CN106310361B - A kind of preparation method for promoting wound to repair bearing hydrocolloid dressing - Google Patents
A kind of preparation method for promoting wound to repair bearing hydrocolloid dressing Download PDFInfo
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
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Abstract
The invention discloses the preparation methods that a kind of promotion wound repairs bearing hydrocolloid dressing, belong to medical dressing preparation technical field.AFGF freeze-dried powder is added in gelatin and carboxymethyl chitosan mixed liquor the present invention, the transparent liquid of AFGF must be loaded, by itself and sodium carboxymethylcellulose, the lysate of the substances such as apple pectin mixes, crosslinking agent is added after sonic oscillation, cross-linking reaction is carried out at a certain temperature, mix to obtain spinning solution with resin viscous fluid after reaction solution, load AFGF fiber is made using wet spinning, and with pure cotton fiber mixed textile at cloth, the present invention passes through addition apple pectin, it improves the water suction duration of dressing and accelerates gel, pass through addition styrene-isoprene block copolymer again, effectively improve the viscosity and peel strength of dressing, and hydrocolloid preparation is woven into cloth by the present invention, without film matrix, solve the problems, such as that binding force is weak between hydrocolloid and thin polymer film, the extensive of wound can be effectively facilitated It is multiple, it has broad application prospects.
Description
Technical field
The invention discloses the preparation methods that a kind of promotion wound repairs bearing hydrocolloid dressing, belong to medical dressing technology of preparing
Field.
Background technique
Human skin can not only make one homoiostasis, while can also prevent the invasion of bacterium, microorganism.Work as skin
When skin injury, under conditions of homeostasis is broken, medical dressing can give human body as a kind of medical material that cures the wound
Certain necessary protection, reduces the extent of injury.Before skin recovery, good medical dressing temporary can play a part
Skin blocks the effect of function, provides advantageous condition for the healing of wound.
Medical use hydrocolloid dressing is that hydrocolloid particle and rubber substrate are mixed to a kind of rear made medical material.It is this
Material had not only had the water absorbing properties of hydrocolloid particle simultaneously but also had had the bond properties of rubber substrate.Rubber substrate makes with viscosity
Dressing is fitted on wound, is swollen after hydrocolloid particle water suction, is provided a wet healing environment to wound, can be promoted to hurt
The healing of mouth.This dressing because can maintain wet healing environment for a long time on wound, to the tourniquet of wound
To greatly facilitate.Medical use hydrocolloid dressing can also fully absorb the diffusate on wound, provide physics for wound
Bacterium infection wound is prevented while protective effect.Medical use hydrocolloid dressing viscosity decline after moisture absorption is easy to from wound surface
It removes and hardly patient is allowed to feel pain during removal.
Traditional bearing hydrocolloid dressing is by having sticking polymeric substrates and water-soluble polymer beads, such as pectin, bright
Glue and carboxymethyl cellulose etc. are formed, or polymer film is squeezed out in advance in release paper or other base materials, then
It is compound therewith when squeezing out hydrocolloid layer, release paper or other base materials are removed immediately.But traditional bearing hydrocolloid dressing
Since the hydrocolloid particle in dressing and the binding force between thin polymer film be not strong after film forming, when bearing hydrocolloid dressing is exposed to corruption
When under corrosion fluid, they are easy to be destroyed, and when these compositions are used as skin barrier, can absorb parameatal stream
Body, after absorbing fluid, the hydrocolloid being dispersed in rubber can be swollen, and swelling makes dressing lose integrality.Lose integrality
Skin barrier easily causes fluid to leak, and dressing needs frequent replacement, and residuals frequently stay on the skin.
Summary of the invention
Present invention mainly solves the technical issues of: for hydrocolloid particle and thin polymer film in existing bearing hydrocolloid dressing
Between binding force it is not strong, dressing water absorption is smaller, swellability is poor, cause dressing that the defect of fluid leakage and peeling easily occurs,
The present invention provides a kind of mixed using load reparation wound factor hydroaropic substance with rubber elastomer to carry out spinning, obtains fiber
Woven fabric is mixed with cotton fiber afterwards, can be obtained and wound is promoted to repair bearing hydrocolloid dressing, the present invention first aFGF freeze-dried powder is added bright
In glue and carboxymethyl chitosan mixed liquor, the transparent liquid of aFGF must be loaded, by the objects such as itself and sodium carboxymethylcellulose, apple pectin
The lysate of matter mixes, and crosslinking agent is added after sonic oscillation, carries out cross-linking reaction at a certain temperature, obtain after reaction solution with resin
Viscous fluid mixes to obtain spinning solution, using must load aFGF fiber after wet spinning, and with pure cotton fiber mixed textile at cloth,
The present invention improves the water suction duration of dressing and accelerates gel by addition apple pectin, then passes through addition styrene-
Isoprene block copolymer effectively improves the viscosity and peel strength of dressing, and hydrocolloid preparation is woven by the present invention
Cloth does not need film matrix, solves the problems, such as that the binding force between hydrocolloid and thin polymer film is not strong, can effectively facilitate wound
Recovery, have broad application prospects.
In order to solve the above-mentioned technical problem, the technical scheme adopted by the invention is that:
(1) 20~30g gelatin is weighed respectively and 10~15g carboxymethyl chitosan is put into beaker, addition 400~
1~2h of mechanical stirring after 500mL deionized water, is warming up to 35~37 DEG C after mixing evenly, 3 is added at this temperature
~5gaFGF freeze-dried powder, continues to be stirred 1~2h, must load the transparent liquid of aFGF；
(2) weigh respectively 20~30g sodium carboxymethylcellulose, 5~10g apple pectin, 5~10g snail mucus and
10~15g sodium alginate is added in 400~500mL deionized water, is stirred rear saturating with above-mentioned load aFGF
Bright liquid mixing, uses sonic oscillation instrument 10~15min of sonic oscillation under 220~250W power, is heated to 55 after oscillation after mixing
~65 DEG C, 3~5mL mass fraction, 1% glutaraldehyde solution and 1~3mL mass fraction, 0.1% hydrochloric acid solution are added at this temperature,
3~5h of insulation reaction obtains reaction solution after stirring；
(3) 100~120g styrene-isoprene block copolymer is weighed to be added in reaction kettle, it is heated to 140~
160 DEG C, 20~40g terpene resin is added to melting in stirring after fusing, continuation insulated and stirred mixes 1~2h and must set
Rouge viscous fluid mixes resin viscous fluid and above-mentioned reaction solution 1:5 in mass ratio, and spinning solution is obtained after being uniformly mixed；
It (4) is that 3~5m/min is squeezed out from spinneret with extruded velocity by above-mentioned spinning solution, the spinning leaching after extrusion
Enter and be frozen into tow in 10~20 DEG C of deionized water, load can be obtained in the tow freeze-drying after solidification
AFGF fiber；
(5) pure cotton fiber and above-mentioned load aFGF fiber are carried out by 1:10 radical into stock, at blended at line after stock, is used in combination
Loom is woven into gauze, and gauze is cut according to the size of 50mm × 50mm, 10~12h is freezed under the conditions of -10~-5 DEG C,
Thaw 5~7h at room temperature after freezing, packs after defrosting, can be obtained and wound is promoted to repair bearing hydrocolloid dressing.
Application method of the invention is: promotion wound produced by the present invention reparation bearing hydrocolloid dressing is attached to pressure sore wound table
Face, and dressing is made to be fitted tightly over skin surface, it then daily change dressings 1 time, when wound exudate amount is few, was then changed every 3~5 days
Dressing 1 time, until wound healing.Through detecting, bearing hydrocolloid dressing peel strength produced by the present invention is 0.3~0.6N/mm, for 24 hours
Water absorption is up to 4500~8000g/m2, swellability be 220~350%, dressing integrality up to 85~93%, there is preferable swellability
With integrality and water absorption appropriate, and using bearing hydrocolloid dressing of the present invention treatment after healing time compared with traditional dressing shortening
40~50%, it can preferably protect wound and promote the healing of wound.
The beneficial effects of the present invention are:
(1) bearing hydrocolloid dressing produced by the present invention can effectively absorb the fester of wound exudation, can reduce the replacement time of dressing
Number, while wound healing can be promoted, it can be applied to the treatment of a variety of different wounds, have particularly with chronic refractory wound aobvious
Write curative effect；
(2) bearing hydrocolloid dressing water absorption of the present invention is appropriate and good peel strength, and initial bonding strength and holding power are stronger, so that
Dressing can be fitted tightly over wound, while can be effectively peeled off adherend body, and will not be that a kind of ideal wound is deposited there are residue glue
Material.
Specific embodiment
It weighs 20~30g gelatin respectively first and 10~15g carboxymethyl chitosan is put into beaker, addition 400~
1~2h of mechanical stirring after 500mL deionized water, is warming up to 35~37 DEG C after mixing evenly, 3 is added at this temperature
~5gaFGF freeze-dried powder, continues to be stirred 1~2h, must load the transparent liquid of aFGF；20~30g carboxymethyl is then weighed respectively
400~500mL deionized water is added in sodium cellulosate, 5~10g apple pectin, 5~10g snail mucus and 10~15g sodium alginate
In, it is stirred the rear transparent liquid with above-mentioned load aFGF and mixes, surpassed under 220~250W power after mixing with sonic oscillation instrument
10~15min of sound oscillation is heated to 55~65 DEG C after oscillation, 3~5mL mass fraction, 1% glutaraldehyde solution is added at this temperature
With 1~3mL mass fraction, 0.1% hydrochloric acid solution, 3~5h of insulation reaction obtains reaction solution after stirring；100~120g benzene second is weighed again
Alkene-isoprene block copolymer is added in reaction kettle, is heated to 140~160 DEG C, stirring to melting, be added 20 after fusing~
40g terpene resin continues 1~2h of insulated and stirred mixing and obtains resin viscous fluid, resin viscous fluid and above-mentioned reaction solution are pressed quality
It is mixed than 1:5, spinning solution is obtained after being uniformly mixed；It is again 3~5m/min from spinneret with extruded velocity by above-mentioned spinning solution
Middle extrusion, the spinning after extrusion, which is immersed in 10~20 DEG C of deionized water, is frozen into tow, the tow freeze-drying after solidification, i.e.,
It can obtain load aFGF fiber；Finally pure cotton fiber and above-mentioned load aFGF fiber are carried out at stock, after stock by 1:10 radical
It is blended to be woven into gauze at line, and with loom, gauze is cut according to the size of 50mm × 50mm, in -10~-5 DEG C of conditions
10~12h of lower freezing, thaw 5~7h at room temperature after freezing, packs after defrosting, can be obtained and wound reparation hydrocolloid is promoted to apply
Material.
Example 1
It weighs 20g gelatin respectively first and 10g carboxymethyl chitosan is put into beaker, machine after 400mL deionized water is added
Tool stirs 1h, is warming up to 35 DEG C after mixing evenly, and 3gaFGF freeze-dried powder is added at this temperature, continues to be stirred 1h, obtain negative
Carry the transparent liquid of aFGF；20g sodium carboxymethylcellulose, 5g apple pectin, 5g snail mucus and 10g alginic acid are then weighed respectively
Sodium is added in 400mL deionized water, is stirred the rear transparent liquid with above-mentioned load aFGF and mixes, and sonic oscillation instrument is used after mixing
The sonic oscillation 10min under 220W power, is heated to 55 DEG C after oscillation, 1% glutaraldehyde of 3mL mass fraction is added at this temperature
0.1% hydrochloric acid solution of solution and 1mL mass fraction, insulation reaction 3h obtain reaction solution after stirring；100g styrene-isoamyl is weighed again
Diene block copolymer is added in reaction kettle, is heated to 140 DEG C, and 20g terpene resin is added to melting in stirring after fusing, continue
Insulated and stirred mixing 1h obtains resin viscous fluid, and resin viscous fluid and above-mentioned reaction solution 1:5 in mass ratio are mixed, are stirred
Spinning solution is obtained after even；It is again that 3m/min is squeezed out from spinneret with extruded velocity by above-mentioned spinning solution, the spinning after extrusion is immersed
Tow is frozen into 10 DEG C of deionized water, load aFGF fiber can be obtained in the tow freeze-drying after solidification；It finally will be pure
Cotton fiber and above-mentioned load aFGF fiber are carried out by 1:10 radical into stock, are weaved resultant yarn at blended at line after stock, and with loom
Gauze is cut according to the size of 50mm × 50mm, 10h is freezed under the conditions of -10 DEG C by cloth, and thaw 5h at room temperature after freezing,
It is packed after defrosting, can be obtained and wound is promoted to repair bearing hydrocolloid dressing.
This example operation is easy, in use, promotion wound produced by the present invention reparation bearing hydrocolloid dressing is attached to pressure sore wound
Discharge surface, and dressing is made to be fitted tightly over skin surface, then daily change dressings 1 time, when wound exudate amount is few, then every 3 days
Change dressings 1 time, until wound healing.Through detecting, bearing hydrocolloid dressing peel strength produced by the present invention is 0.3N/mm, is absorbed water for 24 hours
Amount reaches 4500g/m2, swellability 220%, after dressing water suction integrality up to 85%, have preferable swellability and integrality and
Water absorption appropriate, and shorten 400% compared with traditional dressing using the healing time after bearing hydrocolloid dressing of the present invention treatment, it can be preferably
Protection wound and promote wound healing.
Example 2
It weighs 25g gelatin respectively first and 13g carboxymethyl chitosan is put into beaker, machine after 450mL deionized water is added
Tool stirs 1h, is warming up to 36 DEG C after mixing evenly, and 4gaFGF freeze-dried powder is added at this temperature, continues to be stirred 1h, obtain negative
Carry the transparent liquid of aFGF；25g sodium carboxymethylcellulose, 8g apple pectin, 8g snail mucus and 13g alginic acid are then weighed respectively
Sodium is added in 450mL deionized water, is stirred the rear transparent liquid with above-mentioned load aFGF and mixes, and sonic oscillation instrument is used after mixing
The sonic oscillation 13min under 235W power, is heated to 60 DEG C after oscillation, 1% glutaraldehyde of 4mL mass fraction is added at this temperature
0.1% hydrochloric acid solution of solution and 2mL mass fraction, insulation reaction 4h obtain reaction solution after stirring；110g styrene-isoamyl is weighed again
Diene block copolymer is added in reaction kettle, is heated to 150 DEG C, and 30g terpene resin is added to melting in stirring after fusing, continue
Insulated and stirred mixing 1h obtains resin viscous fluid, and resin viscous fluid and above-mentioned reaction solution 1:5 in mass ratio are mixed, are stirred
Spinning solution is obtained after even；It is again that 4m/min is squeezed out from spinneret with extruded velocity by above-mentioned spinning solution, the spinning after extrusion is immersed
Tow is frozen into 15 DEG C of deionized water, load aFGF fiber can be obtained in the tow freeze-drying after solidification；It finally will be pure
Cotton fiber and above-mentioned load aFGF fiber are carried out by 1:10 radical into stock, are weaved resultant yarn at blended at line after stock, and with loom
Gauze is cut according to the size of 50mm × 50mm, 11h is freezed under the conditions of -8 DEG C, thaw 6h at room temperature after freezing, solution by cloth
It is packed after jelly, can be obtained and wound is promoted to repair bearing hydrocolloid dressing.
This example operation is easy, in use, promotion wound produced by the present invention reparation bearing hydrocolloid dressing is attached to pressure sore wound
Discharge surface, and dressing is made to be fitted tightly over skin surface, then daily change dressings 1 time, when wound exudate amount is few, then every 4 days
Change dressings 1 time, until wound healing.Through detecting, bearing hydrocolloid dressing peel strength produced by the present invention is 0.4N/mm, is absorbed water for 24 hours
Amount reaches 6200g/m2, swellability 280%, after dressing water suction integrality up to 89%, have preferable swellability and integrality and
Water absorption appropriate, and shorten 45% compared with traditional dressing using the healing time after bearing hydrocolloid dressing of the present invention treatment, it can be preferable
It protects wound and promotes the healing of wound.
Example 3
It weighs 30g gelatin respectively first and 15g carboxymethyl chitosan is put into beaker, machine after 500mL deionized water is added
Tool stirs 2h, is warming up to 37 DEG C after mixing evenly, and 5gaFGF freeze-dried powder is added at this temperature, continues to be stirred 2h, obtain negative
Carry the transparent liquid of aFGF；30g sodium carboxymethylcellulose, 10g apple pectin, 10g snail mucus and 15g seaweed are then weighed respectively
Sour sodium is added in 500mL deionized water, is stirred the rear transparent liquid with above-mentioned load aFGF and mixes, sonic oscillation is used after mixing
Instrument sonic oscillation 15min under 250W power, is heated to 65 DEG C after oscillation, 5mL mass fraction 1% penta 2 is added at this temperature
0.1% hydrochloric acid solution of aldehyde solution and 3mL mass fraction, insulation reaction 5h obtain reaction solution after stirring；It is different that 120g styrene-is weighed again
Pentadiene block copolymer is added in reaction kettle, is heated to 160 DEG C, and 40g terpene resin is added to melting in stirring after fusing, after
Continuation of insurance temperature is stirred 2h and obtains resin viscous fluid, and resin viscous fluid and above-mentioned reaction solution 1:5 in mass ratio are mixed, are stirred
Spinning solution is obtained after uniformly；It is again that 5m/min is squeezed out from spinneret with extruded velocity by above-mentioned spinning solution, the spinning leaching after extrusion
Enter and be frozen into tow in 20 DEG C of deionized water, load aFGF fiber can be obtained in the tow freeze-drying after solidification；Finally will
Pure cotton fiber and above-mentioned load aFGF fiber are carried out by 1:10 radical into stock, at blended at line after stock, and are woven into loom
Gauze is cut according to the size of 50mm × 50mm, 12h is freezed under the conditions of -5 DEG C by gauze, and thaw 7h at room temperature after freezing,
It is packed after defrosting, can be obtained and wound is promoted to repair bearing hydrocolloid dressing.
This example operation is easy, in use, promotion wound produced by the present invention reparation bearing hydrocolloid dressing is attached to pressure sore wound
Discharge surface, and dressing is made to be fitted tightly over skin surface, then daily change dressings 1 time, when wound exudate amount is few, then every 5 days
Change dressings 1 time, until wound healing.Through detecting, bearing hydrocolloid dressing peel strength produced by the present invention is 0.6N/mm, is absorbed water for 24 hours
Amount reaches 8000g/m2, swellability 350%, after dressing water suction integrality up to 93%, have preferable swellability and integrality and
Water absorption appropriate, and shorten 50% compared with traditional dressing using the healing time after bearing hydrocolloid dressing of the present invention treatment, it can be preferable
It protects wound and promotes the healing of wound.
Claims (1)
1. a kind of preparation method for promoting wound to repair bearing hydrocolloid dressing, it is characterised in that specific preparation step are as follows:
(1) 20~30g gelatin is weighed respectively and 10~15g carboxymethyl chitosan is put into beaker, addition 400~
1~2h of mechanical stirring after 500mL deionized water, is warming up to 35~37 DEG C after mixing evenly, at this temperature be added 3~
5gaFGF freeze-dried powder continues to be stirred 1~2h, must load the transparent liquid of aFGF；
(2) weigh respectively 20~30g sodium carboxymethylcellulose, 5~10g apple pectin, 5~10g snail mucus and
10~15g sodium alginate is added in 400~500mL deionized water, is stirred rear and above-mentioned load aFGF transparent liquid
Mixing uses sonic oscillation instrument 10~15min of sonic oscillation under 220~250W power, is heated to 55~65 after oscillation after mixing
DEG C, 3~5mL mass fraction, 1% glutaraldehyde solution and 1~3mL mass fraction, 0.1% hydrochloric acid solution, heat preservation are added at this temperature
3~5h is reacted, reaction solution is obtained after stirring；
(3) 100~120g styrene-isoprene block copolymer is weighed to be added in reaction kettle, it is heated to 140~
It 160 DEG C, stirs to melting, 20~40g terpene resin is added after fusing, it is viscous that 1~2h of continuation insulated and stirred mixing obtains resin
Magma mixes resin viscous fluid and above-mentioned reaction solution 1:5 in mass ratio, and spinning solution is obtained after being uniformly mixed；
It (4) is that 3~5m/min is squeezed out from spinneret with extruded velocity by above-mentioned spinning solution, the spinning leaching after extrusion
Enter and be frozen into tow in 10~20 DEG C of deionized water, it is fine that load aFGF can be obtained in the tow freeze-drying after solidification
Dimension；
(5) pure cotton fiber and above-mentioned load aFGF fiber are carried out by 1:10 radical into stock, at blended at line after stock, and uses woven fabric
Machine is woven into gauze, and gauze is cut according to the size of 50mm × 50mm, 10~12h, freezing are freezed under the conditions of -10~-5 DEG C
Thaw 5~7h at room temperature afterwards, packs after defrosting, can be obtained and wound is promoted to repair bearing hydrocolloid dressing.
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| CN107281535B (en) * | 2017-08-10 | 2020-09-15 | 魏泓 | Giant salamander secretion viscous biomembrane and preparation method and application thereof |
| CN107519523B (en) * | 2017-10-18 | 2019-09-27 | 广州润虹医药科技股份有限公司 | A kind of alginates packing and its preparation method and application |
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