CN106632008A - 一种氯羟吡啶生产工艺 - Google Patents
一种氯羟吡啶生产工艺 Download PDFInfo
- Publication number
- CN106632008A CN106632008A CN201510879926.7A CN201510879926A CN106632008A CN 106632008 A CN106632008 A CN 106632008A CN 201510879926 A CN201510879926 A CN 201510879926A CN 106632008 A CN106632008 A CN 106632008A
- Authority
- CN
- China
- Prior art keywords
- clopidol
- production process
- product
- dissolving
- serving
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- ZDPIZLCVJAAHHR-UHFFFAOYSA-N Clopidol Chemical compound CC1=NC(C)=C(Cl)C(O)=C1Cl ZDPIZLCVJAAHHR-UHFFFAOYSA-N 0.000 title claims abstract description 11
- 229960000731 clopidol Drugs 0.000 title claims abstract description 11
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 6
- 238000005516 engineering process Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract description 9
- 239000013078 crystal Substances 0.000 abstract description 4
- 238000001035 drying Methods 0.000 abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 3
- 238000001914 filtration Methods 0.000 abstract description 2
- 238000007873 sieving Methods 0.000 abstract description 2
- 238000001816 cooling Methods 0.000 abstract 2
- 238000002156 mixing Methods 0.000 abstract 2
- 239000013064 chemical raw material Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 238000004064 recycling Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 description 5
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 241000223924 Eimeria Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 230000001165 anti-coccidial effect Effects 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
氯羟吡啶是一种重要的化工原料，氯羟吡啶的生产工艺为：在溶解釜内加入氯羟吡啶原料药粗品，用计量泵加入甲醇，同时升温至40℃左右，氯羟吡啶原料药混合溶解约5h，待完全溶解后用夹套冷冻水降温，降至5℃左右，产品结晶析出，完成后放入过滤器进行离心过滤，得到晶体去烘干。母液送至精馏塔回收套用。烘干后的晶体经过粉碎、过筛、混合后，包装得到成品。
Description
分子式：C7H7NOCl2
分子量：192.04
结构式
产品性状：本品为白色或类白色粉末，无臭。本品在甲醇或乙醇中微溶，在水、丙酮、乙醚、苯中不溶；在氢氧化钠中溶解。
主要用途：氯羟吡啶是我国使用最广泛的抗球虫药，其抗虫谱较广，对鸡的柔嫩、
毒害、布氏、巨型、堆型、和缓和早熟艾美耳球虫均有良效。
3、工艺说明
在溶解釜内加入氯羟吡啶原料药粗品，用计量泵加入甲醇，同时升温至40℃左右，氯羟吡啶原料药混合溶解约5h，待完全溶解后用夹套冷冻水降温，降至5℃左右，产品结晶析出，完成后放入过滤器进行离心过滤，得到晶体去烘干。母液送至精馏塔回收套用。烘干后的晶体经过粉碎、过筛、混合后，包装得到成品。
附图说明：
图1是物料平衡图。
Claims (2)
1.一种氯羟吡啶生产工艺。
2.本发明涉及生产原料成分及配比。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510879926.7A CN106632008A (zh) | 2015-12-06 | 2015-12-06 | 一种氯羟吡啶生产工艺 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510879926.7A CN106632008A (zh) | 2015-12-06 | 2015-12-06 | 一种氯羟吡啶生产工艺 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106632008A true CN106632008A (zh) | 2017-05-10 |
Family
ID=58851205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510879926.7A Pending CN106632008A (zh) | 2015-12-06 | 2015-12-06 | 一种氯羟吡啶生产工艺 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106632008A (zh) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3246001A (en) * | 1963-09-25 | 1966-04-12 | Dow Chemical Co | 3, 5-dichloro-2, 6-dimethyl-4-pyridinol |
| CN1044462A (zh) * | 1989-01-26 | 1990-08-08 | 程丽波 | 常压法制备3，5-二氯-2，6-二甲基吡啶酚 |
-
2015
- 2015-12-06 CN CN201510879926.7A patent/CN106632008A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3246001A (en) * | 1963-09-25 | 1966-04-12 | Dow Chemical Co | 3, 5-dichloro-2, 6-dimethyl-4-pyridinol |
| CN1044462A (zh) * | 1989-01-26 | 1990-08-08 | 程丽波 | 常压法制备3，5-二氯-2，6-二甲基吡啶酚 |
Non-Patent Citations (1)
| Title |
|---|
| 龚锐，等: "氯吡醇合成方法的研究", 《化学世界》 * |
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| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170510 |