped structure, such two layers of gradient pipe diameter determing, rich platelet blood
Slurry centrifuge tube is integral type structure, further increases stability and the safety of platelet rich plasma making.
10) compared with prior art, the extracting method of a kind of platelet rich plasma of the invention, when liquid level is inclined on leukocyte
When high or low, can rotate rotary-piston makes liquid level on leukocyte down or up.
Description of the drawings
Fig. 1 is a kind of overall structure diagram of platelet rich plasma centrifuge tube of the embodiment of the present invention.
Fig. 2 is a kind of T-shaped switch of threeway, upper through hole, the lower through-hole of platelet rich plasma centrifuge tube of the embodiment of the present invention
With drawing holes structural representation.
Fig. 3 is a kind of flow chart of the extracting method of platelet rich plasma of the embodiment of the present invention.
Fig. 4 is a kind of another flow chart of the extracting method of platelet rich plasma of the embodiment of the present invention.
Description of reference numerals：
1st, serum area, 2, platelet rich plasma area, 3, leukocyte area, 4, erythrocyte area, 5, upper through hole, 6, lower through-hole, 7,
Drawing holes, 8, the T-shaped switch of threeway, 9, lid, 10, injection orifice, 11, passage, 12, injection port lid, 13, vent cap, 14, rotation
Turn a work plug, 15, the T-shaped controlled valve of threeway.
Specific embodiment
It is next with specific embodiment below in conjunction with the accompanying drawings that the invention will be further described.
With reference to shown in Fig. 1,2, a kind of platelet rich plasma centrifuge tube is embodiments provided, from top to bottom wrapped successively
Include serum area 1, platelet rich plasma area 2, leukocyte area 3, erythrocyte area 4；
Connected by upper through hole 5 between the platelet rich plasma area 2 and leukocyte area 3；
Connected by lower through-hole 6 between the leukocyte area 3 and erythrocyte area 4；
The side wall in the leukocyte area 3 is provided with drawing holes 7；
Correspond to the upper through hole 5, lower through-hole 6, drawing holes 7, the leukocyte area 3 is provided with the T-shaped switch 8 of threeway.
Wherein, the platelet rich plasma centrifuge tube is integral type structure, and the bottom in the serum area 1 includes reverse frustoconic
Structure, the platelet rich plasma area 2 be cylindrical structure, the leukocyte area 3 be cylindrical structure, the erythrocyte area 4
Top include truncated cone-shaped structure.
Wherein, the top in the serum area 1 is provided with lid 9.
Wherein, the lid 9 is provided with injection orifice 10 and passage 11.
Wherein, the injection orifice 10 is provided with injection port lid 12, and the passage 11 is provided with vent cap 13.
Wherein, the injection orifice 10 is arranged in the central area of the lid 9, the passage 11 and is provided with air-permeable anti-bacterial
Film (is not drawn into) in figure.
Wherein, the bottom in the erythrocyte area 4 is provided with rotary-piston 14.
Wherein, correspond to the T-shaped switch 8, the side wall in the leukocyte area 3 of the threeway and be provided with the T-shaped controlled valve 15 of threeway.
With reference to shown in Fig. 3, a kind of flow chart of the extracting method of platelet rich plasma is embodiments provided, including
Following steps：
Step S101, rotates the T-shaped controlled valve of threeway, makes through hole and lower through-hole conducting, drawing holes closing；
Step S102, opens injection port lid, vent cap；
Step S103, centrifuge tube is injected into by blood plasma from injection orifice, then closed injection port lid, vent cap；
Step S104, the centrifuge tube that will be equipped with blood plasma is put into centrifuge, preferably, centrifuge work
Make the time for 15 minutes, centrifuge operating rate is 400g；
Step S105, after blood plasma layering, opens vent cap；
If desired for leukocyte is extracted, the height for finding liquid level on leukocyte is higher than drawing holes；
Or leukocyte need not be such as extracted, the height for finding liquid level on leukocyte is less than drawing holes；
Then the height in leukocyte upper liquid face need not be adjusted, be directly entered next step.
Step S106, by the upper drawing holes of syringe connection, then rotates the T-shaped controlled valve of threeway, makes through hole and extraction
Hole turns on, lower through-hole closing, then opens vent cap, and using syringe platelet rich plasma is extracted.
With reference to shown in Fig. 4, a kind of another flow chart of the extracting method of platelet rich plasma is embodiments provided,
Comprise the following steps：
Step S201, rotates the T-shaped controlled valve of threeway, makes through hole and lower through-hole conducting, drawing holes closing；
Step S202, opens injection port lid, vent cap；
Step S203, centrifuge tube is injected into by blood plasma from injection orifice, then closed injection port lid, vent cap；
Step S204, the centrifuge tube that will be equipped with blood plasma is put into centrifuge, preferably, centrifuge work
Make the time for 15 minutes, centrifuge operating rate is 400g；
Step S205, after blood plasma layering, opens vent cap；
If desired for leukocyte is extracted, the height for finding liquid level on leukocyte is less than drawing holes；
Or leukocyte need not be such as extracted, the height for finding liquid level on leukocyte is higher than drawing holes；
Then the height in leukocyte upper liquid face is adjusted into next step.
Step S206, rotates rotary-piston and liquid level on leukocyte is adjusted to into leukocyte area；
If desired for leukocyte is extracted, then liquid level on leukocyte is raised to higher than drawing holes；
Leukocyte need not be such as extracted, then liquid level on leukocyte being pushed away as little as be less than drawing holes；
Step S207, by the upper drawing holes of syringe connection, then rotates the T-shaped controlled valve of threeway, makes through hole and extraction
Hole turns on, lower through-hole closing, then opens vent cap, and using syringe platelet rich plasma is extracted.
The above, is only present pre-ferred embodiments, and not the technical scope of the present invention is imposed any restrictions, therefore
Any trickle amendment, equivalent variations and modification that every technical spirit according to the present invention is made to above example, still belong to
In the range of technical solution of the present invention.
Claims (10)
1. a kind of platelet rich plasma centrifuge tube, it is characterised in that：From top to bottom include serum area, platelet rich plasma successively
Area, leukocyte area, erythrocyte area；
Connected by upper through hole between the platelet rich plasma area and leukocyte area；
Connected by lower through-hole between the leukocyte area and erythrocyte area；
The side wall in the leukocyte area is provided with drawing holes；
Correspond to the upper through hole, lower through-hole, drawing holes, the leukocyte area is provided with the T-shaped switch of threeway.
2. a kind of platelet rich plasma centrifuge tube according to claim 1, it is characterised in that：The platelet rich plasma from
Heart pipe is integral type structure, and the bottom in the serum area includes reverse frustoconic structure, and the platelet rich plasma area is cylinder
Structure, the leukocyte area is cylindrical structure, and the top in the erythrocyte area includes truncated cone-shaped structure.
3. a kind of platelet rich plasma centrifuge tube according to claim 1, it is characterised in that：Set at the top of the serum area
There is lid.
4. a kind of platelet rich plasma centrifuge tube according to claim 3, it is characterised in that：The lid is provided with injection
Hole and passage.
5. a kind of platelet rich plasma centrifuge tube according to claim 4, it is characterised in that：The injection orifice is provided with note
Perforation lid, the passage is provided with vent cap.
6. a kind of platelet rich plasma centrifuge tube according to claim 4, it is characterised in that：The injection orifice is arranged on institute
The central area of lid is stated, air-permeable anti-bacterial film is provided with the passage.
7. a kind of platelet rich plasma centrifuge tube according to claim 1, it is characterised in that：The bottom in the erythrocyte area
It is provided with rotary-piston.
8. a kind of platelet rich plasma centrifuge tube according to claim 1, it is characterised in that：Correspond to the threeway T-shaped
Switch, the side wall in the leukocyte area are provided with the T-shaped controlled valve of threeway.
9. a kind of extracting method of platelet rich plasma, it is characterised in that comprise the following steps：
The T-shaped controlled valve of threeway is rotated, through hole and lower through-hole conducting, drawing holes closing is made；
Open injection port lid, vent cap；
Blood plasma is injected into into centrifuge tube from injection orifice, then closed injection port lid, vent cap；
The centrifuge tube that will be equipped with blood plasma is put into centrifuge；
After blood plasma layering, vent cap is opened；
By the upper drawing holes of syringe connection, the T-shaped controlled valve of threeway is then rotated, make through hole and drawing holes conducting, lower through-hole
Closing, then vent cap is opened, extract platelet rich plasma using syringe.
10. the extracting method of a kind of platelet rich plasma according to claim 9, it is characterised in that described to treat blood plasma point
After layer, after opening vent cap, comprise the following steps：
Rotate rotary-piston and liquid level on leukocyte is adjusted to into leukocyte area；
If desired for leukocyte is extracted, then liquid level on leukocyte is raised to higher than drawing holes；
Leukocyte need not be such as extracted, then liquid level on leukocyte being pushed away as little as be less than drawing holes.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710076874.9A CN106669875B (en) | 2017-02-13 | 2017-02-13 | Platelet-rich plasma centrifuge tube and extraction method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710076874.9A CN106669875B (en) | 2017-02-13 | 2017-02-13 | Platelet-rich plasma centrifuge tube and extraction method thereof |
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| CN106669875B CN106669875B (en) | 2022-07-01 |
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| CN112120712A (en) * | 2020-09-24 | 2020-12-25 | 北京大学第三医院（北京大学第三临床医学院） | Leukocyte-poor platelet-rich plasma (PRP) preparation set |
| CN113440927A (en) * | 2020-03-27 | 2021-09-28 | 张文杰 | Device and method for extracting water-soluble components of emulsified and broom-corn-like fat |
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