CN106010807B - A kind of multienzyme cleaning agent for stain on medical instrument - Google Patents
A kind of multienzyme cleaning agent for stain on medical instrument Download PDFInfo
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- CN106010807B CN106010807B CN201610400692.8A CN201610400692A CN106010807B CN 106010807 B CN106010807 B CN 106010807B CN 201610400692 A CN201610400692 A CN 201610400692A CN 106010807 B CN106010807 B CN 106010807B
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/72—Ethers of polyoxyalkylene glycols
- C11D1/721—End blocked ethers
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/02—Inorganic compounds ; Elemental compounds
- C11D3/04—Water-soluble compounds
- C11D3/042—Acids
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- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/02—Inorganic compounds ; Elemental compounds
- C11D3/04—Water-soluble compounds
- C11D3/046—Salts
- C11D3/048—Nitrates or nitrites
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/02—Inorganic compounds ; Elemental compounds
- C11D3/04—Water-soluble compounds
- C11D3/06—Phosphates, including polyphosphates
- C11D3/075—Phosphates, including polyphosphates in admixture with ethers of polyoxyalkylenes
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2075—Carboxylic acids-salts thereof
- C11D3/2086—Hydroxy carboxylic acids-salts thereof
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2096—Heterocyclic compounds
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/22—Carbohydrates or derivatives thereof
- C11D3/221—Mono, di- or trisaccharides or derivatives thereof
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/26—Organic compounds containing nitrogen
- C11D3/33—Amino carboxylic acids
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/382—Vegetable products, e.g. soya meal, wood flour, sawdust
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- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38627—Preparations containing enzymes, e.g. protease or amylase containing lipase
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
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Abstract
The present invention discloses a kind of multienzyme cleaning agent for stain on medical instrument, belongs to medical cleaning agent technical field.Include following component by weight：5~10 parts of complex enzyme, 10~15 parts of soapberry extract, 10~15 parts of Tea Saponin, 3~5 parts of Ginger P.E, 5~7 parts of vitamin E, 2~4 parts of 1,5 D anhydrofructoses, 15~20 parts of EDTA, 5~10 parts of citric acid, 3~5 parts of phosphoric acid, 3~5 parts of nonionic surfactant, 1~3 part of essence, 1~3 part of antifoaming agent, 1~3 part of preservative, 50~80 parts of water.The cleaning agent of the application has the advantages that cleaning speed is fast, cleaning performance is good in the cleaning applied to medical instrument.
Description
Technical field
The present invention discloses a kind of multienzyme cleaning agent for stain on medical instrument, belongs to medical cleaning agent technology neck
Domain.
Background technology
Cleaning is a most important link in the entire workflow of disinfection and supply center.Because the quality of instrument cleaning is straight
It connects and is related to sterilizing article quality, the percentage of sterilizing directly influences entire medical safety.Cleaning refers to remove Medical treatment device
The dirt of tool, utensil and article surface attachment（Bag expands blood, tissue, protein etc.）And the process of part microorganism.Cleaning is gone
The object removed：Protein, carbohydrate, hemoglobin, lipid, inorganic ions, microbial load, endotoxin etc..Effectively
Cleaning process comprise the following steps：First step：It rinses：Finger is cleaned with circulating water, removal instrument, utensil and article table
The process of face dirt.Cleaning under circulating water can effectively remove dirt.Second step：Washing：Refer to using cleaning agent, breast
The process of change, decomposition and separating apparatus surface contaminants.Third step rinses：Wash what cleaned agent dispersed out with circulating water
Pollutant and the remaining process of chemical cleaning machine.Dirt is prevented to be deposited in the surface of cleaned equipment again, ensures the clear of equipment
Cleanliness.Four steps end rinsing eventually：End rinsing is used for the cleaning step of mechanical cleaning precision equipment eventually.End rinsing eventually is last
The step of a cleaning, should select soft water, purified water or distilled water to be rinsed, and can further improve equipment degree.
CN105385512A discloses a kind of low bubble Multi-enzyme detergent and its preparation process for medical instrument cleaning, by gathering
Ethylene glycol, enzyme stabilizers, boric acid, borax, chelating agent, triethanolamine, neutral hydrolysising protease, lipase, amylase, cellulose
Enzyme, marine protein enzyme, lysozyme, trehalose, light blue pigment, preservative and water composition.CN104962402A discloses one kind
Medical instrument and equipment for washing agent more particularly to a kind of preparation method of all-round efficient medical Multi-enzyme detergent.It is a kind of all-round high
Imitating medical Multi-enzyme detergent, it includes following ingredients：Alkyl glycosides 10-15%；Didecyl Dimethy ammonium chloride 1-4%；Silicic acid
Sodium 1-10%；Amylase 4-8%；Cellulase 5-8%；Lipase 2-5%；Protease 5-12%；Add deionized water extremely
100%.The all-round efficient medical Multi-enzyme detergent its preparation method is first to add in 30% deionized water in agitator tank,
Sequentially add alkyl glycosides 10-15%；Didecyl Dimethy ammonium chloride 1-4%；It is sufficiently stirred 10 minutes, then by sodium metasilicate 1-
10% plus deionized water dissolving, it adds in agitator tank and continues stirring 5 minutes, then by amylase 4-8%；Cellulase 5-8%；Fat
Enzyme 2-5%；Protease 5-12% continues stirring 10 minutes, and deionized water is added to continue stirring 10 minutes to 100% to get described
All-round efficient medical Multi-enzyme detergent.
But above-mentioned cleaning agent is directed to after being placed for a long time on medical instrument and forms more stain presence
The problem of detergency is bad.
The content of the invention
The purpose of the present invention is：For on medical instrument for a long time place after form more stain, it is proposed that one
Kind is with the cleaning agent that cleaning speed is fast, cleaning speed is good.
Technical solution is：
A kind of multienzyme cleaning agent for stain on medical instrument includes following component by weight：It is multiple
5~10 parts of synthase, 10~15 parts of soapberry extract, 10~15 parts of Tea Saponin, 3~5 parts of Ginger P.E, vitamin E 5~7
Part, 2~4 parts of 1,5-D- anhydrofructoses, 15~20 parts of EDTA, 5~10 parts of citric acid, 3~5 parts of phosphoric acid, non-ionic surface active
3~5 parts of agent, 1~3 part of essence, 1~3 part of antifoaming agent, 1~3 part of preservative, 50~80 parts of water.
The complex enzyme refers to protease, amylase, lipase according to weight ratio 1：（2~4）：（2~4）Mixing and
Into.
The soapberry extract and/or Ginger P.E is after being extracted, dried as solvent using water or alcohol
It obtains.
The nonionic surfactant is selected from polyethylene glycol oxide hexyl ether, polyoxyethylene octyl ether, polyoxyethylene
One or several kinds of mixing in alkene decyl ethers, polyoxyethylene lauryl ether or polyethylene glycol oxide cetyl ether.
One or several kinds of the antifoaming agent in mineral oil defoaming agent, non-silicone class antifoaming agent are mixed
It closes.
One or several kinds of the preservative in potassium citrate, calgon or nitrite are mixed
It closes.
The preparation method of above-mentioned multienzyme cleaning agent, includes the following steps：After each component is uniformly mixed, 40 are warming up to
~45 DEG C, stir 1~2h after to get.
Advantageous effect
Tea Saponin is extracted and obtained from tea seed cake of the tea seed after machinery extracts oil, and structure belongs to triterpenoid saponin,
Pentacyclic triterpenoid is formed by sugared body, aglucon and organic acid.Average molecular formula C57H90O26, relative molecular mass is
1200~2800.Hydroxyl on aglycon and organic acid form ester, and also strong electronegativity oxygen-containing group (such as-O- ,-OH ,-
COOH ,-COO-), these hydrophilic radicals are concentrated between the saccharide ligand of Tea Saponin, organic acid ligand and saponin(e connecting portion；
And lipophilic group is made of nonpolar hydrocarbon loop chain.In this application, it acts synergistically with soapberry extract, promotes doctor
The removing of the obstinate bloodstain on instrument is treated, additionally by vitamin E is added in, is still maintained after cleaning agent storage for a long time can be made
Preferable cleaning performance.The cleaning agent of the application has that cleaning speed is fast, cleaning performance in the cleaning applied to medical instrument
The advantages of good.
Specific embodiment
Multienzyme cleaning agent provided by the invention for stain on medical instrument includes by weight as follows
Component：5~10 parts of complex enzyme, 10~15 parts of soapberry extract, 10~15 parts of Tea Saponin, 3~5 parts of Ginger P.E, dimension life
Plain 5~7 parts of E, 2~4 parts of 1,5-D- anhydrofructoses, 15~20 parts of EDTA, 5~10 parts of citric acid, 3~5 parts of phosphoric acid, nonionic
3~5 parts of surfactant, 1~3 part of essence, 1~3 part of antifoaming agent, 1~3 part of preservative, 50~80 parts of water.
Wherein, the complex enzyme refers to protease, amylase, lipase according to weight ratio 1：（2~4）：（2~4）It is mixed
It closes.
Tea Saponin is extracted and obtained from tea seed cake of the tea seed after machinery extracts oil, and structure belongs to triterpenoid saponin,
Pentacyclic triterpenoid is formed by sugared body, aglucon and organic acid.Average molecular formula C57H90O26, relative molecular mass is
1200~2800.Hydroxyl on aglycon and organic acid form ester, and also strong electronegativity oxygen-containing group (such as-O- ,-OH ,-
COOH ,-COO-), these hydrophilic radicals are concentrated between the saccharide ligand of Tea Saponin, organic acid ligand and saponin(e connecting portion；
And lipophilic group is made of nonpolar hydrocarbon loop chain.In this application, it acts synergistically with soapberry extract, promotes doctor
The removing of the obstinate bloodstain on instrument is treated, additionally by vitamin E is added in, is still maintained after cleaning agent storage for a long time can be made
Preferable cleaning performance.
In addition, it can also coordinate essence.As essence, it is preferable to use the oil such as one kind or two or more natural essence, compound essence
Fat essence and powdered flavor, but be not particularly limited.For example, natural essence can be enumerated：Frankincense oil, parsley oil, oleum anisi, folium eucalypti
Oil, wintergreen, cinnamon oil, menthol oil, oleum menthae viridis, peppermint oil, lemon oil, coriander oil, orange-seed oil, mandarin oil, lime oil,
Lavender oil, oreodaphene, chamomile oil, cardamom oil, caraway oil, bay tree leaf oil, lemongrass oil, pinke needle oil, neroli oil, rose
Common vetch oil, jasmine oil, iris flower concrete, Peppermint essential oil, rose essential oil, citrus flower, tangerine oil, mixed fruit oil, arbusterol, Ceylon
Cinnamon oil, caryophyllus oil, grapefruit etc..As simple essence, can enumerate：Carvol, anethole, gaultherolin, cinnamic acid, virtue
Camphor tree alcohol, linalyl-acetate, limonene, menthones, menthyl acetate, sobrerone, octanal, citral, pulegone, acetic acid Sheep's-parsley
Ester, anisaldehyde, ethyl acetate, ethyl butyrate, hexamethylene allyl propionate, Anthranilate, ethyl ortho-aminobenzoic acid
Salt, vanilione, undecalactone, hexanal, ethyl alcohol, propyl alcohol, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, methyl cyclopentene alcohol
Ketone, furfural, trimethylpyrazine, ethyl lactate, ethyl thioacetate etc..As containing simple essence and/or containing natural
The mixing essence of essence, can enumerate：Strawberry perfume, apple perfume, banana incense, pineapple is fragrant, grape is fragrant, mango is fragrant, tropical fruit (tree) is fragrant, yellow
Salted cake fried in sesame oil, milk, Yoghourt are fragrant, fruit mixes perfume, dried peppermint leaf perfume (or spice) etc..In addition, the form of essence have essential oil, extract, solids,
Can be that they are spray-dried to obtained powder.
Nonionic surfactant in component includes, for example, line style polyoxyalkylene alkyl class, as polyethylene glycol oxide oneself
Base ether, polyoxyethylene octyl ether, polyethylene glycol oxide decyl ethers, polyoxyethylene lauryl ether and polyethylene glycol oxide cetyl
Ether；Branched polyoxyalkylenes primary alkyl ethers, such as polyethylene glycol oxide 2- ethylhexyl ethers, polyethylene glycol oxide isocetyl ether and
Polyethylene glycol oxide iso stearyl ether；Branched polyoxyalkylene secondary alkyl ethers, such as polyethylene glycol oxide 1- hexyl hexyl ethers, polyoxyethylene
Alkene 1- octyl group hexyl ethers, polyethylene glycol oxide 1- hexyl Octyl Ethers, polyethylene glycol oxide 1- amyl heptyl ethers and polyethylene glycol oxide 1- heptan
Base amyl ether；Polyoxyalkylene alkenyl ethers class, such as polyethylene glycol oxide oleyl ether；Polyoxyalkylene alkyl phenyl ethers, such as polyoxy
Change ethylene octyl phenyl ether, polyoxyethylene nonylplenyl ether and polyethylene glycol oxide dodecylphenyl ether；Polyoxyalkylene alkyl
Aryl phenyl ethers, such as polyethylene glycol oxide tri-styryl phenyl ether, polyethylene glycol oxide diphenylethyllene phenyl ether, polyoxyethylene
Alkene styrylphenyl ether, polyethylene glycol oxide tribenzyl phenyl, polyethylene glycol oxide dibenzylphenyl ether and polyethylene glycol oxide benzyl
Base phenyl ether；Polyoxyalkylene fatty acid ester class, such as polyethylene glycol oxide monolaurate, polyethylene glycol oxide monoleate, polyoxygenated
Ethylene monostearate, polyethylene glycol oxide list myristinate, polyethylene glycol oxide dilaurate, two oleic acid of polyethylene glycol oxide
Ester, two myristinate of polyethylene glycol oxide and polyethylene glycol oxide distearate；Sorbitan ester class is such as dehydrated mountain
Pears monoplamitate and dehydrated sorbitol mono-fatty acid ester；Polyoxyalkylene sorbitan polyol fatty acid esters, such as polyoxy
Change ethylene sorbitan monostearate and polyoxyethylene sorbitan monoleate；Glycerine fatty acid esters,
Such as glyceryl monostearate, glyceryl monolaurate and glycerol monopalmitate；Polyoxyalkylene sorbitan polyol fatty acid esters；Sugarcane
Sugar fatty acid esters；Polyoxyalkylene castor oil ethers, such as polyoxyethylene castor oil ether；Polyoxyalkylene hydrogenated castor oil ethers,
Such as polyoxyethylene hydrogenated castor oil ether；Polyoxyalkylene alkyl amino ethers, such as polyoxyethylene lauryl base amino ethers and polyoxy
Change ethylene stearyl ether；Ethylene oxide-propylene oxide block or random copolymer；The ethylene oxide of end alkyl etherificate
Base-oxypropylene group block or random copolymer；With the ethylene oxide-propylene oxide block or random common of end sucrose-etherificate
Polymers.
Using antifoaming agent bottom line is arrived to prevent or reduce blistering.Various disappear can be used for this purpose
Infusion.Several antifoaming agent for being commercially available suitable for the present composition are：Mineral oil defoaming agent (for example, by
Colloids 643TM, the Colloids 640TM and Colloids 647TM that Colloid Ind. are obtained)；Non-silicone
Class antifoaming agent (for example, Interfoam XI-7TM, can be obtained by AKZO Inc.)；Nonionic surfactant and petroleum hydrocarbon
Admixture (for example, the Foamaster VLTM obtained by Diamond Shamrock Corp.)；The clear bubble that stearate is modified
Agent is (for example, by Ultra Ad- hesive Inc. Dee-Fo 918TM, the Dee-Fo 233TM obtained and Dee-Fo 97-
3TM)。
The non-limiting example of preservative in the preparation compositions of the present invention includes：Acetic acid, citric acid, benzoic acid, mountain
Pears acid, sulfur dioxide, Potassium Benzoate, potassium sorbate, sodium benzoate, sodium sorbate, calcium benzoate, calcium sorbate, citric acid
Sodium, potassium citrate, calgon, nitrite, sulphite, etc..Preservative may also include such as ascorbic acid,
EDTA, BHA, BHT, TBHQ, acetic anhydride, two dimethyl carbonates, ethoxyquin and p-hydroxybenzoate etc it is anti-oxidant
Agent.
Above-mentioned soapberry extract and/or Ginger P.E can be by being impregnated in solvent simultaneously by raw material soapberry and ginger
The concentrate obtained after being filtered, depressurize and concentrating after extraction.Above-mentioned solvent can be water, C1~C4 it is anhydrous or aqueous
Alcohol, acetate fiber, glycerine, the mixture of propylene glycol and the one or more in propylene glycol, but not limited to this.Extraction can
To be carried out by being stored at room temperature, but can be as desired by heating, stir, be heated to reflux promoting to extract.Gained carries
It is used after taking liquid that can directly use or implementing the processing such as suitably filtering, concentration, decoloration.It is it is further possible to molten temporarily removing
After agent, used after being redissolved in the solvent different from extracting solvent used.The extract of gained can also be led to
It crosses after activated carbon, column chromatography etc. are further purified and uses.
The preparation of 1 soapberry extract of implementation column and/or Ginger P.E
The mode that following ethyl alcohol extraction may be employed extracts the ingredient of soapberry and ginger.
The soapberry of crushing and ginger 100g are impregnated in 50% ethyl alcohol respectively（v/v）500g, under 60 DEG C of temperature conditionss
Carry out 3 it is small when heat circulation extraction, filtering and decompression, be concentrated and dried, respectively obtain 9g and 11g extract powders.
Embodiment 2
Weigh following raw material by weight：5 parts of complex enzyme, 10 parts of soapberry extract, 10 parts of Tea Saponin, ginger carry
Take 3 parts of object, 5 parts of vitamin E, 2 parts of 1,5-D- anhydrofructoses, 15 parts of EDTA, 5 parts of citric acid, 3 parts of phosphoric acid, polyethylene glycol oxide
3 parts of Octyl Ether, 1 part of essence, 1 part of mineral oil antifoam agent, 1 part of preservative calgon, 50 parts of water；The complex enzyme refers to
Protease, amylase, lipase are according to weight ratio 1：2：2 mix.
Preparation method：After each component is uniformly mixed, be warming up to 40 DEG C, stir after 1h to get.
Embodiment 3
Weigh following raw material by weight：10 parts of complex enzyme, 15 parts of soapberry extract, 15 parts of Tea Saponin, ginger
5 parts of extract, 7 parts of vitamin E, 4 parts of 1,5-D- anhydrofructoses, 20 parts of EDTA, 10 parts of citric acid, 5 parts of phosphoric acid, polyoxyethylene
5 parts of alkene Octyl Ether, 3 parts of essence, 3 parts of mineral oil antifoam agent, 3 parts of preservative calgon, 80 parts of water；The complex enzyme is
Finger protein enzyme, amylase, lipase are according to weight ratio 1： 4：4 mix.
Preparation method：After each component is uniformly mixed, be warming up to 50 DEG C, stir after 2h to get.
Embodiment 4
Weigh following raw material by weight：9 parts of complex enzyme, 13 parts of soapberry extract, 12 parts of Tea Saponin, ginger carry
Take 4 parts of object, 6 parts of vitamin E, 3 parts of 1,5-D- anhydrofructoses, 18 parts of EDTA, 8 parts of citric acid, phosphatase 24 part, polyethylene glycol oxide
4 parts of Octyl Ether, 2 parts of essence, 2 parts of mineral oil antifoam agent, 2 parts of preservative calgon, 70 parts of water；The complex enzyme refers to
Protease, amylase, lipase are according to weight ratio 1：3：3 mix.
Preparation method：After each component is uniformly mixed, be warming up to 45 DEG C, stir after 2h to get.
Reference examples 1
With embodiment 4 difference lies in：Tea Saponin be by etc. weight soapberry extract replace.
Weigh following raw material by weight：9 parts of complex enzyme, 25 parts of soapberry extract, 4 parts of Ginger P.E, dimension
Raw 6 parts of element E, 3 parts of 1,5-D- anhydrofructoses, 18 parts of EDTA, 8 parts of citric acid, phosphatase 24 part, 4 parts of polyoxyethylene octyl ether,
2 parts of essence, 2 parts of mineral oil antifoam agent, 2 parts of preservative calgon, 70 parts of water；The complex enzyme refers to protease, forms sediment
Powder enzyme, lipase are according to weight ratio 1：3：3 mix.
Preparation method：After each component is uniformly mixed, be warming up to 45 DEG C, stir after 2h to get.
Reference examples 2
With embodiment 4 difference lies in：Soapberry extract be by etc. weight Tea Saponin replace.
Weigh following raw material by weight：9 parts of complex enzyme, 25 parts of Tea Saponin, 4 parts of Ginger P.E, vitamin E 6
Part, 3 parts of 1,5-D- anhydrofructoses, 18 parts of EDTA, 8 parts of citric acid, phosphatase 24 part, 4 parts of polyoxyethylene octyl ether, 2 parts of essence,
2 parts of mineral oil antifoam agent, 2 parts of preservative calgon, 70 parts of water；The complex enzyme refers to protease, amylase, fat
Enzyme is according to weight ratio 1：3：3 mix.
Preparation method：After each component is uniformly mixed, be warming up to 45 DEG C, stir after 2h to get.
Reference examples 3
With embodiment 4 difference lies in：Vitamin E is not added in.
Weigh following raw material by weight：9 parts of complex enzyme, 13 parts of soapberry extract, 12 parts of Tea Saponin, ginger carry
Take 4 parts of object, 3 parts of 1,5-D- anhydrofructoses, 18 parts of EDTA, 8 parts of citric acid, phosphatase 24 part, 4 parts of polyoxyethylene octyl ether, perfume
2 parts of essence, 2 parts of mineral oil antifoam agent, 2 parts of preservative calgon, 70 parts of water；The complex enzyme refers to protease, starch
Enzyme, lipase are according to weight ratio 1：3：3 mix.
Preparation method：After each component is uniformly mixed, be warming up to 45 DEG C, stir after 2h to get.
Cleaning performance is tested：
Mouse is taken into blood, mouse blood, starch, water 1 by weight：0.1：1.5 after mixing, and note gauze soaks
Afterwards, smear on stainless steel, then by stainless steel plate be positioned over 30 DEG C, humidity to place 72h in the environment of 40%RH, take out
It is soaked in afterwards in above-described embodiment and the cleaning agent of reference examples, it is 25 DEG C to keep cleaning agent temperature, and stainless steel plate is disposed vertically, and is put
It was found that when bloodstain comes off, the time is recorded, each test group is repeated 10 times, and calculates average value.
The bloodstain of each embodiment and reference examples comes off time such as following table：
| Embodiment 2 | Embodiment 3 | Embodiment 4 | Reference examples 1 | Reference examples 2 | Reference examples 3 | |
| Time min | 14.32 | 14.10 | 13.59 | 21.26 | 19.57 | 15.21 |
As can be seen from the table, Tea Saponin and the reference examples 1 of soapberry extract and when coming off of reference examples 2 is used alone
Between longer than simultaneously using the embodiment 4 of Tea Saponin and soapberry extract, illustrate that Tea Saponin and soapberry extract make simultaneously
Used time can generate synergistic effect, accelerate coming off the time for bloodstain.
In addition, above-mentioned cleaning agent is placed in vial, further takes out and carry out after being placed 6 months at 30 DEG C of the place of being protected from light
Cleaning experiment is stated, it is as a result as follows：
| Embodiment 2 | Embodiment 3 | Embodiment 4 | Reference examples 1 | Reference examples 2 | Reference examples 3 | |
| Time min | 16.46 | 16.57 | 17.51 | 31.22 | 29.27 | 38.78 |
As can be seen from the table, embodiment 4 is for reference examples 3, can be effectively by adding vitamin E
Extend the validity date of cleaning agent, preferable cleaning performance is maintained to after long-term place.
Claims (7)
1. a kind of multienzyme cleaning agent for stain on medical instrument, it is characterised in that：Include by weight as
Lower component：5~10 parts of complex enzyme, 10~15 parts of soapberry extract, 10~15 parts of Tea Saponin, 3~5 parts of Ginger P.E, dimension
Raw 5~7 parts of element E, 2~4 parts of 1,5-D- anhydrofructoses, 15~20 parts of EDTA, 5~10 parts of citric acid, 3~5 parts of phosphoric acid, it is non-from
Sub- 3~5 parts of surfactant, 1~3 part of essence, 1~3 part of antifoaming agent, 1~3 part of preservative, 50~80 parts of water.
2. the multienzyme cleaning agent according to claim 1 for stain on medical instrument, it is characterised in that：Described
Complex enzyme refers to protease, amylase, lipase according to weight ratio 1：（2~4）：（2~4）It mixes.
3. the multienzyme cleaning agent according to claim 1 for stain on medical instrument, it is characterised in that：Described
Soapberry extract and/or Ginger P.E obtain after being extracted, dried as solvent using water or alcohol.
4. the multienzyme cleaning agent according to claim 1 for stain on medical instrument, it is characterised in that：Described
Nonionic surfactant is selected from polyethylene glycol oxide hexyl ether, polyoxyethylene octyl ether, polyethylene glycol oxide decyl ethers, polyoxygenated
One or several kinds of mixing in ethylene lauryl ether or polyethylene glycol oxide cetyl ether.
5. the multienzyme cleaning agent according to claim 1 for stain on medical instrument, it is characterised in that：Described
Antifoaming agent is selected from mineral oil defoaming agent.
6. the multienzyme cleaning agent according to claim 1 for stain on medical instrument, it is characterised in that：Described
One or several kinds of mixing of the preservative in potassium citrate, calgon or nitrite.
7. any preparation method for the multienzyme cleaning agent of stain on medical instrument of claim 1~6, special
Sign is：Include the following steps：After each component is uniformly mixed, be warming up to 40~45 DEG C, stir after 1~2h to get.
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| CN106635461A (en) * | 2016-11-29 | 2017-05-10 | 长安大学 | Medical instrument cleaner and preparation method thereof |
| CN106947614A (en) * | 2017-03-22 | 2017-07-14 | 安徽民泰医药科技有限公司 | Blood cell analysis cleaning fluid |
| CN107937164A (en) * | 2017-11-13 | 2018-04-20 | 付辰 | A kind of complex cleaning and washing agent for medical instrument and preparation method thereof |
| CN109736081B (en) * | 2019-03-12 | 2021-06-29 | 合肥市第二人民医院 | Preparation method of natural blood stain wiping fiber |
| CN115141851B (en) * | 2022-08-12 | 2023-06-30 | 江苏雪豹日化有限公司 | Kitchen degreasing detergent and preparation method and application thereof |
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| JPH0386799A (en) * | 1989-08-29 | 1991-04-11 | Taiyo Koryo Kk | Food detergent |
| AUPQ679100A0 (en) * | 2000-04-07 | 2000-05-11 | Novapharm Research (Australia) Pty Ltd | Process and composition for cleaning medical instruments |
| CN1294246C (en) * | 2001-10-08 | 2007-01-10 | 邬静文 | Endoscope cleaning liquor and cleaning method |
| CN101311257B (en) * | 2007-05-25 | 2011-10-26 | 上海利康消毒高科技有限公司 | Liquid multienzyme detergent and method for preparing same |
| CN101921671B (en) * | 2010-08-12 | 2013-12-11 | 陕西嘉洁医疗消毒用品有限公司 | Bio-enzyme cleaning agent for medical apparatuses and preparation method thereof |
| CN102453631A (en) * | 2010-11-02 | 2012-05-16 | 郑州大学 | Medical liquid multienzyme detergent |
| CN103865663B (en) * | 2012-12-12 | 2016-09-07 | 深圳市芭格美生物科技有限公司 | Multienzyme cleaning agent for medical purpose and preparation method thereof |
| US8835370B2 (en) * | 2013-08-05 | 2014-09-16 | Greenology Products, Inc. | Organic cleaning composition |
| CN103881838B (en) * | 2014-03-07 | 2016-09-21 | 北京林业大学 | Fructus Sapindi Mukouossi fluid composition, dish washing detergent containing Fructus Sapindi Mukouossi fluid composition |
| CN103952245A (en) * | 2014-04-24 | 2014-07-30 | 宁德师范学院 | Natural detergent and preparation method and application thereof |
| CN104342300A (en) * | 2014-10-19 | 2015-02-11 | 无棣华信石油技术服务有限公司 | Special degradable cleaning powder for oil storage tank and preparation method thereof |
| CN104789386A (en) * | 2014-12-31 | 2015-07-22 | 吕鹏飞 | A natural environmental-friendly tableware detergent |
| CN104958224A (en) * | 2015-07-24 | 2015-10-07 | 傅兴琴 | Preparation method of traditional Chinese medicinal degreasing liquid shampoo |
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Effective date of registration: 20180419 Address after: Ganjingzi City District of Dalian City, Liaoning province 116000 Camp Street Village after Applicant after: Dalian Lane Medical Industry Co., Ltd. Address before: 644302, a group of Changfeng Village, ancient town, Changning County, Yibin, Sichuan Applicant before: Song Jiezhen |
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