CN1055297A - A kind of autofrettage of skin-moistening burn and scald medicine - Google Patents
A kind of autofrettage of skin-moistening burn and scald medicine Download PDFInfo
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Abstract
The method for making of a kind of ointment for treating burn and scald (" skin-moistening burn and scald peace ") by substrate and compatibility of drugs, substrate is the mixture of vegetable oil and cured (wax), medicine is a Chinese herbal medicine, concocts at a certain temperature.Processing procedure is easy, is applicable to I, II, III degree burn and scald that various exopathogenic factors cause, short treating period, cost saving, no pain in the treatment, the no cicatrix in healing back.Form skim infection matrix protection film, special effect at wound face after the drug of topical application.Through checking in clinical 3 years, cure rate 98.9%.Be a kind of easy to use, the burn and scald medicine of novel, the high curative effect that is suitable for applying.
Description
The present invention relates to the concocting method of the skin moistening burn and scald ointment of a kind of concocting method of pharmaceutical preparation, particularly a kind of external.
" burn and scald " is commonly encountered diseases in clinical, and along with the quickening of modern life rhythm, its sickness rate has the trend that increases year by year.
The Therapeutic Method of prior art, doctor trained in Western medicine are used debridement, sterilization, the drug of topical application, wrapping even operative treatment usually.Used Western medicine, mainly be infection, convergence ..., reasons such as, drug sensitivity poor owing to inadequate drainage, drug permeability, drug resistance cause the wound face dipping, infect, thereby its common defective is, the course of treatment is long, healing is slow, have that cicatrix maybe need be made skin graft, the expense height.
And dressing such as gauze stick on the wound surface, change dressings at every turn, cause suffering to patient.
Chinese medicine is the treasure of China, have in the recent period much and report about the improvement of treatment by Chinese herbs salve for treating burn and scald, for example, CN 86 1 08951 provides one " processing technology of low melting point ointment dosage form and moist expose burn ointment ", for implement exposure method, semi-exposure method under open condition, providing may.It is reported, be the better person in the existing Chinese medicine Paste for burns and scalds.
Through clinical verification, still undesirable though its therapeutic effect is better than Western medicine, also have traumatic infection, fever among the patient ... etc. symptom, its main deficiency remains, and the course of treatment is long, healing is slow, expense is high.
Purpose of the present invention will solve this difficult problem exactly.A kind of short treating period is provided, healing is fast, price is low, processing procedure is easy, the improvement technology of easy to use, the Paste for burns and scalds that is suitable for applying.
Task of the present invention is achieved in that
A kind of method for making that belongs to the skin moistening burn and scald ointment of ointment category is provided, and this skin moistening burn and scald ointment is made by substrate and compatibility of drugs, and feature of the present invention is:
(1) described substrate is the mixture that vegetable oil and cured (wax) matter are formed, and its weight ratio is vegetable oil: cured (wax) matter=1: 0.03～0.12,
(2) described vegetable oil can be to select in the middle of Oleum Ricini, Oleum Arachidis hypogaeae semen, Oleum sesami or Oleum Camelliae etc.,
(3) described cured (wax) matter can be to select in the middle of paraffin wax, Cera Flava or spermaceti etc.,
(4) described medicine can be medicine and/or its extract, is divided into four groups, wherein:
First component is to choose 2～3 kinds wantonly from Cortex Moutan, Radix Angelicae Sinensis, Radix Sanguisorbae, the Radix Angelicae Dahuricae and Radix Arnebiae (Radix Lithospermi),
Second component is to choose 2～3 kinds wantonly from Caulis Spatholobi, Cortex Phellodendri, Rhizoma Coptidis and Radix Et Rhizoma Rhei,
The 3rd component is to choose 1～2 kind wantonly from Olibanum, Myrrha and Sanguis Draxonis,
The 4th component is from Moschus, Borneolum Syntheticum, succinum and Mirabilitum crystallina optional 1～2 kind, and its weight ratio is,
Substrate: first component: second component: the 3rd component: the 4th component=1: 0.01～0.06: 0.01～0.06: 0.01～0.06: 0.01～0.06.
The method for making of above-mentioned skin moistening burn and scald ointment is characterized in that the processing procedure of described first component medicine and/or extract is: medicine is in 5～40 ℃ dosage vegetable oil, and behind immersion 12～48h, lixiviating solution is standby.
The method for making of above-mentioned skin moistening burn and scald ointment, the processing procedure that it is characterized in that described second component medicine and/or extract is: in the dosage vegetable oil of medicine prior to 100～200 ℃, after soaking 5～20min, continue to heat up, keep 5～20min in 150～300 ℃ again, filter, lixiviating solution is standby, and medicinal residues discard.
The method for making of above-mentioned skin moistening burn and scald ointment, the processing procedure that it is characterized in that described the 3rd component medicine and/or extract is: medicine is under 150～300 ℃, and wax (cured) matter is incorporated in the vegetable oil of dosage after-filtration to be melted together, lixiviating solution is standby, and medicinal residues discard.
The method for making of above-mentioned skin moistening burn and scald ointment is characterized in that the processing procedure of described the 4th component medicine and/or extract is: under 30～70 ℃, in the substrate that adds first to the 3rd component medicine, add the medicine of the 4th component, stir.
The method for making of above-mentioned skin moistening burn and scald ointment is characterized in that in described the 4th component medicine, and Mirabilitum crystallina needs elder generation after 600～800 ℃ of calcination, grinds to be fine powder.
The method for making of above-mentioned skin moistening burn and scald ointment is characterized in that in described the 4th component medicine, and succinum need grind earlier and is fine powder.
The present invention is the guidance according to motherland's theory of medicine, the length of fused various treatment burn and scald medicines, it not exclusively is conceived to infection, also be not limited to heat-clearing and toxic substances removing one method, but from integral viewpoint, use to comprise Therapeutic Method such as removing heat from blood, hemostasis, detoxifcation, putrefaction removing, granulation promoting, various exopathogenic factors are brought out, hide in the pyretic toxicity of intramuscular, by dark and shallow going out clearly.
Prove that through the clinical practice more than 3 years the Paste for burns and scalds according to the inventive method is made has heat-clearing and toxic substances removing, putrefaction-removing granulation-promoting, anti-inflammatory analgesic, skin care, patient's no pain in the treatment is cured fast and effects such as preventing from scar.
Cure rate has reached purpose of the present invention satisfactorily up to 98.9%.
According to the Paste for burns and scalds that the inventive method is made, trade name " skin-moistening burn and scald peace " is characterized in:
1. fast; Be that treatment cycle is short.
2. letter; Processing procedure is easy.
3. economize; Because short treating period, medical expense is economized.
Through clinical 126 example checkings, to burn and scald I, II patient, major part stopped to ooze out in two days, incrustation after three days, and crust was come off to central authorities by the edge in five～seven days, and after crust took off to the greatest extent, newborn skin moisturizing was smooth, preventing from scar.Wound face is healed the time entirely, according to the wound depth difference, the shortest five days (even three days, the I degree), the longest 16 days (III degree).To III degree burn and scald wound face, need as the case may be, increase, subtract dressing change frequency, curative effect is also satisfied.
Method provided by the invention prepared " skin-moistening burn and scald peace " also has two big characteristics, that is:
When (1) using, only make general debridement treatment, do not require aseptic sterilization, clinical in none routine secondary infection;
(2) in the medication process, form layer protecting film (infection substrate), both blocked the passage that bacterial invasion causes infection at wound face; promoted the blood circulation of wound face again; strengthen the permeability of medicine, quickened the growth of granulation tissue and newborn skin, shortened healing time.This is because this dosage form is translucent ointment, in treatment, only needs coating skim medicine on wound face, can cover equably on whole wound face, and unidirectional vapour transmission is strong, and the penetration foot is given full play to medicine usefulness.
Owing to adopt exposure method, do not use dressing coverings such as gauze, exempted the misery that " dressing adhesion " causes to patient.
Method provided by the invention prepared " skin-moistening burn and scald peace ", once clinical extreme misery burn and scald (hot water, deep fat, steam, firecracker, the bright ferrum of being used for ...) and the burn and scald that causes of other reason, maximum 56 years old of patient age, minimum 9 months, burn and scald area minimum 3%, maximum 26%, the burn and scald degree of depth related to I, II, III degree, all obtained satisfied curative effect.
[embodiment one]
Substrate is the mixture of Oleum Ricini and paraffin wax, and its weight ratio is,
Oleum Ricini: cured matter=1: 0.03,
Medicine and/or extract are divided into four groups, wherein:
First component is Cortex Moutan and Radix Arnebiae (Radix Lithospermi);
Second component is Caulis Spatholobi and Radix Et Rhizoma Rhei;
The 3rd component is an Olibanum;
The 4th component is Borneolum Syntheticum and succinum; Its weight ratio is,
Substrate: first component: second component: the 3rd component: the 4th component=1: 0.01: 0.06: 0.06: 0.01.
The processing procedure of described first component medicine and/or extract is: medicine is in 5～10 ℃ dosage vegetable oil, and behind the immersion 48h, lixiviating solution is standby.
The processing procedure of described second component medicine and/or extract is: in the dosage vegetable oil of medicine prior to 100～150 ℃, behind the immersion 20min, continue to heat up, in 250～300 ℃ of maintenance 5min, filter, lixiviating solution is standby, and medicinal residues discard.
The processing procedure of described the 3rd component medicine and/or extract is: medicine under 250～300 ℃ and cured matter be incorporated in together in the vegetable oil of dosage, after-filtration to be melted, lixiviating solution is standby, medicinal residues discard.
The processing procedure of described the 4th component medicine and/or extract is: under 50～70 ℃, in the substrate that adds first to the 3rd component medicine, add the medicine of the 4th component, stir.
In described the 4th component medicine, succinum need grind in advance and be fine powder.Preserve in airtight, frescade, standby.During use, behind the surgical debridement, can apply " skin-moistening burn and scald peace " routinely.
[embodiment two]
Substrate is the mixture of Oleum Arachidis hypogaeae semen and paraffin wax, and its weight ratio is,
Oleum sesami: cured matter=1: 0.05,
Medicine and/or extract are divided into four groups, wherein:
First component is Radix Angelicae Sinensis and Radix Arnebiae (Radix Lithospermi);
Second component is Cortex Phellodendri and Radix Et Rhizoma Rhei;
The 3rd component is a Myrrha;
The 4th component is Borneolum Syntheticum and succinum; Its weight ratio is,
Substrate: first component: second component: the 3rd component: the 4th component=1: 0.06: 0.01: 0.01: 0.06.
The processing procedure of described first component medicine and/or extract is: medicine is in 10～20 ℃ dosage vegetable oil, and behind the immersion 36h, lixiviating solution is standby.
The processing procedure of described second component medicine and/or extract is: in the dosage vegetable oil of medicine prior to 150～200 ℃, behind the immersion 5min, continue to heat up, in 200～250 ℃ of maintenance 8min, filter, lixiviating solution is standby, and medicinal residues discard.
The processing procedure of described the 3rd component medicine and/or extract is: medicine under 150～200 ℃ and cured matter be incorporated in together in the vegetable oil of dosage, after-filtration to be melted, lixiviating solution is standby, medicinal residues discard.
The processing procedure of described the 4th component medicine and/or extract is: under 30～50 ℃, in the substrate that adds first to the 3rd component medicine, add the medicine of the 4th component, stir.
In described the 4th component medicine, succinum need grind earlier and be fine powder.Storage, using method are with embodiment one.
[embodiment three]
Substrate is the mixture of Oleum sesami and Cera Flava, and its weight ratio is,
Oleum sesami: waxiness=1: 0.08,
Medicine and/or extract are divided into four groups, wherein:
First component is the Radix Angelicae Dahuricae, Cortex Moutan and Radix Arnebiae (Radix Lithospermi);
Second component is Cortex Phellodendri, Rhizoma Coptidis and Radix Et Rhizoma Rhei;
The 3rd component is a Sanguis Draxonis;
The 4th component is Borneolum Syntheticum and Mirabilitum crystallina; Its weight ratio is,
Substrate: first component: second component: the 3rd component: the 4th component=1: 0.03: 0.02: 0.02: 0.04.
The processing procedure of described first component medicine and/or extract is: medicine is in 20～30 ℃ dosage vegetable oil, and behind the immersion 24h, lixiviating solution is standby.
The processing procedure of described second component medicine and/or extract is: in the dosage vegetable oil of medicine prior to 140～180 ℃, behind the immersion 15min, continue to heat up, in 180～250 ℃ of maintenance 10～15min, filter, lixiviating solution is standby, and medicinal residues discard.
The processing procedure of described the 3rd component medicine and/or extract is: medicine under 200～250 ℃ and cured matter be incorporated in together in the vegetable oil of dosage, after-filtration to be melted, lixiviating solution is standby, medicinal residues discard.
The processing procedure of described the 4th component medicine and/or extract is: under 40～60 ℃, in the substrate that adds first to the 3rd component medicine, add the medicine of the 4th component, stir.
In described the 4th component medicine, Mirabilitum crystallina needs elder generation after 600～800 ℃ of calcination, grinds to be fine powder.Storage, using method are with embodiment one.
[embodiment four]
Substrate is the mixture of Oleum Camelliae and Cera Flava, and its weight ratio is,
Oleum Camelliae: waxiness=1: 0.12,
Medicine and/or extract are divided into four groups, wherein:
First component is Radix Angelicae Sinensis, Radix Sanguisorbae and Radix Arnebiae (Radix Lithospermi);
Second component is Rhizoma Coptidis, Cortex Phellodendri and Radix Et Rhizoma Rhei;
The 3rd component is a Sanguis Draxonis;
The 4th component is Moschus and Mirabilitum crystallina; Its weight ratio is,
Substrate: first component: second component: the 3rd component: the 4th component=1: 0.05: 0.04: 0.03: 0.05.
The processing procedure of described first component medicine and/or extract is: medicine is in 30～40 ℃ dosage vegetable oil, and behind the immersion 12h, lixiviating solution is standby.
The processing procedure of described second component medicine and/or extract is: in the dosage vegetable oil of medicine prior to 140～180 ℃, behind the immersion 10min, continue to heat up, in 180～280 ℃ of maintenance 10～15min, filter, lixiviating solution is standby, and medicinal residues discard.
The processing procedure of described the 3rd component medicine and/or extract is: medicine under 200～280 ℃ and waxiness be incorporated in together in the vegetable oil of dosage, after-filtration to be melted, lixiviating solution is standby, medicinal residues discard.
The processing procedure of described the 4th component medicine and/or extract is: under 30～60 ℃, in the substrate that adds first to the 3rd component medicine, add the medicine of the 4th component, stir.
In described the 4th component medicine, Mirabilitum crystallina needs elder generation after 600～800 ℃ of calcination, grinds to be fine powder.Storage, using method is the same.
Claims (6)
1, a kind of autofrettage that belongs to the skin-moistening burn and scald medicine of ointment category, this skin-moistening burn and scald medicine is made by substrate and compatibility of drugs,
Feature of the present invention is:
(1) described substrate is the mixture that vegetable oil and cured (wax) matter are formed, and its weight ratio is vegetable oil: cured (wax) matter=1:0.03～0.12,
(2) described vegetable oil can be to select in the middle of Oleum Ricini, Oleum Arachidis hypogaeae semen, Oleum sesami or Oleum Camelliae etc.,
(3) described cured (wax) matter can be to select in the middle of paraffin wax, Cera Flava or spermaceti etc.,
(4) described medicine can be medicine and/or its extract, is divided into four groups, wherein:
First component is to choose 2～3 kinds wantonly from Cortex Moutan, Radix Angelicae Sinensis, Radix Sanguisorbae, the Radix Angelicae Dahuricae and Radix Arnebiae (Radix Lithospermi),
Second component is to choose 2～3 kinds wantonly from Caulis Spatholobi, Cortex Phellodendri, Rhizoma Coptidis and Radix Et Rhizoma Rhei,
The 3rd component is to choose 1～2 kind wantonly from Olibanum, Myrrha and Sanguis Draxonis,
The 4th component is from Moschus, Borneolum Syntheticum, succinum and Mirabilitum crystallina optional 1～2 kind, and its weight ratio is,
Substrate: first component: second component: the 3rd component: the 4th component=1: 0.01～0.06: 0.01～0.06: 0.01～0.06: 0.01～0.06.
2, according to the autofrettage of the described skin-moistening burn and scald medicine of claim 1, it is characterized in that the processing procedure of described first component medicine and/or extract is: medicine is in 5～40 ℃ dosage vegetable oil, and behind immersion 12～48h, lixiviating solution is standby.
3, according to the autofrettage of the described skin-moistening burn and scald medicine of claim 1, the processing procedure that it is characterized in that described second component medicine and/or extract is: in the dosage vegetable oil of medicine prior to 100～200 ℃, after soaking 5～20min, continue to heat up, keep 5～20min in 150～300 ℃ again, filter, lixiviating solution is standby, and medicinal residues discard.
4, according to the method for making of the described Paste for burns and scalds of claim 1, the processing procedure that it is characterized in that described the 3rd component medicine and/or extract is: medicine is under 150～300 ℃, and wax (cured) matter is incorporated in the vegetable oil of dosage together, after-filtration to be melted, lixiviating solution is standby, and medicinal residues discard.
5, according to the method for making of the described Paste for burns and scalds of claim 1, the processing procedure that it is characterized in that described the 4th component medicine and/or extract is: under 30～70 ℃, in the substrate that adds first to the 3rd component medicine, add the medicine of the 4th component, stir.
6, according to the method for making of the described Paste for burns and scalds of claim 5, it is characterized in that in described the 4th component medicine that Mirabilitum crystallina needs earlier after 600～800 ℃ of calcination, grind and be fine powder.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 91106369 CN1055297A (en) | 1991-03-28 | 1991-03-28 | A kind of autofrettage of skin-moistening burn and scald medicine |
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| CN 91106369 CN1055297A (en) | 1991-03-28 | 1991-03-28 | A kind of autofrettage of skin-moistening burn and scald medicine |
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Cited By (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1045061C (en) * | 1993-06-15 | 1999-09-15 | 温兰如 | Burn and scald drug |
| CN1054069C (en) * | 1996-08-21 | 2000-07-05 | 曾占林 | Preparation of external-use ointment for burn and scald |
| CN1056281C (en) * | 1993-12-31 | 2000-09-13 | 刘永录 | Medicine for treating burn and its preparing process |
| CN1058397C (en) * | 1994-09-16 | 2000-11-15 | 天津市中医药科技开发神农公司 | Wound sticker and its peparing method |
| CN1903282B (en) * | 2006-08-16 | 2010-06-02 | 李美 | Ointement for treating frostbite and its prepration method |
| CN1899441B (en) * | 2006-06-28 | 2010-08-04 | 广东皮宝制药股份有限公司 | Chinese medicine paste for burn and its preparing method |
| CN101401889B (en) * | 2008-06-06 | 2010-12-22 | 通化昌源医药科技有限公司 | External use medicament capable of effectively relieving scar sufferings, softening and removing scar |
| CN101559125B (en) * | 2008-04-14 | 2011-04-20 | 胡继明 | Burning powder |
| CN102028765A (en) * | 2010-12-28 | 2011-04-27 | 射洪冲鸣抗菌制剂有限公司 | Burn and scratch treating liquid and preparation method thereof |
| CN1806827B (en) * | 2005-01-19 | 2011-06-29 | 北京凯瑞创新医药科技有限公司 | Chinese medicinal composition, its preparation process and quality control method |
| CN102205019A (en) * | 2011-05-16 | 2011-10-05 | 郭新潮 | Moisture burn ointment capable of relieving toxicity and preparation method thereof |
| CN102258746A (en) * | 2011-06-29 | 2011-11-30 | 李宏干 | Ointment for treating surface of burns and scalds |
| CN102370804A (en) * | 2010-08-19 | 2012-03-14 | 徐铮 | Quick-acting burn and scald emulsifiable concentrate |
| CN102698019A (en) * | 2012-06-21 | 2012-10-03 | 李春华 | Traditional Chinese medicine composition for curing burning and preparation method of same |
| CN102697889A (en) * | 2012-05-25 | 2012-10-03 | 李惠斌 | Pasting oiled silk dressing for treating burn and preparation method and application thereof |
| CN102836242A (en) * | 2012-09-28 | 2012-12-26 | 保枢平 | External medicament for treating scalds and burns |
| CN103127342A (en) * | 2013-01-30 | 2013-06-05 | 吴殿信 | Ointment capable of curing scald and preparation method thereof |
| CN103191307A (en) * | 2013-04-11 | 2013-07-10 | 宋奇仓 | Herbal ointment for treating cauterization and scald and preparation method of herbal ointment |
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| CN109908241A (en) * | 2018-12-29 | 2019-06-21 | 中国人民解放军总医院 | Botanical composition for treating water and gas scald burns |
| CN110433236A (en) * | 2019-07-23 | 2019-11-12 | 哈尔滨医科大学 | A kind of Chinese medicine composition and its preparation method and application promoting wound healing |
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1991
- 1991-03-28 CN CN 91106369 patent/CN1055297A/en active Pending
Cited By (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1045061C (en) * | 1993-06-15 | 1999-09-15 | 温兰如 | Burn and scald drug |
| CN1056281C (en) * | 1993-12-31 | 2000-09-13 | 刘永录 | Medicine for treating burn and its preparing process |
| CN1058397C (en) * | 1994-09-16 | 2000-11-15 | 天津市中医药科技开发神农公司 | Wound sticker and its peparing method |
| CN1054069C (en) * | 1996-08-21 | 2000-07-05 | 曾占林 | Preparation of external-use ointment for burn and scald |
| CN1806827B (en) * | 2005-01-19 | 2011-06-29 | 北京凯瑞创新医药科技有限公司 | Chinese medicinal composition, its preparation process and quality control method |
| CN1899441B (en) * | 2006-06-28 | 2010-08-04 | 广东皮宝制药股份有限公司 | Chinese medicine paste for burn and its preparing method |
| CN1903282B (en) * | 2006-08-16 | 2010-06-02 | 李美 | Ointement for treating frostbite and its prepration method |
| CN101559125B (en) * | 2008-04-14 | 2011-04-20 | 胡继明 | Burning powder |
| CN101401889B (en) * | 2008-06-06 | 2010-12-22 | 通化昌源医药科技有限公司 | External use medicament capable of effectively relieving scar sufferings, softening and removing scar |
| CN102370804A (en) * | 2010-08-19 | 2012-03-14 | 徐铮 | Quick-acting burn and scald emulsifiable concentrate |
| CN102028765A (en) * | 2010-12-28 | 2011-04-27 | 射洪冲鸣抗菌制剂有限公司 | Burn and scratch treating liquid and preparation method thereof |
| CN102205019A (en) * | 2011-05-16 | 2011-10-05 | 郭新潮 | Moisture burn ointment capable of relieving toxicity and preparation method thereof |
| CN102205019B (en) * | 2011-05-16 | 2013-03-06 | 郭新潮 | Moisture burn ointment capable of relieving toxicity and preparation method thereof |
| CN102258746B (en) * | 2011-06-29 | 2012-12-26 | 李宏干 | Ointment for treating surface of burns and scalds |
| CN102258746A (en) * | 2011-06-29 | 2011-11-30 | 李宏干 | Ointment for treating surface of burns and scalds |
| CN102697889A (en) * | 2012-05-25 | 2012-10-03 | 李惠斌 | Pasting oiled silk dressing for treating burn and preparation method and application thereof |
| CN102698019A (en) * | 2012-06-21 | 2012-10-03 | 李春华 | Traditional Chinese medicine composition for curing burning and preparation method of same |
| CN102836242A (en) * | 2012-09-28 | 2012-12-26 | 保枢平 | External medicament for treating scalds and burns |
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