CN106361730A - New uses of pentafluoropropane as medical condensing agent in local anesthesia, pain stopping and swelling subsiding - Google Patents
New uses of pentafluoropropane as medical condensing agent in local anesthesia, pain stopping and swelling subsiding Download PDFInfo
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- CN106361730A CN106361730A CN201510435392.9A CN201510435392A CN106361730A CN 106361730 A CN106361730 A CN 106361730A CN 201510435392 A CN201510435392 A CN 201510435392A CN 106361730 A CN106361730 A CN 106361730A
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- spray
- pentafluoropropane
- tetrafluoroethane
- local anesthesia
- medical
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Abstract
The invention relates to a fluoroalkane-containing spray or injection, wherein the preparation method comprises: loading fluoroalkane such as tetrafluoroethane, pentafluoropropane or a combination thereof, and an ethanol solvent and/or a pharmaceutically active ingredient into a pressurizable metal container according to a certain ratio to form a sprayable preparation so as to prepare the product. According to the present invention, with the product, the local anesthesia before slight operations can be achieved, and various acute closed injuries during exercise can be reduced or eliminated.
Description
Technical field
The present invention relates to pentafluoropropane as medical condensing agent in terms of local anesthesia, pain relieving and detumescence
New application, belongs to the research and development field of medical preparation.
Background technology
In pharmaceutical preparation, aerosol is usually used in treating relevant respiratory system disease, by oral cavity, nose
The administering modes such as chamber are sucked or spray delivery, reach effective treatment.In prior art, report
The application as spray for the ethyl chloride, but ethyl chloride inflammable and explosive safety is constituted potential threaten,
Ethyl chloride damages the ozone layer after entering atmosphere simultaneously, and atmospheric environment and environment for human survival are caused brokenly
Bad, World Health Organization's explicit order regulation time limit is stopped using, and this product will be died.
With the attention to environmental problem, people adopt more environmentally-friendly fluoride as spray point
Powder.Such as tetrafluoroethane, heptafluoro-propane etc., but these fluorides are high to equipment requirements, canned fill
When filling out, degree of accuracy is difficult to ensure that, the defect such as fill vapour pressure is non-adjustable.Chinese patent cn1778390a
Disclose and pentafluoropropane is used as aerosol dispersion agent, solve the problems, such as that tank pressure is too high explosive.It is public
The aerosol opened is administered for inhalation route, with therapy-related disease, and fluoroalkane is used for wink
Between the spray of the function such as pain relieving, detumescence have not been reported.
Pentafluoropropane is a kind of water white transparency mobile liquid, has a volatility, 15.3 DEG C of boiling point,
Stable under normal temperature and pressure, it is mainly used in refrigerator, the foaming of slabstock polyurethane adiabator etc..Main usess
It is foaming agent, cleaning agent, cold-producing medium, low boiling point solvent etc..Tetrafluoroethane is a kind of using the most extensive
Middle low-temperature environment-friendly cold-producing medium, there is good combination property, be widely used as air conditioning for automobiles, refrigerator,
The cold-producing medium of the industries such as commercial refrigeration, and can be used for medicine, pesticide, cosmetics, cleaning industry.
Content of the invention
The present invention provide a kind of spray containing fluoric ether, its can be used for local quickly alleviating pain, detumescence,
Anesthesia, sterilization, can be used for preoperative pain relieving with injection form.For example slight handss are realized by injection
Preoperative local anesthesia, is mitigated or eliminated various acute closed property in motion by spraying and damages (muscle
Pull, dampen, soft tissue of joint bruise, fracture, replace dislocated joints).
The present invention is achieved through the following technical solutions:
There is provided a kind of spray, it comprises fluoric ether and ethanol solution, and wherein fluoric ether is four
Fluoroethane, pentafluoropropane or a combination thereof.
Preferably, in described spray, ethanol solution accounts for the 40%-75% of spray cumulative volume.
When described fluoric ether mixes composition for tetrafluoroethane with pentafluoropropane, pentafluoropropane volume fraction
For 70%-99%, tetrafluoroethane volume fraction is 30%-1%.
Preferably, also comprise in described spray the detumescence of effective dose, anesthesia, sterilization, in analgesic
One or more." effective dose " is defined as the permeation flux of selected medicine in this area, and it will foot
The medicine delivery of enough amounts to skin or passes through skin, to reach the effect of clinical benefit.
It is furthermore preferred that described detumescence, anesthesia, sterilization, analgesic be selected from Radix Et Rhizoma Rhei, Borneolum Syntheticum, Radix Notoginseng,
One or more of azone, diclofenac sodium.
Preferably, described spray cumulative volume is 10-250ml.
Additionally, the present invention also provides a kind of injection, its constituent is identical with above-mentioned spray.
Using method: above-mentioned solution is loaded in a canister that can pressurize, simultaneously away from affected part
3-5cm, holds aerosol apparatus, press push button, sprays the 3-10 second, 1-3 time on the one or determined according to traumatic condition
Surely spray number of times.
Injection uses in the preoperative.
The method have the advantages that
1. do not fire not quick-fried it is easy to transporting, storing, no potential safety hazard；
2. easy to use, onset is rapid；
3. do not damage the ozone layer, environmental friendliness；
4. raw material is easy to get, and product price is cheap；
5. pain relieving, detumescence, antiinflammatory, anaesthetic effect are excellent.
Specific embodiment
Embodiment 1 tetrafluoroethene+ethanol solution
By tetrafluoroethane, ethanol solution and active constituents of medicine according to said ratio, loading one can add
In the canister of pressure, form sprayable preparation, obtain final product.Injection proportioning forms phase with this spray
With it can choose suitable consumption as needed.
Embodiment 2 tetrafluoroethene+ethanol solution
By pentafluoropropane, ethanol solution and active constituents of medicine according to said ratio, loading one can add
In the canister of pressure, form sprayable preparation, obtain final product.Injection proportioning forms phase with this spray
With it can choose suitable consumption as needed.
Embodiment 3 tetrafluoroethane+pentafluoropropane+ethanol solution
By pentafluoropropane, tetrafluoroethane, ethanol solution and active constituents of medicine according to said ratio, fill
Enter in a canister that can pressurize, form sprayable preparation, obtain final product.Injection proportioning is sprayed with this
Mist agent composition is identical, and it can choose suitable consumption as needed.
Embodiment 4
By spray arbitrary described in embodiment 1-3 from prelum be ejected into this needs have damage or
The position swollen and ache, sprays the 3-10 second, or depending on degree of impairment.Spray connects with as use rapidly
Place, pain is eased, and after 1-2 hour, has this position situation needing to be clearly better.One day
Interior, can apply 1-3 time, quick elimination is damaged or pain.
Claims (7)
1. a kind of fluoric ether spray it is characterised in that: comprise fluoric ether and ethanol solution,
Wherein fluoric ether be tetrafluoroethane, pentafluoropropane or its mixing.
2. spray as claimed in claim 1, wherein ethanol solution account for spray cumulative volume
40%-75%.
3. spray as claimed in claim 2, wherein fluoric ether are tetrafluoroethane and pentafluoropropane
Mixing composition, and pentafluoropropane volume fraction is 70%-99%, tetrafluoroethane volume fraction is
30%-1%.
4. spray as described in any one of claim 2-3, its also comprise effective dose for subsiding a swelling,
Anesthesia, sterilization, the active constituents of medicine of pain relieving.
5. spray as claimed in claim 4, its described active constituents of medicine is selected from: Radix Et Rhizoma Rhei, ice
One or more of piece, Radix Notoginseng, azone, diclofenac sodium.
6. spray as described in any one of claim 1-5, wherein spray cumulative volume are 10-250ml.
7. spray as described in any one of claim 1-6, it is alternatively arranged as injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510435392.9A CN106361730A (en) | 2015-07-23 | 2015-07-23 | New uses of pentafluoropropane as medical condensing agent in local anesthesia, pain stopping and swelling subsiding |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510435392.9A CN106361730A (en) | 2015-07-23 | 2015-07-23 | New uses of pentafluoropropane as medical condensing agent in local anesthesia, pain stopping and swelling subsiding |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106361730A true CN106361730A (en) | 2017-02-01 |
Family
ID=57880216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510435392.9A Pending CN106361730A (en) | 2015-07-23 | 2015-07-23 | New uses of pentafluoropropane as medical condensing agent in local anesthesia, pain stopping and swelling subsiding |
Country Status (1)
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| CN (1) | CN106361730A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111297802A (en) * | 2018-12-12 | 2020-06-19 | 成都一平医药科技发展有限公司 | Anti-inflammatory and antibacterial composition |
| CN113712921A (en) * | 2021-09-02 | 2021-11-30 | 沈阳德隆医疗器械有限公司 | Novel rapid local pain-relieving hemostatic and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6235265B1 (en) * | 1998-10-28 | 2001-05-22 | Alliedsignal Inc. | Evaporative coolant for topical anesthesia comprising hydrofluorocarbons and/or hydrochlorofluorocarbons |
| US6737041B1 (en) * | 1993-08-20 | 2004-05-18 | University Of Cincinnati | Non-ozone depleting vapocoolants |
| CN101165135A (en) * | 2006-10-17 | 2008-04-23 | 浙江莹光化工有限公司 | Non-combustible aerosol composition |
| CN103446052A (en) * | 2013-09-09 | 2013-12-18 | 马北峰 | Aerosol for treating micro-trauma of human body and using method thereof |
-
2015
- 2015-07-23 CN CN201510435392.9A patent/CN106361730A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6737041B1 (en) * | 1993-08-20 | 2004-05-18 | University Of Cincinnati | Non-ozone depleting vapocoolants |
| US6235265B1 (en) * | 1998-10-28 | 2001-05-22 | Alliedsignal Inc. | Evaporative coolant for topical anesthesia comprising hydrofluorocarbons and/or hydrochlorofluorocarbons |
| CN101165135A (en) * | 2006-10-17 | 2008-04-23 | 浙江莹光化工有限公司 | Non-combustible aerosol composition |
| CN103446052A (en) * | 2013-09-09 | 2013-12-18 | 马北峰 | Aerosol for treating micro-trauma of human body and using method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111297802A (en) * | 2018-12-12 | 2020-06-19 | 成都一平医药科技发展有限公司 | Anti-inflammatory and antibacterial composition |
| CN113712921A (en) * | 2021-09-02 | 2021-11-30 | 沈阳德隆医疗器械有限公司 | Novel rapid local pain-relieving hemostatic and application thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170201 |
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| RJ01 | Rejection of invention patent application after publication |