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CN105770974A - 一种医用痔疮生物敷料的制备方法 - Google Patents

一种医用痔疮生物敷料的制备方法 Download PDF

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CN105770974A
CN105770974A CN201610140643.5A CN201610140643A CN105770974A CN 105770974 A CN105770974 A CN 105770974A CN 201610140643 A CN201610140643 A CN 201610140643A CN 105770974 A CN105770974 A CN 105770974A
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preparation
biological dressing
alginate
parts
haemorrhoids
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李苏扬
李文遐
徐勤霞
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Suzhou Bec Biological Technology Co Ltd
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Suzhou Bec Biological Technology Co Ltd
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Abstract

本发明公开了一种医用痔疮生物敷料的制备方法，该制备方法先按重量份计，称取各原料置于反应器中搅拌均匀后，保持溶液温度为110℃，加热 10分钟后；将加热后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。通过本发明的方法制备的生物敷料采用中药配方，刺激性小，无毒副作用，不易复发，具有起效快、吸收完全，不伤黏膜，干净卫生的优点，疗效好，能够充分发挥药效作用，作用持续时间长，对外痔引起的出血、肿胀、疼痛、便秘等均有很好的疗效。

Description

一种医用痔疮生物敷料的制备方法
技术领域
本发明属于医用生物新材料领域，涉及一种医用痔疮生物敷料的制备方法。
技术背景
近年来，随着社会的发展，人们的压力越来越大，经常性的加班，导致坐的时间太长，再加上饮食结构和饮食习惯的改变，高热、辛辣、多油成为许多人的日常饮食口味，以及肥胖所引起的腹腔压力增大，使痔疮的发病率明显上升，在整个肛肠病中，痔疮的发病率约占87.3％。痔疮是由人体直肠末端黏膜下和肛管皮肤下静脉丛屈曲扩张形成的柔软静脉团。出血、搔痒、疼痛和脱出是痔疮的四种常见临床表现，同时痔疮也很容易引发肛肠疾病、贫血、妇科炎症、肛周湿疹、植物神经絮乱等其它系统性疾病。因此对痔疮进行及时的治疗，非常重要。
目前对痔疮的治疗方法有手术疗法、药物内服疗法和药物外用疗法，手术疗法给患者带来较大痛苦，在病后容易产生并发症，而药物内服疗法疗效慢，药物外用疗法使用的剂型多为洗剂，洗涤的时间通常较为短暂，药剂和黏膜接触的时间很少，同时药物不能存留，使得药物不能充分地发挥作用，而且疗效甚微，刺激性较大，甚至很多人为了快速治疗痔疮，采用注射治疗，然而注射治疗会带来一些副作用，且经常跑医院，造成诸多不便。
生物敷料是在Winter等提出的创伤修复“湿润愈合”理论基础上发展起来的新型创面修复及保护材料。与传统敷料相比，生物敷料具有降低感染、提高创面愈合质量、减轻病人的痛苦以及方便医护人员操作等优点，因此得到了人们的青睐。目前，我国市场具有自主知识产权的并用于痔疮修复的敷料还很少，几乎是空白。因此，研究新型的用于痔疮修复的敷料与制备方法，具有极其重要的意义。
发明内容
本发明的目的在于针对现有技术的不足，提供一种医用痔疮生物敷料的制备方法。
本发明的目的是通过以下技术方案实现的：一种医用痔疮生物敷料的制备方法，该制备方法包括以下步骤：按重量份计，称取纤维蛋白胶30-35份、壳聚糖30-35份、甲壳素5-10份、海藻酸盐4-12份、黄芪粉10-20份、桔梗粉10-20份、川芎粉14-20份、当归粉10-15份、枸杞粉11-17份、甘草酸二钾6-10份、透明质酸钠10-14份、乳化剂3-10份和水30-40份置于反应器中搅拌均匀后，保持溶液温度为110℃，加热10分钟后；将加热后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。
所述基布层为无纺布或PU防水透气膜。
所述粘结剂为压敏胶。
所述海藻酸盐为海藻酸钾、海藻酸钠或海藻酸钙。
所述乳化剂为硬脂酸单甘油脂或十二烷基硫酸钠。
本发明具有以下有益效果：通过本发明的方法制备的生物敷料采用中药配方，刺激性小，无毒副作用，不易复发，具有起效快、吸收完全，不伤黏膜，干净卫生的优点，疗效好，能够充分发挥药效作用，作用持续时间长，对外痔引起的出血、肿胀、疼痛、便秘等均有很好的疗效。
具体实施方式
实施例1
一种医用痔疮生物敷料的制备方法，该制备方法包括以下步骤：按重量份计，称取纤维蛋白胶33份、壳聚糖33份、甲壳素8份、海藻酸盐8份、黄芪粉15份、桔梗粉15份、川芎粉17份、当归粉13份、枸杞粉14份、甘草酸二钾8份、透明质酸钠12份、乳化剂6份和水35份置于反应器中搅拌均匀后，保持溶液温度为110℃，加热10分钟后；将加热后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。
所述基布层为无纺布或PU防水透气膜。
所述粘结剂为压敏胶。
所述海藻酸盐为海藻酸钾、海藻酸钠或海藻酸钙。
所述乳化剂为硬脂酸单甘油脂或十二烷基硫酸钠。
实施例2
一种医用痔疮生物敷料的制备方法，该制备方法包括以下步骤：按重量份计，称取纤维蛋白胶30份、壳聚糖30份、甲壳素5份、海藻酸盐4份、黄芪粉10份、桔梗粉10份、川芎粉14份、当归粉10份、枸杞粉11份、甘草酸二钾6份、透明质酸钠10份、乳化剂3份和水30份置于反应器中搅拌均匀后，保持溶液温度为110℃，加热10分钟后；将加热后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。
所述基布层为无纺布或PU防水透气膜。
所述粘结剂为压敏胶。
所述海藻酸盐为海藻酸钾、海藻酸钠或海藻酸钙。
所述乳化剂为硬脂酸单甘油脂或十二烷基硫酸钠。
实施例3
一种医用痔疮生物敷料的制备方法，该制备方法包括以下步骤：按重量份计，称取纤维蛋白胶35份、壳聚糖35份、甲壳素10份、海藻酸盐12份、黄芪粉20份、桔梗粉20份、川芎粉20份、当归粉15份、枸杞粉17份、甘草酸二钾10份、透明质酸钠14份、乳化剂10份和水40份置于反应器中搅拌均匀后，保持溶液温度为110℃，加热10分钟后；将加热后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。
所述基布层为无纺布或PU防水透气膜。
所述粘结剂为压敏胶。
所述海藻酸盐为海藻酸钾、海藻酸钠或海藻酸钙。
所述乳化剂为硬脂酸单甘油脂或十二烷基硫酸钠。

Claims (5)

1.一种医用痔疮生物敷料的制备方法，其特征在于该制备方法包括以下步骤：按重量份计，称取纤维蛋白胶30-35份、壳聚糖30-35份、甲壳素5-10份、海藻酸盐4-12份、黄芪粉10-20份、桔梗粉10-20份、川芎粉14-20份、当归粉10-15份、枸杞粉11-17份、甘草酸二钾6-10份、透明质酸钠10-14份、乳化剂3-10份和水30-40份置于反应器中搅拌均匀后，保持溶液温度为110℃，加热10分钟后；将加热后的混合物倒入制膜模具上，刮平，干燥充分后，脱膜，制得贮药层；最后将制备得到的贮药层和基布通过粘结剂粘接复合，利用密集针刺微孔机将粘结复合材料打孔；将打孔后的密集复合材料切割成所需形状，密封灭菌即可。
2.根据权利要求1所述一种医用痔疮生物敷料的制备方法，其特征在于：所述基布层为无纺布或PU防水透气膜。
3.根据权利要求1所述一种医用痔疮生物敷料的制备方法，其特征在于：所述粘结剂为压敏胶。
4.根据权利要求1所述一种医用痔疮生物敷料的制备方法，其特征在于：所述海藻酸盐为海藻酸钾、海藻酸钠或海藻酸钙。
5.根据权利要求1所述一种医用痔疮生物敷料的制备方法，其特征在于：所述乳化剂为硬脂酸单甘油脂或十二烷基硫酸钠。
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