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CN106588870A - Substituted salicylamide compound and application thereof - Google Patents

Substituted salicylamide compound and application thereof Download PDF

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Publication number
CN106588870A
CN106588870A CN201510679611.8A CN201510679611A CN106588870A CN 106588870 A CN106588870 A CN 106588870A CN 201510679611 A CN201510679611 A CN 201510679611A CN 106588870 A CN106588870 A CN 106588870A
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alkyl
halo
carbonyl
substituted
alkoxyl
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CN106588870B (en
Inventor
张来俊
葛家成
葛尧伦
刘羽
王心怡
白复芹
司国栋
刘晓晨
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Hailir Pesticides and Chemicals Group Co Ltd
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Hailir Pesticides and Chemicals Group Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/60—1,4-Diazines; Hydrogenated 1,4-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
    • A01N47/06—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom containing —O—CO—O— groups; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/18—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/20—N-Aryl derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/36—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< directly attached to at least one heterocyclic ring; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention discloses a substituted salicylamide compound and a N-oxide, a salt and a composition thereof. The structure of the compound is shown by a general formula I, and the definitions of various substituting groups in the formula are shown in the description. The substituted salicylamide compound disclosed by the invention has broad-spectrum insecticidal activity, very good activity to aphids, and better activity to especially diamond-back moths and beet armyworms, and can obtain a very good control effect with a relatively low dose.

Description

Substituted salicylamide class compound and its application
Technical field
The invention belongs to parasite killing field, more particularly to a kind of substituted salicylamide class compound and N- oxides, salt and Compositionss, and using their applications in agricultural or other field as insecticide.
Background technology
O-formammidotiazol-benzamide compounds (ryanodine receptor class) are the preventing and treating lepidoptera pests developed in recent years Effective insecticide.
The following compound with insecticidal activity is disclosed in patent WO2007093402：
The following compound with insecticidal activity is disclosed in patent WO2009010260：
Above patent (application) though in all disclosed compounds have similarity with the compounds of this invention, structure is still deposited Significant different.
The content of the invention
It is an object of the invention to provide a kind of replacement bigcatkin willow that various pest and disease damages can be just controlled under the dosage of very little Amides compound and its N- oxides or its salt, it can be applicable to the controlling invertebrate evil in agronomy and non-agronomic environments Worm.
Technical scheme is as follows：
The present invention provides a kind of substituted salicylamide class compound, as shown in formula I：
In formula：
A, B may be the same or different, and be respectively and independently selected from O, S or NRa；Ra=H, CN, NO2、NH2、NHCH3、C1-C6Alkyl, Halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C2-C6Thiazolinyl, Halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl；
X is selected from H, halogen, CN, NO2、NH2, CHO, CH=NOCH3, CH=NNHCH3, CH=NN (CH3)2、C1-C6Alkyl, Halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C2-C6Thiazolinyl, Halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl；
Y is selected from O, S, S (=O), S (=NRb), S (=O)n(=NRb)2-n(n=1 or 2；Rb=H, CN, NO2) or NRc；Rc =H, CN, NO2、NH2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxyl, halogen For C1-C6Alkoxyl, C1-C6Alkylamino radical, halo C1-C6Alkylamino radical, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1- C6Alkylaminocarbonyl, halo C1-C6Alkylaminocarbonyl, C1-C6Alkylamino radical thiocarbonyl, halo C1-C6Alkylamino radical thiocarbonyl, C1- C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6 Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkylaminocarbonyl C1-C6Alkyl, halo C1-C6Alkylaminocarbonyl C1-C6Alkyl, replacement or Unsubstituted aryl carbonyl, substituted or unsubstituted aryloxycarbonyl, substituted or unsubstituted Heteroarylcarbonyl, replacement do not take The Heteroaryloxycarbonyl in generation, substituted or unsubstituted aryl amine carbonyl, substituted or unsubstituted aryl amine thiocarbonyl, C1-C6Alkane Sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alcoxyl sulfinyl, halo C1-C6Alcoxyl sulfinyl, C1-C6Alkane sulphonyl Base, halo C1-C6Alkane sulfonyl, C1-C6Alcoxyl sulfonyl, halo C1-C6Alcoxyl sulfonyl；
Z is selected from N or CRd；Rd=H, halogen or NO2；
R1Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halogen For C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alcoxyl Sulfinyl, halo C1-C6Alcoxyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alcoxyl sulfonyl, Halo C1-C6Alcoxyl sulfonyl, amino C1-C6Alkyl, amino halogen C1-C6Alkyl, hydroxyl C1-C6Alkyl, hydroxy halogeno C1-C6 Alkyl, sulfydryl C1-C6Alkyl, sulfydryl halo C1-C6Alkyl, cyano group C1-C6Alkyl, cyano halo C1-C6Alkyl, C1-C6Alkoxyl C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Halogenated alkoxy C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, Halo C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkylthio group halo C1-C6Alkyl, C1-C6Alkylamino radical C1-C6Alkyl, halo C1-C6Alkane Amido C1-C6Alkyl, C1-C6Alkylamino radical halo C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alcoxyl Base carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkylthiocarbonyl, halo C1-C6Alkylthiocarbonyl, C1-C6Alkylaminocarbonyl, Halo C1-C6Alkylaminocarbonyl, C1-C6Alkylamino radical thiocarbonyl, halo C1-C6Alkylamino radical thiocarbonyl, C1-C6Alkyl-carbonyl C1- C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1- C6Alkyl, C1-C6Alkylaminocarbonyl C1-C6Alkyl, halo C1-C6Alkylaminocarbonyl C1-C6Alkyl, C1-C6Alkylthiocarbonyl C1-C6 Alkyl, halo C1-C6Alkylthiocarbonyl C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkyl, substituted or unsubstituted virtue Base halo C1-C6Alkyl, substituted or unsubstituted aryloxy group C1-C6Alkyl, substituted or unsubstituted aryloxy group halo C1-C6Alkane Base, substituted or unsubstituted aryl amine C1-C6Alkyl, substituted or unsubstituted aryl amine halo C1-C6Alkyl, replacement do not take The heteroaryl C in generation1-C6Alkyl, substituted or unsubstituted heteroaryl halo C1-C6Alkyl, substituted or unsubstituted heteroaryloxy C1- C6Alkyl, substituted or unsubstituted heteroaryloxy halo C1-C6Alkyl, substituted or unsubstituted heteroaryl amido C1-C6Alkyl, replacement Or unsubstituted heteroaryl amido halo C1-C6Alkyl, substituted or unsubstituted aryl carbonyl C1-C6It is alkyl, substituted or unsubstituted Aryl carbonyl halo C1-C6Alkyl, substituted or unsubstituted aryloxycarbonyl C1-C6Alkyl, substituted or unsubstituted aryloxy group carbonyl Base halo C1-C6Alkyl, substituted or unsubstituted aryl amine carbonyl C1-C6Alkyl, substituted or unsubstituted aryl amine carbonyl halides generation C1-C6Alkyl, substituted or unsubstituted Heteroarylcarbonyl C1-C6Alkyl, substituted or unsubstituted Heteroarylcarbonyl halo C1-C6Alkane Base, substituted or unsubstituted Heteroaryloxycarbonyl C1-C6Alkyl, substituted or unsubstituted Heteroaryloxycarbonyl halo C1-C6Alkane Base, substituted or unsubstituted heteroaryl amino-carbonyl C1-C6Alkyl, substituted or unsubstituted heteroaryl amino-carbonyl halo C1-C6Alkane Base, substituted or unsubstituted aryl carbonyl, substituted or unsubstituted aryloxycarbonyl, substituted or unsubstituted aryl amine carbonyl, Substituted or unsubstituted aryl amine thiocarbonyl, substituted or unsubstituted Heteroarylcarbonyl, substituted or unsubstituted heteroaryloxy Carbonyl, substituted or unsubstituted heteroaryl amino-carbonyl, substituted or unsubstituted heteroaryl amido thiocarbonyl；
R2,R3May be the same or different, be respectively selected from H, halogen, CN, NO2、NH2、CONH2、C1-C6Alkyl, halo C1-C6Alkane Base, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkyl amine group, halo C1-C6Alkyl amine group, C1-C6Alkylthio group, halo C1-C6 Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6 Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkylaminocarbonyl, Halo C1-C6Alkylaminocarbonyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkoxyl, halo C1-C6Alkyl-carbonyl C1-C6Alkoxyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkoxyl, halo C1-C6Alkoxy carbonyl C1-C6It is alkoxyl, unsubstituted or by the amino C of following substituent group1-C6Alkane Base, aryl, aryloxy group, aryl C1-C6Alkyl, aryl C1-C6Alkoxyl, heteroaryl, heteroaryl C1-C6Alkyl, heteroaryl C1-C6 Alkoxyl：Halogen, cyano group, nitro, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6 Alkylthio group or C1-C6Alkyl-carbonyl；
R4Selected from H, halogen, CN, CONH2、CSNH2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8 Cycloalkyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynes Base, C2-C6Alkenyloxy group, halo C2-C6Alkenyloxy group, C2-C6Alkynyloxy group, halo C2-C6Alkynyloxy group, cyano group C1-C6Alkyl, cyano group halogen For C1-C6Alkyl, cyano group C1-C6Alkoxyl, cyano halo C1-C6Alkoxyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkane Epoxide C1-C6Alkyl, C1-C6Alkyl sulfinyl epoxide, halo C1-C6Alkyl sulfinyl epoxide, C1-C6Alkyl sulfinyl amido, halogen For C1-C6Alkyl sulfinyl amido, C1-C6Alkyl sulfinyl epoxide C1-C6Alkyl, halo C1-C6Alkyl sulfinyl epoxide C1-C6 Alkyl, C1-C6Alkyl sulfinyl amido C1-C6Alkyl, halo C1-C6Alkyl sulfinyl amido C1-C6Alkyl, C1-C6Alkane sulfonyl Epoxide, halo C1-C6Alkane sulfonyl epoxide, C1-C6Alkane sulfonyl amido, halo C1-C6Alkane sulfonyl amido, C1-C6Alkane sulfonyl Epoxide C1-C6Alkyl, halo C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, C1-C6Alkane sulfonyl amido C1-C6Alkyl, halo C1-C6 Alkane sulfonyl amido C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6 Alkoxy carbonyl, C1-C6Alkylaminocarbonyl, halo C1-C6Alkylaminocarbonyl, C1-C6Alkoxy carbonyl C1-C6Alkoxyl, halo C1-C6Alkoxy carbonyl C1-C6Alkoxyl, C1-C6Alkylaminocarbonyl C1-C6Alkoxyl, halo C1-C6Alkylaminocarbonyl C1-C6Alkane Epoxide, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkylaminocarbonyl C1-C6Alkane Base, halo C1-C6Alkylaminocarbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkane Base, C1-C6Alkyl-carbonyl C1-C6Alkoxyl, halo C1-C6Alkyl-carbonyl C1-C6Alkoxyl, substituted or unsubstituted aryl C1-C6 Alkyl, substituted or unsubstituted aryl halide are for C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkoxyl, replacement do not take The aryl halide in generation is for C1-C6Alkoxyl, substituted or unsubstituted heteroaryl C1-C6Alkyl, substituted or unsubstituted heteroaryl halo C1-C6Alkyl, substituted or unsubstituted heteroaryl C1-C6Alkoxyl, substituted or unsubstituted heteroaryl halo C1-C6Alkoxyl；
R5,R6May be the same or different, be respectively selected from H, halogen, CN, NO2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Ring Alkyl, halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkoxyl, Halo C1-C6Alkoxyl, C1-C6Alkylthio group, halo C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, Halo C1-C6Alkoxy carbonyl, C1-C6Alkyl amino, C2-C6Dialkyl amido, C3-C8Cycloalkyl amino, C1-C6Alkyl amino Carbonyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkoxy C1-C6Alkoxyl, halo C1- C6Alkoxy C1-C6Alkoxyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkane Epoxide carbonyl C1-C6Alkoxyl, halo C1-C6Alkoxy carbonyl C1-C6Alkoxyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1- C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkoxyl, halo C1-C6Alkyl-carbonyl C1-C6Alkoxyl；
R7Selected from H；C1-C6Alkyl, C3-C8Cycloalkyl, C2-C6Thiazolinyl, C2-C6Alkynyl, each of which optionally by one or Multiple following substituent groups replace：Halogen, CN, NO2、OH、C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxyl, halo C1- C6Alkoxyl, C1-C6Alkylthio group, halo C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane Sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, phenyl, phenoxy group, 5 yuan of hetero-aromatic rings and 6 First hetero-aromatic ring；Phenyl, phenoxy group, 5 yuan of hetero-aromatic rings and 6 yuan of hetero-aromatic rings each optionally independent are taken selected from following by 1 to 3 Replace for base：C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halo C2-C6 Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, halogen, CN, NO2、C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl ammonia Base, C2-C6Dialkyl amido, C3-C8Cycloalkyl amino, C1-C6(alkyl) (cycloalkyl) amino, C1-C6Alkyl-carbonyl, C1-C6Alkane Epoxide carbonyl, C1-C6Alkyl amino-carbonyl, C2-C8Dialkyl amino carbonyl；C1-C6Alkoxyl；C1-C6Alkyl amino；C2-C6Two Alkyl amino；C3-C8Cycloalkyl amino；C1-C6Alkyl-carbonyl or C1-C6Alkoxy carbonyl；
R8Selected from H, OH, NH2、C(CH3)2CH2S(O)(NH)CH3、C(CH3)2CH2S(O)(NCN)CH3、C1-C6Alkyl, halogen For C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2- C6Alkynyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C3-C8Cycloalkyl C1-C6Alkyl, halo C3-C8Cycloalkyl C1-C6Alkyl, C3-C8Oxacycloalkyl, C3-C8Oxacycloalkyl C1-C6 Alkyl, hydroxyl C1-C6Alkyl, C1-C6Alkyl amine group C1-C6Alkyl, two (C1-C6Alkyl) amido C1-C6Alkyl, replacement do not take The pyridine radicals C in generation1-C6Alkyl, substituted or unsubstituted thiazolyl C1-C6Alkyl, substituted or unsubstituted pyridyloxy C1-C6Alkane Base, substituted or unsubstituted pyridine thio C1-C6Alkyl, substituted or unsubstituted pyridine amido C1-C6Alkyl, replacement do not take The morpholine base in generation, replace or or unsubstituted piperazinyl, morpholine base C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, C1-C6 Alkyl sulfoxide base C1-C6Alkyl, C1-C6Alkyl sulfuryl C1-C6Alkyl, C1-C6Alkyl carbonyl epoxide, C1-C6Alkoxy carbonyl oxygen Base, C1-C6Alkylaminocarbonyl epoxide, C1-C6Alkyl sulphonyl epoxide, halo C1-C6Alkyl sulphonyl epoxide, C1-C6Alkyl sulfonyl Amido, halo C1-C6Alkylsulfonamido, substituted or unsubstituted aryl carbonyl epoxide, substituted or unsubstituted aryloxycarbonyl It is epoxide, substituted or unsubstituted aryl amine carbonyl epoxide, substituted or unsubstituted Heteroarylcarbonyl epoxide, substituted or unsubstituted Heteroaryloxycarbonyl epoxide, substituted or unsubstituted heteroaryl amino-carbonyl epoxide, C1-C6Alkylamino radical thiocarbonyl epoxide, replace or Unsubstituted aryl amine thiocarbonyl epoxide, substituted or unsubstituted aryl C1-C6Alkoxyl, substituted or unsubstituted pyridine radicals C1-C6Alkoxyl, substituted or unsubstituted thiazolyl C1-C6Alkoxyl, C1-C6Alkyl-carbonyl amido, C1-C6Alkoxy carbonyl amine Base, C1-C6Alkylaminocarbonyl amido, C1-C6Alkylamino radical thiocarbonyl amido, substituted or unsubstituted aryl carbonyl amido, replacement Or unsubstituted aryloxycarbonyl amido, substituted or unsubstituted aryl amine carbonylamino, substituted or unsubstituted aryl amine sulfur For carbonylamino, substituted or unsubstituted Heteroarylcarbonyl amido, substituted or unsubstituted Heteroaryloxycarbonyl amido, replace or Unsubstituted heteroaryl amino-carbonyl amido, substituted or unsubstituted heteroaryl amido thiocarbonyl amido, amino carbonyl amido, C1-C6 Alkylamino radical, two (C1-C6) alkylamino radical, substituted or unsubstituted aryl C1-C6Alkylamino radical, substituted or unsubstituted pyridine radicals C1-C6 Alkylamino radical, substituted or unsubstituted thiazolyl C1-C6Alkylamino radical, N (t-Bu) (COPh), N=CHN (CH3)2, N=C (CH3)2、N =CHCF3, N=CHPh, N=CH (2-Py), N=CH (3-Py), N=CH (4-Py)；
R9Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxyl, Halo C1-C6Alkoxyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl-carbonyl, halogen For C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkylaminocarbonyl, halo C1-C6Alkane Amino-carbonyl, C1-C6Alkylamino radical thiocarbonyl, halo C1-C6Alkylamino radical thiocarbonyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6 Alkylaminocarbonyl C1-C6Alkyl, halo C1-C6Alkylaminocarbonyl C1-C6Alkyl, substituted or unsubstituted aryl carbonyl, replacement or Unsubstituted aryloxycarbonyl, substituted or unsubstituted Heteroarylcarbonyl, substituted or unsubstituted Heteroaryloxycarbonyl, replacement or Unsubstituted aryl amine carbonyl, substituted or unsubstituted aryl amine thiocarbonyl, C1-C6Alkyl sulfinyl, halo C1-C6Alkane is sub- Sulfonyl, C1-C6Alcoxyl sulfinyl, halo C1-C6Alcoxyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alcoxyl sulfonyl, halo C1-C6Alcoxyl sulfonyl；
The more preferred compound of the present invention is：In formula I
A, B may be the same or different, and be respectively and independently selected from O, S or NRa；Ra=H, CN, NO2、NH2Or NHCH3；
X is selected from H, halogen, CN, NO2、NH2, CHO, CH=NOCH3, CH=NNHCH3Or CH=NN (CH3)2；
Y is selected from O, S, S (=O), S (=NRb), S (=O)n(=NRb)2-n(n=1 or 2；Rb=H, CN, NO2) or NRc；Rc =H, CN, NO2、NH2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxyl, halogen For C1-C6Alkoxyl, C1-C6Alkylamino radical, halo C1-C6Alkylamino radical, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1- C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6 Alkoxy carbonyl C1-C6Alkyl, substituted or unsubstituted aryl carbonyl, substituted or unsubstituted aryloxycarbonyl, replacement do not take The Heteroarylcarbonyl in generation, substituted or unsubstituted Heteroaryloxycarbonyl, substituted or unsubstituted aryl amine carbonyl, replacement do not take The aryl amine thiocarbonyl in generation, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alcoxyl sulfinyl, halo C1-C6Alcoxyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alcoxyl sulfonyl, halo C1-C6Alcoxyl Sulfonyl；
Z is selected from N or CRd；Rd=H, halogen or NO2；
R1Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halogen For C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alcoxyl Sulfinyl, halo C1-C6Alcoxyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alcoxyl sulfonyl, Halo C1-C6Alcoxyl sulfonyl, amino C1-C6Alkyl, hydroxyl C1-C6Alkyl, sulfydryl C1-C6Alkyl, cyano group C1-C6Alkyl, cyano group Halo C1-C6Alkyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, Halo C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkylamino radical C1-C6Alkyl, halo C1-C6Alkylamino radical C1-C6Alkyl, C1-C6Alkyl oxycarbonyl Base, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkylthiocarbonyl, halo C1- C6Alkylthiocarbonyl, C1-C6Alkylaminocarbonyl, halo C1-C6Alkylaminocarbonyl, C1-C6Alkylamino radical thiocarbonyl, halo C1-C6Alkane Amido thiocarbonyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1- C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkylaminocarbonyl C1-C6Alkyl, halo C1-C6Alkylaminocarbonyl C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkyl, substituted or unsubstituted aryloxy group C1-C6Alkyl, replacement do not take The aryl amine C in generation1-C6Alkyl, substituted or unsubstituted heteroaryl C1-C6Alkyl, substituted or unsubstituted heteroaryloxy C1-C6Alkane Base, substituted or unsubstituted heteroaryl amido C1-C6Alkyl, substituted or unsubstituted aryl carbonyl C1-C6Alkyl, replacement do not take Aryloxycarbonyl C in generation1-C6Alkyl, substituted or unsubstituted aryl amine carbonyl C1-C6Alkyl, substituted or unsubstituted heteroaryl Carbonyl C1-C6Alkyl, substituted or unsubstituted Heteroaryloxycarbonyl C1-C6Alkyl, substituted or unsubstituted heteroaryl amino-carbonyl C1- C6Alkyl, substituted or unsubstituted aryl carbonyl, substituted or unsubstituted aryloxycarbonyl, substituted or unsubstituted aryl amine carbonyl Base, substituted or unsubstituted aryl amine thiocarbonyl, substituted or unsubstituted Heteroarylcarbonyl, substituted or unsubstituted heteroaryl oxygen Base carbonyl, substituted or unsubstituted heteroaryl amino-carbonyl, substituted or unsubstituted heteroaryl amido thiocarbonyl；
R2,R3May be the same or different, be respectively selected from H, halogen, CN, NO2、NH2、CONH2、C1-C6Alkyl, halo C1-C6Alkane Base, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkyl amine group, halo C1-C6Alkyl amine group, C1-C6Alkylthio group, halo C1-C6 Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6 Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkylaminocarbonyl, Halo C1-C6Alkylaminocarbonyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkoxyl, halo C1-C6Alkyl-carbonyl C1-C6Alkoxyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkoxyl, halo C1-C6Alkoxy carbonyl C1-C6Alkoxyl；
R4Selected from H, halogen, CN, CONH2、CSNH2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8 Cycloalkyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynes Base, C2-C6Alkenyloxy group, halo C2-C6Alkenyloxy group, C2-C6Alkynyloxy group, halo C2-C6Alkynyloxy group, cyano group C1-C6Alkyl, cyano group halogen For C1-C6Alkyl, cyano group C1-C6Alkoxyl, cyano halo C1-C6Alkoxyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkane Epoxide C1-C6Alkyl, C1-C6Alkyl sulfinyl epoxide, halo C1-C6Alkyl sulfinyl epoxide, C1-C6Alkyl sulfinyl amido, halogen For C1-C6Alkyl sulfinyl amido, C1-C6Alkyl sulfinyl epoxide C1-C6Alkyl, halo C1-C6Alkyl sulfinyl epoxide C1-C6 Alkyl, C1-C6Alkyl sulfinyl amido C1-C6Alkyl, halo C1-C6Alkyl sulfinyl amido C1-C6Alkyl, C1-C6Alkane sulfonyl Epoxide, halo C1-C6Alkane sulfonyl epoxide, C1-C6Alkane sulfonyl amido, halo C1-C6Alkane sulfonyl amido, C1-C6Alkane sulfonyl Epoxide C1-C6Alkyl, halo C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, C1-C6Alkane sulfonyl amido C1-C6Alkyl, halo C1-C6 Alkane sulfonyl amido C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6 Alkoxy carbonyl, C1-C6Alkylaminocarbonyl, halo C1-C6Alkylaminocarbonyl, C1-C6Alkoxy carbonyl C1-C6Alkoxyl, halo C1-C6Alkoxy carbonyl C1-C6Alkoxyl, C1-C6Alkylaminocarbonyl C1-C6Alkoxyl, halo C1-C6Alkylaminocarbonyl C1-C6Alkane Epoxide, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkylaminocarbonyl C1-C6Alkane Base, halo C1-C6Alkylaminocarbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkane Base, C1-C6Alkyl-carbonyl C1-C6Alkoxyl, halo C1-C6Alkyl-carbonyl C1-C6Alkoxyl, substituted or unsubstituted aryl C1-C6 Alkyl, substituted or unsubstituted aryl C1-C6Alkoxyl, substituted or unsubstituted heteroaryl C1-C6Alkyl, replacement or unsubstituted Heteroaryl C1-C6Alkoxyl；
R5,R6May be the same or different, be respectively selected from H, halogen, CN, NO2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Ring Alkyl, halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkoxyl, Halo C1-C6Alkoxyl, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulphur Acyl group, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkane Base amino, C2-C6Dialkyl amido, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkoxyl C1-C6Alkoxyl, halo C1-C6Alkoxy C1-C6Alkoxyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxyl carbonyl Base C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkoxyl, halo C1-C6Alkoxy carbonyl C1-C6Alkoxyl, C1-C6Alkyl oxycarbonyl Base C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkoxyl, halo C1-C6Alkyl-carbonyl C1-C6Alkoxyl；
R7Selected from H；C1-C6Alkyl, C3-C8Cycloalkyl, C2-C6Thiazolinyl, C2-C6Alkynyl, each of which optionally by one or Multiple following substituent groups replace：Halogen, CN, NO2、OH、C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxyl, halo C1- C6Alkoxyl, C1-C6Alkylthio group, halo C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane Sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, phenyl, phenoxy group, 5 yuan of hetero-aromatic rings and 6 First hetero-aromatic ring；Phenyl, phenoxy group, 5 yuan of hetero-aromatic rings and 6 yuan of hetero-aromatic rings each optionally independent are taken selected from following by 1 to 3 Replace for base：C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halo C2-C6 Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, halogen, CN, NO2、C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl ammonia Base, C2-C6Dialkyl amido, C3-C8Cycloalkyl amino, C1-C6(alkyl) (cycloalkyl) amino, C1-C6Alkyl-carbonyl, C1-C6Alkane Epoxide carbonyl, C1-C6Alkyl amino-carbonyl, C2-C8Dialkyl amino carbonyl；
R8Selected from H, OH, NH2、C(CH3)2CH2S(O)(NH)CH3、C(CH3)2CH2S(O)(NCN)CH3、C1-C6Alkyl, halogen For C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2- C6Alkynyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkoxy C1-C6Alkyl, C3-C8Cycloalkyl C1-C6Alkyl, C3-C8 Oxacycloalkyl C1-C6Alkyl, halo C3-C8Cycloalkyl C1-C6Alkyl, hydroxyl C1-C6Alkyl, C1-C6Alkyl amine group C1-C6Alkane Base, two (C1-C6Alkyl) amido C1-C6Alkyl, substituted or unsubstituted pyridine radicals C1-C6Alkyl, substituted or unsubstituted thiazole Base C1-C6Alkyl, substituted or unsubstituted pyridyloxy C1-C6Alkyl, substituted or unsubstituted pyridine thio C1-C6Alkyl, take Generation or unsubstituted pyridine amido C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkyl sulfoxide base C1-C6Alkyl, C1-C6 Alkyl sulfuryl C1-C6Alkyl, C1-C6Alkyl carbonyl epoxide, C1-C6Alkoxy-carbonyl oxy, C1-C6Alkylaminocarbonyl epoxide, C1- C6Alkyl sulphonyl epoxide, halo C1-C6Alkyl sulphonyl epoxide, C1-C6Alkylsulfonamido, halo C1-C6Alkyl sulfonamide Base, substituted or unsubstituted aryl carbonyl epoxide, substituted or unsubstituted aryloxycarbonyl epoxide, substituted or unsubstituted heteroaryl Base carbonyl epoxide, substituted or unsubstituted Heteroaryloxycarbonyl epoxide, C1-C6Alkylamino radical thiocarbonyl epoxide, replacement or unsubstituted Aryl amine thiocarbonyl epoxide, substituted or unsubstituted aryl C1-C6Alkoxyl, substituted or unsubstituted pyridine radicals C1-C6Alkane Epoxide, substituted or unsubstituted thiazolyl C1-C6Alkoxyl, C1-C6Alkyl-carbonyl amido, C1-C6Alkoxycarbonylamino, C1-C6 Alkylaminocarbonyl amido, C1-C6Alkylamino radical thiocarbonyl amido, substituted or unsubstituted aryl carbonyl amido, replacement or unsubstituted Aryloxycarbonyl amido, substituted or unsubstituted aryl amine carbonylamino, substituted or unsubstituted aryl amine thiocarbonyl amine Base, amino carbonyl amido, C1-C6Alkylamino radical, two (C1-C6) alkylamino radical, substituted or unsubstituted aryl C1-C6Alkylamino radical, replacement Or unsubstituted pyridine radicals C1-C6Alkylamino radical, substituted or unsubstituted thiazolyl C1-C6Alkylamino radical；
R9Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halogen For C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxyl carbonyl Base, halo C1-C6Alkoxy carbonyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkane Epoxide carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, substituted or unsubstituted aryl carbonyl, replacement or not Substituted aryloxycarbonyl, substituted or unsubstituted Heteroarylcarbonyl, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl；
Preferred compound is the present invention again：In formula I
A, B may be the same or different, and be respectively and independently selected from O, S or NRa；Ra=H, CN, NO2；
X is selected from H, halogen, CN, NO2、NH2Or CHO；
Y is selected from O, S, S (=O), S (=NRb), S (=O)n(=NRb)2-n(n=1 or 2；Rb=H, CN, NO2) or NRc；Rc =H, CN, NO2、NH2、C1-C6Alkyl, halo C1-C6Alkyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6 Alkynyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkane Sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl；
Z is selected from N or CRd；Rd=H, halogen or NO2；
R1Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2- C6Alkynyl, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, cyano group C1-C6Alkyl, cyano halo C1-C6Alkyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkane Sulfenyl C1-C6Alkyl, halo C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alcoxyl Base carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1- C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkyl, Substituted or unsubstituted heteroaryl C1-C6Alkyl, substituted or unsubstituted aryl carbonyl C1-C6It is alkyl, substituted or unsubstituted miscellaneous Aryl carbonyl C1-C6Alkyl；
R2,R3May be the same or different, be respectively selected from H, halogen, CN, NO2、NH2、CONH2、C1-C6Alkyl, halo C1-C6Alkane Base, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkyl amine group, halo C1-C6Alkyl amine group, C1-C6Alkylthio group, halo C1-C6 Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6 Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl；
R4Selected from H, halogen, CN, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C2-C6 Alkenyloxy group, halo C2-C6Alkenyloxy group, C2-C6Alkynyloxy group, halo C2-C6Alkynyloxy group, cyano group C1-C6Alkyl, cyano halo C1-C6Alkane Base, cyano group C1-C6Alkoxyl, cyano halo C1-C6Alkoxyl, C1-C6Alkyl sulfinyl epoxide, halo C1-C6Alkyl sulfinyl oxygen Base, C1-C6Alkyl sulfinyl epoxide C1-C6Alkyl, halo C1-C6Alkyl sulfinyl epoxide C1-C6Alkyl, C1-C6Alkane sulfonyl oxygen Base, halo C1-C6Alkane sulfonyl epoxide, C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, halo C1-C6Alkane sulfonyl epoxide C1-C6Alkane Base, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl；
R5,R6May be the same or different, be respectively selected from H, halogen, CN, NO2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Ring Alkyl, halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkoxyl, Halo C1-C6Alkoxyl, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulphur Acyl group, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl；
R7Selected from H；C1-C6Alkyl, C3-C8Cycloalkyl, C2-C6Thiazolinyl, C2-C6Alkynyl, each of which optionally by one or Multiple following substituent groups replace：Halogen, CN, NO2、OH、C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxyl, halo C1- C6Alkoxyl, C1-C6Alkylthio group, halo C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane Sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, phenyl, phenoxy group, 5 yuan of hetero-aromatic rings and 6 First hetero-aromatic ring；
R8Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halogen For C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkoxy C1-C6Alkane Base, C1-C6Alkylthio group C1-C6Alkyl, C3-C8Cycloalkyl C1-C6Alkyl, halo C3-C8Cycloalkyl C1-C6Alkyl, hydroxyl C1-C6Alkane Base, two (C1-C6Alkyl) amido C1-C6Alkyl, C3-C8Oxacycloalkyl C1-C6Alkyl, substituted or unsubstituted pyridine radicals C1-C6 Alkyl, substituted or unsubstituted thiazolyl C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkyl sulfoxide base C1-C6Alkane Base, C1-C6Alkyl sulfuryl C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkoxyl, substituted or unsubstituted pyridine radicals C1- C6Alkoxyl, substituted or unsubstituted thiazolyl C1-C6Alkoxyl；
R9Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alcoxyl Base carbonyl, halo C1-C6Alkoxy carbonyl, the substituted or unsubstituted Heteroarylcarbonyl of substituted or unsubstituted aryl carbonyl, C1- C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl；
The further preferred compound of the present invention is：In formula I
A, B may be the same or different, and be respectively and independently selected from O, S or NRa；Ra=H or CN；
X is selected from H, halogen or CN；
Y is selected from O, S, S (=O), S (=O)2Or NRc；Rc=H or CN；
Z is selected from N or CRd；Rd=H, halogen or NO2；
R1Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6 Alkyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl sulfinyl, halo C1-C6Alkane Sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, cyano group C1-C6Alkyl, cyano halo C1-C6Alkyl, C1-C6Alkane Epoxide carbonyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, substituted or unsubstituted aryl C1-C6 Alkyl, substituted or unsubstituted heteroaryl C1-C6Alkyl；
R2,R3May be the same or different, be respectively selected from H, halogen, CN, NO2、NH2、CONH2、C1-C6Alkyl, halo C1-C6Alkane Base, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkylthio group, halo C1-C6Alkylthio group；
R4Selected from H, halogen, CN, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, cyano group C1-C6Alkyl, cyano group C1-C6Alkoxyl, cyano halo C1-C6Alkoxyl, C1-C6Alkane sulfonyl epoxide, halo C1-C6Alkane sulphonyl Base epoxide, C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, halo C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, C1-C6Alkoxyl carbonyl Base；
R5,R6May be the same or different, be respectively selected from H, halogen, CN, CF3Or NO2；
R7Selected from H；C1-C6Alkyl, C3-C8Cycloalkyl, C2-C6Thiazolinyl or C2-C6Alkynyl；
R8Selected from H,C1-C6Alkyl, halo C1-C6Alkyl, C2-C6Thiazolinyl, C2-C6Alkynyl, C3-C8Cycloalkyl, C (CH3)2CH2SCH3、CH2CH2CH2N(CH3)2、CH(CH3)CH2OH、
R9Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alcoxyl Base carbonyl or halo C1-C6Alkoxy carbonyl；
Present invention compound still further preferably is：In formula I
A, B may be the same or different, and be respectively and independently selected from O, S or NH；
X is selected from H, F, Cl, Br, I or CN；
Y is selected from O, S, S (=O), S (=O)2Or NRc；Rc=H or CN；
Z is selected from N or CRd；Rd=H, F, Cl or Br；
R1Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6 Alkyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, cyano group C1-C6Alkyl, cyano halo C1-C6 Alkyl, CH2Ph、
R2,R3May be the same or different, be respectively selected from H, F, Cl, Br, I, CN, C1-C6Alkyl, halo C1-C6Alkyl, C2-C6Alkene Base, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl；
R4Selected from H, F, Cl, Br, I, C1-C3Alkoxyl, halo C1-C3Alkoxyl, cyano group C1-C3Alkyl, cyano group C1-C3Alkane Epoxide or CN；
R5,R6May be the same or different, be respectively selected from H, F, Cl, Br, I, CN, CF3Or NO2；
R7Selected from H or C1-C6Alkyl；
R8Selected from H, CH3、CH2CH3、CH(CH3)2、C(CH3)3、CH2CH=CH2、CH2C≡CH、C(CH3)2C≡CH、C (CH3)2CH2SCH3、CH2CH2Cl、CH2CH2Br, cyclopropyl, CH2CH2CH2N(CH3)2、CH (CH3)CH2OH、
R9Selected from H or C1-C6Alkyl；
Present invention compound still more preferably is：In formula I
A, B may be the same or different, and be respectively and independently selected from O or S；
X is selected from H, F, Cl or CN；
Y is selected from O, S, S (=O) or S (=O)2；
Z is selected from N or CRd；Rd=H, F or Cl；
R1Selected from H, CH3、CH2CH3、CH2CH2CH3、CH(CH3)2、C(CH3)3、CF3、CF2H、CFH2、CCl3、CCl2H、 CClH2、CFClH、CF2CF2H、CH2CF3、CH2OCH3、CH2CH=CH2、CH2CH=CHCl, CH2C≡CH、CH2C≡CI、 CH2CN、CH2Ph、
R2,R3May be the same or different, be respectively selected from H, F, Cl, Br, CN, CH3、CH2CH3、CH2CH2CH3、CH(CH3)2、 CH2F、CF2H、CF3、CH2Cl、CCl2H、CCl3、CFClH；
R4Selected from F, Cl, Br, OCH3、OCH2CH3、OCF3、OCHF2、OCH2F、OCCl3、OCHCl2、OCH2Cl、OCHFCl、 OCF2CF2H、OCH2CF3、CH2CN、OCH2CN or CN；
R5,R6May be the same or different, be respectively selected from H, F, Cl, Br, CF3Or CN；
R7Selected from H, CH3、CH2CH3、CH2CH2CH3、CH(CH3)2、C(CH3)3；
R8Selected from H, CH3、CH2CH3、CH(CH3)2、C(CH3)3、CH2CH=CH2、CH2C≡CH、C(CH3)2C≡CH、C (CH3)2CH2SCH3、CH2CH2Cl、CH2CH2Br, cyclopropyl, CH2CH2CH2N(CH3)2、CH (CH3)CH2OH、
R9Selected from H or CH3；
In the definition of compound of Formula I given above, collect term used and be typically defined as follows：
It is unsubstituted to represent that all substituent groups are all hydrogen.
In substituted amido, the number of substituent group can be 1～2.
Halogen：Refer to fluorine, chlorine, bromine or iodine.
Alkyl：Straight or branched alkyl, such as methyl, ethyl, propyl group, isopropyl or the tert-butyl group.
Haloalkyl：Straight or branched alkyl, the hydrogen atom on these alkyl partly or entirely can be taken by halogen atom Generation.For example, haloalkyl such as chloromethyl, dichloromethyl, trichloromethyl, methyl fluoride, difluoromethyl or trifluoromethyl.
Alkoxyl：Straight or branched alkyl, Jing oxygen atoms are bonded and are connected in structure.
Halogenated alkoxy：Straight or branched alkoxyl, the hydrogen atom on these alkoxyls can be partly or entirely former by halogen Son is replaced.For example, halogenated alkoxy such as chloromethane epoxide, dichloro methoxyl group, trichloromethoxy, fluorine methoxyl group, difluoromethoxy Base, trifluoromethoxy, chlorine fluorine methoxyl group or trifluoro ethoxy.
Thiazolinyl：Straight or branched simultaneously can there are double bond, such as vinyl or pi-allyl on any position.
Alkynyl：Straight or branched simultaneously can there are three keys, such as acetenyl or propargyl on any position.
Aryl moiety in aryl and aralkyl, aromatic yl alkenyl, sweet-smelling alkynyl, aryloxy group and aryloxy alkyl includes benzene Base or naphthyl.
In the present invention, indication heteroaryl is containing heteroatomic 5 yuan of rings of one or more N, O, S or 6 yuan of rings.Such as pyridine, furan Mutter, pyrimidine, pyrazine, pyridazine, triazine, quinoline or benzofuran.
The compound of the present invention can be present as one or more stereoisomer.It will be appreciated by those skilled in the art that When concentration is big for other stereoisomers for a kind of stereoisomer, or work as itself and other Enantiomer separations When, possibility is more active and/or may show favourable effect.In addition, those skilled in the art instruct and how to separate, be enriched with And/or optionally prepare the stereoisomer.Therefore, the present invention includes the change selected from formula I, its N- oxide or its salt Compound.The compound of the present invention can be as the mixture of stereoisomer, single stereoisomer or as optical forms Exist.
The present invention can be illustrated with the compound that table 1 below-table 260 is listed, but does not limit the present invention.
Table 1, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCH3When, choose as follows Compound, numbering are 1-1～1-709
Table 2, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCH3When, choose as The compound of 1 identical substituent group of table, numbering is 2-1～2-709.
Table 3, A=O, B=O, X=H, Z=N, R2=Cl, R3=F, R7=H, R9=H, YR1=OCH3When, choose such as table The compound of 1 identical substituent group, numbering is 3-1～3-709.
Table 4, A=O, B=O, X=H, Z=N, R2=Cl, R3=Br, R7=H, R9=H, YR1=OCH3When, choose as The compound of 1 identical substituent group of table, numbering is 4-1～4-709.
Table 5, A=O, B=O, X=H, Z=N, R2=Cl, R3=CF3,R7=H, R9=H, YR1=OCH3When, choose as The compound of 1 identical substituent group of table, numbering is 5-1～5-709.
Table 6, A=O, B=O, X=H, Z=N, R2=Cl, R3=H, R7=H, R9=H, YR1=OCH3When, choose such as table The compound of 1 identical substituent group, numbering is 6-1～6-709.
Table 7, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCH3When, choose as The compound of 1 identical substituent group of table, numbering is 7-1～7-709
Table 8, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCH3When, choose as The compound of 1 identical substituent group of table, numbering is 8-1～8-709.
Table 9, A=O, B=O, X=H, Z=N, R2=CN, R3=F, R7=H, R9=H, YR1=OCH3When, choose such as table The compound of 1 identical substituent group, numbering is 9-1～9-709.
Table 10, A=O, B=O, X=H, Z=N, R2=CN, R3=Br, R7=H, R9=H, YR1=OCH3When, choose as The compound of 1 identical substituent group of table, numbering is 10-1～10-709.
Table 11, A=O, B=O, X=H, Z=N, R2=CN, R3=CF3,R7=H, R9=H, YR1=OCH3When, choose such as With the compound of 1 identical substituent group of table, numbering is 11-1～11-709.
Table 12, A=O, B=O, X=H, Z=N, R2=CN, R3=H, R7=H, R9=H, YR1=OCH3When, choose as The compound of 1 identical substituent group of table, numbering is 12-1～12-709.
Table 13, A=O, B=O, X=H, Z=N, R2=Br, R3=Cl, R7=H, R9=H, YR1=OCH3When, choose as The compound of 1 identical substituent group of table, numbering is 13-1～13-709.
Table 14, A=O, B=O, X=H, Z=N, R2=Br, R3=CH3,R7=H, R9=H, YR1=OCH3When, choose such as With the compound of 1 identical substituent group of table, numbering is 14-1～14-709.
Table 15, A=O, B=O, X=H, Z=N, R2=Br, R3=F, R7=H, R9=H, YR1=OCH3When, choose as The compound of 1 identical substituent group of table, numbering is 15-1～15-709.
Table 16, A=O, B=O, X=H, Z=N, R2=Br, R3=Br, R7=H, R9=H, YR1=OCH3When, choose as The compound of 1 identical substituent group of table, numbering is 16-1～16-709.
Table 17, A=O, B=O, X=H, Z=N, R2=Br, R3=CF3,R7=H, R9=H, YR1=OCH3When, choose such as With the compound of 1 identical substituent group of table, numbering is 17-1～17-709.
Table 18, A=O, B=O, X=H, Z=N, R2=Br, R3=H, R7=H, R9=H, YR1=OCH3When, choose as The compound of 1 identical substituent group of table, numbering is 18-1～18-709.
Table 19, A=O, B=O, X=H, Z=N, R2=F, R3=Cl, R7=H, R9=H, YR1=OCH3When, choose as The compound of 1 identical substituent group of table, numbering is 19-1～19-709.
Table 20, A=O, B=O, X=H, Z=N, R2=F, R3=CH3,R7=H, R9=H, YR1=OCH3When, choose as The compound of 1 identical substituent group of table, numbering is 20-1～20-709.
Table 21, A=O, B=O, X=H, Z=N, R2=F, R3=F, R7=H, R9=H, YR1=OCH3When, choose such as table The compound of 1 identical substituent group, numbering is 21-1～21-709.
Table 22, A=O, B=O, X=H, Z=N, R2=F, R3=Br, R7=H, R9=H, YR1=OCH3When, choose as The compound of 1 identical substituent group of table, numbering is 22-1～22-709.
Table 23, A=O, B=O, X=H, Z=N, R2=F, R3=CF3,R7=H, R9=H, YR1=OCH3When, choose as The compound of 1 identical substituent group of table, numbering is 23-1～23-709.
Table 24, A=O, B=O, X=H, Z=N, R2=F, R3=H, R7=H, R9=H, YR1=OCH3When, choose such as table The compound of 1 identical substituent group, numbering is 24-1～24-709.
Table 25, A=O, B=O, X=H, Z=N, R2=H, R3=Cl, R7=H, R9=H, YR1=OCH3When, choose as The compound of 1 identical substituent group of table, numbering is 25-1～25-709.
Table 26, A=O, B=O, X=H, Z=N, R2=H, R3=CH3,R7=H, R9=H, YR1=OCH3When, choose as The compound of 1 identical substituent group of table, numbering is 26-1～26-709.
Table 27, A=O, B=O, X=H, Z=N, R2=H, R3=F, R7=H, R9=H, YR1=OCH3When, choose such as table The compound of 1 identical substituent group, numbering is 27-1～27-709.
Table 28, A=O, B=O, X=H, Z=N, R2=H, R3=Br, R7=H, R9=H, YR1=OCH3When, choose as The compound of 1 identical substituent group of table, numbering is 28-1～28-709.
Table 29, A=O, B=O, X=H, Z=N, R2=H, R3=CF3,R7=H, R9=H, YR1=OCH3When, choose as The compound of 1 identical substituent group of table, numbering is 29-1～29-709.
Table 30, A=O, B=O, X=H, Z=N, R2=H, R3=H, R7=H, R9=H, YR1=OCH3When, choose such as table The compound of 1 identical substituent group, numbering is 30-1～30-709.
Table 31, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=SCH3When, choose as The compound of 1 identical substituent group of table, numbering is 31-1～31-709.
Table 32, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=SCH3When, choose such as With the compound of 1 identical substituent group of table, numbering is 32-1～32-709.
Table 33, A=O, B=O, X=H, Z=N, R2=Cl, R3=F, R7=H, R9=H, YR1=SCH3When, choose as The compound of 1 identical substituent group of table, numbering is 33-1～33-709.
Table 34, A=O, B=O, X=H, Z=N, R2=Cl, R3=Br, R7=H, R9=H, YR1=SCH3When, choose as The compound of 1 identical substituent group of table, numbering is 34-1～34-709.
Table 35, A=O, B=O, X=H, Z=N, R2=Cl, R3=CF3,R7=H, R9=H, YR1=SCH3When, choose such as With the compound of 1 identical substituent group of table, numbering is 35-1～35-709.
Table 36, A=O, B=O, X=H, Z=N, R2=Cl, R3=H, R7=H, R9=H, YR1=SCH3When, choose as The compound of 1 identical substituent group of table, numbering is 36-1～36-709.
Table 37, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=SCH3When, choose as The compound of 1 identical substituent group of table, numbering is 37-1～37-709.
Table 38, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=SCH3When, choose such as With the compound of 1 identical substituent group of table, numbering is 38-1～38-709.
Table 39, A=O, B=O, X=H, Z=N, R2=CN, R3=F, R7=H, R9=H, YR1=SCH3When, choose as The compound of 1 identical substituent group of table, numbering is 39-1～39-709.
Table 40, A=O, B=O, X=H, Z=N, R2=CN, R3=Br, R7=H, R9=H, YR1=SCH3When, choose as The compound of 1 identical substituent group of table, numbering is 40-1～40-709.
Table 41, A=O, B=O, X=H, Z=N, R2=CN, R3=CF3,R7=H, R9=H, YR1=SCH3When, choose such as With the compound of 1 identical substituent group of table, numbering is 41-1～41-709.
Table 42, A=O, B=O, X=H, Z=N, R2=CN, R3=H, R7=H, R9=H, YR1=SCH3When, choose as The compound of 1 identical substituent group of table, numbering is 42-1～42-709.
Table 43, A=O, B=O, X=H, Z=N, R2=Br, R3=Cl, R7=H, R9=H, YR1=SCH3When, choose as The compound of 1 identical substituent group of table, numbering is 43-1～43-709.
Table 44, A=O, B=O, X=H, Z=N, R2=Br, R3=CH3,R7=H, R9=H, YR1=SCH3When, choose such as With the compound of 1 identical substituent group of table, numbering is 44-1～44-709.
Table 45, A=O, B=O, X=H, Z=N, R2=Br, R3=F, R7=H, R9=H, YR1=SCH3When, choose as The compound of 1 identical substituent group of table, numbering is 45-1～45-709.
Table 46, A=O, B=O, X=H, Z=N, R2=Br, R3=Br, R7=H, R9=H, YR1=SCH3When, choose as The compound of 1 identical substituent group of table, numbering is 46-1～46-709.
Table 47, A=O, B=O, X=H, Z=N, R2=Br, R3=CF3,R7=H, R9=H, YR1=SCH3When, choose such as With the compound of 1 identical substituent group of table, numbering is 47-1～47-709.
Table 48, A=O, B=O, X=H, Z=N, R2=Br, R3=H, R7=H, R9=H, YR1=SCH3When, choose as The compound of 1 identical substituent group of table, numbering is 48-1～48-709.
Table 49, A=O, B=O, X=H, Z=N, R2=F, R3=Cl, R7=H, R9=H, YR1=SCH3When, choose as The compound of 1 identical substituent group of table, numbering is 49-1～49-709.
Table 50, A=O, B=O, X=H, Z=N, R2=F, R3=CH3,R7=H, R9=H, YR1=SCH3When, choose as The compound of 1 identical substituent group of table, numbering is 50-1～50-709.
Table 51, A=O, B=O, X=H, Z=N, R2=F, R3=F, R7=H, R9=H, YR1=SCH3When, choose such as table The compound of 1 identical substituent group, numbering is 51-1～51-709.
Table 52, A=O, B=O, X=H, Z=N, R2=F, R3=Br, R7=H, R9=H, YR1=SCH3When, choose as The compound of 1 identical substituent group of table, numbering is 52-1～52-709.
Table 53, A=O, B=O, X=H, Z=N, R2=F, R3=CF3,R7=H, R9=H, YR1=SCH3When, choose as The compound of 1 identical substituent group of table, numbering is 53-1～53-709.
Table 54, A=O, B=O, X=H, Z=N, R2=F, R3=H, R7=H, R9=H, YR1=SCH3When, choose such as table The compound of 1 identical substituent group, numbering is 54-1～54-709.
Table 55, A=O, B=O, X=H, Z=N, R2=H, R3=Cl, R7=H, R9=H, YR1=SCH3When, choose as The compound of 1 identical substituent group of table, numbering is 55-1～55-709.
Table 56, A=O, B=O, X=H, Z=N, R2=H, R3=CH3,R7=H, R9=H, YR1=SCH3When, choose as The compound of 1 identical substituent group of table, numbering is 56-1～56-709.
Table 57, A=O, B=O, X=H, Z=N, R2=H, R3=F, R7=H, R9=H, YR1=SCH3When, choose such as table The compound of 1 identical substituent group, numbering is 57-1～57-709.
Table 58, A=O, B=O, X=H, Z=N, R2=H, R3=Br, R7=H, R9=H, YR1=SCH3When, choose as The compound of 1 identical substituent group of table, numbering is 58-1～58-709.
Table 59, A=O, B=O, X=H, Z=N, R2=H, R3=CF3,R7=H, R9=H, YR1=SCH3When, choose as The compound of 1 identical substituent group of table, numbering is 59-1～59-709.
Table 60, A=O, B=O, X=H, Z=N, R2=H, R3=H, R7=H, R9=H, YR1=SCH3When, choose such as table The compound of 1 identical substituent group, numbering is 60-1～60-709.
Table 61, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=NHCH3When, choose such as With the compound of 1 identical substituent group of table, numbering is 61-1～61-709.
Table 62, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=NHCH3When, choose such as With the compound of 1 identical substituent group of table, numbering is 62-1～62-709.
Table 63, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=NHCH3When, choose such as With the compound of 1 identical substituent group of table, numbering is 63-1～63-709.
Table 64, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=NHCH3When, choose such as With the compound of 1 identical substituent group of table, numbering is 64-1～64-709.
Table 65, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=N (CH3)2When, choose Such as the compound of 1 identical substituent group of table, numbering is 65-1～65-709.
Table 66, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=N (CH3)2When, choose Such as the compound of 1 identical substituent group of table, numbering is 66-1～66-709.
Table 67, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=N (CH3)2When, choose Such as the compound of 1 identical substituent group of table, numbering is 67-1～67-709.
Table 68, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=N (CH3)2When, choose Such as the compound of 1 identical substituent group of table, numbering is 68-1～68-709.
Table 69, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCH2CH=CH2When, Choose such as the compound of 1 identical substituent group of table, numbering is 69-1～69-709.
Table 70, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCH2CH=CH2When, Choose such as the compound of 1 identical substituent group of table, numbering is 70-1～70-709.
Table 71, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCH2CH=CH2When, Choose such as the compound of 1 identical substituent group of table, numbering is 71-1～71-709.
Table 72, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCH2CH=CH2When, Choose such as the compound of 1 identical substituent group of table, numbering is 72-1～72-709.
Table 73, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCH2During C ≡ CH, choosing Take such as the compound of 1 identical substituent group of table, numbering is 73-1～73-709.
Table 74, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCH2During C ≡ CH, choosing Take such as the compound of 1 identical substituent group of table, numbering is 74-1～74-709.
Table 75, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCH2During C ≡ CH, choosing Take such as the compound of 1 identical substituent group of table, numbering is 75-1～75-709.
Table 76, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCH2During C ≡ CH, choosing Take such as the compound of 1 identical substituent group of table, numbering is 76-1～76-709.
Table 77, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCH2CH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 77-1～77-709.
Table 78, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCH2CH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 78-1～78-709.
Table 79, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCH2CH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 79-1～79-709.
Table 80, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCH2CH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 80-1～80-709.
Table 81, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCH (CH3)2When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 81-1～81-709.
Table 82, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCH (CH3)2When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 82-1～82-709.
Table 83, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCH (CH3)2When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 83-1～83-709.
Table 84, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCH (CH3)2When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 84-1～84-709.
Table 85, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCH2During CN, choose such as With the compound of 1 identical substituent group of table, numbering is 85-1～85-709.
Table 86, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCH2During CN, choose Such as the compound of 1 identical substituent group of table, numbering is 86-1～86-709.
Table 87, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCH2During CN, choose such as With the compound of 1 identical substituent group of table, numbering is 87-1～87-709.
Table 88, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCH2During CN, choose Such as the compound of 1 identical substituent group of table, numbering is 88-1～88-709.
Table 89, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCH2During Ph, choose such as With the compound of 1 identical substituent group of table, numbering is 89-1～89-709.
Table 90, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCH2During Ph, choose Such as the compound of 1 identical substituent group of table, numbering is 90-1～90-709.
Table 91, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCH2During Ph, choose such as With the compound of 1 identical substituent group of table, numbering is 91-1～91-709.
Table 92, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCH2During Ph, choose Such as the compound of 1 identical substituent group of table, numbering is 92-1～92-709.
Table 93, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCH2During F, choose such as With the compound of 1 identical substituent group of table, numbering is 93-1～93-709.
Table 94, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCH2During F, choose such as With the compound of 1 identical substituent group of table, numbering is 94-1～94-709.
Table 95, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCH2During F, choose such as With the compound of 1 identical substituent group of table, numbering is 95-1～95-709.
Table 96, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCH2During F, choose such as With the compound of 1 identical substituent group of table, numbering is 96-1～96-709.
Table 97, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCF2During H, choose such as With the compound of 1 identical substituent group of table, numbering is 97-1～97-709.
Table 98, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCF2During H, choose such as With the compound of 1 identical substituent group of table, numbering is 98-1～98-709.
Table 99, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCF2During H, choose such as With the compound of 1 identical substituent group of table, numbering is 99-1～99-709.
Table 100, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCF2During H, choose Such as the compound of 1 identical substituent group of table, numbering is 100-1～100-709.
Table 101, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCF3When, choose such as With the compound of 1 identical substituent group of table, numbering is 101-1～101-709.
Table 102, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCF3When, choose such as With the compound of 1 identical substituent group of table, numbering is 102-1～102-709.
Table 103, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCF3When, choose such as With the compound of 1 identical substituent group of table, numbering is 103-1～103-709.
Table 104, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCF3When, choose such as With the compound of 1 identical substituent group of table, numbering is 104-1～104-709.
Table 105, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCF2CF2During H, choosing Take such as the compound of 1 identical substituent group of table, numbering is 105-1～105-709.
Table 106, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCF2CF2During H, choosing Take such as the compound of 1 identical substituent group of table, numbering is 106-1～106-709.
Table 107, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCF2CF2During H, choosing Take such as the compound of 1 identical substituent group of table, numbering is 107-1～107-709.
Table 108, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCF2CF2During H, choosing Take such as the compound of 1 identical substituent group of table, numbering is 108-1～108-709.
Table 109, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCH2CF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 109-1～109-709.
Table 110, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCH2CF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 110-1～110-709.
Table 111, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCH2CF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 111-1～111-709.
Table 112, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCH2CF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 112-1～112-709.
Table 113, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCH2CO2CH3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 113-1～113-709.
Table 114, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCH2CO2CH3When, Choose such as the compound of 1 identical substituent group of table, numbering is 114-1～114-709.
Table 115, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCH2CO2CH3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 115-1～115-709.
Table 116, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCH2CO2CH3When, Choose such as the compound of 1 identical substituent group of table, numbering is 116-1～116-709.
Table 117, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCH2CONHCH3When, Choose such as the compound of 1 identical substituent group of table, numbering is 117-1～117-709.
Table 118, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCH2CONHCH3When, Choose such as the compound of 1 identical substituent group of table, numbering is 118-1～118-709.
Table 119, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCH2CONHCH3When, Choose such as the compound of 1 identical substituent group of table, numbering is 119-1～119-709.
Table 120, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCH2CONHCH3When, Choose such as the compound of 1 identical substituent group of table, numbering is 120-1～120-709.
Table 121, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCH2COCH3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 121-1～121-709.
Table 122, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCH2COCH3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 122-1～122-709.
Table 123, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCH2COCH3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 123-1～123-709.
Table 124, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCH2COCH3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 124-1～124-709.
Table 125, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OSOCH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 125-1～125-709
Table 126, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OSOCH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 126-1～126-709
Table 127, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OSOCH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 127-1～127-709
Table 128, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OSOCH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 128-1～128-709
Table 129, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OSO2CH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 129-1～129-709
Table 130, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OSO2CH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 130-1～130-709
Table 131, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OSO2CH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 131-1～131-709
Table 132, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OSO2CH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 132-1～132-709
Table 133, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCH2CH=CHCl When, to choose such as the compound of 1 identical substituent group of table, numbering is 133-1～133-709.
Table 134, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCH2CH=CHCl When, to choose such as the compound of 1 identical substituent group of table, numbering is 134-1～134-709.
Table 135, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCH2CH=CHCl When, to choose such as the compound of 1 identical substituent group of table, numbering is 135-1～135-709.
Table 136, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCH2CH=CHCl When, to choose such as the compound of 1 identical substituent group of table, numbering is 136-1～136-709.
Table 137, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCH2During C ≡ CI, choosing Take such as the compound of 1 identical substituent group of table, numbering is 137-1～137-709.
Table 138, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCH2During C ≡ CI, Choose such as the compound of 1 identical substituent group of table, numbering is 138-1～138-709.
Table 139, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCH2During C ≡ CI, choosing Take such as the compound of 1 identical substituent group of table, numbering is 139-1～139-709.
Table 140, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCH2During C ≡ CI, Choose such as the compound of 1 identical substituent group of table, numbering is 140-1～140-709.
Table 141, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OSOCF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 141-1～141-709
Table 142, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OSOCF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 142-1～142-709
Table 143, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OSOCF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 143-1～143-709
Table 144, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OSOCF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 144-1～144-709
Table 145, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OSO2CF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 145-1～145-709
Table 146, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OSO2CF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 146-1～146-709
Table 147, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OSO2CF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 147-1～147-709
Table 148, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OSO2CF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 148-1～148-709
Table 149, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCO2CH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 149-1～149-709
Table 150, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCO2CH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 150-1～150-709
Table 151, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCO2CH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 151-1～151-709
Table 152, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCO2CH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 152-1～152-709
Table 153, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCONHCH3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 153-1～153-709
Table 154, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCONHCH3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 154-1～154-709
Table 155, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCONHCH3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 155-1～155-709
Table 156, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCONHCH3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 156-1～156-709
Table 157, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=SCF3When, choose such as With the compound of 1 identical substituent group of table, numbering is 157-1～157-709
Table 158, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=SCF3When, choose such as With the compound of 1 identical substituent group of table, numbering is 158-1～158-709
Table 159, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=SCF3When, choose such as With the compound of 1 identical substituent group of table, numbering is 159-1～159-709
Table 160, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=SCF3When, choose such as With the compound of 1 identical substituent group of table, numbering is 160-1～160-709
Table 161, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=SCF2During H, choose such as With the compound of 1 identical substituent group of table, numbering is 161-1～161-709
Table 162, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=SCF2During H, choose Such as the compound of 1 identical substituent group of table, numbering is 162-1～162-709
Table 163, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=SCF2During H, choose such as With the compound of 1 identical substituent group of table, numbering is 163-1～163-709
Table 164, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=SCF2During H, choose Such as the compound of 1 identical substituent group of table, numbering is 164-1～164-709
Table 165, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=SCH2During F, choose such as With the compound of 1 identical substituent group of table, numbering is 165-1～165-709
Table 166, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=SCH2During F, choose Such as the compound of 1 identical substituent group of table, numbering is 166-1～166-709
Table 167, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=SCH2During F, choose such as With the compound of 1 identical substituent group of table, numbering is 167-1～167-709
Table 168, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=SCH2During F, choose Such as the compound of 1 identical substituent group of table, numbering is 168-1～168-709
Table 169, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1During=SCHFCl, choose Such as the compound of 1 identical substituent group of table, numbering is 169-1～169-709
Table 170, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1During=SCHFCl, choose Such as the compound of 1 identical substituent group of table, numbering is 170-1～170-709
Table 171, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1During=SCHFCl, choose Such as the compound of 1 identical substituent group of table, numbering is 171-1～171-709
Table 172, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1During=SCHFCl, choose Such as the compound of 1 identical substituent group of table, numbering is 172-1～172-709
Table 173, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=SCCl2During H, choose Such as the compound of 1 identical substituent group of table, numbering is 173-1～173-709
Table 174, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=SCCl2During H, choose Such as the compound of 1 identical substituent group of table, numbering is 174-1～174-709
Table 175, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=SCCl2During H, choose Such as the compound of 1 identical substituent group of table, numbering is 175-1～175-709
Table 176, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=SCCl2During H, choose Such as the compound of 1 identical substituent group of table, numbering is 176-1～176-709
Table 177, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1During=OCHFCl, choose Such as the compound of 1 identical substituent group of table, numbering is 177-1～177-709
Table 178, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1During=OCHFCl, choose Such as the compound of 1 identical substituent group of table, numbering is 178-1～178-709
Table 179, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1During=OCHFCl, choose Such as the compound of 1 identical substituent group of table, numbering is 179-1～179-709
Table 180, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1During=OCHFCl, choose Such as the compound of 1 identical substituent group of table, numbering is 180-1～180-709
Table 181, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCCl2During H, choose Such as the compound of 1 identical substituent group of table, numbering is 181-1～181-709
Table 182, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCCl2During H, choose Such as the compound of 1 identical substituent group of table, numbering is 182-1～182-709
Table 183, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCCl2During H, choose Such as the compound of 1 identical substituent group of table, numbering is 183-1～183-709
Table 184, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCCl2During H, choose Such as the compound of 1 identical substituent group of table, numbering is 184-1～184-709
Table 185, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=SOCH3When, choose such as With the compound of 1 identical substituent group of table, numbering is 185-1～185-709
Table 186, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=SOCH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 186-1～186-709
Table 187, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=SOCH3When, choose such as With the compound of 1 identical substituent group of table, numbering is 187-1～187-709
Table 188, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=SOCH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 188-1～188-709
Table 189, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=SO2CH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 189-1～189-709
Table 190, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=SO2CH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 190-1～190-709
Table 191, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=SO2CH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 191-1～191-709
Table 192, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=SO2CH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 192-1～192-709
Table 193, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=SOCF3When, choose such as With the compound of 1 identical substituent group of table, numbering is 193-1～193-709
Table 194, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=SOCF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 194-1～194-709
Table 195, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=SOCF3When, choose such as With the compound of 1 identical substituent group of table, numbering is 195-1～195-709
Table 196, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=SOCF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 196-1～196-709
Table 197, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=SO2CF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 197-1～197-709
Table 198, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=SO2CF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 198-1～198-709
Table 199, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=SO2CF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 199-1～199-709
Table 200, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=SO2CF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 200-1～200-709
Table 201, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1= When, to choose such as the compound of 1 identical substituent group of table, numbering is 201-1～201-709
Table 202, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1= When, to choose such as the compound of 1 identical substituent group of table, numbering is 202-1～202-709
Table 203, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1= When, to choose such as the compound of 1 identical substituent group of table, numbering is 203-1～203-709
Table 204, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1= When, to choose such as the compound of 1 identical substituent group of table, numbering is 204-1～204-709
Table 205, A=O, B=O, X=H, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1= When, to choose such as the compound of 1 identical substituent group of table, numbering is 205-1～205-709
Table 206, A=O, B=O, X=H, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1= When, to choose such as the compound of 1 identical substituent group of table, numbering is 206-1～206-709
Table 207, A=O, B=O, X=H, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1= When, to choose such as the compound of 1 identical substituent group of table, numbering is 207-1～207-709
Table 208, A=O, B=O, X=H, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1= When, to choose such as the compound of 1 identical substituent group of table, numbering is 208-1～208-709
Table 209, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCH3When, choose such as With the compound of 1 identical substituent group of table, numbering is 209-1～209-709
Table 210, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 210-1～210-709
Table 211, A=O, B=O, X=Cl, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCH3When, choose such as With the compound of 1 identical substituent group of table, numbering is 211-1～211-709
Table 212, A=O, B=O, X=Cl, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 212-1～212-709
Table 213, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=SCH3When, choose such as With the compound of 1 identical substituent group of table, numbering is 213-1～213-709
Table 214, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=SCH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 214-1～214-709
Table 215, A=O, B=O, X=Cl, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=SCH3When, choose such as With the compound of 1 identical substituent group of table, numbering is 215-1～215-709
Table 216, A=O, B=O, X=Cl, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=SCH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 216-1～216-709
Table 217, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OSOCH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 217-1～217-709
Table 218, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OSOCH3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 218-1～218-709
Table 219, A=O, B=O, X=Cl, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OSOCH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 219-1～219-709
Table 220, A=O, B=O, X=Cl, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OSOCH3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 220-1～220-709
Table 221, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OSO2CH3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 221-1～221-709
Table 222, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OSO2CH3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 222-1～222-709
Table 223, A=O, B=O, X=Cl, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OSO2CH3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 223-1～223-709
Table 224, A=O, B=O, X=Cl, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OSO2CH3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 224-1～224-709
Table 225, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=SCF3When, choose such as With the compound of 1 identical substituent group of table, numbering is 225-1～225-709
Table 226, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=SCF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 226-1～226-709
Table 227, A=O, B=O, X=Cl, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=SCF3When, choose such as With the compound of 1 identical substituent group of table, numbering is 227-1～227-709
Table 228, A=O, B=O, X=Cl, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=SCF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 228-1～228-709
Table 229, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OSOCF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 229-1～229-709
Table 230, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OSOCF3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 230-1～230-709
Table 231, A=O, B=O, X=Cl, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OSOCF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 231-1～231-709
Table 232, A=O, B=O, X=Cl, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OSOCF3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 232-1～232-709
Table 233, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OSO2CF3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 233-1～233-709
Table 234, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OSO2CF3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 234-1～234-709
Table 235, A=O, B=O, X=Cl, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=OSO2CF3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 235-1～235-709
Table 236, A=O, B=O, X=Cl, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=OSO2CF3When, choosing Take such as the compound of 1 identical substituent group of table, numbering is 236-1～236-709
Table 237, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=SOCH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 237-1～237-709
Table 238, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=SOCH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 238-1～238-709
Table 239, A=O, B=O, X=Cl, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=SOCH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 239-1～239-709
Table 240, A=O, B=O, X=Cl, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=SOCH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 240-1～240-709
Table 241, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=SO2CH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 241-1～241-709
Table 242, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=SO2CH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 242-1～242-709
Table 243, A=O, B=O, X=Cl, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=SO2CH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 243-1～243-709
Table 244, A=O, B=O, X=Cl, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=SO2CH3When, choose Such as the compound of 1 identical substituent group of table, numbering is 244-1～244-709
Table 245, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=SOCF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 245-1～245-709
Table 246, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=SOCF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 246-1～246-709
Table 247, A=O, B=O, X=Cl, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=SOCF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 247-1～247-709
Table 248, A=O, B=O, X=Cl, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=SOCF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 248-1～248-709
Table 249, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=Cl, R7=H, R9=H, YR1=SO2CF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 249-1～249-709
Table 250, A=O, B=O, X=Cl, Z=N, R2=Cl, R3=CH3,R7=H, R9=H, YR1=SO2CF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 250-1～250-709
Table 251, A=O, B=O, X=Cl, Z=N, R2=CN, R3=Cl, R7=H, R9=H, YR1=SO2CF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 251-1～251-709
Table 252, A=O, B=O, X=Cl, Z=N, R2=CN, R3=CH3,R7=H, R9=H, YR1=SO2CF3When, choose Such as the compound of 1 identical substituent group of table, numbering is 252-1～252-709
Table 253, A=O, B=O, X=H, R2=Cl, R3=Cl, R7=H, R9=H, YR1=OCH3When, choose following chemical combination Thing, numbering are 253-1～253-980.
Table 254, A=O, B=O, X=H, R2=Cl, R3=CH3,R7=H, R9=H, YR1=OCH3When, choose such as table The compound of 253 identical substituent groups, numbering is 254-1～254-980.
Table 255, A=O, B=O, X=H, R2=CN, R3=Cl, R7=H, R9=H, YR1=OCH3When, choose such as table The compound of 253 identical substituent groups, numbering is 255-1～255-980.
Table 256, A=O, B=O, X=H, R2=CN, R3=CH3,R7=H, R9=H, YR1=OCH3When, choose such as table The compound of 253 identical substituent groups, numbering is 256-1～256-980.
Table 257, A=O, B=O, X=H, R2=Cl, R3=Cl, R7=H, R9=H, YR1=SCH3When, choose such as table The compound of 253 identical substituent groups, numbering is 257-1～257-980.
Table 258, A=O, B=O, X=H, R2=Cl, R3=CH3,R7=H, R9=H, YR1=SCH3When, choose such as table The compound of 253 identical substituent groups, numbering is 258-1～258-980.
Table 259, A=O, B=O, X=H, R2=CN, R3=Cl, R7=H, R9=H, YR1=SCH3When, choose such as table The compound of 253 identical substituent groups, numbering is 259-1～259-980.
Table 260, A=O, B=O, X=H, R2=CN, R3=CH3,R7=H, R9=H, YR1=SCH3When, choose such as table The compound of 253 identical substituent groups, numbering is 260-1～260-980.
The compound of Formula I of the present invention can be prepared in accordance with the following methods：
Method one：
Compound of Formula I can be by the oxazine ketone compounds and R shown in formula II9Lg (Lg is leaving group, such as halogen, Alkyl or aryl sulphonic acid ester or alkyl sulfate) reaction be obtained intermediate II ', then with HNR7R8Reaction is obtained：
Method two：
Compound of Formula I can be by the oxazine ketone compounds and HNR shown in formula II7R8Reaction is obtained intermediate compound I ', then with R9Lg (Lg is leaving group, such as halogen, alkyl or aryl sulphonic acid ester or alkyl sulfate) reactions are obtained：
Method three：
Compound of Formula I can be by shown in general formula III compound and (Cl3CO)2The prepared intermediate compound IV of CO reactions, then with R9Lg (Lg is leaving group, such as halogen, alkyl or aryl sulphonic acid ester or alkyl sulfate) reactions are obtained intermediate V, then with HNR7R8Reaction is obtained intermediate VI, is finally obtained with pyrazole acyl chloride reaction.Wherein pyrazole acyl chloride can be by corresponding carboxylic acid by normal The method of rule is obtained, and such as reacts with thionyl chloride：
In formula, each group is as defined above.
Reaction is carried out in a solvent, suitable selected from such as acetonitrile, tetrahydrofuran, ether, dichloromethane, chloroform, acetic acid second Ester, dioxane, toluene etc..
Reaction temperature in room temperature between solvent boiling point temperature, usually 20～100 DEG C.
Response time is 30 minutes to 20 hours, usually 1～10 hour.
In above-mentioned preparation method, involved raw material midbody and source are as follows：
Oxazine ketone compounds shown in formula II, Reviews are shown in Biorganic and Medicinal Chemistry 2008,8,2095-2103 and J.Heterocyclic Chemistry 1999,36,563-588.Its preparation side Method is with reference to WO03015519, WO2005118552 method.
Anthranilic acid compound shown in general formula III, can be obtained by aromatic hydrocarbons Jing two-step reactions, and reference literature is such as Under：Organic Synthesis,Coll.Vol.10.p.23(2004)；Vol.79,p.196(2002)； Adv.Heterocycl.Chem.1975,18,1-58；Journal of the Brazilian Chemical Society 2001,12(3),273-324；Angew.Chem.Int.Ed.Engl.1980,19,222-223.
The preparation method of the carboxylic acid compound shown in formula VII is with reference to WO2006062978, WO03015519.
The compound of Formula I of the present invention to the adult of agriculture, civilian and zoo technical field harmful insect, larva and ovum all Show high insecticidal activity.Part of compounds shows preferable bactericidal activity.Therefore, the present invention also includes formula I chemical combination Application of the thing in agricultural and other fields as insecticide and/or antibacterial.
Especially, compound of Formula I is active to following section and the important kind of purpose：Lepidoptera (Beet armyworm category, real noctuid Category, straw borer spp, codling moth etc.).For example to European corn borer, sugarcane borer, codling moth, codling moth, Gypsymoth etc. is largely effective, particularly to diamondback moth activity more preferably, good effect is obtained with very low dosage.Together When, the part of compounds of the present invention shows preferable bactericidal activity, can be used to prevent and treat rice blast, cucumber downy mildew, charcoal Cellulitis disease.
Meanwhile, compound of Formula I has hypotoxicity to many beneficial insecticides and acarid, mammal, fish, bird, and Without phytotoxicity.
Due to its positive characteristic, above-claimed cpd is advantageously used for the important crop of protecting agriculture and horticulture, family Poultry and breeding stock, and the environment that often goes of the mankind avoids the injury of harmful insect and funguses.
To obtain ideal effect, the consumption of compound changes because of various factors, such as compound used therefor, the work of pre- protection Thing, the species of harmful organism, gradient of infection, weather conditions, application method, the dosage form for adopting.
The compound dosage of 10 grams -5 kilograms of per hectare can provide sufficiently preventing and treating.
Another object of the present invention is further related to by applying compound of Formula I, preventing and treating agricultural and the important crop of horticulture And/or the method for the insecticide in the environment that often goes of domestic animal and breeding stock and/or the mankind and/or plant pathogenic fungi.Especially, change The consumption of compound changes in 10 grams -5 kilograms of per hectare.
In order to be applied to agricultural, it is typically beneficial using the compositionss containing one or more compound of Formula I.
Therefore, another object of the present invention design containing one or more compound of Formula I as active component parasite killing and/ Or bactericidal composition.
The type of service of compositionss can be dry powder, wettable powder, cream, microemulsion, paste, granule, solution, outstanding Floating agent etc.：Types of compositions selected from depending on specific application.
Compositionss are prepared in a known manner, such as in the presence of optional surfactant, by solvent medium and/ Or solid diluent or dissolving active substance.
Available solid diluent or carrier are for example：Silicon dioxide, Kaolin, bentonite, Talcum, kieselguhr, white clouds Stone, Calcium Carbonate, magnesium oxide, Chalk, clay, synthetic silicate Attagel, meerschaum etc..
Than water, available liquid diluent also includes aromatic organic solvent (mixture of dimethylbenzene or alkylbenzene, chlorine Benzene etc.), paraffin (petroleum distillate), alcohols (methanol, propanol, butanol, capryl alcohol, glycerol), esters (ethyl acetate, isobutyl acetate Deng), ketone (Ketohexamethylene, acetone, 1-Phenylethanone., isophorone, ethyl pentyl group ketone etc.), amide-type (DMF, N- Methyl pyrrolidone etc.).
Available surfactant be alkylsulfonate, alkylaryl sulfonatess, polyoxyethanyl alkyl phenol, Sorbitol it is poly- The sodium of oxygen vinyl acetate, lignosulfonates etc., calcium, triethyl group or triethanolamine salt.
Compositionss can also contain special additive for specific purpose, such as containing binding agent such as arabic gum, poly- second Enol, polyvinylpyrrolidone etc..
In above-mentioned composition, the concentration of active component can be according to the system of active component, application target, environmental condition and employing Agent type and change in a wide range.Generally, the concentration of active component is 1%-90%, preferred 5%-60%.
It is possible if desired to in compositionss addition can be compatible with compound of Formula I other active component, for example other Acaricide/insecticide, antifungal, plant growth regulator, antibiotic, herbicide, fertilizer.
The compound method of several dosage forms is exemplified below：
The preparation of suspending agent：In common prescription, active component content is 5%-35%.With water as medium, by active compound, dispersion During agent, suspending agent and antifreeze etc. add sand mill, it is ground, makes suspending agent.
The preparation of aqueous emulsion：Active compound, solvent and emulsifying agent are added together, make to be dissolved into homogeneous oil phase.By water, antifreeze Etc. being mixed, become homogeneous water phase.Under high velocity agitation, water is added to into oil phase or oil phase is added to water phase, formed and divided The good aqueous emulsion of scattered property.The aqueous emulsion active component content of the present invention is generally 5%-15%.To prepare emulsifiable concentrate, the present invention Compound be dissolvable in water one or several mixed solvents, add emulsifying agent to strengthen dispersion effect of the compound in water.
The preparation of wettable powder：It is by recipe requirements, active compound, various surfactants and solid diluent etc. is fully mixed Close, Jing after ultra-fine pulverizer disintegrating, that is, obtain the wettable powder product of predetermined content (such as 10%-40%).It is suitable to prepare In the wettable powder of sprinkling, the compound of the present invention can be with finely ground pressed powder such as clay, electrodeless silicate, carbonic acid Salt and wetting agent, binding agent and/or dispersant composition mixture.
The preparation of water-dispersible granules：Active compound and powdered solid diluents, moistening spreader-sticker and binding agent etc. are mixed Close and crush, after adding water kneading, in adding the granulating agent equipped with certain specification screen cloth, carry out pelletize, then drying, screening again (pressing screen cloth scope).Also active compound, dispersant, disintegrating agent and wetting agent and solid diluent can be added in sand mill, with water is Medium milling, makes suspending agent, then carries out spray drying granulation, is typically formulated content for 20%-30% granular products.
Specific embodiment
Example is used for further illustrating the present invention in detail below, but the present invention is limited to absolutely not these examples.
Synthetic example
Embodiment 1：The preparation of compound 1-1
Under room temperature, II-1 (1.0mmol, 0.503g), 5 milliliters of N, N- dimethyl formyls are added in 25 milliliters of reaction bulbs Amine, the lower ammonia for adding 0.136 gram 25% of stirring, room temperature reaction.TLC is monitored after completion of the reaction, and reactant liquor is added drop-wise to 30 millis Rise in water, separate out solid, sucking filtration, washing are dried, obtain product 0.284g, i.e. compound 1-1, yield 55%.
Embodiment 2：The preparation of compound 1-7
Under room temperature, II-1 (1.0mmol, 0.503g), 5 milliliters of N, N- dimethyl formyls are added in 25 milliliters of reaction bulbs Amine, ClCH2CH2NH2HCl (3.0mmol, 0.348g), stirring is lower to add NaH (3.0mmol, 0.072g), room temperature reaction.TLC Monitoring after completion of the reaction, reactant liquor is added drop-wise in 30 milliliters of water, separates out solid, and sucking filtration, washing are dried, obtain product 0.325g, That is compound 1-7, yield 56%.
Embodiment 3：The preparation of compound 1-10
Under room temperature, II-1 (1.0mmol, 0.503g), 5 milliliters of N, N- dimethyl formyls are added in 25 milliliters of reaction bulbs Amine, stirring is lower to add (CH3)2CHNH2(2.0mmol, 0.118g), room temperature reaction.TLC is monitored after completion of the reaction, will react drop It is added in 30 milliliters of water, separates out solid, sucking filtration, washing is dried, obtains product 0.336g, i.e. compound 1-10, yield 60%.
Other compounds of formula I can use the logical preparation method for providing of the present invention to be obtained.
Fusing point and mass spectrum (ESI) data of partial Formula I are as follows：
Compound 1-1：144-146 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):517.9/519.9/521.9
Compound 1-2：223-225 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):532.0/534.0/536.0
Compound 1-3：205-207 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):545.9/547.9/549.9
Compound 1-7：109-111 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):579.8/581.8/583.8
Compound 1-8：117-119 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):625.9/627.9/629.9
Compound 1-10：178-180 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):559.8/561.8/563.8
Compound 1-12：108-110 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):555.9/557.9/559.9
Compound 1-15：159-161 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):573.8/575.8/577.8
Compound 1-19：87-89 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):575.9/577.9/579.9
Compound 1-21：107-109 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):572.0/574.0/576.0
Compound 1-32：117-119 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):587.9/589.9/591.9
Compound 1-33：126-128 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):601.8/603.8/605.8
Compound 1-35：139-141 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):575.9/577.9/579.9
Compound 1-36：128-130 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):603.0/605.0/607.0
Compound 1-41：145-147 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):602.9/604.9/606.9
Compound 1-42：126-128 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):584.0/586.0/588.0
Compound 1-43：164-166 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):615.9/617.9/619.9
Compound 1-45：205-207 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):630.9/632.9/634.9
Compound 1-56：105-107 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):619.9/621.9/623.9
Compound 16-2：259-261 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):621.8/623.8/625.8
Compound 16-10：165-167 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):649.9/651.9/653.9
Compound 16-32：118-120 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):677.8/679.8/681.8
Compound 16-33：124-126 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):691.9/693.9/695.9
Compound 16-36：116-118 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):692.8/694.8/696.8
Compound 16-37：249-251 DEG C of fusing point；Mass spectrum ESI (m/z, M+H+):691.9/693.9/695.9
Example of formulations (each component addition is weight percentage, and reactive compound folding hundred is post-dised)
Embodiment 4:30% wettable powder
Compound 1-152, various surfactants and solid diluent etc. are sufficiently mixed, Jing ultra-fine pulverizer disintegratings Afterwards, and obtain 30% wettable powder product
Embodiment 5:20% suspending agent
With water as medium, compound 1-218, dispersant, suspending agent and antifreeze etc. are added in sand mill, is ground Mill, makes suspending agent.
Embodiment 6:60% water-dispersible granules
Compound 1-220 and powdered solid diluents, moistening spreader-sticker and binding agent etc. are carried out into co-grinding, is added water After kneading, pelletize is carried out in the comminutor for adding 10-100 eye mesh screens, then drying again, screening (presses screen cloth scope).
Embodiment 7:10% aqueous emulsion
Compound 1-264, solvent and emulsifying agent are added together, make to be dissolved into homogeneous oil phase.Water, antifreeze etc. are mixed Together, become homogeneous water phase.Under high velocity agitation, water phase and oil phase are mixed, forms the aqueous emulsion of favorable dispersibility.
Embodiment 8:25% suspending agent
With water as medium, compound 1-257, dispersant, suspending agent and antifreeze etc. are added and are ground in sand mill, Make suspending agent.
Embodiment 9:20% wettable powder
Compound 1-271, various surfactants and solid diluent etc. are sufficiently mixed, Jing ultra-fine pulverizer disintegratings Afterwards, that is, obtain 20% wettable powder product.
Biological activity determination embodiment
10 pesticide and miticide actility of example is determined
The compounds of this invention can prevent and treat following insect：
Lepidoptera (moth and butterfly)：It is diamond-back moth, beet armyworm (Radix Betae armyworm), rice leaf roller, South America maize seedling phycitid, brown Argyrotaenia spp category kind, Fructus Litchi litchi, earias fabia, adoxophyes moth, earias insulana, tiger category kind (cutworm), rice Cnaphalocrocis spp (meadow leaf roller), little Stachys geobombycis C. Y. Wu (black cutworm), Earias kind (bollworm), Chlumetia transversa Walker, west Southern corn stalk crambid, cotton leaf ripple noctuid (cotton leafworm), oriental fruit months (east heart-eating worm), little sugarcane borer, cotton sliver gelechiid, Semen Glycines powder Butterfly category kind, high Corchorus olitorius L. bridge night, snout moth's larva category kind (stem borer), the wooden stupid moth (wooden stupid moth) of fragrance, Anticarsia, Diaphania kind (moth stem Worm), fruittree leafroller, Fructus Mali pumilae stupid moth (codling moth), Flos Rosae Multiflorae leaf roller, high Semen Pisi sativi moth pod, Kattapillar category kind (noctuid), bag moth (bagworm), roll up moth category kind, soybean pod open country snout moth's larva (bean open country snout moth's larva), Fructus Citri tangerinae Argyrotaenia spp (citrus leaf-roller), lopper worm (dish march moth), cotton Leaf lyonetid, Agrotis kind (cutworm), tobacco budworm, shallow brown apple moth, Lee's Grapholita spp (Li Guoe), Malacosoma Plant, thin moth category plants (leaf miner), Heliothis kind (noctuid), former cutworm, straw borer spp kind, peach fruit moth (peach fruit moth), oil The white wing open country snout moth's larva of Petiolus Trachycarpi bag moth, eggplant, paddy reality noctuid (Pyrausta nubilalis (Hubern). ridge (snout moth's larva ridge worm/bollworm)), bollworm, Flos Rosae Rugosae Choristoneura spp, bean are white The stupid moth of line cutworm, Fructus Lycopersici esculenti, thin moth category kind, the brown volume moth of boundary (common glucose leaf roller), east moth fruit moth (the sub- food heart of Fructus Persicae (Fructus Pruni) Worm), the green noctuid of first mat, little Fructus Lycopersici esculenti moth, European corn borer (European corn borer), treble cut snout moth (bean pyralid), Hellula undalis, Thin moth category kind (leaf miner), Noctua kind, Indarbela category kind (root moth), boundary Noctua kind (cutworm), 3 points of water snout moth's larvas (rice leaf roller), Sesamia inferens, winter looper, India paddy speckle moth, Pectinophora gossypiella (pink bollworm), variegated cutworm, Fructus Vitis viniferae are little Leaf roller, grape berry moth, African Bodhidharma Papilio xuthus (Linne)．, gypsymoth, meal moth category kind (a powder snout moth's larva), Mediterranean flour moth, coffee leafminer, Apple leaf miner (Fructus Mali pumilae leaf miner), cabbage looper, gelechiid, armyworm, phthorimaea operculella, yellow rice borer, powder stem snout moth's larva, emerging Noctua Kind of (root moth), Semen sojae atricolor noctuid, ligustrum fine tortricidae (grape berry moth), Spodoptera kind (armyworm), pilleriana, The stupid moth of pears leopard, Fructus Citri tangerinae fruit ermine moth, Spodopterafrugiperda (autumn armyworm), Fructus oleae europaeae ermine moth, cabbage butterfly (external Pieris rapae), Loxagrotis category kind (noctuid), apple brown bortrix, pear leaf blister moth, Crambus Fabricius kind, mandarin orange leaf lyonetid, casemaking clothes moth, mythimna separata category kind (night Moth), Yponomeuta kind, southern spodoptera (southern armyworm), Erionota thorax (Linne)., meal moth, moth stem night high category kind (stem borer), cigarette Grass meal phycitid (Nicotiana tabacum L. snout moth's larva), the stupid moth of coffee leopard, Epimeces category kind, angle sword Noctua kind (stem borer), night steinernema, looper, The brown Limacodidae of Liriomyza brponiae, copper stain.
Homoptera (aleyrodid, aphid, leafhopper, a red-spotted lizard)：Aphid a red-spotted lizard category kind (aphid), rhopalosiphum padi, green bugs (wheat y-bend Aphid), Semen Maydiss tree louse (corn leaf aphids), sound Aphis kind (aphid), Trialeurodes vaporariorum Westwood (greenhouse whitefly), olive pearl lecanium (black a red-spotted lizard), arrow point Clam (arrow a red-spotted lizard), grain aphid (Britain's wheat aphid), variegation Aphis kind (aphid), knot wing trialeurodes vaporariorum, pearl lecanium category kind (a red-spotted lizard), white lead Pediculus kind (aleyrodid), white backed planthopper, sharp armored scale category kind (a red-spotted lizard), stricture of vagina lecanium category kind (a red-spotted lizard), rice green leafhopper (greenery Cicadae), ebony shield A red-spotted lizard, theatre armored scale (san jose scale), four line leafhopper (Aster tataricus leafhopper), froghopper category kind (spittle insects), Acyrthosiphon dirhodum (Flos Rosae Multiflorae wheat Aphid), mealybug category kind of (mealybug), black peach aphid (black peach aphid), the clean mealybug of Fructus Ananadis comosi, rice green leafhopper category kind (leafhopper), a buttockss stricture of vagina mealybug category kind (powder A red-spotted lizard), brown paddy plant hopper, Physokermes piceae, bran piece armored scale, grape phylloxera, popcorn wing plant hopper, acyrthosiphum pisim, Aspidiotus category kind of (a red-spotted lizard), ash Plant hopper, blow cotton a red-spotted lizard, asparaguss tubule aphid (asparaguss aphid), adelgid category kind, rose aphid (Flos Rosae Multiflorae aphid), the pink bad aphid of Herba Marsileae Quadrifoliae, sweet Blue powder louse (Brassica oleracea L.var.capitata L. aleyrodid), grain aphid (Britain's wheat aphid), white wheel armored scale category kind, long tube Aphis kind, cotten aphid, lepidosaphes shimer Kind, Diuraphis noxia (Russian aphid), lecanium category kind of (a red-spotted lizard), Aleurodicus dispersus, Aleyrodes kind (aleyrodid), brevicoryne brassicae (Brassica oleracea L.var.capitata L. aphid), It is Radix Euphorbiae Pekinensis Macrosiphus spp (potato aphid), velvet aleyrodid (whitefly in bt cotton), Fructus Mangifera Indicae yellow line leafhopper, froghopper category kind of (leafhopper), apple aphid, red Circle a red-spotted lizard (the red a red-spotted lizard in California), green jassids category kind (leafhopper), ceroplastes rubens, sweet potato whitefly, snow armored scale category kind (a red-spotted lizard), Aphis (aphid), Bemisia argentifolii, apple aphid, soft wax a red-spotted lizard category kind (a red-spotted lizard), eggplant are planted without net aphid (digitaliss aphid).
Insecticidal activity assay test has been carried out to several insecticides and demodicid mite with the compounds of this invention.Method for measuring is as follows：
After testing compound is with DMF dissolving, needed for being diluted to the water containing 0.1% Tween 80 Concentration.
With diamondback moth, beet armyworm as target, carried out using airbrush nebulizations and immersion method (culex pipiens pallens larvae) Pesticidal measure, the pressure of airbrush spraying treatments (are roughly equal to 0.7kg/cm for 10pis2), spouting liquid is 0.5 milliliter.Process The mortality rate of target is investigated 2-3 days afterwards.
Partial test result is as follows：
Liquor strength be 100ppm when, compound 1-1,1-2,1-3,1-10,1-12,1-15,1-32,1-33,1-35, 16-2 is to diamondback moth mortality rate up to 100%；Compound 1-1,1-2,1-3,1-10,1-12,1-15,1-32,1-33,1-35,16- 2 pairs of beet armyworm mortality rates are up to 100%.
When liquor strength is 20ppm, compound 1-1,1-2,1-3,1-10,1-12,1-15,1-32,1-33,1-35,16- 2 pairs of diamondback moth mortality rates are up to 100%；Compound 1-1,1-2,1-3,1-10,1-12,1-15,1-32,1-33,16-2 are to Radix Betae Noctuid mortality rate is up to 100%.
When liquor strength is 4ppm, compound 1-1,1-2,1-3,1-10,1-12,1-15,1-32,1-33,16-2 are to little Diamond-back moth mortality rate is up to 100%；Compound 1-1,1-2,1-3,1-10,1-15,1-32,16-2 are reached to beet armyworm mortality rate 100%.
When liquor strength is 2ppm, compound 1-1,1-2,1-3,1-10 are to diamondback moth mortality rate up to 100%；Compound 1- 2nd, 1-10,1-15,1-32,16-2 to beet armyworm mortality rate up to 100%.
When liquor strength is 1ppm, compound 1-1,1-2,1-3 are to diamondback moth mortality rate up to 100%；Compound 1-2,1- 10 pairs of beet armyworm mortality rates are up to 100%.
When liquor strength is 0.5ppm, compound 1-2,1-3 are to diamondback moth mortality rate up to 100%；Compound 1-2,1-10 To beet armyworm mortality rate up to 100%.
With aphid as target, insecticidal activity assay is carried out using Potter spray towers nebulization, 2-3 days investigate target after process Target mortality rate.
Partial test result is as follows：
When liquor strength is 100ppm, compound 1-1,1-2,1-3,1-10 are to aphid mortality rate up to 100%.
When liquor strength is 20ppm, compound 1-1,1-2,1-3,1-10 are to aphid mortality rate up to 100%.
When liquor strength is 4ppm, compound 1-2,1-10 are to aphid mortality rate up to more than 90%.
According to above method, choosing compound 1-2,1-10 and known compound Rynaxypyr carries out killing aphids activity Parallel assay.Experimental result see the table below：
Killing aphids determination of activity table：
Compound number Concentration (ppm) Mortality rate (%)
1-2 4 95.81
1-10 4 90.96
Rynaxypyr 4 53.17

Claims (10)

1. a kind of substituted salicylamide class compound, as shown in formula I：
In formula：
A, B may be the same or different, and be respectively and independently selected from O, S or NRa；Ra=H, CN, NO2、NH2、NHCH3、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl；
X is selected from H, halogen, CN, NO2、NH2, CHO, CH=NOCH3, CH=NNHCH3, CH=NN (CH3)2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl；
Y is selected from O, S, S (=O), S (=NRb), S (=O)n(=NRb)2-n(n=1 or 2；Rb=H, CN, NO2) or NRc；Rc=H, CN、NO2、NH2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkylamino radical, halo C1-C6Alkylamino radical, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2- C6Alkynyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6 Alkylaminocarbonyl, halo C1-C6Alkylaminocarbonyl, C1-C6Alkylamino radical thiocarbonyl, halo C1-C6Alkylamino radical thiocarbonyl, C1-C6 Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkane Epoxide carbonyl C1-C6Alkyl, C1-C6Alkylaminocarbonyl C1-C6Alkyl, halo C1-C6Alkylaminocarbonyl C1-C6Alkyl, replacement or not Substituted aryl carbonyl, substituted or unsubstituted aryloxycarbonyl, substituted or unsubstituted Heteroarylcarbonyl, replacement or unsubstituted Heteroaryloxycarbonyl, substituted or unsubstituted aryl amine carbonyl, substituted or unsubstituted aryl amine thiocarbonyl, C1-C6Alkane is sub- Sulfonyl, halo C1-C6Alkyl sulfinyl, C1-C6Alcoxyl sulfinyl, halo C1-C6Alcoxyl sulfinyl, C1-C6Alkane sulphonyl Base, halo C1-C6Alkane sulfonyl, C1-C6Alcoxyl sulfonyl, halo C1-C6Alcoxyl sulfonyl；
Z is selected from N or CRd；Rd=H, halogen or NO2；
R1Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halo C2- C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alcoxyl Asia sulphur Acyl group, halo C1-C6Alcoxyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alcoxyl sulfonyl, halo C1-C6Alcoxyl sulfonyl, amino C1-C6Alkyl, amino halogen C1-C6Alkyl, hydroxyl C1-C6Alkyl, hydroxy halogeno C1-C6Alkyl, Sulfydryl C1-C6Alkyl, sulfydryl halo C1-C6Alkyl, cyano group C1-C6Alkyl, cyano halo C1-C6Alkyl, C1-C6Alkoxy C1-C6 Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Halogenated alkoxy C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, halo C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkylthio group halo C1-C6Alkyl, C1-C6Alkylamino radical C1-C6Alkyl, halo C1-C6Alkylamino radical C1-C6Alkyl, C1-C6Alkylamino radical halo C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxyl carbonyl Base, halo C1-C6Alkoxy carbonyl, C1-C6Alkylthiocarbonyl, halo C1-C6Alkylthiocarbonyl, C1-C6Alkylaminocarbonyl, halo C1-C6Alkylaminocarbonyl, C1-C6Alkylamino radical thiocarbonyl, halo C1-C6Alkylamino radical thiocarbonyl, C1-C6Alkyl-carbonyl C1-C6Alkane Base, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkane Base, C1-C6Alkylaminocarbonyl C1-C6Alkyl, halo C1-C6Alkylaminocarbonyl C1-C6Alkyl, C1-C6Alkylthiocarbonyl C1-C6Alkane Base, halo C1-C6Alkylthiocarbonyl C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkyl, substituted or unsubstituted aryl Halo C1-C6Alkyl, substituted or unsubstituted aryloxy group C1-C6Alkyl, substituted or unsubstituted aryloxy group halo C1-C6Alkyl, Substituted or unsubstituted aryl amine C1-C6Alkyl, substituted or unsubstituted aryl amine halo C1-C6It is alkyl, substituted or unsubstituted Heteroaryl C1-C6Alkyl, substituted or unsubstituted heteroaryl halo C1-C6Alkyl, substituted or unsubstituted heteroaryloxy C1-C6Alkane Base, substituted or unsubstituted heteroaryloxy halo C1-C6Alkyl, substituted or unsubstituted heteroaryl amido C1-C6Alkyl, replacement or Unsubstituted heteroaryl amido halo C1-C6Alkyl, substituted or unsubstituted aryl carbonyl C1-C6Alkyl, substituted or unsubstituted virtue Base carbonyl halides are for C1-C6Alkyl, substituted or unsubstituted aryloxycarbonyl C1-C6Alkyl, substituted or unsubstituted aryloxycarbonyl Halo C1-C6Alkyl, substituted or unsubstituted aryl amine carbonyl C1-C6Alkyl, substituted or unsubstituted aryl amine carbonyl halides are for C1- C6Alkyl, substituted or unsubstituted Heteroarylcarbonyl C1-C6Alkyl, substituted or unsubstituted Heteroarylcarbonyl halo C1-C6Alkyl, Substituted or unsubstituted Heteroaryloxycarbonyl C1-C6Alkyl, substituted or unsubstituted Heteroaryloxycarbonyl halo C1-C6Alkyl, take Generation or unsubstituted heteroaryl amino-carbonyl C1-C6Alkyl, substituted or unsubstituted heteroaryl amino-carbonyl halo C1-C6Alkyl, replacement Or unsubstituted aryl carbonyl, substituted or unsubstituted aryloxycarbonyl, substituted or unsubstituted aryl amine carbonyl, replace or Unsubstituted aryl amine thiocarbonyl, substituted or unsubstituted Heteroarylcarbonyl, substituted or unsubstituted Heteroaryloxycarbonyl, take Generation or unsubstituted heteroaryl amino-carbonyl, substituted or unsubstituted heteroaryl amido thiocarbonyl；
R2,R3May be the same or different, be respectively selected from H, halogen, CN, NO2、NH2、CONH2、C1-C6Alkyl, halo C1-C6Alkyl, C2- C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkane Epoxide, halo C1-C6Alkoxyl, C1-C6Alkyl amine group, halo C1-C6Alkyl amine group, C1-C6Alkylthio group, halo C1-C6Alkane sulfur Base, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl Carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkylaminocarbonyl, halo C1-C6Alkylaminocarbonyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkane Base, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkoxyl, halo C1-C6Alkyl-carbonyl C1-C6Alcoxyl Base, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alcoxyl Base, halo C1-C6Alkoxy carbonyl C1-C6It is alkoxyl, unsubstituted or by the amino C of following substituent group1-C6Alkyl, aryl, Aryloxy group, aryl C1-C6Alkyl, aryl C1-C6Alkoxyl, heteroaryl, heteroaryl C1-C6Alkyl, heteroaryl C1-C6Alkoxyl：Halogen Element, cyano group, nitro, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkylthio group or C1- C6Alkyl-carbonyl；
R4Selected from H, halogen, CN, CONH2、CSNH2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkanes Base, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C2-C6Alkenyloxy group, halo C2-C6Alkenyloxy group, C2-C6Alkynyloxy group, halo C2-C6Alkynyloxy group, cyano group C1-C6Alkyl, cyano halo C1- C6Alkyl, cyano group C1-C6Alkoxyl, cyano halo C1-C6Alkoxyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxyl C1-C6Alkyl, C1-C6Alkyl sulfinyl epoxide, halo C1-C6Alkyl sulfinyl epoxide, C1-C6Alkyl sulfinyl amido, halo C1-C6Alkyl sulfinyl amido, C1-C6Alkyl sulfinyl epoxide C1-C6Alkyl, halo C1-C6Alkyl sulfinyl epoxide C1-C6Alkane Base, C1-C6Alkyl sulfinyl amido C1-C6Alkyl, halo C1-C6Alkyl sulfinyl amido C1-C6Alkyl, C1-C6Alkane sulfonyl oxygen Base, halo C1-C6Alkane sulfonyl epoxide, C1-C6Alkane sulfonyl amido, halo C1-C6Alkane sulfonyl amido, C1-C6Alkane sulfonyl oxygen Base C1-C6Alkyl, halo C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, C1-C6Alkane sulfonyl amido C1-C6Alkyl, halo C1-C6Alkane Sulfonyl amido C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkane Epoxide carbonyl, C1-C6Alkylaminocarbonyl, halo C1-C6Alkylaminocarbonyl, C1-C6Alkoxy carbonyl C1-C6Alkoxyl, halo C1- C6Alkoxy carbonyl C1-C6Alkoxyl, C1-C6Alkylaminocarbonyl C1-C6Alkoxyl, halo C1-C6Alkylaminocarbonyl C1-C6Alcoxyl Base, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkylaminocarbonyl C1-C6Alkane Base, halo C1-C6Alkylaminocarbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkane Base, C1-C6Alkyl-carbonyl C1-C6Alkoxyl, halo C1-C6Alkyl-carbonyl C1-C6Alkoxyl, substituted or unsubstituted aryl C1-C6 Alkyl, substituted or unsubstituted aryl halide are for C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkoxyl, replacement do not take The aryl halide in generation is for C1-C6Alkoxyl, substituted or unsubstituted heteroaryl C1-C6Alkyl, substituted or unsubstituted heteroaryl halo C1-C6Alkyl, substituted or unsubstituted heteroaryl C1-C6Alkoxyl, substituted or unsubstituted heteroaryl halo C1-C6Alkoxyl；
R5,R6May be the same or different, be respectively selected from H, halogen, CN, NO2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, Halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkylthio group, halo C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6 Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkyl amino, C2-C6Dialkyl amido, C3-C8Cycloalkyl amino, C1-C6Alkyl amino-carbonyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkoxy C1-C6Alkoxyl, halo C1-C6Alcoxyl Base C1-C6Alkoxyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkoxyl carbonyl Base C1-C6Alkoxyl, halo C1-C6Alkoxy carbonyl C1-C6Alkoxyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl Carbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkoxyl, halo C1-C6Alkyl-carbonyl C1-C6Alkoxyl；
R7Selected from H；C1-C6Alkyl, C3-C8Cycloalkyl, C2-C6Thiazolinyl, C2-C6Alkynyl, each of which is optionally by one or more Following substituent group replaces：Halogen, CN, NO2、OH、C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxyl, halo C1-C6Alkane Epoxide, C1-C6Alkylthio group, halo C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulphonyl Base, halo C1-C6Alkane sulfonyl, C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, phenyl, phenoxy group, 5 yuan of hetero-aromatic rings and 6 yuan are miscellaneous Aromatic ring；Phenyl, phenoxy group, 5 yuan of hetero-aromatic rings and 6 yuan of hetero-aromatic rings are each optionally independent selected from following substituent group by 1 to 3 Replace：C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, halogen, CN, NO2、C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkylthio group, C1- C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl amino, C2-C6Dialkyl amido, C3-C8Cycloalkyl amino, C1-C6(alkyl) (cycloalkyl) amino, C1-C6Alkyl-carbonyl, C1-C6Alcoxyl Base carbonyl, C1-C6Alkyl amino-carbonyl, C2-C8Dialkyl amino carbonyl；C1-C6Alkoxyl；C1-C6Alkyl amino；C2-C6Dioxane Base amino；C3-C8Cycloalkyl amino；C1-C6Alkyl-carbonyl or C1-C6Alkoxy carbonyl；
R8Selected from H, OH, NH2、C(CH3)2CH2S(O)(NH)CH3、C(CH3)2CH2S(O)(NCN)CH3、C1-C6Alkyl, halo C1- C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynes Base, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C3-C8 Cycloalkyl C1-C6Alkyl, halo C3-C8Cycloalkyl C1-C6Alkyl, C3-C8Oxacycloalkyl, C3-C8Oxacycloalkyl C1-C6Alkane Base, hydroxyl C1-C6Alkyl, C1-C6Alkyl amine group C1-C6Alkyl, two (C1-C6Alkyl) amido C1-C6Alkyl, replacement or unsubstituted Pyridine radicals C1-C6Alkyl, substituted or unsubstituted thiazolyl C1-C6Alkyl, substituted or unsubstituted pyridyloxy C1-C6Alkane Base, substituted or unsubstituted pyridine thio C1-C6Alkyl, substituted or unsubstituted pyridine amido C1-C6Alkyl, replacement do not take The morpholine base in generation, replace or or unsubstituted piperazinyl, morpholine base C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, C1-C6 Alkyl sulfoxide base C1-C6Alkyl, C1-C6Alkyl sulfuryl C1-C6Alkyl, C1-C6Alkyl carbonyl epoxide, C1-C6Alkoxy carbonyl oxygen Base, C1-C6Alkylaminocarbonyl epoxide, C1-C6Alkyl sulphonyl epoxide, halo C1-C6Alkyl sulphonyl epoxide, C1-C6Alkyl sulfonyl Amido, halo C1-C6Alkylsulfonamido, substituted or unsubstituted aryl carbonyl epoxide, substituted or unsubstituted aryloxycarbonyl It is epoxide, substituted or unsubstituted aryl amine carbonyl epoxide, substituted or unsubstituted Heteroarylcarbonyl epoxide, substituted or unsubstituted Heteroaryloxycarbonyl epoxide, substituted or unsubstituted heteroaryl amino-carbonyl epoxide, C1-C6Alkylamino radical thiocarbonyl epoxide, replace or Unsubstituted aryl amine thiocarbonyl epoxide, substituted or unsubstituted aryl C1-C6Alkoxyl, substituted or unsubstituted pyridine radicals C1-C6Alkoxyl, substituted or unsubstituted thiazolyl C1-C6Alkoxyl, C1-C6Alkyl-carbonyl amido, C1-C6Alkoxy carbonyl amine Base, C1-C6Alkylaminocarbonyl amido, C1-C6Alkylamino radical thiocarbonyl amido, substituted or unsubstituted aryl carbonyl amido, replacement Or unsubstituted aryloxycarbonyl amido, substituted or unsubstituted aryl amine carbonylamino, substituted or unsubstituted aryl amine sulfur For carbonylamino, substituted or unsubstituted Heteroarylcarbonyl amido, substituted or unsubstituted Heteroaryloxycarbonyl amido, replace or Unsubstituted heteroaryl amino-carbonyl amido, substituted or unsubstituted heteroaryl amido thiocarbonyl amido, amino carbonyl amido, C1-C6 Alkylamino radical, two (C1-C6) alkylamino radical, substituted or unsubstituted aryl C1-C6Alkylamino radical, substituted or unsubstituted pyridine radicals C1-C6 Alkylamino radical, substituted or unsubstituted thiazolyl C1-C6Alkylamino radical, N (t-Bu) (COPh), N=CHN (CH3)2, N=C (CH3)2、N =CHCF3, N=CHPh, N=CH (2-Py), N=CH (3-Py), N=CH (4-Py)；
R9Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl-carbonyl, halo C1- C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkylaminocarbonyl, halo C1-C6Alkylamino radical carbonyl Base, C1-C6Alkylamino radical thiocarbonyl, halo C1-C6Alkylamino radical thiocarbonyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6 Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkanamine Base carbonyl C1-C6Alkyl, halo C1-C6Alkylaminocarbonyl C1-C6Alkyl, substituted or unsubstituted aryl carbonyl, replacement do not take The aryloxycarbonyl in generation, substituted or unsubstituted Heteroarylcarbonyl, substituted or unsubstituted Heteroaryloxycarbonyl, replacement do not take The aryl amine carbonyl in generation, substituted or unsubstituted aryl amine thiocarbonyl, C1-C6Alkyl sulfinyl, halo C1-C6Alkane sulfenyl Base, C1-C6Alcoxyl sulfinyl, halo C1-C6Alcoxyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6 Alcoxyl sulfonyl, halo C1-C6Alcoxyl sulfonyl.
2. compound according to claim 1, it is characterised in that：In formula I
A, B may be the same or different, and be respectively and independently selected from O, S or NRa；Ra=H, CN, NO2、NH2Or NHCH3；
X is selected from H, halogen, CN, NO2、NH2, CHO, CH=NOCH3, CH=NNHCH3Or CH=NN (CH3)2；
Y is selected from O, S, S (=O), S (=NRb), S (=O)n(=NRb)2-n(n=1 or 2；Rb=H, CN, NO2) or NRc；Rc=H, CN、NO2、NH2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkylamino radical, halo C1-C6Alkylamino radical, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2- C6Alkynyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6 Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkane Epoxide carbonyl C1-C6Alkyl, substituted or unsubstituted aryl carbonyl, substituted or unsubstituted aryloxycarbonyl, replacement or unsubstituted Heteroarylcarbonyl, substituted or unsubstituted Heteroaryloxycarbonyl, substituted or unsubstituted aryl amine carbonyl, replace or it is unsubstituted Aryl amine thiocarbonyl, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alcoxyl sulfinyl, halo C1-C6 Alcoxyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alcoxyl sulfonyl, halo C1-C6Alcoxyl sulphonyl Base；
Z is selected from N or CRd；Rd=H, halogen or NO2；
R1Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halo C2- C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alcoxyl Asia sulphur Acyl group, halo C1-C6Alcoxyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alcoxyl sulfonyl, halo C1-C6Alcoxyl sulfonyl, amino C1-C6Alkyl, hydroxyl C1-C6Alkyl, sulfydryl C1-C6Alkyl, cyano group C1-C6Alkyl, cyano halo C1-C6Alkyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, halo C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkylamino radical C1-C6Alkyl, halo C1-C6Alkylamino radical C1-C6Alkyl, C1-C6Alkyl-carbonyl, Halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkylthiocarbonyl, halo C1-C6 Alkylthiocarbonyl, C1-C6Alkylaminocarbonyl, halo C1-C6Alkylaminocarbonyl, C1-C6Alkylamino radical thiocarbonyl, halo C1-C6Alkanamine Base thiocarbonyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6 Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkylaminocarbonyl C1-C6Alkyl, halo C1-C6Alkylaminocarbonyl C1- C6Alkyl, substituted or unsubstituted aryl C1-C6Alkyl, substituted or unsubstituted aryloxy group C1-C6It is alkyl, substituted or unsubstituted Aryl amine C1-C6Alkyl, substituted or unsubstituted heteroaryl C1-C6Alkyl, substituted or unsubstituted heteroaryloxy C1-C6Alkyl, Substituted or unsubstituted heteroaryl amido C1-C6Alkyl, substituted or unsubstituted aryl carbonyl C1-C6It is alkyl, substituted or unsubstituted Aryloxycarbonyl C1-C6Alkyl, substituted or unsubstituted aryl amine carbonyl C1-C6Alkyl, substituted or unsubstituted Heteroarylcarbonyl C1-C6Alkyl, substituted or unsubstituted Heteroaryloxycarbonyl C1-C6Alkyl, substituted or unsubstituted heteroaryl amino-carbonyl C1-C6Alkane Base, substituted or unsubstituted aryl carbonyl, substituted or unsubstituted aryloxycarbonyl, substituted or unsubstituted aryl amine carbonyl, Substituted or unsubstituted aryl amine thiocarbonyl, substituted or unsubstituted Heteroarylcarbonyl, substituted or unsubstituted heteroaryloxy Carbonyl, substituted or unsubstituted heteroaryl amino-carbonyl, substituted or unsubstituted heteroaryl amido thiocarbonyl；
R2,R3May be the same or different, be respectively selected from H, halogen, CN, NO2、NH2、CONH2、C1-C6Alkyl, halo C1-C6Alkyl, C2- C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkane Epoxide, halo C1-C6Alkoxyl, C1-C6Alkyl amine group, halo C1-C6Alkyl amine group, C1-C6Alkylthio group, halo C1-C6Alkane sulfur Base, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl Carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkylaminocarbonyl, halo C1-C6Alkylaminocarbonyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkane Base, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkoxyl, halo C1-C6Alkyl-carbonyl C1-C6Alcoxyl Base, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alcoxyl Base, halo C1-C6Alkoxy carbonyl C1-C6Alkoxyl；
R4Selected from H, halogen, CN, CONH2、CSNH2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkanes Base, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C2-C6Alkenyloxy group, halo C2-C6Alkenyloxy group, C2-C6Alkynyloxy group, halo C2-C6Alkynyloxy group, cyano group C1-C6Alkyl, cyano halo C1- C6Alkyl, cyano group C1-C6Alkoxyl, cyano halo C1-C6Alkoxyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxyl C1-C6Alkyl, C1-C6Alkyl sulfinyl epoxide, halo C1-C6Alkyl sulfinyl epoxide, C1-C6Alkyl sulfinyl amido, halo C1-C6Alkyl sulfinyl amido, C1-C6Alkyl sulfinyl epoxide C1-C6Alkyl, halo C1-C6Alkyl sulfinyl epoxide C1-C6Alkane Base, C1-C6Alkyl sulfinyl amido C1-C6Alkyl, halo C1-C6Alkyl sulfinyl amido C1-C6Alkyl, C1-C6Alkane sulfonyl oxygen Base, halo C1-C6Alkane sulfonyl epoxide, C1-C6Alkane sulfonyl amido, halo C1-C6Alkane sulfonyl amido, C1-C6Alkane sulfonyl oxygen Base C1-C6Alkyl, halo C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, C1-C6Alkane sulfonyl amido C1-C6Alkyl, halo C1-C6Alkane Sulfonyl amido C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkane Epoxide carbonyl, C1-C6Alkylaminocarbonyl, halo C1-C6Alkylaminocarbonyl, C1-C6Alkoxy carbonyl C1-C6Alkoxyl, halo C1- C6Alkoxy carbonyl C1-C6Alkoxyl, C1-C6Alkylaminocarbonyl C1-C6Alkoxyl, halo C1-C6Alkylaminocarbonyl C1-C6Alcoxyl Base, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, C1-C6Alkylaminocarbonyl C1-C6Alkane Base, halo C1-C6Alkylaminocarbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkane Base, C1-C6Alkyl-carbonyl C1-C6Alkoxyl, halo C1-C6Alkyl-carbonyl C1-C6Alkoxyl, substituted or unsubstituted aryl C1-C6 Alkyl, substituted or unsubstituted aryl C1-C6Alkoxyl, substituted or unsubstituted heteroaryl C1-C6Alkyl, replacement or unsubstituted Heteroaryl C1-C6Alkoxyl；
R5,R6May be the same or different, be respectively selected from H, halogen, CN, NO2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, Halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkyl ammonia Base, C2-C6Dialkyl amido, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkoxy C1-C6 Alkoxyl, halo C1-C6Alkoxy C1-C6Alkoxyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1- C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkoxyl, halo C1-C6Alkoxy carbonyl C1-C6Alkoxyl, C1-C6Alkyl-carbonyl C1- C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkyl-carbonyl C1-C6Alkoxyl, halo C1-C6Alkyl-carbonyl C1-C6 Alkoxyl；
R7Selected from H；C1-C6Alkyl, C3-C8Cycloalkyl, C2-C6Thiazolinyl, C2-C6Alkynyl, each of which is optionally by one or more Following substituent group replaces：Halogen, CN, NO2、OH、C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxyl, halo C1-C6Alkane Epoxide, C1-C6Alkylthio group, halo C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulphonyl Base, halo C1-C6Alkane sulfonyl, C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, phenyl, phenoxy group, 5 yuan of hetero-aromatic rings and 6 yuan are miscellaneous Aromatic ring；Phenyl, phenoxy group, 5 yuan of hetero-aromatic rings and 6 yuan of hetero-aromatic rings are each optionally independent selected from following substituent group by 1 to 3 Replace：C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, halogen, CN, NO2、C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkylthio group, C1-C6 Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl amino, C2- C6Dialkyl amido, C3-C8Cycloalkyl amino, C1-C6(alkyl) (cycloalkyl) amino, C1-C6Alkyl-carbonyl, C1-C6Alkoxyl carbonyl Base, C1-C6Alkyl amino-carbonyl, C2-C8Dialkyl amino carbonyl；
R8Selected from H, OH, NH2、C(CH3)2CH2S(O)(NH)CH3、C(CH3)2CH2S(O)(NCN)CH3、C1-C6Alkyl, halo C1- C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynes Base, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkoxy C1-C6Alkyl, C3-C8Cycloalkyl C1-C6Alkyl, C3-C8Oxa- Cycloalkyl C1-C6Alkyl, halo C3-C8Cycloalkyl C1-C6Alkyl, hydroxyl C1-C6Alkyl, C1-C6Alkyl amine group C1-C6Alkyl, two (C1-C6Alkyl) amido C1-C6Alkyl, substituted or unsubstituted pyridine radicals C1-C6Alkyl, substituted or unsubstituted thiazolyl C1-C6 Alkyl, substituted or unsubstituted pyridyloxy C1-C6Alkyl, substituted or unsubstituted pyridine thio C1-C6Alkyl, replacement or not Substituted pyridine amido C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkyl sulfoxide base C1-C6Alkyl, C1-C6Alkyl sulfone Base C1-C6Alkyl, C1-C6Alkyl carbonyl epoxide, C1-C6Alkoxy-carbonyl oxy, C1-C6Alkylaminocarbonyl epoxide, C1-C6Alkyl Sulfonyl epoxide, halo C1-C6Alkyl sulphonyl epoxide, C1-C6Alkylsulfonamido, halo C1-C6Alkylsulfonamido, replacement Or unsubstituted aryl carbonyl epoxide, substituted or unsubstituted aryloxycarbonyl epoxide, substituted or unsubstituted Heteroarylcarbonyl Epoxide, substituted or unsubstituted Heteroaryloxycarbonyl epoxide, C1-C6Alkylamino radical thiocarbonyl epoxide, substituted or unsubstituted arylamine Base thiocarbonyl epoxide, substituted or unsubstituted aryl C1-C6Alkoxyl, substituted or unsubstituted pyridine radicals C1-C6Alkoxyl, Substituted or unsubstituted thiazolyl C1-C6Alkoxyl, C1-C6Alkyl-carbonyl amido, C1-C6Alkoxycarbonylamino, C1-C6Alkanamine Base carbonylamino, C1-C6Alkylamino radical thiocarbonyl amido, substituted or unsubstituted aryl carbonyl amido, substituted or unsubstituted virtue Epoxide carbonyl amido, substituted or unsubstituted aryl amine carbonylamino, substituted or unsubstituted aryl amine thiocarbonyl amido, ammonia Base carbonylamino, C1-C6Alkylamino radical, two (C1-C6) alkylamino radical, substituted or unsubstituted aryl C1-C6Alkylamino radical, replacement do not take The pyridine radicals C in generation1-C6Alkylamino radical, substituted or unsubstituted thiazolyl C1-C6Alkylamino radical；
R9Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halo C2- C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halogen For C1-C6Alkoxy carbonyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkoxyl carbonyl Base C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6It is alkyl, substituted or unsubstituted aryl carbonyl, substituted or unsubstituted Aryloxycarbonyl, substituted or unsubstituted Heteroarylcarbonyl, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane Sulfonyl, halo C1-C6Alkane sulfonyl.
3. compound according to claim 2, it is characterised in that：In formula I
A, B may be the same or different, and be respectively and independently selected from O, S or NRa；Ra=H, CN, NO2；
X is selected from H, halogen, CN, NO2、NH2Or CHO；
Y is selected from O, S, S (=O), S (=NRb), S (=O)n(=NRb)2-n(n=1 or 2；Rb=H, CN, NO2) or NRc；Rc=H, CN、NO2、NH2、C1-C6Alkyl, halo C1-C6Alkyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynes Base, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl, C1-C6Alkane is sub- Sulfonyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl；
Z is selected from N or CRd；Rd=H, halogen or NO2；
R1Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynes Base, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, cyano group C1-C6 Alkyl, cyano halo C1-C6Alkyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, halo C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxyl carbonyl Base, halo C1-C6Alkoxy carbonyl, C1-C6Alkyl-carbonyl C1-C6Alkyl, halo C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkane Epoxide carbonyl C1-C6Alkyl, halo C1-C6Alkoxy carbonyl C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkyl, replacement Or unsubstituted heteroaryl C1-C6Alkyl, substituted or unsubstituted aryl carbonyl C1-C6Alkyl, substituted or unsubstituted heteroaryl Carbonyl C1-C6Alkyl；
R2,R3May be the same or different, be respectively selected from H, halogen, CN, NO2、NH2、CONH2、C1-C6Alkyl, halo C1-C6Alkyl, C2- C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C1-C6Alkane Epoxide, halo C1-C6Alkoxyl, C1-C6Alkyl amine group, halo C1-C6Alkyl amine group, C1-C6Alkylthio group, halo C1-C6Alkane sulfur Base, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl Carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl；
R4Selected from H, halogen, CN, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C2-C6Alkene oxygen Base, halo C2-C6Alkenyloxy group, C2-C6Alkynyloxy group, halo C2-C6Alkynyloxy group, cyano group C1-C6Alkyl, cyano halo C1-C6Alkyl, Cyano group C1-C6Alkoxyl, cyano halo C1-C6Alkoxyl, C1-C6Alkyl sulfinyl epoxide, halo C1-C6Alkyl sulfinyl epoxide, C1-C6Alkyl sulfinyl epoxide C1-C6Alkyl, halo C1-C6Alkyl sulfinyl epoxide C1-C6Alkyl, C1-C6Alkane sulfonyl epoxide, Halo C1-C6Alkane sulfonyl epoxide, C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, halo C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl；
R5,R6May be the same or different, be respectively selected from H, halogen, CN, NO2、C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, Halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, halo C1-C6Alkoxy carbonyl；
R7Selected from H；C1-C6Alkyl, C3-C8Cycloalkyl, C2-C6Thiazolinyl, C2-C6Alkynyl, each of which is optionally by one or more Following substituent group replaces：Halogen, CN, NO2、OH、C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxyl, halo C1-C6Alkane Epoxide, C1-C6Alkylthio group, halo C1-C6Alkylthio group, C1-C6Alkyl sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulphonyl Base, halo C1-C6Alkane sulfonyl, C1-C6Alkyl-carbonyl, C1-C6Alkoxy carbonyl, phenyl, phenoxy group, 5 yuan of hetero-aromatic rings and 6 yuan are miscellaneous Aromatic ring；
R8Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C3-C8Cycloalkyl, halo C3-C8Cycloalkyl, C2-C6Thiazolinyl, halo C2- C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkoxy C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, C3-C8Cycloalkyl C1-C6Alkyl, halo C3-C8Cycloalkyl C1-C6Alkyl, hydroxyl C1-C6Alkyl, Two (C1-C6Alkyl) amido C1-C6Alkyl, C3-C8Oxacycloalkyl C1-C6Alkyl, substituted or unsubstituted pyridine radicals C1-C6Alkane Base, substituted or unsubstituted thiazolyl C1-C6Alkyl, C1-C6Alkylthio group C1-C6Alkyl, C1-C6Alkyl sulfoxide base C1-C6Alkyl, C1-C6Alkyl sulfuryl C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkoxyl, substituted or unsubstituted pyridine radicals C1-C6Alkane Epoxide, substituted or unsubstituted thiazolyl C1-C6Alkoxyl；
R9Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxyl carbonyl Base, halo C1-C6Alkoxy carbonyl, the substituted or unsubstituted Heteroarylcarbonyl of substituted or unsubstituted aryl carbonyl, C1-C6Alkane Sulfinyl, halo C1-C6Alkyl sulfinyl, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl.
4. compound according to claim 3, it is characterised in that：In formula I
A, B may be the same or different, and be respectively and independently selected from O, S or NRa；Ra=H or CN；
X is selected from H, halogen or CN；
Y is selected from O, S, S (=O), S (=O)2Or NRc；Rc=H or CN；
Z is selected from N or CRd；Rd=H, halogen or NO2；
R1Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkyl sulfinyl, halo C1-C6Alkane sulfenyl Base, C1-C6Alkane sulfonyl, halo C1-C6Alkane sulfonyl, cyano group C1-C6Alkyl, cyano halo C1-C6Alkyl, C1-C6Alkoxyl carbonyl Base, C1-C6Alkyl-carbonyl C1-C6Alkyl, C1-C6Alkoxy carbonyl C1-C6Alkyl, substituted or unsubstituted aryl C1-C6Alkyl, Substituted or unsubstituted heteroaryl C1-C6Alkyl；
R2,R3May be the same or different, be respectively selected from H, halogen, CN, NO2、NH2、CONH2、C1-C6Alkyl, halo C1-C6Alkyl, C2- C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, C1-C6Alkane Sulfenyl, halo C1-C6Alkylthio group；
R4Selected from H, halogen, CN, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxyl, halo C1-C6Alkoxyl, cyano group C1-C6 Alkyl, cyano group C1-C6Alkoxyl, cyano halo C1-C6Alkoxyl, C1-C6Alkane sulfonyl epoxide, halo C1-C6Alkane sulfonyl oxygen Base, C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, halo C1-C6Alkane sulfonyl epoxide C1-C6Alkyl, C1-C6Alkoxy carbonyl；
R5,R6May be the same or different, be respectively selected from H, halogen, CN, CF3Or NO2；
R7Selected from H；C1-C6Alkyl, C3-C8Cycloalkyl, C2-C6Thiazolinyl or C2-C6Alkynyl；
R8Selected from H,C1-C6Alkyl, halo C1-C6Alkyl, C2-C6Thiazolinyl, C2-C6Alkynyl, C3-C8Cycloalkyl, C (CH3)2CH2SCH3、CH2CH2CH2N(CH3)2、CH(CH3)CH2OH、
R9Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkyl-carbonyl, halo C1-C6Alkyl-carbonyl, C1-C6Alkoxyl carbonyl Base or halo C1-C6Alkoxy carbonyl.
5. compound according to claim 4, it is characterised in that：In formula I
A, B may be the same or different, and be respectively and independently selected from O, S or NH；
X is selected from H, F, Cl, Br, I or CN；
Y is selected from O, S, S (=O), S (=O)2Or NRc；Rc=H or CN；
Z is selected from N or CRd；Rd=H, F, Cl or Br；
R1Selected from H, C1-C6Alkyl, halo C1-C6Alkyl, C1-C6Alkoxy C1-C6Alkyl, halo C1-C6Alkoxy C1-C6Alkyl, C2-C6Thiazolinyl, halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl, cyano group C1-C6Alkyl, cyano halo C1-C6Alkyl, CH2Ph、
R2,R3May be the same or different, be respectively selected from H, F, Cl, Br, I, CN, C1-C6Alkyl, halo C1-C6Alkyl, C2-C6Thiazolinyl, Halo C2-C6Thiazolinyl, C2-C6Alkynyl, halo C2-C6Alkynyl；
R4Selected from H, F, Cl, Br, I, C1-C3Alkoxyl, halo C1-C3Alkoxyl, cyano group C1-C3Alkyl, cyano group C1-C3Alkoxyl Or CN；
R5,R6May be the same or different, be respectively selected from H, F, Cl, Br, I, CN, CF3Or NO2；
R7Selected from H or C1-C6Alkyl；
R8Selected from H, CH3、CH2CH3、CH(CH3)2、C(CH3)3、CH2CH=CH2、CH2C≡CH、C(CH3)2C≡CH、C(CH3)2CH2SCH3、CH2CH2Cl、CH2CH2Br, cyclopropyl, CH2CH2CH2N(CH3)2、CH(CH3) CH2OH、
R9Selected from H or C1-C6Alkyl.
6. compound according to claim 5, it is characterised in that：In formula I
A, B may be the same or different, and be respectively and independently selected from O or S；
X is selected from H, F, Cl or CN；
Y is selected from O, S, S (=O) or S (=O)2；
Z is selected from N or CRd；Rd=H, F or Cl；
R1Selected from H, CH3、CH2CH3、CH2CH2CH3、CH(CH3)2、C(CH3)3、CF3、CF2H、CFH2、CCl3、CCl2H、CClH2、 CFClH、CF2CF2H、CH2CF3、CH2OCH3、CH2CH=CH2、CH2CH=CHCl, CH2C≡CH、CH2C≡CI、CH2CN、 CH2Ph、
R2,R3May be the same or different, be respectively selected from H, F, Cl, Br, CN, CH3、CH2CH3、CH2CH2CH3、CH(CH3)2、CH2F、 CF2H、CF3、CH2Cl、CCl2H、CCl3、CFClH；
R4Selected from F, Cl, Br, OCH3、OCH2CH3、OCF3、OCHF2、OCH2F、OCCl3、OCHCl2、OCH2Cl、OCHFCl、 OCF2CF2H、OCH2CF3、CH2CN、OCH2CN or CN；
R5,R6May be the same or different, be respectively selected from H, F, Cl, Br, CF3Or CN；
R7Selected from H, CH3、CH2CH3、CH2CH2CH3、CH(CH3)2、C(CH3)3；
R8Selected from H, CH3、CH2CH3、CH(CH3)2、C(CH3)3、CH2CH=CH2、CH2C≡CH、C(CH3)2C≡CH、C(CH3)2CH2SCH3、CH2CH2Cl、CH2CH2Br, cyclopropyl, CH2CH2CH2N(CH3)2、CH(CH3) CH2OH、
R9Selected from H or CH3。
7. application of a kind of compound of Formula I as claimed in claim 1 in agricultural or other field as insecticide.
8. application of a kind of compound of Formula I as claimed in claim 1 in agricultural or other field as antibacterial.
9. a kind of Pesticidal combination, the compound of Formula I as claimed in claim 1 comprising biology effective dose and at least one Selected from the annexing ingredient of surfactant, solid diluent or liquid diluent.
10. a kind of parasite killing, bactericidal composition, it is characterised in that：Containing compound of Formula I as claimed in claim 1 and agricultural Upper acceptable carrier, in compositionss, the weight percentage of active component is 0.1-99%.
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CN107197868A (en) * 2016-03-19 2017-09-26 海利尔药业集团股份有限公司 A kind of bigcatkin willow insect amide insecticide and its application
WO2019123194A1 (en) 2017-12-20 2019-06-27 Pi Industries Ltd. Anthranilamides, their use as insecticide and processes for preparing the same.
WO2019150220A1 (en) 2018-01-30 2019-08-08 Pi Industries Ltd. Novel anthranilamides, their use as insecticide and processes for preparing the same.
CN110835331A (en) * 2018-08-15 2020-02-25 海利尔药业集团股份有限公司 Preparation method of substituted salicylamide compound with insecticidal activity
WO2023012081A1 (en) 2021-08-05 2023-02-09 Syngenta Crop Protection Ag Method for controlling diamide resistant pests & compounds therefor

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CN1541063A (en) * 2001-08-13 2004-10-27 ��Ļ���Ű˾ Method for controlling particular insects by applying anthranilamide compounds
WO2008031548A1 (en) * 2006-09-11 2008-03-20 Syngenta Participations Ag Process for the preparation of anthranilamide derivatives
CN104270946A (en) * 2011-12-19 2015-01-07 拜耳农作物科学股份公司 Use of anthranilic acid diamide derivatives for pest control in transgenic crops

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Publication number Priority date Publication date Assignee Title
CN1541063A (en) * 2001-08-13 2004-10-27 ��Ļ���Ű˾ Method for controlling particular insects by applying anthranilamide compounds
WO2008031548A1 (en) * 2006-09-11 2008-03-20 Syngenta Participations Ag Process for the preparation of anthranilamide derivatives
CN104270946A (en) * 2011-12-19 2015-01-07 拜耳农作物科学股份公司 Use of anthranilic acid diamide derivatives for pest control in transgenic crops

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107197868A (en) * 2016-03-19 2017-09-26 海利尔药业集团股份有限公司 A kind of bigcatkin willow insect amide insecticide and its application
WO2019123194A1 (en) 2017-12-20 2019-06-27 Pi Industries Ltd. Anthranilamides, their use as insecticide and processes for preparing the same.
WO2019150220A1 (en) 2018-01-30 2019-08-08 Pi Industries Ltd. Novel anthranilamides, their use as insecticide and processes for preparing the same.
CN110835331A (en) * 2018-08-15 2020-02-25 海利尔药业集团股份有限公司 Preparation method of substituted salicylamide compound with insecticidal activity
WO2023012081A1 (en) 2021-08-05 2023-02-09 Syngenta Crop Protection Ag Method for controlling diamide resistant pests & compounds therefor

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