CN105687035A - Compound ginkgo essential oil with effects of resisting oxidation and delaying skin aging - Google Patents
Compound ginkgo essential oil with effects of resisting oxidation and delaying skin aging Download PDFInfo
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Abstract
The invention belongs to the technical field of essential oil, and particularly relates to compound essential oil with ginkgo essential oil and effects of resisting oxidation and delaying skin aging.The compound essential oil with the ginkgo essential oil comprises, by weight, 8-15 parts of the ginkgo essential oil, 30-60 parts of grape seed essential oil, 10-30 parts of lavender essential oil, 2-8 parts of tea tree essential oil, 2-8 parts of tea polyphenols and 0.3-3 parts of humectants.The humectants are polyols humectants.The invention further provides a method for preparing the compound essential oil with the ginkgo essential oil and the effects of resisting oxidation and delaying skin aging.The compound essential oil with the ginkgo essential oil and the method have the advantages that the contents of hydroxyproline (HYP) and superoxide dismutase (SOD) in the skins of users can be obviously increased by the compound essential oil with the ginkgo essential oil, malondialdehyde (MDA) and lipofuscin (LF) values can be lowered, and accordingly the compound essential oil has free radical removing, moisture preserving and water locking functions and can be used for delaying skin aging; the compound essential oil with the ginkgo essential oil is difficult to volatilize and is long in shelf life.
Description
Technical field
The invention belongs to quintessence oil technical field, be specifically related to a kind of composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect。
Background technology
Ginkgo has another name called maidenhair tree, is the rarity of China, rare valuable, is described as " hollywood lignumvitae ", " living fossil " of the earth, and its leaf, fruit, seed have the medical value that comparison is high, and its pharmacological action is constantly realized, and clinical application range progressively expands。Research shows, Ginkgo biloba leaves and in fruit containing flavone, terpene lactone, main effective active composition such as phenol and phenolic acids, polysaccharide and Polyprenol etc., and the composition such as a small amount of quininic acid, linoleic acid, vitamin, ascorbic acid and alkaloid。Wherein, flavone, terpene lactone, phenol and phenolic acids are in the news and have antioxidation, scavenging free radicals, the effect that antiinflammatory is antibacterial, has positive effect to improving disordered brain function, arteriosclerosis, hypertension, dizziness, tinnitus, headache, senile dementia, hypomnesis etc.。
In recent years, the developmental research to gingko resource, it is concentrated mainly on Folium Ginkgo。In the utilizing of ginkgo nut, based on outlet or domestic dry fruit, consumption is concentrated mainly on leisure food aspect。Such as, the preparation method that Chinese patent literature CN102160662B " preparation method of a kind of leisure ginkgo nuts " namely discloses a kind of leisure ginkgo nuts。Chinese patent literature CN101305777B then discloses the manufacture method of a kind of gingko pulp paste。Food containing gingko almond and Folium Ginkgo all have abundant active beneficial, therefore, extracts, prepare ginkgo oil and Related product causes the attention of scientific research personnel。Such as, Chinese patent application document CN103039961A " a kind of ginkgo oil microcapsules and preparation method " namely discloses a kind of efficient, ginkgo oil microcapsules of making Semen Ginkgo extrac be fully used and preparation method thereof。Utilize microcapsule technology to overcome Semen Ginkgo fractions of active ingredient and meet that shipwreck is molten, bitter in the mouth, it is impossible to the problem directly eaten。Also have Chinese patent application document CN101214046A " a kind of method for preparing ginkgo biloba oil powder " to adopt micro encapsulation embedding techniques to produce ginkgo biloba oil powder, ginkgo oil effective ingredient is used for the fields such as nutraceutical, health food, cosmetics, medicine。Also have Chinese patent application document CN102742902A " preparation method of a kind of gingkgo water " that by certain part by weight proportioning, ginkgo oil and Pulvis Talci and water are prepared a kind of gingkgo water, take needs with what adapt to different crowd。But ginkgo oil is mainly made medicine or food to reach certain therapeutic purposes with oral form by the said goods。
It is true that have very strong scavenging free radicals and antioxidation due to Semen Ginkgo extrac, yellow glycoside in Folium Ginkgo, aminoacid and Amino acid synthesis collagen protein composition are to human body beauty treatment, it is suppressed that melanin grows, and keep skin gloss and elasticity to have important effect。And, Semen Ginkgo is applied to cosmetics early has pertinent literature to report。Such as, Chinese patent CN102988264B " Folium Ginkgo freckle removing and whitening frost and preparation method thereof " namely discloses a kind of Semen Ginkgo freckle removing and whitening frost。The preparation method of its offer overcomes the poisonous defect that should not extract of Folium Ginkgo, remains the beneficiating ingredient of Folium Ginkgo greatly, on the make avoids secondary pollution, is the cosmetics of complete green health environmental protection。Chinese patent CN103387896B " Folium Ginkgo whitening composite soap " then discloses a kind of Folium Ginkgo whitening composite soap。This invention adds the additives such as antibacterial, antioxidant, preservative in Folium Ginkgo extract and makes skin irritation is low, energy skin whitening composite soap。
Quintessence oil, is from the flower of plant, leaf, stem, root or fruit, is refined the volatile flavor extracted by steam distillation, squeezing and pressing method, cold-maceration or solvent extraction method。Quintessence oil has lipotropy, so being easy to permeate in skin, entering internal by means of blood capillary abundant under subcutaneous fat, improving the metabolic effect of local organization thus playing。It is usually used in sterilization antiinflammatory, improves the aspects such as skin, toxin expelling, pleasure。
But up to now, yet there are no and the effective active composition of Semen Ginkgo is made quintessence oil be used for improving skin, the report of delaying skin aging aspect。
Summary of the invention
In order to solve the above-mentioned problems in the prior art, an object of the present invention is to provide one can improve skin, has the composite essential oil containing Semen Ginkgo quintessence oil eliminating free radical, antioxidation, delaying skin aging effect。
It is a further object to provide a kind of method preparing the above-mentioned composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect。
In order to realize foregoing invention purpose, one technical scheme of the present invention provides a kind of composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect, it includes each component of following weight portion: Semen Ginkgo quintessence oil 8-15 part, Semen Vitis viniferae quintessence oil 30-60 part, Garden lavender quintessence oil 10-30 part, tea tree ethereal oil 2-8 part, tea polyphenols 2-8 part, wetting agent 0.3-3 part, wherein, described wetting agent is polyalcohols wetting agent。
Preferably, described wetting agent is C2-6One or more in polyhydric alcohol。
It is further preferred that described wetting agent is one or more in propylene glycol, dipropylene glycol, glycerol, diglycerol, butanediol, pentanediol and sorbitol。
It is further preferred that described wetting agent is dipropylene glycol and propylene glycol。
Preferably, described in have antioxidation, delaying skin aging effect containing the composite essential oil of Semen Ginkgo quintessence oil, it includes each component of following weight portion: Semen Ginkgo quintessence oil 15 parts, Semen Vitis viniferae quintessence oil 30-60 part, Garden lavender quintessence oil 10-30 part, tea tree ethereal oil 2-8 part, tea polyphenols 2-8 part, wetting agent 0.3-3 part。
Further preferably, the described composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect, it includes each component of following weight portion: Semen Ginkgo quintessence oil 15 parts, Semen Vitis viniferae quintessence oil 50-60 part, Garden lavender quintessence oil 20-30 part, tea tree ethereal oil 5-8 part, tea polyphenols 5-8 part, wetting agent 0.3-0.5 part。
It is further preferred that a kind of composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect, it includes each component of following weight portion: Semen Ginkgo quintessence oil 15 parts, Semen Vitis viniferae quintessence oil 60 parts, Garden lavender quintessence oil 30 parts, tea tree ethereal oil 8 parts, tea polyphenols 8 parts, propylene glycol 0.3 part。
Another technical scheme of the application provides a kind of method preparing the above-mentioned composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect, and it carries out according to following steps:
1. preparation Semen Ginkgo quintessence oil
1) dry Folium Ginkgo and ginkgo nut are pulverized with weight ratio for 1:0.2-1 mix homogeneously, cross 20-50 mesh sieve and be placed on extraction kettle；
2) in extraction kettle, input supercritical carbon dioxide fluid, extracting pressure to be 25-35MPa, extraction temperature be 32-50 DEG C, the flow velocity of carbon dioxide extract when being 20-60kg/h, extraction time is 3-8h；
3) CO 2 fluid after extracting being passed into successively in primary separator, second-stage separator and is easily separated, the flow velocity of carbon dioxide is 10-30kg/h, and wherein, primary separator pressure is 4-6MPa, flash trapping stage actuator temperature 0-15 DEG C；Second-stage separator pressure 5-7MPa, the second-order separation actuator temperature 22-40 DEG C；Wax component is discharged from primary separator；From second-stage separator, discharge ginkgo oil, heating demulsification type, after separating aqueous phase, obtain described Semen Ginkgo quintessence oil；
2. the preparation composite essential oil containing Semen Ginkgo quintessence oil
Semen Ginkgo quintessence oil, Semen Vitis viniferae quintessence oil, Garden lavender quintessence oil, tea tree ethereal oil, tea polyphenols and wetting agent is weighed according to above-mentioned formula ratio, by the Semen Ginkgo quintessence oil of formula ratio and Semen Vitis viniferae quintessence oil Homogeneous phase mixing at 0-30 DEG C, it is subsequently adding the Garden lavender quintessence oil of formula ratio, tea tree ethereal oil, tea polyphenols and wetting agent, stirring to each component merges completely, obtains the described composite essential oil containing Semen Ginkgo quintessence oil。
Preferably, extraction kettle in step 1) is also added with entrainer and has carried out step 2) front first soak described Folium Ginkgo and ginkgo nut mixture 2-5h, the weight ratio of described entrainer and Folium Ginkgo and ginkgo nut mixture is 1:200-500, and described entrainer is acetone: ethanol: methanol: ethyl acetate: acetic acid=1:2:1:1:0.005-0.02(volume ratio) mixture。
Active component ginkgetin in Semen Ginkgo quintessence oil can accelerate cell metabolism, improves blood circulation, strengthens cell viability, by helping blood vessel to recover elastic force, promotes the blood circulation of tiny blood vessels, delaying cell aging；
Active component bilobalide in Semen Ginkgo quintessence oil can protect the vascular endothelial cell of oxidativestress damage, plays suppression H2O2The effect of the cell death caused by (a kind of important active oxygen species at extracellular inducing cell apoptosis, can simultaneously facilitate hydroxy radical and produces, inducing cell lipid peroxidation, causes that endotheliocyte is impaired and dead)；And flavonoid and bilobalide can work in coordination with the ultra-oxygen anion free radical in scavenger cell tissue and hydroxyl radical free radical, play the effect of delaying skin aging。
Semen Vitis viniferae quintessence oil mainly contains the compositions such as linoleic acid, procyanidin, linoleic acid, vitamin B, for it have been recognized that the removing maximally effective Natural antioxidant of people's interior free yl。Due to characteristics such as its tenderness, little, the easy absorptions of zest, mix with other quintessence oil, it is possible to play diluting effect。
Garden lavender quintessence oil can quickly enter hair follicle, remove deposit in hair follicle, dredging pore removes excess oil, play the effect of cleaning skin, also there is the epidermis skin that compacts simultaneously, restrain pore, suppress epidermis oils and fats excessive secretion, prevent from again being formed corse sweat pore, promote cell regeneration, improve skin obscure, dry, aging。
Tea polyphenols is the general name of Polyphenols of Tea, including flavanol compound, anthocyanin class, flavonoid, flavonols and phenolic acids etc.。Tea polyphenols has the effect of scavenging free radicals, can suppress lipoxygenase and lipid peroxidation in skin line plastochondria, thus producing defying age effect。And, the antioxygen property of tea polyphenols plays synergy with the injection Vitamin B_6 of existence in other quintessence oil。
In tea tree ethereal oil, topmost chemical composition is ethylene, dipentene, limonene, cineol, Oleum sesami brain, anisoxide。Tea tree ethereal oil abnormal smells from the patient delicate fragrance, uniqueness are strong, and it has the advantages such as the antimicrobial acivity of All Pure Nature, sterilization, antibacterial activity, nonirritant, excellent percutaneous permeability。It can treat acne and sore, comedo, mosquito bite, trick tinea etc., and seasick carsick symptom is also effective in cure, can with fixed attention, mix uses with other quintessence oil, it is possible to play the effect that collaborative promotion is permeated。
Wetting agent is auxiliary agent conventional in cosmetics preparation process, is used for increasing skin surface moisture。Polyalcohols wetting agent is one of conventional wetting agent。Because the polyhydroxy structure in polyol molecule so that it is moisture can be absorbed from surrounding, thus playing the effect of moisture-absorbing moisture-keeping。Meanwhile, polyalcohols may also operate as the effect of preservative, and this is owing to this kind of material can be had an effect with the cell membrane of antibacterial, causes its cell membrane arrangement disorder or breakage, and then makes that antibacterial is injured loses its physiological function, plays antiseptical effect。Additionally, due to the highly polar effect of hydroxyl, it is easy to produce intermolecular interaction with other component (such as phenols, acids), play the effect of hydrotropy。For volatile material, due to intermolecular interaction, it is possible to play minimizing quintessence oil effective ingredient volatilization, extend the effect of quintessence oil shelf-life。
Each component in the composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect provided by the invention can suppress epidermis oils and fats excessive secretion on the one hand, internal free radical, dredging pore is eliminated while cleaning skin, make collaborative infiltration deep skin of the nutrient substance in quintessence oil (skin corium and basal layer), play moisturizing, whitening, crease-resistant effect；On the other hand, should can work in coordination with played a role containing each component in the composite essential oil of Semen Ginkgo quintessence oil, the nutrient substance that wetting agent highly polar can be highly polar with other, such as alcohols, acids, interact, reduce the volatilization of effective ingredient, antisepsis can also be played, extend the shelf-life of quintessence oil。
Component Semen Ginkgo quintessence oil in the composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect provided by the invention is with the mixture of Folium Ginkgo and ginkgo nut for raw material, utilize carbon dioxide supercritical extraction method to extract to obtain, gingko resource can be made full use of, more fully extract effective ingredient therein；It addition, add polarity entrainer in extraction process, can farthest extract effective ingredient therein。
Provided by the invention have antioxidation, can the using containing the composite essential oil of Semen Ginkgo quintessence oil of delaying skin aging effect by following common usage: 1) massage uses, every 10mL emulsion adds 20-30 and drips the above-mentioned composite essential oil containing Semen Ginkgo quintessence oil, fully mixing, carries out skin massaging；2) use with Sprayable after dilution, every 10mL pure water or distilled water add 20-30 and drips the above-mentioned composite essential oil containing Semen Ginkgo quintessence oil, fully shake up, carry out spraying diffusion；3) pick with instruments such as cotton swabs and directly smear in face a little, massage gently；4) take 20-30 to drip in the above-mentioned composite essential oil containing Semen Ginkgo quintessence oil instillation facial film, spread on face 10-15 minute。
Composite essential oil containing Semen Ginkgo quintessence oil provided by the invention can significantly improve the hydroxyproline (HYP) in skin, superoxide dismutase (SOD), content, reduce malonaldehyde (MDA) and lipofuscin (LF) value, there is the function eliminating free radical, moisturizing, lock water, can be used for delay skin aging。And, the composite essential oil that should contain Semen Ginkgo quintessence oil is not volatile, long shelf-life。
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further elaborated。These embodiments are only for illustrative purposes, and do not limit the scope of the invention and essence。
Consider vegetatively, the factor impact on Folium Ginkgo and ginkgo nut effective ingredient such as growth conditions, the Folium Ginkgo used by the present invention is pick up from Guizhou Zhengan County in April, 2015, the tender leaf of the raw ginkgo of 2-3。Ginkgo nut is the mature fruit picking up from identical ginkgo October。
Semen Vitis viniferae quintessence oil used in the present invention, Garden lavender quintessence oil, tea tree ethereal oil and tea polyphenols all are undertaken extracting or directly buying finished product from market by this area routine techniques means；Wetting agent is then for directly to buy from market, and specification is analytical pure。
Embodiment 1
A kind of composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect, it includes each component of following weight portion: Semen Ginkgo quintessence oil 15 parts, Semen Vitis viniferae quintessence oil 60 parts, Garden lavender quintessence oil 30 parts, tea tree ethereal oil 8 parts, tea polyphenols 8 parts, propylene glycol 0.3 part。
Wherein, component Semen Ginkgo quintessence oil prepares in accordance with the following steps:
1) dry Folium Ginkgo and ginkgo nut are pulverized with weight ratio for 1:0.2 mix homogeneously, cross 20 mesh sieves and be placed on extraction kettle, the ratio being 1:500 with the weight ratio of entrainer with Folium Ginkgo, ginkgo nut mixture wherein adds entrainer, and entrainer is acetone: ethanol: methanol: ethyl acetate: acetic acid=1:2:1:1:0.01(volume ratio)；By continuously stirred for said mixture immersion 3h；
2) in extraction kettle, input supercritical carbon dioxide fluid, extracting pressure to be 35MPa, extraction temperature be 32 DEG C, the flow velocity of carbon dioxide extract when being 20kg/h, extraction time is 8h；
3) CO 2 fluid after extracting being sequentially entered in primary separator, second-stage separator and is easily separated, the flow velocity of carbon dioxide is 10kg/h, and wherein, primary separator pressure is 4MPa, flash trapping stage actuator temperature 0 DEG C；Second-stage separator pressure 5MPa, the second-order separation actuator temperature 22 DEG C；Wax component is discharged from primary separator；From second-stage separator, discharge ginkgo oil, heating demulsification type, after separating aqueous phase, obtain Semen Ginkgo quintessence oil。
By the Semen Ginkgo quintessence oil of formula ratio and Oleum Vitis viniferae Homogeneous phase mixing at 25 DEG C, being then sequentially added into Garden lavender quintessence oil, tea tree ethereal oil, tea polyphenols, propylene glycol, stirring to each component merges completely, subpackage, seals。
Embodiment 2
A kind of composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect, it includes each component of following weight portion: Semen Ginkgo quintessence oil 8 parts, Semen Vitis viniferae quintessence oil 50 parts, Garden lavender quintessence oil 20 parts, tea tree ethereal oil 5 parts, tea polyphenols 5 parts, sorbitol 0.1 part, glycerol 0.2 part, propylene glycol 0.2 part。
Wherein, component Semen Ginkgo quintessence oil prepares in accordance with the following steps:
1) dry Folium Ginkgo and ginkgo nut are pulverized with weight ratio for 1:1 mix homogeneously, cross 50 mesh sieves and be placed on extraction kettle, the ratio being 1:200 with the weight ratio of entrainer with Folium Ginkgo, ginkgo nut mixture wherein adds entrainer, and entrainer is acetone: ethanol: methanol: ethyl acetate: acetic acid=1:2:1:1:0.005(volume ratio)；By continuously stirred for said mixture immersion 3h；
2) in extraction kettle, input supercritical carbon dioxide fluid, extracting pressure to be 25MPa, extraction temperature be 50 DEG C, the flow velocity of carbon dioxide extract when being 60kg/h, extraction time is 3h；
3) CO 2 fluid after extracting being sequentially entered in primary separator, second-stage separator and is easily separated, the flow velocity of carbon dioxide is 30kg/h, and wherein, primary separator pressure is 6MPa, flash trapping stage actuator temperature 15 DEG C；Second-stage separator pressure 7MPa, the second-order separation actuator temperature 40 DEG C；Wax component is discharged from primary separator；From second-stage separator, discharge ginkgo oil, heating demulsification type, after separating aqueous phase, obtain Semen Ginkgo quintessence oil。
The preparation method of the composite essential oil containing Semen Ginkgo quintessence oil is with embodiment 1。
Embodiment 3
A kind of composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect, it includes each component of following weight portion: Semen Ginkgo quintessence oil 15 parts, Semen Vitis viniferae quintessence oil 30 parts, Garden lavender quintessence oil 10 parts, tea tree ethereal oil 2 parts, tea polyphenols 2 parts, glycerol 0.2 part, propylene glycol 0.3 part。
The preparation method of the preparation method of the Semen Ginkgo quintessence oil in the composite essential oil containing Semen Ginkgo quintessence oil and the composite essential oil containing Semen Ginkgo quintessence oil is with embodiment 1。
Embodiment 4
A kind of composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect, it includes each component of following weight portion: Semen Ginkgo quintessence oil 15 parts, Semen Vitis viniferae quintessence oil 50 parts, Garden lavender quintessence oil 20 parts, tea tree ethereal oil 5 parts, tea polyphenols 5 parts, dipropylene glycol 0.4 part, propylene glycol 0.1 part。
The preparation method of the preparation method of the Semen Ginkgo quintessence oil in the composite essential oil containing Semen Ginkgo quintessence oil and the composite essential oil containing Semen Ginkgo quintessence oil is with embodiment 1。
Experimental example 1 becomes sour experiment
Respectively by the composite essential oil containing Semen Ginkgo quintessence oil of embodiment 1-4, carrying out fill with dark brown vial, open wide bottle cap, be placed under room temperature 25 DEG C, relative humidity 75% environment, continuous observation, concrete outcome is shown in table 1 below。
Experimental example 2 Efficacy experiments
Take SPE level health Kunming kind rat 50,180-220g, male and female half and half。60 rats are randomly divided into 4 monthly ages (young control), 12 monthly ages (Normal group), 12 monthly age experimental grouies (basic, normal, high dosage group), often group 10。Rat is under identical natural conditions, and routine raises food drinking-water, and adaptability proceeds by experiment after raising。Test hair 3cm × 3cm that front shaver is sloughed on mouse back centre skin; basic, normal, high dosage component Yong not be coated with (0.01g, 0.1g, 1g) outside the composite essential oil containing Semen Ginkgo quintessence oil of preparation in embodiment 1; it is coated with outside Normal group and young control deionized water, preservative film protection 1h。Smear every day once, smear 1g every time, smear 35 days continuously。By sacrifice after having tested, measure its experiment hydroxyproline (HYP) at skin place, superoxide dismutase (SOD), malonaldehyde (MDA) and lipofuscin (LF) value。
The preparation of Skin Homogenate and the mensuration of HYP, SOD, MDA, LF:
After taking back depilation, skin histology block is about 0.5g, pre-cooled 0.9% sodium chloride solution rinsing, remove subcutaneous fat and other connective tissue, filter paper is wiped dry, weighs, and piece of tissue is poured in homogenate tube after shredding, add pre-cooling 0.9% sodium chloride solution of these 9 times of quality of piece of tissue, within 8 minutes, making 10% tissue homogenate (carrying out in frozen water) with interior cut tissue refiner homogenate so that it is completely broken, cellular content is completely free in the liquid phase。In Skin Homogenate, the mensuration of HYP, SOD, MDA, LF is all measured by this area routine techniques means, and the method building up bio-engineering corporation's test kit description by Nanjing is measured。Wherein, embodiment 1 composite essential oil containing Semen Ginkgo quintessence oil prepared measure in rat skin HYP, SOD, MDA, LF content to affect result as shown in table 2 below:
In table 2 embodiment 1, the composite essential oil containing Semen Ginkgo quintessence oil is on the impact of HYP, SOD, MDA, LF content in rat skin
By upper table 2 it can be seen that the HYP content of Normal group, SOD activity relatively young control decline, MDA and LF content relatively young control dramatically increases；Low dose of the experimental group group substantially same Normal group of effect, and middle and high dosage group is compared with Normal group, then have obvious effect: HYP content, SOD activity relatively matched group increase, MDA and LF content compared with normal matched group reduces。
Test result indicate that, the composite essential oil containing Semen Ginkgo quintessence oil provided in embodiment of the present invention 2-4 also has HYP content in significantly raised skin histology, SOD activity, reduces effect of MDA and LF content。
Above-mentioned example is only used as descriptive purpose, and the scope of the present invention is not limited thereto。Modifying to one skilled in the art and be apparent from, the present invention is limited only by the restriction of scope。
Claims (10)
1. the composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect, it includes each component of following weight portion: Semen Ginkgo quintessence oil 8-15 part, Semen Vitis viniferae quintessence oil 30-60 part, Garden lavender quintessence oil 10-30 part, tea tree ethereal oil 2-8 part, tea polyphenols 2-8 part, wetting agent 0.3-3 part, wherein, described wetting agent is polyalcohols wetting agent。
2. the composite essential oil containing Semen Ginkgo quintessence oil according to claim 1, wherein, described wetting agent is C2-6One or more in polyhydric alcohol。
3. the composite essential oil containing Semen Ginkgo quintessence oil according to claim 2, wherein, described wetting agent is one or more in propylene glycol, dipropylene glycol, glycerol, diglycerol, butanediol, pentanediol and sorbitol。
4. the composite essential oil containing Semen Ginkgo quintessence oil according to claim 3, wherein, described wetting agent is dipropylene glycol and propylene glycol。
5. the composite essential oil containing Semen Ginkgo quintessence oil according to any one of claim 1-4, it includes each component of following weight portion: Semen Ginkgo quintessence oil 15 parts, Semen Vitis viniferae quintessence oil 30-60 part, Garden lavender quintessence oil 10-30 part, tea tree ethereal oil 2-8 part, tea polyphenols 2-8 part, wetting agent 0.3-3 part。
6. the composite essential oil containing Semen Ginkgo quintessence oil according to claim 5, it includes each component of following weight portion: Semen Ginkgo quintessence oil 15 parts, Semen Vitis viniferae quintessence oil 50-60 part, Garden lavender quintessence oil 20-30 part, tea tree ethereal oil 5-8 part, tea polyphenols 5-8 part, wetting agent 0.3-0.5 part。
7. the composite essential oil containing Semen Ginkgo quintessence oil according to claim 6, it includes each component of following weight portion: Semen Ginkgo quintessence oil 15 parts, Semen Vitis viniferae quintessence oil 60 parts, Garden lavender quintessence oil 30 parts, tea tree ethereal oil 8 parts, tea polyphenols 8 parts, propylene glycol 0.3 part。
8. a preparation method for the composite essential oil containing Semen Ginkgo quintessence oil with antioxidation, delaying skin aging effect as described in any one of claim 1-7, it carries out according to following steps:
(1) Semen Ginkgo quintessence oil is prepared
1) dry Folium Ginkgo and ginkgo nut are pulverized with weight ratio for 1:0.2-1 mix homogeneously, cross 20-50 mesh sieve and be placed on extraction kettle；
2) in extraction kettle, input supercritical carbon dioxide fluid, extracting pressure to be 25-35MPa, extraction temperature be 32-50 DEG C, the flow velocity of carbon dioxide extract when being 20-60kg/h, extraction time is 3-8h；
3) CO 2 fluid after extracting being passed into successively in primary separator, second-stage separator and is easily separated, the flow velocity of carbon dioxide is 10-30kg/h, and wherein, primary separator pressure is 4-6MPa, flash trapping stage actuator temperature 0-15 DEG C；Second-stage separator pressure 5-7MPa, the second-order separation actuator temperature 22-40 DEG C；Wax component is discharged from primary separator；From second-stage separator, discharge ginkgo oil, heating demulsification type, after separating aqueous phase, obtain described Semen Ginkgo quintessence oil；
(2) preparation composite essential oil containing Semen Ginkgo quintessence oil
Semen Ginkgo quintessence oil, Semen Vitis viniferae quintessence oil, Garden lavender quintessence oil, tea tree ethereal oil, tea polyphenols and wetting agent is weighed according to above-mentioned formula ratio, by the Semen Ginkgo quintessence oil of formula ratio and Semen Vitis viniferae quintessence oil Homogeneous phase mixing at 0-30 DEG C, it is subsequently adding the Garden lavender quintessence oil of formula ratio, tea tree ethereal oil, tea polyphenols and wetting agent, stirring to each component merges completely, obtains the described composite essential oil containing Semen Ginkgo quintessence oil。
9. preparation method according to claim 8, wherein, extraction kettle in step 1) is also added with entrainer and has carried out step 2) front described Folium Ginkgo and the ginkgo nut mixture 2-5h of first soaking, the weight ratio of described entrainer and Folium Ginkgo and ginkgo nut mixture is 1:200-500。
10. preparation method according to claim 9, wherein, described entrainer is acetone: ethanol: methanol: ethyl acetate: acetic acid=1:2:1:1:0.005-0.02(volume ratio) mixture。
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| CN109793233A (en) * | 2018-07-25 | 2019-05-24 | 上海药辰生物科技有限公司 | A kind of deep working method of ginkgo nut endosperm |
| CN109810789A (en) * | 2018-07-25 | 2019-05-28 | 上海药辰生物科技有限公司 | A kind of extracting method of ginkgo essential oil |
| CN112546205A (en) * | 2020-12-09 | 2021-03-26 | 建昌帮药业有限公司 | Composition with function of improving skin aging and preparation method and application thereof |
| CN114712451A (en) * | 2022-04-08 | 2022-07-08 | 江门海关技术中心 | Additive solution for preventing poultry digestive tract bacterial diseases and preparation method thereof |
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| CN104188033A (en) * | 2014-08-18 | 2014-12-10 | 理想科技集团有限公司 | Radiation-resisting and oxidation-resisting functional beverage and preparation method thereof |
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| CN107802025A (en) * | 2017-12-06 | 2018-03-16 | 湖北中烟工业有限责任公司 | A kind of preparation method of ginkgo biloba p.e and its application in cigarette |
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| CN109793233A (en) * | 2018-07-25 | 2019-05-24 | 上海药辰生物科技有限公司 | A kind of deep working method of ginkgo nut endosperm |
| CN109810789A (en) * | 2018-07-25 | 2019-05-28 | 上海药辰生物科技有限公司 | A kind of extracting method of ginkgo essential oil |
| CN112546205A (en) * | 2020-12-09 | 2021-03-26 | 建昌帮药业有限公司 | Composition with function of improving skin aging and preparation method and application thereof |
| CN114712451A (en) * | 2022-04-08 | 2022-07-08 | 江门海关技术中心 | Additive solution for preventing poultry digestive tract bacterial diseases and preparation method thereof |
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