CN106265436A - There is formula and the preparation method of the disposable disinfectant solution of skin effect - Google Patents
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A—HUMAN NECESSITIES
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- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
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Abstract
There is formula and the preparation method of the disposable disinfectant solution of skin effect, being made up of thickening agent, disinfectant, cosolvent, inclusion agents, nertralizer, wetting agent, skin protectant, essence and deionized water, shared by the most each component, mass percent is: thickening agent 0.1% 1.0%；Disinfectant 0.1% 10.0%；Cosolvent 20.0% 40.0%；Inclusion agents 10.0% 20.0%；Nertralizer 0.2% 2.0%；Wetting agent 1.0% 10.0%；Skin protectant 1.0% 10.0%；Essence 0.2% 2.0%；Surplus is deionized water.The present invention solves the incompatible problem of zwitterion, enables anionic thickener carbomer and cationic disinfectant chlorhexidine gluconate to coexist in same system；Increase the preserving moisture and protecting skin effect of disinfectant solution, nourish hand skin, not only sterilize but also skin protection, on the basis of sterilization, protect skin；Strengthen sterilizing ability, sustained anti-microbial, prevent from infecting；Reduce the penetrating odor of disinfection composition so that it is smell more pure and fresh, it is easier to accepted by the public；It is convenient for carrying, uses more convenient, can sterilize whenever and wherever possible, be suitable for the disinfectant solution of public use.
Description
Technical field
The invention belongs to disinfectant solution preparing technical field, be specifically related to joining of a kind of disposable disinfectant solution with skin effect
Side and preparation method.
Background technology
The route of transmission infected is common with contact transmission, and wherein hands is most important propagation.On hand with substantial amounts of carefully
Bacterium, virus and cause a disease former, doing the disinfection of good hand is the important measures preventing from infecting.The use of hand disinfectant can remove or
Person kills hand tabernacle bacterium, and reduces hand and often occupy bacterium.Domestic and foreign hospitals hand hygiene product is mainly with soap lye and containing alcohol at present
Disinfectant is main, but soap lye needs to rinse with clear water, waste water resource and time；And containing alcohol disinfectant is due to ethanol addition
Height, alcohol smell is pungent, and damages hand skin, and moistening effect is bad.
Ethanol is the most frequently used disinfectant, the content of most hand disinfectant ethanol between 60%-80%, high concentration
Skin is easily caused damage by ethanol content.Ethanol has superpower penetration, can penetrate cell interior, makes protein coagulating
Degeneration.Ethanol volatilization can take away the large quantity of moisture on skin, causes skin hydropenia, causes skin to itch, Pi Gan, even can cause de-
Skin.But ethanol is as modal disinfectant, sterilizing ability is strong, if it is desired to life-time service, it is necessary to rationally add proportioning.
Popular hand hygiene consciousness is far away less than medical worker, and daily outdoor activity is certain to be stained with many thin on hand
Bacterium.When taking bus, when travelling, the time of going on business, when doing shopping, when going to hospital etc., all it is likely to the infected disease that causes
Produce.
Summary of the invention
The invention provides formula and the preparation method of a kind of disposable disinfectant solution with skin effect, to solve existing skill
The abnormal smells from the patient that art exists is pungent, damage hand skin, moistening effect are bad and the irrational problem of component proportion.
The technical solution adopted for the present invention to solve the technical problems is:
A kind of formula of the disposable disinfectant solution with skin effect, by thickening agent, disinfectant, cosolvent, inclusion agents, nertralizer,
Wetting agent, skin protectant, essence and deionized water form, and mass percent shared by the most each component is: thickening agent 0.1%-1.0%；
Disinfectant 0.1%-10.0%；Cosolvent 20.0%-40.0%；Inclusion agents 10.0%-20.0%；Nertralizer 0.2%-2.0%；Wetting agent
1.0%-10.0%；Skin protectant 1.0%-10.0%；Essence 0.2%-2.0%；Surplus is deionized water.
Above-mentioned thickening agent is carbomer.
Above-mentioned disinfectant is chlorhexidine gluconate or chlorhexidine acetate, first-selected chlorhexidine gluconate.
Above-mentioned cosolvent is ethanol.
Above-mentioned inclusion agents is at least one in alpha-cyclodextrin, beta-schardinger dextrin-and gamma-cyclodextrin.
Above-mentioned nertralizer is triethanolamine or sodium hydroxide, first-selected triethanolamine.
Above-mentioned wetting agent is in glycerol, butanediol, allantoin, ethoxy urea, propylene glycol, aminoacid and hyaluronic acid
Plant or several.
Above-mentioned skin protectant is in Aloe extract, vitamin E, snail extract, olive oil, Jojoba oil, marine polysaccharide
One or several.
The preparation method of the above-mentioned disposable disinfectant solution with skin effect, specifically comprises the following steps that
(1) deionized water being heated between 35 DEG C-45 DEG C, adds the carbomer of 0.1%-1.0%, stirring until being completely dissolved,
Temperature is down to room temperature, obtains solution A；
(2) deionized water is heated between 70 DEG C-80 DEG C, adds chlorhexidine gluconate and the 10.0%-of 0.2%-2.0%
20.0% inclusion agents, stirs 1h-2h, and temperature is down to room temperature, is obtained solution B；
(3) solution B is joined in solution A, stir 30min；
(4) add the triethanolamine mixing of the ethanol of 20.0%-40.0%, 0.2%-2.0%, stir 15min；
(5) add the wetting agent of 1.0%-10.0%, stir 15min；
(6) add the skin protectant of 1.0%-10.0%, stir 15min；
(7) add the pigment of 0.001%-0.01%, stir 15min；
(8) add the essence of 0.2%-2.0%, stir 15min；
(9) stand, fill.
The present invention solves the incompatible problem of zwitterion, makes anionic thickener carbomer and cationic disinfectant
Chlorhexidine gluconate can coexist in same system；Increase the preserving moisture and protecting skin effect of disinfectant solution, nourish hand skin, not only
Sterilize and skin protection, on the basis of sterilization, protect skin；Strengthen sterilizing ability, sustained anti-microbial, prevent from infecting；Reduce and sterilize into
The penetrating odor divided so that it is smell more pure and fresh, it is easier to accepted by the public；It is convenient for carrying, uses more convenient, whenever and wherever possible
Can sterilize, be suitable for the disinfectant solution of public use.
Detailed description of the invention
Example 1
The preparation method of a kind of disposable disinfectant solution with skin effect, comprises the steps:
1, deionized water being heated to 40 DEG C, add the carbomer of 0.1%, stirring is until being completely dissolved, and temperature is down to room temperature,
To solution A.
2, deionized water is heated to 70 DEG C, adds chlorhexidine gluconate and 10.0% inclusion agents of 1.0%, stir 2h,
Temperature is down to room temperature, obtains solution B.
3, solution B is joined in solution A, stir 30min.
4, add the ethanol of 20.0%, the triethanolamine of 0.2% mixes, stir 15min.
5, add 1.0% propylene glycol, 3.0% butanediol, 3.0% ethoxy urea, 2.0% hyaluronic acid, stir 15min.
6, add 3.0% snail extract, 3.0% Aloe extraction solution, 1.0% Jojoba oil, stir 15min.
7, add the pigment of 0.3%, stir 15min.
8, add the essence of 0.2%, stir 15min.
9, stand, fill.
Gained disinfectant solution is shallow white viscous liquid, flowable.
Example 2
The preparation method of a kind of disposable disinfectant solution with skin effect, comprises the steps:
1, deionized water being heated to 40 DEG C, add the carbomer of 0.3%, stirring is until being completely dissolved, and temperature is down to room temperature,
To solution A.
2, deionized water is heated to 75 DEG C, adds chlorhexidine gluconate and 20.0% inclusion agents of 1.5%, stir 2h,
Temperature is down to room temperature, obtains solution B.
3, solution B is joined in solution A, stir 30min.
4, add the ethanol of 30.0%, the triethanolamine of 0.5% mixes, stir 15min.
5, add 1.0% glycerol, 3.0% allantoin, 3.0% ethoxy urea, 2.0% hyaluronic acid, stir 15min.
6, add 2.0% snail extract, 2.0% Aloe extraction solution, 1.0% vitamin E, stir 15min.
7, add the pigment of 0.3%, stir 15min.
8, add the essence of 0.2%, stir 15min.
9, stand, fill.
Gained disinfectant solution is white viscous liquid, is difficult to flowing.
Example 3
The preparation method of a kind of disposable disinfectant solution with skin effect, comprises the steps:
1, deionized water being heated to 40 DEG C, add the carbomer of 0.3%, stirring is until being completely dissolved, and temperature is down to room temperature,
To solution A.
2, deionized water is heated to 75 DEG C, adds chlorhexidine gluconate and 15.0% inclusion agents of 1.5%, stir 2h,
Temperature is down to room temperature, obtains solution B.
3, solution B is joined in solution A, stir 30min.
4, add the ethanol of 40.0%, the triethanolamine of 0.5% mixes, stir 15min.
5, add 1.0% propylene glycol, 3.0% butanediol, 3.0% ethoxy urea, 2.0% hyaluronic acid, stir 15min.
6, add 3.0% snail extract, 3.0% Aloe extraction solution, 1.0% Jojoba oil, stir 15min.
7, add the pigment of 0.3%, stir 15min.
8, add the essence of 0.2%, stir 15min.
9, stand, fill.
Gained disinfectant solution is white viscous liquid, is difficult to flowing.
The present invention solves the incompatible problem of zwitterion, makes anionic thickener carbomer and cationic disinfectant
Chlorhexidine gluconate can coexist in same system；What the present invention was unique with the addition of wetting agent and skin protectant, enhances guarantor
Wet moisturizing effect, has maintenance effect to hand skin, and the generation of prevention hand wrinkle, life-time service effectively supplements water needed for skin
Point；Bactericidal effect of the present invention is good, is forming one layer of invisible protective film on hand, sustainable antibacterial；The present invention does not has traditional disinfection to become
The sharp aroma divided, smells more pure and fresh；The present invention is convenient for carrying, and uses more convenient, removes the fiber crops repasting hand cream after washing one's hands from
Tired, can sterilize whenever and wherever possible.
Claims (9)
1. there is a formula for the disposable disinfectant solution of skin effect, it is characterized in that by thickening agent, disinfectant, cosolvent, inclusion
Agent, nertralizer, wetting agent, skin protectant, essence and deionized water form, and mass percent shared by the most each component is: thickening agent
0.1%-1.0%；Disinfectant 0.1%-10.0%；Cosolvent 20.0%-40.0%；Inclusion agents 10.0%-20.0%；Nertralizer 0.2%-
2.0%；Wetting agent 1.0%-10.0%；Skin protectant 1.0%-10.0%；Essence 0.2%-2.0%；Surplus is deionized water.
The formula of the disposable disinfectant solution with skin effect the most according to claim 1, is characterized in that thickening agent is card ripple
Nurse.
The formula of the disposable disinfectant solution with skin effect the most according to claim 1, is characterized in that disinfectant is Fructus Vitis viniferae
Saccharic acid chlorhexidine or chlorhexidine acetate.
The formula of the disposable disinfectant solution with skin effect the most according to claim 1, is characterized in that cosolvent is ethanol.
The formula of the disposable disinfectant solution with skin effect the most according to claim 1, is characterized in that inclusion agents is α-ring
At least one in dextrin, beta-schardinger dextrin-and gamma-cyclodextrin.
The formula of the disposable disinfectant solution with skin effect the most according to claim 1, is characterized in that nertralizer is three second
Hydramine or sodium hydroxide.
The formula of the disposable disinfectant solution with skin effect the most according to claim 1, it is characterized in that wetting agent be glycerol,
One or several in butanediol, allantoin, ethoxy urea, propylene glycol, aminoacid and hyaluronic acid.
The formula of the disposable disinfectant solution with skin effect the most according to claim 3, is characterized in that skin protectant is Aloe
One or several in extract, vitamin E, snail extract, olive oil, Jojoba oil, marine polysaccharide.
9. the preparation method of the disposable disinfectant solution with skin effect described in claim 1, is characterized in that specifically comprising the following steps that
(1) deionized water being heated between 35 DEG C-45 DEG C, adds the carbomer of 0.1%-1.0%, stirring until being completely dissolved,
Temperature is down to room temperature, obtains solution A；
(2) deionized water is heated between 70 DEG C-80 DEG C, adds chlorhexidine gluconate and the 10.0%-of 0.2%-2.0%
20.0% inclusion agents, stirs 1h-2h, and temperature is down to room temperature, is obtained solution B；
(3) solution B is joined in solution A, stir 30min；
(4) add the triethanolamine mixing of the ethanol of 20.0%-40.0%, 0.2%-2.0%, stir 15min；
(5) add the wetting agent of 1.0%-10.0%, stir 15min；
(6) add the skin protectant of 1.0%-10.0%, stir 15min；
(7) add the pigment of 0.001%-0.01%, stir 15min；
(8) add the essence of 0.2%-2.0%, stir 15min；
(9) stand, fill.
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107929725A (en) * | 2017-12-28 | 2018-04-20 | 纽莱福泰姆网络服务（北京）有限公司 | A kind of environmentally friendly lysine polypeptide skin care thimerosal and its preparation process |
| CN110613620A (en) * | 2019-10-22 | 2019-12-27 | 佛山市时孖现代家居科技有限公司 | Washing-free alcohol disinfectant, using device and application thereof |
| CN111358714A (en) * | 2020-04-17 | 2020-07-03 | 广州荣创优品科技有限公司 | Silouch-containing skin-care type no-clean disinfectant and preparation method thereof |
| CN111544337A (en) * | 2020-06-17 | 2020-08-18 | 广东中科天元新能源科技有限公司 | Hyaluronic acid-containing moisturizing and skin-moistening no-wash gel disinfectant and preparation method thereof |
| CN112137913A (en) * | 2020-10-31 | 2020-12-29 | 佛山市特能宝化学原料有限公司 | Washing-free disinfection gel and preparation method thereof |
| CN112336671A (en) * | 2020-11-20 | 2021-02-09 | 山东消博士消毒科技股份有限公司 | Skin-care disinfectant and preparation method thereof |
| CN113384474A (en) * | 2021-06-04 | 2021-09-14 | 利康医药科技江苏有限公司 | Hand-washing-free disinfection gel and preparation method thereof |
| CN113398048A (en) * | 2021-07-01 | 2021-09-17 | 山东新华莎罗雅生物技术有限公司 | Skin-care repairing type quick-drying hand-washing-free disinfection emulsion and preparation method thereof |
| CN114432209A (en) * | 2020-10-30 | 2022-05-06 | 安徽德莱康生物医疗科技有限公司 | Hand-protecting type washing-free disinfection gel and preparation method thereof |
| CN114632017A (en) * | 2022-04-27 | 2022-06-17 | 山东利尔康医疗科技股份有限公司 | Hand disinfectant for inactivating coronavirus and preparation method thereof |
| CN114948774A (en) * | 2022-07-29 | 2022-08-30 | 山东新华莎罗雅生物技术有限公司 | Disinfecting hand sanitizer with coexistence of anions and cations and preparation method thereof |
| CN115531254A (en) * | 2022-09-20 | 2022-12-30 | 安徽达尔美生物科技有限公司 | Hand washing-free disinfectant |
| WO2023141689A1 (en) * | 2022-01-28 | 2023-08-03 | Universidade Federal De Minas Gerais - Ufmg | Long-lasting antimicrobial compositions containing cationic active agents and anionic excipients and uses |
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| CN101716186A (en) * | 2010-01-20 | 2010-06-02 | 华南理工大学 | Wound antibiotic flushing fluid and preparation method thereof |
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| CN110613620A (en) * | 2019-10-22 | 2019-12-27 | 佛山市时孖现代家居科技有限公司 | Washing-free alcohol disinfectant, using device and application thereof |
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| CN112137913A (en) * | 2020-10-31 | 2020-12-29 | 佛山市特能宝化学原料有限公司 | Washing-free disinfection gel and preparation method thereof |
| CN112336671A (en) * | 2020-11-20 | 2021-02-09 | 山东消博士消毒科技股份有限公司 | Skin-care disinfectant and preparation method thereof |
| CN113384474A (en) * | 2021-06-04 | 2021-09-14 | 利康医药科技江苏有限公司 | Hand-washing-free disinfection gel and preparation method thereof |
| CN113398048A (en) * | 2021-07-01 | 2021-09-17 | 山东新华莎罗雅生物技术有限公司 | Skin-care repairing type quick-drying hand-washing-free disinfection emulsion and preparation method thereof |
| WO2023141689A1 (en) * | 2022-01-28 | 2023-08-03 | Universidade Federal De Minas Gerais - Ufmg | Long-lasting antimicrobial compositions containing cationic active agents and anionic excipients and uses |
| CN114632017A (en) * | 2022-04-27 | 2022-06-17 | 山东利尔康医疗科技股份有限公司 | Hand disinfectant for inactivating coronavirus and preparation method thereof |
| CN114948774A (en) * | 2022-07-29 | 2022-08-30 | 山东新华莎罗雅生物技术有限公司 | Disinfecting hand sanitizer with coexistence of anions and cations and preparation method thereof |
| CN114948774B (en) * | 2022-07-29 | 2022-11-01 | 山东新华莎罗雅生物技术有限公司 | Disinfecting hand sanitizer with coexistence of anions and cations and preparation method thereof |
| CN115531254A (en) * | 2022-09-20 | 2022-12-30 | 安徽达尔美生物科技有限公司 | Hand washing-free disinfectant |
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