CN106093445A - There is automatic clinical chemistry analyzer and the analysis method of noncontact air pressure agitating device - Google Patents
There is automatic clinical chemistry analyzer and the analysis method of noncontact air pressure agitating device Download PDFInfo
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- CN106093445A CN106093445A CN201610688975.7A CN201610688975A CN106093445A CN 106093445 A CN106093445 A CN 106093445A CN 201610688975 A CN201610688975 A CN 201610688975A CN 106093445 A CN106093445 A CN 106093445A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00534—Mixing by a special element, e.g. stirrer
- G01N2035/00544—Mixing by a special element, e.g. stirrer using fluid flow
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a kind of automatic clinical chemistry analyzer with noncontact air pressure agitating device and analysis method, this analyser includes that reagent disc, specimen disc, reaction tray, detection device, detection cup clean device and noncontact air pressure agitating device, described noncontact air pressure agitating device is made up of air pump, pressure-regulating device, connecting tube and barostat, noncontact air pressure agitating device is by barostat liquid surface local surge spray air-flow in detection cup, in ordering about cup, liquid forms flowing due to pressure inequality, reaches the effect of liquid in mixing detection cup.The present invention makes micro liquid stirring in automatic clinical chemistry analyzer detection cup is realized cordless by application noncontact air pressure agitating device, can be prevented effectively from, reduce difference reagent and the cross-contamination of sample room when automatic clinical chemistry analyzer detects, thus improve detection accuracy, and substantially reduce cleaning institute water consumption.
Description
Technical field
The invention belongs to medical test detection technique field, a kind of have noncontact air pressure agitating device complete from
Automatic Biochemical Analyzer and the method for analysis.
Background technology
Medical test automatic clinical chemistry analyzer usually needs to be stirred the reactant liquor of trace making it abundant at present
Mix and react, it is ensured that the accuracy of testing result.
The agitating device that existing automatic clinical chemistry analyzer is used has magnetic agitation, deep layer air agitation and ultrasound wave to stir
The mode such as mix.First two is contact stirring, owing to the sample of each reactant liquor is different with the reagent used, therefore stirs
After agitator have to be carried out.And the types of agents difference contacted due to agitator, simple water cleans often difficult
To reach good result, the most usually due to the reactant liquor of residual on stirring-head, during to next reactant liquor stirring, make this reaction
Liquid composition, or pH value changes the accuracy of detection of the next sample of impact.Ultrasound wave is contactless stirring, but with directly
Contact alr mode compares, and ultrasound wave is relatively big at stirring of identical time equal amount liquid power demand, and to detection cup
Certain damage can be caused Deng instrument component.
Summary of the invention
It is an object of the invention to provide a kind of automatic clinical chemistry analyzer with noncontact air pressure agitating device and divide
Analysis method.
The technical scheme realizing the object of the invention is: a kind of full-automatic biochemical analysis with noncontact air pressure agitating device
Instrument, this analyser includes that reagent disc, specimen disc, reaction tray, detection device, detection cup clean device and noncontact air pressure stirring dress
Put;
Described reagent disc is used for placing reagent bottle;Described specimen disc is used for placing sample cell or specimen cup;Described reaction tray
For placing detection cup;Described detection device is for carrying out optical signal detecting to liquid in detection cup;Described detection cup cleans dress
Put for cleaning detection cup;
Described noncontact air pressure agitating device is made up of air pump, pressure-regulating device, connecting tube and barostat;
Described air pump is used for blasting air and being sprayed by barostat;
Described barostat is arranged on above detection cup, for non-contacting liquid surface applying impact gas in detection cup
Pressure;
Described pressure-regulating device is for regulating air-flow size, speed and the time of barostat ejection;
Described connecting tube is for air pump, barostat and the connection of pressure-regulating device.
A kind of analysis method of automatic clinical chemistry analyzer with noncontact air pressure agitating device, comprises the following steps:
Step 1, analyser need according to detection, progressively reagent, sample are added in the detection cup in reaction tray;
Below step 2, mobile detection cup to barostat, barostat sprays impact air-flow in detection cup, and passes through pressure
Air-flow size, speed and time in adjusting means regulation barostat;Impact air-flow position one or more to liquid level forms impact
Air pressure, makes detection cup liquid level form draught head, drives liquid flowing, completes to detect liquid agitation in cup;
Step 3, by detection device to detection cup in liquid carry out optical signal detecting;
Step 4, complete detection after, by detection cup clean device to detection cup be carried out, under proceeding after cleaning
The detection of one circulation.
Compared with prior art, the remarkable result of the present invention is:
(1) automatic clinical chemistry analyzer with noncontact air pressure agitating device and the analysis method of the present invention is connect by non-
Touch air-flow quickly, directly stir to micro liquid in detection cup, both can consume excessive power and time, avoid again
Agitating device directly contacts the cross-contamination issue caused with reactant liquor;(2) present invention be applicable to micro liquid stirring mix
Even, and need not agitator is carried out.
Accompanying drawing explanation
Fig. 1 (a) is barostat liquid flow schematic diagram in detection cup when producing impact air pressure on the left of liquid level, and Fig. 1 (b) is
Barostat stops liquid backflow schematic diagram after pressure, and Fig. 1 (c) is for detecting liquid level schematic diagram in cup after stirring.
Fig. 2 (a) and Fig. 2 (b) is respectively positioned at ullage when opening alternately relative to two barostats of position, sample cell
Middle liquid flow schematic diagram, Fig. 2 (c) is for detecting liquid level schematic diagram in cup after stirring.
Fig. 3 (a) is to detect liquid flow schematic diagram in cup after barostat produces impact air pressure in the middle part of liquid level, and Fig. 3 (b) is
Barostat stops liquid backflow schematic diagram after pressure, and Fig. 3 (c) is for detecting liquid level schematic diagram in cup after stirring.
Fig. 4 (a) is that elbow barostat is at an angle to detecting liquid flowing in cup after producing impact air pressure in the middle part of liquid level
Schematic diagram, Fig. 4 (b) is that barostat stops liquid backflow schematic diagram after pressure, and Fig. 4 (c) is for detecting liquid level signal in cup after stirring
Figure, Fig. 4 (d) is the top view of Fig. 4 (a).
Fig. 5 is analyser structural representation in the embodiment of the present invention 5.
Fig. 6 is analyser structural representation in the embodiment of the present invention 7.
Detailed description of the invention
A kind of automatic clinical chemistry analyzer with noncontact air pressure agitating device of the present invention, this analyser includes reagent
Dish, specimen disc, reaction tray, detection device, detection cup clean device and noncontact air pressure agitating device;
Described reagent disc is used for placing reagent bottle;Described specimen disc is used for placing sample cell or specimen cup;Described reaction tray
For placing detection cup;Described detection device is for carrying out optical signal detecting to liquid in detection cup;Described detection cup cleans dress
Put for cleaning detection cup;
Described noncontact air pressure agitating device is made up of air pump, pressure-regulating device, connecting tube and barostat;
Described air pump is used for blasting air and being sprayed by barostat, produces impact air pressure at the liquid surface being stirred
Form uneven pressure;
Described barostat is arranged on above detection cup, for non-contacting liquid surface applying impact gas in detection cup
Pressure;
Described pressure-regulating device is for regulating air-flow size, speed and the time of barostat ejection;
Described connecting tube is for air pump, barostat and the connection of pressure-regulating device.
Further, described barostat is for the non-contacting liquid surface local applying punching less than 50% in detection cup
Hitting air pressure, in ordering about cup, liquid forms flowing due to pressure inequality, liquid in mixing detection cup.
Further, described barostat is more than 1, and is arranged at above same detection cup;Stop when reaction tray rotates
Time only, each barostat is in turn to liquid in a detection cup liquid level difference localized ejection air pressure realization detection cup due to difference locally
The air pressure that surface is born is different, and forms liquid flowing in detection cup, and when pressure point changes and stops, liquid occurs separately again
The flowing of one state, therefore reaches the effect of mixing to the liquid in detection cup.
Further, described barostat is more than 1, and each barostat is separately positioned on instrument reaction tray difference detection cup position
Top.When reaction tray rotates stopping, each barostat is the most respectively to liquid level localized ejection air pressure in multiple detection cups, simultaneously
Stir liquid in multiple detection cup.
Further, this automatic clinical chemistry analyzer also includes cleaning device, for purgative gas pressing surfaces externally and internally.
Further, described barostat Way out and the angle in liquid level face are more than 30 degree.
Further, pressure-regulating device is adjustable valve or adjustable pressure tank, is used for controlling barostat continuously or discontinuously
Apply air pressure.
Further, described noncontact air pressure agitating device also includes heating and attemperating unit, described heating and temperature control dress
Put and include that heater and radiator valve, heater and radiator valve are encircled and be arranged on barostat periphery, be respectively used to gas
In pressing, gas carries out heating and keeping constant temperature.The gas temperature that described barostat is sprayed is 20-50 DEG C.
Further, this automatic clinical chemistry analyzer also includes barostat mobile device, and described barostat mobile device is used
In driving barostat operationally carry out angle adjustment or move horizontally, by liquid level difference local pressure is sufficiently stirred for liquid
Body.
The present invention also provides for a kind of analysis method of automatic clinical chemistry analyzer with noncontact air pressure agitating device, bag
Include following steps:
Step 1, instrument need according to detection automatically, progressively reagent, sample are added in each detection cup in reaction tray;
Below step 2, mobile detection cup to barostat, barostat sprays impact air-flow in detection cup, and passes through pressure
Air-flow size, speed and time in adjusting means regulation barostat;Impact air-flow position one or more to liquid level forms impact
Air pressure, makes detection cup liquid level form draught head, drives liquid flowing, completes to detect liquid agitation in cup;
Step 3, by detection device to detection cup in liquid carry out optical signal detecting;
Step 4, complete detection after, by detection cup clean device to detection cup be carried out, under proceeding after cleaning
The detection of one circulation.
Further, in step 2, the different loci of barostat to be two one group be arranged at same detection cup position, is performing
Two pinwheel stream jet bodies during stirring, i.e. during one of them pin jet, another pin stops, and the air pressure sprayed the most in turn intersects to be made
With liquid different surfaces in detection cup so that in detection cup, liquid difference local occurs that high pressure-low pressure is changed in turn, drives detection
In cup, liquid is more rapid, flow thoroughly.
Further, barostat carries out angle adjustment in jet whipping process or moves horizontally so that produce in detection cup
The hyperbar of raw different localized site, forms the flowing of multi-mode liquid during a detection.
The invention will be further described with embodiment below in conjunction with the accompanying drawings.
Embodiment 1
A kind of automatic clinical chemistry analyzer with noncontact air pressure agitating device, instrument primary structure include reagent disc,
Specimen disc, reaction tray, detection device, detection cup clean device and noncontact air pressure agitating device.
Described reagent disc is used for placing reagent bottle;Described specimen disc is used for placing sample cell or specimen cup;Described reaction tray
For placing detection cup;Described detection device is for carrying out optical signal detecting to liquid in detection cup;Described detection cup cleans dress
Put for cleaning detection cup;
Described noncontact air pressure agitating device include air pump, pressure-regulating device, heating and attemperating unit, connecting tube and
First barostat;Air pump, for blasting air in the first barostat, produces impact air pressure;Pressure-regulating device is used for regulating
Air-flow size, speed and time in first barostat;Connecting tube is used for connecting air pump, the first barostat and pressure regulation dress
Put;Described first barostat, for the non-contacting liquid surface applying impact air pressure in local less than 50% in detection cup, drives
In making cup, liquid forms flowing due to pressure inequality, liquid in mixing detection cup;Described heating and attemperating unit include
Heater and radiator valve, heater and radiator valve are encircled and are arranged on the first barostat periphery, are respectively used to first
In barostat, gas carries out heating and keeping constant temperature.
In conjunction with Fig. 1 (a), described first barostat 1 is arranged on detection cup 2 ullage side, and the first barostat 1 is to liquid level
Form impact air pressure at 3, make local pressure at liquid level 3 be more than other parts, and declined by high-pressure section liquid level, localized liquid
Flow to area of low pressure, and relatively low pressure part liquid level rises due to other region liquid extruding so that the liquid in cup occurs
Flowing.
Stopping pressure in conjunction with Fig. 1 (b) when the first barostat, former local is reduced by high-pressure section pressure and recovers normal, liquid
Body refluxes;Fig. 1 (c) is liquid level position schematic diagram under normal condition.
Embodiment 2
In conjunction with Fig. 2 (a) and Fig. 2 (b), the present embodiment is provided with two barostats, the i.e. second barostat 4 and the 3rd barostat
5, lay respectively at ullage relative to position, mutual side barostat of opening forms impact air pressure;Fig. 2 (c) is under normal condition
Liquid level position schematic diagram.
Embodiment 3
In conjunction with Fig. 3, the present embodiment is with the difference of embodiment 1, uses the 4th barostat 6 to replace the first barostat 1, the
Four barostats 6 are arranged in the middle part of liquid level.Fig. 3 (a) is to detect liquid stream in cup after barostat produces impact air pressure in the middle part of liquid level
Dynamic schematic diagram, Fig. 3 (b) is that barostat stops liquid backflow schematic diagram after pressure, and Fig. 3 (c) shows for detecting liquid level in cup after stirring
It is intended to.
Embodiment 4
In conjunction with Fig. 4, the present embodiment is with the difference of embodiment 1, uses elbow barostat 7 to replace the first barostat 1, curved
Being elbow at head barostat 7 syringe needle, the impact air pressure of generation is horizontal by 45° angle.Fig. 4 (a) is that elbow barostat 7 is with 45 °
Angle detects liquid flow schematic diagram in cup after producing impact air pressure in the middle part of liquid level, and Fig. 4 (b) is that elbow barostat stops pressure
Rear liquid backflow schematic diagram, Fig. 4 (c) is for detecting liquid level schematic diagram in cup after stirring, Fig. 4 (d) is the top view of Fig. 4 (a).
Embodiment 5
In conjunction with Fig. 5, a kind of automatic clinical chemistry analyzer with noncontact air pressure agitating device of the present embodiment, analyser
Arranging 4 barostat stirring positions, instrument automatically needs according to detection, is added in the first reagent adding position by reagent one R1 in reagent disc 9
Enter in the detection cup 2 of reaction tray 11;Reaction tray 11 rotates automatically afterwards, and detection cup 2 is along with the rotation reach one of each reaction tray
Position, when detecting cup 2 and going to be loaded grade, sample S in specimen disc 8A is added reaction tray 11 and detects in cup 2 by instrument automatically;Instead
Should coil 11 continuation rotate and drive detection cup reach, when detecting cup and going to the first stirring position M1, barostat sprays in detection cup
Go out impact air-flow, by air-flow size, speed and time in pressure-regulating device regulation barostat;Impact air-flow is to liquid level one
Or multiple position forms impact air pressure, make detection cup liquid level form draught head, drive liquid flowing, to reagent one R1 in detection cup
Carrying out stirring for the first time with sample S, after stirring, barostat cleans device automatic purgative gas pressing;When detection cup goes to the second stirring
During the M2 of position, barostat carries out second time according to the same manner to reagent one R1 and sample S in detection cup and stirs, in order to fully mix
Liquid in detection cup, after stirring, barostat cleans device automatic purgative gas pressing.
Reaction tray 11 continues to rotate and drive detection cup reach, and when detecting cup and going to the second reagent adding position, instrument is automatic
Reagent two R2 in reagent disc 10 being added reaction tray 11 and detects in cup 2, reaction tray 11 continues to rotate and drive detection cup reach, when
When detection cup goes to the 3rd stirring position M3, reagent one R1, sample S and reagent two R2 in detection cup are carried out stirring for the first time by barostat
Mixing, after stirring, barostat cleans device automatic purgative gas pressing;When detecting cup and going to the 4th stirring position M4, barostat is to detection
In Bei, reagent one R1, sample S and reagent two R2 carry out stirring for the second time, and after stirring, barostat cleans device and automatically cleans air pressure
Pin.By detection device, mixing liquid in detection cup is carried out optical signal detecting, after detection, clean device by detection cup
Detection cup is carried out.
Embodiment 6
In conjunction with Fig. 5, the present embodiment is with the difference of embodiment 5, and analyser only arranges 2 barostats stirring positions, i.e. the
One stirring position M1 and the 3rd stirring position M3, when the detection cup equipped with reagent one R1 and the mixed liquor of sample S goes to the first stirring position
Once stirring during M1 position, the detection cup equipped with reagent one R1, sample S and reagent two R2 mixed liquor goes to the 3rd stirring position M3
Once stir during position.
Embodiment 7
In conjunction with Fig. 6, the present embodiment is with the difference of embodiment 5, and sample S, reagent one R1 and reagent two R2 share one
Dish 8B, sample, inner ring placement reagent are placed in outer ring.
Claims (10)
1. an automatic clinical chemistry analyzer with noncontact air pressure agitating device, it is characterised in that this analyser includes examination
Agent dish, specimen disc, reaction tray, detection device, detection cup clean device and noncontact air pressure agitating device;
Described reagent disc is used for placing reagent bottle;Described specimen disc is used for placing sample cell or specimen cup;Described reaction tray is used for
Place detection cup;Described detection device is for carrying out optical signal detecting to liquid in detection cup;Described detection cup cleans device and uses
In cleaning detection cup;
Described noncontact air pressure agitating device is made up of air pump, pressure-regulating device, connecting tube and barostat;
Described air pump is used for blasting air and being sprayed by barostat;
Described barostat is arranged on above detection cup, for non-contacting liquid surface applying impact air pressure in detection cup;
Described pressure-regulating device is for regulating air-flow size, speed and the time of barostat ejection;
Described connecting tube is for air pump, barostat and the connection of pressure-regulating device.
The automatic clinical chemistry analyzer with noncontact air pressure agitating device the most according to claim 1, it is characterised in that
Described barostat is more than 1, and is arranged at above same detection cup.
The automatic clinical chemistry analyzer with noncontact air pressure agitating device the most according to claim 1, it is characterised in that
Described barostat is more than 1, and each barostat is separately positioned on the top of instrument reaction tray difference detection cup position.
The automatic clinical chemistry analyzer with noncontact air pressure agitating device the most according to claim 1, it is characterised in that
This automatic clinical chemistry analyzer also includes cleaning device, for purgative gas pressing surfaces externally and internally.
The automatic clinical chemistry analyzer with noncontact air pressure agitating device the most according to claim 1, it is characterised in that
Described barostat exit flow direction is more than 30 degree with the angle in liquid level face.
The automatic clinical chemistry analyzer with noncontact air pressure agitating device the most according to claim 1, it is characterised in that
Pressure-regulating device is adjustable valve or adjustable pressure tank, is used for controlling barostat and continuously or discontinuously applies air pressure.
The automatic clinical chemistry analyzer with noncontact air pressure agitating device the most according to claim 1, it is characterised in that
Described noncontact air pressure agitating device also includes heating and attemperating unit, and described heating and attemperating unit include heater and constant temperature
Controller, is respectively used to heat gas in barostat and keep constant temperature.
The automatic clinical chemistry analyzer with noncontact air pressure agitating device the most according to claim 1, it is characterised in that
This automatic clinical chemistry analyzer also includes that barostat mobile device, described barostat mobile device are used for driving barostat in work
Shi Jinhang angle adjustment or move horizontally, by being sufficiently stirred for liquid to liquid level difference local pressure.
9. an analysis side based on the automatic clinical chemistry analyzer described in claim 1 with noncontact air pressure agitating device
Method, it is characterised in that the method comprises the following steps:
Step 1, analyser need according to detection, progressively reagent, sample are added in the detection cup in reaction tray;
Below step 2, mobile detection cup to barostat, barostat sprays impact air-flow in detection cup, and is regulated by pressure
Air-flow size, speed and time in device regulation barostat;Impact air-flow position one or more to liquid level forms impact air pressure,
Make detection cup liquid level form draught head, drive liquid flowing, complete to detect liquid agitation in cup;
Step 3, by detection device to detection cup in liquid carry out optical signal detecting;
Step 4, complete detection after, by detection cup clean device to detection cup be carried out, proceed next after cleaning and follow
The detection of ring.
The analysis method of the automatic clinical chemistry analyzer with noncontact air pressure agitating device the most according to claim 9,
It is characterized in that, barostat two group is arranged at the different loci of same detection cup position, two pinwheels when performing stirring
Stream jet body, i.e. during one of them barostat jet, another barostat stops jet.
Priority Applications (2)
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CN201610688975.7A CN106093445A (en) | 2016-08-17 | 2016-08-17 | There is automatic clinical chemistry analyzer and the analysis method of noncontact air pressure agitating device |
PCT/CN2017/070575 WO2018032719A1 (en) | 2016-08-17 | 2017-01-08 | Fully-automatic biochemical analyzer with non-contact pneumatic mixing device, and method of analysis |
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CN201610688975.7A CN106093445A (en) | 2016-08-17 | 2016-08-17 | There is automatic clinical chemistry analyzer and the analysis method of noncontact air pressure agitating device |
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CN201610688975.7A Pending CN106093445A (en) | 2016-08-17 | 2016-08-17 | There is automatic clinical chemistry analyzer and the analysis method of noncontact air pressure agitating device |
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Cited By (2)
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WO2018032719A1 (en) * | 2016-08-17 | 2018-02-22 | 江苏英诺华医疗技术有限公司 | Fully-automatic biochemical analyzer with non-contact pneumatic mixing device, and method of analysis |
CN112624684A (en) * | 2020-10-26 | 2021-04-09 | 西安科技大学 | Electrochromic concrete brick and production process and manufacturing equipment thereof |
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CN113311111B (en) * | 2021-05-18 | 2022-10-11 | 内蒙古显鸿科技股份有限公司 | Atmospheric pollutant concentration prediction method and system combining machine learning and LSTM |
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CN112624684B (en) * | 2020-10-26 | 2022-05-20 | 西安科技大学 | Electrochromic concrete brick and production process and manufacturing equipment thereof |
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Application publication date: 20161109 |