CN105707890A - Soft capsule suitable for females in pregnancy-preparation stage to take - Google Patents

Abstract

The invention discloses a soft capsule suitable for females in the pregnancy-preparation stage to take. The soft capsule is prepared from, by weight, 0.9-5 parts of seaweed extracts, 1.3-5 parts of resveratrol, 60-80 parts of vitamin C, 30-40 parts of vitamin E, 1-2 parts of vitamin B1, 1-2 parts of vitamin B2, 1-2 parts of vitamin B6, 0.0015-0.0025 part of vitamin B12, 0.325-0.4 part of folic acid, 10-50 parts of beta-carotene, 9-20 parts of sodium selenite, 20-75 parts of zinc sulfate, 55-80 parts of ferrous fumarate, 400-650 parts of soybean oil, 20-40 parts of soyabean lecithin, 20-40 parts of beewax, 5-25 parts of citrus bioflavonoids, 10-30 parts of arginine and 15-30 parts of inositol. The capsule suitable for females in the pregnancy-preparation stage and used for supplementing natural active substances and nutrients is developed, the capsule contains vitamin, mineral substances and natural active substances needed for females in the pregnancy-preparation stage, the natural active substances are specially added and have the effects of resisting oxidization, removing free radicals and conditioning acid base equilibrium in vivo, the organic combination of vitamin, mineral substances and natural active substances can comprehensively provide nutrient for females in the pregnancy-preparation stage, and preparation is made for giving birth to a healthy baby.

Description

A kind of it is applicable to the soft capsule that woman preparing for pregnancy is taken

Technical field

The present invention relates to nutritious health caring food technology field, a kind of be applicable to the flexible glue that woman preparing for pregnancy is taken Capsule.

Background technology

During Pregnancy is an extremely complex process, and along with society development to the mankind bring huge material and Spiritual wealth, but the composite factor such as environmental pollution, social pressure also have impact on the fertility of women.According to another estimation, the whole world is every There are about more than 500 ten thousand Fetal malformation births year.China is birth defect country occurred frequently, and the Prevalence rate of birth defect of current China exists About 5.6%, annual newly-increased birth defect about 900,000 example.Birth defect is to cause Threatened abortion, stillborn fetus, perinatal infants dead rate, baby The dead main cause with developmental disability of child.

Female fertility is the key factor affecting birth defect, and the factor affecting female fertility ability is substantially divided For environmental factors, physiologic factor, pathological factor, social factor and other factors.

Environmental factors refers to that every day is all exposed in varying environment chaff interference by different approaches, is correlated with including life style Risk factor, occupation Related Risk Factors and endocrine factors.Having research display, being exposed to pesticide in agricultural occupation can notable shadow Ring female reproductive system, reduce fertility；The organic solvents such as styrene, mercury metal and lead contamination all can directly or indirectly damage female Sexual reproduction is healthy.Endocrine factors refers to ectogenic chemical substance and mixture disturbance endocrine systemic-function.Gonadal hormone and The disease that the disorder of the endocrinal environment such as thyroid may cause have ovarian dysfunction, hysteropathy, disorder of placental function and Averse pregnancy outcomes, mastopathy.

Physiologic factor is the major physiological factor affecting female fertility.Increasing with the age, infertility incidence rate increases Adding, fertility reduces, and shows as pregnancy rate and reduces, and abortion ratio increases, and the Mean Time Between Replacement of fertility extends, and breeds filial generation dye Colour solid exception probability increases, and live birth rate reduces.The main cause that female age increase causes fertility to decline is ovarian reserve merit Can reduce, main cause is that the Follicle number raised retained in ovary reduces and ovum quality declines.Premature ovarian failure (POF) is The common pathological factor having a strong impact on female fertility.

Other factor bad life style and excessive mental pressure all can produce impact to fertility.Bad life style bag Include: smoking, drink, long-term taking caffeine, irregular diet, malnutrition or overnutrition.Lipid oxidation in smoker's follicle Product increases, and antioxygen power weakens, and oxidative stress causes apoptosis and the chromosome heteroploid of cell, may cause increasing and miscarry, early Produce or ectopic pregnancy, FGR, the probability of fetal development deformity.

Be main for the nutrient prime replenisher preparing conceived women product the most single in the market, different brands it Between main based on the difference on vitamin, mineral formulations and content, not for prepare fertility women the actual meals faced Food structure, physiology, environmental quality product targetedly.

Summary of the invention

It is an object of the invention to provide and a kind of be applicable to the soft capsule that woman preparing for pregnancy is taken, to solve above-mentioned background skill The problem proposed in art.

For achieving the above object, the present invention provides following technical scheme:

A kind of it is applicable to the soft capsule that woman preparing for pregnancy is taken, is made up of according to weight portion following material: Sargassum extract 0.9-5 Part, resveratrol 1.3-5 part, vitamin C 60-80 part, vitamin E 30-40 part, vitamin B₁1-2 part, vitamin B₂ 1-2 Part, vitamin B₆1-2 part, vitamin B₁₂0.0015-0.0025 part, folic acid 0.325-0.4 part, beta-carotene 10-50 part, Sodium selenite 9-20 part, zinc sulfate 20-75 part, ferrous fumarate 55-80 part, soybean oil 400-650 part, soybean phospholipid 20-40 Part, Cera Flava 20-40 part, citrus flavonoids 5-25 part, arginine 10-30 part, inositol 15-30 part.

As the further scheme of the present invention: be made up of according to weight portion following material: Sargassum extract 1.9-4 part, white Veratryl alcohol 2.3-4 part, vitamin C 65-75 part, vitamin E 33-37 part, vitamin B₁1.3-1.7 part, vitamin B₂ 1.3- 1.7 parts, vitamin B₆1.3-1.7 part, vitamin B₁₂0.0018-0.0022 part, folic acid 0.35-0.375 part, beta-carotene 30-40 part, sodium selenite 12-17 part, zinc sulfate 35-60 part, ferrous fumarate 65-70 part, soybean oil 450-600 part, Semen sojae atricolor Phosphatidase 2 5-35 part, Cera Flava 25-35 part, citrus flavonoids 10-20 part, arginine 15-25 part, inositol 18-27 part.

According to the preparation method being applicable to the soft capsule that woman preparing for pregnancy is taken described in any of the above technical scheme, its bag Include following steps:

(1) preparation of Sargassum extract: take a certain amount of Sargassum, adds a certain amount of cellulase, is dissolved in water, and regulates ph= 5.3, after constant temperature enzyme a period of time at a certain temperature, it is warming up to 100 DEG C of heating 5min and makes enzyme inactivate, cold filtration, concentrate, add Entering dehydrated alcohol to determining alcohol is 80%, stands, centrifugal, obtains Sargassum extract；

(2) preparation of citrus flavonoids: the ethanol water of size-reduced Citrus powder and 75% is put for 1:1-5 by weight In extractor, extract 0.5-1 hour at reflux, repeat 2-3 time, merging filtrate, concentrated, dry, obtain Citrus Flavonoid extract；

(3) dispensing: by prescription requirements, by Cera Flava by a certain amount of soybean oil heating for dissolving, controls temperature at 70-75 DEG C, after dissolving Adding soybean phospholipid mix and blend 15min, rotating speed is 35rpm, then by Sargassum extract, resveratrol, inositol, arginine, Vitamin E, vitamin C, vitamin B₁, vitamin B₂, vitamin B₆, vitamin B₁₂, folic acid, beta-carotene, vitamin E, richness Horse acid ferrous iron, sodium selenite, zinc sulfate add stir about 30min in mixed material, rotating speed 35rpm, evacuation (vacuum after stirring Degree-0.08Mpa, time 15-30min), keep about 30-40 DEG C, sieve 80 mesh；

(4) colloidal sol: put into recipe quantity purified water, glycerol in changing glue tank, stir to being completely dissolved under the conditions of 65 DEG C, then input is joined Side's amount gelatin and pigment, be warming up to 75-80 DEG C, and (vacuum is-0.08MPa, the time for stirring and dissolving 60-80 minute, evacuation 30-40 minute) to glue bubble-free, then glue is crossed 120 mesh sieves and releases glue, stand more than 4 hours, keep glue 45- About 60 DEG C, stand-by；

(5) pelleting: check capsule 's content to be pressed and the glue name of an article, specification, lot number etc., carry out pelleting with soft capsule filling machine, Regulation rubber thickness (0.70-0.80mm), controls content content uniformity.

Compared with prior art, the present invention have developed a kind of natural active matter being suitable for standby pregnant women and nutrient supplements Capsule, containing vitamin, mineral needed for promising woman preparing for pregnancy and be especially added with have antioxidation, remove free radical, tune Managing the natural active matter of internal acid-base balance, their organic assembling can supplement the nutrients all sidedly for standby pregnant women, makes a living Educate healthy baby to prepare.

Detailed description of the invention

Below in conjunction with detailed description of the invention, the technical scheme of this patent is described in more detail.

Embodiment 1

A kind of it is applicable to the soft capsule that woman preparing for pregnancy is taken, is made up of according to weight portion following material: Sargassum extract 0.925 Part, resveratrol 1.387 parts, vitamin C 68 parts, vitamin E 30 parts, vitamin B₁1 part, vitamin B₂1.2 parts, dimension life Element B₆1.2 parts, vitamin B₁₂0.0015 part, 0.375 part of folic acid, beta-carotene (30%) 12 part, sodium selenite (0.5%) 9.26 parts, 29.75 parts of zinc sulfate (water), ferrous fumarate 56.14 parts, soybean oil 629 parts, soybean phospholipid 20 parts, Cera Flava 30 Part, arginine 12.03 parts, inositol 22.31 parts.

Embodiment 2

A kind of it is applicable to the soft capsule that woman preparing for pregnancy is taken, is made up of according to weight portion following material: Sargassum extract 2.357 Part, resveratrol 3.754 parts, vitamin C 80 parts, vitamin E 40 parts, vitamin B₁1.5 parts, vitamin B₂1.5 parts, dimension Raw element B₆1.5 parts, vitamin B₁₂0.002 part, 0.35 part of folic acid, beta-carotene (30%) 30 part, sodium selenite (0.5%) 12 Part, 40 parts of zinc sulfate (water), ferrous fumarate 60 parts, citrus flavonoids 5 parts, soybean oil 562 parts, soybean phospholipid 30 parts, honeybee 20 parts of wax, arginase 12 0 part, inositol 15 parts.

Embodiment 3

A kind of it is applicable to the soft capsule that woman preparing for pregnancy is taken, is made up of according to weight portion following material: Sargassum extract 3.5 Part, resveratrol 4.5 parts, vitamin C 100 parts, vitamin E 45 parts, vitamin B₁1.8 parts, vitamin B₂1.8 parts, dimension life Element B₆1.8 parts, vitamin B₁₂0.003 part, 0.4 part of folic acid, beta-carotene (30%) 40 part, sodium selenite (0.5%) 15 part, 60 parts of zinc sulfate (water), ferrous fumarate 70 parts, soybean oil 474 parts, soybean phospholipid 35 parts, 25 parts of Cera Flava, citrus flavonoids 2 Part, arginase 12 5 parts, inositol 20 parts.

Embodiment 4

A kind of it is applicable to the soft capsule that woman preparing for pregnancy is taken, is made up of according to weight portion following material: Sargassum extract 4.0 Part, resveratrol 5.0 parts, vitamin C 80 parts, vitamin E 40 parts, vitamin B₁2 parts, vitamin B₂2 parts, vitamin B₆ 2 parts, vitamin B₁₂0.0024 part, 0.4 part of folic acid, beta-carotene (30%) 50 part, sodium selenite (0.5%) 18 part, zinc sulfate (water) 75 parts, ferrous fumarate 80 parts, soybean oil 452 parts, soybean phospholipid 40 parts, 30 parts of Cera Flava, arginine 15 parts, inositol 30 Part.

The preparation method being applicable to the soft capsule that woman preparing for pregnancy is taken for above example comprises the following steps:

(1) preparation of Sargassum extract: take a certain amount of Sargassum, adds a certain amount of cellulase, is dissolved in water, and regulates ph= 5.3, after constant temperature enzyme a period of time at a certain temperature, it is warming up to 100 DEG C of heating 5min and makes enzyme inactivate, cold filtration, concentrate, add Entering dehydrated alcohol to determining alcohol is 80%, stands, centrifugal, obtains Sargassum extract；

(2) preparation of citrus flavonoids: the ethanol water of size-reduced Citrus powder and 75% is put for 1:1-5 by weight In extractor, extract 0.5-1 hour at reflux, repeat 2-3 time, merging filtrate, concentrated, dry, obtain Citrus Flavonoid extract；

(3) dispensing: by prescription requirements, by Cera Flava by a certain amount of soybean oil heating for dissolving, controls temperature at 70-75 DEG C, after dissolving Adding soybean phospholipid mix and blend 15min, rotating speed is 35rpm, then by Sargassum extract, resveratrol, inositol, arginine, Vitamin E, vitamin C, vitamin B₁, vitamin B₂, vitamin B₆, vitamin B₁₂, folic acid, beta-carotene, vitamin E, richness Horse acid ferrous iron, sodium selenite, zinc sulfate add stir about 30min in mixed material, rotating speed 35rpm, evacuation (vacuum after stirring Degree-0.08Mpa, time 15-30min), keep about 30-40 DEG C, sieve 80 mesh；

(4) colloidal sol: put into recipe quantity purified water, glycerol in changing glue tank, stir to being completely dissolved under the conditions of 65 DEG C, then put into Formula ratio gelatin and pigment, be warming up to 75-80 DEG C, and (vacuum is-0.08MPa, the time for stirring and dissolving 60-80 minute, evacuation 30-40 minute) to glue bubble-free, then glue is crossed 120 mesh sieves and releases glue, stand more than 4 hours, keep glue 45- About 60 DEG C, stand-by；

(5) pelleting: check capsule 's content to be pressed and the glue name of an article, specification, lot number etc., carry out pelleting with soft capsule filling machine, Regulation rubber thickness (0.70-0.80mm), controls content content uniformity.

Have a try effect experimental:

The soft capsule taken to be applicable to woman preparing for pregnancy in embodiment 4 implements antioxidation experiment, the adult (60kg) of the present invention Meter recommended intake 0.925g/d, i.e. 0.015g/Kg.bw, animal uses Kunming mouse and presses as experimental system, experiment Human intaking amount 5 times, 10 times, 20 times set 0.075 respectively, 0.15, tri-dosage groups of 0.3g/Kg.bw, be equivalent to every kilopond little Mus injection Sargassum extract is respectively 0.32mg, 0.64mg and 1.28mg；Resveratrol be respectively 0.41mg, 0.82mg and 1.74mg；Vitamin C is respectively 6.4mg, 12.8mg and 25.6mg；Beta-carotene is respectively 4.1mg, 8.2mg and 17.4mg. After gavage 30d, 12h on pretreatment, to prohibit water, fasting, weigh body weight, carry out last gavage in advance half an hour, animal eyeball is extractd Blood sampling, tests, respectively in detection mice serum according to the method for regulation in " health food inspection and assessment technique specification " Superoxide dismutase (SOD) vigor, the vigor of glutathion peroxidase (GSH-Px) and lipid peroxide degraded are produced Thing trace malonaldehyde (MDA) content.

1, Mouse Weight result of variations:

Drawn by the first body weight of experiment mice each to anti-oxidation function and end body weight determination result, mice between each experimental group Original body mass no significant difference (P 0.05), the dosage group experiment opisthosoma weight of each product compares all without statistics with blank group Learn meaning (P 0.05).

2, the analysis of experimental data of each index of antioxidation:

Antioxidant Indexes comparative result in table 1 Mice Body:

Note:^*Represent and compare statistically significant with blank group, P ＜ 0.05

^**Represent and compare that there were significant differences with blank group, P ＜ 0.01

(1) to have the one-component such as Sargassum extract and resveratrol higher for the soft capsule that the woman preparing for pregnancy of the present invention is taken Improve the effect of SOD vigor.

Table 1 result shows, for the SOD effect of vigor in mice serum, although in each one-component all with blank group ratio Relatively increasing, but do not have statistical significance, the soft capsule that the woman preparing for pregnancy of the present invention is taken then has statistics meaning Justice.Middle dosage group, each composition can improve SOD vigor, all have statistical significance, the present invention then significant difference；Only exist In high dose group, all of one-component just improve SOD the vigor the same with present invention compares with blank group and has significant difference.

Therefore, the present invention is improving SOD vigor effect than simple Sargassum extract, resveratrol, beta-carotene, dimension Raw element C is much better than.

(2) soft capsule that the woman preparing for pregnancy of the present invention is taken has Sargassum and adds the one-component such as extract and resveratrol The effect of higher raising GSH-Px vigor.

Table 1 result shows, low dose group, and the present invention can significantly improve GSH-Px vigor, has a significant difference, and each list One component all not statistically significants.Middle dosage group, the present invention can significantly improve GSH-Px vigor, has significant difference, and dimension is raw Element C can not significantly improve GSH-Px vigor, not statistically significant；Simple Sargassum extract, resveratrol, beta-carotene tool There is significant difference.In high dose group, each composition is respectively provided with statistical significance, but the present invention has significant difference, therefore, The present invention has higher raising GSH-Px vigor effect than one-component.Sargassum extract, resveratrol, β-Radix Dauci Sativae are described Element and vitamin C synergy can be obviously enhanced GSH-Px vigor in mice serum, more much better than than each component independent role.

(3) present invention has the suppression MDA generation effect more higher than the one-component such as Sargassum extract, resveratrol.

From each experimental group on mice serum MDA content to affect result as shown in table 1.As can be seen from the table: blank group MDA content is the highest, reaches 12.14 ± 0.91 (MDA/mmol/mL)；And the present invention is minimum, only 5.23 ± 0.76 (MDA/mmd/ mL).Each one-component a little higher than present invention of dosage group is applicable to the soft capsule that woman preparing for pregnancy is taken.Significance level is tested Result shows: compare between each oligomict low dose group with blank group, the impact of MDA content in mice serum is not had system Meaning (P 0.05) learned by meter；Middle dosage group, Sargassum extract and vitamin C not statistically significant；High dose group, vitamin C are not There is statistical significance, and dosage group significant difference (P < 0.01) compared with blank group of the only present invention, illustrate the present invention MDA content in mice serum is significantly reduced effect.From above experimental result it can be seen that eaten the suitable of the present invention MDA content in the mice serum of the soft capsule taken for woman preparing for pregnancy is significantly lower than blank group, and SOD and GSH-Px lives Power will be apparently higher than naive mice.

In sum, the present invention is formed by compatibilities such as Sargassum extract, resveratrol, beta-carotene, vitamin Cs, from Upper analysis of experimental data illustrates, compares the one-components such as Sargassum extract, resveratrol, beta-carotene, vitamin C, the present invention More comprehensively, function is more perfect for effect, can significantly improve SOD, GSH-Px vigor of mice serum and reduce internal MDA content.This Invention has obvious antioxidation, it is possible to free radical too much in purged body, and this anti-oxidation function is better than each One-component, has positive effect to improving women for pregnancy period probability of becoming pregnant.

The present invention is a kind of nutraceutical novel, comprehensive, and containing potent anti-oxidation active substance in invention, opposing is outside Environmental factors and the oxidation of body own cells, enhancing immunity and oxidation resistance, improve women comprehensively and become pregnant the soft of probability Capsule.The Sargassum extract that used, resveratrol, beta-carotene have potent antioxidation, promote the work of follicle vigor Sex factor and the opposing external environment condition oxidative damage to body, the enzyme activity making cells in vivo and protein is higher, enhancing body Immunocompetence, simultaneously add prevention birth defect needed for each biostearin and mineral be improved female body function, in advance Anti-anemia, antioxidation, is element necessary to human body.The compounded combination of formula for a product, reaches synergism, comprehensively, all Weighing apparatus ground is the pregnant front extra-nutrition of women, makes product effect the most prominent.

Sargassum extract: marine algae, rich in Sargassum polysaccharides, mannitol, vitamin, belongs to base-forming food low in calories, often eats Contribute to improving the acidic physique of women, regulate and cause acid easy fat body because taking in too much meat and fat content foods Matter；Containing more rhamnose in Sargassum polysaccharides, gelation protecting film can be formed under acid condition under one's belt, stomach wound surface is had Cover, protect, prevent mucosal inflammation effect, and also alimentary canal inflammation can be changed, such as Nausea and vomiting, pain etc.；Sargassum is many Sugar is a kind of immunomodulator, can stimulate various immunologically competent cell maturation, breaks up and breed, and makes body immune system recover flat Weigh or strengthened, body immunologic function.

Resveratrol: resveratrol is present in the Natural antioxidant in plant, main by removing or suppressing freely The mechanisms play antioxidations such as base generates, anti-lipid peroxidation, regulation antioxidation related enzyme activity.Along with development in science and technology, Various radiation, the use of electrical equipment, the impact of PM2.5, make female body be chronically at oxidative stress status, produce damage, white Herba chenopodii Reed alcohol is for removing free radical, and suppression vivo oxidation reacts, and reduces internal low hemolysis rate, and effectively protection red blood cell structure is complete Property, suppress H₂O_2­Destroying damage to biomembranous, maintain blind report normal physiological function, its effect is better than VC, VE.

Citrus flavonoids: be the fully natural green compound extracted from peel of Citrus reticulata Blanco, is a series of to have notable biology The mixture that the flavone compound of activity is formed, has free radical scavenging activity, and its mechanism of action is directly to remove Active oxygen and destruction free radical chain reactions, Flavonoid substances has rise non-oxidizability enzymatic activity, enhancing body antioxidation energy The effect of power.Not only there is the armaticity of uniqueness, good water solublity and significantly pharmacological action, and be that a class is newfound Nutrient.Clinical research confirmation, Flavonoid substances is pharmacologic agents and important trophic factors.Citrus flavonoids

Arginine: arginine can produce hormone with positions such as stimulating pancreas, adrenal gland, thalamuses, and arginine is to prolactin antagonist and growth The condition of hormone is the most crucial, and animal is by growth hormone and insulin like growth factor regulation protein and amino acid metabolism.

Inositol: inositol participates in internal metabolic activity, can synthesize the precursor substances such as creatine phospholipid, membrane phospholipid, sphingomyelins, Required for the growth of mankind's various kinds of cell.

Vitamin E: a kind of powerful antioxidant, can stop becoming sour of fatty acid in food and digestive tract effectively, and protection is thin Born of the same parents are from unsaturated fatty acids acid oxidase；Promote the secretion of pituitary gonadotropic hormone；Reduce the generation of lipid peroxide, protect body Cell is from the murder by poisoning of free radical；Improve immunity of organisms；Slow down aging, prophylaxis of cancer and multiple chronic disease.

The reproductive performance of vitamin E and female mammal has close relationship, can the function of Stimulation of Pituitary Gland frontal lobe live Dynamic, promote that secretory cell secretion promoting sexual gland hormone increases, thus regulate growth promoter and the functional activity of gonad, as strengthened ovary Physiological function, make follicle increase and lutein cell increase and make the effect of progesterone strengthen, prevent miscarriage, raising litter size, drop Low young baby's Preweaning death rate.In addition vitamin E can promote that cell nRNA updates and protein synthesis, promotes some pheron Synthesis.

Vitamin E and vitamin C are all antioxidants, can effectively act as anti-oxidative damage when being used alone, and strengthen Body's immunities etc. act on.Their antioxidant effect can be strengthened when two kinds of vitamin are used in combination.Vitamin E and selenium exist Playing synergism in antioxidation, vitamin E can regard the first line of defence preventing peroxide from generating as, containing selenium GSH-xP plays a part second defence line, the integrity of the plasma structure of common protection cell membrane.

Vitamin C: it is the most essential to the growth promoter of animal, breeding, health that vitamin C is also called ascorbic acid, one Aspect participates in substance metabolism as the cofactor of desmoenzyme, on the other hand as the important antioxidant of intraor extracellular, anti- Immunity etc., stress be regulated functionally play an important role.

In jenny blood plasma, the level of vitamin C rises to the highest in period of becoming pregnant, and this prompting vitamin C is at this During important function.Containing substantial amounts of ascorbic acid in rat ovary preovulatory follicle, research shows, high-caliber dimension is raw Element C can prevent the apoptosis of follicle.

Vitamin B₁: vitamin B₁Form phosphorylated thiamine in vivo, act on the coenzyme of α-keto acid oxidative deamination enzyme system In involved in sugar metabolism, the oxidative deamination reaction of 2-ketoacid, activates choline acetylase simultaneously and suppresses choline to refer to the activity dimension of enzyme Hold the function of choline nervous system, digestive system and cardiovascular system.Human body every day is to vitamin B₁Need for 1mg, Yun Fuji Child needs some more, if vitamin B₁Lack, then metabolism obstacles of blood glucose, energy can be caused to reduce, cardiovascular system, digestive system merit Obstacle can be arisen that, show various clinical symptom.

Vitamin B₂: vitamin B₂Food exists with the combining form such as free state or phosphate ester, meeting after absorption of human body It is phosphorylated at liver, changes into flavin mononucleotide (FMN) (FMN), after resupplying energy, change into flavin adenine dinucleotide (FAD) (FAD), they have redox in biological oxidation process.China's population famine vitamin B₂, long-term lacking Or supplement deficiency, it will occurring that energy is not good, fatiguability, dizziness, lip are dry and cracked, decortication, oral ulcer, tongue are rubescent or purple The phenomenons such as red, skin is itched, hypoevolutism.

Human body cannot self synthetic vitamin B₁And vitamin B₂, so can only be supplemented by pickuping food, but along with Growth in the living standard, the essence of food is run business into particular one and is eaten, and has and has much run off.Therefore will be by additionally taking this biostearin, to reach Intake to needed by human body.

Vitamin B₆: vitamin B₆It is the coenzyme of multiple enzyme during folic acid metabolism, simultaneously participates in the metabolism of nucleic acid, thus It is immunologically competent cell breeding and the immunoglobulin indispensable nutrient of synthesis, increases vitamin B₆Intake and reduction There is certain relation in Incidence of CHD, multinomial research proves vitamin B₆Elderly brain function tool is had a certain impact.

Animal experiment finds, vitamin B₆Shortage can cause filial mice to produce the birth defects such as cleft palate, exencephalia and abdominal hernia.Have Case control study shows, mother of children with congenital heart disease in the pregnancy period, its take in vitamin B₆And vitamin B₁₂Will Less than Normal group.

Vitamin B₁₂: vitamin B₁₂Also known as cyanocobalamin, also referred to as animal protein factor, is that a class contains similar cyanogen cobalt The general name of amine element vitamin active material.It is the water soluble vitamins uniquely containing metal ion, is again the dimension of needed by human One of raw element.Its main Physiological Function has following several respects: one is to improve folic acid utilization rate, synthesizes methionine together with folic acid (being synthesized by homocysteine) and choline, synthesize cobalamin Shen base precursor materials such as methyl cobalt during producing purine and pyrimidine Amine and coenzyme B₁₂, participate in the methylation procedure of many important compound.Two is metabolism and the function safeguarding neural myelin.Lack dimension Raw element B₁₂Time, neurological disorder, spinal cord degeneration can be caused, and serious mental symptom can be caused.Vitamin B₁₂Lack and may result in week Enclose neuritis.Three is to promote erythrocytic growth and maturation.Methylmalonyl CoA is changed into S-(3-carboxy-propionyl)-coenzyme-A, participates in three Carboxylic acid recycle, wherein S-(3-carboxy-propionyl)-coenzyme-A is relevant with the synthesis of haemachrome.Four is vitamin B₁₂Also participate in desoxyribose (DNA) Synthesis, fat, carbohydrate and the metabolism of protein, increase the synthesis of nucleic acid and protein.

Beta-carotene: beta-carotene can be as the approach of acquisition vitamin A, and vitamin A is necessity of manufacturing hormone One of raw material；It is one of antioxidant maximally effective to free radical resisting, interior free yl, singlet-oxygen quenching can be removed, increase Strong intercellular communication, and then there is raising body immunity, prophylaxis of tumours, thrombosis, atherosclerosis, prostatosis, Strengthen reproductive system and urinary system function, improve motility of sperm and defying age, assist in keeping the lubrication of cornea and transparent Degree, the health of promotion eyes and improvement and strengthening respiratory system function.

Research finds that vitamin A metabolism disorder in vivo is closely related with zinc deficiency, because zinc participates in vitamin in liver The composition of A reductase, when zinc deficiency, in hyperamization, vitamin content reduces, and the turnover rate of plasma vitamin A reduces, and causes endogenous Property transport the most optimum vitamin A lack, cause the shortage of vitamin A.The epithelial cell generation pathological changes of reproductive system can affect Vagina, ovary, cause glandular secretion to reduce, ovulation failure.

Folic acid: folic acid, as maintaining a type organic matter necessary to organism normal living process, is generally inhaled by body After receipts, become at least 5 kinds of activated co-enzyme form, to the biosynthesis of purine, pyrimidine, nucleic acid and protein and cell Merisis has the effect of particular importance.The physiological function of folic acid is；1. purine and the formation of pyrimidine in nucleic acid synthesis is participated in, Effect is had in cell division and breeding；2. the composition containing Ferri-hemoglobin is constituted；3. two carbon aminoacid and three carbon aminoacid are made Mutually conversion；4. the conversion of phenylalanine and tyrosine, histidine and glutamic acid, cysteine and methionine can be promoted；5. make Ethanolamine is converted into N-methylnicotinamide；6. folic acid can provide a large amount of free carbon ion, supply manufacture nerve ending and constitute biography Pass the important raw chemical material of neural impulse, carry out the normal development of warrantor's somatic nervous system.

Numerous studies confirm, in anemia of pregnant woman's body, folic acid deficiency is neural tube defects (neural tube de2fects, NTDs) An important risk factor, mother pregnancy period orga-nogenesis critical period augment folic acid can effectively reduce fetus occur The danger of NTDs.Additionally, pregnancy period supplement folic acid is also possible to reduce what the deformity such as fetal congenital heart disease, harelip occurred Dangerous.Therefore women's pregnancy period augments folic acid is prevention NTDs and the important formulation of first grade of preventive measures of other severe deformities.Beautiful Academy of science of state suggestion women of child-bearing age's meals every day folic acid recommended intake in 1998 is 400 μ g, in pregnancy period morning, noon and afternoon in each stage anemia of pregnant woman Being 600 μ g, the highest permission every day intake of folic acid is 1000 μ g.

Ferrum: ferrum participates in the synthesis in vivo of hemoglobin, Myoglobin, makes oxygen and nutrient normal transport in vivo, storage, Internal carbon dioxide is made to be discharged by body；It can constitute cytochrome and cytochrome oxidase, participates in body electron transmission, right Breathe and energy metabolism all produces material impact；Internal multiple enzymes activity is all relevant to ferrum, is catalyzed multiple redox reaction Enzyme all contain ferrum；Enzyme and other factors of having more than 1/2 in the most internal tricarboxylic acid cycle are filled at environment or the ferrum of iron content Competence exertion biochemical action in the case of foot, completes physiological function.Iron deficiency may result in human physical power's decline, work capacity and operation Ability substantially weakens, immunity significantly reduces, and also can produce women 's fertility and have a strong impact on.

The main cause causing anemia is trophic factor, and the source of human body 40% ferrum is poultry meat, Fowl meat, flesh of fish group food, for Heme iron, absorbance is 25%, and the iron absorptivity of Grain legumes is only 2-5%.Ferrum element is important nutrition necessary to human body Element, iron deficiency can cause degradation many-side impact under anemia, blood fortune oxygen ability, intelligence, special for being standby pregnancy period and pregnancy period If women's ferrum element lacks, the anemia of fetus and baby can be caused, affect the secretion of breast milk, it is therefore desirable to actively in added body The utilization rate of ferrum, meanwhile, supplements ferrum element when anemia is with vitamin A deficiency, hemoglobin can not recover normal completely, needs Vitimin supplement A, to reach to recover the purpose of hemoglobin；Vitamin B₁₂, folic acid deficiency also can affect erythrocytic conjunction Become^[34]；Vitamin C is the important nutrient promoting ferrum element to absorb, and supplements multivitamin and mineral meeting the most simultaneously More more effective than single iron supplement anemia.

Selenium: selenium is one of necessary 14 kinds of trace element of human body, owing to trace element is as enzyme, hormone, vitamin, core The composition of acid, the metabolic process sustained life, there are ratio protein, fat, the prior Nutrition of vitamin, and body self Can not manufacture, it is necessary to take from the external world, trace element-selenium by being combined with protein and other organic groups, define enzyme, hormone, The macromole such as vitamin, play important biochemical functions^[36].Selenium is the required trace unit in human embryos generating process Element, owing to selenium participates in multiple important enzyme and the synthesis of protein, has important impact to fertility.High selenium regional population's high birth rate In low selenium area, the female animal of selenium deficiency oestruses disorder, and pregnancy rate is low, the most infertile, gestation female animal generation premature labor, miscarriage and dead Tire.After cow selenium supplement, its rate of fertilization is 100%, and selenium supplement person rate of fertilization is not 41%.

Zinc: zinc be distributed in animal body institute in a organized way in, wherein with organ groups such as muscle, skeleton, liver, skin and hairs Content in knitting is the highest, and the zinc content of other tissue is all closer to.Trace element zinc mainly passes through carbonic anhydride The multiple enzymes such as enzyme, alkaline carbonic acid enzyme, lactic acid dehydrogenase, glutamte dehydrogenase, DNA polymerase, RNA polymerase participate in nucleic acid The biochemical metabolism processes such as synthesis with protein, energy metabolism, oxidoreduction, and then affect the substance metabolism of body and animal Growth promoter.

The change of 116 example female acyesis patient's Trace elements content studies trace element to women not clinically The pregnant zinc deficiency that affects is disadvantageous to mammiferous reproductive function.Body is when zinc deficiency, and hypophysis cerebri synthesis stimulates with secretion follicle Element and the function reduction of lutropin, hypothalamus synthesis secretion luteinizing hormone releasing hormone (LRH) function also declines simultaneously, Can affect the maturation of oocyte, i.e. in mid-term secondary oocyte, the oocyte quantity of degeneration increases by one than time normal Times.

Compatibility of the present invention illustrates:

Resveratrol is present in the Natural antioxidant in plant, and Sargassum polysaccharides is the weight extracted from marine algae material The active substance wanted, Sargassum polysaccharides compound can not only control cell division, but also have regulation cell growth to remain raw The important function such as life organism homergy, Sargassum polysaccharides can promote that proliferation of mouse T lymphocytes reacts, and has immunity tune to cell The multiple efficacies such as joint, antitumor, mutation, Cell differentiation inducing activity, antiviral.Resveratrol and Sargassum polysaccharides all have preferably Antioxidant effect, but composite antioxidant is higher compared to the antioxidant activity of single antioxidant, can avoid antioxidant mistake Many and the safety problem brought.

Citrus flavonoid substance has higher non-oxidizability than vitamin E, the Oxidation that two kinds of materials combine, Synergy is the most obvious.Vitamin E and vitamin C are all antioxidants, can effectively act as antioxidation when being used alone Damage, enhancing human body immunity function etc. acts on.Their antioxidant effect can be strengthened when two kinds of vitamin are used in combination.Dimension is raw Element E plays synergism with selenium in antioxidation, and vitamin E can regard the first line of defence preventing peroxide from generating as, GSH-xP containing selenium plays a part second defence line, the integrity of the plasma structure of common protection cell membrane.

If standby pregnancy period and pregnant women ferrum element lack, the anemia of fetus and baby can be caused, affect the secretion of breast milk, It is thus desirable to the utilization rate of ferrum in positive added body, meanwhile, when anemia is with vitamin A deficiency, supplement ferrum element, hemoglobin Can not recover normal completely, require supplementation with vitamin A, to reach to recover the purpose of hemoglobin；Vitamin B₁₂, folic acid deficiency also Erythrocytic synthesis can be affected；Vitamin C is the important nutrient promoting ferrum element to absorb, and supplements multiple dimension raw the most simultaneously Element and mineral can be more more effective than single iron supplement anemia.

Human body cannot self synthetic vitamin B₁And vitamin B₂, so can only be supplemented by pickuping food, but along with Growth in the living standard, the essence of food is run business into particular one and is eaten, and has and has much run off.Therefore will be by additionally taking this biostearin, to reach Intake to needed by human body.

Above the better embodiment of this patent is explained in detail, but this patent is not limited to above-mentioned embodiment party Formula, in the ken that one skilled in the relevant art is possessed, it is also possible on the premise of without departing from this patent objective Make a variety of changes.

Claims (3)

1. one kind is applicable to the soft capsule that woman preparing for pregnancy is taken, it is characterised in that be made up of according to weight portion following material: sea Algae extract 0.9-5 part, resveratrol 1.3-5 part, vitamin C 60-80 part, vitamin E 30-40 part, vitamin B₁ 1-2 Part, vitamin B₂1-2 part, vitamin B₆1-2 part, vitamin B₁₂0.0015-0.0025 part, folic acid 0.325-0.4 part, β- Carotene 10-50 part, sodium selenite 9-20 part, zinc sulfate 20-75 part, ferrous fumarate 55-80 part, soybean oil 400-650 Part, soybean phospholipid 20-40 part, Cera Flava 20-40 part, citrus flavonoids 5-25 part, arginine 10-30 part, inositol 15-30 part.

The most according to claim 1 it is applicable to the soft capsule that woman preparing for pregnancy is taken, it is characterised in that pressed by following material Form according to weight portion: Sargassum extract 1.9-4 part, resveratrol 2.3-4 part, vitamin C 65-75 part, vitamin E 33-37 Part, vitamin B₁1.3-1.7 part, vitamin B₂1.3-1.7 part, vitamin B₆1.3-1.7 part, vitamin B₁₂ 0.0018- 0.0022 part, folic acid 0.35-0.375 part, beta-carotene 30-40 part, sodium selenite 12-17 part, zinc sulfate 35-60 part, rich horse The ferrous 65-70 part of acid, soybean oil 450-600 part, soybean phospholipid 25-35 part, Cera Flava 25-35 part, citrus flavonoids 10-20 part, Arginine 15-25 part, inositol 18-27 part.

3. the preparation method being applicable to the soft capsule that woman preparing for pregnancy is taken as described in claim 1-2 is arbitrary, it is special Levy and be, comprise the following steps:

(1) preparation of Sargassum extract: take a certain amount of Sargassum, adds a certain amount of cellulase, is dissolved in water, and regulates ph= 5.3, after constant temperature enzyme a period of time at a certain temperature, it is warming up to 100 DEG C of heating 5min and makes enzyme inactivate, cold filtration, concentrate, add Entering dehydrated alcohol to determining alcohol is 80%, stands, centrifugal, obtains Sargassum extract；

(2) preparation of citrus flavonoids: the ethanol water of size-reduced Citrus powder and 75% is put for 1:1-5 by weight In extractor, extract 0.5-1 hour at reflux, repeat 2-3 time, merging filtrate, concentrated, dry, obtain Citrus Flavonoid extract；

(3) dispensing: by prescription requirements, by Cera Flava by a certain amount of soybean oil heating for dissolving, controls temperature at 70-75 DEG C, after dissolving Adding soybean phospholipid mix and blend 15min, rotating speed is 35rpm, then by Sargassum extract, resveratrol, inositol, arginine, Vitamin E, vitamin C, vitamin B₁, vitamin B₂, vitamin B₆, vitamin B₁₂, folic acid, beta-carotene, vitamin E, richness Horse acid ferrous iron, sodium selenite, zinc sulfate add stir about 30min in mixed material, rotating speed 35rpm, evacuation (vacuum after stirring Degree-0.08Mpa, time 15-30min), keep about 30-40 DEG C, sieve 80 mesh；

(4) colloidal sol: put into recipe quantity purified water, glycerol in changing glue tank, stir to being completely dissolved under the conditions of 65 DEG C, then input is joined Side's amount gelatin and pigment, be warming up to 75-80 DEG C, and (vacuum is-0.08MPa, the time for stirring and dissolving 60-80 minute, evacuation 30-40 minute) to glue bubble-free, then glue is crossed 120 mesh sieves and releases glue, stand more than 4 hours, keep glue 45- About 60 DEG C, stand-by；

(5) pelleting: check capsule 's content to be pressed and the glue name of an article, specification, lot number etc., carry out pelleting with soft capsule filling machine, Regulation rubber thickness (0.70-0.80mm), controls content content uniformity.