CN106236807B - Composition for preventing and treating influenza virus and traditional Chinese medicine compound oral instant membrane preparation - Google Patents
Composition for preventing and treating influenza virus and traditional Chinese medicine compound oral instant membrane preparation Download PDFInfo
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Abstract
The invention discloses a composition for preventing and treating influenza virus and a traditional Chinese medicine compound oral instant membrane preparation and a preparation method thereof. The composition for preventing and treating influenza virus comprises effective dose of (0.1-0.5) by weight: (1-10) the Dendranthema indicum extract and menthol. The traditional Chinese medicine compound oral instant membrane preparation comprises the following components in percentage by weight: 0.5 to 2.0 percent of glucomannan, 0.5 to 3.0 percent of softening agent, 0.1 to 0.5 percent of menthol, 1 to 10 percent of shennong chrysanthemum extract and 85 to 97.9 percent of water. The composition for preventing and treating influenza virus has an obvious anti-influenza virus effect. The traditional Chinese medicine compound oral instant membrane preparation has good tape casting film forming property, toughness and drug release property, and is safe and nontoxic.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a composition for preventing and treating influenza virus and a traditional Chinese medicine compound oral instant membrane preparation and a preparation method thereof.
Background
Influenza viruses spread as H1N1 type a: the transmission of influenza viruses is primarily airborne and secondarily contact transmission. Airborne transmission means that a person already infected with an influenza virus such as H1N1 releases a fine saliva (particle size less than 10 microns) with the influenza virus such as H1N1 into the air when coughing or sneezing, the slightly toxic aerosol-like particles float in the air and become infected if inhaled.
At present, most of the medicines for treating influenza virus are western medicines which have the characteristic of quick response but are easy to generate drug resistance. At present, traditional Chinese medicines are also adopted to treat influenza virus infection, but the traditional Chinese medicines have the problems of complex compatibility and high cost.
In addition, through the research on the invasion route and mode of influenza virus, the influenza virus such as H1N1 is divided and copied in the goblet cells of the epithelium of the mucous membrane of the soft palate in the upper part of the oral cavity after entering the nose or the pharynx, and then is released to the oral cavity or the nasopharynx along with the apical serous secretion form of the goblet cells and is discharged out of the body when coughing or sneezing, so the oral instant film agent can be used for accurately and directly killing the influenza virus such as H1N1 aiming at the condition of the influenza virus, and the oral instant film agent is more convenient, quicker and more compliant than oral solid medicine.
Oral Fast Dissolving Films (OFDF) are medicine carrying and releasing films which can be dissolved in Oral saliva, and are a novel administration form of a medicine delivery system. The OFDF is generally composed of a film forming agent (water-soluble polymer, the content of which is 40-50%), a softening agent (0-20%), a pigment perfume and a filling agent (0-40%), and is characterized in that: directly acts on pathogens or focus parts, and the medicine is directly absorbed through mucous membrane to avoid the first pass effect, and avoids the choking danger to children or old people lying in bed without water. The OFDF film-making technology is convenient to carry, does not need to be frozen in the production process, and is mature and reliable in the film-making technology since the 70-80 years of the last century. There are nearly 80 varieties in north america since 2003, mainly the number of common cold-treating OFDFs produced by nova pharmaceuticals and InnoZen corporation, costing 5 billion dollars in 2007, 20 billion dollars in 2012, and projected to reach 130 billion dollars in 2015.
Currently, OFDF is manufactured by a solvent casting method, a hot melt extrusion method, a semisolid casting method, a solid dispersion extrusion method, a rolling method, etc., but in any method, there are some problems such as: high energy consumption, difficult standardization of the physicochemical properties of the film, chemical substances of the film forming agent, and the addition of a softening agent, a filling agent and the like. The majority of drugs are chemically synthesized drugs. There are problems that the safety is not good and the film-forming weight is not good, resulting in the unsatisfactory drug effect.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide a composition for preventing and treating influenza virus, so as to solve the technical problems of drug resistance caused by overdue administration of western medicines for preventing and treating influenza virus, complex compatibility of Chinese medicinal formulas and high cost.
The invention also aims to provide a traditional Chinese medicine compound oral instant membrane preparation and a preparation method thereof, so as to solve the technical problems of unsafe oral instant membrane and poor drug effect caused by poor membrane forming weight.
In order to achieve the above object, according to one aspect of the present invention, there is provided a composition for controlling influenza virus. The composition for preventing and treating influenza virus comprises effective amounts of Dendranthema indicum extract and menthol; wherein the weight ratio of the Dendranthema indicum extract to the menthol is (0.1-0.5): (1-10).
In another aspect of the invention, a traditional Chinese medicine compound oral instant membrane preparation is provided. The traditional Chinese medicine compound oral instant membrane preparation contains the composition for preventing and treating influenza virus, and also contains glucomannan, a softening agent and water, and the total weight of the traditional Chinese medicine compound oral instant membrane preparation is 100 percent, and the content of the components of the Dendranthema indicum extract, the menthol glucomannan, the softening agent and the water is as follows:
in another aspect of the invention, a preparation method of the traditional Chinese medicine compound oral instant membrane preparation. The preparation method comprises the following steps:
weighing raw materials of the components according to the components contained in the traditional Chinese medicine compound oral instant membrane preparation;
adding the weighed shennong chrysanthemum extract, menthol glucomannan and softening agent into the water component for mixing treatment.
Compared with the prior art, the composition for preventing and treating influenza virus takes the effective amount of the extract of the Dendranthema indicum as the functional component, and after the extract is compatible with the menthol, the extract and the menthol can play a role in synergism of administration, so that the composition for preventing and treating influenza virus in the embodiment of the invention has an obvious anti-influenza virus effect, such as an obvious antiviral effect on H1N 1A.
The traditional Chinese medicine compound oral instant membrane preparation adopts the composition for preventing and treating influenza virus as an effective functional component, so that the traditional Chinese medicine compound oral instant membrane preparation has an obvious effect of resisting influenza virus. The glucomannan is used as a film forming agent, and under the synergistic effect of a softening agent, the traditional Chinese medicine compound oral instant film preparation has good tape casting film forming performance, is flat and smooth in film forming, soft, tough, safe and nontoxic, and can enable the composition for preventing and treating influenza virus to be compatible with the film forming agent, and the composition for preventing and treating influenza virus has good release degree.
The preparation method of the traditional Chinese medicine compound oral instant membrane preparation dissolves all functional components in water components, thereby ensuring the stability and the drug effect stability of the traditional Chinese medicine compound oral instant membrane preparation system, and having the advantages of safety, no toxicity, controllable weight, low cost and good industrial feasibility.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The weight of each component mentioned in the description of the embodiment of the invention can not only indicate the proportional relation of each component, but also indicate the specific content of each group, therefore, the content of each component of the composition according to the description of the embodiment of the invention is enlarged or reduced in proportion to be within the scope disclosed in the description of the embodiment of the invention. Specifically, the weight described in the description of the embodiments of the present invention may be a unit of weight known in the medical field, such as μ g, mg, g, kg.
In one aspect, the embodiments of the present invention provide a composition for preventing and treating influenza virus. In one embodiment, the influenza control composition comprises an effective amount of a. shennong chamomilla extract and menthol.
The Dendranthema indicum was discovered in 1982 and was identified as a new variety of Compositae plants, and the chrysanthemum is derived from a wild chrysanthemum variety, and not only has the pharmacological action of the wild chrysanthemum, but also has unique characteristics, such as full-bodied fragrance of flowers, leaves, stems and roots. Researches show that effective amount of the Dendranthema indicum extract has antiviral effect, and after the Dendranthema indicum extract is compatible with menthol, the Dendranthema indicum extract and the menthol can play a role in synergism of administration, so that the embodiment of the inventionThe composition has significant antiviral effect on influenza virus, such as type A H1N1Has obvious antiviral effect.
In one embodiment, the extract of Dendranthema indicum is obtained by extracting under the following extraction conditions:
adopting dry stems and/or leaves of Dendranthema indicum as a raw material, and performing reflux extraction treatment on the raw material; the temperature of the reflux extraction treatment is 60-80 ℃, the pressure is 0.6-0.8 atmospheric pressure, the reflux extraction is carried out for 1-2 hours, and the solvent of the reflux extraction treatment is water. In a specific embodiment, the temperature of the reflux extraction treatment is 80 ℃, the pressure is 0.8 atm, the reflux extraction is performed for 1 hour, and the solvent of the reflux extraction treatment is water.
In a specific embodiment, the method of the reflux extraction process is as follows:
firstly, cleaning dried stems and leaves of Dendranthema indicum and then drying (if the water content is controlled to be less than or equal to 12%);
crushing the dried stems and leaves and sieving the crushed stems and leaves with a 30-mesh sieve;
thirdly, reflux extraction (the reflux extraction temperature is 60-80 ℃, the pressure is 0.6-0.8 atmospheric pressure, the reflux extraction is 1-2 hours, the preferred reflux extraction treatment temperature is 80 ℃, the pressure is 0.8 atmospheric pressure, the soaking is 30 minutes, and the reflux extraction is 1 hour, wherein, the reflux extraction solvent is water, and the material-liquid ratio is that the volume ratio of the raw material to the water is 1 (10-30), specifically 1: 20);
fourthly, filtering and collecting filtrate (if three layers of gauze are adopted for filtering treatment);
fifthly, drying the recovered solution in vacuum (for example, drying until the crude drug ratio is 1:1 or 1: 1.2).
The control of the effective components and content of the Dendranthema indicum extract is realized by controlling the extraction process conditions of the Dendranthema indicum raw material, so that the composition for preventing and treating influenza virus provided by the embodiment of the invention has good clinical effects on influenza virus resistance such as H1N 1A resistance.
In order to effectively extract the anti-influenza virus component contained in the Dendranthema indicum, in a further embodiment, the ratio of the raw material to water is controlled to be 1: 20.
in addition, on the basis of the above-described embodiments, the effective amount of the Dendranthema indicum extract means an amount sufficient to show a benefit or clinical significance to an individual for the influenza virus-controlling composition of the present invention. One skilled in the art will appreciate that the actual amount or dose administered and the time course of administration will depend on the nature and severity of the disease being treated, the age and general condition of the subject being treated, and the mode of administration, among other factors.
The menthol has the effects of refreshing, diminishing inflammation and relieving pain of penetrant, can play a synergistic effect on the functional component of the Dendranthema indicum extract, and improves the clinical effect of the Dendranthema indicum extract on resisting influenza viruses. At the same time, it also acts as a flavouring agent due to the specific taste of menthol.
In one embodiment, the weight ratio of the Dendranthema indicum extract to menthol is controlled to be (0.1-0.5): (1-10). The weight ratio of the two is controlled within the range, so that the two play a synergistic effect, and the clinical effect of the Dendranthema indicum extract on resisting influenza viruses is improved.
Therefore, the influenza virus prevention and treatment composition provided by the embodiment of the invention takes an effective amount of the dendranthema indicum extract as a functional component, and the effective amount of the dendranthema indicum extract and the menthol are compatible, so that the dendranthema indicum extract and the menthol can play a synergistic effect of administration, and therefore, the influenza virus prevention and treatment composition provided by the embodiment of the invention has an obvious anti-influenza virus effect, is safe to use, and does not generate drug resistance.
On the basis of the above embodiments, the influenza virus prevention and treatment composition according to the embodiments of the present invention may further include a pharmaceutically acceptable adjuvant, which refers to any adjuvant known to those skilled in the art to be suitable for a specific administration mode. As in particular embodiments, the pharmaceutically acceptable excipients may include one or more pharmaceutically acceptable carriers, solvents, excipients, buffers, stabilizers, adjuvants, prodrugs and other therapeutic agents whose treatment benefits from or enhances the above-described influenza virus control compositions that are compatible with the functional components shennong chrysanthemum extract and menthol. It is to be understood that each of the adjuvants described above should be non-toxic, not interfere with or impair the function and action of the influenza virus control compositions of the embodiments of the present invention. In addition, the auxiliary materials can be selected flexibly according to the existing preparation formulation of the influenza virus prevention and treatment composition in the embodiment. In one embodiment, the excipient is a film-forming agent.
Therefore, on the other hand, the embodiment of the invention also provides a traditional Chinese medicine compound oral instant membrane preparation. In one embodiment, the traditional Chinese medicine compound oral instant membrane preparation contains the composition for preventing and treating influenza virus, and also contains components such as glucomannan, a softening agent, water and the like. The traditional Chinese medicine compound oral instant membrane preparation comprises the following components in percentage by weight, based on 100% of the total weight of the traditional Chinese medicine compound oral instant membrane preparation:
the glucomannan contained in the traditional Chinese medicine compound oral instant membrane preparation has the characteristics of water solubility, gel solubility, membrane forming property, rheological property and the like, so that the glucomannan is used as a membrane forming agent in the embodiment of the invention. According to research, in the embodiment of the invention, when the weight fraction of the sol is 0.5-2.0%, the sol can be in a sol state, and the sol can form a film within 30 minutes after casting. The preferred glucan is required to have a purity of more than 90% to ensure the film-forming quality. In addition, the glucan is a dietary fiber, and can be decomposed into short-chain fatty acids in the intestinal tract after being absorbed by a human body, so that the short-chain fatty acids are beneficial to probiotics and promote intestinal peristalsis, and therefore, the glucan is a good film forming agent, and is safe to use.
The softening agent can assist glucomannan to form a film, improve the film forming quality of the traditional Chinese medicine compound oral instant film preparation, endow the traditional Chinese medicine compound oral instant film preparation with good tape casting film forming performance, ensure that the formed film is flat, smooth, soft and tough, safe and nontoxic, and ensure that the composition for preventing and treating influenza virus is compatible with the film forming agent, so that the composition for preventing and treating influenza virus such as the Dendranthema indicum extract and menthol has good release degree.
In one embodiment, the softening agent is at least one of lecithin, glycerin and sorbitol. By selecting the softening agent, the synergistic effect of film forming can be exerted between the softening agent and glucomannan, the film forming quality is improved, the compatibility of the composition for preventing and treating influenza virus, such as the Dendranthema indicum extract and the menthol, with the film forming agent is improved, and the release degree of the composition for preventing and treating influenza virus is improved.
The water component contained in the Chinese medicinal compound oral instant membrane preparation should be water meeting the medical field standard, such as purified water, distilled water, etc.
Therefore, the compound oral instant membrane preparation of the embodiment of the invention adopts the composition for preventing and treating influenza virus as an effective functional component, and has an obvious anti-influenza virus effect. The composition has good casting film forming property, is soft and tough, is safe and nontoxic, and can ensure that the composition for preventing and treating influenza virus has good release degree and high compatibility with a film forming agent.
In another aspect, on the basis of the compound oral instant membrane preparation in the embodiments of the present invention, the embodiments of the present invention provide a preparation method of the compound oral instant membrane preparation. In one embodiment, the preparation method of the compound oral instant membrane preparation comprises the following steps:
step S01: weighing raw materials of the components according to the components contained in the traditional Chinese medicine compound oral instant membrane preparation;
step S02: adding the Dendranthema indicum extract, the menthol glucomannan and the softening agent which are weighed in the step S01 into the water component for mixing treatment.
The components and the contents of the components of the compound oral instant film preparation of traditional Chinese medicine described in the above step S01 are as described in the above compound oral instant film preparation of traditional Chinese medicine, and are not described herein again for the sake of brevity.
The mixing treatment in step S02 may be a conventional mixing method of medicinal materials, or may be a stirring and mixing method directly, or may be an ultrasonic treatment method, and any method may be used as long as it is a sol that can achieve uniform dissolution or dispersion of each component in water to form a stable dispersion system.
In a preferred embodiment, the method for mixing the weighed shennong chrysanthemum extract, menthol glucomannan and softening agent into the water component in the step S02 is as follows:
dissolving the glucomannan in water, adding water while stirring until the glucomannan is completely dissolved into a sol state, and obtaining glucomannan sol;
dissolving the menthol in water to prepare menthol aqueous solution;
heating 1% -2% sodium hydroxide solution to 85-100 deg.C, adding softener under stirring, cooling to 30-40 deg.C, filtering, and controlling pH of filtrate to 8-9 to obtain softener emulsion; in one embodiment, the softening agent is at least one of lecithin, glycerin and sorbitol.
Dissolving the Dendranthema indicum extract with water to prepare an aqueous solution of the Dendranthema indicum extract;
adding the menthol aqueous solution into glucomannan sol for mixing treatment, and then adding the lecithin emulsion for continuously mixing treatment.
Wherein, the steps of obtaining glucomannan sol, preparing menthol aqueous solution, obtaining lecithin emulsion and preparing shennong chrysanthemum extract aqueous solution have no requirement of sequence. Through the mixing treatment mode, the components can be uniformly dispersed to form stable sol, so that the film forming quality of the traditional Chinese medicine compound oral instant film is improved, the stable release of the anti-influenza virus and influenza virus prevention and control composition is improved, and the drug effect stability of the traditional Chinese medicine compound oral instant film preparation is improved.
Therefore, the preparation method of the traditional Chinese medicine compound oral instant membrane in the embodiment of the invention ensures that the traditional Chinese medicine compound oral instant membrane preparation has stable efficacy, safety, no toxicity, low cost and good industrial feasibility.
The invention is further explained by specific embodiments of the composition for preventing and treating influenza virus, the traditional Chinese medicine compound oral instant membrane and the preparation method thereof.
Example of composition for controlling influenza virus
Example 11
The present example provides a composition for controlling influenza virus. The composition for preventing and treating influenza virus comprises effective amounts of Dendranthema indicum extract and menthol; wherein the weight ratio of the Dendranthema indicum extract to the menthol is 10: 0.5.
wherein, the Dendranthema indicum extract is extracted according to the following method:
extracting dry flowers of Dendranthema indicum by a water extraction method: pulverizing dried flower, sieving with 30 mesh sieve at material-to-liquid ratio of 1:10, soaking for 30 min, extracting for 1 hr (at 95 deg.C), and filtering the extractive solution. Extracting with 10 times of water for the second time (the conditions are the same as those of the first time), mixing the filtrates, and concentrating to 1:1 or 1:1.2.
Example 12
The present example provides a composition for controlling influenza virus. The composition for preventing and treating influenza virus comprises effective amounts of Dendranthema indicum extract and menthol; wherein the weight ratio of the Dendranthema indicum extract to the menthol is (0.1-0.5): (1-10).
Wherein, the Dendranthema indicum extract is extracted according to the following method:
dry stems and leaves of Dendranthema indicum are used as raw materials, and a dynamic reflux method is adopted for extraction.
Example 13
Dissolving menthol: because menthol is slightly soluble in water, the menthol should be dissolved by accurately releasing the used amount and then placing the menthol in a beaker, adding 100ml of water, heating and stirring until the menthol is completely dissolved.
Example 14
The quality standard of glucomannan is as follows: the purity of glucomannan is more than or equal to 90 percent, and the grain diameter of powder is less than or equal to 0.125mm and is more than or equal to 90 percent. The glucomannan which reaches the standard has strong bacteriostatic ability, so the compound film forming agent also has functions and effects.
Embodiment of a compound oral instant membrane preparation of traditional Chinese medicine
Example 21
The embodiment provides a traditional Chinese medicine compound oral instant membrane preparation. The traditional Chinese medicine compound oral instant membrane preparation contains the composition for preventing and treating influenza virus in the embodiment 11, and also contains glucomannan, a softening agent and water, wherein the total weight of the traditional Chinese medicine compound oral instant membrane preparation is 100%, and the shennong chrysanthemum extract, the menthol glucomannan, the softening agent and the water comprise the following components in percentage by weight:
the preparation method of the traditional Chinese medicine compound oral instant membrane preparation comprises the following steps:
s11: according to the compatibility content of the components of the compound traditional Chinese medicine oral instant membrane preparation of the embodiment 21, the glucomannan is dissolved by purified water, and water is added while stirring until the glucomannan is completely dissolved into a sol state;
s12: dissolving menthol with purified water;
s13: lecithin was dissolved in 1% -2% sodium hydroxide solution. Heating sodium hydroxide solution to 85-100 deg.C, adding lecithin under stirring, cooling to 30-40 deg.C, sieving with 100 mesh sieve to obtain emulsion with pH of 8-9 and weak alkalinity;
s14: dissolving the Dendranthema indicum extract with purified water;
s15: adding menthol solution into glucomannan sol, stirring, adding lecithin emulsion, and stirring.
Example 22
The embodiment provides a traditional Chinese medicine compound oral instant membrane preparation. The traditional Chinese medicine compound oral instant membrane preparation contains the composition for preventing and treating influenza virus in the embodiment 12, and also contains glucomannan, a softening agent and water, wherein the total weight of the traditional Chinese medicine compound oral instant membrane preparation is 100%, and the shennong chrysanthemum extract, the menthol glucomannan, the softening agent and the water comprise the following components in percentage by weight:
the preparation method of the traditional Chinese medicine compound oral instant membrane preparation refers to the preparation method in example 21.
Correlation test
The clinical experiment of the traditional Chinese medicine compound oral instant membrane preparation provided in the embodiment 21 is as follows:
1. film formation test:
the compound oral instant membrane preparation of the traditional Chinese medicine provided in example 21 was directly placed on a glass plate, after one minute, the film was lightly coated on the glass plate with a flat scraper, and then placed in a greenhouse to be dried until the film can be removed. Therefore, the traditional Chinese medicine compound oral instant membrane preparation provided by the embodiment of the invention has good film forming property and better toughness.
2. Examples of in vitro antiviral experiments:
the compound oral instant membrane preparation of the traditional Chinese medicine provided in the above examples 21 to 22 was subjected to in vitro antiviral experiments by the MTT method. Dog kidney cells (MDCK) were used for cytotoxicity experiments, which were performed by conventional plate method to determine half the effective dose (IC50), Therapeutic Index (TI) and virus inhibition rate, respectively, and the results are shown in Table 1.
TABLE 1 antiviral effect of compound oral instant membrane preparation for influenza A virus H1N1
TABLE 1 Compound oral instant membrane preparation for treating A type H1N1Antiviral effect of influenza Virus
The test results in the table 1 show that the traditional Chinese medicine compound oral instant membrane preparation prepared from the Dendranthema indicum extract has better antiviral effect in vitro, wherein the stem and leaf extract is better than the flower extract.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (6)
1. A composition for controlling influenza virus, comprising: the composition for preventing and treating influenza virus consists of effective dose of Dendranthema indicum extract and menthol; wherein the weight ratio of the Dendranthema indicum extract to the menthol is (0.1-0.5): (1-10); the influenza virus is H1N 1A;
wherein, the Dendranthema indicum extract is obtained by extracting according to the following extraction conditions:
adopting dry stems and/or leaves of Dendranthema indicum as a raw material, and performing reflux extraction treatment on the raw material; the temperature of the reflux extraction treatment is 60-80 ℃, the pressure is 0.6-0.8 atmospheric pressure, the reflux extraction is carried out for 1-2 hours, and the solvent of the reflux extraction treatment is water.
2. The composition for controlling influenza virus according to claim 1, wherein: the volume ratio of the raw materials to the water is 1 (10-30).
3. A traditional Chinese medicine compound oral instant membrane preparation is characterized in that: the composition for preventing and treating influenza virus, which contains the composition for preventing and treating influenza virus as claimed in claim 1 or 2, and also contains glucomannan, a softening agent and water, wherein the total weight of the traditional Chinese medicine compound oral instant membrane preparation is 100%, and the content percentages of the components of the Dendranthema indicum extract, the menthol, the glucomannan, the softening agent and the water are as follows:
4. the traditional Chinese medicine compound oral instant membrane preparation according to claim 3, which is characterized in that: the softening agent is at least one of lecithin, glycerin and sorbitol.
5. A preparation method of a traditional Chinese medicine compound oral instant membrane preparation is characterized by comprising the following steps: the method comprises the following steps:
weighing raw materials of the traditional Chinese medicine compound oral instant membrane preparation according to the components in the traditional Chinese medicine compound oral instant membrane preparation of claim 3 or 4;
adding the weighed shennong chrysanthemum extract, menthol, glucomannan and softening agent into the water component for mixing treatment.
6. The method of claim 5, wherein: the method for mixing and processing the weighed shennong chrysanthemum extract, menthol, glucomannan and softening agent by adding the water components comprises the following steps:
dissolving the glucomannan in water, adding water while stirring until the glucomannan is completely dissolved into a sol state, and obtaining glucomannan sol;
dissolving the menthol in water to prepare menthol aqueous solution;
heating 1% -2% sodium hydroxide solution to 85-100 deg.C, adding lecithin under stirring, cooling to 30-40 deg.C, filtering, and controlling pH of filtrate to 8-9 to obtain lecithin emulsion;
dissolving the Dendranthema indicum extract with water to prepare an aqueous solution of the Dendranthema indicum extract;
adding the menthol aqueous solution into glucomannan sol for mixing treatment, and then adding the lecithin emulsion for continuously mixing treatment.
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| JP6893650B2 (en) * | 2017-02-24 | 2021-06-23 | 学校法人福岡大学 | Release-controlled film containing water-soluble polysaccharides as the main component |
| KR102524075B1 (en) * | 2022-06-22 | 2023-04-21 | 한국 한의학 연구원 | Composition for preventing, ameliorating or treating coronavirus infectious disease comprising herbal medicine extract as effective component |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101991694A (en) * | 2009-08-25 | 2011-03-30 | 北京以岭药业有限公司 | Application of traditional Chinese medical composition in preparation of medicament for resisting influenza A H1N1 influenza viruses |
| CN102085311A (en) * | 2009-12-02 | 2011-06-08 | 广州青蒿医药科技有限公司 | Traditional Chinese medicinal composition for preventing or treating common cold and/or flu, method for preparing same and application thereof |
| WO2011143844A1 (en) * | 2010-05-21 | 2011-11-24 | 深圳市齐旺投资有限公司 | Traditional chinese medicine composition for treating infection of influenza a virus subtype and preparation method thereof |
| WO2014190555A1 (en) * | 2013-05-31 | 2014-12-04 | Qu Jinglai | Traditional chinese medicine composition for resisting influenza a virus infection and relieving cough, and preparation method therefor |
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| KR20030019097A (en) * | 2001-08-27 | 2003-03-06 | 주식회사 바이오메딕스 | Compositions for treatment and prevention of cold having antiviral activity |
| US20120328675A1 (en) * | 2010-03-03 | 2012-12-27 | Kowa Co., Ltd. | Film preparation containing medicament with unpleasant taste |
| CN102824333B (en) * | 2012-09-26 | 2014-05-14 | 苏州大学 | Oral quick-dissolving film preparation and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991694A (en) * | 2009-08-25 | 2011-03-30 | 北京以岭药业有限公司 | Application of traditional Chinese medical composition in preparation of medicament for resisting influenza A H1N1 influenza viruses |
| CN102085311A (en) * | 2009-12-02 | 2011-06-08 | 广州青蒿医药科技有限公司 | Traditional Chinese medicinal composition for preventing or treating common cold and/or flu, method for preparing same and application thereof |
| WO2011143844A1 (en) * | 2010-05-21 | 2011-11-24 | 深圳市齐旺投资有限公司 | Traditional chinese medicine composition for treating infection of influenza a virus subtype and preparation method thereof |
| WO2014190555A1 (en) * | 2013-05-31 | 2014-12-04 | Qu Jinglai | Traditional chinese medicine composition for resisting influenza a virus infection and relieving cough, and preparation method therefor |
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Address after: 518000 room 702, Pioneer Park, University Town, Taoyuan street, Nanshan District, Shenzhen, Guangdong Applicant after: Shenzhen Shennong special medicine food Development Co Ltd Address before: 518000 room 702, Pioneer Park, University Town, Taoyuan street, Nanshan District, Shenzhen, Guangdong Applicant before: SHENZHEN SHENNONG SPRING PLANT SUBSTANCES DEVELOPMENT CO., LTD. |
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Address after: 518000 Shenzhen District, Longhua, Guangdong province Longhua Street Qinglong Road 6, Hong Kong Science and Technology Park incubator 3 floor E area Applicant after: Shenzhen Shennong Special Medical Food Co., Ltd. Address before: 518000 Guangdong Shenzhen Nanshan District Taoyuan Street Li Shan Road University Town Pioneer Park 702 room Applicant before: Shenzhen Shennong special medicine food Development Co Ltd |
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