CN106388800A - Catheter capable of measuring pressure in blood vessel - Google Patents
Catheter capable of measuring pressure in blood vessel Download PDFInfo
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- CN106388800A CN106388800A CN201610911057.6A CN201610911057A CN106388800A CN 106388800 A CN106388800 A CN 106388800A CN 201610911057 A CN201610911057 A CN 201610911057A CN 106388800 A CN106388800 A CN 106388800A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6851—Guide wires
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
- A61B5/6855—Catheters with a distal curved tip
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0247—Pressure sensors
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- Heart & Thoracic Surgery (AREA)
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- Vascular Medicine (AREA)
- Physiology (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention provides a catheter capable of measuring pressure in a blood vessel, comprising a distal cannula, a pressure sensor and a proximal part, wherein the distal cannula is provided with a conducting wire inner chamber, the conducting wire inner chamber can receive a separate medical conducting wire in a sliding manner, the pressure sensor is arranged outside the distal cannula, and is arranged to measure blood pressure in the blood vessel and generate a blood pressure signal, the proximal part is coupled with the distal cannula, and comprises a signal channel and a connecting catheter, the signal channel is arranged to transmit the blood pressure signal from the pressure sensor, the connecting catheter is arranged to support the signal channel and move the distal cannula, an annular cannula is arranged at the front end of the distal cannula as a location identifier, and the annular cannula has flexibility and comprises a material non-transparent to X rays. According to the catheter capable of measuring the pressure in the blood vessel provided by the invention, as the annular cannula which has the flexibility and comprises the material non-transparent to the X rays is provided as the location identifier, position of the pressure sensor can be located conveniently, and injury to the blood vessel caused during the operation is reduced.
Description
The application isOn 02 19th, 2016, Application No.201610095320.9, invention entitledBlood vessel Interior pressure measurement conduitsPatent application divisional application.
Technical field
The present invention relates to a kind of intravascular pressure measures conduit.
Background technology
For many cardiovascular diseasess such as coronary heart disease, percutaneous coronary intervention (pci) (PCI) is relatively effective at present
Treatment meanss.Tradition judges whether that the method implementing interventional therapy (such as angioplasty or support are placed) is that doctor passes through to be preced with
Arteries and veins radiography is estimating the stenosis of arteria coronaria blood vessel.However, this traditional determination methods can not help doctor to make very
Accurately judge and it is possible to doctor's over-treatment can be led to.
In recent years, in order to more accurately judge whether patient really needs to implement interventional therapy, using assessment stenotic lesion
The blood flow reserve fraction (Fractional Flow Reverse, abbreviation FFR) blocking the degree that blood flows through blood vessel increasingly obtains
To application and popularization.FFR is defined as the ratio of the maximum blood flow in artery stenosis and normal maximum blood flow.In order to calculate Ink vessel transfusing
The FFR of given narrow (being possible to place the position of intravascular stent), needs to measure and gather narrow distal side (example respectively
As narrow downstream) and narrow proximal lateral (for example narrow upstream, near aorta) blood pressure readings.Clinical research table
Bright, narrowness is higher, and FFR value is lower, FFR value whether less than assessed value (such as 0.8) can as useful criterion,
May decide that to whether such patient implements interventional therapy based on this standard doctor.The effectiveness of this criterion has also obtained
Confirmation to American-European multiple large-scale clinical study results (such as FAME clinical research).
At present, as the method for blood pressure in measurement patient's blood vessel, for example, there is the method using pressure-sensing seal wire.This pressure
Power sensing seal wire is internally provided with pressure transducer in seal wire.Before carrying out calcification score, by pressure-sensing seal wire through narrow
Narrow distal side and proximal lateral, record far-end blood pressure and near-end blood pressure respectively.Thus, it is possible to calculate narrow FFR value.
Content of the invention
However, for existing pressure-sensing seal wire, due to being provided with pressure transducer inside seal wire, therefore its performance
The conventional guidewire (being for example used for placing the seal wire of foley's tube or scaffold tube) being used with doctor is had differences, such pressure
The sensing usual hardness of seal wire is bigger, and operation controllability has also declined, and is likely to not easily pass through for complex lesions region.Cause
This, doctor, when carrying out intravascular pressure measurement and interventional therapy to complex lesions region, generally requires to change seal wire, and changes
Seal wire can increase complexity and the risk of operation.In addition, for a lot of doctors, having got used to using some specific chis
Seal wire that is very little, possessing good pliability and turn round control property.Therefore, allow doctor reuse other kinds of seal wire and carry out intervention to control
Treat it is also possible to time and the difficulty of interventional therapy (for example seal wire being navigated to stenotic lesion) can be increased.
The present invention completes in view of the situation of above-mentioned prior art, its object is to provide one kind can be easy to doctor and make
It is applied to the intravascular pressure measurement conduit of interventional therapy.
For this reason, the invention provides a kind of intravascular pressure measurement conduit it is characterised in that：Including：Distal cannula, its tool
There is the guidewire lumen slideably received within single medical guiding wire；Pressure transducer, it is arranged on the outside of described distal cannula,
For measuring endovascular blood pressure and producing blood pressure signal；And proximal part, it is coupled with described distal cannula, and includes
And it is used for supporting described signal path simultaneously from the signal path of the described blood pressure signal of described pressure transducer for transmission
The connecting conduit of mobile described distal cannula, in the front end of described distal cannula, is provided with the ring-shaped sleeve as positioning mark,
Described ring-shaped sleeve has pliability and comprises the opaque material to X-ray.
In intravascular pressure measurement conduit involved in the present invention, only distal cannula is limited by medical guiding wire, therefore, doctor
Intravascular pressure measurement conduit can be rapidly changed in life, and is capable of the conventional guidewire of compatible doctor at present use, so as to
Enough allow doctor complete the measurement of intravascular pressure under familiar operating environment, reduce time of measuring, reduce operational risk, significantly
The convenience of lifting intravascular pressure measurement and operability.Further, since in the front end of described distal cannula, being provided with and have
Pliability and comprise the ring-shaped sleeve to the opaque material of X-ray as positioning mark.Therefore, it is possible to facilitate positioning pressure to pass
The position of sensor, even and if slide and the blood vessel near touching along medical guiding wire in distal cannula, due to being arranged on far-end
The ring-shaped sleeve foremost of sleeve pipe has pliability, therefore also can reduce the damage that blood vessel is caused.
In addition, in intravascular pressure measurement conduit involved in the present invention, alternatively, being also equipped with coating described far-end set
Pipe and the outer tube of described pressure transducer.Thereby, it is possible to protect distal cannula and pressure transducer.
In addition, in intravascular pressure measurement conduit involved in the present invention, alternatively, described distal cannula is near with described
End lease making is coupled by described outer tube.Thereby, it is possible to distal cannula and proximal part be realized coupling by outer tube.
In addition, in intravascular pressure measurement conduit involved in the present invention, alternatively, described guidewire lumen is slidably
Receive the medical guiding wire with external diameter about 0.2mm to 1mm.Thereby, it is possible to improve intravascular pressure measurement involved in the present invention
The suitability of conduit.
In addition, in intravascular pressure measurement conduit involved in the present invention, alternatively, described guidewire lumen includes tubular
Inner chamber and extend to from described tubular inner chamber described outer tube side bending inner chamber.In this case, can make medical
Seal wire more easily in intravasation pressure measurement conduits guidewire lumen, be conducive to medical guiding wire in the shifting of guidewire lumen
Dynamic.
In addition, in intravascular pressure measurement conduit involved in the present invention, alternatively, described pressure transducer is arranged on
On the outer surface of described distal cannula, and near described ring-shaped sleeve.Thereby, it is possible to facilitate doctor to wait by ring-shaped sleeve
Position to position for pressure transducer.
In addition, in intravascular pressure measurement conduit involved in the present invention, alternatively, described distal cannula have along
The perforate of the length direction of described distal cannula, described perforate allows blood flow to flow into described guidewire lumen.Thereby, it is possible to reduce blood
Overpressure measures the use resistance of conduit.
In addition, in intravascular pressure measurement conduit involved in the present invention, alternatively, it is described that described outer tube has permission
Pressure transducer measures the opening of blood pressure.Thereby, it is possible to facilitate intravascular pressure measurement conduit that endovascular blood flow is pressed
Power measures.
In addition, in intravascular pressure measurement conduit involved in the present invention, alternatively, described signal path is at least part of
Be contained in described connecting conduit.Thereby, it is possible to provide protection structure for signal path.
In addition, measuring in conduit in intravascular pressure involved in the present invention, alternatively, described distal cannula and described ring
Shape sleeve pipe is coaxial.Thereby, it is possible to make medical guiding wire easily pass in and out distal cannula and ring-shaped sleeve.
Brief description
The intravascular pressure that Fig. 1 shows involved by embodiments of the present invention measures the three-dimensional structure diagram of conduit.
The intravascular pressure that Fig. 2 shows involved by embodiments of the present invention measures dividing after separating outer tube in conduit
Solution schematic diagram.
The intravascular pressure measurement conduit that Fig. 3 shows involved by embodiments of the present invention slips over showing of medical guiding wire
It is intended to.
Fig. 4 shows the schematic section that the intravascular pressure shown in Fig. 1 measures conduit.
Fig. 5 show involved by embodiments of the present invention intravascular pressure measurement conduit includes ring-shaped sleeve with
The surface figure of pressure transducer.
The intravascular pressure that Fig. 6 shows involved by Fig. 5 measures the close-up schematic view of conduit.
Fig. 7 is the schematic cross-section of the blood vessel of intravascular pressure measurement conduit involved by embodiments of the present invention.
Fig. 8 is that the intravascular pressure involved by embodiments of the present invention measures conduit along the section in length of vessel direction
Schematic diagram.
Fig. 9 shows the flow process of the method measuring conduit using the intravascular pressure involved by embodiments of the present invention
Figure.
Symbol description：
1 ... intravascular pressure measurement conduit (blood pressure measurement conduit), 2 ... medical guiding wires, 10 ... distal cannula, 12 ... seal wires
Inner chamber, 14 ... ring-shaped sleeves, 20 ... proximal parts, 22 ... signal paths, 30 ... outer tubes, 32 ... openings, 34 ... side openings, 40 ...
Pressure transducer, 100 ... blood vessels.
Specific embodiment
Hereinafter, refer to the attached drawing, explains the preferred embodiment of the present invention.In the following description, for identical
Part give identical symbol, the repetitive description thereof will be omitted.In addition, accompanying drawing is simply schematically schemed, part chi each other
Shape of very little ratio or part etc. can be different from actual.
Fig. 1 shows that the intravascular pressure of embodiment involved in the present invention measures the three-dimensional structure diagram of conduit.Fig. 2 is
Show that the decomposing schematic representation after separating outer tube in the intravascular pressure measurement conduit involved by embodiments of the present invention is (empty
Line part represents the partial-length eliminating intravascular pressure measurement conduit).Fig. 3 shows involved by embodiments of the present invention
And intravascular pressure measure conduit and slip over the schematic diagram of medical guiding wire.
As shown in figure 1, intravascular pressure measurement conduit 1 (below, being sometimes also referred to as " blood pressure measurement conduit 1 ") is included far
End sleeve pipe 10 and the proximal part 20 coupling with distal cannula 10.In addition, in the present embodiment, distal cannula 10 and close end
Divide 20 can couple via outer tube 30.
Although showing that distal cannula 10 is coupled via outer tube 30 with proximal part 20 in the present embodiment, this reality
Apply mode not limited to this.For example, distal cannula 10 can also be coupled it is also possible to by outer tube 30 by welding with proximal part 20
Integrally formed with proximal part 20 forming draw bail.
As shown in Fig. 2 in blood pressure measurement conduit 1 involved by present embodiment, distal cannula 10 has guidewire lumen
12.Guidewire lumen 12 is slideably received within single medical guiding wire 2.Therefore, by making distal cannula 10 receive and along medical
Seal wire 2 slides, and distal cannula 10 and the pressure transducer 40 being arranged in distal cannula 10 can be sent in patient body (for example
Vein, tremulous pulse) precalculated position.Thereby, it is possible to carry out blood pressure measurement to obtain this to this precalculated position (such as lesions position)
The reading of the blood flow reserve fraction (FFR) of position, provides reference for follow-up interventional therapy.
As described above, the value (referred to as " FFR value ") of blood flow reserve fraction (FFR) can be used for assessing stenotic lesion obstruction blood
Liquor stream crosses the degree of blood vessel, provides the decision-making whether carrying out interventional therapy for doctor etc..In general, it is given narrow in order to calculate
FFR value, need to measure and gather narrow distal side (for example, narrow downstream) respectively and narrow proximal lateral be (for example narrow
Narrow upstream, near aorta) blood pressure readings.The blood pressure gradient of stenotic lesion reflects the instruction of narrow seriousness.Narrow
Degree is more serious, and pressure drop is bigger, and FFR value is lower.
Proximal part 20 mainly include for transmission from pressure transducer 40 blood pressure signal signal path 22 and
For supporting the connecting conduit 24 of signal path 22 mobile distal cannula 10.In the present embodiment, the structure of proximal part 20
Become material to be not particularly limited, preferably use the higher material of hardness, to guarantee that doctor can pass through in interventional procedure
Distal cannula 10 (and the pressure transducer 40 being arranged in distal cannula 10) is advanced by proximal part 20 along medical guiding wire 2
To in patient's blood vessel, and then position to stenotic lesion.
Proximal part 20 is generally harder than distal cannula 10 and has more rigidity, so as to preferably moving and advancing
Distal cannula 10.In the present embodiment, proximal part 20 can be made up of medical stainless steel.In addition, proximal part 20 also may be used
To be made up of other materials such as Nitinol, nylon, plastics etc..
In the present embodiment, signal path 22 is communicated to equipment such as processor, display, meter outside positioned at patient
The armarium such as calculation machine, monitor.In addition, signal path 22 can also be arranged in connecting conduit 24, make connecting conduit 24 to
Partially coat signal path 22, that is, signal path 22 is at least partially recessed in connecting conduit 24.Thus, connecting conduit
24 can play support and protection signal path 22.In addition, in certain embodiments, signal path 22 can also be along close end
Divide 20 outer surface configuration.
Fig. 4 shows the schematic section that the intravascular pressure shown in Fig. 1 measures conduit.Fig. 5 shows the present invention
Intravascular pressure involved by embodiment measure the surface figure that conduit includes ring-shaped sleeve and pressure transducer.Figure
6 intravascular pressures showing involved by Fig. 5 measure the close-up schematic view of conduit.
In the present embodiment, as shown in Figure 2, Figure 5 and Figure 6, pressure transducer 40 is arranged on the outside of distal cannula 10.
Pressure transducer 40 (being more specifically the measuring point 41 of pressure transducer 40) can sense and/or measure the blood vessel of patient
Interior blood pressure, and produce blood pressure signal.Pressure transducer 40 and signal path 22 be connected, blood produced by pressure transducer 40
Pressure signal is sent to for example external processing equipment (not shown) via signal path 22.
In addition, in the present embodiment, pressure transducer 40 can be capacitance pressure transducer, resistive pressure sensing
Device etc..In addition, pressure transducer 40 can also be MEMS pressure sensor.For example, the measurement range of pressure transducer 40 be about-
50mm Hg to about 300mm Hg.According to the type of pressure transducer 40, signal path 22 can be that conducting medium is for example electric
Wire.Additionally, in certain embodiments, signal path 22 can also be wireless communication line, infrared communication link or ultrasound wave
Communication line.
In the present invention, blood pressure measurement conduit 1 can be entered respectively as single device with medical guiding wire 2 or exit disease
In human body.In this case, doctor being capable of independently controlled blood pressure measurement conduit 1 and medical guiding wire 2.By by blood pressure measurement
Conduit 1 and medical guiding wire 2, as single device, can make doctor more easily operate blood pressure measurement conduit 1 and medical lead
Silk 2.
In addition, the length of blood pressure measurement conduit 1 and medical guiding wire 2 is not particularly limited, from the viewpoint being easy to interventional therapy
See, for example length is about 160cm to 220cm.In addition, distal cannula 10 length is it is not also specifically limited, for example can be about 5cm
～20cm.In this case, because distal cannula 10 is much smaller than the length of medical guiding wire 2, therefore, doctor waits in operation blood pressure
During measurement conduit 1, can rapidly change blood pressure measurement conduit 1.
In general, during interventional therapy, the operator such as doctor certain position (example first from a patient
At thigh tremulous pulse) along blood vessel, guiding catheter (not shown) is advanced at the coronary artery of such as heart, then, by example
As contrast agent, medical guiding wire 2 is propelled further into it may happen that the less blood vessel of pathological changes along this guiding catheter
Position.In this case, blood pressure measurement conduit 1 passes through distal cannula 10 through (referring to Fig. 3) on this medical guiding wire 2, makes
Guidewire lumen 12 slips over medical guiding wire 2, and by operate connecting conduit 24 outside (for example push away and/or draw) patient (or
The operation device (not shown) that person is connected with connecting conduit 24) (and it is arranged in distal cannula 10 moving distal cannula 10
Pressure transducer 40), until pressure transducer 40 is in predetermined position.
In the present embodiment, the size of guidewire lumen 12 is not particularly limited, for example, can receive and slip over about 0.2mm
Medical guiding wire to 1mm overall diameter.In addition, guidewire lumen 12 can also receive and slip over specific criteria in interventional therapy field
The medical guiding wire of size.
In addition, in the front end of distal cannula 10, being provided with the ring-shaped sleeve 14 as positioning mark.Ring-shaped sleeve 14 has
Pliability and comprise the opaque material to X-ray.Because ring-shaped sleeve 14 has pliability, therefore blood pressure measurement conduit 1
When the blood vessel of patient is mobile, noinvasive can be realized for blood vessel.In the present embodiment, ring-shaped sleeve 14 is preferably provided at far
(end) foremost of end sleeve pipe 10.As the ring-shaped sleeve 14 of mark, pressure transducer 40 can be navigated under X-ray and exist
Position in blood vessel.
In the present embodiment, as described above, in carrying out interventional procedure, needing by operating proximal part 20
(specifically connecting conduit 24) is moving distal cannula 10.When moving in intravascular along medical guiding wire 2 or adjust distal cannula
When 10, distal cannula 10 is possible to touch blood vessel near distal cannula 10 or the larger position of blood vessel curvature.This
In the case of, even if the blood vessel near sliding along medical guiding wire 2 in distal cannula 10 and touching, due to being arranged on distal cannula 10
Ring-shaped sleeve 14 foremost there is pliability, therefore also can reduce the damage that blood vessel is caused.
In addition, in the present embodiment, because ring-shaped sleeve 14 comprises the opaque material to X-ray, therefore, work as human body
When being irradiated by X-ray, ring-shaped sleeve 14 can form opaque pattern.By this opaque pattern, doctor etc.
Corresponding positioning mark can be quickly found.Therefore, in the present embodiment, ring-shaped sleeve 14 is also used as distal cannula
10 and pressure transducer 40 positioning being arranged in distal cannula 10 marks using.Furthermore it is preferred that pressure transducer 40
It is arranged on the position near ring-shaped sleeve 14 in distal cannula 10, thus can be positioned by the mark action of ring-shaped sleeve 14
Go out the approximate location of pressure transducer 40.
As an embodiment of present embodiment, outer tube 30 can coat distal cannula 10 and pressure transducer 40.Separately
Outward, outer tube 30 has and measures the opening 32 of blood pressure and right with the guidewire lumen 12 of distal cannula 10 for pressure transducer 40
The side opening 34 answered.The size of opening 32 is not particularly limited, as long as corresponding to the big of the measuring point 41 of pressure transducer 40
Little.
In the present embodiment, because outer tube 30 has the corresponding opening 32 in measuring point 41 with pressure transducer 40,
Therefore, endovascular blood flow can enter the opening 32 of outer tube 30, can be measured near opening 32 by this pressure transducer 40
Blood pressure.
Further, since outer tube 30 cladding distal cannula 10 and pressure transducer 40, distal cannula 10 therefore can also be improved
Structural stability with the pressure transducer 40 being arranged in distal cannula 10.
In addition, the outer surface of outer tube 30 is preferably tangent with ring-shaped sleeve 14, distal cannula 10 and ring thus can be improved
The operability of shape sleeve pipe 14.The material of outer tube 30 can be sub- for polyester, polyamide, nylon, nylon elastomer, polyurethane, polyamides
Amine etc...
In addition, in the present embodiment, outer tube 30 can be passed through, using mode physically or chemically include sweat soldering,
Distal cannula 10 is coupled by the modes such as laser welding, medical bonding with proximal part 20.Due to being arranged in distal cannula 10
Pressure transducer 40 is coated by outer tube 30, and therefore, pressure transducer 40 obtains the protection of outer tube 30 at least in part.
In addition, outer tube 30 can become a part for distal cannula 10 forming process.For example, will by using welding manner
Outer tube 30 is closely connected with distal cannula 10.In addition, the guidewire lumen 12 of distal cannula 10 can melt molding by heat being formed.
In embodiments of the present invention, can be in the gel filled such as Medical silicone gels in the inner side of outer tube 30.If
Surrounding's filling medical gel of the pressure transducer 40 of outer tube 30 inner side, then foreign matter will not be easily penetrate into the interior of outer tube 30
Portion, thus the reliability improving pressure transducer 40 and transmitting the signal path of blood pressure signal being produced by pressure transducer 40.
In addition, Silica hydrogel can also provide additional structural capacity for pressure transducer 40.
As shown in figure 4, in distal cannula 10, guidewire lumen 12 includes tubular inner chamber 12a and continues from tubular inner chamber 12a
Bending inner chamber 12b to outer tube 30 side (side opening 34).Here, tubular inner chamber 12a is connected with bending inner chamber 12b, and curved
Bent inner chamber 12b is connected with the side opening 34 of outer tube 30, so that it is guaranteed that medical guiding wire 2 can enter via the side opening 34 of outer tube 30
Guidewire lumen 12 or exit from side opening 34.
Tubular inner chamber 12a is located at the inside of distal cannula 10.In addition, as shown in figure 4, the tubular inner chamber of distal cannula 10
12a and ring-shaped sleeve 14 are coaxial and/or concentric.In addition, the internal diameter of tubular inner chamber 12a can be with ring-shaped sleeve 14
Internal diameter is substantially the same.In certain embodiments, ring-shaped sleeve 14 can be bonded in the end of distal cannula 10 by for example welding
End (i.e. foremost).
In addition, in certain embodiments, the external diameter of ring-shaped sleeve 14 can be slightly larger than the external diameter of tubular inner chamber 12a.At this
In the case of kind, the external diameter of ring-shaped sleeve 14 can be roughly the same with the external diameter of outer tube 30.Additionally, in certain embodiments, ring-type
Sleeve pipe 14 can be shaped generally as hollow round table shape, and its outer distal cannula 10 without leave is gradually reduced.
In addition, in the present embodiment, because pressure transducer 40 is arranged on the side of distal cannula 10, therefore, from for
Preferably from the viewpoint of parcel pressure transducer 40 and distal cannula 10, ring-shaped sleeve 14 can be formed adjacent to pressure sensing
The bigger ellipticity of the ring wall thickness of the side of device 40.
In guidewire lumen 12, bending inner chamber 12b extends to outer tube 30 side from tubular inner chamber 12a.Correspondingly, outer tube 30
It is formed with side opening 34 corresponding with bending inner chamber 12b.Specifically, the internal diameter axis of guidewire lumen 12 is from tubular inner chamber 12a
Gradually change to bending inner chamber 12b, and bend the internal diameter axis of close outer tube 30 side of inner chamber 12b and guidewire lumen 12
Tubular inner chamber 12a internal diameter axis produce deviate.By this configuration of guidewire lumen 12, can allow for medical guiding wire 2 via
Side opening 34 enters the guidewire lumen 12 of distal cannula 10, thus being conducive to medical guiding wire 2 to slide in guidewire lumen 12.In this reality
Apply in mode, during due to measuring in the FFR carrying out interventional therapy using blood pressure measurement conduit 1, blood pressure measurement conduit 1 only has far-end
Part 10 is limited in medical guiding wire 2 slides, and therefore, doctor etc. can rapidly operate and change involved by present embodiment
Blood pressure measurement conduit 1, thus, it is possible to improve the procedure efficiency of interventional therapy.
In the present embodiment, it is sent to pre- in patient's blood vessel because distal cannula 10 moves along medical guiding wire 2
Positioning is put, and therefore, does not need to reorientate medical when operating the blood pressure measurement conduit 1 involved by embodiments of the present invention
Seal wire 2.
Specifically, for example when the pressure transducer 40 on blood pressure measurement conduit 1, to be positioned in narrow far-end (for example narrow
Narrow downstream) when, measure the blood pressure of narrow remote end side first.Then, the position of medical guiding wire 2 can be adjusted, by moving
Dynamic (for example, advance and/or retract) distal cannula 10 just can make pressure transducer 40 reach narrow proximal lateral, thus, can
To read the blood pressure readings of narrow remote end and narrow width proximal in the case of not moving medical guiding wire 2.Thereby, it is possible to reduce intervention
The operation complexity for the treatment of and saving operating time.
Fig. 7 is the schematic cross-section of the blood vessel of intravascular pressure measurement conduit involved by embodiments of the present invention.Fig. 8
Blood pressure measurement conduit involved by embodiments of the present invention along length of vessel direction schematic section.
In fig. 7 it is shown that the schematic cross-section that blood pressure measurement conduit 1 moves in intravascular.As shown in fig. 7, medical
Seal wire 2 is placed complete in the case of, blood pressure measurement conduit 1 can move in intravascular along medical guiding wire 2, thus convenient
To the given stenosis navigating to patient.
In fig. 8 it is shown that narrow schematic diagram in the blood vessel 100 of patient.As shown in figure 8, the blood vessel in blood vessel 100
Speckle 110 is formed with inwall, it is narrow that the formation of speckle 110 leads to this part blood vessel to present under X-ray.Here, blood vessel 100
Blood flow flow to the far-end 100a of blood vessel 100 from the near-end 100b of blood vessel 100 along blood flow direction D.
FFR in order to carry out this narrow blood vessel measures, and doctor waits, by operation, blood pressure measurement conduit 1 is placed in narrow blood vessel
The distal side 100a (i.e. near the downstream of blood flow) of (such as coronary artery) 100.Now, pressure transducer 40 be located at narrow remote
Distal side (downstream) at the 100a of side, records the blood pressure Pd of distal side.Then, pressure transducer 40 is placed in narrow position
The blood pressure Pp of proximal lateral (i.e. the upstream of blood flow, such as near the aorta) 100b of (such as stenotic lesion 110).FFR can change
Letter is the ratio that remote pressure is with respect to proximal pressure, i.e. FFR=Pd/Pp.In the present embodiment, term " downstream " and " on
Trip " is for the normal direction " D " (referring to Fig. 8) of blood flow.
Although the above-mentioned intravascular pressure measurement conduit 1 that describe in detail involved by embodiments of the present invention, this
Invention is not limited to above-mentioned embodiment.For example, in certain embodiments, can be multiple along the sidepiece setting of distal cannula 10
Perforate (not shown).The setting of perforate can reduce the probability of the blocking in outer tube 30 (including distal cannula 10).For example, when
When blood pressure measurement conduit 1 is moved through tremulous pulse, speckle 110 of blood vessel wall etc. is possible to enter outer tube 30, in the side of outer tube 30
It is provided with perforate in portion and can suppress this effect.
Hereinafter, with reference to Fig. 9, the intravascular pressure involved by description embodiments of the present invention measures the user of conduit
Method.
The intravascular pressure that Fig. 9 shows involved by embodiments of the present invention measures the flow process of the using method of conduit
Figure.When using blood pressure measurement conduit 1, first, from certain position of patient, medical guiding wire 2 is placed into body by such as thigh tremulous pulse
Interior precalculated position (step S10).Then, on medical guiding wire 2 configuration blood pressure measurement conduit 1 (that is, by medical guiding wire 2 through
The guidewire lumen 12 of blood pressure measurement conduit 1), and by blood pressure measurement conduit 1 along medical guiding wire 2 (for example by other guiding
Conduit (not shown)) enter at the stenotic lesion of human vas 100 so that the pressure transducer 40 on blood pressure measurement conduit 1 is fixed
Vicinity (for example, the upstream of stenotic lesion or downstream) (step S20) positioned at above-mentioned precalculated position.In certain embodiments, exist
Distal cannula 10 is made to slide along medical guiding wire 2 and advance distal cannula 10 in the case of not needing mobile medical guiding wire 2.
The blood in this pre-position downstream in step S20, is measured using the pressure transducer 40 of blood pressure measurement conduit 1
Pressure (i.e. the blood pressure Pd of distal side 100a).Then it is not necessary to reorientate the position of medical guiding wire 2, by adjusting blood pressure measurement
The position of conduit 1, blood pressure measurement conduit 1 is moved to the upstream of stenotic lesion, and the blood pressure Pp of measurement stenotic lesion upstream is (i.e. near
The blood pressure Pp of side 100b) (step S30).Blood pressure signal (the blood pressure Pd of distal side and near produced by pressure transducer 40
The blood pressure Pp of side) it is output to for example external processing equipment (not shown) via signal path 22.In addition, reason sets in this place
In standby, the ratio that can calculate this two measured values is downstream blood pressure to the ratio Pd/Pp of upstream blood pressure as FFR value, that is,
FFR=Pd/Pp (step S40).
Although being illustrated to the present invention above in association with drawings and embodiments, it is not intended to limit
The present invention it will be appreciated that to those skilled in the art, without departing from the spirit and scope of the present invention, can
To be deformed to the present invention and to change, these deformation and change each fall within the scope of the claimed protection of the present invention.
Claims (10)
1. a kind of intravascular pressure measurement conduit it is characterised in that：
Including：
Distal cannula, it has the guidewire lumen slideably received within single medical guiding wire；
Pressure transducer, it is arranged on the outside of described distal cannula, for measuring endovascular blood pressure and producing blood pressure signal；
And
Proximal part, it is coupled with described distal cannula, and includes the described blood from described pressure transducer for transmission
The signal path of pressure signal and the connecting conduit for supporting described signal path mobile described distal cannula,
In the front end of described distal cannula, it is provided with the ring-shaped sleeve as positioning mark,
Described ring-shaped sleeve has pliability and comprises the opaque material to X-ray.
2. intravascular pressure as claimed in claim 1 measurement conduit it is characterised in that：
It is also equipped with coating the outer tube of described distal cannula and described pressure transducer.
3. intravascular pressure as claimed in claim 2 measurement conduit it is characterised in that：
Described distal cannula is coupled via described outer tube with described proximal part.
4. as described in any one of claims 1 to 3 intravascular pressure measurement conduit it is characterised in that：
Described guidewire lumen is slideably received within the medical guiding wire with external diameter about 0.2mm to 1mm.
5. intravascular pressure as claimed in claim 3 measurement conduit it is characterised in that：
Described guidewire lumen includes tubular inner chamber and in the bending of the side that described tubular inner chamber extends to described outer tube
Chamber.
6. as described in any one of claims 1 to 3 intravascular pressure measurement conduit it is characterised in that：
Described pressure transducer is arranged on the outer surface of described distal cannula, and near described ring-shaped sleeve.
7. as described in any one of claims 1 to 3 intravascular pressure measurement conduit it is characterised in that：
Described distal cannula has the perforate of the length direction along described distal cannula,
Described perforate allows blood flow to flow into described guidewire lumen.
8. intravascular pressure as claimed in claim 2 or claim 3 measurement conduit it is characterised in that：
Described outer tube has the opening allowing described pressure transducer to measure blood pressure.
9. intravascular pressure as claimed in claim 1 measurement conduit it is characterised in that：
Described signal path is at least partially recessed in described connecting conduit.
10. intravascular pressure as claimed in claim 1 measurement conduit it is characterised in that：
Described distal cannula is coaxial with described ring-shaped sleeve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610911057.6A CN106388800A (en) | 2016-02-19 | 2016-02-19 | Catheter capable of measuring pressure in blood vessel |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610911057.6A CN106388800A (en) | 2016-02-19 | 2016-02-19 | Catheter capable of measuring pressure in blood vessel |
| CN201610095320.9A CN105769153A (en) | 2016-02-19 | 2016-02-19 | Endovascular pressure measurement conduit |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610095320.9A Division CN105769153A (en) | 2016-02-19 | 2016-02-19 | Endovascular pressure measurement conduit |
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| CN106388800A true CN106388800A (en) | 2017-02-15 |
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| CN201610911057.6A Pending CN106388800A (en) | 2016-02-19 | 2016-02-19 | Catheter capable of measuring pressure in blood vessel |
| CN201610095320.9A Pending CN105769153A (en) | 2016-02-19 | 2016-02-19 | Endovascular pressure measurement conduit |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201610095320.9A Pending CN105769153A (en) | 2016-02-19 | 2016-02-19 | Endovascular pressure measurement conduit |
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| CN107569223A (en) * | 2017-10-21 | 2018-01-12 | 深圳北芯生命科技有限公司 | Intravascular pressure measurement conduit with developing ring |
| CN108618768A (en) * | 2017-03-15 | 2018-10-09 | 深圳北芯生命科技有限公司 | Intravascular pressure with mounting base measures conduit |
| WO2020093967A1 (en) * | 2018-11-05 | 2020-05-14 | 苏州润迈德医疗科技有限公司 | Novel catheter for invasive arterial pressure monitoring, and method for using same |
| WO2021134868A1 (en) * | 2019-12-31 | 2021-07-08 | 深圳北芯生命科技有限公司 | Intravascular pressure measurement system |
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| CN107320068B (en) * | 2017-06-12 | 2020-10-16 | 长飞光纤光缆股份有限公司 | Manufacturing method of interventional probe body |
| CN107736884B (en) * | 2017-10-19 | 2018-10-12 | 深圳北芯生命科技有限公司 | Intravascular pressure with supporting mechanism measures conduit |
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| CN112336328B (en) * | 2019-08-07 | 2022-09-30 | 深圳北芯生命科技股份有限公司 | Intravascular pressure measuring catheter with developing ring |
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|---|---|
| CN105769153A (en) | 2016-07-20 |
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