CN105902494A - Novel air cooling spray and using method thereof - Google Patents
Novel air cooling spray and using method thereof Download PDFInfo
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- CN105902494A CN105902494A CN201610398581.8A CN201610398581A CN105902494A CN 105902494 A CN105902494 A CN 105902494A CN 201610398581 A CN201610398581 A CN 201610398581A CN 105902494 A CN105902494 A CN 105902494A
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- functional component
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- pentafluoropropane
- novel air
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Insects & Arthropods (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a novel air cooling spray. The spray is prepared from, by weight, 80-94% of 1,1,1,3,3-perfluoropropane, 0.1-20% of R-134a and 0.2-3% of mepivacaine. The precise components of 1,1,1,3,3-perfluoropropane, R-134a and mepivacaine are utilized, the good effect on local anaesthesia is achieved, and no any toxic or side effect exists.
Description
Technical field
The present invention relates to topical anesthesia field, be specifically related to a kind of Novel air cold spray agent and using method thereof.
Background technology
Intramuscular injection be children's ill time conventional a kind of medication.Typically it is usually used in that medicine should not be administered orally, sick child can not be administered orally
Medicine, or the when of needing quick medicament effect according to the state of an illness.Generally, intramuscular injection is performed by nurse, but because flesh
The pain that meat injection brings makes child be difficult to coordinate nurse, is mostly required for the head of a family and assists.And pain when injecting is to child
Bring the feared state of mind to hospital and nurse.How to realize the direction that Painless intramuscular injection sense is medicine research and development at present, current fiber crops
Liquor-saturated dose is by injection mostly, and persistent period long risk is relatively big, and the intramuscular injection time is short, and the anesthesia of needs only local has 5
Minute effect.
The general nurse of slight skin injury can use ethanol or hydrogen peroxide disinfection, then simple dressing, such place
On the one hand reason mode is that when cleaning, pain is strong, secondly, recovers all to regulate voluntarily by human body, and the time is longer.If can be clearly
Local anesthesia when bathing a wound, and have the medicament promoting wound healing, it will welcome by patient.
Summary of the invention
It is an object of the invention to reduce or avoid the pain in intramuscular injection or slight wound processing procedure, it is provided that a kind of novel air cooling is sprayed
Mist agent and using method thereof.
For realizing the purpose of the present invention, the invention provides techniques below scheme:
A kind of Novel air cold spray agent, functional component includes 1,1,1,3,3 ,-pentafluoropropane, R-134a and mepivacaine, weight
Score ratio is as follows:
1,1,1,3,3 ,-pentafluoropropane 80-94%；
R-134a 0.1-20%；
Mepivacaine 0.2-3%.
The preferred weight portion rate of each component is:
1,1,1,3,3 ,-pentafluoropropane 84-94%；
R-134a 0.1-15%；
Mepivacaine 0.2-2%.
Described functional component also includes the ethanol extraction of the dry polypide of periplaneta americana.
When the ethanol extraction of the dry polypide of described periplaneta americana extracts, the w/v of periplaneta americana and ethanol is 20:5-15, carries
Taking liquid and accounting for the weight fraction of functional component is 3-5%.
Functional component also includes the glycerol that weight fraction is 2-8%.
It is a further object of the present invention to provide the using method of a kind of Novel air cold spray agent: concrete scheme is as follows:
The using method of a kind of Novel air cold spray agent, loads pressure after being mixed by the ethanol solution of functional component and weight fraction 75%
Power inhalator jar, low tempertaure storage or spraying 2-8 second at skin 3-10cm, then intravenous injection or wrapping wound at the spraying of skin
Mouthful, patient is without pain.
It is an advantage of the current invention that:
1, the present invention utilizes clear and definite composition 1, and 1,1,3,3 ,-pentafluoropropane, R-134a and mepivacaine, local anesthesia there is is pole
Good effect, and without any side effects.
The ethanol extraction of the dry polypide of periplaneta americana that 2, the present invention is additionally added, both can extend the time of local anesthesia, it is also possible to
Promote the recovery of wound.
3, the present invention adds glycerol, to human body without any murder by poisoning, and improves skin penetration power and the volatility of mepivacaine, carries
High anaesthetic effect.
Detailed description of the invention
In order to illustrate in greater detail the present invention, be given and following prepare example.But the scope of the present invention is not limited thereto.
Embodiment 1,
Functional component configures 20% solution by following mass fraction: 1,1,1,3,3 ,-pentafluoropropane 80%；R-134a 18%；First piperazine card
Because of 2%, add the ethanol solution of the weight fraction 75% of 4 times of functional component weight.The solution configured is loaded pressure aerosol
Tank.
Embodiment 2
Functional component configures 10% solution by following mass fraction: 1,1,1,3,3 ,-pentafluoropropane 84%；R-134a 15%；First piperazine
Caine 1%, adds the ethanol solution of the weight fraction 75% of 9 times of functional component weight.The solution configured is loaded pressure gas
Mist tank.
Embodiment 3
Functional component configures 10% solution by following mass fraction: 1,1,1,3,3 ,-pentafluoropropane 86%；R-134a 12%；First piperazine
Caine 2%, adds the ethanol solution of the weight fraction 75% of 9 times of functional component weight.The solution configured is loaded pressure gas
Mist tank.
Embodiment 4
Functional component configures 10% solution by following mass fraction: 1,1,1,3,3 ,-pentafluoropropane 88%；R-134a 11%；First piperazine
Caine 1%, adds the ethanol solution of the weight fraction 75% of 9 times of functional component weight.The solution configured is loaded pressure gas
Mist tank.
Embodiment 5
Functional component configures 10% solution by following mass fraction: 1,1,1,3,3 ,-pentafluoropropane 90%；R-134a 8%；First piperazine
Caine 2%, adds the ethanol solution of the weight fraction 75% of 9 times of functional component weight.The solution configured is loaded pressure gas
Mist tank.
Embodiment 6
Functional component configures 5% solution by following mass fraction: 1,1,1,3,3 ,-pentafluoropropane 94%；R-134a 5%；First piperazine card
Because of 1%, add the ethanol solution of the weight fraction 75% of 19 times of functional component weight.The solution configured is loaded pressure aerosol
Tank.
Embodiment 7
Functional component configures 20% solution by following mass fraction: 1,1,1,3,3 ,-pentafluoropropane 80%；R-134a 15%；First piperazine card
Because of 1%；The ethanol extraction 4% of the dry polypide of periplaneta americana, the ethanol of the weight fraction 75% adding 4 times of functional component weight is molten
Liquid.The solution configured is loaded pressure inhalator jar.
Embodiment 8
Functional component configures 10% solution by following mass fraction: 1,1,1,3,3 ,-pentafluoropropane 84%；R-134a 10%；First piperazine card
Because of 1%；The ethanol extraction 5% of the dry polypide of periplaneta americana, the ethanol of the weight fraction 75% adding 9 times of functional component weight is molten
Liquid.The solution configured is loaded pressure inhalator jar.
Embodiment 9
Functional component configures 10% solution by following mass fraction: 1,1,1,3,3 ,-pentafluoropropane 86%；R-134a 10%；First piperazine
Caine 1%；The ethanol extraction 3% of the dry polypide of periplaneta americana, adds the ethanol of the weight fraction 75% of 9 times of functional component weight
Solution.The solution configured is loaded pressure inhalator jar.
Embodiment 10
Functional component configures 10% solution by following mass fraction: 1,1,1,3,3 ,-pentafluoropropane 88%；R-134a 5%；First piperazine card
Because of 1%；The ethanol extraction 3% of the dry polypide of periplaneta americana；Glycerol 3%, adds the weight fraction 75% of 9 times of functional component weight
Ethanol solution.The solution configured is loaded pressure inhalator jar.
Embodiment 11
Functional component configures 10% solution by following mass fraction: 1,1,1,3,3 ,-pentafluoropropane 90%；R-134a 2%；First piperazine card
Because of 1%；The ethanol extraction 3% of the dry polypide of periplaneta americana；Glycerol 4%, adds the weight fraction 75% of 9 times of functional component weight
Ethanol solution.The solution configured is loaded pressure inhalator jar.
Embodiment 12
The following mass fraction of functional component configures 5% solution: 1,1,1,3,3 ,-pentafluoropropane 94%；R-134a 1%；Mepivacaine
1%；Glycerol 4%, adds the ethanol solution of the weight fraction 75% of 19 times of functional component weight.The solution configured is loaded pressure
Power inhalator jar.
Comparative example 1
20% solution is configured: 1,1,1,3,3 ,-pentafluoropropane 82% by following mass fraction；R-134a 18%；Add 4 times 1,1,1,3,3 ,-
The ethanol solution of the weight fraction 75% of pentafluoropropane and R-134a weight, loads pressure inhalator jar by the solution configured.
Comparative example 2
10% solution is configured: 1,1,1,3,3 ,-pentafluoropropane 90% by following mass fraction；R-134a 10%；Add 9 times 1,1,1,3,3 ,-
The ethanol solution of the weight fraction 75% of pentafluoropropane and R-134a weight, loads pressure inhalator jar by the solution configured.
Comparative example 3
10% solution is configured: 1,1,1,3,3 ,-pentafluoropropane 95% by following mass fraction；R-134a 5%；Add 9 times 1,1,1,3,3 ,-
The ethanol solution of the weight fraction 75% of pentafluoropropane and R-134a weight, loads pressure inhalator jar by the solution configured.
Comparative example 4
5% solution is configured: 1,1,1,3,3 ,-pentafluoropropane 95% by following mass fraction；R-134a 5%；Add 19 times 1,1,1,3,3 ,-
The ethanol solution of the weight fraction 75% of pentafluoropropane and R-134a weight, loads pressure inhalator jar by the solution configured.
Comparative example 5
5% solution is configured: 1,1,1,3,3 ,-pentafluoropropane 99% by following mass fraction；Mepivacaine 1%；Add 19 times 1,1,1,3,3 ,-
The ethanol solution of the weight fraction 75% of pentafluoropropane and mepivacaine weight, loads pressure inhalator jar by the solution configured.
Comparative example 6
10% solution is configured: 1,1,1,3,3 ,-pentafluoropropane 95% by following mass fraction；Glycerol 5%；Add 9 times 1,1,1,3,3 ,-
The ethanol solution of the weight fraction 75% of pentafluoropropane and glycerin weight, loads pressure inhalator jar by the solution configured.
Comparative example 7
10% solution is configured: 1,1,1,3,3 ,-pentafluoropropane 96% by following mass fraction；The ethanol extraction of the dry polypide of periplaneta americana
4%；Add 9 times 1,1,1,3,3, the second of the weight fraction 75% of the ethanol extraction weight of-pentafluoropropane and the dry polypide of periplaneta americana
Alcoholic solution, loads pressure inhalator jar by the solution configured.
Result of the test is as follows:
Air cooling spray embodiment 1-12 and comparative example 1-7 prepared is used for clinical trial.
Find that the local skin anaesthetic effect of embodiment 1-12 is substantially better than comparative example 1-7, for pain during intramuscular injection,
Embodiment 1-12 is all without pain, and in comparative example 1-7, comparative example 1-3 has slight pain, and comparative example 4-7 has substantially pain.Muscle
Pin hole recovery effects after injection and the effect of reparation embodiment 7-11 of minor trauma are substantially better than other embodiments and right
Ratio, skin is recovered to have significantly effect by the ethanol extraction of this explanation dry polypide of periplaneta americana.
The above, the only present invention preferably detailed description of the invention, but protection scope of the present invention is not limited thereto, and any
Those of ordinary skill in the art in the technical scope that the invention discloses, the change that can readily occur in or replacement, all should contain
Within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with scope of the claims.
Claims (6)
1. a Novel air cold spray agent, it is characterised in that: functional component includes 1,1,1,3,3 ,-pentafluoropropane, R-134a and first piperazine
Caine, weight fraction ratio is as follows:
1,1,1,3,3 ,-pentafluoropropane 80-94%；
R-134a 0.1-20%；
Mepivacaine 0.2-3%.
2. Novel air cold spray agent as claimed in claim 1, it is characterised in that: the composition of each component and ratio of weight and number be:
1,1,1,3,3 ,-pentafluoropropane 82-94%；
R-134a 0.1-15%；
Mepivacaine 0.2-2%.
Novel air cold spray agent the most according to claim 1, it is characterised in that: described functional component also includes the dry worm of periplaneta americana
The ethanol extraction of body.
Novel air cold spray agent the most according to claim 1, it is characterised in that: the ethanol extraction of the dry polypide of described periplaneta americana
During extraction, the w/v of periplaneta americana and ethanol is 20:5-15, and it is 3-5% that extracting solution accounts for the weight fraction of functional component.
Novel air cold spray agent the most according to claim 1, it is characterised in that: functional component also including, weight fraction is 2-8%
Glycerol.
6. the using method of the Novel air cold spray agent described in an any one of claim 1-5, it is characterised in that: by functional component and
Pressure inhalator jar, low tempertaure storage or the 2-8 that sprays at skin 3-10cm is loaded after the ethanol solution mixing of weight fraction 75%
Second, then intravenous injection or bind up a wound at the spraying of skin, patient is without pain.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610398581.8A CN105902494A (en) | 2016-06-07 | 2016-06-07 | Novel air cooling spray and using method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610398581.8A CN105902494A (en) | 2016-06-07 | 2016-06-07 | Novel air cooling spray and using method thereof |
Publications (1)
| Publication Number | Publication Date |
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| CN105902494A true CN105902494A (en) | 2016-08-31 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610398581.8A Pending CN105902494A (en) | 2016-06-07 | 2016-06-07 | Novel air cooling spray and using method thereof |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6235265B1 (en) * | 1998-10-28 | 2001-05-22 | Alliedsignal Inc. | Evaporative coolant for topical anesthesia comprising hydrofluorocarbons and/or hydrochlorofluorocarbons |
| US6737041B1 (en) * | 1993-08-20 | 2004-05-18 | University Of Cincinnati | Non-ozone depleting vapocoolants |
| CN1778390A (en) * | 2004-11-18 | 2006-05-31 | 山东京卫制药有限公司 | Production of aerosol containing biological activity |
| CN1943600A (en) * | 2006-10-17 | 2007-04-11 | 耿福能 | Medicinal composition containing American cockroach and its ethanol extract and new use |
| CN103446052A (en) * | 2013-09-09 | 2013-12-18 | 马北峰 | Aerosol for treating micro-trauma of human body and using method thereof |
| CN103491778A (en) * | 2010-04-13 | 2014-01-01 | 雷尔玛达治疗股份有限公司 | Dermal pharmaceutical compositions of 1-methyl-2',6'-pipecoloxylidide and method of use |
-
2016
- 2016-06-07 CN CN201610398581.8A patent/CN105902494A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6737041B1 (en) * | 1993-08-20 | 2004-05-18 | University Of Cincinnati | Non-ozone depleting vapocoolants |
| US6235265B1 (en) * | 1998-10-28 | 2001-05-22 | Alliedsignal Inc. | Evaporative coolant for topical anesthesia comprising hydrofluorocarbons and/or hydrochlorofluorocarbons |
| CN1778390A (en) * | 2004-11-18 | 2006-05-31 | 山东京卫制药有限公司 | Production of aerosol containing biological activity |
| CN1943600A (en) * | 2006-10-17 | 2007-04-11 | 耿福能 | Medicinal composition containing American cockroach and its ethanol extract and new use |
| CN103491778A (en) * | 2010-04-13 | 2014-01-01 | 雷尔玛达治疗股份有限公司 | Dermal pharmaceutical compositions of 1-methyl-2',6'-pipecoloxylidide and method of use |
| CN103446052A (en) * | 2013-09-09 | 2013-12-18 | 马北峰 | Aerosol for treating micro-trauma of human body and using method thereof |
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Application publication date: 20160831 |