CN105726661A - Compound preparation for eliminating toxins in livestock and poultry bodies and preparation method thereof - Google Patents
Compound preparation for eliminating toxins in livestock and poultry bodies and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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Abstract
The invention relates to a compound preparation for eliminating toxins in livestock and poultry bodies and a preparation method thereof. The compound preparation consists of the following raw materials in parts by weight: 5-15 parts of rhubarb, 10-20 parts of honeysuckle flower, 10-20 parts of dahurian patrinia herb, 10-20 parts of mung bean, 5-15 parts of licorice root, 10-30 parts of montmorillonite, 10-20 parts of sodium humate, 5-10 parts of vitamin C, and 5-10 parts of allicin. The compound preparation can eliminate the toxins in the livestock and poultry bodies, and has an irreplaceable advantage for the development of organisms of livestock and poultry. The compound preparation provided by the invention is used for correspondingly eliminating sources of the toxins in the livestock and poultry bodies, has a very strong effect of eliminating various toxins, and contains traditional Chinese medicines and mineral substances, so that the compound preparation is safe and effective, and does not have residues and drug tolerance.
Description
Technical field
The invention belongs to compound preparation field, be specifically related to a kind of compound preparation for removing livestock and poultry vivotoxin and
Preparation method.
Background technology
Endotoxin is the abnormal harmful substance in livestock and poultry body, can cause tissue inflammation, endotoxin in livestock and poultry body tissue
Entrance blood circulation may result in livestock and poultry and suffers from endotoxin disease, makes the reduction of organism fever, blood pressure, hepar damnification, nerve dysfunction, disappears
Change system or respiratory system occur abnormal, seriously can cause death.There is multiple endotoxin except harm animal body, also can remain
In animal body tissue, bring harm to Animal Food Security, eventually affect consumer health.
Vivotoxin is mainly derived from the following aspects:
1, livestock and poultry are under the stimulation of the strong factor such as get a fright, the especially adrenaline of the hormone in its blood and toxin
Hypersecretion, substantial amounts of hormone and toxin can be covered with toxic element along with sanguimotor urgent acceleration in body tissue.
2, bacterial endotoxin is the distinctive toxicity institutional framework on gram-negative bacteria cell wall, is mainly composed of fat many
Sugar.This is that bacterium produces during vital movement and discharges at any time or the toxicant of dead self-dissolving release.Such as killing property bar more
Family name bacillus, sepsis bordetella bacilli, pleurisy Actinobacillus, haemophilus, Escherichia coli etc..Or can induce when using antibiotic
Gram-negative bacteria discharges substantial amounts of bacteriotoxin.
3, moldy feed adds violated compound preparation in the mycotoxin of mould secretion, feed, as residual in medicine serious
Antibiotic, hormone etc.；Additionally containing exceeding standard or the toxic heavy metal element such as contaminated lead, cadmium, mercury, arsenic, these metals in feed
After element enters animal body, aoxidize through oxygen radical, a large amount of virose metal toxin can be produced, operate body.
4, livestock and poultry eat the feed and drinking-water by industrial wastewater pollution or containing pesticide sewage by mistake, can cause poisoning or produce in vivo
Raw hazard residue.Medication in violation of rules and regulations in treatment livestock and poultry, causes poisoning and medicament residue.It addition, in common livestock and poultry food
Poison, may result in noxious material and is deposited on internal etc..
Summary of the invention
It is an object of the invention to provide a kind of safe and effective, compound preparation for removing livestock and poultry vivotoxin of noresidue
And preparation method thereof.
For achieving the above object, the technical solution used in the present invention is, a kind of compound for removing livestock and poultry vivotoxin
Preparation, is made up of the raw material of following portions by weight: rheum officinale 5-15 part, honeysuckle 10-20 part, field pennycress 10-20 part, mung bean 10-
20 parts, Radix Glycyrrhizae 5-15 part, montmorillonite 10-30 part, sodium humate 10-20 part, vitamin C 5-10 part, allicin 5-10 part.
Preferably, the described compound preparation for removing livestock and poultry vivotoxin, it is made up of the raw material of following portions by weight: big
Huang 10 parts, honeysuckle 15 parts, field pennycress 10 parts, 10 parts of mung bean, 10 parts of Radix Glycyrrhizae, montmorillonite 20 part, sodium humate 10 parts, vitamin
C 10 parts, allicin 5 parts.
The preparation method of described compound preparation, comprises the following steps: take each raw material in proportion, by rheum officinale, honeysuckle, Patrinia scaniosaefolia
Grass, mung bean and Radix Glycyrrhizae carry out ultramicro grinding (being crushed to below 200 mesh) respectively and are placed in mixer, add montmorillonite, corruption
Sodium phytate, vitamin C and allicin, stir, and obtains described compound preparation.
The using method of invention formulation: mixed feeding, every 1000g spice 300 ~ 400kg, it is used in conjunction 7-15 days.
Rheum officinale, belongs to purgatives medicine.The nucleic acid of bacterium and the synthesis of protein are had and significantly press down by the anthraquinone derivative in rheum officinale
Make use, effectively kill the blue many negative bacterium of leather, the verticillium toxin of suppression Gram-negative bacteria secretion.The tan glycoside material of rheum officinale is to stomach
Intestinal mucosa has astriction, absorbs harmful substance in intestines and stomach, and Rhein stimulates big intestinal wall, promotes that intestinal peristalsis and secretion increase
Adding, so a large amount of intestinal juice can dilute the virulence of verticillium toxin, and borrows enterocinesia to be excreted by the nuisances such as toxin.
Honeysuckle, containing antibacterial substances such as honeysuckle flower alkali, bios Ⅰ, lonicerin, tannic acids, honeysuckle is broad spectrum antibiotic
Thing, has significantly suppression and deactivation to the various bacteria such as Gram-positive, feminine gender and influenza virus.Its contained multiple life
The materials such as alkaloids, alcohol, glycosides, tannic acid have antagonism to the bacterium of germ secretion or self-dissolving, remove poison or toxicity reduction effect, contained by honeysuckle
Tannin gastrointestinal mucosa is had astriction, resist the stomach and intestine absorption to harmful substance, it is ensured that gastrointestinal function health plays and machine
Body is healthy.
Field pennycress, belongs to clearing heat and promoting diuresis, removing toxic substances apocenosis, a stasis of blood class medicine of invigorating blood circulation.It is containing abundant volatile oil, multiple saponin, tan
Matter and multiple alkaloid.Multiple germ is killed and antivirus action.Research shows, the tannin in field pennycress can restrain stomach and intestine
Mucous membrane, stops or suppresses gastrointestinal mucosa to the absorption of harmful substance in alimentary canal；Alkaloid, glucoside and volatile oil in field pennycress
Verticillium toxin secreted by the bacterium such as Escherichia coli, shigella dysenteriae is produced antagonism, makes verticillium toxin virulence remove or reduce, can
Effectively prevent endotoxin from body being endangered.
Mung bean, mung bean protein, tannin and flavone compound can be harmful with organophosphorus pesticide, verticillium toxin, mercury, arsenic, lead etc.
The compounds such as heavy metal ion combine to be formed and promote the sediment of toxicity or minimizing toxicity, the absorption of stomach and intestine difficulty to discharge body with ight soil
Outward.Mung bean protein matter and antioxidation biology can protect gastrointestinal mucosa from harmful substance pessimal stimulation simultaneously, reduce endotoxic
The extent of injury.
Radix Glycyrrhizae, glycyrrhizin have strong detoxication, as in verticillium toxin, snake venom, pesticide poisoning, interior metabolism product
Drug poisoning, anaphylactia, the tetanus toxins such as poison, food poisoning have good detoxication.Mechanism of action is: glycyrrhizin
Element, Radix Glycyrrhizae class cortex hormone of aadrenaline have neutralization and adsorpting detoxication effect to all poison.It is reported, Radix Glycyrrhizae decocts juice can significantly reduce ox
The harmful heavy metal ions content of residual in soma.
Montmorillonite, is the silicate clay ore deposit without harmful heavy metal purified from bentonite.Alternative antibiotic therapy
Diarrhoea.Protected gastrointestinal mucosa, extremely strong absorption Escherichia coli, comma bacillus, campylobacter jejuni and wheel in animal gastrointestinal tract
Pathogenic microorganism and the verticillium toxin of generation, the effects of enterotoxin such as shape virus, and excrete nuisance, reach sterilization,
The effect such as antidiarrheal, removing toxic substances.Another reported, daily ration adds 0.5% montmorillonite and can significantly improve the damage of lead induction and the residual of lead
Allowance.
Sodium humate, is the multi-functional organic monoacid salt extracted from coal class.Active decomposable asymmetric choice net in sodium humate goes out nascent
State oxygen, has the effects such as sterilization, block, pain relieving, anti-inflammatory；There are stronger absorption affinity and complexing power simultaneously, stomach intestinal toxic can be adsorbed
Material and bacteriotoxin, harmful heavy metal ions etc., present good health care.
Gut barrier function caused by vitamin C induced by endotoxin destroys obvious therapeutic action, can substantially reduce enteron aisle
Bacterium migrates incidence and the bacterium amount of migrating, and the curative effect that intestinal mucosal barrier is destroyed by data display vitamin C is substantially better than endogenous toxic material
Intestinal mucosal barrier caused by element destroys, and is administered orally and compares with two kinds of routes of administration of intravenously administrable, and oral route is better than quiet
Arteries and veins approach.
Allicin, is three thio-allyl ether compounds, is naturally occurring in the bulb of liliaceous plant garlic.To multiple
Gram-positive and negative bacterium all have antibacterial action, to bacillus (shigella dysenteriae, typhoid bacillus, Escherichia coli, Bordetella pertussis),
Fungi (Candida albicans, cryptococcus, aspergillus fumigatus), virus (cytomegalovirus), Amoeba, Trichomonas vaginalis, pinworm etc.
All there is suppression killing action, especially strong to the enteric bacteria effect such as Escherichia coli, shigella dysenteriae.Have strong disinfecting, removing toxic substances is protected
Strong, improve the effect such as immunity, mould-proof disinsectization, and can effectively suppress and kill the bacterium such as helicobacter pylori causing gastrointestinal disease
Virus, removes stomach noxious material, stimulating gastrointestinal mucous membrane, promotes appetite.
The beneficial effect comprise that: (1) present invention can effectively remove the various toxin in livestock and poultry body, strengthens disease-resistant
Ability；(2) inventive mixture abundant raw material source, and production technology is easy；(3) inventive mixture is ultra-micro powder,
Fineness, up to 200 mesh, is readily absorbed by after entering body, and clinical administration is convenient, is suitable for colony and is administered, uses manpower and material resources sparingly；
(3) medicament contg of the present invention is clear and definite, is administered accurately, quality controllable.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, but protection scope of the present invention is not limited to this.
Embodiment 1
A kind of compound preparation for removing livestock and poultry vivotoxin, is made up of the raw material of following portions by weight: rheum officinale 5 parts, gold and silver
Spend 10 parts, field pennycress 10 parts, 15 parts of mung bean, 15 parts of Radix Glycyrrhizae, montmorillonite 30 parts, sodium humate 20 parts, vitamin C 5 parts, garlic
Element 10 parts.
The preparation method of the described compound preparation for removing livestock and poultry vivotoxin, comprises the following steps: take each in proportion
Raw material, carries out rheum officinale, honeysuckle, field pennycress, mung bean and Radix Glycyrrhizae ultramicro grinding (being crushed to below 200 mesh) respectively and is placed on mixed
In conjunction machine, add montmorillonite, sodium humate, vitamin C and allicin, stir, obtain described compound preparation.
Embodiment 2
A kind of compound preparation for removing livestock and poultry vivotoxin, is made up of the raw material of following portions by weight: rheum officinale 10 parts, gold and silver
Spend 15 parts, field pennycress 10 parts, 10 parts of mung bean, 10 parts of Radix Glycyrrhizae, montmorillonite 20 part, sodium humate 10 parts, vitamin C 10 parts, garlic
Element 5 parts.
The preparation method of the compound preparation for removing livestock and poultry vivotoxin of the present embodiment is same as in Example 1.
Embodiment 3
A kind of compound preparation for removing livestock and poultry vivotoxin, is made up of the raw material of following portions by weight: rheum officinale 10 parts, gold and silver
Spend 20 parts, field pennycress 20 parts, 20 parts of mung bean, 5 parts of Radix Glycyrrhizae, montmorillonite 10 parts, sodium humate 10 parts, vitamin C 5 parts, allicin
5 parts.
The preparation method of the compound preparation for removing livestock and poultry vivotoxin of the present embodiment is same as in Example 1.
Application test
On pig liver disease and the impact of enzyme activity of liver:
Select the tune giving treatment to the sow 120 in pig farm, Zhongmou County during the 2014.12-2015.8 month as this time research topic
Check as.Sick pig fleece slightly disorderly, all has gum, the symptom of tear spot.According to measurement, the body weight of 120 sick pigs of this group 180～
Between 210kg, the average weight of sick pig is (190 ± 9.2) kg.120 pigs using random manner this to be organized are average
It is divided into observation group 1,2,3 and control group, 4 groups of disease pig numbers to be 30.
Control group uses the mode for the treatment of by Chinese herbs to treat 30 sick pigs of control group, all gives Longdanxiegan and dissipates
(Zhengzhou Mu Gang animal pharmaceutical estate Co., Ltd) treats.Concrete usage and dosage is: every 1000g spice 400kg, continuous use
15d。
Observation group 1-3 is respectively adopted the Chinese medicine preparation of the embodiment of the present invention 1,2,3 30 sick pigs respectively to each observation group
Treating, concrete usage and dosage is: mixed feeding, every 1000g spice 400kg, is used in conjunction 15d.
The treatment results of observation group 1-3 and control group is shown in Table 1
Table 1 observation group 1-3 and the treatment results of control group
Note: effective is pig gum, the disappearance of tear spot, fur light；Being effectively pig gum, the disappearance of tear spot, fur improves；Invalid is pig
Gum, tear spot do not disappear, and fleece is slightly disorderly.
As can be seen from Table 1,4 groups of disease pigs are after accepting treatment, and clinical symptoms and sign are all improved and control, and observe
The total effective rate of the treatment of the sick pig of group is 98.9%, and the total effective rate of the treatment of control group disease pig is 73.3%, the difference between two groups
Different significantly.Vivotoxin exceedes the liver detoxification upper limit, and toxin is just discharged from eyes, and gum, tear spot are exactly product, and toxin amasss in a large number
Store in internal, compromised liver function, necessarily cause swine disease to become, illustrate that the removing of vivotoxin is had bright by the compound preparation of the present invention
Aobvious effect.
Separately detect pig liver enzymatic activity index in off-test, as shown in table 2:
The pig liver enzymatic activity index of table 2 observation group 1-3 and control group
。
As can be seen from Table 2, three test group liver glutamic-pyruvic transaminase (glutamic-pyruvic transaminase), glutamic-oxalacetic transaminease (GOT), alkali
Acid phosphatase (ALP) and glutathione S-transferase (GST) activity are all significantly improved than control group, and answering of the present invention is described
Animal's liver can be played the effect of protection by square preparation.
Claims (3)
1. the compound preparation being used for removing livestock and poultry vivotoxin, it is characterised in that be made up of the raw material of following portions by weight:
Rheum officinale 5-15 part, honeysuckle 10-20 part, field pennycress 10-20 part, mung bean 10-20 part, Radix Glycyrrhizae 5-15 part, montmorillonite 10-30 part,
Sodium humate 10-20 part, vitamin C 5-10 part, allicin 5-10 part.
2. as claimed in claim 1 for removing the compound preparation of livestock and poultry vivotoxin, it is characterised in that by following portions by weight
Raw material composition: rheum officinale 10 parts, honeysuckle 15 parts, field pennycress 10 parts, 10 parts of mung bean, 10 parts of Radix Glycyrrhizae, montmorillonite 20 part, corruption are planted
Acid 10 parts of sodium, vitamin C 10 parts, allicin 5 parts.
3. the preparation method of compound preparation as described in claim 1 or 2, it is characterised in that comprise the following steps: take in proportion
Each raw material, carries out rheum officinale, honeysuckle, field pennycress, mung bean and Radix Glycyrrhizae ultramicro grinding respectively and is placed in mixer, add illiteracy
De-stone, sodium humate, vitamin C and allicin, stir, obtain described compound preparation.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610185158.XA CN105726661A (en) | 2016-03-29 | 2016-03-29 | Compound preparation for eliminating toxins in livestock and poultry bodies and preparation method thereof |
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| CN201610185158.XA CN105726661A (en) | 2016-03-29 | 2016-03-29 | Compound preparation for eliminating toxins in livestock and poultry bodies and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106421175A (en) * | 2016-11-30 | 2017-02-22 | 郑州马基森生物科技有限公司 | Compound traditional Chinese medicine preparation for eliminating endotoxin of livestock and poultry and preparation method thereof |
| CN109316533A (en) * | 2018-12-05 | 2019-02-12 | 长沙绿叶生物科技有限公司 | It is a kind of remove pig vivotoxin fermented tcm compound preparation and its application |
| CN109452489A (en) * | 2018-11-14 | 2019-03-12 | 东北农业大学 | The feed addictive of fluoride protector, feed and its preparation method and application in a kind of elimination poultry body |
| CN113198007A (en) * | 2021-04-15 | 2021-08-03 | 河南省帮邦生物工程有限公司 | Compound preparation for clearing pig endotoxin and preparation method thereof |
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| CN103405581A (en) * | 2013-07-24 | 2013-11-27 | 天津集合科技有限公司 | Compound grape seed powder for clearing toxin inside livestock and protecting digestive system |
| CN104147467A (en) * | 2014-06-26 | 2014-11-19 | 潍坊诺达药业有限公司 | Traditional Chinese medicine for treating endotoxemia of poultry and livestock and preparation process thereof |
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| CN103405581A (en) * | 2013-07-24 | 2013-11-27 | 天津集合科技有限公司 | Compound grape seed powder for clearing toxin inside livestock and protecting digestive system |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106421175A (en) * | 2016-11-30 | 2017-02-22 | 郑州马基森生物科技有限公司 | Compound traditional Chinese medicine preparation for eliminating endotoxin of livestock and poultry and preparation method thereof |
| CN109452489A (en) * | 2018-11-14 | 2019-03-12 | 东北农业大学 | The feed addictive of fluoride protector, feed and its preparation method and application in a kind of elimination poultry body |
| CN109316533A (en) * | 2018-12-05 | 2019-02-12 | 长沙绿叶生物科技有限公司 | It is a kind of remove pig vivotoxin fermented tcm compound preparation and its application |
| CN109316533B (en) * | 2018-12-05 | 2021-06-15 | 长沙绿叶生物科技有限公司 | Fermented traditional Chinese medicine compound preparation for removing endotoxin in pig body and application thereof |
| CN113198007A (en) * | 2021-04-15 | 2021-08-03 | 河南省帮邦生物工程有限公司 | Compound preparation for clearing pig endotoxin and preparation method thereof |
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