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CN105456517A - Traditional Chinese medicinal composition and preparation for treating chronic hepatitis B and preparation method of preparation - Google Patents

Traditional Chinese medicinal composition and preparation for treating chronic hepatitis B and preparation method of preparation Download PDF

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CN105456517A
CN105456517A CN201510937182.XA CN201510937182A CN105456517A CN 105456517 A CN105456517 A CN 105456517A CN 201510937182 A CN201510937182 A CN 201510937182A CN 105456517 A CN105456517 A CN 105456517A
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radix
parts
preparation
liver
chronic hepatitis
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彭国能
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention relates to a traditional Chinese medicinal composition and a preparation for treating chronic hepatitis B and a preparation method of the preparation. The preparation is prepared from herba artemisiae scopariae, raw radix astragali, poria cocos, roasted bighead atractylodes rhizome, radix salviae miltiorrhizae, Chinese angelica root, radix paeoniae alba, radix paeoniae rubra, glossy privet fruit, endothelium corneum gigeriae galli, fruit of Chinese wolfberry and safflower carthamus through various preparation processes. The traditional Chinese medicinal composition disclosed by the invention has functions of protecting liver, recovering liver functions, promoting the repair of damaged liver tissues, protecting the liver and reducing enzyme, and resisting hepatic fibrosis, and the traditional Chinese medicinal composition has a good curative effect on treating the chronic hepatitis B. Observed by clinical and pharmacological experiments, the traditional Chinese medicinal composition is free from toxic and side effects, and the traditional Chinese medicinal composition has popularization and application prospects.

Description

A kind of Chinese medicine composition of Treatment chronic Hepatitis B, preparation and preparation method
Technical field
The invention belongs to technical field of Chinese medicines, be a kind of traditional Chinese medicine technology for the treatment of chronic hepatitis, refer to a kind of Chinese medicine composition of Treatment chronic Hepatitis B, preparation and preparation method especially.
Background technology
Its worldwide disease of one mainly caused by hepatitis B virus (HBV) of hepatitis B.Wherein, chronic hepatitis B is the most common clinically, and chronic hepatitis B is modal one in China's infectious disease, one of public health problem that the Ye Shi world is the most serious.Wherein most of patient is in hepatitis B virus chronic carrier state, and annual nearly hundreds of thousands people dies from hepatitis B and various complication thereof.Hepatitis B is that a kind of pathogenesis is intricate, sickness rate is high, the course of disease is long, refractory is healed, easy disease repeatedly, and the later stage even can cause liver cirrhosis and hepatocarcinoma, finally causes death.Its Therapeutic Method is more and more subject to concern and the attention of all circles, but there is no satisfied treatment means so far, traditional western medicine poor effect, and relapse rate is higher, and Chinese medicine is to treating hepatitis B there being its distinctive advantage.
The current treatment status of hepatitis B: in recent years, whole world hepatitis b virus carrier reaches more than 400,000,000 people, the patient dying from HBV infection and relevant complication thereof is every year countless, and China is the high Prevalent district of hepatitis B, its number of patients reaches more than 30,000,000 people, and prevalence and fatality rate are all higher.Though the extensive popularization and application of vaccination, reduces neonatal sickness rate to a certain extent, based on the population base of compatriots, hepatitis B is still one of subject matter that annoying infectious disease medical science, is also one of following serious health problem.
The therapeutic purposes of hepatitis B, mainly suppressed the breeding of HBV to copy before obviously damage occurs liver.The generally early stage suppression first carrying out virus replication, then further consider removing virus.At present for the Therapeutic Method of hepatitis B, comprise the treatment such as antiviral agents, immunomodulating, cytokine, fibrosis, ribozyme to be effectively defined as in blood and to remove lastingly, when infection transfers integration period to by replicative phase, common final result alleviates but not cures, interferon and lamivudine be at present unique approval for medicine.Current China is antiviral treatment and interferon therapy mainly, and clinically main or to the west of medical treatment be main, antiviral therapy application is wherein comparatively extensive, wherein main medicine has interferon (interferon, IFN-oL), Peg-IFN alpha-2b (PegIFN) and nucleoside (acid) similar medicine are as adefovirdipivoxil (adefo-vir, ADV), lamivudine (1amivudineLAM), Sebivo (telbi.vudineLDT) and for Nuo Fuwei (tenofovirTDF) etc., undoubtedly, these medicines all can obviously control copying of hepatitis B virus, postpone progression of disease, extend the survival of patients time, thus improve the quality of living, but these antiviral drugs all can not effectively remove HBVDNA virus, so it is in the cards hardly for realizing the long-term target removing HBV.And, also there is the antiviral therapy of quite a few patient to fail to play Expected Results.
Often be used at present to treat hepatitis B Western medicine one of them, for masses what be familiar with is interferon, although tool the liver protecting cell or promote the effect that liver cell is repaired, there is no the effect of directly suppression hepatitis B virus or booster immunization.Therefore, though can improve the liver function of part inactivity chronic hepatitis B patient, for active chronic hepatitis B, its therapeutic effect is quite limited.Interferon has the effect of facedown toxin and booster immunization, and long-term injection can improve the probability that activeness hepatitis B is converted to inactivity hepatitis B, tends towards stability to make the state of an illness.But due to some side effect during injection, and must injection competence exertion maximum efficiency under machine in due course, must enforcement side be therefore safe and reliable under the careful assessment of doctor.Another antiviral oral drugs Lamivudine, its antivirus action makes activeness hepatitis B change the success rate of inactivity hepatitis B into not second to interferon, and rare obvious side effect, is the medicine hves great potential.But easily have Drug resistance after this medicine long-term taking, and withdrawal is easily sent out again, even have the phenomenon of deterioration.
The traditional Chinese medical science is to the discussion of the etiology and pathogenesis of hepatitis B:
Since doctor trained in Western medicine has found hepatitis B virus and made important progress in its treatment, middle medical circles have also initiatively started the exploration to hepatitis B virus character.Current most of researcher all thinks that hepatitis B virus is a kind of epidemic disease caused by damp-heat pathogen poison, and HBV is main or propagated by body fluid, thus belongs to typical exopathogen, and has certain susceptibility.
Traditional Chinese medical science scholar thinks that this disease is that toxic dampness and heat accumulates in middle burnt taste, fumigate caused by the liver and gall, and virus is also hidden in human body blood system, blood of being allowed for access after sick heat of wetting gradually, gas same stage.
Chinese medicine, in the control of hepatitis B, except having the effects such as the liver protecting and ALT lowering, having gained public acceptance for reverse Early hepatic fibrosis, for improving symptom and quality of life, having extended life cycle with the obvious advantage especially.Western modern medicine therapy can not meet the needs of patient, and Chinese medicine hepatitis B has advantage and the method for its uniqueness, and has vast potential for future development.
Chinese medicine hepatitis B has himself advantage, the several aspect of major embodiment:
1, the effect of many target position, comprises and improves symptom, liver function, the immunologic function of adjustment patient, blocks and reverses hepatic fibrosis and suppress copying of hepatitis B virus.Therefore Chinese medicine can have certain effect.
2, doctor trained in Western medicine thinks unsuitable or the hepatitis B patient of Endodontic failure, and as the virus carrier of immune tolerance, antiviral agents Endodontic failure person or Severe Hepatitis, Decompensated Cirrhosis Patients etc., adopt Chinese medicine to receive certain effect.
3, side effect is relatively less, patient compliance and toleration better.
4, medical expense is relatively low.The many kinds of measures of the correct understanding combination of Chinese and Western medicine treats the specific medicament killing hepatitis B virus of also not generally acknowledging so far, but by the many kinds of measures treatment of the combination of Chinese and Western medicine such as anti-hepatitis B virus, immunomodulating, hepatoprotective, copying of hepatitis B virus can be suppressed.
Chinese medicine has larger potentiality in Treatment chronic Hepatitis B, in long-term clinical treatment, Chinese medicine decoction Treatment chronic Hepatitis B good effect, but carry inconvenience, patient is difficult to adhere to taking, in view of the above circumstances, constantly finding for many years and a kind ofly absorb fast, onset rapidly and allow patient easily adhere to the dosage form taken, has been the direction that this area is urgently studied.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition of Treatment chronic Hepatitis B, be good for clear hot malicious ﹑ profit wet ﹑ benefit gas of separating the compound Chinese medicinal preparation that spleen ﹑ blood stasis of blood ﹑ alive supplementing QI and nourishing YIN is base therapy method Treatment chronic Hepatitis B.
The present invention is achieved by the following technical solutions:
A Chinese medicine composition for Treatment chronic Hepatitis B, its raw material is made up of capillary wormwood, the Radix Astragali, Poria, Bai Intraoperative, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Paeoniae Rubra, Fructus Ligustri Lucidi, Endothelium Corneum Gigeriae Galli, Fructus Lycii and Flos Carthami.
Further, the described Rhizoma Atractylodis Macrocephalae is Rhizoma Atractylodis Macrocephalae (parched); The described Radix Astragali is Radix Astragali; Described when being classified as Radix Angelicae Sinensis.
Further, the Chinese medicine composition of described Treatment chronic Hepatitis B, its raw materials by weight portion proportioning is: capillary wormwood 8-23 part, Radix Astragali 10-30 part, Poria 6-30 part, Bai Intraoperative 6-30 part, Radix Salviae Miltiorrhizae 10-30 part, Radix Angelicae Sinensis 6-30 part, Radix Paeoniae Alba 10-30 part, Radix Paeoniae Rubra 6-30 part, Fructus Ligustri Lucidi 8-23 part, Endothelium Corneum Gigeriae Galli 6-22 part, Fructus Lycii 6-22 part and Flos Carthami 6-22 part.
Further, the Chinese medicine composition of described Treatment chronic Hepatitis B, its raw materials by weight portion proportioning is preferably: capillary wormwood 10-16 part, Radix Astragali 15-25 part, Poria 10-23 part, Bai Intraoperative 10-23 part, Radix Salviae Miltiorrhizae 15-25 part, Radix Angelicae Sinensis 10-23 part, Radix Paeoniae Alba 15-25 part, Radix Paeoniae Rubra 10-23 part, Fructus Ligustri Lucidi 10-16 part, Endothelium Corneum Gigeriae Galli 8-15 part, Fructus Lycii 8-15 part and Flos Carthami 8-15 part.
Further, the Chinese medicine composition of described Treatment chronic Hepatitis B, its raw materials by weight portion proportioning is more preferably: capillary wormwood 12 parts, the Radix Astragali 20 parts, Poria 15 parts of, Bai Intraoperative 15 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Angelicae Sinensis 15 parts, the Radix Paeoniae Alba 20 parts, Radix Paeoniae Rubra 20 parts, Fructus Ligustri Lucidi 12 parts, Endothelium Corneum Gigeriae Galli 10 parts, Fructus Lycii 10 parts and 10 parts, Flos Carthami.
A Chinese medicine preparation for Treatment chronic Hepatitis B, adopt above-mentioned any one Chinese medicine constituent, it makes the medicament of the dosage form on any one pharmaceutics; Or after adding adjuvant, make the medicament of the dosage form on any one pharmaceutics.
A Chinese medicine preparation for Treatment chronic Hepatitis B, adopt above-mentioned any one Chinese medicine constituent, the medicament of the dosage form on any one pharmaceutics made by its extractant; Or the medicament of the dosage form on any one pharmaceutics made by extractant after adding adjuvant.
Described medicament is pill, powder, tablet, unguentum, water preparation, injection, oral liquid, granule or capsule.
Treat a preparation method for the Chinese medicine preparation of chronic hepatitis, comprise the following steps:
Radix Angelicae Sinensis, Radix Paeoniae Rubra and the Radix Paeoniae Alba are ground into fine powder, mix after spraying into ethanol, sealing, then oven dry obtains fine powder for subsequent use;
Add water capillary wormwood and the Rhizoma Atractylodis Macrocephalae distillating extracting oil, collects described volatile oil, described volatile oil water extraction, obtains refined volatile oil, extracts rear solution and medicinal residues;
Decoction liquor is obtained after described medicinal residues, Poria, the Radix Astragali, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, Fructus Lycii, Flos Carthami and Endothelium Corneum Gigeriae Galli being decocted with water;
Thick paste is concentrated into after merging described decoction liquor and described extraction rear solution; Described thick paste is mixed with described fine powder for subsequent use, through super-dry, sieve after obtain sieve upper part and lower part of screen divide; Described lower part of screen is divided after spraying into described refined volatile oil and mix, then mix with described oversize, obtain compound preparation.
Further, described soak by water decocts for three times totally, and wherein decocting time is identical with second time decocting time for the first time, but is greater than third time decocting time; Decoct the decoction liquor mixing obtained for three times.
The invention has the beneficial effects as follows:
Technical scheme of the present invention is based on the theory of motherland's medical science to " hypochondriac pain ", " epidemic disease poison ", " jaundice ", " gathering " and " asthenia " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.The QI and blood of liver, follows passages through which vital energy circulates and goes in left and right two side of body, " Ling Shu Miraculous Pivot or Divine Axis passages through which vital energy circulates " carries " the liver meridian of Foot-JUE YIN ... holding stomach under the arm belongs to liver network gallbladder, above passes through diaphragm, cloth side of body rib ... ".Therefore liver is ill, comprise the stagnation of QI, blood stasis, occupy-place, tumor, cause the passages through which vital energy circulates QI and blood catharsis of liver, and regulate the network road of QI and blood to be obstructed, actually obstructed many dragging pain, alter pain, severe pain, attack pain, distending pain, twinge, void is not flourish many dull pain, painful abdominal mass pain then, tight use and cloud: " liver was both hindered, and pneumatosis attacks note, to attack in a left side then pain in the left hypochondrium; to attack in the right side then pain in the right hypochondrium, move inverse two and coerce then pain in the hypochondrium.The hepatopathy later stage forms " tympanites ", " Plain Questions. the most pure virginity will be discussed greatly " say: " all damp-edema are full, all belong to spleen.From clinically, hepatopathy must undermine spleen kidney, occurs that the swollen gastral cavity of rib is vexed, the diseases such as nausea and vomiting or abdominal distention loose stool.Chronic hepatitis patient heat in blood impairment of YIN, cloudy anemia is damaged, so that liver body inactivation.The liver belonging to wood, liver body loses foster with the passing of time withered hardening, and this is the most important pathogenesis that chronic hepatitis B causes liver cirrhosis.And heat in blood impairment of YIN, in blood, then blood retrogradation is stagnant for YIN-fluid being insufficient, stagnant then inactivation, and this is also the pathogenesis that blood stasis occurs hepatitis gradually.Blood poisoning heat is combined with blood stasis again, malicious stasis of blood knot, is to form the pathogenesis that hepatocarcinoma dislikes disease.
With reference to modern pharmacological research achievement, have employed the method for Qing Re Xie Du ﹑ Li Shi ﹑ Yi gas Jian Pi ﹑ Huo blood Yu ﹑ supplementing QI and nourishing YIN, scientific compatibility, filters out following compound recipe.Prescription for monarch drug, antiinflammatory, improves the effect of Liver Microcirculation and anti-hepatic fibrosis, soft liver eliminating stagnation with (life) Radix Astragali, the Radix Paeoniae Alba, Radix Salviae Miltiorrhizae Yiqi-Huoxue-Huayu, reduces portal vein pressure, prevents hepatic fibrosis pathological changes from continuing development.Be aided with and (fry) Bai Intraoperative, Radix Angelicae Sinensis, Poria, Radix Paeoniae Rubra is ministerial drug, strengthen effect of hepatic cholagogic, blood circulation promoting and blood stasis dispelling.Capillary wormwood, Endothelium Corneum Gigeriae Galli clearing heat and expelling damp, invigorating the spleen and regulating the stomach are adjuvant, alleviate swelling of liver cell, strengthen the function of detoxification of liver.Make, with Fructus Ligustri Lucidi, Flos Carthami, Fructus Lycii spleen reinforcing nourishing the stomach, to promote hepatocellular new life
Chronic hepatitis b disease feelings anti-Fu ﹑ protracted course of disease, reuses in side and controls blood medicine 1. and can suppress proliferation of fibrous tissue, can suppress allergy; 2. be conducive to the retraction of hepatosplenomegaly; 3. invigorate blood circulation and get final product the Eradicates stasis of blood, the Eradicates stasis of blood gets final product tissue regeneration promoting, can be conducive to liver cell regeneration.Full side runs through the method for Qing Re Xie Du ﹑ Li Shi ﹑ Yi gas Jian Pi ﹑ Huo blood Yu ﹑ supplementing QI and nourishing YIN, accelerates to worsen to prevent the state of an illness.
Detailed description of the invention
Describe technical scheme of the present invention in detail by the following examples, following embodiment is only exemplary, only can be used for explaining and technical scheme of the present invention being described, and can not be interpreted as being the restriction to technical solution of the present invention.
In the medicine of Treatment chronic Hepatitis B of the present invention, with Radix Angelicae Sinensis, the promoting the circulation of blood of Radix Astragali benefiting qi and nourishing blood and non-blood trouble, lose greatly for QI and blood and the patient that has the stasis of blood stagnant, the pharmacological research of the present, the Radix Astragali has the function recovered each cells of organs and regenerate.
Radix Paeoniae Alba sour in the mouth, directly enters liver, has nourishing liver-YIN, adjusts irritability, suppressing the hyperactive liver sun, the effect of relieving spasm to stop pain.
Essentials of Matea Medica: " enrich blood, eliminating pathogen in the liver, strengthening the spleen, holds back liver-yin." for the deficiency of YIN-blood of the course of disease with the passing of time liver, the liver failing to be nourished, thus time have side of body rib dull pain or do not relax.The Radix Paeoniae Alba is the root of cohosh Radix Paeoniae, and have the effect of Yang Xue ﹑ Zhi Bi ﹑ Yi Qi ﹑ dredging collateral, Radix Paeoniae Alba total glucosides is the effective ingredient extracted from the Radix Paeoniae Alba.Modern pharmacology proves, TGP has the Kang Yan ﹑ Mian epidemic disease Tiao Jie ﹑ Zhen Jing ﹑ Zhen Tong ﹑ Yang of Nai Que ﹑ antioxidation and Kang Xin Ji Que Xue ﹑ and the effect such as to protect the liver.
Radix Paeoniae Rubra energy Qing Re Xie Du ﹑ Liang blood Huo Xue ﹑ blood stasis dispelling jaundice eliminating.Radix Paeoniae Rubra nature and flavor picric acid is slightly cold, Ru Gan ﹑ spleen two warp, as Compendium of Material Medica is said: " stagnant in the promoting the circulation of blood of Radix Paeoniae Rubra San Xie ﹑ energy ".Radix Paeoniae Rubra has multiple effects such as improving blood viscid Du ﹑ minimizing Hong Xi born of the same parents Ju Ji ﹑ enhancing liver blood flow Liang ﹑ protection hepatocyte and adjustment blood plasma cylic nucleotide.Therefore liver blood circulation can not only be improved with Radix Paeoniae Rubra, recover liver function, and have choleretic effect, make jaundice prompt resolution.
The damp eliminating of capillary wormwood energy Qing Re Xie Du ﹑ diuretic, can promote bile secretion and excretion, alleviate hepar damnification, also has the multiple pharmacologically actives such as Xie Re ﹑ Zhen Tong ﹑ Kang Yan ﹑ antitumor in addition.
Radix Salviae Miltiorrhizae simply, the same SIWU TANG of merit, can support the Hang ﹑ of Neng and to invigorate blood circulation jaundice eliminating.Modern pharmacological research confirms; Enzyme falls in Radix Salviae Miltiorrhizae energy hepatoprotective, soft contracting liver spleen, improves immunity.Radix Salviae Miltiorrhizae can improve microcirculation, strengthen liver blood flow amount, promote that hepatocyte is repaired and regeneration, research find danshensu in vivo external enwergy suppress the cytokines such as LPS (lipopolysaccharide) leukocyte TNF secretion-α ﹑ IL-6 ﹑ IL-1 that stimulates, improve the survival rate of endotoxin challenge mice.
Flos Carthami blood circulation promoting and blood stasis dispelling, relatively QI and blood regulating, because " qi being the governor of blood ", " the capable then blood of gas ", " stagnation of QI is stasis then ".The blood vessels of the unobstructed liver of Flos Carthami, can improve the circulation of portal vein regulating liver-QI inner blood, prevent in blood capillary solidifying, promote that fibrinolytic function reduces position ischemic state, increase liver blood flow amount, enrich hepatocyte nutrition and activating liver cell, accelerate the effects such as the reparation of focus.
Chao Bai Intraoperative, Poria, tonifying the spleen fortune is wet, and improve the edema abdominal distention of insufficiency of the spleen leading to overabundance of dampness, lack of appetite is had loose bowels, to embody the principle of " seeing the disease of liver, knowing the liver disease will be transmitted into the spleen, in the ban tonifying the spleen ".Chao Bai Intraoperative has the merit of spleen invigorating, diuretic, detumescence.Pharmacological research, confirmed that Bai Intraoperative had increase albumin, corrected albumin and globulin modern age, and had and show lasting diuresis, can promote again the discharge of sodium.Take a broad view of the pharmacological action of Bai Intraoperative, meet the Therapeutic Principle of modern medicine to cirrhotic ascites; Poria has promoting diuresis to eliminate damp pathogen, the merit of spleen-benefiting mind-tranquilizing.Amplification on Canon of Materia Medica: " merit of the capable water of this thing is many, heart-spleen boosting can not fault also." modern age pharmacological research, confirm Poria tool diuresis, to increase in urinating the electrolytical discharges such as potassium, sodium, chlorine.
With the passing of time ill, undermine kidney of lower warmer through person, to get the method for the middle part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, then select Fructus Ligustri Lucidi, Fructus Lycii, Endothelium Corneum Gigeriae Galli nourishing the liver and kidney, invigorating the spleen and regulating the stomach, QI and blood regulating, with consolidate curative effect.
Compound Chinese medicinal preparation each raw material function of Treatment chronic Hepatitis B of the present invention cures mainly as follows:
One, capillary wormwood
This product is the dry aerial parts of feverfew Artemisia scoparia Waldst. et Kit. ArtemisiascopariaWaldst.etKit. or Herba Artemisiae Scopariae ArtemisiacapillarisThunb..Gather during the high 6 ~ 10cm of seedling in spring or autumn, alabastrum grew up to time tap, removing impurity and old stem, dry.The habit of gathering spring claims " capillary wormwood ", the title " Herba Artemisiae Scopariae " tapped autumn.Bitter in the mouth, pungent, cold nature.Return spleen, stomach, liver, gallbladder meridian.There is clearing away damp-heat, effect of jaundice eliminating subcutaneous ulcer.For jaundice oliguria, eczema pruritus; Infectious jaundice type hepatitis.This product is containing 6,7-Dimethylesculetin (6,7-dimethylsculetin) and volatile oil, a-pinene, capillin (capillin) capillen block (capillene), capillanol (capillanol), capillarisin (capillarisin), chlorogenic acid etc. are mainly in oil.
Pharmacological action:
Choleretic effect
Herba Artemisiae Scopariae is containing the effective ingredient escoparone of tool choleretic effect.Herba Artemisiae Scopariae decoct, Herba Artemisiae Scopariae Fructus Gardeniae decoct, Herba Artemisiae Scopariae Decoction (Herba Artemisiae Scopariae, Fructus Gardeniae, Radix Et Rhizoma Rhei are with 3:1.5:1) and alcohol extract thereof all have the effect promoting rat bile secretion, but it is obvious not, Herba Artemisiae Scopariae decoct only shows the gallbladder contraction (x-ray inspection) of normal person and slightly reduces, and volume changes not remarkable.Infusion and the refining concentrated immersion (two kinds that remove and do not remove volatile oil) of Herba Artemisiae Scopariae all have obvious choleretic effect to acute gallbladder intubate and chronic gallbladder fistula dog, infer that its effective ingredient may be water and alcohol soluble substance, the effect of volatilization sleeve is then suspicious or more weak; But also have report, from the Herba Artemisiae Scopariae of Nanjing, isolated volatile oil, has choleretic effect to Cavia porcellus.Isolated 6,7-dimethoxy coumarins from the alabastrum of Herba Artemisiae Scopariae and HUANGSONG, duodenal administration, all can make anesthesia rat, the bile secretion of ductus choledochus intubate and chronic gallbladder fistula dog increases.The chlorogenic acid (water-soluble organic acid) proposed from Herba Artemisiae Scopariae seedling is to the rat of ductus choledochus intubate, after intravenous injection, namely about there is choleretic effect in half an hour, its log10 dose and bile secretion increase percentage rate and to be in line relation, and the hydrolysate caffeic acid of chlorogenic acid also has choleretic effect.Herba Artemisiae Scopariae Decoction and Herba Artemisiae Scopariae extractum, can make the hemobilirubin of the rabbit of ligation biliary pore reduce (because the impact of caused hepatocellular degeneration of performing the operation is only secondary).
On the impact of experimental hepatitis
Herba Artemisiae Scopariae Decoction, Herba Artemisiae Scopariae and Fructus Gardeniae, Rhubarb concoction all can reduce the mortality rate of white mice carbon tetrachloride poisoning hepatitis, the infusion of Herba Artemisiae Scopariae and refining concentrated immersion, comparatively remarkable to normal dogs to its choleretic effect of dog of carbon tetrachloride poisoning hepatitis, Herba Artemisiae Scopariae decoct and Herba Artemisiae Scopariae volatile oil on the serum transaminase of carbon tetrachloride poisoning hepatitis rabbit without impact, but the latter can make hepatitis rabbit appetite increase, to the white mice of viral hepatitis without the effect improving its mortality rate and liver cell lesion.Herba Artemisiae Scopariae Decoction decoct has promotion liver cell regeneration effect to rabbit.
Two, the Radix Astragali
This product is the dry root of leguminous plant Radix Astagali Astragalusmembranaceus (Fisch.) Bge.var.mongholicus (Bge.) Hsiao or Radix Astragali Astragalusmembranaceus (Fisch.) Bge..Spring, Qiu Erji excavate, and removing fibrous root and root head, dry.Sweet in the mouth, warm in nature.Return lung, spleen channel.There is invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.Radix Astragali root is containing 2 ', 4 ' dihydroxy-5,6-dimethoxy isoflavone (2 ', 4 '-dihydroxy-5,6-dimethoxyisoflavone), the folic acid of choline (choline), betanin (betaine), aminoacid, sucrose, glucuronic acid and trace.Astragalus mongholicus Bge root is containing cupreol, linoleic acid and linolenic acid.
Pharmacological action:
To the effect of taste
The Radix Astragali can improve the gastrointestinal propulsive effect function of spleen-deficient IBS rat model, increases rat preduodenal maximum shrinkage force and minimum Diastolic Force, shrinkage amplitude is reduced, frequency deceleration.The Radix Astragali has regulating action to rat stomach intestinal motive force is abnormal.Astragalus polysaccharides injectable powder (APS-P) can promote the recovery of mouse immune system function after chemotherapy effectively, the ability of BALB/c mouse splenocyte secrete cytokines after increase chemotherapy, there is certain regulating action to normal mouse secrete cytokines, and the kill capability of S-180 tumor-bearing mice NK cell can be promoted.Astragalus polysaccharides (100 μ g/ml) can cause mouse spleen lymphocyte Protein kinase C (PKC) activity obviously to raise, and the immunological enhancement of prompting APS is relevant with rising splenocyte protein kinase activity.Astragalus polysaccharides causes bone marrow depression mice to have to ametycin (MMC) and promotes the propagation of bone marrow and spleen and ripe effect.The damage of the Radix Astragali to spleen has reparation and short regeneration.The Radix Astragali 95% ethanol extraction has stronger anti-ulcer effect compared with its opposed polarity extract part, relevant with the Multiple components contained by it with drug effect correlation analysis known Radix Astragali anti-ulcer effect by HPLC finger printing.For gastric precancerous lesion patient, Astragalus in Treating is evident in efficacy, and relapse rate is low, and clinic is extensively promoted.The mechanism of action of Astragalus in Treating gastric ulcer may be the expression by promoting EGF, EGFR, makes the repair and reconstruction preferably of gastric epithelial tissue, gland structure, thus promotes ulcer healing and improve Ulcer cicatrization quality.
To the effect of liver and gall
The Radix Astragali has effect of anti hepatic fibrosis, and its mechanism may be relevant with regulating patient TGF-β 1, IFN-γ content.The Radix Astragali has protective effect to hepatic ischemia-reperfusion injury in rats, and during Ischemia-reperfusion Injury in Rat, hepatic sinusoidal endothelial cells ICAM-1 developed by molecule increases, and mediating neutrophil may be the basis of Ischemia-reperfusion Injury in Rat in localized clusters, activation thus.The Radix Astragali can suppress the adhesion of neutrophilic granulocyte and endotheliocyte, suppresses the gathering of neutrophilic granulocyte, activation, thus alleviates hepatic ischemia-reperfusion injury.The Radix Astragali obviously can improve liver cirrhosis patient liver protein synthesis function and corresponding clinical symptoms.
Three, Poria
This product is the dry sclerotia of On Polyporaceae Poria Poriacocos (Schw.) Wolf.Excavate more than 7 ~ JIUYUE, dig out rear removing silt, bank up after " diaphoresis ", spread out and dry in the air to dry tack free, then " diaphoresis ", after extremely now scatter and disappear in wrinkle, the large portion of internal moisture for several times repeatedly, dry in the shade, be called " Poria "; Or fresh Poria is pressed different parts cutting, dry in the shade, be called " Cortex Sclerotii Poriae " and " Poria block ".Sweet in the mouth, light, property is put down.GUIXIN, lung, spleen, kidney channel.There is promoting diuresis to eliminate damp pathogen, effect of spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.Sclerotium accounts for dry weight 93% and triterpenoid compound Pachymic acid, pachymic acid, 3 beta-hydroxy Pilus Caprae seu Ovis steroid trienic acids containing β-pachyman.In addition, still gummy, chitin, protein, fat, sterol, lecithin, glucose, adenine, histidine, choline, β-pachyman catabolic enzyme, lipase, protease etc.
Pharmacological action:
On the impact of digestive system
Poria has significant protective effect to Liver Damage in Rats caused by CCl4, gpt activity is obviously reduced, prevents hepatic necrosis.Carboxymethyl pachyman has good curative effect to liver cirrhosis, chronic persistent hepatitis, the patient of 90% takes rear liver function and improves, to the recent cure rate of acute icterohepatitisshock more than 30%, the content of serum complement C3 and IgA can be improved, reduce the content of IgG and IgM.Poria immersion has direct relexation to rabbit excised tea fresh leaves, and myenteron contractive amplitude is reduced, and tension force declines, and has preventive and therapeutic effect, and can lower gastric acid secretion, be usually used in weakness of the spleen and stomach, dyspepsia, anorexia and loose stool person clinically to rat Experimental oral ulcer.Experiment proves, the vomiting that fuling triterpene and derivant thereof can suppress the oral copper sulfate of the frog to cause.Fuling triterpene compound makes the DIA of insulin strengthen, and triterpenoid itself also has DIA.
Hepatoprotective effect
Adopt carbon tetrachloride, high fat low protein diet, the complex disease such as to drink copies hepatitis interstitialis chronica animal model because stimulating, after hepatitis interstitialis chronica is formed, through Poria alcohol treatment three weeks, result shows that control animals still has hepatitis interstitialis chronica, and administration treated animal hepatitis interstitialis chronica obviously alleviates, in liver, collagen content is lower than matched group, and urinary hydroxyproline output is higher than matched group, show that medicine can promote experimental cirrhosis animal livers collagen degradation, fibrous tissue in liver is heavily absorbed.Experimental liver cirrhosis is formed under the complex diseases such as Carbon tetrachloride, high fat low protein diet are because of effect, through cirrhosis treatment 3 weeks, result shows, medicine can alleviate laboratory animal hepatic fibroplasia degree, reduce collagen content in liver, increase urinary hydroxyproline to discharge, show that cirrhosis can promote that collagen degradation and liver fiber heavily absorb.Result also shows cirrhosis can alleviate the degeneration of acute liver damage animal liver cell, necrosis, reduces serum glutamic pyruvic transminase active.It is active that fuling triterpene significantly can reduce AST, ALT in mice serum.Pathological section clearly illustrates that fuling triterpene significantly can alleviate the degree of mouse liver injury.Fuling triterpene has obvious therapeutic action to the mouse liver injury caused by CCl4.Carboxymethyl pachyman (Carboxymethylpachymaran; CMP) there is hepatoprotective effect; CMP has good protective effect to hepatic fibrosis rats model hepatic tissue cell, and expressing TGF-13 and have obvious inhibitory action, may be one of main mechanism of its anti-hepatic fibrosis.CMP has obvious inhibitory action to hepatic fibrosis rats model hepatic tissue cell TGF-β expression, can lower the expression of Smad3, raise the expression of Smad7, having good regulating action to TGF-β-Smad system, may be one of main mechanism of its anti-hepatic fibrosis.
Four, Rhizoma Atractylodis Macrocephalae (parched)
This product is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae AtractylodesmacrocephalaKoidz..Excavate when withered and yellow, the upper leaf of inferior leads in winter becomes fragile, removing silt, dries or dries, then remove fibrous root.Rhizoma Atractylodis Macrocephalae (parched) is sprinkled in hot pot by processed with honey wheat bran, adds Rhizoma Atractylodis Macrocephalae sheet in time smoldering, and fry to coke yellow, effusion burnt odor gas, take out, sieve removes processed with honey wheat bran.Every 100kg Rhizoma Atractylodis Macrocephalae sheet, with processed with honey wheat bran 10kg.Bitter in the mouth, sweet, warm in nature.Return spleen, stomach warp.There is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.Containing volatile oil 1.4%, main component is atractylol, atractylone etc., and containing vitamin A.
Pharmacological action:
To the effect of gastrointestinal smooth muscle
The impact of the Rhizoma Atractylodis Macrocephalae on isolated small intestines of rabbits spontaneous activity is how not identical, it is movable that the Rhizoma Atractylodis Macrocephalae can strengthen Isolated rabbit intestine Spontaneous Contraction, its shrinkage amplitude is strengthened, and Rhizoma Atractylodis Macrocephalae oil suppresses the autonomic movement of intestinal tube, or the autonomic movement impact of the Rhizoma Atractylodis Macrocephalae on isolated small intestines of rabbits is not obvious.The Rhizoma Atractylodis Macrocephalae has obvious antagonism to the isolated small intestines of rabbits tetanic contraction caused by acetylcholine, dichloride barium, and to the suppression of the isolated rabbit small intestinal activity added caused by epinephrine, the Rhizoma Atractylodis Macrocephalae can this effect of antagonism.But also there is report there is no obvious antagonism.(crude drug/kg obviously can promote the synthesis of Protein in small intestine to continuously mouse stomach to Rhizoma Atractylodis Macrocephalae decoct 10g every day.Rhizoma Atractylodis Macrocephalae extract 50mg and 200mg/kg gastric infusion, to animal water-immersion restraint stress ulcer, have and show inhibition.
Liver-protecting and blood fat-reducing effect
Rhizoma Atractylodis Macrocephalae total extract and 100% ethanol position significantly can reduce Mice Body weight values and TC, TG, atherogenic index (AI) level.Rhizoma Atractylodis Macrocephalae total extract and 100% ethanol position all have the effect raising HDL-C level in hyperlipidemia rats serum, but only have 100% ethanol position to reduce LDL-C.Rhizoma Atractylodis Macrocephalae total extract, 100% ethanol and 50% ethanol position can the risings of antagonism ALT, AST activity, and the liver coefficient of Rhizoma Atractylodis Macrocephalae total extract group and 100% ethanol position group hyperlipidemia rats obtains significance improves.In the Rhizoma Atractylodis Macrocephalae, lipotropy natural product (100% ethanol or methanol position) has stronger effect for reducing blood fat, and Rhizoma Atractylodis Macrocephalae total extract and lipotropy natural product (100% ethanol or methanol position) have certain hepatoprotective effect.
Five, Radix Salviae Miltiorrhizae
This product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae SalviamiltiorrhizaBunge..Spring, Qiu Erji excavate, removing silt, dry.Bitter in the mouth, cold nature, GUIXIN, Liver Channel.There is stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.Containing tanshinone Ⅰ, II A, II B, Isotanshinone I., II A, cryptotanshinone, different cryptotanshinone, methyltanshinone, hydroxyl TANSHINONES etc.
Pharmacological action:
Treat unresolved, chronic hepatitis
Radix Salviae Miltiorrhizae can improve liver physiology function to unresolved and chronic hepatitis, impel the principle of liver and spleen retraction and deliquescing, may be because Radix Salviae Miltiorrhizae can expand peripheral blood vessel, reduces portal venous pressure, liver inner blood is circulated and improves, increase the supply of hepatocellular nutrition and oxygen.Radix Salviae Miltiorrhizae energy blood circulation promoting and blood stasis dispelling, to the hypertrophy eliminating hepatic fibrosis connective tissue, also may have certain effect.Radix Salviae Miltiorrhizae can make liver regeneration degree, mitosis figures index, AFP recall rate all increase, and illustrates that Radix Salviae Miltiorrhizae has the effect promoting liver regeneration.As for its mechanism of action, may to improve sanguimotor effect relevant with Radix Salviae Miltiorrhizae.On the basis that whole body and local organization blood circulation improve, Portal Blood Flow being increased, improves liver blood supply and nutrition, may be the key factor promoting liver regeneration.Liver regeneration is subject to the adjustment of multiple hormone, and especially insulin and glucagon have the effect obviously promoting liver regeneration, and Radix Salviae Miltiorrhizae improves blood circulation can bring more insulin and glucagon, in promotion liver regeneration, also may have certain effect.
Treatment advanced schistosomiasis hepatosplenomegaly
Radix Salviae Miltiorrhizae change that is little to hepatosplenomegaly and character has suitable effect.27 routine hepatomegaly patients, after controlling, 12 examples reduce, 15 routine deliquescing, and 12 examples are without changing; Splenomegaly 41 example, the person of reducing 20 example after treatment, deliquescing person 22 example, without changer 19 example.Wherein large with third group of consumption and first group elder's course for the treatment of curative effect is comparatively remarkable, generally take effect after 10 ~ 15 days in treatment.But all case ends see that liver spleen narrows down to normal person.This product is like shorter to stadium, and the state of an illness comparatively the lighter is easy to take effect.As coordinated rational diet and rest, curative effect must be improved.The toxicity of Radix Salviae Miltiorrhizae is extremely low, once dosage is increased to every day 45 grams, and is used in conjunction 83 days, also without adverse consequences.But there is 1 routine dosage and little (every day 30 grams), with the upper gastrointestinal hemorrhage that namely occurrence cause was not clear to the 9th day; Therefore think all and have vomiting, have blood in stool, spit blood, hematuria, the bleeding tendency person such as purpura avoid and use Radix Salviae Miltiorrhizae.
Treatment stomach, colon polyposis
Salvia Miltiorrhiza Injection stomach, colon polyposis 1 example, obtains better effects.Because patient can not row surgical operation therapy, it is Radix Salviae Miltiorrhizae Injection on probation.Start each administration 10 milliliters, add 50% Glucose Liquid 40ml intravenous injection; Reactionless after treatment for several times, be use each 20ml instead to add 50% Glucose Liquid 40ml intravenous injection.Equal every day 1 time, first course for the treatment of 35 times.Control patient's spirit, appetite in journey to take a turn for the better gradually, bloody purulent stool alleviates, and muscle power is also by force cumulative, and cardiac murmur is clearly better, and edema disappears.Stop medicine January, row second course for the treatment of, row x-ray radiography check after inject 18 times, the large portion disappearance of stomach polyp.
Six, Radix Angelicae Sinensis
This product is the dry root of umbelliferae angelica Angelicasinensis (Oliv.) Diels.Autumn end excavates, and removing fibrous root and silt, after moisture slightly evaporates, be bundled into wisp, upper canopy, with pyrotechnics slowly smoke-dried beancurd.Sweet in the mouth, pungent, warm in nature.Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.Root is containing volatile oil, and volatilization main body of oil has: butylidenephthalide, the positive pentanone of adjacent carboxyl benzene and Δ 2,4-dihydro acid phthalic anhydride.
Pharmacological action:
Hepatoprotective effect
Radix Angelicae Sinensis has protective effect to the hepatic injury that white mice acute carbon tetrachloride poisoning causes.The rats'liver glycogen that Radix Angelicae Sinensis injection can prevent D-Gal from causing reduces, energy Cell protection ATP enzyme, G-6-Pase, the activity of 5-nucleotidase.To intact animal, Radix Angelicae Sinensis does not affect liver glycogen content, does not affect the utilization of liver to glucose yet, but its endogenous can be made to breathe enhancing.To liver cell nuclear infringement caused by D-Gal, there is certain protective effect to rat ip25% Radix Angelicae Sinensis injection (10ml/kg body weight); tissue slice is observed; the liver cell nuclear of Radix Angelicae Sinensis group is in the same size; except decimal liver cell nuclear is slight abnormity; most of liver cell nuclear form is normal; saline group and vitamin C group then cause liver cell nuclear infringement because D-Gal suppresses the synthesis of RNA; visible liver cell nuclear is not of uniform size; height heteromorphism; kernel is thick in high electron density, chromatin margination.Prompting Radix Angelicae Sinensis has certain effect to protection hepatocyte and some function of recovery liver.In addition, research also shows, Radix Angelicae Sinensis has chronic liver damage and necessarily alleviates fibrosis and promote hepatocyte function restitution.The effect of certain promotion liver regeneration is had to experimental lobectomy of liver.And have experimental hepatocellular carcinoma in rats effect caused by antagonism aflatoxin B1.Angelicin (SF is the effective monomer component that Radix Angelicae Sinensis water-soluble portion extracts) has protective effect to AP and CCl4 hepatic injury, and its anti-hepatic injury mechanism is relevant with anti-lipid peroxidation.Angelicin by inducing the enzymatic activity relevant with AP metabolism, the function of detoxification of enhancing body, thus promotes that AP biology in vivo transforms and removing toxic substances.In addition, the membrane stabilizing action that SF has contributes to alleviating the operation of MDA to film.In sum, the Hepatocyte protection of angelicin may be realized by multiple approach.
Seven, the Radix Paeoniae Alba
This product is the dry root of ranunculaceae plant Radix Paeoniae PaeonialactifloraPall..Summer, Qiu Erji excavate, and clean, and remove end to end and radicula, put in boiling water after boiling rear removing crust or peeling and boil, dry.Bitter in the mouth, acid, cold nature.Return liver, spleen channel.There is suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, effect of astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.Root contains peoniflorin, paeonol, peonin, benzoic acid about 1.07%, volatile oil, fatty oil, resin, tannin, sugar, starch, phlegmatic temperament, protein, cupreol and triterpenes.
Pharmacological action:
Antiinflammatory, antiulcer action
Radix Paeoniae or peoniflorin have more weak antiinflammatory action, have inhibitory action in various degree, share synergism, also have more weak inhibitory action to abdominal cavity capillary permeability with licorice ingredient FM100 yeast, chondrus ocellatus Holmes colloidality and dextran pedal swelling.Radix Paeoniae Alba extract all has inhibitory action to rat Ovum Gallus domesticus album acute inflammation and granuloma induced by implantation of cotton pellets.Radix Paeoniae Alba total glucosides 50mg/kg, every day 1 time, continuous 11 days, has obvious inhibitory action to Rat Experimental adjuvant-induced arthritis.In Radix Paeoniae, contained paeonol, benzoylpaeoniflorin and oxypaeoniflorin also have antiinflammatory action.Peoniflorin has preventive effect to rat stress ulcer, share and suppressing there is synergism in gastric secretion, but Radix Paeoniae extracting solution makes gastric acidity slightly rise at pylorus-ligated rats and FM100.
Protect the liver antidepressant
Radix Paeoniae Alba ethanol extraction reduces the content of serum alt, AST, ALP, and in endochylema, the raising of SOD and CAT activity, MDA level reduce.Radix Paeoniae Alba ethanol extraction significantly can alleviate the acute liver injury of rats caused by CCl4, has certain protective effect.The Radix Paeoniae Alba contains the compositions such as peoniflorin, paeonol, lactone glucoside of Radix Paeoniae, benzene Shen acyl peoniflorin and has antidepressant effect.
Eight, Radix Paeoniae Rubra
This product is the dry root of ranunculaceae plant Radix Paeoniae PaeonialactifloraPall. or river Radix Paeoniae Rubra PaeoniaveitchiiLynch.Spring, Qiu Erji excavate, and removing rhizome, fibrous root and silt, dry.Bitter in the mouth, cold nature, returns Liver Channel.There is clearing away heat and cooling blood, effect of eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.
Pharmacological action:
Hepatoprotective effect
Radix Paeoniae Rubra injection 3.3mg/ml, 1.67mg/ml and 0.7mg/ml, have obvious facilitation to the DNA synthesis of Cultured Hepatocytes in vitro, have good impact to liver cell regeneration and liver function recovery.Radix Paeoniae Rubra injection 3.75g/kg intravenous injection; obvious protective effect is had to Liver Damage in Rats caused by D-galactosamine; animal dis motility rate is increased, and liver atrophy and alanine aminotransferase are starkly lower than matched group, and FN (the main opsonin of monocytes/macrophages system) is higher than matched group.The mechanism of protecting the liver may be improve the level of rat plasma bronectin (PFN), thus strengthens the phagocytic function of reticuloendothelial system and strengthen OA, to protect hepatocyte, prevents Liver immunity from damaging and promotes liver cell regeneration.Radix Paeoniae Rubra 24mg/kg lumbar injection, every day 1 time, in continuous 2 weeks, all has obvious inducing action to rat liver and heart Carboxylesterase (CEase) activity, and this effect has hydrolytic process in promotion body, promotes the effect of poisonous substance excretion in body.D-cachou extract 100mg/kg or 50mg/kg lumbar injection; protective effect is had to alcohol induced Mouse Liver mitochondrion acute injury; animal pattern hepatic mitochondria Lipid fluidity can be reduced; increase hepatic mitochondria Reductive glutathione (GSH) content; reduce Ca2+ picked-up and lipid peroxide generation; by the detoxifying function of Anti-ethanol, alleviate the acute injury of hepatic mitochondria membrane structure.
Nine, Fructus Ligustri Lucidi
This product is the dry mature fruit of Oleaceae plants Fructus Ligustri Lucidi LigustrumlucidumAit..Gather during fruit maturation in winter, removing branch and leaf, after slightly steaming or putting in boiling water and slightly scald, dry; Or convection drying.Sweet in the mouth, hardship, cool in nature.Return liver, kidney channel.There is nourishing the liver and kidney, effect of improving eyesight black hair, for vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.This product is containing nuzhenide (nuzhenide), the bitter glycosides (oleuropein) of olive, oleanolic acid (oleanolicacid), 4-hydroxyl-B-phenethyl-B-D-glucoside, betulinol (betulin) etc.
Pharmacological action:
Anti-liver injury
Oleanolic acid 30,50,100mg/kg subcutaneous injection, the rising of the rat blood serum glutamate pyruvate transaminase (SGPT) that carbon tetrachloride can be suppressed to cause, to the rat without carbon tetrachloride process, oleanolic acid 50,100mg/kg subcutaneous injection, also can make SGPT decline.Oleanolic acid 70mg/kg subcutaneous injection, can alleviate the hepatic injury that carbon tetrachloride causes, histological observation, and vacuolar degeneration of hepatic cell, loose degeneration, hepatic necrosis, lobule interstitial inflammation, all more corresponding matched group is light.An oleanolic acid 2mg/ subcutaneous injection, in continuous 6-9 week, has preventive and therapeutic effect to the function in rats with cirrhotic that high lipid food and carbon tetrachloride cause.Electron microscopic observation is to carbon tetrachloride hepatic injury rat, and an oleanolic acid 20mg/ subcutaneous injection, can make hepatocellular mitochondrial swelling and endosomal vesicle become and all alleviate.
Ten, Endothelium Corneum Gigeriae Galli
This product is the dry inner wall of sandbag of Phasianidae animal man chicken GallusgallusdomesticusBrisson.After killing chicken, take out chicken gizzard, peel inwall (first do not wash with water, otherwise difficulty being peeled off and easily fragmentation) while hot immediately, cleaning, drying.Sweet in the mouth, property is put down.Return spleen, stomach, small intestinal, urinary bladder channel.There is invigorating the stomach and promoting digestion, effect of arresting seminal emission.Do not disappear for food stagnation, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission.Endothelium Corneum Gigeriae Galli contains gastric hormone (gastric hormone ventriculin), keratin (keratin), micro-pepsin (pepsin), amylase (diastase), multivitamin.
Pharmacological action:
After the oral Endothelium Corneum Gigeriae Galli of people, gastric secretion, acidity and eupepsy are all shown in and increase, and wherein the increase of eupepsy occurs slower, maintains also more of a specified duration.After taking medicine, gastric motor function obviously strengthens, and show the prolongation of stomach moving period and the enhancing of peristalsis, due to the enhancing of stomach motion, therefore gastric emptying rate is also accelerated greatly.Endothelium Corneum Gigeriae Galli itself is not containing any digestive enzyme, and it, on the impact of stomachial secretion and motion, produces immediately after not taking medicine, and must pass through a period of time, thus its effect digested by medicine after certain humoral factor entered in blood cause.
On the impact of human stomach function
Healthy People oral Grilled chicken Endothelium corneum powder 5g, through 45-60min, gastric secretion increases 30-37% than control value, recovers normal in 2h.Gastric acidity is also obviously increased.Free acid or total acidity generally start to rise after the 1h that takes medicine, and reach peak, decline gradually later in 1-2h, recover normal after 3h.The peak of its Free Acid is 0.19-0.24%, increases 32-113% than control value; The peak of total acidity is 0.2-0.32%, increases 25-75% than normal value.Though the enhancing of eupepsy is slower, hold time more of a specified duration.Gastric motor function obviously strengthens, and show that stomach motion extends and peristalsis strengthens, therefore gastric emptying rate is accelerated.Endothelium Corneum Gigeriae Galli itself, only containing pepsin and the amylase of trace, can make the secretory volume of gastric juice increase stomach function regulating motion and strengthen after taking medicine, think it may is by caused by the neuromuscular of the excited coat of the stomach of humoral factor after Endothelium Corneum Gigeriae Galli is digested and assimilated.Also have and think that gastric hormone facilitates stomachial secretion function.
11, Fructus Lycii
This product is the dry mature fruit of plant of Solanaceae lycium barbarum LyciumbarbarumL..Summer, autumn two gather when season, fruit took on a red color, hot-air seasoning, removing carpopodium.Or dry in the air to rhicnosis, dry, removing carpopodium.Sweet in the mouth, property is put down.Return liver, kidney channel.There is nourishing the liver and kidney, effect of replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.The mature fruit of lycium barbarum contains betanin (betane), atropine (aTCMLIBopine), hyoscyamine (gyoscyamine).Again containing Semen Maydis xanthin, physalin, kryptoxanthin (cryptosxanthin), scopoletin (scopo-letin), carotene, thiamine, riboflavin, nicotinic acid, vitamin C.
Pharmacological action:
Lipotropic effect
The infusion (20%, 8ml/d gavage) of Lycium barbarum L., to the mice poisoned by carbon tetrachloride, has the slight effect suppressing fat to deposit in hepatocyte, promote hepatocyte new life.The lipotropic effect of water extract also shows, the liver dysfunction (making index with the activity of acetylcholine esterase, transaminase) preventing carbon tetrachloride from causing.As given rat longer-term (75 days) oral Fructus Lycii water extract or betanin, the phospholipid level in blood and liver can be raised; Rat after poisoning by carbon tetrachloride, in liver, phospholipid, total cholesterol content lower, and then raise to betanin or Fructus Lycii water extract to some extent in advance or simultaneously; All effect is improved to tests such as BSP, SGPT, alkali phosphatase, acetylcholine esterase simultaneously.Fructus Lycii is to lipid metabolism or lipotropic effect, and mainly caused by wherein contained betanin, the latter plays methyl supplying in vivo.
To the effect of spleen
Lycium barbarum polysaccharide (LBP) can dramatically at 5.20mg/ (kg/ days) × 7 day and increases spleen PFC number, and 5mg/kg dosage can make PFC number reach 1.4 times of normal immunological matched group.And during 25.50mg/kg, then see that PFC number obviously reduces, wherein 25mg/kg group PFC number is 43% of Normal group.Show that the reinforced effects of LBP antagonist formation cell number has suitable dosage range.LBP can dramatically at 5.20mg/ (kg/ days) × 7 day and increases spleen PFC number, and 5mg/kg dosage can make PFC number reach 1.4 times of normal immunological matched group.And during 25.50mg/kg, then see that PFC number obviously reduces, wherein 25mg/kg group PFC number is 43% of Normal group.Show that the reinforced effects of LBP antagonist formation cell number has suitable dosage range.Super appropriate SRBC immunity (SOI) is adopted to induce Ts cell method to observe, in donor mice splenocyte, Ts cell can make the PFC number of normal immunological mice suppress 63%, shows that SOI method can induce the generation of antagonist cellulation and show inhibiting Ts cell.After giving donor Mus LBP5mg/ (kg. days) × 7 day, receptor Mus PFC number shows than SOI matched group and declines, and illustrates that this dosage has potentiation to Ts cell function.When dosage be increased to 25,50mg/kg time, the potentiation of LBP to Ts cell function obviously declines.
12, Flos Carthami
This product is the dried floral of feverfew Flos Carthami CarthamustinctoriusL..Pluck when summer, flower was red by xanthochromia and get tubular flower, note the ovary of not hindering base portion, removing impurity, dry in the shade or low baking temperature oven dry, now matter is softer, the red the best of color depth.When flower (gather, should to carry out time softer by not dry, the sharp thorn of bract of dew in morning as early as possible, but also too early unsuitable).Acrid in the mouth, warm in nature.GUIXIN, Liver Channel.There is promoting blood circulation to restore menstrual flow, effect of eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.Flos Carthami is containing Carthamus yellow and saffloside.
Pharmacological action:
Reduce blood pressure and regulating blood lipid action
Safflower extracts obviously reduces hyperlipidemia rats TC (triglyceride), TG (serum total cholesterol) and LDL-CHO (low-density lipoprotein cholesterol), points out it to have significant effect for reducing blood fat.Flos Carthami and the blood vessel of pharmacological component to cat and dog or rabbit thereof have obvious dilating effect in various degree, and along with the increase of Flos Carthami and pharmacological component dosage thereof, vasorelaxation action is more obvious, occurs more lasting blood pressure drops effect thereupon.Therefore, Flos Carthami has and reduces blood pressure and regulating blood lipid action, can be used for treating hypertriglyceridemia, hypercholesterolemia and high non-esterified fatty acidemia.Zhang Tuanxiao etc. carry out more deep research to the mechanism of action that Flos Carthami injection reduces Arteries of Rabbits blood pressure.The impact adopting common carotid artery intubation to carry out observer's rabbit arterial blood pressure in experiment to have produced after having injected Flos Carthami injection.Experimental result shows: after having injected the Flos Carthami injection of doses, and rabbit normal arterial pressure obviously reduces.Meanwhile, Nie Peihe etc. are also studied the impact that centrifugal cardiac function specifically produces S-A Hydroxysafflor yellow A and four kinds of K+ channel blockers.The S-A Hydroxysafflor yellow A that makes discovery from observation has the regulating action of negativity to cardiac muscle, reach the effect reduced blood pressure by the contractility of Inhibition test Mus cardiac muscle.
To the effect of consumption systems
Low dose of Flos Carthami is evident in efficacy to the Chronic stomach ache of the course of disease more than 6 months.The S-A Hydroxysafflor yellow A (HSYA) of debita spissitudo has certain inhibitory action to tumor, and the apoptosis of inducing tumor cell may be one of mechanism of its antitumor action.Flos Carthami polysaccharide has obvious inhibitory action to SGC-7901gastriccarcinomacellline in-vitro multiplication, and this inhibitory action has regular hour dependency and dose dependent; Flos Carthami polysaccharide can be lowered AktmRNA and express, and reduces the expression of Akt and p-Akt albumen, suppresses Akt path to play antitumor action.Flos Carthami polysaccharide can reduce SGC-7901gastriccarcinomacellline MMP, and by improving Bax gene expression, reducing Bcl-2 gene expression, and induce gastric cancer cell line SGC-7901 apoptosis, its effect has regular hour dependency.
Protect the liver effect of anti hepatic fibrosis
Through clinical trial, Flos Carthami injection, by suppressing the rising of alanine aminotransferase in liver perfusate, suppresses isolated perfusion, makes flow enhancement move closer to normal condition, thus reach the object improving liver function.Give the experimental mouse injection Flos Carthami injection of endotoxic hepatic injury, in experiment Hepar Mus perfusate, alanine aminotransferase is suppressed, and the NO level thereupon in serum declines, thus alleviates hepatic injury degree, plays liver protection effect.The effect of anti hepatic fibrosis of Flos Carthami may be partly express by strengthening interstitial collagenase gene, suppresses Expression of TIMP gene expression to complete simultaneously [9].Flos Carthami has obvious downward effect to hepatic stellate cell c-fos and c-jun gene expression.Flos Carthami injection can be active by reducing iNOS, then reduces Serum concentration of NO in hepatic injury, thus play the protective effect to acute liver damage.
The Chinese medicine composition of the application's Treatment chronic Hepatitis B is in preparation method, can according to the preparation method of Chinese medicine, also the preparation method of existing technology can be adopted, the dosage form of the medicament prepared by any one method above-mentioned all has the effect of Treatment chronic Hepatitis B, specific to which kind of preparation method of employing, need to consider production scale, and the needs of final medication crowd, and emphasis considers medication custom and the whether convenience of medication crowd.The type of medicament can comprise any one dosage form on pharmaceutics, such as pill, powder, tablet, unguentum, granule or capsule etc., also or the extract of this Chinese medicine composition water preparation, injection and the oral liquid etc. prepared.
This Chinese medicine composition or extract are prepared into pill, powder, tablet, unguentum, granule or capsule and water preparation, injection and oral liquid again after all can adding adjuvant.
In each technical scheme of the application, the adjuvant that adjuvant commonly uses by existing with medicament, can also use Sugarless type adjuvant as required or have sugar-type adjuvant.
Embodiment 1
A Chinese medicine composition for Treatment chronic Hepatitis B, its raw materials by weight portion proportioning is: capillary wormwood 8 parts, Radix Astragali 10 parts, 6 parts, Poria, Chao Bai Intraoperative 6 parts, Radix Salviae Miltiorrhizae 10 parts, Radix Angelicae Sinensis 6 parts, the Radix Paeoniae Alba 10 parts, Radix Paeoniae Rubra 6 parts, Fructus Ligustri Lucidi 8 parts, Endothelium Corneum Gigeriae Galli 6 parts, Fructus Lycii 6 parts and 6 parts, Flos Carthami.
In the present embodiment, to prepare capsule so that concrete preparation method to be described:
Radix Angelicae Sinensis, Radix Paeoniae Rubra and the Radix Paeoniae Alba are ground into fine powder, cross 80 mesh sieves, mix after spraying into 95% appropriate ethanol, seal 24 hours, then 60 DEG C dry to without alcohol taste, obtain fine powder for subsequent use.
Add water capillary wormwood and Rhizoma Atractylodis Macrocephalae (parched) distillating extracting oil, collects described volatile oil, described volatile oil water extraction, obtains refined volatile oil, extracts rear solution and medicinal residues; Extracting rear solution filters rear for subsequent use.
Decoction liquor is obtained after described medicinal residues, Poria, Radix Astragali, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, Fructus Lycii, Flos Carthami and Endothelium Corneum Gigeriae Galli being decocted with water; In the present embodiment, decoct with water three times, first time decocts and decocts for the second time and is 2 hours, and third time decocts 1 hour, and then the medicinal liquid merging decocted three times filters.
Being evaporated to relative density after merging described decoction liquor and described extraction rear solution is 1.20 ~ 1.30 (60 DEG C) thick paste; Described thick paste is mixed with described fine powder for subsequent use, through super-dry, sieve after obtain sieve upper part and lower part of screen divide; Described lower part of screen is divided after spraying into described refined volatile oil and mix, then mix with described oversize, seal 30 minutes, obtain compound preparation, then incapsulate.
Embodiment 2
A Chinese medicine composition for Treatment chronic Hepatitis B, its raw materials by weight portion proportioning is: capillary wormwood 23 parts, Radix Astragali 30 parts, 30 parts, Poria, Chao Bai Intraoperative 30 parts, Radix Salviae Miltiorrhizae 30 parts, Radix Angelicae Sinensis 30 parts, the Radix Paeoniae Alba 30 parts, Radix Paeoniae Rubra 30 parts, Fructus Ligustri Lucidi 23 parts, Endothelium Corneum Gigeriae Galli 22 parts, Fructus Lycii 22 parts and 22 parts, Flos Carthami.
In the present embodiment, to prepare capsule so that concrete preparation method to be described:
Radix Angelicae Sinensis, Radix Paeoniae Rubra and the Radix Paeoniae Alba are ground into fine powder, cross 80 mesh sieves, mix after spraying into 95% appropriate ethanol, seal 24 hours, then 60 DEG C dry to without alcohol taste, obtain fine powder for subsequent use.
Add water capillary wormwood and Rhizoma Atractylodis Macrocephalae (parched) distillating extracting oil, collects described volatile oil, described volatile oil water extraction, obtains refined volatile oil, extracts rear solution and medicinal residues; Extracting rear solution filters rear for subsequent use.
Decoction liquor is obtained after described medicinal residues, Poria, Radix Astragali, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, Fructus Lycii, Flos Carthami and Endothelium Corneum Gigeriae Galli being decocted with water; In the present embodiment, decoct with water three times, first time decocts and decocts for the second time and is 2 hours, and third time decocts 1 hour, and then the medicinal liquid merging decocted three times filters.
Being evaporated to relative density after merging described decoction liquor and described extraction rear solution is 1.20 ~ 1.30 (60 DEG C) thick paste; Described thick paste is mixed with described fine powder for subsequent use, through super-dry, sieve after obtain sieve upper part and lower part of screen divide; Described lower part of screen is divided after spraying into described refined volatile oil and mix, then mix with described oversize, seal 30 minutes, obtain compound preparation, then incapsulate.
Embodiment 3
A Chinese medicine composition for Treatment chronic Hepatitis B, its raw materials by weight portion proportioning is: capillary wormwood 15 parts, Radix Astragali 20 parts, 15 parts, Poria, Chao Bai Intraoperative 15 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Angelicae Sinensis 20 parts, the Radix Paeoniae Alba 15 parts, Radix Paeoniae Rubra 15 parts, Fructus Ligustri Lucidi 18 parts, Endothelium Corneum Gigeriae Galli 15 parts, Fructus Lycii 15 parts and 15 parts, Flos Carthami.
In the present embodiment, to prepare capsule so that concrete preparation method to be described:
Radix Angelicae Sinensis, Radix Paeoniae Rubra and the Radix Paeoniae Alba are ground into fine powder, cross 80 mesh sieves, mix after spraying into 95% appropriate ethanol, seal 24 hours, then 60 DEG C dry to without alcohol taste, obtain fine powder for subsequent use.
Add water capillary wormwood and Rhizoma Atractylodis Macrocephalae (parched) distillating extracting oil, collects described volatile oil, described volatile oil water extraction, obtains refined volatile oil, extracts rear solution and medicinal residues; Extracting rear solution filters rear for subsequent use.
Decoction liquor is obtained after described medicinal residues, Poria, Radix Astragali, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, Fructus Lycii, Flos Carthami and Endothelium Corneum Gigeriae Galli being decocted with water; In the present embodiment, decoct with water three times, first time decocts and decocts for the second time and is 2 hours, and third time decocts 1 hour, and then the medicinal liquid merging decocted three times filters.
Being evaporated to relative density after merging described decoction liquor and described extraction rear solution is 1.20 ~ 1.30 (60 DEG C) thick paste; Described thick paste is mixed with described fine powder for subsequent use, through super-dry, sieve after obtain sieve upper part and lower part of screen divide; Described lower part of screen is divided after spraying into described refined volatile oil and mix, then mix with described oversize, seal 30 minutes, obtain compound preparation, then incapsulate.
Embodiment 4
A Chinese medicine composition for Treatment chronic Hepatitis B, its raw materials by weight portion proportioning is: capillary wormwood 12 parts, Radix Astragali 20 parts, 15 parts, Poria, Chao Bai Intraoperative 15 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Angelicae Sinensis 15 parts, the Radix Paeoniae Alba 20 parts, Radix Paeoniae Rubra 20 parts, Fructus Ligustri Lucidi 12 parts, Endothelium Corneum Gigeriae Galli 10 parts, Fructus Lycii 10 parts and 10 parts, Flos Carthami.
In the present embodiment, to prepare capsule so that concrete preparation method to be described:
Radix Angelicae Sinensis, Radix Paeoniae Rubra and the Radix Paeoniae Alba are ground into fine powder, cross 80 mesh sieves, mix after spraying into 95% appropriate ethanol, seal 24 hours, then 60 DEG C dry to without alcohol taste, obtain fine powder for subsequent use.
Add water capillary wormwood and Rhizoma Atractylodis Macrocephalae (parched) distillating extracting oil, collects described volatile oil, described volatile oil water extraction, obtains refined volatile oil, extracts rear solution and medicinal residues; Extracting rear solution filters rear for subsequent use.
Decoction liquor is obtained after described medicinal residues, Poria, Radix Astragali, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, Fructus Lycii, Flos Carthami and Endothelium Corneum Gigeriae Galli being decocted with water; In the present embodiment, decoct with water three times, first time decocts and decocts for the second time and is 2 hours, and third time decocts 1 hour, and then the medicinal liquid merging decocted three times filters.
Being evaporated to relative density after merging described decoction liquor and described extraction rear solution is 1.20 ~ 1.30 (60 DEG C) thick paste; Described thick paste is mixed with described fine powder for subsequent use, through super-dry, sieve after obtain sieve upper part and lower part of screen divide; Described lower part of screen is divided after spraying into described refined volatile oil and mix, then mix with described oversize, seal 30 minutes, obtain compound preparation, then incapsulate.
Embodiment 5
A Chinese medicine composition for Treatment chronic Hepatitis B, its raw materials by weight portion proportioning is: capillary wormwood 20 parts, Radix Astragali 25 parts, 20 parts, Poria, Chao Bai Intraoperative 25 parts, Radix Salviae Miltiorrhizae 25 parts, Radix Angelicae Sinensis 20 parts, the Radix Paeoniae Alba 25 parts, Radix Paeoniae Rubra 25 parts, Fructus Ligustri Lucidi 15 parts, Endothelium Corneum Gigeriae Galli 15 parts, Fructus Lycii 20 parts and 15 parts, Flos Carthami.
In the present embodiment, by above-mentioned each component through three soak by water, it is 2-4 hour that first time decocts into second time decocting time, and decocting time is 1-2 hour for the third time, merge three decoction liquor and add adjuvant after concentrated, drying, be prepared into powder or powder as required.In the present embodiment, adjuvant use caramel or dextrin.
Embodiment 6
A Chinese medicine composition for Treatment chronic Hepatitis B, its raw materials by weight portion proportioning is: capillary wormwood 14 parts, Radix Astragali 18 parts, 20 parts, Poria, Chao Bai Intraoperative 22 parts, Radix Salviae Miltiorrhizae 23 parts, Radix Angelicae Sinensis 23 parts, the Radix Paeoniae Alba 20 parts, Radix Paeoniae Rubra 05 part, Fructus Ligustri Lucidi 14 parts, Endothelium Corneum Gigeriae Galli 10 parts, Fructus Lycii 10 parts and 12 parts, Flos Carthami.
In the present embodiment, Radix Angelicae Sinensis, Radix Paeoniae Rubra and the Radix Paeoniae Alba are ground into fine powder, cross 80 mesh sieves, obtain fine powder for subsequent use.
By remaining component through three soak by water, it is 2-4 hour that first time decocts into second time decocting time, decocting time is 1-2 hour for the third time, merge three decoction liquor and add adjuvant through concentrating, being mixed into fine powder for subsequent use and adjuvant, be prepared into granule, after drying, be prepared into granule, powder or powder as required.In the present embodiment, adjuvant use caramel or dextrin.
Embodiment 7
A Chinese medicine composition for Treatment chronic Hepatitis B, its raw materials by weight portion proportioning is: capillary wormwood 12 parts, Radix Astragali 20 parts, 15 parts, Poria, Chao Bai Intraoperative 15 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Angelicae Sinensis 15 parts, the Radix Paeoniae Alba 20 parts, Radix Paeoniae Rubra 20 parts, Fructus Ligustri Lucidi 12 parts, Endothelium Corneum Gigeriae Galli 10 parts, Fructus Lycii 10 parts and 10 parts, Flos Carthami.
For preparation, the present embodiment mentions that agent is described, above-mentioned each component is mentioned by solvent and obtains extracting solution, again each extracting solution is extracted liquid through steps such as extractions, again each extract is mixed, obtain water preparation or injection, or mixed extract is added adjuvant, such as the preparation such as glucose solution or sodium chloride solution corresponding water preparation, injection or oral liquid.In the present embodiment, be prior art by the mode of solution extraction, therefore, applicant is not described in detail.
For this Chinese medicine composition, the ratio change of each component permits, and all can play therapeutic effect, all belong to protection scope of the present invention.

Claims (10)

1. a Chinese medicine composition for Treatment chronic Hepatitis B, is characterized in that: its raw material is made up of capillary wormwood, the Radix Astragali, Poria, white Intraoperative, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Paeoniae Rubra, Fructus Ligustri Lucidi, Endothelium Corneum Gigeriae Galli, Fructus Lycii and Flos Carthami.
2. the Chinese medicine composition of Treatment chronic Hepatitis B according to claim 1, is characterized in that: the described Rhizoma Atractylodis Macrocephalae is Rhizoma Atractylodis Macrocephalae (parched); The described Radix Astragali is Radix Astragali; Described when being classified as Radix Angelicae Sinensis.
3. the Chinese medicine composition of Treatment chronic Hepatitis B according to claim 1 and 2, is characterized in that: its raw materials by weight portion proportioning is: capillary wormwood 8-23 part, Radix Astragali 10-30 part, Poria 6-30 part, Bai Intraoperative 6-30 part, Radix Salviae Miltiorrhizae 10-30 part, Radix Angelicae Sinensis 6-30 part, Radix Paeoniae Alba 10-30 part, Radix Paeoniae Rubra 6-30 part, Fructus Ligustri Lucidi 8-23 part, Endothelium Corneum Gigeriae Galli 6-22 part, Fructus Lycii 6-22 part and Flos Carthami 6-22 part.
4. the Chinese medicine composition of Treatment chronic Hepatitis B according to claim 3, is characterized in that: its raw materials by weight portion proportioning is preferably: capillary wormwood 10-16 part, Radix Astragali 15-25 part, Poria 10-23 part, Bai Intraoperative 10-23 part, Radix Salviae Miltiorrhizae 15-25 part, Radix Angelicae Sinensis 10-23 part, Radix Paeoniae Alba 15-25 part, Radix Paeoniae Rubra 10-23 part, Fructus Ligustri Lucidi 10-16 part, Endothelium Corneum Gigeriae Galli 8-15 part, Fructus Lycii 8-15 part and Flos Carthami 8-15 part.
5. the Chinese medicine composition of Treatment chronic Hepatitis B according to claim 4, is characterized in that: its raw materials by weight portion proportioning is more preferably: capillary wormwood 12 parts, the Radix Astragali 20 parts, Poria 15 parts of, Bai Intraoperative 15 parts, Radix Salviae Miltiorrhizae 20 parts, Radix Angelicae Sinensis 15 parts, the Radix Paeoniae Alba 20 parts, Radix Paeoniae Rubra 20 parts, Fructus Ligustri Lucidi 12 parts, Endothelium Corneum Gigeriae Galli 10 parts, Fructus Lycii 10 parts and 10 parts, Flos Carthami.
6. a Chinese medicine preparation for Treatment chronic Hepatitis B, adopts Chinese medicine constituent any one of claim 1 to 5, it is characterized in that: it makes the medicament of the dosage form on any one pharmaceutics; Or it makes the medicament of the dosage form on any one pharmaceutics after adding adjuvant.
7. a Chinese medicine preparation for Treatment chronic Hepatitis B, adopts Chinese medicine constituent any one of claim 1 to 5, it is characterized in that: the medicament of the dosage form on any one pharmaceutics made by its extractant; Or it extracts the medicament that the dosage form on any one pharmaceutics made by preparation after adding adjuvant.
8. the Chinese medicine preparation of the Treatment chronic Hepatitis B according to claim 6 or 7, is characterized in that: described medicament is pill, powder, tablet, unguentum, water preparation, injection, oral liquid, granule or capsule.
9. treat a preparation method for the Chinese medicine preparation of chronic hepatitis, it is characterized in that: comprise the following steps:
Radix Angelicae Sinensis, Radix Paeoniae Rubra and the Radix Paeoniae Alba are ground into fine powder, mix after spraying into ethanol, sealing, then oven dry obtains fine powder for subsequent use;
Add water capillary wormwood and the Rhizoma Atractylodis Macrocephalae distillating extracting oil, collects described volatile oil, described volatile oil water extraction, obtains refined volatile oil, extracts rear solution and medicinal residues;
Decoction liquor is obtained after described medicinal residues, Poria, the Radix Astragali, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, Fructus Lycii, Flos Carthami and Endothelium Corneum Gigeriae Galli being decocted with water;
Thick paste is concentrated into after merging described decoction liquor and described extraction rear solution; Described thick paste is mixed with described fine powder for subsequent use, through super-dry, sieve after obtain sieve upper part and lower part of screen divide; Described lower part of screen is divided after spraying into described refined volatile oil and mix, then mix with described oversize, obtain compound preparation.
10. the preparation method of the Chinese medicine preparation for the treatment of chronic hepatitis according to claim 9, is characterized in that: described soak by water decocts for three times totally, and wherein decocting time is identical with second time decocting time for the first time, but is greater than third time decocting time; Decoct the decoction liquor mixing obtained for three times.
CN201510937182.XA 2015-12-15 2015-12-15 Traditional Chinese medicinal composition and preparation for treating chronic hepatitis B and preparation method of preparation Pending CN105456517A (en)

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WO2022237007A1 (en) * 2021-05-11 2022-11-17 重庆医科大学 Use of cow parsnip as active ingredient in preparing drug for treating hepatitis b

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1644213A (en) * 2004-11-12 2005-07-27 潘求谛 Chinese medicinal preparation for treating liver cancer, hepatitis B cirrhosis and preventing liver fibrillation and preparation thereof
CN101357219A (en) * 2008-09-04 2009-02-04 兰州佛慈制药股份有限公司 Medicine for treating chronic hepatitis b
CN101406656A (en) * 2008-10-23 2009-04-15 李艳 Medicament for treating hepatic cirrhosis with hypoproteinemia after hepatitis
CN103243347A (en) * 2012-02-13 2013-08-14 旭化成化学株式会社 Cation exchange film and electrolytic tank with the same
CN103243345A (en) * 2012-02-13 2013-08-14 旭化成化学株式会社 Cation exchange film and electrolytic tank with the same
CN103316305A (en) * 2013-07-13 2013-09-25 华菊 Traditional Chinese medicine composition for treating liver cirrhosis and preparation method thereof
CN103668319A (en) * 2012-09-14 2014-03-26 旭化成化学株式会社 Ion exchange membrane, manufacturing method of ion exchange membrane, and electrolytic cell
CN103908640A (en) * 2014-04-25 2014-07-09 解建峰 Traditional Chinese medicinal composition for treating liver cirrhosis
CN104984248A (en) * 2015-07-13 2015-10-21 王吉坤 Traditional Chinese medicinal compound for treating hepatitis
CN105381334A (en) * 2015-12-15 2016-03-09 骅狮生命科技股份有限公司 Traditional Chinese medicine composition for treating fatty liver and its preparation and preparation method

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1644213A (en) * 2004-11-12 2005-07-27 潘求谛 Chinese medicinal preparation for treating liver cancer, hepatitis B cirrhosis and preventing liver fibrillation and preparation thereof
CN101357219A (en) * 2008-09-04 2009-02-04 兰州佛慈制药股份有限公司 Medicine for treating chronic hepatitis b
CN101406656A (en) * 2008-10-23 2009-04-15 李艳 Medicament for treating hepatic cirrhosis with hypoproteinemia after hepatitis
CN103243347A (en) * 2012-02-13 2013-08-14 旭化成化学株式会社 Cation exchange film and electrolytic tank with the same
CN103243345A (en) * 2012-02-13 2013-08-14 旭化成化学株式会社 Cation exchange film and electrolytic tank with the same
CN103668319A (en) * 2012-09-14 2014-03-26 旭化成化学株式会社 Ion exchange membrane, manufacturing method of ion exchange membrane, and electrolytic cell
CN103316305A (en) * 2013-07-13 2013-09-25 华菊 Traditional Chinese medicine composition for treating liver cirrhosis and preparation method thereof
CN103908640A (en) * 2014-04-25 2014-07-09 解建峰 Traditional Chinese medicinal composition for treating liver cirrhosis
CN104984248A (en) * 2015-07-13 2015-10-21 王吉坤 Traditional Chinese medicinal compound for treating hepatitis
CN105381334A (en) * 2015-12-15 2016-03-09 骅狮生命科技股份有限公司 Traditional Chinese medicine composition for treating fatty liver and its preparation and preparation method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
沈阳药学院药剂教研组: "《常用药物制剂（修订版）》", 30 April 1979 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022237007A1 (en) * 2021-05-11 2022-11-17 重庆医科大学 Use of cow parsnip as active ingredient in preparing drug for treating hepatitis b

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