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CN105396170A - Medical surgical suture and preparation method thereof - Google Patents

Medical surgical suture and preparation method thereof Download PDF

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Publication number
CN105396170A
CN105396170A CN201510802365.0A CN201510802365A CN105396170A CN 105396170 A CN105396170 A CN 105396170A CN 201510802365 A CN201510802365 A CN 201510802365A CN 105396170 A CN105396170 A CN 105396170A
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herba
chitosan
suture thread
medical operation
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不公告发明人
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/10—At least partially resorbable materials containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a medical surgical suture. The surgical suture is mainly prepared from, by weight, 48-62 parts of chitosan, 30-40 parts of silk protein, 4-7 parts of tangerine leaves, 3-6 parts of woundwort, 5-8 parts of short hairy antenoron, 7-11 parts of Chineses trichosanthes roots, 5-9 parts of lindera angustifolia cheng, 3-7 parts of hairyvein agrimony, 6-10 parts of ficus tikoua, 8-12 parts of japan clover herbs, 4-8 parts of rhizoma bletillae and 5-9 parts of Chinese umbrellaleaf rhizomes and roots. The medical surgical suture further has the advantages that healing of a wound can be promoted, ulcer resistance is achieved, the defect that chitosan medical fibers are quick in tensile rigidity loss in the in-vivo environment and other defects can be remedied, a tissue reaction is avoided, safety and effectiveness are achieved, and no toxic or side effect exists.

Description

A kind of medical operation suture thread and preparation method thereof
Technical field
The present invention relates to field of medical materials, particularly relate to a kind of medical operation suture thread and preparation method thereof.
Background technology
Medical operation suture thread refers in the middle of surgical operation, for the special line of one of wound ligation, Suture hemostasis and tissue apposition.Two classes can be divided into: nonabsorable line and absorbable thread according to its biodegradability.Desirable stitching thread should have to be stablized in vivo, and tissue reaction is little, not easily unclamps after knotting, unlikely wearing and tearing of suture itself or split.Absorbable suture is nontoxic, with tissue and blood compatibility good, degradable.The raw body absorbability suture material of initial use is gutstring, and it is the pure collagen fiber obtained after Intestinum caprae seu ovis mucosa or the despumation of Intestinum Bovis seu Bubali mucosa.This fiber smoothness is excellent, tuberosity position good stability, but shortcoming is that composition is uneven, biological respinse is strong, decomposition rate is too fast, absorption is unstable.
Desirable operation suture thread should before healing and tissue compatible, and the stitching thread of healing must not be removed, and can slowly be absorbed by the body, and does not destroy normal healing in agglutination.Chitin is well positioned to meet above 3 points.The wide material sources of chitin, according to estimates, occurring in nature chitin amount is about 10,000,000,000 tons, is only second to cellulose, is second largest living resources on the earth.Can produce in a large number, good biocompatibility, can biodegradation under the effect of human chitinase, catabolite safety non-toxic, and as a kind of natural alkaline polysaccharide, also having suitable biological activity, be an extremely potential absorbable and degradable operation suture thread, but product sterilizing ability is made by chitosan and mechanical performance all has much room for improvement.
Application publication number CN104958780A(application number 201510372110.5) Chinese invention patent document disclose a kind of medical operation suture thread and preparation method thereof, comprise the following raw material counted by weight: chitosan 1.2-2.8 part, Herba Cymbopogonis Citrari quintessence oil 0.3-1.5 part, glycerol 1.2-1.8 part, hyaluronic acid 0.05-0.08 part, vitamin E 0.1-0.8 part, Cuttlefish soup 0.1-0.8 part.Application publication number CN104940987A(application number 201510308530.7) Chinese invention patent document disclose a kind of high-intensity absorbable stitching thread and preparation method thereof, be made up of each component of following mass parts: chitosan 39-51 part, zinc acetate 7-16 part, glutaraldehyde 2-11 part, poly butyric ester 11-26 part, calcium hydroxy phosphate 2-8 part, sulfonated castor oil 13-24 part, PGA 9-17 part, itaconic anhydride 1-8 part.Application publication number CN104368039A(application number 201410684311.4) Chinese invention patent document disclose a kind of Surgical Absorbable Suture and preparation method thereof, comprise the component of following weight portion: polydioxanone 40-50 part, polylactic acid 20-25 part, Rhopilema esculenta collagen 10-15 part, chitosan 1-5 part, cross-linking agent 3-5 part, stabilizing agent 1-3 part and antibacterial 2-4 part.
The stitching thread that current medical circle is conventional, not only cost of manufacture is high, and processing technology is numerous and diverse, and it is undesirable that some patients sew up rear wound healing, also needs carry out second operation and take out stitches, and adds a lot of burden, remain to be further improved and improve to hospital and patient.
Summary of the invention
In order to make up above-mentioned deficiency, the object of the present invention is to provide a kind of medical operation suture thread and preparation method thereof, at bacteriostasis and sterilization, the aspect such as wound healing, degradability has significant advantage, and preparation cost is low, mature preparation process etc.
Technical scheme of the present invention is:
A kind of medical operation suture thread, is prepared from by following main materials medicine, is weight portion: chitosan 48-62, fibroin 30-40, Folium Citri tangerinae 4-7, Herba Stachydis Japonicae 3-6, Herba Colei Pumili 5-8, Radix Trichosanthis 7-11, Lindera angustifolia Cheng 5-9, Herba Agrimoniae 3-7, Caulis et Folium fici Tikouae 6-10, Herba Kummerowiae Striatae 8-12, Pseudobulbus Bletillae (Rhizoma Bletillae) 4-8, Rhizoma et Radix Diphylleiae 5-9.
In preferred scheme, chitosan 52-58, fibroin 32-38, Folium Citri tangerinae 5-6, Herba Stachydis Japonicae 4-5, Herba Colei Pumili 6-7, Radix Trichosanthis 8-10, Lindera angustifolia Cheng 6-8, Herba Agrimoniae 4-6, Caulis et Folium fici Tikouae 7-9, Herba Kummerowiae Striatae 9-11, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-7, Rhizoma et Radix Diphylleiae 6-8.
Be more preferably, chitosan 55, fibroin 35, Folium Citri tangerinae 5.5, Herba Stachydis Japonicae 4.5, Herba Colei Pumili 6.5, Radix Trichosanthis 9, Lindera angustifolia Cheng 7, Herba Agrimoniae 5, Caulis et Folium fici Tikouae 8, Herba Kummerowiae Striatae 10, Pseudobulbus Bletillae (Rhizoma Bletillae) 6, Rhizoma et Radix Diphylleiae 7.
A preparation method for medical operation suture thread, step is as follows:
(1) Pseudobulbus Bletillae (Rhizoma Bletillae) be placed in the concentration of 1.2-1.6 times amount be 0.5% Alumen water soak 1.6-2.8 hour (concentration that preferred Pseudobulbus Bletillae (Rhizoma Bletillae) is placed in 1.3-1.5 times amount be 0.5% Alumen water soak 2.0-2.4 hour), take out, load in water rice steamer, supreme gas is steamed in big fire, take out while hot, drying, grinds to form fine powder; The yellow wine (preferably adding the yellow wine of 0.22-0.28 times amount in Radix Trichosanthis) of 0.18-0.32 times amount is added in Radix Trichosanthis, mix thoroughly, after yellow wine is all absorbed, be placed on tile, slow fire roasting is to surface in yellow slightly focal spot, and taking-up cools, be milled to fine powder, mix with the Rhizoma Bletillae powder after process, sieve for subsequent use;
(2) by Folium Citri tangerinae, Lindera angustifolia Cheng and Caulis et Folium fici Tikouae mixing, the mature vinegar adding 2.2-3.4 times amount soaks 13-25 minute (mature vinegar preferably adding 2.4-3.2 times amount soaks 15-23 minute), take out, with Herba Stachydis Japonicae, Herba Colei Pumili, Herba Agrimoniae, Herba Kummerowiae Striatae and Rhizoma et Radix Diphylleiae are together placed in marmite, add the redistilled water (preferably adding the redistilled water of 7.5-10.5 times of raw material dose) of 6.5-11.5 times of raw material dose, slow fire boiling twice, first time decocts 18-36 minute (preferably first time decocts 20-34 minute), second time decocts 10-20 minute (preferably second time decocts 13-17 minute), merge twice decocting liquid, filter, step (1) gained mixing fine powders is added in filtrate, slow fire boiling 6-16 minute (preferred slow fire boiling 8-14 minute), filter, filtrate reduced in volume is to 1/4 of original volume, obtain the concentrated liquid of tradition Chinese medicine, for subsequent use,
(3) chitosan is dissolved in the aqueous acetic acid of 2%, be mixed with the chitosan solution (being preferably mixed with the chitosan solution that concentration is 0.8-1.2%) that concentration is 0.5%-1.5%, gained chitosan solution mixes with step (2) gained the concentrated liquid of tradition Chinese medicine, add fibroin, diffusant and antibacterial, abundant stirring, after filtration, obtained spinning solution after deaeration, for subsequent use;
(4) step (3) gained spinning solution is entered after spinning pump metering, metre filter the spinning head with eyelet, the spinning solution extruded from spinneret orifice solidifies for the first time through sodium hydroxide/ethyl alcohol solution, carry out secondary through the distilled water of 10-26 DEG C again to solidify (preferably carrying out secondary through the distilled water of 14-22 DEG C again to solidify), make monofilament, for subsequent use;
(5) by after step (4) gained monofilament washing and drying, by the inside and outside stitching thread being twisted into various model, sterilizing, encapsulation, to obtain final product.
The preparation method of above-mentioned a kind of medical operation suture thread, preferred scheme is, the middle 50-80 mesh sieve excessively of step (1) (preferred 60-70 mesh sieve excessively, mistake 65 mesh sieve be more preferably).
The preparation method of above-mentioned a kind of medical operation suture thread, preferred scheme is, the glycerol of to be mass fraction the be 0.7-1.1% of diffusant described in step (3) (glycerol of preferred described diffusant to be mass fraction be 0.8-1.0%, the described diffusant be more preferably to be mass fraction be 0.9% glycerol).
The preparation method of above-mentioned a kind of medical operation suture thread, preferred scheme is, in step (3) antibacterial to be mass fraction be 0.9-1.6% Oleum Ricini (Oleum Ricini of preferred antibacterial to be mass fraction be 1.1-1.4%, the antibacterial be more preferably to be mass fraction be 1.3% Oleum Ricini).
The preparation method of above-mentioned a kind of medical operation suture thread, preferred scheme is, in step (4), the temperature of sodium hydroxide/ethyl alcohol solution is 32-52 DEG C (temperature of preferred sodium hydroxide/ethyl alcohol solution is 37-47 DEG C, and the temperature of the sodium hydroxide/ethyl alcohol solution be more preferably is 42 DEG C).
The preparation method of above-mentioned a kind of medical operation suture thread, preferred scheme is, the aperture of step (4) perforations is the aperture of the preferred eyelet of 0.05-0.12mm(is 0.07-0.10mm, and the aperture of the eyelet be more preferably is 0.09mm).
The preparation method of above-mentioned a kind of medical operation suture thread, preferred scheme is, in step (5), sterilization method is N 2the lower ethylene oxide sterilizing of protection.
Effect or the physicochemical property of each raw material components are respectively:
Chitosan: chitosan is the product that chitin takes off N-acetyl group; generally speaking, N-acetyl group slough more than 55% just can be referred to as chitosan, in other words; can dissolve the chitosan of 1% in 1% acetic acid or 1% hydrochloric acid, this chitosan is referred to as chitosan.Physiologically active: 1, control cholesterol; 2, Antibacterial activity: chitosan is easy to dissolve in weak acid solvent, it is worthy of note that these amino are by carrying out anti-bacteria in conjunction with negatron containing amino in the solution after dissolving especially.The Antibacterial activity of chitosan, makes it have a wide range of applications in fields such as medicine, weaving and food.3, prevention and corntrol hypertension; 4, absorption and excretion heavy metal; 5, immune effect: chitosan has higher protein adsorption ability; Under the effect of digestive enzyme (lysozyme), chitosan tool degradability; Chitosan is easy to be processed into line, is applicable to the medical material making wire or lamellar; Chitosan has affinity and dissolubility, is applicable to produce each analog derivative; Chitosan has higher chemism; The retentiveness of chitosan is high; In serum, the easy degraded and absorbed of chitosan; Chitosan has higher biological degradability; Chitosan shows the effect selectively highly suppressing Streptococcus oralis growth, does not affect the growth of other beneficial bacterias simultaneously.
Fibroin: have another name called: fibroin albumen.Fibroin albumen, it is the natural polymer fibrin extracted from silkworm silk, content accounts for the 70%-80% of silkworm silk, and containing 18 seed amino acids, wherein glycine (gly), alanine (ala) and serine (ser) account for more than 80% of total composition.Fibroin itself has good mechanical performance and physicochemical property, as good pliability and tensile strength, breathable moisture permeability, slow-releasing etc., and can obtain different forms through different disposal, as fiber, solution, powder, film and gel etc.Due to the physicochemical property of its uniqueness, current fibroin material is studied widely in field of biomedical materials, as immobilized enzyme material, cell culture substrate, medicinal slow release agent, artificial organ etc.Due to silk protein and human body skin keratin matter fairly similar, both have fabulous affinity; Due to the chemical constitution that silk protein molecule is special, so silk protein has good hygroscopicity and wet dissipation performance, the change of surrounding can be adapted to, play natural damping, improve human body skin nutrition, prevent skin wrinkling, strengthen Skin Cell vigor and elasticity, promotion cell metabolism and maintain skin normal physiological condition; Silk protein also has absorption ultraviolet, prevents the effect that solar radiation damages human body skin.
Folium Citri tangerinae: base is former: be the leaf of the multiple Fructus Citri tangerinae classes such as rutaceae tangerine produced in fujian province or Zhu's Fructus Citri tangerinae.Character: dried leaves multireel contracts, in Pedicellus et Pericarpium Trapae shape oblong or ellipse after open and flat, surperficial celadon or yellow green, smooth, can according to seeing numerous transparent glandule points to light.Nature and flavor: toil are flat.Gui Jing: Zhu Zhenheng: " enter liver channel of foot-Jueyin edema caused by disorder of QI." function cures mainly: soothing the liver, circulation of qi promoting, reduces phlegm, detumescence poison.Control hypochondriac pain, acute mastitis, lung abscess, cough, chest and diaphragm feeling of fullness, hernia.
Herba Stachydis Japonicae: base is former: be herb or the root of labiate Herba Stachydis Japonicae, magnificent Herba Stachydis Japonicae or Herba Stachydis.Nature and flavor: acrid in the mouth; Cool in nature.Gui Jing: return lung; Stomach warp.Function cures mainly: heat-clearing and toxic substances removing; Cough-relieving sore-throat relieving; Hemostasia and detumescence.Main flu; Acute filthy disease; Consumptive lung disease; Lung abscess; Wind syndrome of head is dizzy; Pharyngalgia; Between mistake; Spit blood; Spitting of blood; Epistaxis; Metrorrhagia; Dysentery; Stranguria; Treating swelling and pain by traumatic injury.
Herba Colei Pumili: base is former: be the herb of aristolochiaceae plant Herba Colei Pumili and Asarum longerhizomatosum.Chemical analysis: Herba Colei Pumili herb (dry product) is containing volatile oil 0.5%, and in volatile oil there be composition: Borneolum Syntheticum, borneol acetate, 3,5-dimethoxy-p, safrole, transcaryophyllene, β-gurjunene, trans-β-farnesene, methyleugenol, the orange tertiary alcohol, asaricin, elemicine, Camphora, beta pinene.Nature and flavor: pungent; Bitter; Temperature; Mild toxicity.Gui Jing: lung; Liver; Spleen; Stomach warp.Function cures mainly: dispelling cold by warming the meridian; Expelling phlegm for arresting cough; Dissipating blood stasis for subsidence of swelling; Promoting the circulation of QI to relieve pain.Main cough due to wind and cold; Anemofrigid cold; Chronic bronchitis; Asthma; Chronic gastritis; Wind and cold arthralgia pain; Caries pain; Traumatic injury; Venom.
Radix Trichosanthis: base is former: be the root of cucurbitaceous plant Fructus Trichosanthis.Nature and flavor: sweetness and bitterness acid are cool.Gui Jing: enter lung, stomach warp.Function cures mainly: promote the production of body fluid, and quenches the thirst, and pathogenic fire reducing is moisturized, evacuation of pus, detumescence.Control calentura thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid complicated by anal fistula.
Lindera angustifolia Cheng: base is former: the root of Lauraceae Lindera plant Ramulus et Folium Linderae Angustifoliae or branch and leaf.Nature and flavor: pungent, micro-puckery, temperature.Function cures mainly: expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, removing toxic substances and promoting subsidence of swelling.For flu, headache, dyspepsia, gastroenteritis, dysentery, rheumatic arthritis, numb, traumatic injury, carbuncle sore tumefacting virus, urticaria, lymphoid tuberculosis.
Herba Agrimoniae: base is former: be the herb of rosaceous plant Agrimony.Chemical analysis: herb is containing agrimonine, agrimonolide, tannin (for Jiao's property catechol tannin, gallotannin etc.), sterol, organic acid, phenolic constituent, Saponin etc.Root is containing tannin 8.9%, and stem is containing tannin 6.5%, and leaf is containing tannin 16.4%.Stem, leaf are also containing luteolin-7-β-glycoside and apigenin-7-β-glycoside.Nature and flavor: toil are flat.Gui Jing: enter lung, liver, spleen channel.Function cures mainly: hemostasis, stomach invigorating.Control spitting of blood, spit blood, hematuria, has blood in stool, dysentery, bleeding not during menses, and impairment caused by overstrain takes off power, carbuncle, traumatic injury, wound hemorrhage.
Caulis et Folium fici Tikouae: base is former: be stem, the leaf of moraceae plants Radix Pachyrhizi Erosi.Nature and flavor: bitter, cold.Function cures mainly: heat clearing away, and dampness removing is invigorated blood circulation, removing toxic substances.Control cough due to pathogenic wind-heat, dysentery, edema, jaundice, rheumatalgia, bleeding hemorrhoids, amenorrhea, leukorrhagia, infantile dyspepsia, traumatic injury, innominate toxic swelling.
Herba Kummerowiae Striatae: base is former: be the herb of leguminous plant Herba Kummerowiae Striatae and perpendicular hair chicken.Pharmacological action: Herba Kummerowiae Striatae water logging agent in vitro to four kinds of dysentery bacteriums (Fu Shi, Song Shi, will Hayes, Shu Shi) and large intestine stalk bacterium without antibacterial action, only alcohol immersion shows faint effect to bacterium flexneri.K.stipvlacea infusion all has certain antibacterial action to Fu Shi, Shu Shi, dysentery bacterium in vitro.Nature and flavor: sweet; Pungent; Micro-hardship; Property is put down.Gui Jing: liver; Spleen; Lung; Kidney channel.Function cures mainly: heat-clearing and toxic substances removing; Invigorating spleen to remove dampness; Promoting blood circulation and hemostasis.Main cold, fever; Heat-damp in summer is vomited and diarrhoea; Jaundice; Carbuncle furuncle; Dysentery; Infantile malnutrition; Stranguria with blood; Spitting of blood; Epistaxis; Traumatic injury; Leucorrhea with red and white discharge.
Pseudobulbus Bletillae (Rhizoma Bletillae): base is former: be the tuber of orchid Pseudobulbus Bletillae (Rhizoma Bletillae).Chemical analysis: fresh tuber moisture content 14.6%, starch 30.48%, glucose 1.5%.Again containing volatile oil, phlegmatic temperament.Root contains bletilla mannan, the glucomannan be made up of 4 parts of mannose and 1 part of glucose.Nature and flavor: bitter sweet, cool.Gui Jing: enter lung meridian.Function cures mainly: tonifying the lung, hemostasis, detumescence, granulation promoting, sore.Control lung and hinder hemoptysis, epistaxis, incised wound is hemorrhage, swollen ulcer drug, canker sores, and soup fire is burnt, rhagadia manus et pedis.
Rhizoma et Radix Diphylleiae: base is former: be the rhizome of Berberidaceae plant China unmrellaleaf.Chemical analysis: root contains podophyllin, between dehydropodophyllotoxin and nimbecetin, the root of platymiscium unmrellaleaf contains nimbecetin, Quercetin, podophyllin, β-apopicropodophyllin, diphyllin, picropodophyllin, podophyllin, dehydropodophyllotoxin, apopicropodophyllin, diphyllin, picropodophyllin Dou Shi lignan class material.Nature and flavor: bitter; Pungent; Property is put down.Gui Jing: liver; Kidney channel.Function cures mainly: heat-clearing and toxic substances removing; Blood circulation promoting and blood stasis dispelling; Expelling wind and removing dampness.Main air pain of dampness syndrome; Traumatic injury; Menoxenia; Lower abdomen pain; Venom; Carbuncle furuncle.
A kind of medical operation suture thread scientific formula provided by the invention, preparation method is simple, products obtained therefrom function admirable, easy to use.In addition, excellent results of the present invention also shows:
1,chitosan combines with other Chinese medicine raw material by the present invention, and gained stitching thread intensity is high, pliability good, stable chemical performance, can meet the needs of infected wound and excessive fat myometrial suture, implants for a long time and without rejection;
2,gained stitching thread of the present invention can not only impel wound healing, antiulcer etc., can also make up the chitosan medical fiber defects such as the loss of anti-tensile hardness is fast in environment in vivo, avoid tissue reaction to occur, safe and effective, without any side effects;
3,stitching thread of the present invention can absorb degraded in vivo completely, without the need to taking out, has good biocompatibility simultaneously: non-stimulated to human body, without sensitivity response.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1a kind of medical operation suture thread, is prepared from by following main materials medicine, is weight portion (45g/ part): chitosan 48 parts, fibroin 30 parts, Folium Citri tangerinae 4 parts, Herba Stachydis Japonicae 3 parts, Herba Colei Pumili 5 parts, Radix Trichosanthis 7 parts, Lindera angustifolia Cheng 5 parts, Herba Agrimoniae 3 parts, Caulis et Folium fici Tikouae 6 parts, Herba Kummerowiae Striatae 8 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 4 parts, Rhizoma et Radix Diphylleiae 5 parts.
A kind of preparation method of medical operation suture thread is:
(1) Pseudobulbus Bletillae (Rhizoma Bletillae) be placed in the concentration of 1.2 times amount be 0.5% Alumen water soak 1.6 hours, take out, load in water rice steamer, supreme gas is steamed in big fire, takes out while hot, dry, grinds to form fine powder; In Radix Trichosanthis, add the yellow wine of 0.18 times amount, mix thoroughly, after yellow wine is all absorbed, be placed on tile, slow fire roasting is to surface in yellow slightly focal spot, and taking-up cools, and is milled to fine powder, mixes with the Rhizoma Bletillae powder after process, crosses 50 mesh sieves, for subsequent use;
(2) Folium Citri tangerinae, Lindera angustifolia Cheng and Caulis et Folium fici Tikouae are mixed, the mature vinegar adding 2.2 times amount soaks 13 minutes, take out, together be placed in marmite with Herba Stachydis Japonicae, Herba Colei Pumili, Herba Agrimoniae, Herba Kummerowiae Striatae and Rhizoma et Radix Diphylleiae, add the redistilled water of 6.5 times of raw material doses, slow fire boiling twice, first time decocts 18 minutes, and second time decocts 10 minutes, merge twice decocting liquid, filter, in filtrate, add step (1) gained mixing fine powders, slow fire boiling 6 minutes, filter, filtrate reduced in volume, to 1/4 of original volume, obtains the concentrated liquid of tradition Chinese medicine, for subsequent use;
(3) chitosan is dissolved in the aqueous acetic acid of 2%, be mixed with the chitosan solution that concentration is 0.5%, gained chitosan solution mixes with step (2) gained the concentrated liquid of tradition Chinese medicine, add fibroin, the diffusant glycerol of 0.7% (diffusant to be mass fraction be) and the antibacterial Oleum Ricini of 0.9% (antibacterial to be mass fraction be), abundant stirring, after filtration, obtained spinning solution after deaeration, for subsequent use;
(4) by step (3) gained spinning solution through spinning pump metering, the aperture entered with eyelet is the spinning head of 0.05mm after metre filter, the spinning solution extruded from spinneret orifice solidifies for the first time through the sodium hydroxide/ethyl alcohol solution that temperature is 32 DEG C, carry out secondary through the distilled water of 10 DEG C again to solidify, make monofilament, for subsequent use;
(5) by after step (4) gained monofilament washing and drying, by the inside and outside stitching thread being twisted into various model, N 2the lower ethylene oxide sterilizing of protection, encapsulation, to obtain final product.
The using method of gained medical operation suture thread of the present invention is: for operation stitching, ligation etc. such as human body skin, subcutaneous tissue, fascia, blood vessel, nerve, muscle tendons, after wound healing, without the need to taking out.
typical case one: old XX, female, 32 years old, people from Heze.Patient finds there is the parcel heaved near right axillary fossa from unexpected the year before, and about Fructus Jujubae is so large, touch without pain, Non Apparent Abnormality, does not attach the importance.After three months, patient obviously feels that parcel becomes large, has pain symptom in Menstrual Period affected part.Patient, after household's mediation, comes my institute on the 6th in JIUYUE in 2013 and checks.Be diagnosed as subtropics vortex on inspection.Agree to row subtropics vortex excision through patient and family members thereof, in surgical suturing process, use a kind of medical operation suture thread of the present embodiment gained to sew up.Observe patient's suture after sewing up one week, wound recovers good, without anaphylaxis; After one month, patient wound heals completely, and stitching thread absorbs completely, without obvious stitch vestige.
embodiment 2a kind of medical operation suture thread, is prepared from by following main materials medicine, is weight portion (25g/ part): chitosan 62 parts, fibroin 40 parts, Folium Citri tangerinae 7 parts, Herba Stachydis Japonicae 6 parts, Herba Colei Pumili 8 parts, Radix Trichosanthis 11 parts, Lindera angustifolia Cheng 9 parts, Herba Agrimoniae 7 parts, Caulis et Folium fici Tikouae 10 parts, Herba Kummerowiae Striatae 12 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 8 parts, Rhizoma et Radix Diphylleiae 9 parts.
A kind of preparation method of medical operation suture thread is:
(1) Pseudobulbus Bletillae (Rhizoma Bletillae) be placed in the concentration of 1.6 times amount be 0.5% Alumen water soak 2.8 hours, take out, load in water rice steamer, supreme gas is steamed in big fire, takes out while hot, dry, grinds to form fine powder; In Radix Trichosanthis, add the yellow wine of 0.32 times amount, mix thoroughly, after yellow wine is all absorbed, be placed on tile, slow fire roasting is to surface in yellow slightly focal spot, and taking-up cools, and is milled to fine powder, mixes with the Rhizoma Bletillae powder after process, crosses 80 mesh sieves, for subsequent use;
(2) Folium Citri tangerinae, Lindera angustifolia Cheng and Caulis et Folium fici Tikouae are mixed, the mature vinegar adding 3.4 times amount soaks 25 minutes, take out, together be placed in marmite with Herba Stachydis Japonicae, Herba Colei Pumili, Herba Agrimoniae, Herba Kummerowiae Striatae and Rhizoma et Radix Diphylleiae, add the redistilled water of 11.5 times of raw material doses, slow fire boiling twice, first time decocts 36 minutes, and second time decocts 20 minutes, merge twice decocting liquid, filter, in filtrate, add step (1) gained mixing fine powders, slow fire boiling 16 minutes, filter, filtrate reduced in volume, to 1/4 of original volume, obtains the concentrated liquid of tradition Chinese medicine, for subsequent use;
(3) chitosan is dissolved in the aqueous acetic acid of 2%, be mixed with the chitosan solution that concentration is 1.5%, gained chitosan solution mixes with step (2) gained the concentrated liquid of tradition Chinese medicine, add fibroin, the diffusant glycerol of 1.1% (diffusant to be mass fraction be) and the antibacterial Oleum Ricini of 1.6% (antibacterial to be mass fraction be), abundant stirring, after filtration, obtained spinning solution after deaeration, for subsequent use;
(4) by step (3) gained spinning solution through spinning pump metering, the aperture entered with eyelet is the spinning head of 0.12mm after metre filter, the spinning solution extruded from spinneret orifice solidifies for the first time through the sodium hydroxide/ethyl alcohol solution that temperature is 52 DEG C, carry out secondary through the distilled water of 26 DEG C again to solidify, make monofilament, for subsequent use;
(5) by after step (4) gained monofilament washing and drying, by the inside and outside stitching thread being twisted into various model, N 2the lower ethylene oxide sterilizing of protection, encapsulation, to obtain final product.
The using method of gained medical operation suture thread of the present invention is: for operation stitching, ligation etc. such as human body skin, subcutaneous tissue, fascia, blood vessel, nerve, muscle tendons, after wound healing, without the need to taking out.
embodiment 3a kind of medical operation suture thread, is prepared from by following main materials medicine, is weight portion (40g/ part): chitosan 52 parts, fibroin 32 parts, Folium Citri tangerinae 5 parts, Herba Stachydis Japonicae 4 parts, Herba Colei Pumili 6 parts, Radix Trichosanthis 8 parts, Lindera angustifolia Cheng 6 parts, Herba Agrimoniae 4 parts, Caulis et Folium fici Tikouae 7 parts, Herba Kummerowiae Striatae 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, Rhizoma et Radix Diphylleiae 6 parts.
A kind of preparation method of medical operation suture thread is:
(1) Pseudobulbus Bletillae (Rhizoma Bletillae) be placed in the concentration of 1.3 times amount be 0.5% Alumen water soak 2.0-hour, take out, load in water rice steamer, supreme gas is steamed in big fire, takes out while hot, dry, grinds to form fine powder; In Radix Trichosanthis, add the yellow wine of 0.22 times amount, mix thoroughly, after yellow wine is all absorbed, be placed on tile, slow fire roasting is to surface in yellow slightly focal spot, and taking-up cools, and is milled to fine powder, mixes with the Rhizoma Bletillae powder after process, crosses 60 mesh sieves, for subsequent use;
(2) Folium Citri tangerinae, Lindera angustifolia Cheng and Caulis et Folium fici Tikouae are mixed, the mature vinegar adding 2.4 times amount soaks 15 minutes, take out, together be placed in marmite with Herba Stachydis Japonicae, Herba Colei Pumili, Herba Agrimoniae, Herba Kummerowiae Striatae and Rhizoma et Radix Diphylleiae, add the redistilled water of 7.5 times of raw material doses, slow fire boiling twice, first time decocts 20 minutes, and second time decocts 13 minutes, merge twice decocting liquid, filter, in filtrate, add step (1) gained mixing fine powders, slow fire boiling 8 minutes, filter, filtrate reduced in volume, to 1/4 of original volume, obtains the concentrated liquid of tradition Chinese medicine, for subsequent use;
(3) chitosan is dissolved in the aqueous acetic acid of 2%, be mixed with the chitosan solution that concentration is 0.8%, gained chitosan solution mixes with step (2) gained the concentrated liquid of tradition Chinese medicine, add fibroin, the diffusant glycerol of 0.8% (diffusant to be mass fraction be) and the antibacterial Oleum Ricini of 1.1% (antibacterial to be mass fraction be), abundant stirring, after filtration, obtained spinning solution after deaeration, for subsequent use;
(4) by step (3) gained spinning solution through spinning pump metering, the aperture entered with eyelet is the spinning head of 0.07mm after metre filter, the spinning solution extruded from spinneret orifice solidifies for the first time through the sodium hydroxide/ethyl alcohol solution that temperature is 37 DEG C, carry out secondary through the distilled water of 14 DEG C again to solidify, make monofilament, for subsequent use;
(5) by after step (4) gained monofilament washing and drying, by the inside and outside stitching thread being twisted into various model, N 2the lower ethylene oxide sterilizing of protection, encapsulation, to obtain final product.
The using method of gained medical operation suture thread of the present invention is: for operation stitching, ligation etc. such as human body skin, subcutaneous tissue, fascia, blood vessel, nerve, muscle tendons, after wound healing, without the need to taking out.
typical case two: Song XX, man, 31 years old, people from Tai'an.Patient checks treatment on October 7th, 2013 because proctalgia comes my institute.Check: patient's hepatic portal pain is obvious, pain aggravation during stool, anus outer skin is rubescent, and touch a tender spot obviously in palpation hepatic portal rear, fluctuation is not obvious, is diagnosed as anal abscess.Abscess anal fistula incision and drainage is implemented after consultation of doctor and family numbers of patients are agreed to.A kind of medical operation suture thread of the present embodiment gained is used to sew up during operation stitching, 10 days are sewed up, there is not infection symptoms in suture, without pruritus, anaphylaxis, sew up after 30 days, wound heals substantially, without obviously sewing up sign, after 45 days, patient wound's skin recovers completely, without any stitching sign.
embodiment 4a kind of medical operation suture thread, is prepared from by following main materials medicine, is weight portion (30g/ part): chitosan 58 parts, fibroin 38 parts, Folium Citri tangerinae 6 parts, Herba Stachydis Japonicae 5 parts, Herba Colei Pumili 7 parts, Radix Trichosanthis 10 parts, Lindera angustifolia Cheng 8 parts, Herba Agrimoniae 6 parts, Caulis et Folium fici Tikouae 9 parts, Herba Kummerowiae Striatae 11 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 7 parts, Rhizoma et Radix Diphylleiae 8 parts.
A kind of preparation method of medical operation suture thread is:
(1) Pseudobulbus Bletillae (Rhizoma Bletillae) be placed in the concentration of 1.5 times amount be 0.5% Alumen water soak 2.4 hours, take out, load in water rice steamer, supreme gas is steamed in big fire, takes out while hot, dry, grinds to form fine powder; In Radix Trichosanthis, add the yellow wine of 0.28 times amount, mix thoroughly, after yellow wine is all absorbed, be placed on tile, slow fire roasting is to surface in yellow slightly focal spot, and taking-up cools, and is milled to fine powder, mixes with the Rhizoma Bletillae powder after process, crosses 70 mesh sieves, for subsequent use;
(2) Folium Citri tangerinae, Lindera angustifolia Cheng and Caulis et Folium fici Tikouae are mixed, the mature vinegar adding 3.2 times amount soaks 23 minutes, take out, together be placed in marmite with Herba Stachydis Japonicae, Herba Colei Pumili, Herba Agrimoniae, Herba Kummerowiae Striatae and Rhizoma et Radix Diphylleiae, add the redistilled water of 10.5 times of raw material doses, slow fire boiling twice, first time decocts 34 minutes, and second time decocts 17 minutes, merge twice decocting liquid, filter, in filtrate, add step (1) gained mixing fine powders, slow fire boiling 14 minutes, filter, filtrate reduced in volume, to 1/4 of original volume, obtains the concentrated liquid of tradition Chinese medicine, for subsequent use;
(3) chitosan is dissolved in the aqueous acetic acid of 2%, be mixed with the chitosan solution that concentration is 1.2%, gained chitosan solution mixes with step (2) gained the concentrated liquid of tradition Chinese medicine, add fibroin, the diffusant glycerol of 1.0% (diffusant to be mass fraction be) and the antibacterial Oleum Ricini of 1.4% (antibacterial to be mass fraction be), abundant stirring, after filtration, obtained spinning solution after deaeration, for subsequent use;
(4) by step (3) gained spinning solution through spinning pump metering, the aperture entered with eyelet is the spinning head of 0.10mm after metre filter, the spinning solution extruded from spinneret orifice solidifies for the first time through the sodium hydroxide/ethyl alcohol solution that temperature is 47 DEG C, carry out secondary through the distilled water of 22 DEG C again to solidify, make monofilament, for subsequent use;
(5) by after step (4) gained monofilament washing and drying, by the inside and outside stitching thread being twisted into various model, N 2the lower ethylene oxide sterilizing of protection, encapsulation, to obtain final product.
The using method of gained medical operation suture thread of the present invention is: for operation stitching, ligation etc. such as human body skin, subcutaneous tissue, fascia, blood vessel, nerve, muscle tendons, after wound healing, without the need to taking out.
embodiment 5a kind of medical operation suture thread, is prepared from by following main materials medicine, is weight portion (35g/ part): chitosan 55 parts, fibroin 35 parts, Folium Citri tangerinae 5.5 parts, Herba Stachydis Japonicae 4.5 parts, Herba Colei Pumili 6.5 parts, Radix Trichosanthis 9 parts, Lindera angustifolia Cheng 7 parts, Herba Agrimoniae 5 parts, Caulis et Folium fici Tikouae 8 parts, Herba Kummerowiae Striatae 10 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 6 parts, Rhizoma et Radix Diphylleiae 7 parts.
A kind of preparation method of medical operation suture thread is:
(1) Pseudobulbus Bletillae (Rhizoma Bletillae) be placed in the concentration of 1.4 times amount be 0.5% Alumen water soak 2.2 hours, take out, load in water rice steamer, supreme gas is steamed in big fire, takes out while hot, dry, grinds to form fine powder; In Radix Trichosanthis, add the yellow wine of 0.25 times amount, mix thoroughly, after yellow wine is all absorbed, be placed on tile, slow fire roasting is to surface in yellow slightly focal spot, and taking-up cools, and is milled to fine powder, mixes with the Rhizoma Bletillae powder after process, crosses 65 mesh sieves, for subsequent use;
(2) Folium Citri tangerinae, Lindera angustifolia Cheng and Caulis et Folium fici Tikouae are mixed, the mature vinegar adding 2.8 times amount soaks 20 minutes, take out, together be placed in marmite with Herba Stachydis Japonicae, Herba Colei Pumili, Herba Agrimoniae, Herba Kummerowiae Striatae and Rhizoma et Radix Diphylleiae, add the redistilled water of 9 times of raw material doses, slow fire boiling twice, first time decocts 27 minutes, and second time decocts 15 minutes, merge twice decocting liquid, filter, in filtrate, add step (1) gained mixing fine powders, slow fire boiling 11 minutes, filter, filtrate reduced in volume, to 1/4 of original volume, obtains the concentrated liquid of tradition Chinese medicine, for subsequent use;
(3) chitosan is dissolved in the aqueous acetic acid of 2%, be mixed with the chitosan solution that concentration is 1%, gained chitosan solution mixes with step (2) gained the concentrated liquid of tradition Chinese medicine, add fibroin, the diffusant glycerol of 0.9% (diffusant to be mass fraction be) and the antibacterial Oleum Ricini of 1.3% (antibacterial to be mass fraction be), abundant stirring, after filtration, obtained spinning solution after deaeration, for subsequent use;
(4) by step (3) gained spinning solution through spinning pump metering, the aperture entered with eyelet is the spinning head of 0.09mm after metre filter, the spinning solution extruded from spinneret orifice solidifies for the first time through the sodium hydroxide/ethyl alcohol solution that temperature is 42 DEG C, carry out secondary through the distilled water of 18 DEG C again to solidify, make monofilament, for subsequent use;
(5) by after step (4) gained monofilament washing and drying, by the inside and outside stitching thread being twisted into various model, N 2the lower ethylene oxide sterilizing of protection, encapsulation, to obtain final product.
The using method of gained medical operation suture thread of the present invention is: for operation stitching, ligation etc. such as human body skin, subcutaneous tissue, fascia, blood vessel, nerve, muscle tendons, after wound healing, without the need to taking out.
experimental example 1:the experimental study of a kind of medical operation suture thread (embodiment 5) of gained of the present invention:
1, external degradation experiment
Precision takes a kind of medical operation suture thread of a certain amount of gained of the present invention, by m(stitching thread): m(degraded solutions)=1:150 puts into constant temperature oscillator, temperature is regulated to be 37 DEG C, frequency of oscillation is 80 times/min, degraded solutions by mass fraction be 0.9% sodium chloride and mass fraction be that the aqueous solution of the ethylparaben of 0.04% is formed, and regulate pH to neutral through sodium hydroxide.Sample respectively at 3d, 5d, 7d, 10d, 20d, 30d, 40d, 50d, 60d, dehydrated alcohol dewaters 1 hour, 55 DEG C of vacuum dryings to constant weight, quality measurement loss rate.Mass loss rate=(W 0-W t)/W 0× 100%.Wherein W 0the quality before degraded, W tit is the quality after degraded different time.Result is as shown in table 1.
Note: "-" represents quality < 5g.
2, body absorption experiment
Get white mice 60, male and female half and half, body weight 180-200g, be evenly divided into experimental group and matched group at random, two groups of white mice no significant differences.Wherein experimental group uses a kind of medical operation suture thread of gained of the present invention to sew up white mice abdominal incision, matched group adopts PGLA absorbable suture (purchasing in Tianqing Biological Material Co., Ltd., Shanghai) to sew up white mice abdominal incision, then observes the absorbing state of two groups of stitching thread at 5d, 10d, 20d, 30d and 40d.Result is as shown in table 2.
Table 2: experimental group and the sutural body absorption result of matched group
3, interpretation of result
As shown in Table 1, a kind of medical operation suture thread of gained of the present invention is in 60d degradative phase, its quality reduces gently at front 7d, mass loss rate luffing is less, and after 10d, mass loss rate raises rapidly, degradation rate is accelerated, reach 77.58% at 50d mass loss rate, at the degrading quality < 5g of 60d, mass loss rate is now about 98% according to estimates.Demonstrate a kind of medical operation suture thread external degradation of gained of the present invention performance safety thus reliable.A kind of medical operation suture thread (experimental group) of gained of the present invention can absorb completely in vivo in 30d as shown in Table 2, and its body absorption successful is better than matched group.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. a medical operation suture thread, is characterized in that, is prepared from by following main materials medicine, be weight portion: chitosan 48-62, fibroin 30-40, Folium Citri tangerinae 4-7, Herba Stachydis Japonicae 3-6, Herba Colei Pumili 5-8, Radix Trichosanthis 7-11, Lindera angustifolia Cheng 5-9, Herba Agrimoniae 3-7, Caulis et Folium fici Tikouae 6-10, Herba Kummerowiae Striatae 8-12, Pseudobulbus Bletillae (Rhizoma Bletillae) 4-8, Rhizoma et Radix Diphylleiae 5-9.
2. a kind of medical operation suture thread as claimed in claim 1, is characterized in that, is prepared from by following main materials medicine, be weight portion: chitosan 52-58, fibroin 32-38, Folium Citri tangerinae 5-6, Herba Stachydis Japonicae 4-5, Herba Colei Pumili 6-7, Radix Trichosanthis 8-10, Lindera angustifolia Cheng 6-8, Herba Agrimoniae 4-6, Caulis et Folium fici Tikouae 7-9, Herba Kummerowiae Striatae 9-11, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-7, Rhizoma et Radix Diphylleiae 6-8.
3. a kind of medical operation suture thread as claimed in claim 1, is characterized in that, is prepared from by following main materials medicine, be weight portion: chitosan 55, fibroin 35, Folium Citri tangerinae 5.5, Herba Stachydis Japonicae 4.5, Herba Colei Pumili 6.5, Radix Trichosanthis 9, Lindera angustifolia Cheng 7, Herba Agrimoniae 5, Caulis et Folium fici Tikouae 8, Herba Kummerowiae Striatae 10, Pseudobulbus Bletillae (Rhizoma Bletillae) 6, Rhizoma et Radix Diphylleiae 7.
4. the preparation method of a kind of medical operation suture thread as described in as arbitrary in claim 1-3, it is characterized in that, step is as follows:
(1) Pseudobulbus Bletillae (Rhizoma Bletillae) be placed in the concentration of 1.2-1.6 times amount be 0.5% Alumen water soak 1.6-2.8 hour (concentration that preferred Pseudobulbus Bletillae (Rhizoma Bletillae) is placed in 1.3-1.5 times amount be 0.5% Alumen water soak 2.0-2.4 hour), take out, load in water rice steamer, supreme gas is steamed in big fire, take out while hot, drying, grinds to form fine powder; The yellow wine (preferably adding the yellow wine of 0.22-0.28 times amount in Radix Trichosanthis) of 0.18-0.32 times amount is added in Radix Trichosanthis, mix thoroughly, after yellow wine is all absorbed, be placed on tile, slow fire roasting is to surface in yellow slightly focal spot, and taking-up cools, be milled to fine powder, mix with the Rhizoma Bletillae powder after process, sieve for subsequent use;
(2) by Folium Citri tangerinae, Lindera angustifolia Cheng and Caulis et Folium fici Tikouae mixing, the mature vinegar adding 2.2-3.4 times amount soaks 13-25 minute (mature vinegar preferably adding 2.4-3.2 times amount soaks 15-23 minute), take out, with Herba Stachydis Japonicae, Herba Colei Pumili, Herba Agrimoniae, Herba Kummerowiae Striatae and Rhizoma et Radix Diphylleiae are together placed in marmite, add the redistilled water (preferably adding the redistilled water of 7.5-10.5 times of raw material dose) of 6.5-11.5 times of raw material dose, slow fire boiling twice, first time decocts 18-36 minute (preferably first time decocts 20-34 minute), second time decocts 10-20 minute (preferably second time decocts 13-17 minute), merge twice decocting liquid, filter, step (1) gained mixing fine powders is added in filtrate, slow fire boiling 6-16 minute (preferred slow fire boiling 8-14 minute), filter, filtrate reduced in volume is to 1/4 of original volume, obtain the concentrated liquid of tradition Chinese medicine, for subsequent use,
(3) chitosan is dissolved in the aqueous acetic acid of 2%, be mixed with the chitosan solution (being preferably mixed with the chitosan solution that concentration is 0.8-1.2%) that concentration is 0.5%-1.5%, gained chitosan solution mixes with step (2) gained the concentrated liquid of tradition Chinese medicine, add fibroin, diffusant and antibacterial, abundant stirring, after filtration, obtained spinning solution after deaeration, for subsequent use;
(4) step (3) gained spinning solution is entered after spinning pump metering, metre filter the spinning head with eyelet, the spinning solution extruded from spinneret orifice solidifies for the first time through sodium hydroxide/ethyl alcohol solution, carry out secondary through the distilled water of 10-26 DEG C again to solidify (preferably carrying out secondary through the distilled water of 14-22 DEG C again to solidify), make monofilament, for subsequent use;
(5) by after step (4) gained monofilament washing and drying, by the inside and outside stitching thread being twisted into various model, sterilizing, encapsulation, to obtain final product.
5. the preparation method of a kind of medical operation suture thread according to claim 4, is characterized in that, the middle 50-80 mesh sieve excessively of step (1) (preferred 60-70 mesh sieve excessively, mistake 65 mesh sieve be more preferably).
6. the preparation method of a kind of medical operation suture thread according to claim 4, it is characterized in that, the glycerol of to be mass fraction the be 0.7-1.1% of diffusant described in step (3) (glycerol of preferred described diffusant to be mass fraction be 0.8-1.0%, the described diffusant be more preferably to be mass fraction be 0.9% glycerol).
7. the preparation method of a kind of medical operation suture thread according to claim 4, it is characterized in that, in step (3) antibacterial to be mass fraction be 0.9-1.6% Oleum Ricini (Oleum Ricini of preferred antibacterial to be mass fraction be 1.1-1.4%, the antibacterial be more preferably to be mass fraction be 1.3% Oleum Ricini).
8. the preparation method of a kind of medical operation suture thread according to claim 4, it is characterized in that, in step (4), the temperature of sodium hydroxide/ethyl alcohol solution is 32-52 DEG C (temperature of preferred sodium hydroxide/ethyl alcohol solution is 37-47 DEG C, and the temperature of the sodium hydroxide/ethyl alcohol solution be more preferably is 42 DEG C).
9. the preparation method of a kind of medical operation suture thread according to claim 4, is characterized in that, the aperture of step (4) perforations is the aperture of the preferred eyelet of 0.05-0.12mm(is 0.07-0.10mm, and the aperture of the eyelet be more preferably is 0.09mm).
10. the preparation method of a kind of medical operation suture thread according to claim 4, is characterized in that, in step (5), sterilization method is N 2the lower ethylene oxide sterilizing of protection.
CN201510802365.0A 2015-11-19 2015-11-19 Medical surgical suture and preparation method thereof Pending CN105396170A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106319729A (en) * 2016-08-20 2017-01-11 杭州华盛实业有限公司 Jacquard fabric for bags and manufacturing method of jacquard fabric
CN106729946A (en) * 2016-11-25 2017-05-31 江苏爱西施科技服务咨询股份有限公司 A kind of silk suture with antibacterial anti hemorrhagic effect and preparation method thereof
CN106729944A (en) * 2016-11-25 2017-05-31 江苏爱西施科技服务咨询股份有限公司 A kind of fibroin albumen suture with easing pain and diminishing inflammation effect and preparation method thereof
CN111134747A (en) * 2019-12-31 2020-05-12 南通纺织丝绸产业技术研究院 Barb type silk suture line and preparation method thereof
CN111420115A (en) * 2019-01-26 2020-07-17 肖剑 Novel medical suture material and preparation method thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106319729A (en) * 2016-08-20 2017-01-11 杭州华盛实业有限公司 Jacquard fabric for bags and manufacturing method of jacquard fabric
CN106729946A (en) * 2016-11-25 2017-05-31 江苏爱西施科技服务咨询股份有限公司 A kind of silk suture with antibacterial anti hemorrhagic effect and preparation method thereof
CN106729944A (en) * 2016-11-25 2017-05-31 江苏爱西施科技服务咨询股份有限公司 A kind of fibroin albumen suture with easing pain and diminishing inflammation effect and preparation method thereof
CN111420115A (en) * 2019-01-26 2020-07-17 肖剑 Novel medical suture material and preparation method thereof
CN111134747A (en) * 2019-12-31 2020-05-12 南通纺织丝绸产业技术研究院 Barb type silk suture line and preparation method thereof

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Application publication date: 20160316