CN106581299B - Traditional Chinese medicine composition for improving kidney qi deficiency of middle-aged and old people and application thereof - Google Patents
Traditional Chinese medicine composition for improving kidney qi deficiency of middle-aged and old people and application thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for improving kidney qi deficiency of middle-aged and old people and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 15-25 parts of codonopsis pilosula, 15-25 parts of radix astragali preparata, 12-18 parts of angelica, 15-25 parts of fructus psoraleae, 15-25 parts of pyrola, 10-20 parts of wolfberry fruit and 10-20 parts of red paeony root. Clinical tests show that the traditional Chinese medicine composition can obviously improve the symptoms and the life quality of middle-aged and elderly patients with kidney qi deficiency, so that the traditional Chinese medicine composition can be used for preparing medicines for treating the kidney qi deficiency and delaying senility, and has the advantages of few medicinal components, convenience in preparation and low cost.
Description
Technical Field
The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for improving kidney qi deficiency of middle-aged and old people and application thereof.
Background
At present, with the development of society, people gradually enter an aging society, and more attention is paid to how to delay the aging process and improve the life quality of middle-aged and elderly people. The traditional Chinese medicine has long-term understanding on human aging or premature senility and is extremely rich in content and recognized by most scholars. The best one is the one with kidney deficiency and aging. Kidneys store essence, which is the source of innate foundation and life, and kidneys are the main part to host and maintain all physiological functions of human body, so that the kidneys balance uniformly and can self-regulate and stabilize normal activities, thereby resisting diseases. The deficiency of kidney qi leads to the biochemical failure of qi, blood and body fluids of the five viscera, and various aging diseases are increasingly manifested. The TCM also believes that the chronic disease and the chronic disease do not damage kidney qi, so it is said that the disease is a long-lasting disease, and the disease is a poor disease and kidney. The kidney qi impairment is usually manifested as soreness and weakness of the waist and knees, lassitude and hypodynamia.
At present, more traditional Chinese medicine formulas aiming at kidney qi deficiency are used in traditional Chinese medicine treatment. For example, chinese patent document CN200510075262.5, published japanese 2006.12.13, discloses a pharmaceutical composition for treating kidney qi deficiency syndrome and a quality control method thereof, wherein the pharmaceutical composition is prepared from the following raw material medicines: 20-40 parts of fructus cnidii, 20-40 parts of ligusticum wallichii, 50-80 parts of semen cuscutae, 20-40 parts of fructus psoraleae, 20-40 parts of poria cocos, 15-25 parts of red ginseng, 10-20 parts of fennel, 30-40 parts of schisandra chinensis, 60-120 parts of cherokee rose fruit, 10-20 parts of bighead atractylodes rhizome, 40-60 parts of angelica sinensis, 25-40 parts of raspberry, 60-90 parts of prepared polygonum multiflorum, 10-20 parts of semen plantaginis, 60-120 parts of prepared rehmannia root, 50-80 parts of wolfberry fruit, 40-60 parts of Chinese yam, 60-120 parts of epimedium, 60-120 parts of fenugreek, 40-60 parts of astragalus mongholicus, 40-60 parts of cistanche and 10-20 parts of honey-fried licorice root, the pharmaceutical composition and the granular preparation thereof have the functions of regulating yin and yang, warming yang, tonifying kidney, calming nerves, securing essence, and strengthening body resistance, and are clinically used for treating impotence, spermatorrhea, soreness and pain in waist and lower extremities, lassitude, frequent nocturia, intolerance of cold, menorrhagia, and clear and thin leucorrhea. For example, the qi-deer kidney-invigorating granule disclosed in the paper "qi-deer kidney-invigorating granule improves the clinical observation of the middle-aged and elderly people's kidney qi deficiency syndrome" published by the applicant in the paper "39 th of 2012, the journal of traditional Chinese medicine of Liaoning" in the journal of China, wherein the formula is ginseng and astragalus, and the technique is used for replenishing qi to invigorate the spleen; gui and Shao tonify blood and nourish heart and liver; radix Dipsaci, fructus Psoraleae, herba Pyrolae, and fructus Lycii, and has effects in invigorating tendons and bones. The prescription is a homemade preparation in the hospital of the patent applicant, originated in the 80 th century, is prepared by summarizing the crystallization of multiple famous old Chinese medicinal wisdom, and has good curative effect clinically.
However, the theory of traditional Chinese medicine is profound, the compatibility of Chinese medicinal herbs is numerous, and the compatibility of the Chinese medicinal herbs is more delicate, so that the Chinese medical scholars can have unique experience and improvement on the formulas. The inventor of the application further improves the original medlar deer kidney invigorating granules based on the deep theoretical basis of the traditional Chinese medicine and the knowledge of the prescription compatibility so as to improve the treatment effect of the prescription.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for improving the kidney qi deficiency of middle-aged and old people aiming at the defects in the prior art.
The invention also aims to provide the application of the traditional Chinese medicine composition.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition granules.
In order to achieve the first purpose, the invention adopts the technical scheme that:
a traditional Chinese medicine composition for improving kidney qi deficiency of middle-aged and elderly people is prepared from the following raw material medicines in parts by weight: 15-25 parts of codonopsis pilosula, 15-25 parts of radix astragali preparata, 12-18 parts of angelica, 15-25 parts of fructus psoraleae, 15-25 parts of pyrola, 10-20 parts of wolfberry fruit and 10-20 parts of red paeony root.
Preferably, the traditional Chinese medicine is prepared from the following raw material medicines in parts by weight: 18-22 parts of codonopsis pilosula, 18-22 parts of radix astragali preparata, 15-18 parts of angelica, 18-22 parts of fructus psoraleae, 18-22 parts of pyrola, 14-18 parts of wolfberry fruit and 14-18 parts of red paeony root.
More preferably, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 20 parts of codonopsis pilosula, 20 parts of radix astragali preparata, 16.67 parts of angelica, 20 parts of fructus psoraleae, 20 parts of herba pyrolae, 15 parts of wolfberry fruit and 15 parts of red paeony root.
As a specific embodiment of the invention, the dosage form of the traditional Chinese medicine composition is granules, capsules, tablets or mixture.
In order to achieve the second object, the invention adopts the technical scheme that:
the application of the traditional Chinese medicine composition in preparing the medicine for improving the kidney qi deficiency of the middle-aged and the elderly people.
The application of the traditional Chinese medicine composition in preparing anti-aging medicines.
In order to achieve the third object, the invention adopts the technical scheme that:
the preparation method of the granules of the traditional Chinese medicine composition comprises the following steps: weighing the raw materials, adding 6-10 times and 2-6 times of water respectively, decocting twice, keeping the temperature at 80-90 ℃ for 10-30 minutes after each boiling, filtering the decoction, combining the filtrates, concentrating to a relative density of more than 1.0, standing for more than 10 hours, taking the supernatant, adding a conventional medicinal carrier, mixing uniformly, drying, crushing into fine powder, adding a proper amount of ethanol, granulating, and drying to obtain the traditional Chinese medicine composition.
Herein, the radix astragali preparata is a processed product of radix astragali, and the preparation method comprises the following steps: parching radix astragali slice with honey until it is not sticky; the herba Pyrolae is dry whole plant of Pyrolae Callliantha H.Andres of Pyrolaceae.
The invention has the advantages that:
1. the Chinese medicinal composition selects the medlar and the pyrola as the monarch medicaments, has sweet taste and mild nature, enters liver and kidney meridians, and has the function of tonifying kidney yin; the herba Pyrolae is slightly sweet and warm in nature, and enters liver, kidney and lung meridians, and has effects of invigorating kidney, tonifying yang, and strengthening tendons and bones; the two are monarch drugs, which can tonify liver and kidney, nourish yin and warm yang, and play the role of yin and yang. The fructus psoraleae is selected as a ministerial drug, is pungent and bitter, has warm property, and has the effects of invigorating the kidney, tonifying yang, strengthening waist, benefiting vital gate fire and tonifying yang of the deer-horn-containing herbs. The formula is supplemented with radix codonopsitis, radix astragali and angelica, the radix codonopsitis is sweet and neutral in taste and has the effects of invigorating spleen-stomach, replenishing qi, harmonizing stomach and promoting the production of body fluid; the astragalus root is sweet in taste and slightly warm in nature, enters spleen and lung meridians, and has the effects of tonifying qi and invigorating yang, and reinforcing the defensive qi and consolidating the exterior; the angelica is sweet, pungent and warm in flavor, enters liver, heart and spleen channels, and has the effects of enriching blood and promoting blood circulation; the three medicines can also tonify qi, promote the production of body fluid, nourish blood, activate blood, tonify without stagnation and regulate qi and blood together after assisting the monarch and ministerial medicines, so that the qi and blood are generated and activated, and blood stasis cannot be remained. In the recipe, radix Paeoniae Rubra, with bitter taste and slightly cold nature, enters liver and spleen meridians to remove its actions of activating blood and dissipating blood stasis, and yang tonics in formula with slightly cold nature are added to avoid sudden hyperactivity. Although the recipe is good at invigorating kidney, it is really an agent for tonifying qi, blood, yin and yang of the five zang organs because kidney is the root of yin and yang of the five zang organs and is the key point of tonifying. Clinical experiments show that compared with the original medlar deer kidney-invigorating prescription, the traditional Chinese medicine composition has more remarkable improvement on symptoms and life quality of middle-aged and elderly patients with kidney qi deficiency, has more precise and appropriate compatibility, and has great potential in treating clinically relevant diseases.
2. The traditional Chinese medicine composition has few medicinal ingredients, is more convenient to prepare and has low cost.
Detailed Description
The following provides a detailed description of specific embodiments of the present invention.
EXAMPLE 1 preparation of a combination of Chinese medicinal compositions of the present invention
15 parts of codonopsis pilosula, 25 parts of radix astragali preparata, 12 parts of angelica, 25 parts of fructus psoraleae, 15 parts of pyrola, 20 parts of wolfberry fruit and 10 parts of red paeony root by a conventional method.
Example 2 preparation of a combination of Chinese medicinal compositions of the present invention
25 parts of codonopsis pilosula, 15 parts of radix astragali preparata, 18 parts of angelica, 15 parts of fructus psoraleae, 25 parts of pyrola, 10 parts of wolfberry fruit and 20 parts of red paeony root by a conventional method.
Example 3 preparation of a mixture of the Chinese medicinal composition of the present invention
15 parts of codonopsis pilosula, 15 parts of radix astragali preparata, 18 parts of angelica, 25 parts of fructus psoraleae, 15 parts of pyrola, 10 parts of wolfberry fruit and 20 parts of red paeony root by a conventional method.
Example 4 preparation of a mixture of Chinese medicinal compositions of the present Invention (IV)
25 parts of codonopsis pilosula, 25 parts of radix astragali preparata, 12 parts of angelica, 15 parts of fructus psoraleae, 25 parts of pyrola, 20 parts of wolfberry fruit and 10 parts of red paeony root by a conventional method.
Example 5 preparation of a mixture of Chinese medicinal compositions of the present invention (V)
15 parts of codonopsis pilosula, 15 parts of radix astragali preparata, 12 parts of angelica, 15 parts of fructus psoraleae, 25 parts of pyrola, 20 parts of wolfberry fruit and 20 parts of red paeony root by a conventional method.
Example 6 preparation of a mixture of the Chinese medicinal composition of the present invention (VI)
25 parts of codonopsis pilosula, 25 parts of radix astragali preparata, 18 parts of angelica, 15 parts of fructus psoraleae, 15 parts of pyrola, 10 parts of wolfberry fruit and 10 parts of red paeony root by a conventional method.
EXAMPLE 7 preparation of the combination of Chinese medicinal compositions of the present invention (VII)
18 parts of codonopsis pilosula, 22 parts of radix astragali preparata, 15 parts of angelica, 22 parts of fructus psoraleae, 18 parts of pyrola, 18 parts of medlar and 14 parts of red paeony root by a conventional method.
EXAMPLE 8 preparation of a combination of Chinese medicinal compositions of the present invention (eight)
22 parts of codonopsis pilosula, 18 parts of radix astragali preparata, 18 parts of angelica, 18 parts of fructus psoraleae, 22 parts of pyrola, 14 parts of wolfberry fruit and 18 parts of red paeony root by a conventional method.
Example 9 preparation of a mixture of the Chinese medicinal composition of the present invention (nine)
18 parts of radix codonopsitis, 18 parts of radix astragali preparata, 18 parts of angelica, 22 parts of fructus psoraleae, 18 parts of pyrola, 14 parts of medlar and 18 parts of red paeony root by a conventional method.
EXAMPLE 10 preparation of a combination of Chinese medicinal compositions of the present invention (Ten)
22 parts of codonopsis pilosula, 22 parts of radix astragali preparata, 18 parts of angelica, 18 parts of fructus psoraleae, 18 parts of pyrola, 14 parts of wolfberry fruit and 18 parts of red paeony root by a conventional method.
EXAMPLE 11 preparation of a combination of Chinese medicinal compositions of the present invention (eleven)
20 parts of codonopsis pilosula, 20 parts of radix astragali preparata, 16.67 parts of angelica, 20 parts of fructus psoraleae, 20 parts of herba pyrolae, 15 parts of wolfberry fruit and 15 parts of red paeony root by a conventional method.
EXAMPLE 12 preparation of granules of the Chinese medicinal composition of the present invention
Weighing the raw materials according to the weight part ratio of any one of embodiments 1-11, adding 8 times and 4 times of water respectively, decocting twice, keeping the temperature at 85 ℃ for 20 minutes after each boiling, filtering the decoction, combining the filtrates, concentrating to a relative density of more than 1.0, standing for more than 10 hours, taking the supernatant, adding a proper amount of dextrin and steviosin, mixing uniformly, drying, crushing into fine powder, adding a proper amount of ethanol, granulating, and drying to obtain the traditional Chinese medicine composition.
EXAMPLE 13 preparation of capsules of the Chinese medicinal composition of the present invention
Weighing the raw materials according to the weight part ratio of any one of embodiments 1-11, adding 8 times and 4 times of water respectively, decocting twice, keeping the temperature at 85 ℃ for 20 minutes after each boiling, filtering the decoction, combining the filtrates, concentrating to a relative density of more than 1.0, standing for more than 10 hours, taking the supernatant, adding a proper amount of dextrin and steviosin, mixing uniformly, drying, crushing into fine powder, adding a proper amount of ethanol, granulating, drying, crushing, filling and encapsulating.
EXAMPLE 14 preparation of tablets of the Chinese medicinal composition of the present invention
Weighing the raw materials according to the weight part ratio of any one of embodiments 1-11, adding 8 times and 4 times of water respectively, decocting twice, keeping the temperature at 85 ℃ for 20 minutes after each boiling, filtering the decoction, combining the filtrates, concentrating to a relative density of more than 1.0, standing for more than 10 hours, taking the supernatant, adding a proper amount of dextrin and steviosin, mixing uniformly, drying, crushing into fine powder, adding a proper amount of ethanol, granulating, drying, crushing, and pressing into tablets.
Example 15 clinical trial
1 data and method
1.1 general data
160 cases of patients who have been diagnosed in the elderly outpatient service and inpatient ward of the Yueyang combined hospital affiliated to the Shanghai medical university from 1 month to 2014 8 months in 2013 are collected and divided into two groups according to a random table method. Treatment groups 80, 57 men and 23 women; age 46-88 years, mean (65.88 + -6.27) years; the body weight was averaged (62.90. + -. 10.05) kg. 80 cases of the control group, 52 cases of men and 28 cases of women; the age is 47-90 years, and the average (64.08 +/-8.73) year; the average body weight was (61.41. + -. 7.99) kg. The age, weight, sex and the like of the two groups have no significant difference (P is more than 0.05) and are comparable. Follow the principle of voluntary and informed consent.
1.2 case selection
1.2.1 inclusion criteria
Refer to the standard for diagnosis and treatment of Chinese medicinal diseases issued by the national administration of traditional Chinese medicine in 1994. (1) The age is > 45 years; (2) meets the diagnosis standard of kidney qi deficiency syndrome: 2 main symptoms of kidney qi deficiency syndrome; or 1 item of main symptoms plus 2 items of secondary symptoms.
The traditional Chinese medicine syndrome diagnosis standard is as follows: the main symptoms are: soreness of the lumbar spine, fatigue, lassitude, edema, anorexia, or abdominal distension; the secondary symptoms are as follows: loose stool, frequent or nocturnal urination, pale red tongue with teeth marks, thin and white coating, and thready pulse.
1.2.2 exclusion criteria
(1) Those that do not meet inclusion criteria; (2) cases not within the scope of action; (3) patients with obvious accompanied syndrome inclusion or combination; (4) other medicines with the functions of replenishing qi and blood, nourishing liver and kidney, strengthening tendons and bones, and soothing and warming and nourishing are taken in nearly 1 month; (5) patients participated in other clinical trials within 3 months; (6) a woman in lactating or preparing pregnancy; (7) allergic constitution and people allergic to various drugs; (8) suspected or confirmed history of drug abuse, or, at the discretion of the investigator, other pathologies or conditions that reduce or complicate enrollment, such as conditions susceptible to missed visits with frequently changing working environments; (9) patients with serious primary diseases such as liver, kidney, hemopoietic system, endocrine system, etc. and psychosis; (10) the patients with critical illness (such as serious cardiac insufficiency, serious infection, tumor, etc.) have difficulty in making a definite evaluation on the effectiveness and safety of the medicine.
1.3 methods of treatment
The Chinese medicinal composition granules are administered to a treatment group, and the preparation method comprises the following steps: weighing 200g of codonopsis pilosula, 200g of radix astragali preparata, 166.7g of angelica, 200g of fructus psoraleae, 200g of pyrola, 150g of wolfberry and 150g of radix paeoniae rubra, respectively adding 8 times and 4 times of water for decoction twice, keeping the temperature at 85 ℃ for 20 minutes after each time of boiling, filtering decoction, combining filtrates, concentrating until the relative density is 1.5, standing for 12 hours, taking supernatant, adding a proper amount of dextrin and 4.2g of steviosin, mixing uniformly, drying, crushing into fine powder, adding a proper amount of ethanol for granulation, drying, preparing into 1000g, and packaging 12g in each bag.
The kidney-invigorating granules of the wolfberry and the deer are given to a control group, and the preparation method comprises the following steps: weighing 200g of codonopsis pilosula, 200g of radix astragali preparata, 166.7g of angelica sinensis, 200g of teasel root, 200g of fructus psoraleae, 200g of pyrola, 150g of wolfberry fruit, 150g of rhizoma atractylodis macrocephalae and 150g of radix paeoniae alba, respectively adding 8 times and 4 times of water for decocting twice, keeping the temperature at 85 ℃ for 20 minutes after each boiling, filtering decoction, combining filtrates, concentrating until the relative density is 1.5, standing for 12 hours, taking supernatant, adding a proper amount of dextrin and 4.2g of steviosin, uniformly mixing, drying, crushing into fine powder, adding a proper amount of ethanol for granulating, drying, preparing into 1000g, and packaging 12g in each bag.
The above medicines are all taken with boiling water, 12g each time, 2 times daily. During which the dose cannot be changed. The first day after qualified enrollment was taken as day 1 of study medication. The treatment was continued for 6 weeks.
1.4 Observation items
(1) The safety index is as follows: heart rate, respiration, blood pressure, and other general items; routine examination of blood, urine and feces; liver and kidney functions; an electrocardiogram. (2) Evaluation of efficacy: symptom scoring: the main symptoms comprise soreness and pain of waist and back, psychroalgia of waist and back, tiredness, debilitation, edema, deficiency of qi, no speaking desire, aversion to cold, dizziness, tinnitus, etc. 0 point is recorded for no symptom or disappearance; mild symptoms or sometimes 1 point; moderate symptoms, and in mild cases, the patients are recorded for 2 points; the symptoms were scored significantly for 3 points.
Quality of life score (refer to "the clinical observation of qi deficiency syndrome of middle-aged and elderly people improved by qi-tonifying and kidney-invigorating granule of wolfberry and deer published in 2012, vol.39, No. 7 of Liaoning TCM journal): mainly comprises appetite, sleep, general activities, mental states, emotions, interaction with people, life interests and the like. And scoring according to 0 point of good score and 10 points of extreme difference, and selecting in the range of 0-10 respectively.
Evaluation criteria: case score is the sum of the scores of each symptom. The clinical cure is as follows: the clinical symptoms and physical signs of the traditional Chinese medicine disappear or basically disappear, and the syndrome integral is reduced by more than or equal to 95 percent. The effect is shown: the clinical symptoms and physical signs of the traditional Chinese medicine are obviously improved, and the syndrome integral is reduced by more than or equal to 70 percent. The method has the following advantages: the clinical symptoms and physical signs of the traditional Chinese medicine are improved, and the syndrome integral is reduced by more than or equal to 30 percent. And (4) invalidation: the clinical symptoms and physical signs of the traditional Chinese medicine are not obviously improved or even aggravated, and the syndrome integral is reduced by less than 30 percent.
Note that the calculation formula (nimodipine method) ═ total score before treatment-total score after treatment)/total score before treatment × 100% was calculated.
1.5 statistical treatment
Data were analyzed using SPSS18.0 software and data
Representing, t-test and variance analysis for metrology data, and χ for count data2The test was statistically processed.
2 results and analysis
The total number of the patients fell off 5 cases after the test, the falling off rate was 3.13%, wherein the treatment group fell off 1 case; the control group had 4 cases missing. The trial finally included 155 cases, 79 cases in the treatment group, and 76 cases in the control group.
2.1 comparison of therapeutic effects of two groups of symptoms
The symptoms of aching and aching waist and back, cold and painful waist and back, tiredness and hypodynamia, edema, qi deficiency and no speaking desire, aversion to cold, cold limbs, dizziness, tinnitus and the like of the two groups of patients after treatment are all obviously improved, and the statistical result of the total effective rate is shown in table 1. Compared with the total effective rate of the control group, the difference of the treatment group and the control group has statistical significance (P is less than 0.01).
TABLE 1 comparison of the two groups of symptoms
| Group of | Example number (example) | Clinical recovery (case) | Obvious effect (example) | Effective (example) | Invalid (example) | Total effective rate |
| Treatment group | 79 | 18 | 33 | 22 | 6 | 92.41％＊＊ |
| Control group | 76 | 6 | 17 | 34 | 19 | 75.00％ |
Note that ＊＊ P was < 0.01 compared to the control group.
2.2 two-group quality of Life comparison
After treatment, the appetite, sleep, general activities, mental state, mood, interaction with people and life interest of the two groups of patients are all obviously improved, and the statistical result of the improvement rate of the life quality is shown in a table 2. Compared with the improvement rate of the life quality of the control group, the treatment group has statistical significance (P is less than 0.01) on the differences of appetite, mental state and emotion, has statistical significance (P is less than 0.05) on the differences of sleep, general activities and life interests, has no statistical significance (P is more than 0.05) on the aspect of human interaction, and is possibly related to the influence of various factors such as personal characters, living environment and the like on the condition of human interaction besides the influence of physical health conditions.
Table 2 comparison of the improvement rates of quality of life
| Item/group classification | Treatment group | Control group |
| Appetite stimulation | 0.84±0.33 | 0.55±0.20＊＊ |
| Sleep mode | 0.76±0.32 | 0.58±0.31＊ |
| General activities | 0.72±0.40 | 0.57±0.29＊ |
| Mental state | 0.85±0.36 | 0.64±0.30＊＊ |
| Mood(s) | 0.77±0.42 | 0.52±0.27＊＊ |
| Interact with people | 0.69±0.39 | 0.59±0.34 |
| Interest in life | 0.71±0.28 | 0.56±0.24＊ |
Note that ＊ P was < 0.05 and ＊＊ P was < 0.01, compared to the control.
The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and additions can be made without departing from the method of the present invention, and these modifications and additions should also be regarded as the protection scope of the present invention.
Claims (7)
1. A traditional Chinese medicine composition for improving kidney qi deficiency of middle-aged and elderly people is characterized by being prepared from the following raw material medicines in parts by weight: 15-25 parts of codonopsis pilosula, 15-25 parts of radix astragali preparata, 12-18 parts of angelica, 15-25 parts of fructus psoraleae, 15-25 parts of pyrola, 10-20 parts of wolfberry fruit and 10-20 parts of red paeony root; the preparation method of the traditional Chinese medicine composition comprises the following steps: weighing the raw materials, adding 6-10 times and 2-6 times of water respectively, decocting twice, keeping the temperature at 80-90 ℃ for 10-30 minutes after each boiling, filtering the decoction, combining the filtrates, concentrating to a relative density of more than 1.0, standing for more than 10 hours, taking the supernatant, adding a conventional medicinal carrier, mixing uniformly, drying, crushing into fine powder, adding a proper amount of ethanol, granulating, and drying to obtain the traditional Chinese medicine composition.
2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw material medicines in parts by weight: 18-22 parts of codonopsis pilosula, 18-22 parts of radix astragali preparata, 15-18 parts of angelica, 18-22 parts of fructus psoraleae, 18-22 parts of pyrola, 14-18 parts of wolfberry fruit and 14-18 parts of red paeony root.
3. The traditional Chinese medicine composition according to claim 2, which is prepared from the following raw material medicines in parts by weight: 20 parts of codonopsis pilosula, 20 parts of radix astragali preparata, 16.67 parts of angelica, 20 parts of fructus psoraleae, 20 parts of herba pyrolae, 15 parts of wolfberry fruit and 15 parts of red paeony root.
4. The Chinese medicinal composition according to any one of claims 1 to 3, wherein the Chinese medicinal composition is in the form of granules, capsules or tablets.
5. The use of the Chinese medicinal composition of any one of claims 1-3 in the preparation of a medicament for improving kidney qi deficiency in the middle-aged and elderly.
6. Use of the Chinese medicinal composition of any one of claims 1-3 in the preparation of an anti-aging medicament.
7. A method for preparing granules of the Chinese medicinal composition according to any one of claims 1 to 3, which comprises the following steps: weighing the raw materials, adding 6-10 times and 2-6 times of water respectively, decocting twice, keeping the temperature at 80-90 ℃ for 10-30 minutes after each boiling, filtering the decoction, combining the filtrates, concentrating to a relative density of more than 1.0, standing for more than 10 hours, taking the supernatant, adding a conventional medicinal carrier, mixing uniformly, drying, crushing into fine powder, adding a proper amount of ethanol, granulating, and drying to obtain the traditional Chinese medicine composition.
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