CN105496412B - A kind of expiration inflammation monitoring method and device - Google Patents
A kind of expiration inflammation monitoring method and device Download PDFInfo
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- CN105496412B CN105496412B CN201510881093.8A CN201510881093A CN105496412B CN 105496412 B CN105496412 B CN 105496412B CN 201510881093 A CN201510881093 A CN 201510881093A CN 105496412 B CN105496412 B CN 105496412B
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- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
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Abstract
The present invention introduces a kind of expiration inflammation monitoring method, and subject uses the normal tidal breath of expiration inflammation patient monitor, and a part of the breathing gas in collection process, wherein expiration CO2 is horizontal for measurement, and shows on the display module in real time；Air-flow is directed into gas chamber when detecting that the expiration CO2 level reaches preset range；Aforesaid operations are repeated within the multiple respiratory cycle, until the airflow volume for importing gas chamber is more than one times or more of gas chamber volume；According to the inflammation gas molecule of required measurement, selects air-flow in the type of flow of analysis gas circuit and the gas concentration sensor flowed through, measure the Gas Molecular Density in gas chamber；According to the respiratory rate recorded, actual concentration of the gas molecule in moisture expiration is calculated；According to the tidal volume of subject, equilibrium concentration of the gas molecule in alveolar is calculated.
Description
Technical field
The present invention relates to characteristics of contaminated respiratory droplets gas monitoring arts.
Background technique
The measurement of different kinds of molecules concentration can assist diagnosis patient disease in characteristics of contaminated respiratory droplets gas, monitoring disease states and
Observe therapeutic effect etc., exhaled NO and CO(eNO and eCO) it can be used as the research that marker of inflammation is worth Intensive Care Therapy, this
It is to be generated since endogenous gas signaling molecule NO and CO is decomposed by cortex cell arginine deamination and ferroheme respectively,
The pro-inflammatory cytokines such as infection, allergy, wound can be by increasing inductivity NO synzyme (iNOS) and Heme oxygenase (HO1)
It expresses and NO and CO concentration is caused to significantly rise, and can be quantitative determined by expired air analysis.And it temporarily can be with there is no technology
It realizes during carrying out Respiratory Care to severe, operation, measurement is synchronized to the concentration of exhaled NO and CO.
Existing Respiratory Care technology includes: partial pressure of carbon dioxide in endexpiratory gas (pETCO2) monitoring, anesthetic gases monitoring etc..
The monitoring of partial pressure of carbon dioxide in endexpiratory gas (pETCO2) is described in patent CN201510038742, it passes through in measurement breathing
CO2 partial pressure level curve judges pulmonary ventilation and blood flow variation, but there is no divide the inflammatory molecule NO and CO in expiration
Analysis test；Patent CN201080049377 describes the patient monitor of anesthetic gases, and the instrument is for monitoring sucking and exhaled gas
The concentration of middle arcotic, for instructing the implementation of anesthesia and improving anesthesia safety, also not to the inflammatory molecule NO in expiration
Analysis test is carried out with CO.
And the existing instrument guarded to airway inflammation has Aerocrine, MINO, VERO series of Inc.
(US20040082872) and still a coulomb breath analyzing instrument series of receiving for medical electronics is irrigated.The product of wherein Aerocrine, Inc.
Mainly for detection of NO molecular concentration in expiration, coulomb breath analyzing instrument of receiving can detect NO and CO molecular concentration in expiration respectively.
And two kinds of technologies expiration inflammatory molecule detected, all expiration state is required, eNO is required with the flow of 50ml/s at least
Breathe out 10s(children 6s), eCO requires to feel suffocated and slowly exhale to expiration end after 15s, is not used to breathing anesthesia Intensive Care Therapy etc.
Expiration monitoring arts.
Restrict this two instrument for Respiratory Care field technical factor mainly since the period of tidal breath is shorter,
When simple acquisition exhaled gas is measured, there are two problems: 1) it is dense to will affect collected expiratory air molecule for respiratory rate
Degree measurement；2) molecular concentration can not directly react the molecular concentration in steady state alveolar gas in expiratory air.
So if a kind of expiration inflammation monitoring method or device can be provided, monitoring patient respiratory state simultaneously,
The gas at the position (air flue or alveolar) significant to clinic diagnosis is acquired, and certain Gas Molecular Densities therein are divided
Analysis measurement, this undoubtedly has great significance for expiration monitoring arts such as breathing anesthesia Intensive Care Therapies.
Summary of the invention
A technical problem to be solved by this invention is to provide a kind of expiration inflammation monitor device, in exhaling for monitoring patient
Suction state simultaneously, acquires the gas at the position (air flue or alveolar) significant to clinic diagnosis, and to certain gases therein point
Sub- concentration carries out analysis measurement.
Another technical problem to be solved by this invention is to determine the exhaled gas molecular concentration come to examine with to clinic
The conversion between physiology Gas Molecular Density for breaking significant.
In order to solve above-mentioned two technical problem, the present invention provides a kind of expiration inflammation monitoring methods: making in subject
When tidal breath normal with expiration inflammation patient monitor, a part of the breathing gas in collection process measures wherein expiration CO2 water
It is flat, and show on the display module in real time；Air-flow is directed into gas chamber when detecting that expiration CO2 level reaches preset range；
Aforesaid operations are repeated within the multiple respiratory cycle, until the airflow volume for importing gas chamber is more than one times or more of gas chamber volume；Root
According to the inflammation gas molecule of required measurement, select air-flow in the type of flow of analysis gas circuit and the gas concentration sensing flowed through
Device measures the Gas Molecular Density in gas chamber；According to the respiratory rate recorded, the gas molecule is calculated in moisture expiration
Actual concentration；According to the tidal volume of subject, equilibrium concentration of the gas molecule in alveolar is calculated.
The above method for acquire end-tidal or alveolar air when, before acquisition, allow subject's eupnea practice several times, to
Respiratory curve steadily acquires the gas for meeting the preset range of expiration CO2 level afterwards, and the preset range of the expiration CO2 level is logical
Cross at the same meet following two condition determine, 1) n-th breathing in, expiration CO2 level >=end-tidal threshold value, 2) expiration CO2 water
Flat derivative is positive value.
The end-tidal threshold value is determining by following condition, threshold value=n-th predicted value-B of n-th, n-th predicted value
=A* the N-1 times highest CO2 level+(1-A) * the N-1 times predicted value, wherein when the 1st predicted value=practice most
High CO2 level-B, wherein A, B are constant.
When the above method is used to acquire expiration front end or air flue gas, expiration CO2 level is greater than B and is less than end-tidal threshold value, and
The derivative of expiration CO2 level is positive value.
The Gas Molecular Density directly tested pass through the respiratory rate demarcated in advance and concentration relationship curve amendment to this
Actual concentration of the gas molecule in moisture expiration.
In tidal breath, exhaled gas molecular concentration can reflect steady state alveolar gas concentration formula after correcting by formula
Are as follows: exhalation concentrations/steady state alveolar gas concentration=a*ln expired volume-b, a, b is constant.
In order to realize above-mentioned expiration inflammation monitoring method, the present invention also provides a kind of expiration inflammation monitor devices, by controlling
Molding block (100), functional module (200) and display module (300) are constituted, and functional module includes at least monitoring, sampling, analysis function
Can, the triple valve one (201) being connected with carbon dioxide module (202) front end carries out empty for switching air end and subject end
Gas zero point correction or Respiratory Care；The triple valve two (203) being connected with carbon dioxide module (202) rear end for switch atmosphere and
Gas chamber (204), the expiration CO2 measured according to carbon dioxide module (202) is horizontal and preset condition, the gas being analysed to import
Gas chamber, ineligible gas drain into outside device；The triple valve three (206) being connected with analysis pump (207) front end is for switching
The gas that gas chamber (204) comes out passes through or not by filter one (205), the triple valve four being connected with analysis pump (207) rear end
(208) it is returned to gas chamber (204) for switching gas by one in two paths, an access is concatenated wetting balance device
(209) and gas concentration sensor one (210), another access are concatenated gas concentration sensor two (211), filter
(212), functional module is integrally in circulation pattern.
The display module (300) is LED screen, TFT screen or connect with computer that it is bent that the information of display includes at least breathing CO2
Line, real-time expiration CO2 is horizontal, the concentration of respiratory rate and at least one gas molecule, and the display module (300) includes abnormal
The sound and light of curve alarm and prompt.
The gas concentration sensor is these hydrogen sulfide gas sensor, CO gas sensor, hydrogen gas sensor
Or nitric oxide gas sensor.
The control module (100) includes central processing module, power module, mobile power source module and printer module.
As seen from the above technical solution provided by the invention, expiration inflammation monitoring method and dress of the present invention
Set, it may be convenient to the respiratory state of patient is guarded, and monitoring while exhale to it in various gas molecules it is dense
Degree is measured, and by the utilization of various algorithms, has modified influence of the respiratory rate to measurement result, while can also reflect
Molecular concentration in steady state alveolar gas.Technical solution provided by the invention surveys Respiratory Care, expiration sampling and expiration molecule
Surely it is integrated in one, improves the reliability of sampling and test.
Detailed description of the invention
A kind of expiration inflammation monitor device of Fig. 1.
Expiration CO2 level curve and end-tidal preset condition curve when Fig. 2 tidal breath.
Under Fig. 3 difference respiratory rate, when testing known concentration CO, the test value accuracy by amendment front and back compares.
Specific embodiment
The following are expiration inflammation monitoring method and device of the invention is utilized, to breathing during subject's tidal breath
CO2 level is guarded, and a specific reality of measurement end-tidal CO concentration is acquired and analyzed to wherein end-tidal CO gas
Apply mode.
Subject uses the expiration inflammation monitor device such as Fig. 1, and tidal breath is adopted with the pumping pump discharge of 100ml/min
A part of gas in collection expiratory air enters CO2 module, measures its CO2 water Ventilation, surveyed CO2 level is met pre-
If the gas importing gas chamber of condition, outside ungratified discharge system.Fig. 2 is its tidal breath expiration CO2 level curve and expiration
The curve of last preset condition, wherein the computational constant a of threshold value takes 0.2, B to take 3mmHg, and the respiratory rate of the subject is 16bpm,
Moisture exhaled gas twice of gas chamber volume (total volume be) in about 45 periods of repeated acquisition.
Flow direction of the gas in analysis is gas chamber 204, triple valve 206, analysis pump 207, triple valve 208, gas concentration biography
Sensor 211, filter 212, wherein gas concentration sensor 211 is electrochemical carbon monoxide sensor, and filter 212 is an oxygen
Change carbon filter.The tidal breath CO concentration that the subject directly tests is 1.2ppm, according to the respiratory rate 16bpm recorded
Its true tidal breath CO concentration is obtained after amendment, and it is tested at this to converse CO molecule further according to its tidal volume 450ml for 1.5ppm
Equilibrium concentration in person's alveolar is 2.6ppm.It (feels suffocated after subject's depth air-breathing with the method for detecting alveolar CO concentration in standard
Then 15s slowly breathes out gas, acquire last expiratory air and carry out CO concentration analysis) it compares, the two result is consistent,
Specifically relatively it see the table below.
Fig. 3 is under different respiratory rates, when testing known concentration CO, by the test value accuracy ratio of amendment front and back
Compared with, it can be seen from the figure that respiratory rate is faster, test value is relatively low bigger, but by amendment after, accuracy can ± 10% it
It is interior.
Claims (9)
1. a kind of expiration inflammation monitoring method, it is characterised in that: subject uses expiration inflammation monitor device, and normal moisture is exhaled
It inhales, acquires a part of the breathing gas in respiratory, and measure the CO that wherein exhales2Level, and in real time on the display module
It has been shown that, as the expiration CO detected2Air-flow is directed into gas chamber when level reaches preset range；It is repeated within the multiple respiratory cycle
Operation, until the airflow volume for importing gas chamber is more than one times or more of gas chamber volume；
According to the inflammation gas molecule of required measurement, select air-flow in the type of flow of analysis gas circuit and the gas concentration flowed through
Sensor measures the Gas Molecular Density in gas chamber；According to the CO of record2Horizontal available respiratory rate, and then calculate
Actual concentration of the gas molecule in moisture expiration；According to the tidal volume of subject, the gas molecule is calculated in alveolar
Css；
When for acquiring end-tidal or alveolar air, before acquisition, subject's eupnea is allowed to practice several times, it is steady to respiratory curve
Acquisition meets expiration CO afterwards2The gas of horizontal preset range, expiration CO2Horizontal preset range passes through while meeting following two
A condition determines, 1) in n-th breathing, expiration CO2Level >=end-tidal threshold value, 2) expiration CO2Horizontal derivative is positive value；
End-tidal threshold value is determining by following condition, threshold value=n-th predicted value-B of n-th, n-th predicted value=A*
The N-1 times highest CO2Level+(1- A) * the N-1 times predicted value, wherein highest CO when the 1st predicted value=practice2
Level-B, A, B are constant.
2. expiration inflammation monitoring method as described in claim 1, it is characterised in that: for acquiring expiration front end or air flue gas
When, the expiration CO2Horizontal preset range are as follows: 1) B≤expiration CO2Horizontal < end-tidal threshold value, 2) expiration CO2Horizontal leads
Number is positive value.
3. expiration inflammation monitoring method as described in claim 1, it is characterised in that: the Gas Molecular Density directly tested passes through
Actual concentration of the respiratory rate and concentration relationship curve amendment demarcated in advance to the gas molecule in moisture expiration.
4. expiration inflammation monitoring method as described in claim 1, it is characterised in that: when tidal breath, exhaled gas molecule is dense
Degree can reflect steady state alveolar gas concentration formula after correcting by formula are as follows:, a, b are constant.
5. a kind of expiration inflammation monitoring method as described in claim 1, it is characterised in that: the expiration inflammation monitor device used by
Control module (100), functional module (200) and display module (300) are constituted；Functional module includes at least monitoring, sampling, analysis
Function, the triple valve one (201) being connected with carbon dioxide module (202) front end are carried out for switching air end and subject end
Air zero point correction or Respiratory Care；The triple valve two (203) being connected with carbon dioxide module (202) rear end is for switching atmosphere
With gas chamber (204), the expiration CO measured according to carbon dioxide module (202)2Horizontal and preset condition, the gas being analysed to are led
Air inlet chamber, ineligible gas drain into outside device；The triple valve three (206) being connected with analysis pump (207) front end is for cutting
The gas that air-exchanging chamber (204) comes out passes through or not by filter one (205), the triple valve being connected with analysis pump (207) rear end
Four (208) are used to switch gas and are returned to gas chamber (204) by one in two paths, and an access is concatenated wetting balance
Device (209) and gas concentration sensor one (210), another access are concatenated gas concentration sensor two (211), filter
(212), functional module is integrally in circulation pattern.
6. expiration inflammation monitoring method as claimed in claim 5, it is characterised in that: the display module (300) be LED screen or
TFT screen, the information of display include at least breathing CO2Curve, real-time CO2Level, respiratory rate and at least one gas molecule it is dense
Degree.
7. expiration inflammation monitoring method as claimed in claim 5, it is characterised in that: the display module (300) and computer connect
It connects, the information of display includes at least breathing CO2Curve, real-time CO2Level, the concentration of respiratory rate and at least one gas molecule.
8. expiration inflammation monitoring method as claimed in claim 5, it is characterised in that: the gas concentration sensor is hydrogen sulfide
Gas sensor, CO gas sensor, hydrogen gas sensor or nitric oxide gas sensor.
9. expiration inflammation monitoring method as claimed in claim 5, it is characterised in that: the control module (100) includes center
Processing module, power module and printer module.
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| CN201510881093.8A CN105496412B (en) | 2015-12-04 | 2015-12-04 | A kind of expiration inflammation monitoring method and device |
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| CN201510881093.8A CN105496412B (en) | 2015-12-04 | 2015-12-04 | A kind of expiration inflammation monitoring method and device |
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| CN105496412B true CN105496412B (en) | 2019-04-19 |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106770738B (en) * | 2016-12-03 | 2024-02-20 | 浙江大学 | Expired gas multicomponent detector with corrected carbon dioxide concentration and detection method |
| CN110441351A (en) * | 2019-07-15 | 2019-11-12 | 河北雄安绿研检验认证有限公司 | A kind of expiratory air VOCs detection device and application for the continuous self-appraisal of human health |
| CN113069102A (en) * | 2020-01-06 | 2021-07-06 | 深圳市先亚生物科技有限公司 | Breath collection system and method |
| CN111407280B (en) * | 2020-03-10 | 2022-04-15 | 山东大学 | End-tidal CO of noninvasive ventilator2Monitoring device and method |
| CN112782371A (en) * | 2021-01-29 | 2021-05-11 | 惠雨恩科技(深圳)有限公司 | Gas concentration detection device |
| CN113777244A (en) * | 2021-09-27 | 2021-12-10 | 惠雨恩科技(深圳)有限公司 | Alveolar gas concentration detection device and method for separating air passage |
| CN114814103A (en) * | 2022-04-28 | 2022-07-29 | 青岛华仁医疗用品有限公司 | Off-line exhaled gas nitric oxide detection device |
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| CN102065763A (en) * | 2008-05-28 | 2011-05-18 | 尼图尔医疗有限公司 | Method and apparatus for CO2 evaluation |
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