CN105559797A - Portable dynamic continuous blood glucose monitoring instrument oriented at medical IoT (Internet of Things) - Google Patents
Portable dynamic continuous blood glucose monitoring instrument oriented at medical IoT (Internet of Things) Download PDFInfo
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Abstract
The invention discloses a portable dynamic continuous blood glucose monitoring instrument oriented at medical IoT (Internet of Things). The monitoring instrument comprises a spiral type Pt(platinum)-Ir(iridium) sensing electrode, a blood glucose information collector and a network handheld terminal, wherein the electrode comprises a Pt-Ir wire coated with a coating, auxiliary electrodes arranged on the Pt-Ir wire in a surrounding manner and a spiral type work electrode formed at the end part of the Pt-Ir wire. The blood glucose information collector is in series connection with the spiral type Pt-Ir sensing electrode, and the network handheld terminal is connected with the blood glucose information collector through the IoT. The service life of the blood glucose monitoring instrument is long, the blood glucose information collector is portable and has long-term dynamic data collection capacity, the network handheld terminal can provide a good blood glucose data feedback interface and can provide reliable asymptomatic blood glucose information, information transmission between the collector and the handheld terminal is realized with the IoT technique, a hardware platform is provided for dynamic monitoring of multiple patients in a hospital in a following period, and a hardware platform is provided for a specialist system for blood glucose treatment.
Description
Technical field
The invention belongs to intelligent sensing technology field, be specifically related to a kind of portable dynamic continuous blood sugar monitor for treating diabetes, mainly overcome that the patient compliance existed in existing monitoring technology is poor, data single with carry the problems such as inconvenience, be expected to be widely used in the fields such as blood sugar test.
Background technology
Diabetes, as a stealthy killer of health, are one of diseases that patient is maximum in the world at present.Prevalence eighties in last century of China's diabetes is 0.84%, develop into 9.7%, and the investigation of 2010 is 11.6%, adds 12.8 times between more than 20 years by 2007.Infer diabetes mellitus in China number of patients about more than 9,000 ten thousand people thus, this numeral short 3 years China compared with 2007 just adds 2,200 ten thousand diabetes patients.If do not controlled, after 10 years, prevalence will reach about 20%.Diabetes are noninfectiouss that fatality rate is number three after tumor, cardiovascular and cerebrovascular vessel, and are the first causes causing renal failure.Therefore, the control of diabetes patient is also as the focus of following Ministry of Public Health.Blood sugar test is as detecting the important means with diagnosis and treatment diabetes, and have huge market in the whole world, annual sales volume more than 10,000,000,000 U.S. dollars, and increases year by year.
At present, diabetics mainly adopts second filial generation hand-held blood glucose meter to detect, this detection mode is relatively convenient and cheap, but has following shortcoming: adopt every day and get blood pin and on finger, gather tip blood sample can bring physiology and psychological burden to patient; Can not provide Continuous Glucose data, particularly motion rule that is rear and post-prandial glucose concentration change cannot be controlled; If injection of insulin is excessive, the death that hypoglycemic coma brings is uncertain.By carrying Dynamic Blood Glucose Monitoring equipment, diabetics is carried out monitoring to be generally believed it is best diagnosis and treatment mode by international academic community continuously.Dynamic Blood Glucose Monitoring (CGMS) identifiable design silent hypoglycemia, the cause of the death of the diabetics of about 2% is hypoglycemia.There is Hypoglycemic symptoms and comparatively hide in old-aged diabetic, and silent hypoglycemia incidence rate is higher, and therefore, the dynamic glucose spectrum that CGMS provides, is even more important to clinical diabetes treatment and education.
At present, mainly contain three sections of Dynamic Blood Glucose Monitoring instrument by U.S. food and Bureau of Drugs Supervision's certification in the world, wherein the continuous blood sugar monitoring equipment of a new generation of Medtronic Inc.'s research and development is sold at home, primarily of two part compositions: flat membrane platinum electrode and data acquisition catcher.Data acquisition and data are stored display and are combined as a whole by this design, but volume, power consumption are all larger, and history data store is limited in one's ability.In addition, the flat structure due to electrode makes the content of glucoseoxidase limited, thus limits electrode life, and therefore this equipment is mainly used in monitoring the blood sugar concentration data within patient 72h.This equipment volume is large, somewhat expensive, makes troubles, be used for the ICU ward of hospital to patient's routine use.At home, Zhejiang Huzhou Sheng Meidinuo develops the blue subcutaneous dynamic glucose monitoring system of the 1st section of implantable thunder, and its working life is also no more than 72h.Cai Xinxia seminar of CAS Electronics Research Institute devises a low power-consumption blood glucose meter based on MSP430F1611 chip, within the scope of concentration of glucose 5-200 μm ol/L, have the linearity.Up to the present, also do not have 1 section the sensor of long-term work (>60 days) industrialization can be realized, this is because traditional design is in order to reduce the body defenses/repulsion after device implantation, most employing needle electrode, thus the loading of glucoseoxidase is few, causes working life to be no more than 3 days.
Summary of the invention
Object of the present invention develops a kind of portable dynamic continuous blood sugar instrument of internet of things oriented, to realize monitoring continuously the long-term dynamics of human blood glucose concentration.
In order to achieve the above object, the invention provides a kind of portable dynamic continuous blood sugar monitor towards medical Internet of Things, this monitor comprises: screw type platinum-iridium sensing electrode, blood glucose information harvester and network hand-hold terminal;
Described screw type platinum-iridium sensing electrode comprises:
Coated cated Pt-Ir silk;
Around the auxiliary electrode be arranged on Pt-Ir silk; And
The screw type working electrode formed by Pt-Ir silk end;
Described blood glucose information harvester comprises: primary processor, current/voltage testing circuit, Zigbee module, power control circuit, output voltage controlling circuit and power module;
Described network hand-hold terminal comprises: primary processor, eeprom circuit, display screen, Zigbee module, power module, power control circuit and serial port module;
Described blood glucose information harvester is connected with screw type platinum-iridium sensing electrode, and described network hand-hold terminal is connected by Internet of Things with blood glucose information harvester.
Described working electrode comprises:
The Pt-Ir coil that the Pt-Ir silk removing coating by coated cated Pt-Ir silk end is formed, it has spiral cavity;
Embed the GOD carrier be arranged in Pt-Ir coil;
Drip and be coated with the GOD of load on GOD carrier and Pt-Ir coil;
Be coated in the Epoxy-PU semipermeable membrane of Pt-Ir coil outer, and
Be arranged on the encapsulating film at screw type working electrode two ends.
Described auxiliary electrode is Ag/AgCl silk electrode, and described GOD carrier selects any one or a few the combination in Medical cotton, silk, porous carbon fiber; Described Epoxy-PU semipermeable membrane is made up of oxolane, polyurethane, dodecyl polytetroxide vinyl Ether and double-component epoxy adhesive; Described coating is polytetrafluorethylecoatings coatings or PEP coating.
The output voltage controlling circuit of described blood glucose information harvester is made up of DA output circuit, voltage follower circuit and AD feedback circuit, and this output voltage controlling circuit applies a running voltage under the control of primary processor spiral platinum-iridium working electrode.
The current/voltage testing circuit of described blood glucose information harvester comprises current/voltage circuit, filter circuit, voltage hold circuit and microprocessor; This current/voltage testing circuit is connected with auxiliary electrode, converts current signal to voltage signal, and carries out hardware filtering process to voltage signal; Voltage signal is passed through analog/digital conversion and formula scales by described microprocessor, again by software filtering process, draw current blood glucose concentration data, the Frame comprising blood glucose information is sent to handheld terminal by Zigbee wireless transport module by the primary processor of blood glucose information harvester.
Described blood glucose information harvester is in resting state or duty, the resting state time is greater than the duty time, and (most of the time is in resting state, wake up when needing, in running order), its resting state is waken up by Internet of Things wireless receiving exterior terminal (e.g., network hand-hold terminal).
When described blood glucose information harvester is in resting state, primary processor is by carrying out the power supply supply of cut-off current testing circuit to the control of power module, current/voltage testing circuit is not worked, and primary processor and Zigbee module are all in the outside awakening mode of low-power consumption.
Described network hand-hold terminal by Zigbee module receive by blood glucose information harvester by Internet of Things send return data and be stored in EEPROM,
Described network hand-hold terminal also comprises button and display screen, described network hand-hold terminal is in resting state or duty, and (most of the time is in resting state, wake up when needing, in running order), when it is in resting state, user by the network hand-hold terminal in key wakeup dormancy, and controls on current blood glucose value and real time blood sugar change curve or historical variations curve display display screen.
The primary processor of described network hand-hold terminal is also provided with hyperglycemia threshold value and hypoglycemia threshold value respectively, and the blood sugar concentration collected when primary processor, higher than described hyperglycemia threshold value, can send hyperglycemia warning message; The blood sugar concentration collected when primary processor, lower than described hypoglycemia threshold value, can send hypoglycemia warning message.
The present invention devises a kind of novel screw type platinum-iridium electrode as sensing element, and the blood glucose information harvester matched with this electrode (it has the small electrical chem workstation of wireless transmitting function) and network hand-hold terminal.Novel electrode structure of the present invention can improve the loading of glucoseoxidase, reduces the enzyme deactivation ratio after implanting, thus obtains the service life of 1-2 month; And harvester of the present invention has, and volume is little, the feature such as low-power consumption and convenient data transmission, will be convenient to patient and carry for a long time.Adopt Internet of Things to transmit before harvester and handheld terminal, there is low-power consumption and move the feature of automatically searching net, adding, upgrading route with node location.Network hand-hold terminal, without the need to considering power consumption and capacity issue, makes whole system have the features such as Multi-function display, massive store and many coffrets, has good practicality and expansion.
Beneficial effect of the present invention:
1. the screw type platinum-iridium electrode in the present invention is relative with existing flat electrode, has the loading of larger glucoseoxidase, makes electrode have longer service life.
2. the blood glucose information harvester designed in the present invention is integrated with the partial function of electrochemical workstation, thus make electrochemical workstation miniaturization, while guarantee certainty of measurement, adopt the Strategy Design such as low-power consumption and wireless transmission, make harvester have the ability of long-term portable dynamic acquisition data.
3. the handheld terminal design in the present invention provides good blood glucose level data feedback interface, make patient and doctor can understand the blood glucose fluctuation information of patient in current and a period of time easily, especially reliable asymptomatic blood glucose information can be provided, so that as the treatment of patient and the foundation of prevention.
4. the miniaturization electrochemical workstation in the present invention, except measuring blood glucose, by amendment algorithm, and coordinates different ion selective electrodes can be applied to the fields such as chemistry, biology and environmental monitoring, thus realizes the hand-held of this quasi-instrument further.
5. the harvester in the present invention and between handheld terminal information transmission all adopt technology of Internet of things, this many patients dynamic monitoring being designed to later stage hospital provides hardware platform, and more the specialist system of glycemic therapeutic provides hardware platform.
Accompanying drawing explanation
Fig. 1 is the structural representation of a kind of portable dynamic continuous blood sugar monitor towards medical Internet of Things of the present invention.
Fig. 2 is the structural representation of the spiral platinum-iridium sensing electrode of a kind of portable dynamic continuous blood sugar monitor towards medical Internet of Things of the present invention.
Fig. 3 is the structural representation of the blood glucose information harvester of a kind of portable dynamic continuous blood sugar monitor towards medical Internet of Things of the present invention.
Fig. 4 is the structural representation of the network hand-hold terminal of a kind of portable dynamic continuous blood sugar monitor towards medical Internet of Things of the present invention.
Fig. 5 is the forward and backward and linear compensation testing current Error Graph of correcting current, and the linear matched curve illustration of theory and practice electric current.
Fig. 6 be a kind of portable dynamic continuous blood sugar monitor towards medical Internet of Things of the present invention to the timing Ampere currents response curve of different concentration of glucose, and the current-responsive linear fit illustration of different concentration of glucose.
Detailed description of the invention
Technical scheme of the present invention is described in detail below in conjunction with accompanying drawing.
As shown in Figure 1, for the invention provides a kind of portable dynamic continuous blood sugar monitor towards medical Internet of Things, this monitor comprises: screw type platinum-iridium sensing electrode, blood glucose information harvester and network hand-hold terminal, described blood glucose information harvester is connected with screw type platinum-iridium sensing electrode, and described network hand-hold terminal is connected by Internet of Things with blood glucose information harvester.
As shown in Figure 2, described screw type platinum-iridium sensing electrode comprises:
Coated cated Pt-Ir(is preferably 90%Pt-10%Ir) silk 1;
Around the auxiliary electrode 2 be arranged on Pt-Ir silk, be preferably Ag/AgCl silk electrode; And
The screw type working electrode formed by an end of Pt-Ir silk 1;
Described screw type working electrode comprises:
The Pt-Ir coil 6 that the Pt-Ir silk removing coating by coated cated Pt-Ir silk 1 end is formed, it has spiral cavity; Described coating is polytetrafluorethylecoatings coatings or PEP coating;
Embed the GOD carrier 7 be arranged in Pt-Ir coil 6; Described GOD carrier selects any one or a few the combination in Medical cotton, silk, porous carbon fiber;
Drip and be coated with load at GOD(glucoseoxidase) GOD5 on carrier 7 and Pt-Ir coil 6;
Be coated in the Epoxy-PU semipermeable membrane 4 of Pt-Ir coil 6 outside, described Epoxy-PU semipermeable membrane is made up of oxolane, polyurethane, dodecyl polytetroxide vinyl Ether and double-component epoxy adhesive; And
Be arranged on the encapsulating film 3 at screw type working electrode two ends.
The preparation method of described screw type platinum-iridium sensing electrode is: by Pt-Ir(90%Pt-10%Ir) tinsel (diameter is 0.125mm) electrode of working, and a spiral cavity is made in its one end, external diameter is 1mm, and internal diameter is 0.85mm, and length is 2 ~ 3mm; The carrier adsorbing glucoseoxidase (e.g., fibrefill) is filled in this cavity; Sealed at screw electrode cavity two ends, and drip for screw electrode is outer the semi-transparent rete coating good biocompatibility, this rete is primarily of polyurethane (PU) and epoxy resin (Epoxy); By the Ag silk of teflon-coated, diameter is 0.125mm, or after superchlorination, forms Ag/AgCl silk, as auxiliary electrode.On this basis, the auxiliary electrode made is wound around on the working electrode (s, thus makes blood sugar concentration detecting electrode of the present invention (that is, screw type platinum-iridium sensing electrode).
Described blood glucose information harvester comprises: primary processor, current/voltage testing circuit, Zigbee module, power control circuit, output voltage controlling circuit and power module; Described current/voltage testing circuit, Zigbee module, power control circuit, output voltage controlling circuit and power module are all connected with primary processor signal, and other annexations as shown in Figure 3.
Output voltage controlling circuit is made up of DA output circuit, voltage follower circuit and AD feedback circuit, and it applies a running voltage under the control of primary processor spiral platinum-iridium working electrode.There is electrochemical reaction in the blood glucose solution between working electrode and auxiliary electrode, glucose (Glucose) and oxygen (O under the catalytic action of glucoseoxidase (GOD)
2) act on generation gluconic acid (Gluconicacid) and hydrogen peroxide (H
2o
2), apply the voltage of 0.4 ~ 0.7V on the working electrode (s, decompose hydrogen peroxide into oxygen, proton and electronics, thus form micro-electric current.Micro-electric current that the present invention will generate after emphasis detection reaction, thus obtain blood glucose concentration value.
Current/voltage testing circuit comprises current/voltage circuit, filter circuit, voltage hold circuit and microprocessor.This testing circuit is connected with auxiliary electrode, converts current signal to voltage signal, and carries out hardware filtering process to voltage signal.Voltage signal is passed through analog/digital conversion and formula scales by microprocessor, then by software filtering process, draws current blood glucose concentration data, and the Frame comprising blood glucose information is sent to network hand-hold terminal by Zigbee wireless transport module by primary processor.
The worn for long periods being designed for patient due to the present invention uses, and therefore, the present invention designs and the size of the harvester wiring board prepared is only 40*30mm.System power dissipation is the Zigbee of design alternative lowest power is transmission means, and can the transmission of multinode MANET.In addition, the node sample cycle is about 5mins.
For low-frequency sampling requirement of the present invention, the wake-up mode of Internet of Things wireless receiving exterior terminal selected by harvester, and system is in resting state for a long time.Between rest period, primary processor (MCU) and Zigbee module are all in the outside awakening mode of low-power consumption, and static current of lcd only has hundreds of microampere order.Between rest period, current/voltage testing circuit does not also need work, in order to reduce the static state consumption of whole harvester, primary processor (MCU), by the power supply supply by controlling cut-off current testing circuit to power supply chip, really realizes realizing system ' zero ' power consumption when not needing collecting work.Through detecting, this node average power consumption is about 0.4mW, as powered by the button cell of small size (rated voltage is 3V, and capacity is 540mWh), whole system energy continuous firing 1-2 month, avoids the frequent inconvenience changed battery and bring to patient.
Described network hand-hold terminal mainly comprises: primary processor, eeprom circuit, display screen (being preferably LCD display circuit), Zigbee module, power module, power control circuit, serial port module, button and display screen; Described eeprom circuit, display screen, Zigbee module, power module, power control circuit, serial port module, button and display screen are all connected with primary processor signal, and other annexations as shown in Figure 4.
Network hand-hold terminal as Zigbee coordinator end in Internet of Things, be responsible for receive by blood glucose information harvester by Internet of Things send return data and be stored in EEPROM, 32768 groups of data can be stored at most; User is by the handheld terminal in key wakeup dormancy, and control current blood glucose value and real time blood sugar change curve or historical variations curve to be presented on color LCD screen, patient is facilitated to check own blood glucose situation, after display a period of time, system will reenter resting state, and (the network hand-hold terminal most of the time is in resting state, wake up when needing, in running order), wait for and waking up next time.
The primary processor of described network hand-hold terminal is also provided with hyperglycemia threshold value and hypoglycemia threshold value respectively, and the blood sugar concentration collected when primary processor, higher than described hyperglycemia threshold value, can send hyperglycemia warning message; The blood sugar concentration collected when primary processor, lower than described hypoglycemia threshold value, can send hypoglycemia warning message.The present invention is by the high and low blood glucose alarm mechanism of design, thus prompting patient does corresponding treatment process, and when this mechanism will be slept soundly to patient, asymptomatic hypoglycemia emergency case has good prompting function.All data that terminal is also stored by serial communication circuit where necessary are directly uploaded to PC host computer, transfer to host computer to show, store and analyzing and processing, these data will be formulated therapeutic scheme and provide complete blood glucose level data foundation to doctor.
Below in conjunction with drawings and Examples, the specific embodiment of the present invention is further described.Wherein, embodiment 1 mainly sets forth the electrode fabrication of monitoring system, and embodiment 2 and 3 is mainly system test and effect analysis.
Embodiment 1
Electrode process makes and is summarized as follows: it closely spirals along hypodermic needle (30gauge) and is wound around 5-8 circle by the medical grade platinoiridita silk that (1) chooses 4-7cm, and obtain external diameter and be about 1mm, internal diameter is about the Pt-Ir coil of 0.85mm; (2) a small gangs of fibrous material is embedded in coil, fix carrying capacity in order to improve GOD; (3) adopt the method for classical chemical crosslinking, with glutaraldehyde (GA) for cross-linking agent, GOD and bovine serum albumin (BSA) are mixed with oxidase solution, and on shaking table, make its Homogeneous phase mixing; (4) pipette 8 μ L oxidase solution with the liquid-transfering gun of 10 μ L to drip and to be coated onto above electrode twice, wherein drip that to be coated with time interval be 30mins, then allow modified electrode dry 1h under room temperature environment; (5) then Epoxy-PU solution is dripped and be coated onto on the enzyme electrode of different formulations, be then placed in 80 DEG C of thermostatic drying chambers and solidify 20mins; (6) by the Ag silk of teflon-coated, or after superchlorination, Ag/AgCl silk is formed, as auxiliary electrode; (7) auxiliary electrode made is wound around on the working electrode (s.The electrode prepared, is placed in the phosphate buffer (PBS) of 0.15M, and cold preservation under 4 DEG C of environment.
Embodiment 2
Real impedance load testing is the function in order to verificating current testing circuit, and improves accuracy of detection by Circuit tuning parameter and software algorithm on this basis.In real impedance test environment, adopt load to be 10M Ω resistance, running voltage is that 0 ~ 1V is adjustable, and each adjustment stride is 0.1V, and corresponding current scope is 0 ~ 100nA.On the basis of this external basic test, leading applying hardware parameter corrects and tests, on software, apply parameter correction afterwards again test again, three test Contrast on effects as shown in Figure 5, testing current error after result display system soft and hardware parameter correction, than decrease to some degree before correcting, and linear compensation has been done on basis after calibration again, the effect of gained is better.Test result shows that system power signal is within the scope of 0-30nA, its relative error is comparatively large, and error tends towards stability gradually within 30 ~ 100nA scope, and error amount is less, can infer further from above trend, the measurement error scope of more than 100nA is expected to control about 1 ‰.Illustration in figure mainly shows linear relationship and the relative difference of the actual measuring current after theoretical measuring current and calibrated compensation, and contrast can find that the linearity of actual measuring current value and theoretical current value is suitable, and relative difference becomes large along with the increase of electric current.
Embodiment 3
Above system is adopted to carry out solution testing, by screw type platinum-iridium working electrode and Ag/AgCl auxiliary electrode, be placed on respectively with PBS be substrate glucose mixed solution in, glucose solution selects seven concentration such as 0mM, 2mM, 5mM, 10mM, 15mM, 20mM, 25mM to test, and its running voltage is 0.7V.Method of testing: first testing concentration of glucose is the PBS substrate solution of 0mM, has just started as larger electrode polarization electric current, after current reduce, wait for 3-5 minute, treat that electric current is basicly stable; Then press concentration formula again and drip glucose solution, observing response electric current also records data, and wherein must wait for reaching capacity to current flow for 3-5 minute before each dropping, test result as shown in Figure 6.The impedance of solution is astable value, so there is certain ripple in test curve, wherein comprise test noise, but electric current is more satisfactory with the variation tendency of solution concentration on the whole, the illustration of accompanying drawing 6 is the linear fit design sketch of kinetic current and solution concentration, the test result of whole test macro in real solution shows, the linearity that this system can remain intact between 2-25mM, linear fit coefficient R 2 reaches 99.71%, and test specification exceedes the testing requirement (2-15mM) of implanted sensor to the actual blood glucose of human body.Its sensitivity S=(I15 – I5)/10=22.8nA/mM, wherein I5 and I15 is respectively the current value added corresponding to 5mM and 15mM glucose solution.
More than test proof, a kind of portable dynamic continuous blood sugar monitor towards medical Internet of Things provided by the invention can meet the requirement in actual use of implanted sensor apparatus completely.
In sum, the long service life of blood sugar monitoring instrument provided by the invention, be convenient for carrying and can monitor continuously, its blood glucose information harvester has the ability of long-term portable dynamic acquisition data; Its network hand-hold terminal can provide good blood glucose level data feedback interface, reliable asymptomatic blood glucose information also can be provided, and, between harvester and handheld terminal, information transmission all adopts technology of Internet of things, for the later stage, many patients dynamic monitoring of hospital provides hardware platform, and more the specialist system of glycemic therapeutic provides hardware platform.
Although content of the present invention has done detailed introduction by above preferred embodiment, will be appreciated that above-mentioned description should not be considered to limitation of the present invention.After those skilled in the art have read foregoing, for multiple amendment of the present invention and substitute will be all apparent.Therefore, protection scope of the present invention should be limited to the appended claims.
Claims (10)
1. towards a portable dynamic continuous blood sugar monitor for medical Internet of Things, it is characterized in that, this monitor comprises: screw type platinum-iridium sensing electrode, blood glucose information harvester and network hand-hold terminal;
Described screw type platinum-iridium sensing electrode comprises:
Coated cated Pt-Ir silk (1);
Around the auxiliary electrode (2) be arranged on Pt-Ir silk (1); And
The screw type working electrode formed by Pt-Ir silk (1) end;
Described blood glucose information harvester comprises: primary processor, current/voltage testing circuit, Zigbee module, power control circuit, output voltage controlling circuit and power module;
Described network hand-hold terminal comprises: primary processor, eeprom circuit, display screen, Zigbee module, power module, power control circuit and serial port module;
Described blood glucose information harvester is connected with screw type platinum-iridium sensing electrode, and described network hand-hold terminal is connected by Internet of Things with blood glucose information harvester.
2., as claimed in claim 1 towards the portable dynamic continuous blood sugar monitor of medical Internet of Things, it is characterized in that, described screw type working electrode comprises:
The Pt-Ir coil (6) that the Pt-Ir silk removing coating by coated cated Pt-Ir silk (1) end is formed, it has spiral cavity;
Embedding is arranged on the GOD carrier (7) in Pt-Ir coil (6);
Drip and be coated with the GOD(5 of load on GOD carrier (7) and Pt-Ir coil (6));
Be coated in the Epoxy-PU semipermeable membrane (4) that Pt-Ir coil (6) is outside, and
Be arranged on the encapsulating film (3) at screw type working electrode two ends.
3. as claimed in claim 2 towards the portable dynamic continuous blood sugar monitor of medical Internet of Things, it is characterized in that, described auxiliary electrode (2) is Ag/AgCl silk electrode, and described GOD carrier (7) selects any one or a few the combination in Medical cotton, silk, porous carbon fiber; Described Epoxy-PU semipermeable membrane (4) is made up of oxolane, polyurethane, dodecyl polytetroxide vinyl Ether and double-component epoxy adhesive; Described coating is polytetrafluorethylecoatings coatings or PEP coating.
4. as claimed in claim 1 towards the portable dynamic continuous blood sugar monitor of medical Internet of Things, it is characterized in that, the output voltage controlling circuit of described blood glucose information harvester is made up of DA output circuit, voltage follower circuit and AD feedback circuit, and this output voltage controlling circuit applies a running voltage under the control of primary processor spiral platinum-iridium working electrode.
5. as claimed in claim 1 towards the portable dynamic continuous blood sugar monitor of medical Internet of Things, it is characterized in that, the current/voltage testing circuit of described blood glucose information harvester comprises current/voltage circuit, filter circuit, voltage hold circuit and microprocessor; This current/voltage testing circuit is connected with auxiliary electrode (2), converts current signal to voltage signal, and carries out hardware filtering process to voltage signal; Voltage signal is passed through analog/digital conversion and formula scales by described microprocessor, again by software filtering process, draw current blood glucose concentration data, the Frame comprising blood glucose information is sent to handheld terminal by Zigbee wireless transport module by the primary processor of blood glucose information harvester.
6. as claimed in claim 1 towards the portable dynamic continuous blood sugar monitor of medical Internet of Things, it is characterized in that, described blood glucose information harvester is in resting state or duty, the resting state time is greater than the duty time, and its resting state is waken up by Internet of Things wireless receiving exterior terminal.
7. as claimed in claim 6 towards the portable dynamic continuous blood sugar monitor of medical Internet of Things, it is characterized in that, when described blood glucose information harvester is in resting state, primary processor is by carrying out the power supply supply of cut-off current testing circuit to the control of power module, current/voltage testing circuit is not worked, and primary processor and Zigbee module are all in the outside awakening mode of low-power consumption.
8. as claimed in claim 1 towards the portable dynamic continuous blood sugar monitor of medical Internet of Things, it is characterized in that, described network hand-hold terminal by Zigbee module receive by blood glucose information harvester by Internet of Things send return data and be stored in EEPROM.
9. as claimed in claim 1 towards the portable dynamic continuous blood sugar monitor of medical Internet of Things, it is characterized in that, described network hand-hold terminal also comprises button and display screen, and described network hand-hold terminal is in resting state or duty, and the resting state time is greater than the duty time; When it is in resting state, user by the network hand-hold terminal in key wakeup dormancy, and controls current blood glucose value and real time blood sugar change curve or historical variations curve to be presented on screen.
10. as claimed in claim 1 towards the portable dynamic continuous blood sugar monitor of medical Internet of Things, it is characterized in that, the primary processor of described network hand-hold terminal is also provided with hyperglycemia threshold value and hypoglycemia threshold value respectively, the blood sugar concentration collected when primary processor, higher than described hyperglycemia threshold value, can send hyperglycemia warning message; The blood sugar concentration collected when primary processor, lower than described hypoglycemia threshold value, can send hypoglycemia warning message.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108366740A (en) * | 2016-08-08 | 2018-08-03 | 幸福软件有限公司 | Measure the portable complex sensor device and measurement method of multiple biological informations |
| CN110840430A (en) * | 2018-08-21 | 2020-02-28 | 北京万生人和科技有限公司 | Intra-abdominal pressure data screening method, computer-readable storage medium, and intra-abdominal pressure data screening device |
| CN111818184A (en) * | 2020-08-31 | 2020-10-23 | 创业慧康科技股份有限公司 | Medical Internet of things message routing device and method based on visual convenient flow calculation |
| CN111991003A (en) * | 2020-08-12 | 2020-11-27 | 上海萌草科技有限公司 | Savitzky-Golay filtering-based continuous blood glucose smoothing method, device, equipment and storage medium |
| CN115260836A (en) * | 2022-09-30 | 2022-11-01 | 北京深纳普思人工智能技术有限公司 | Reference electrode silver-silver chloride conductive ink for CGM and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1885863A (en) * | 2005-06-23 | 2006-12-27 | 杭州波导软件有限公司 | Health mobile phone |
| CN103989528A (en) * | 2014-06-05 | 2014-08-20 | 北京新兴阳升科技有限公司 | Integrated multi-parameter physiological state monitoring system |
-
2015
- 2015-12-23 CN CN201510976646.8A patent/CN105559797A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1885863A (en) * | 2005-06-23 | 2006-12-27 | 杭州波导软件有限公司 | Health mobile phone |
| CN103989528A (en) * | 2014-06-05 | 2014-08-20 | 北京新兴阳升科技有限公司 | Integrated multi-parameter physiological state monitoring system |
Non-Patent Citations (2)
| Title |
|---|
| BAZHANG YU ET.AL.: "COIL-TYPE IMPLANTABLE GLUCOSE", 《FRONTIERS IN BIOSCIENCE》 * |
| BAZHANG YU ET.AL.: "Use of hydrogel coating to improve the performance of implanted glucose sensors", 《BIOSENSORS AND BIOELECTRONICS》 * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108366740A (en) * | 2016-08-08 | 2018-08-03 | 幸福软件有限公司 | Measure the portable complex sensor device and measurement method of multiple biological informations |
| US10849541B2 (en) | 2016-08-08 | 2020-12-01 | Hexacheck Inc. | Portable complex sensor device for measuring multiple items of biometric information, and measurement method |
| CN108366740B (en) * | 2016-08-08 | 2021-07-13 | 六确认有限公司 | Portable composite sensor device for measuring multiple biological information and measuring method |
| CN110840430A (en) * | 2018-08-21 | 2020-02-28 | 北京万生人和科技有限公司 | Intra-abdominal pressure data screening method, computer-readable storage medium, and intra-abdominal pressure data screening device |
| CN110840430B (en) * | 2018-08-21 | 2022-09-13 | 北京万生人和科技有限公司 | Intra-abdominal pressure data screening method, computer-readable storage medium, and intra-abdominal pressure data screening device |
| CN111991003A (en) * | 2020-08-12 | 2020-11-27 | 上海萌草科技有限公司 | Savitzky-Golay filtering-based continuous blood glucose smoothing method, device, equipment and storage medium |
| CN111818184A (en) * | 2020-08-31 | 2020-10-23 | 创业慧康科技股份有限公司 | Medical Internet of things message routing device and method based on visual convenient flow calculation |
| CN111818184B (en) * | 2020-08-31 | 2020-12-15 | 创业慧康科技股份有限公司 | Medical Internet of things message routing device and method based on visual convenient flow calculation |
| CN115260836A (en) * | 2022-09-30 | 2022-11-01 | 北京深纳普思人工智能技术有限公司 | Reference electrode silver-silver chloride conductive ink for CGM and preparation method thereof |
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