CN105623995A

CN105623995A - Large-fruited Chinese hawthorn appetizer wine or drink and preparation method thereof

Info

Publication number: CN105623995A
Application number: CN201610125815.1A
Authority: CN
Inventors: 胡伯虎; 胡伟; 胡勇; 胡馨木
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-03-06
Filing date: 2016-03-06
Publication date: 2016-06-01
Anticipated expiration: 2036-03-06
Also published as: CN105623995B

Abstract

The invention discloses a plant wine or drink prompting digestion, and particularly relates to a large-fruited Chinese hawthorn appetizer wine or drink and a preparation method thereof. The large-fruited Chinese hawthorn appetizer wine or drink is prepared from Chinese hawthorn fruits, fried malt, pericarpium citri reticulatae, fried radish seeds, fennel, fructus citrus sarcodactylis, fructus hippophae, liquorice roots, cassia bark, xylooligosaccharide, potassium sorbate, and baijiu with the alcohol content of 38% or grape wine or water. The composition has the obvious effect of increasing the total gastric juice amount, the gastric juice discharge amount and the pepsase discharge amount and the obvious effect of increasing the small intestine propulsion speed of a mouse slow gastrointestinal motility model, which shows that the composition has the effects of promoting digestion and promoting gastrointestinal motility. The large-fruited Chinese hawthorn appetizer wine or drink has the advantages of being safe, effective, free of side effects and the like. The modern advanced ultrasonic extraction technology is adopted for preparing the large-fruited Chinese hawthorn appetizer wine or drink, so that the utilization rate of effective constituents of plants is significantly increased, and energy conservation and environment protection are achieved; radish seeds are subjected to quantitative microwave frying, and the large-fruited Chinese hawthorn appetizer wine or drink is suitable for industrial production, is novel and can fill up the blank of appetizer wine in China.

Description

Fruit of Pashi Pear aperitif and beverage and its preparation method

Technical field

The present invention relates to field of beverage, it is specifically related to the plant liquor of a kind of promoting digestion and beverage and its preparation method Fruit of Pashi Pear aperitif and beverage and its preparation method.

Background technology

Aperitif one word derives from Latin aperare, and justice for " opening ", refers to before the meal, after drunk and can stimulate appetite, open appetite drinks. Middle Ages are born in by aperitif, and people like tasting medicinal liquor in ante prandium or adding the grape wine of spices at that time; Think that some plant always has the effect opening appetite. Aperitif has just become integral part indispensable in doings, family life; If asking someone to have a meal and do not ask him to drink one glass of aperitif, this kind of situation is incredible, and aperitif is inherently a kind of please. The kind of aperitif has tens kinds in west. Aperitif product traditional abroad are mainly divided into 3 types: Vermouth, Bitters, mattress cordiale. Wine degree is at about 18 ��. Aperitif is also divided into aperitit and dessert wine by west: the wine that can stimulate appetite can be called aperitit. Aperitit characteristic not only can stimulate appetite, also have nourish, the effect such as strong, stomach invigorating, aperitit mainly contains Liquor, fermented milk, GET PEPPERMINT, all spends wine etc.; Dessert wine mainly refer to drink after the meal can digestive drinks, dessert wine comprises brandy, tequila, whisky, Liquor, fermented milk, GET PEPPERMINT, all spends wine etc. Remy Martin, No. one, celestial being etc. of wafing is that dessert wine typical case represents. In fact No. one, celestial being of wafing is that rum adds flavor confect and becomes, and other are such as banana wine, and almond wine, dried orange peel wine, coffee alcoholic cardial is all more common dessert wine.

Modern aperitif is allotment wine mostly, makes wine base with grape wine or ardent spirits, adds the soak of vegetable raw material or adds these raw materials when distilling. It is formulated that aperitif mainly has the root of appetizing effect plant, stem, leaf, medicinal material, spices etc. taking grape wine or liquor as raw material adds. Abroad add into star anise, root of Dahurain angelica root, bitter almond, lemon peel, coriandrum, absinth grass, peppermint, Holland's root, fennel, beautiful cassia bark etc.

China's traditional Chinese medicine has many effects very good appetizing promoting digestion plant amedica (1) (2). It represents recipe such as the lenitive pill of famous doctor's ZHU Dan-xi (1281-1358 in Christian era) " red small stream heart method " of: the Yuan Dynasty, by hawthorn (Jiao), Medicated Leaven (stir-fry), the tuber of pinellia (processing), Semen Raphani, Poria cocos, dried orange peel, the capsule of weeping forsythia form. Can help digestion, lead stagnant and stomach. Stagnating for dyspepsia, distension and fullness in the abdomen, rotten acid regurgitation, anorexia, curative effect is quite good, selects the DASHANZHA WAN that its main medicine is developed afterwards, is made up of hawthorn, Divine Comedy, Fructus Hordei Germinatus three taste medicine. Have help digestion, except long-pending, aid digestion function. The common feature of these two good recipes is except Medicated Leaven, outside the tuber of pinellia two taste, is all the common plant that also medicine is also eaten, and resource is enriched. We are according to this feature, are inheriting on forefathers' invaluable experience basis, and knot and modern study achievement, subtract the tuber of pinellia, Poria cocos, the capsule of weeping forsythia. Constituting by hawthorn, roasted malt, fry Semen Raphani, the new formula of the appetizing promoting digestion of the main raw materials such as dried orange peel, sweet fennel, Buddha's hand, sea-buckthorn, Radix Glycyrrhizae, cassia bark, for crowd maldigestion person. Owing to the party is monarch taking hawthorn, roasted malt, dried orange peel is minister, fries Semen Raphani for assistant, and sweet fennel, Buddha's hand, sea-buckthorn, Radix Glycyrrhizae, cassia bark are for making, and main function is that " appetizing " is aid digestion, therefore named life Fruit of Pashi Pear aperitif and beverage. Due to the difference of Chinese and Western culture, the look of Chinese tradition spirits culture emphasis wine, perfume (or spice), taste, although medicinal liquor is a lot of, but based on tonic, there is not yet special aperitif so far on market, this wine may be appetizing first wine of China.

In order to determine the creativeness of the present invention, we are domestic situation careful, that comprehensively retrieve patent family: Wu Xiujie, the health care tea liquor that a kind of promoting digestion absorbs and making method thereof. Application publication number: the weight part of its constitutive material of CN104327996A is: tribute chrysanthemum 40-50, food fibre 20-30, stir-fry Semen Raphani 4-6, Fructus Hordei Germinatus (parched to brown) 25-30, Poria cocos 3-5, orange peel 2-4, celery residue 4-6, guar gum 3-4, Fruit of Spiked Gingerlily 1-2, stem of Broadbean 2-4, Massa Medicata Fermentata (parched to brown) 3-5, Radix Ephedrae 1-2, wheat thorn rattan 1-2, phyllanthus emblica extracting solution 0.4-0.5, Fructus Mume extract 1-2, maltase 0.4-0.6, milk-acid bacteria 2-3, cereuisiae fermentum 1-2, composite nutrient 3-4, maltose 6-8; This health care tea liquor has taste flavor, nutritious, add the herbal medicine of multiple integration of drinking and medicinal herbs, contribute to stomach digestion, improve intestinal function, reduce gastrointestinal stimulation, the simultaneously wherein nutritive substance such as fiber-enriched matter, maltose, human body resistance to oxidation can be increased, improving health and skin health, to poor appetite, person has certain curative effect. But the party is numerous and diverse, Radix Ephedrae etc. can not enter drink by Ministry of Health's regulation. It is handsome that snow is thanked to by Hunan university of TCM, the health care tea bag of a kind of spleen benefiting and stimulating the appetite. Application publication number: CN104351436A. Material medicine: Daidaihua 5-10 part, fructus amomi 5-10 part, sea-buckthorn 10-20 part, hawthorn 10-20 part, roasted malt 10-20 part, Membrane of Chicken Gizzard 20-25 part, Semen Raphani 10-20 part, cleans above-mentioned raw materials medicine and is placed in the baking oven of 60-70 DEG C to dry; Medicine after drying is pulverized, crosses 80 order sieves; Medicine powder after sieving is packaged in tea bag bag. The health tea of the present invention wraps in the process drunk at ordinary times, plays spleen benefiting and stimulating the appetite, eliminates various eating accumulation, the effect that treatment children's appetite is not good; The health care tea bag of the spleen benefiting and stimulating the appetite of the present invention is tea bag bag, easy to carry, clean hygiene. But fructus amomi has pungent taste, Membrane of Chicken Gizzard is perishable should not cook drink, should technique fall behind. Applicant: a kind of JIANWEI XIAOSHI PIAN of Liu Shao Na and its preparation method application publication number: CN104288615A form: ginseng 10-16 part, hawthorn 10-20 part, Radix Glycyrrhizae 8-12 part, Membrane of Chicken Gizzard 8-10 part, six bent 12-18 part, Fructus Fici 8-12 part, Semen Raphani 10-16 part, Fructus Hordei Germinatus 10-20 part, Xylitol 10-16 part, honey 10-14 part, starch 30-50 part, water 50-70 parts; The JIANWEI XIAOSHI PIAN of the present invention, preparation method is simple, and product extraction yield height, can reduce production cost, it is possible to long-pendingization that disappear is stagnant, spleen benefiting and stimulating the appetite and stomach soothing the liver, genus health medicine trade, has vast potential for future development. But these product are difficult to by evaluation with medicine application, because like product is a lot of. A kind of stomach strengthening and digestion promoting tea granule of contriver: Zhang Huawei and its preparation method application publication number: CN104172164. Raw material is made: Poria cocos 4-5, sealwort 3-4, Membrane of Chicken Gizzard 5-6, Semen Raphani 3-4, dried orange peel 4.5-5, hair harvest root 1-2, shank ginseng 2-3, maltodextrin 10-15, hawthorn 20-22, pawpaw 10-12, Semen Coicis 6-7, milk powder 3-4, soda water 8-9, white sugar 4-5, mung bean 5-6, wild cabbage 7-8, rye flour 15-20, abalone kernel 4-5, shrimp powder 10-11, caraway 6-7, food vinegar 45-50, milk-acid bacteria 0.1-0.12, nutritional additive 10-11. The Chinese medicinal materials added in the tea granule of the present invention is after vinegar steams, the objectionable impuritiess such as the germ, pathogenic microorganism and the worm's ovum that are attached in medicinal material can be killed, also the property of medicine can be made gentleer, the collocation hawthorn such as Membrane of Chicken Gizzard wherein, dried orange peel can make the present invention have the effect of stomach strengthening and digestion promoting, in addition, each proportioning raw materials science in the present invention, unique flavor.But sealwort in formula, shank ginseng can not enter drink by Ministry of Health's regulation. contriver: Xie Xuejiao, Chinese medicine composition with strengthening spleen and nourishing stomach effect and its preparation method and application application publication number: CN104127758A. the effective constituent of described Chinese medicine composition is prepared from primarily of the raw material of following weight parts: Herba Dendrobii 2-40 part, Chinese yam 1-40 part, sea-buckthorn 2-40 part, hawthorn 2-40 part, roasted malt 2-40 part, Membrane of Chicken Gizzard 2-40 part, Semen Raphani 2-40 part. Chinese medicine composition of the present invention has significant strengthening spleen and nourishing stomach effect, and it can significantly improve the spleen-stomach diseases patient poor appetite, maldigestion and the vexed swollen symptom of chest and abdomen. but Membrane of Chicken Gizzard easily becomes shield. contriver: Hu Anran, a kind of stomach nourishing tea. application publication number: CN104095100A. selected hawthorn, dried orange peel, Fructus Hordei Germinatus, pawpaw, Fructus Fici, Radix Glycyrrhizae, matrimony vine, dark plum, Semen Myristicae, mulberries, Semen Raphani, almond, cape jasmine, Buddha's hand, the multiple integration of drinking and medicinal herbs food material of cloves, pulverize, with stainless steel pulverizer 40-80 order, techniques such as loading heat-sealing type tea filter paper bag and make alternative tea, have the unique advantage integrating dietotherapy, prevention, conditioning three efficacy. but cape jasmine, cloves tea making are bitter and pungent. contriver a: group of stars (medicine company) limited-liability company Jiang Li is beautiful for White Cloud Mountain, Guangzhou, the preparation method of valiant fighter's digestion promoting oral liquid. application publication number: CN104083617A. the present invention discloses the preparation method of a kind of valiant fighter's digestion promoting oral liquid, comprise the steps: get the Radix Astragali, Rhizoma Atractylodis Macrocephalae (parched), dried orange peel, the tuber of dwarf lilyturf, the root of large-flowered skullcap, stir-fry hawthorn and fry Semen Raphani, boiling, obtains extracting solution, it is filtered through supermicro filtration membrane, obtain clear liquid, again clear liquid is concentrated to clear cream, clear cream adds refining honey, potassium sorbate and purified water, mixed even, filter through tubular ultra-filtration membrane equipment. preparation method of the present invention determines the best approach and the top condition of preparation valiant fighter's digestion promoting oral liquid, the method first adopts supermicro filtration membrane effectively to be filtered by extracting solution, without the need to the refrigeration operation in traditional mode of production, by tubular ultra-filtration membrane filtering technique, the liquid after preparation is carried out end-filtration again, it significantly improves the content of baicalin in liquid clarity and liquid, improve product quality, also assures that the quality stability of product, also can realize producing without alcoholization, significantly shorten the production cycle, reduce energy consumption and production cost, it is suitable for large-scale production. but invention is medicine, non-beverage.

Though above patent application respectively has advantage, but our composition is after selected, and formula refining, technique is advanced.

We are from, State Food and Drug Administration's data query, queried the essential information through the protective foods of State Food and Drug Administration's examination & approval from 12 days December in 2003 after. The content list of " national OTC ", has 12209 records, wherein the content list of keyword " promoting digestion ", has 80 records, and the content list of keyword " hawthorn " has 10 records. Wherein as the like product of promoting digestion representational have several as follows: the good shellfish shellfish oral liquid of eastern good board that Jiangxi Li Jia pharmaceutcal corporation, Ltd produces, functional component/every 100ml of significant component content contains: total flavones 65.4mg, main raw material hawthorn, Fructus Hordei Germinatus, Semen Raphani, Poria cocos, Chinese yam, xanthan gum, Steviosides, water; This only promise oral liquid of correction board that biotechnology company limited produces is revised in Jilin, functional component/every 100ml of significant component content contains: dextrinosan 15g, zinc 10mg, iron 30mg, main raw material dextrinosan, Membrane of Chicken Gizzard, roasted malt, hawthorn, stir-fry Semen Raphani, Zinc Gluconate, Sytron, sucrose, deionized water, banana flavour; Pharmacy in river, Jiangxi (group) limited liability company, name of product: board food power beverage in river, composition/every 100ml of significant component content contains: total flavones (in rutin) 2.17mg, main raw material hawthorn, Fructus Hordei Germinatus, Chinese yam, dried orange peel, Sodium Cyclamate, sucrose, Citric Acid, potassium sorbate, strawberry flavour, distilled water, eating method and amount every day 3 times, each 50ml; Shake even time edible, edible after meal. Product specification 50ml/ bottle, 150ml/ bottle, 300ml/ bottle; The promoting digestion and removing indigestion oral liquid of Nanchang Chuan Qi healthcare products company limited, main raw material hawthorn, Membrane of Chicken Gizzard, White Hyacinth Bean, Poria cocos, Zinc Gluconate, thiamine hydrochloride, taurine, sucrose, deionized water; The huge day board stomach invigorating digestion oral liquid that Jiangxi Ju Bioisystech Co., Ltd produces, functional component/every 100ml of significant component content contains: total flavones (in rutin) 101mg; Main raw material Fructus Crataegi, Fructus Hordei Germinatus, the bighead atractylodes rhizome, Poria cocos, White Hyacinth Bean, Membrane of Chicken Gizzard, Semen Raphani, sucrose. Above product suitable population is maldigestion person, be not suitable for crowd without.

We are from the content list of State Food and Drug Administration's data query national OTC keyword " Fruit of Pashi Pear ", have 0 record, the content list of domestic medicine " keyword " " Fruit of Pashi Pear ", have 0 record, none repeats to show this name of product and existing medicine and healthcare products, its formula composition also with ancient prescription and existing medicine and protective foods completely without repeating and duplicate.

Summary of the invention

The object of the present invention: one is to provide the aid digestion a kind of plant liquor of more effective appetizing and beverage; Two are to provide the preparation method of this wine and beverage.

1. formula and consumption

The formula of the present invention and consumption are according to pertinent literature and application practice, determine through repeated screening, and each composition consumption could obtain good effects in following weight scope:

Hawthorn 20-70 part, roasted malt 7-20 part, dried orange peel 5-15, stir-fry Semen Raphani 10-30, sweet fennel 5-10, Buddha's hand 5-10, sea-buckthorn 10-20, Radix Glycyrrhizae 6-12, cassia bark 5-10, xylo-oligosaccharide 2-10 part, potassium sorbate 0.3-0.6 part.

It is preferably hawthorn 50 parts, roasted malt 15 parts, dried orange peel 10 parts, fries Semen Raphani 20 parts, sweet fennel 8 parts, Buddha's hand 8 parts, sea-buckthorn 15 parts, 8 parts, Radix Glycyrrhizae, 8 parts, cassia bark, xylo-oligosaccharide 5 parts, potassium sorbate 0.5 part.

Further, the formula of the present invention also comprises Fructus Sinopodophylli 2-8 part, it is preferable to 5 parts.

Further, the formula of the present invention also comprises stem of noble dendrobium 2-8 part, it is preferable to 3 parts.

Dosage is less than this scope, and then effect is poor, look light deficient pool, and dosage is greater than this scope then easily containing throw out, and look heavy is muddy, and mouthfeel is poor.

The dry mature fruit of hawthorn rosaceous plant Fruit of Pashi Pear CrataeguspinnatifidaBge.var.majorN.E.Br. or hawthorn CrataeguspinnatifidaBge.. Crategolic acid is sweet, tepor. Enter spleen, stomach, Liver Channel. Function strengthening the spleen and stomach, aid digestion, be disappear carnivorous stagnant top grade, be widely used in maldigestion etc., therefore select as monarch, therefore its consumption accounts for large percentage in formula; Research shows: hawthorn is containing Fructus Crataegi flavone and multiple organic acid, and containing lipolytic enzyme, after entering stomach, can strengthen the effect of enzyme, promotes carnivorous digestion, contributes to cholesterol to transform. Hawthorn is nutritious, and all nutritive ingredients, particularly organic acid and the ascorbic content that almost contain fruit are higher. Hawthorn sweet and sour taste, is applicable to eating raw, is applicable to again being processed into protective foods. Modern medicine study proves: hawthorn still has step-down, falls fat, increases effect (3) (4) of coronary flow and arrhythmia etc.

Fructus Hordei Germinatus is that drying becomes through germinateing for the mature fruit of Gramineae annual herb plant barley HordeumvuigareL.. Nature and flavor: sweet are flat. Gui Jing: taste. Compendium of Materia Medica " say: " can digest all rice, face, all pulp dyspepsias " is promoting digestion and removing indigestion key medicine. It is applied to dyspepsia not disappear, poor appetite etc.; Composition mainly contains ��-and beta-amylase (amylase), katalaze enzyme (catalyticase), peroxidation isomerase (peroxidisomerase) etc. Amylose complete hydrolysis can be become maltose by ��-amylase, and ��-amylase then makes it to resolve into short straight key polyglucose (i.e. dextrin), and the latter can again for ��-amylase be hydrolyzed into maltose. Therefore starch is decomposed into maltose and dextrin under the effect of �� and ��-amylase. Except Fructus Hordei Germinatus itself can except promoting digestion, the secretion of hydrochloric acid in gastric juice and stomach en-is also had slight promoter action (5) by Fructus Hordei Germinatus decoction.

Dried orange peel is the dry mature skin of rutaceae orange CitrusreticulataBlanco and cultivated variety thereof. Dried orange peel taste is arduous, warm in nature, has warm stomach and falls apart effect cold, strong spleen of regulating the flow of vital energy, and the people being applicable to the symptoms such as stomach swollen full, maldigestion, poor appetite is edible. Modern study shows, containing the composition such as a large amount of volatile oil, hesperidine, vitamins B, C in dried orange peel, gi tract are had gentle hormesis by the volatile oil contained by it, can the secretion of promoting digestion liquid, get rid of enteron aisle inner product gas, increase appetite. Gi tract are had gentle hormesis by the volatile oil contained by it, can the secretion of promoting digestion liquid, get rid of intestinal tube inner product gas, increase appetite. The bitter substance of dried orange peel is taking limonin and bitter principle as representative " limonoid ", and this kind of limonoid taste is gentle, soluble in water, contributes to the digestion of food. When dried orange peel is used for cooking dishes. Its bitter taste and other tastes are in harmonious proportion mutually, can form original in style local flavor. Pipe smooth muscle is played dual regulation by dried orange peel. The composition Hesperidin that dried orange peel had both moved containing excited stomach, has the effect strengthening gastric motility, and energy whetting appetite, de-swelling of regulating the flow of vital energy; Again containing the composition volatile oil of relaxing smooth muscle, the spasmic pain of stomach thus can be released. Be the common medicine for the treatment of maldigestion, especially stomach do not relaxed, poor appetite, vexed swollen, pain, feel sick, symptom for telling is more suitable general, plays relieving the gastric disorder and regulating vital energy, effect that de-swelling is alleviated pain, therefore elect as and make medicine (6).

The Semen Raphani that Semen Raphani is commonly called as. It is the dry mature seed Chemical Composition of cress radish (RaphanussativusL): seed is containing sinapic acid choline ester (sinapine) and fatty oil 30%, containing a large amount of erucic acid (erucicacid) and linolic acid (linoleicacid) in oil, linolenic acid (linolenicacid), also removes hydrogen campesterol (22-dehydrocampesterol) containing brassicasterol (brassicasterol) and 22-. Another containing radish element (raphanin). Semen Raphani nature and flavor, pungent, sweet, flat. Return lung, spleen, stomach warp. Compendium of Material Medica is recorded, functions such as " lower gas Dingchuan, control phlegm, and help digestion de-swelling, profit stool and urine " that frying Semen Raphani has. For controlling retention of food and drink, abdominal distention, constipation, therefore select as assistant; Experiment display: experimental mouse stomach row is just had remarkable promoter action by the different extract of Semen Raphani with Intestinal pushing, mice with constipation is all had defecating feces excretion by Semen Raphani oil, Semen Raphani the water extracted immersing paste, a large amount of clinical report is fried Semen Raphani Therapeutic diet and is stagnated, abdominal distention, constipation truly has good effect, and indigestion symptom can be made obviously to improve, therefore think that Semen Raphani " promote qi circulation digestion promoting " acts on, essence to promote gastrointestinal motility. In addition, still there is the effect of resisting pathogenic microbes, detoxification and hypotensive effect, therefore it is selected into as assistant (7).

Sweet fennel taste is pungent, warm in nature. Return liver, kidney, spleen, stomach warp. Function dispersing cold for relieving pain, regulates the flow of vital energy and stomach, is the common food for the treatment of maldigestion.

Buddha's hand whole body is all precious. Root, stem, leaf, flower, fruit all can be used as medicine, pungent, bitter, sweet, warm, nontoxic; Enter liver, spleen, stomach three warp, have activating QI to eliminate phlegm, only vomit the multiple medicinal functions such as dissipate-swelling, liver soothing and the spleen invigorating and stomach. To the maldigestion of common people, that chest and abdomen are swollen is vexed, has more significant curative effect. Clothes have the effect of health-care for a long time. Experimentation on animals shows: rat, rabbits infestines are had obvious restraining effect by this product alcohol extract, and anesthetized cat, rabbit are also had same restraining effect at body intestinal tube by intravenous administration. The rabbit duodenum spasm caused by vagusstoff has remarkable spasmolysis.

Sea-buckthorn sea-buckthorn is economic plants, and product can eat, again can be medicinal. Fruit and oil have very high pharmaceutical use, can treat gastric duodenal ulcer and maldigestion etc., and the illnesss such as chronic superficial gastritis, atrophic gastritis, colitis is evident in efficacy; Can reducing cholesterol, allevating angina pectoris shows effect, and prevents and treats the effect of coronary atherosclerotic heart disease in addition.

Radix Glycyrrhizae taste is sweet, and property is gentle, enters the heart, spleen, lung, stomach four warp. Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription. It is usually used in weakness of the spleen and the stomach, fatigue and weakness. Radix Glycyrrhizae has similar adrenocortical hormone sample effect. The gastric acid secretion caused by histamine too much has restraining effect; And have antiacid and alleviate gastrointestinal smooth muscle spasm effect. Remove flavonoid glycoside class in the medicinal extract of glycyrrhizin and Radix Glycyrrhizae and rat experiment ulcer is had obvious provide protection. In addition, Radix Glycyrrhizae is also good at the mediation property of medicine, separates the poison of hundred medicines.

Cassia bark taste is pungent sweet, hot in nature, enters kidney, spleen, bladder through having benefit Yuanyang, warming the spleen and stomach, removing accumulated cold, and effect of coronary circulation-promoting pain-relieving and antidiarrheal is used for the stomachache with cool feeling of insufficiency of spleen-YANG, and abdominal pain diarrhea,

Xylo-oligosaccharide has another name called wood oligose, is taking refining corncob powder as raw material, through a kind of functional sugar that the production technique such as the separation of enzyme method, purification process, is a kind of sweeting agent with special role. Xylo-oligosaccharide is the functional polymerization sugar being combined into ��-1,4 glycosidic link by 2-7 wood sugar molecule. Having unique advantage compared with the soybean oligosaccharide used with usual people, oligofructose, oligomeric isomaltose etc., it can optionally promote the proliferation activity of intestinal bifidobacteria. Its bifidobacterium factor functional is 10-20 times of other polymerization carbohydrate. Xylo-oligosaccharide breeds one of the strongest kind of bifidus bacillus function in polymerization carbohydrate, its effect is nearly 20 times of other polymerization carbohydrates, the enzyme of xylo-oligosaccharide it is not hydrolyzed in human gastrointestinal tract, so it can directly enter and be preferably bifidus bacillus in large intestine and utilized, promote that bifidus bacillus propagation produces multiple organic acid simultaneously. Reduce enteron aisle PH value, suppress harmful bacteria growth, probiotic bacterium is bred in a large number at enteron aisle, pathogenic bacteria is had stronger adsorptive power by xylo-oligosaccharide, as intestinal bacteria, enteritis Men Shi bacterium, Klebsiella pneumonia, Aeromonas hydrophila etc. can be adsorbed onto on xylo-oligosaccharide, owing to xylo-oligosaccharide is not degraded by the digestive ferment in enteron aisle, the pathogenic bacteria that can carry attachment is excreted by enteron aisle, thus prevent disease cluster in enteron aisle, reach the object preventing diarrhoea. Bifidus bacillus utilizes xylo-oligosaccharide, produces a large amount of short chain fatty acids, can stimulate intestines peristalsis, promotes digestive tract power, increases ight soil wettability, and keeps certain osmotic pressure, thus prevents constipation. Protection liver function, reduces serum cholesterol, reduces blood pressure, energy enhancing body immunizing power, anticancer, impels body to generate multiple nutrients material, comprises health-care effect (8) (9) such as vitamins B, nicotinic acid and folic acid.

Potassium sorbate is that it can rapid decomposition be carbonic acid gas and water to a kind of unsaturated fatty acids (salt), noresidue in body by the metabolic system absorption of human body. Can mould fungus inhibition effectively, the activity of yeast and aerobic bacterium, the harmful microbe Growth and reproductions such as Clostridium botulinum, staphylococcus, Salmonellas can also be prevented, but the beneficial microorganisms such as anaerobism sporeformer and Lactobacterium acidophilum is almost invalid, it is stronger than germicidal action that it restrains the effect grown, thus reach the shelf time effectively extending food, and keep the local flavor of original food. For the industry such as food, beverage, beverage consumption 0.5g/kg, its preservative effect is 5-10 times of like product Sodium Benzoate. Sorbic Acid is the antisepsis antistaling agent of the highly effective and safe of international food and agricultural organization and Health Organisation recommendations, therefore this formula selects it to be sanitas.

Feature of the present invention is the look of root Ju wine and beverage, fragrant, and taste requirement is painted with look gorgeous hawthorn at prime; The natural tart flavour of hawthorn, the fragrance of roasted malt, has put forward drink quality. After increasing the xylo-oligosaccharide of appropriate amount so that it is sour-sweet tasty and refreshing, red gorgeous tempting, obtain and whet the appetite at a glance, drink two excellent effect that mouthfeel is good. Therefore, selected in formula supplementary material makes product can reach expection appetizing function.

Above composition joins use, and relation is clearly demarcated, reasonable recipe, and effect of collaborative generation is safe and reliable, has digesting and appetizing, improves stomach and intestine, the function of promoting digestion. Originally the middle product without incompatibility are joined, to human body safety.

2. preparation method of the present invention

2.1 crude drugs arrange to be concocted:

2.1.1 hawthorn, roasted malt, dried orange peel, stir-fry Semen Raphani, sweet fennel, Buddha's hand, sea-buckthorn, Radix Glycyrrhizae, cassia bark, all meet the Pharmacopoeia of the People's Republic of China 2010 editions one regulation. Meet " new resource food list and be food and drug list " that the Ministry of Health announces.

2.1.2 xylo-oligosaccharide meets QB/T2984-2008 regulation, and potassium sorbate meets GB13736-2008 regulation.

2.2 extract:

According to Fruit of Pashi Pear appetizing formula ratio, take hawthorn, roasted malt, dried orange peel, stir-fry Semen Raphani, sweet fennel, Buddha's hand, sea-buckthorn, Radix Glycyrrhizae, cassia bark, the times amount water that adds 10, it is heated to 70 DEG C, Shenzhen's remittance hundred million is adopted to reach the immerseable KESP-100KH ultrasonic extraction device of mechanical & electronic equipment corporation, Ltd's production, extract 3 times, extract about 50min every time; Filter, merging filtrate.

2.3 concentrate:

It is 1.20-1.30, pH3.0-4.0 that merging filtrate is evaporated to relative density, obtains concentrated solution, is contained by concentrated solution in clean all turning barrels, indicates name of product, lot identification mark, specification, quantity, operator's name, for subsequent use.

2.4 batchings:

Add xylo-oligosaccharide, potassium sorbate by formula for a product respectively by above-mentioned concentrated solution, drop in V-type mixing tank, add 16 times of 38 degree of white wine or grape wine afterwards again, mix and blend 10min, it is ensured that evenly. Leave standstill 24 hours precipitations, get supernatant liquor and put into filling machine. Filling in glass wine bottle, every bottle of 250ml.

The originality of 2.5 techniques

It is that we with reference to many research documents for standby technique processed of the present invention, and carries out after preferably, just determine following technique: ultrasonic wave extraction is the means of a kind of up-to-date comparatively maturation being applied to herbal medicine effective ingredient extraction and isolation in recent years. The leaching that its principle mainly utilizes ultrasonic wave cavatition in a liquid to accelerate active ingredients of plants is extracted. In addition, also utilizing next effect, such as mechanical vibration, diffusion, hits broken etc. so that it is accelerate to be extracted the diffusion of composition, release. Ultrasonic wave is very high 65--70 DEG C of working efficiency according to statistics. And the effective ingredient of temperature Chinese herbal medicine in 70 DEG C of degree is not damaged substantially. About 50 minutes (under 70 degree of conditions) active ingredients of plants extraction times. And the cooking time of cooking process often needs two to three hours. It it is more than the 3 times times of ultrasonic extraction time. Every tank extracts 3 times, substantially can extract more than the 90% of effective ingredient.

The method of tradition medicinal liquor preparation is a lot of, and having of generally commonly using at present is several as follows:

2.5.1 cold-maceration: by the Chinese medicinal materials thin slice after the process of preparing Chinese medicine or coarse crushing particle, the container being placed in sealing adds appropriate soaking in Chinese liquor about 7-14 days, after treating that effective constituent is dissolved in wine, can filter out liquid and drink. But this method can not extract effective constituent completely, and time-consuming take material.

2.5.2. hot dipping method: hot dipping method is a kind of ancient and effectively make the method for medicinal liquor. Normally boil certain time by same to Chinese medicinal materials and wine, then let cool storage. This method can accelerate leaching speed, and the effective constituent in Chinese medicinal materials can be made again more easily to leach. But when boiling wine, should prevent alcohol from burning, prevent alcohol from volatilizing again. Therefore now use less.

2.5.3. decocting method: Chinese medicinal materials must be pulverized into powder by this method, all puts into marmite, adds water to out powder about 10 centimetres, soaking about 6 hours, then heated and boiled 12 hours, after filtration, the dregs of a decoction add water appropriate pan-fried 1 time again again, merge twice liquid, leave standstill after 8 hours, get supernatant liquor heating again and it is condensed into tune paste, after cooling, then add appropriate wine, mixed even, it is placed in container, after about 7 days, gets supernatant liquor. But the aromaticity Chinese medicinal materials containing volatile oil should not adopt this method.

2.5.4. make wine method: first Chinese medicinal materials is added water and decoct, after filter and remove residue, be condensed into concoction, be placed in clean container, add lid sealing, put insulation place about 10 days, reduce the contact with air as far as possible, and keep certain temperature, filter residue after fermentation. But this method is time-consuming perishable again.

2.5.5. percolation: percolation is applicable to pharmaceutical factory and produces. Chinese medicinal materials first being pulverized into thick end, adds appropriate white wine and infiltrate 24 hours, medicinal material coarse powder is fully expanded, gradation evenly loads bottom and is lined with oozing of absorbent cotton and filters in device, every time dress good after compress with wooden stick. Install Chinese medicinal materials, gauze in upper cover, and press the little stone that last layer is cleaned; In order to avoid making medicinal powder float after adding white wine. Then the switch of mouth under percolator is opened, add white wine from oozing device top of filtering again slowly, close when liquid flows out from lower mouth and close switch, thus the liquid making outflow is poured into ooze and is filtered in device, continue to add white wine to exceeding medicinal powder face number centimetre, then add lid, place and after 24-48 hour, open lower mouth switch, percolate is slowly flowed out. Collect, by specified amount, liquid of filtering, add correctives and stir even, seal after dissolving, filter out liquid after leaving standstill a few days, then add white wine to specified amount, obtain medicinal liquor. Still waste time and energy, effective constituent can not be extracted completely.

This product, according to existing more advanced, ripe ultrasonic extraction process (10) (11) (12), adopts supersound extraction effective ingredients in plant, simmer down to medicinal extract, then adds wine or the water of proportional quantity, and mixing hooks being wine or beverage. there is method simplicity, laborsaving province material, energy-conserving and environment-protective, more than 95% effective constituent can be extracted, it is convenient to transport, only need medicinal extract is transported to somewhere, add water with wine in locality, greatly reduce production cost, and the local flavor that can ensure wine and beverage is constant, ensure quality product, the production technique of the method plant liquor at home belong to pioneering, we announce in announcement systems at State Intellectual Property Office's patent Chinese patent and have retrieved as carrying taking " supersound extraction effective ingredients in plant hooks white spirit process ", result is: " not having the content of this respect ", display there is no the patent of this method at present.

Technical knowhow: Semen Raphani frying technology is ensure that the pass of Semen Raphani effect is good for always, and raw Semen Raphani is just irritant to stomach as eaten raw turnip, and the noisy discomfort of stomach can be caused even to vomit. The concocting method of<<Chinese Pharmacopoeia>>: a, Semen Raphani: get crude drug, removes impurity, cleans, dry. Used time smashs to pieces. B, stir-fry Semen Raphani: get clean Semen Raphani, put in preheating frying container, with slow fire heating, fry to heaving, have cracker, and appearance color and luster is deepened, inner yellow, and when having fragrance to overflow, taking-up is dried in the air cool. Used time smashs to pieces. But how to fry and just can reach that big to produce ideal effect be gordian technique. Semen Raphani because of its seed tiny, Semen Vaccariae can not being resembled during stir-fry can snuff, change without significant color and luster, slightly careless with regard to coking, the duration and degree of heating is selected very important for this reason. Old pharmaceutical worker fries with low baking temperature slowly according to repeatedly groping, and the time is extended down to ten five to two ten minutes, and Semen Raphani sends cracker, and overflows warmth odor, goes out pot and spreads out. Now seed coat is micro-splits, and the seed coat of rice-pudding redness is covered with tiny grey point, plants benevolence not burnt, to obtain final product. But<<Chinese Pharmacopoeia>>and old pharmaceutical worker's experience entirely be experience, it does not have quantizating index, it is very difficult to run in the industrial production. We are through the microwave oven frying method of research repeatedly: microwave big fire, heating 3.5min. Can reaching and heave, have cracker, appearance color and luster is deepened, inner yellow, and has fragrance effusion ideal effect. Pulverizing as last stomach of taking is very comfortable, smell fragrant, entrance is micro-peppery very fragrant. This technology solves fries Semen Raphani technical barrier for many years, creative.

For preferred better technique, we take total flavones as index, the measuring method of total flavones in protective foods in " protective foods inspection and assessment technical specifications " (2003) published according to Ministry of Health's health legal system and supervision department, following 6 batch sample having carried out Different Extraction Method respectively to the comparative study of general flavone content, result is as follows:

Different Extraction Method is to the comparative study of general flavone content

Lot number	The name of an article	General flavone content in every 100ml
			2013X0287	The ultrasonic alcohol extract of compound Fruit of Pashi Pear	184.0mg/100ml
2013X0290	The ultrasonic Aqueous extracts of compound Fruit of Pashi Pear	182.5mg/100ml
			2013X0291	Compound Fruit of Pashi Pear water cooking liquid	14.2mg/100ml
2013X0288	Single ultrasonic alcohol extract of taste hawthorn	27.8mg/100ml 7 -->
			2013X0289	Single ultrasonic Aqueous extracts of taste hawthorn	25.4mg/100ml
2013X0292	Single taste hawthorn water cooking liquid	1.0mg/100ml

Above result shows: general flavone content 184.0mg in the every 100ml of the ultrasonic alcohol extract of Fruit of Pashi Pear alcohol, general flavone content 182.5mg in the every 100ml of the ultrasonic Aqueous extracts of Fruit of Pashi Pear, but both statistics no significant differences, Fruit of Pashi Pear water cooking liquid is only 14.2mg, has notable difference with supersound extraction.

Single ultrasonic alcohol extract 27.8mg of taste hawthorn, single ultrasonic Aqueous extracts 25.4mg of taste hawthorn, both statistics no significant differences, single taste hawthorn water cooking liquid is only 1.0mg, has notable difference with supersound extraction. Illustrate that supersound extraction is obviously better than traditional water decoction method, in view of ultrasonic water extraction cost is low, therefore select ultrasonic water extraction for this production technique.

Embodiment

Below in conjunction with specific embodiment, set forth the present invention further. Limit the scope of the invention it will be understood that these embodiments are only not used in for illustration of the present invention. The experimental technique of unreceipted concrete condition in the following example, usually conveniently condition or the condition advised according to manufacturer. Unless otherwise indicated, otherwise all percentage ratio, ratio, ratio or part number be weight.

Unless otherwise defined, the same meaning that in literary composition, all specialties of using and science term and one skilled in the art are familiar with. In addition, any method similar or impartial to described content and material all can be applicable in the inventive method. Literary composition described in better implementation method and what material only was used as to demonstrate.

Fruit of Pashi Pear appetizing concentrated solution promoting digestion function experimentation on animals report (selected parts)

1. test materials

1.1 tested materials: Fruit of Pashi Pear concentrated solution (is called for short: appetizing drink) 310ml/ bottle, and every 1000ml is total to 100g by hawthorn, roasted malt, stir-fry Semen Raphani, dried orange peel etc. and forms, and nourishing function is promoting digestion (for maldigestion). Population dose 310ml/ bottle, 2 times/day, amounts to 62g raw material by 1 bottle/time. Adult is calculated as 1.03g raw material/kg body weight by 60kg body weight.

Censorship sample 1.5L closed plastic box is packed, content is the concentrated thick liquid of brown, and No. 1 side is 7.53g raw material/g, No. 2 sides is 9.12g raw material/g, product batch number (generation date of application) 20131115, there is provided by Hu Baihu, 4 DEG C, this laboratory stored refrigerated.

When adopting mouse test, directly extract concentrated solution respectively adding distil water be diluted to 1.55g raw material/ml and be used for high dose group, get high dose group 4ml adding distil water 8ml and it is diluted to 0.52g raw material/ml for middle dosage group, get middle dosage group 4ml adding distil water 4ml be diluted to 0.26g raw material/ml be used for low dose group, gavage (ig) volume 0.2ml/10gBW.

When adopting rat test, directly extract concentrated solution respectively adding distil water be diluted to 3.1g raw material/ml and be used for high dose group, get high dose group 20ml adding distil water 40ml and it is diluted to 1.0g raw material/ml for middle dosage group, get middle dosage group 15ml adding distil water 15ml be diluted to 0.5g raw material/ml be used for low dose group, ig volume 1.0ml/100gBW.

1.2 model agent: R-1132, every sheet content 2.5mg, lot number 201102014.

1.3 chemical reagent preparations: prepared Chinese ink is stuck with paste; 0.05mol/L hydrochloric acid soln; 2cm egg white glass capillary; Ether, physiological saline, iodine volt, 75% ethanol.

1.4 animals: SPF level SD kind female rats 56, body weight 130��150g; KM kind female mice 80, body weight 20��22g, examining and determine research institute's Laboratory Animal Resource center by Chinese food medicine provides, animal productiong credit number: SCXK (capital) 2009-0017. Large and small mouse sub-cage rearing, 4, every cage or 10, every treated animal 8 or 10, breeding observing after 7 days or 3 days for test.

1.5 laboratory animal room: be barrier environment, fully-closed state, three-stage filtration is blown, temperature 22��24 DEG C, relative humidity 40��45%, fluorescent lamp 12 hr light, laboratory animal occupancy permit number: SYXK (capital) 2011-0008. Autoclaving wood wool bits are bedding and padding. Plastics mouse box volume 35 �� 30 �� 17cm (rat) or 28 �� 17 �� 12cm (mouse), Stainless Steel Wire top cover. SPF level big and small mouse upgrowth breeding feed by Beijing Australia of section pull together feed corporation,Ltd produce, fodder production enterprise examination conformity certification number: capital raises careful (2009) 06166, product batch number: 13103123. Laboratory animal room of the court provides purified water freely to drink.

1.6 main Apparatus and instruments: 1/10 animal electronic balance is measured in sense, and 1/1000 electronic balance is measured in sense, 37 DEG C of constant incubators, electric furnace, anesthesia tank, timing register, vernier callipers, 1m Straight Steel Ruler, little emery wheel, sheet glass, diameter 0.8��1.0mm glass capillary, 100ml mortar, 50ml beaker, 25ml Tissue Culture Flask 60,1ml, 5ml, 10ml disposable syringe, large and small mouse dissects plate, sew up silk thread, mosquito forceps, medical scissors and tweezers etc.

2. method and result

The mensuration of 2.1 rat body weights and food ration

Test is divided into 7 groups (solvent control group, appetizing drink No. 1 square 30.9g/kg group, 10.3g/kg group and 5.2g/kg group, appetizing drink No. 2 square 30.9g/kg groups, 10.3g/kg group and 5.2g/kg groups), often organizes 8 rats. Every day ig1 time, continuous 30 days, after giving tested material, rat had no just rare or does just, without Systemic reaction. Each group every rat is weighed weekly 2 times, and every cage rat claims weekly feed total amount and residual content 2 times. Calculating each time period often organizes the mean body weight of rat, body weight increased value, food ration and food utilization. The results detailed in Table 1��4.

Table 1 whets the appetite drink to the observation of rat each week body weight

Note: compare p with solvent control group > 0.05.

Table 2 whets the appetite drink to the observation of rat each week body weight increased value

Note: compare p with solvent control group > 0.05.

Table 3 whets the appetite drink to the observation of rat each week food ration

Note: compare p with solvent control group > 0.05.

Table 4 whets the appetite drink to the observation of rat each week food utilization

Note: compare p with solvent control group > 0.05.

Result shows: appetizing drink No. 1 side and No. 2 each dosage groups in side are during giving tested material, rat body weight, body weight increased value, food ration and food utilization are had no obvious increase, comparing with solvent control group, statistical analysis has no significant difference (p < 0.05).

The mensuration of 2.2 rat gastric juice and proteolytic enzyme

Test is divided into 7 groups (solvent control group, appetizing drink No. 1 square 30.9g/kg group, 10.3g/kg group and 5.2g/kg group, appetizing drink No. 2 square 30.9g/kg groups, 10.3g/kg group and 5.2g/kg groups), often organizes 8 rats. Every day ig1 time, continuous 30 days, after giving tested material, rat had no just rare or does just, without Systemic reaction. 30th day ig gives fasting 24 hours after tested material, fasting 20 hours again ig give tested material or distilled water once. Etherization rat after 4 hours, surgical incision stomach wall, sews up silk thread ligation pylorus (closing the passage that gastric content is descending) at stomach and duodenum place, sews up incision of abdominal wall. After 5 hours, de-cervical vertebra puts to death rat, opens abdominal cavity, and mosquito forceps clamps esophagus hypomere orifice of the stomach place, and complete cutting gets full stomach, and is all taken out by gastric content, measures the gastric secretion total amount of every rat, calculates gastric juice output per hour. Getting 1ml supernatant gastric juice, to add 15ml0.05mol/L hydrochloric acid soln more mixed even in 25ml Tissue Culture Flask, put into 2 radicin pipes of fresh preparation, close bottleneck, put in 37 DEG C of constant incubators and hatch 24 hours, take out protein pipe, by the length of each protein pipe two ends transparent part of vernier caliper measurement, calculate pepsin activity and stomach en-output with the mean value of the 4 transparent length of end. Formula is as follows:

Pepsin activity (u/ml)=(mean values of four end protein pipe transparent part length)²��16

Stomach en-output (u/h)=pepsin activity �� gastric juice amount per hour

The results detailed in Table 5,6.

Table 5 whets the appetite drink to the observation of rat gastric secretion

Note: compare * P < 0.05 with solvent control group; * P < 0.01.

Table 6 whets the appetite drink to the impact of rat stomach proteolytic enzyme

Note: compare * P < 0.05 with solvent control group; * P < 0.01.

Result shows: gastric juice total amount, gastric juice output and stomach en-output are significantly increased by appetizing drink No. 1 square high dose group, and stomach en-output is significantly increased by middle dosage group; Gastric juice total amount, gastric juice output, pepsin activity and stomach en-output are significantly increased by appetizing drink No. 2 square high dose group, and stomach en-output is significantly increased by middle dosage group; Above numerical value compares with solvent control group, and statistical analysis has significant difference or significant differences (p < 0.05 or < 0.01).

2.3 mouse small intestine sporting trials

Test is divided into 8 groups (solvent control group, model control group, appetizing drink No. 1 square 30.9g/kg group, 10.3g/kg group and 5.2g/kg group, appetizing drink No. 2 square 30.9g/kg groups, 10.4g/kg group and 5.2g/kg group), often organizes 10 mouse. Every day ig1 time, continuous 15 days, after giving tested material, mouse had no just rare or does just, and without Systemic reaction, each group mouse body weight increases substantially normal. Within 15th day, again give tested material to each dosage group in fasting after 16 hours, give isopyknic distilled water to solvent control group and model control group; After 30 minutes except solvent control group, every mouse ig gives model agent compound diphenoxylate 5mg/kg (suitable people consumption 20X), gives model agent after 30 minutes, and each group gives prepared Chinese ink and stick with paste 0.6ml/ body weight; After 25 minutes, de-cervical vertebra puts to death mouse, cut open the belly separation abdominal viscera, cut and take whole gastrointestinal tissue, and carefully mesostenium is cut off, small intestine is slowly stretched, on the sheet glass spilling physiological saline, stretch small intestine, after retraction naturally, measure from pylorus��prepared Chinese ink stick with paste forward position distance (prepared Chinese ink is stuck with paste and advanced length) and from the initial distance (total small intestinal length) of pylorus��colon, calculate prepared Chinese ink and stick with paste propelling rate and prepared Chinese ink is stuck with paste and advanced conversion valueFormula is as follows:

Prepared Chinese ink is stuck with paste propelling rate (%)=prepared Chinese ink and is stuck with paste propelling length (cm) �� total small intestinal length (cm) �� 100%. The results detailed in Table 7.

Table 7 whets the appetite drink to the observation of mouse small intestine motion effect

Note: compare #p < 0.05 with solvent control group; * p < 0.05 is compared with model control group.

Result shows: the small intestine prepared Chinese ink of model control group and each dosage group of tested material is stuck with paste propelling rate and obviously slowed down; Comparing with solvent control group, statistical analysis all has significant difference (p<0.05). It is not obvious that the small intestine push speed of appetizing drink No. 1 side and No. 2 side's dosage groups low, middle compares change with model control group, no difference of science of statistics (p>0.05); The small intestine ink progradation of appetizing drink No. 1 side and No. 2 square high dose group and prepared Chinese ink advance conversion value to be then significantly increased, and compare with model control group, and statistical analysis has significant difference (p<0.05).

3. conclusion

Give appetizing drink No. 1 side and No. 2 sides 15 days or 30 days by KM kind mouse and the continuous gavage of SD kind rat, to rat each week body weight, body weight increased value, food ration and food utilization have no considerable change. Gastric juice total amount, gastric juice output and stomach en-output tool are had significantly increasing action by No. 1 square 30.9g/kg high dose group, and the slow model of mouse gastrointestinal peristalsis has obvious small intestine push speed increasing action; In 10.3g/kg, stomach en-output is had significantly increasing action by dosage group. Gastric juice total amount, gastric juice output, pepsin activity and stomach en-output are had significantly increasing action by No. 2 square 30.9g/kg high dose group, and the slow model of mouse gastrointestinal peristalsis has obvious small intestine push speed increasing action; In 10.3g/kg, stomach en-output is had significantly increasing action by dosage group.

Prompting: rat can be increased gastric secretion and stomach en-discharge at 30.9g/kg dosage by appetizing drink No. 1 side and No. 2 sides, alleviates and alleviates the mouse gastrointestinal peristalsis caused by compound diphenoxylate model agent slowly, thus has the effect of promoting digestion function. Appetizing drink No. 1 side and No. 2 every experimental datas in side compare and have no notable difference.

Acute toxicity test report (selected parts) of Fruit of Pashi Pear appetizing drink (concentrated solution)

1. test materials

1.1 tested materials: the red appetizing drink of mountain wheat (is called for short: appetizing drink) 310ml/ bottle, and every 1000ml is containing the 100g composition altogether such as hawthorn, roasted malt, stir-fry Semen Raphani, dried orange peel, and nourishing function is promoting digestion (for maldigestion). Population dose 310ml/ bottle, 2 times/day, amounts to 62g raw material by 1 bottle/time. Adult is calculated as 1.03g raw material/kg body weight by 60kg body weight.

Tested material 1.5L closed plastic box is packed, content is the concentrated thick liquid of brown, and No. 1 side is 7.53g raw material/g, No. 2 sides is 9.12g raw material/g, product batch number (generation date of application) 20131115, there is provided by Hu Baihu, 4 DEG C, this laboratory stored refrigerated.

Before test, No. 1 square concentrated solution (9.3g raw material/ml) with No. 16 gavage syringe needles and 1ml syringe not adding distil water dilution directly extract gavage (ig); No. 2 square concentrated solutions (11.8g raw material/ml) need adding distil water to be diluted to 10.2g raw material/ml, then extract with No. 16 gavage syringe needles and 1ml syringe. Mouse ig volume 0.2ml/10gBW.

1.2 animals: SPF level KM kind mouse, totally 40, half and half, body weight 20��22g, laboratory animal production licence number: SCXK (capital) 2009-0017 female, male, examining and determine research institute's Laboratory Animal Resource center by Chinese food medicine provides. Mouse by 10, the every cage of sex, laboratory animal room's breeding observing after 3 days for test. Before test, mouse fasting 16 hours, can't help water.

1.3 laboratory animal room: be barrier environment, fully-closed state, three-stage filtration is blown, temperature 22��24 DEG C, relative humidity 40��45%, fluorescent lamp 12 hr light, laboratory animal occupancy permit number: SYXK (capital) 2011-0008. Autoclaving wood wool bits are bedding and padding. Little mouse cage volume 29 �� 18 �� 12cm of plastics, Stainless Steel Wire top cover. SPF big and small mouse upgrowth breeding feed for Beijing Australia of section pull together feed corporation,Ltd provide, examination conformity certification number: capital raises careful (2009) 06166, product batch number: 13103123. Laboratory animal room of the court provides purified water freely to drink.

1.4 main Apparatus and instruments

1/10 animal electronic balance is measured in sense, and 1/1000 electronic balance is measured in sense, 50ml beaker, 1ml disposable syringe, dissects plate, medical scissors and tweezers.

2. test method

Get the fasting mouse of 16 hours and it is divided into 2 groups, often organize each 10 of male and female. Giving tested material suspension according to every mouse body weight ig, give at 2 times (5 hours, interval) in one day, No. 1 side's group accumulation is 372g raw material/kgBW to sample amount; No. 2 side's group accumulations are 408g raw material/kgBW to sample amount. Untoward reaction and the death state of animal on the 14th is observed continuously after giving tested material. Record the mouse body weight to sample 0,3,7 and 14 days.

3. result

The same day, ig observed 4 hours after giving tested material continuously, and mouse is in high spirits, and behavior is normal, freely, respiratory rate is unchanged in activity, and the weak stimulations such as the sound is responsive, excited or suppress behavior without spirit, have no rare just, the urinary incontinence, mouth, nasal bleeding and conjunctival congestion etc. When second time gives tested material crawl mouse, it is seen that black is soft just discharges, have no other toxic reactions and occur. Next day, mouse was moistened by hair, and activity freely, is breathed evenly, and reaction is quick, and feed intake, drinking-water etc. are all normal, have black ight soil to discharge. Observe mouse on the 14th continuously and do not find any new abnormal response or death. Survival mice mean body weight increases by 10��16g in the meantime. Refer to table 1.

Table 1 whets the appetite drink to the observation of Mouse Acute Toxicity reaction

Contamination full 14 days de-cervical vertebras put to death mouse, dissect each internal organs and carry out gross examination of skeletal muscle: brain is without hemorrhage and ponding; The congestive liquid in thoracic cavity, the heart, lung not enlargement, without hemostasis; Abdominal cavity is without long-pending liquid, each organ adhesion, liver, spleen, kidney smooth surface, not enlargement, without tubercle, in stomach, food is more, enteric cavity is without flatulence, there is ight soil in coton and rectal, each histoorgan is complete, color and luster is ruddy, has no the abnormalities such as enlargement, enclosed mass, ulcer, atrophy, necrosis, hyperemia and hemostasis.

Being grown up by 60kg body weight calculating oral dose is 1.03g raw material/kgBW. No. 1 side's group accumulation is 372g raw material/kgBW to sample amount, is equivalent to 360 times of clinical people's consumption; No. 2 side's group accumulations are 408g raw material/kgBW to sample amount, are equivalent to 396 times of clinical people's consumption.

4. conclusion

2 times on the one ig contaminations of KM kind mouse, observe 14 continuously, have no obvious toxic reaction and death. Its LD₅₀Amount > 372g/kg, according to acute toxicity (LD₅₀) dosage grade scale belongs to nontoxic rank.

Set forth the preparation method of said composition beverage and chewable tablet by the following examples further:

Embodiment 1

The preparation method of Fruit of Pashi Pear beverage for improving appetite (formula 1):

1.1 crude drugs arrange to be concocted:

1.1.1 hawthorn, roasted malt, dried orange peel, stir-fry Semen Raphani, sweet fennel, Buddha's hand, sea-buckthorn, Radix Glycyrrhizae, cassia bark, meet the Pharmacopoeia of the People's Republic of China 2010 editions one regulation. Meet " new resource food list and be food and drug list " that the Ministry of Health announces

Consumption is hawthorn 50 parts, roasted malt 15 parts, dried orange peel 10 parts, fries Semen Raphani 20 parts, sweet fennel 8 parts, Buddha's hand 8 parts, sea-buckthorn 15 parts, 8 parts, Radix Glycyrrhizae, 8 parts, cassia bark, xylo-oligosaccharide 5 parts, potassium sorbate 0.5 part.

1.1.2 xylo-oligosaccharide meets QB/T2984-2008 regulation, and potassium sorbate meets GB13736-2008 regulation.

1.2. extract:

Fill a prescription according to Fruit of Pashi Pear beverage for improving appetite, take hawthorn, roasted malt, dried orange peel, stir-fry Semen Raphani, sweet fennel, Buddha's hand, sea-buckthorn, Radix Glycyrrhizae, cassia bark, the times amount water that adds 10, it is heated to 70 DEG C, Shenzhen's remittance hundred million is adopted to reach the immerseable KESP-100KH ultrasonic extraction device of mechanical & electronic equipment corporation, Ltd's production, extract 3 times, extract about 50min every time; Filter, merging filtrate.

1.3 concentrate:

1.4 batchings:

This operating post is D level clean area. Check verification the concentrated solution intermediate name of an article, specification, lot number, quantity. Xylo-oligosaccharide, potassium sorbate, purified water 16 times is added by formula for a product respectively by above-mentioned concentrated solution, heat 30 minutes, leave standstill 24 hours precipitations, filter, contain in clean all turning barrels after being up to the standards, indicate name of product, lot identification mark, specification, quantity, operator's name, it is transported to subsequent processing in time, bucket overcoat clean plastics bag during transhipment.

1.5 is filling:

This operating post is D level clean area. The liquid prepared is transported to bottling department, carry out filling, filling outwards open in draw ring pop can (310ml/ tank) sealing, sterilizing. Indicate name of product, lot identification mark, specification, quantity, operator's name.

1.6 outer packagings: outer packaging adopts Corrugated Box.

1.7 inspections: check according to company standard.

1.8 warehouse-ins: product can be put in storage after being up to the standards.

Embodiment 2

The preparation method of Fruit of Pashi Pear appetizing chewable tablet:

2.1 crude drugs arrange to be concocted:

2.1.1 hawthorn, roasted malt, dried orange peel, stir-fry Semen Raphani, sweet fennel, Buddha's hand, sea-buckthorn, Radix Glycyrrhizae, cassia bark, meet the Pharmacopoeia of the People's Republic of China 2010 editions one regulation. Meet " new resource food list and be food and drug list " that the Ministry of Health announces.

2.2. extract:

According to Fruit of Pashi Pear appetizing formula of chewable tablets, take hawthorn, roasted malt, dried orange peel, stir-fry Semen Raphani, sweet fennel, Buddha's hand, sea-buckthorn, Radix Glycyrrhizae, cassia bark, the times amount water that adds 10, it is heated to 70 DEG C, Shenzhen's remittance hundred million is adopted to reach the immerseable KESP-100KH ultrasonic extraction device of mechanical & electronic equipment corporation, Ltd's production, extract 3 times, extract about 50min every time; Filter, merging filtrate.

2.3 concentrate:

3.4 batchings:

This operating post is D level clean area. Check verification the concentrated solution intermediate name of an article, specification, lot number, quantity. Add xylo-oligosaccharide, potassium sorbate by formula for a product respectively by above-mentioned concentrated solution, then add starch 16 times, contain in clean all turning barrels, mix and blend 10min, it is ensured that evenly, make it to become dough. Indicate name of product, lot identification mark, specification, quantity, operator's name, it is transported to subsequent processing in time, bucket overcoat clean plastics bag during transhipment.

1.5 film-makings:

This operating post is D level clean area. The dough medicine prepared is transported to film-making workshop, carries out film-making, the heavy 1g of every sheet. 100 every bottle, sealing, sterilizing. Indicate name of product, lot identification mark, specification, quantity, operator's name.

1.6 outer packagings: outer packaging adopts Corrugated Box.

1.7 inspections: check according to company standard.

Embodiment 3

The preparation method of Fruit of Pashi Pear aperitif (formula 2):

3.1 crude drugs arrange to be concocted:

3.1.1 hawthorn, roasted malt, dried orange peel, stir-fry Semen Raphani, sweet fennel, Buddha's hand, sea-buckthorn, Radix Glycyrrhizae, cassia bark, Fructus Sinopodophylli, the stem of noble dendrobium all meets the Pharmacopoeia of the People's Republic of China 2010 editions one regulation. Meet " new resource food list and be food and drug list " that the Ministry of Health announces.

Consumption is hawthorn 50 parts, roasted malt 15 parts, dried orange peel 10 parts, fries Semen Raphani 20 parts, sweet fennel 8 parts, Buddha's hand 8 parts, sea-buckthorn 15 parts, 8 parts, Radix Glycyrrhizae, 8 parts, cassia bark, Fructus Sinopodophylli 5 parts, the stem of noble dendrobium 3 parts, xylo-oligosaccharide 5 parts, potassium sorbate 0.5 part.

3.1.2 xylo-oligosaccharide meets QB/T2984-2008 regulation, and potassium sorbate meets GB13736-2008 regulation.

3.2 extract:

Whet the appetite formula ratio according to Fruit of Pashi Pear, take hawthorn, roasted malt, dried orange peel, stir-fry Semen Raphani, sweet fennel, Buddha's hand, sea-buckthorn, Radix Glycyrrhizae, cassia bark, Fructus Sinopodophylli, the stem of noble dendrobium, the times amount water that adds 10, be heated to 70 DEG C, extract 3 times, extract about 50min every time; Filter, merging filtrate.

3.3 concentrate:

It is 1.20-1.30, pH3.0-4.0 that merging filtrate is evaporated to relative density, obtains concentrated solution.

3.4 batchings:

The foregoing is only the better embodiment of the present invention, and it is not used to limit the substantial technological context of the present invention, the substantial technological content of the present invention is broadly defined in the right of application, any technology entities that other people complete or method, if with application right define completely identical, or the change of a kind of equivalence, also all it is covered by being regarded as among this right.

Reference

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(5) Wang Xiong, Wu Jinhu. the research overview of Fructus Hordei Germinatus. Chinese medicinal materials 2010 (09): 1503-1508

(6) Zhao Xiuling. dried orange peel physiologically active ingredient research progress. foodstuffs industry science and technology, 2013,12 phases 376-381)

(7) Li Hong. Semen Raphani modern study overview (summary). Beijing University of Chinese Medicine's journal, 2001 (03): 67-69

(8) Yin Liduan, Wang Lizhi, Dong Congchao. the application of xylo-oligosaccharide in functional foodstuff. processing of farm products industry .2003,6:.29-31

(9) Zhang Darong, Yin Ji. xylo-oligosaccharide is in the clinical application improved in intestinal function disorder. food science and technology, 2007,10:125-126.

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Claims

1. a Fruit of Pashi Pear aperitif and beverage, it is characterised in that it comprises following bulk drug: hawthorn, roasted malt, dried orange peel, stir-fry Semen Raphani.

2. a Fruit of Pashi Pear aperitif and beverage, it is characterised in that it is made up of the bulk drug of following weight proportion: hawthorn 20-70 part, roasted malt 7-20 part, dried orange peel 5-15 part, stir-fry Semen Raphani 10-30 part, sweet fennel 5-10 part, Buddha's hand 5-10 part, sea-buckthorn 10-20 part, Radix Glycyrrhizae 6-12 part, cassia bark 5-10 part, xylo-oligosaccharide 2-10 part, potassium sorbate 0.3-0.6 part.

3. a kind of Fruit of Pashi Pear aperitif and beverage according to claim 2, it is characterised in that it is made up of the bulk drug of following weight proportion: hawthorn 50 parts, roasted malt 15 parts, dried orange peel 10 parts, fry Semen Raphani 20 parts, sweet fennel 8 parts, Buddha's hand 8 parts, sea-buckthorn 15 parts, 8 parts, Radix Glycyrrhizae, 8 parts, cassia bark, xylo-oligosaccharide 5 parts, potassium sorbate 0.5 part.

4. the preparation method of a kind of Fruit of Pashi Pear aperitif according to Claims 2 or 3 and beverage, it is characterised in that it comprises the following steps:

A. extract: according to formula, take hawthorn 50 parts, roasted malt 15 parts, dried orange peel 10 parts, fry Semen Raphani 20 parts, sweet fennel 8 parts, Buddha's hand 8 parts, sea-buckthorn 15 parts, 8 parts, Radix Glycyrrhizae, 8 parts, cassia bark, the times amount water that adds 10, it is heated to 70 DEG C, adopt ultrasonic extraction device, extract 3 times, extract about 50 minutes every time, filter, merging filtrate; Obtain;

Described Semen Raphani adopts microwave oven frying method: microwave big fire, and heating 3.5min, to obtain final product;

B. concentrate: it is 1.20-1.30, pH3.0-4.0 that merging filtrate is evaporated to relative density, to obtain final product;

C. prepare burden: add xylo-oligosaccharide, potassium sorbate by formula for a product respectively by above-mentioned concentrated solution, drop in V-type mixing tank, add 16 times of 38 degree of white wine or grape Portugal wine afterwards again, mix and blend 10min, guarantee evenly, leave standstill 24 hours precipitations, get supernatant liquor and put into filling machine, filling in glass wine bottle, to obtain final product.

5. a Fruit of Pashi Pear appetizing composition, it is characterised in that it is made up of the bulk drug of following weight proportion: hawthorn 20-70 part, roasted malt 7-20 part, dried orange peel 5-15 part, stir-fry Semen Raphani 10-30 part, sweet fennel 5-10 part, Buddha's hand 5-10 part, sea-buckthorn 10-20 part, Radix Glycyrrhizae 6-12 part, cassia bark 5-10 part, xylo-oligosaccharide 2-10 part, potassium sorbate 0.3-0.6 part.

6. a kind of Fruit of Pashi Pear appetizing composition according to claim 5, it is characterised in that it is made up of the bulk drug of following weight proportion: hawthorn 50 parts, roasted malt 15 parts, dried orange peel 10 parts, fry Semen Raphani 20 parts, sweet fennel 8 parts, Buddha's hand 8 parts, sea-buckthorn 15 parts, 8 parts, Radix Glycyrrhizae, 8 parts, cassia bark, xylo-oligosaccharide 5 parts, potassium sorbate 0.5 part.

7. according to claim 5 or 6 a kind of Fruit of Pashi Pear appetizing composition preparation method, it is characterised in that, bulk drug adds purified water 16 times, heat 30 minutes, leave standstill 24 hours precipitation, filtration, obtain Fruit of Pashi Pear beverage.

8. the preparation method of a kind of Fruit of Pashi Pear appetizing composition according to claim 5 or 6, it is characterised in that, various conventional auxiliary materials required when the different preparations adding the license of the clinical human body acceptable Pharmacopoeia of the People's Republic of China become agent, to obtain final product.

9. according to claim 5 or 6 a kind of Fruit of Pashi Pear appetizing composition preparation method, it is characterised in that, add starch 16 times, contain in clean all turning barrels, mix and blend 10min, it is ensured that evenly, make it to become dough, compression molding, obtain Fruit of Pashi Pear chewable tablet.