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CN105362778A - Traditional Chinese medicine composition for treating reflux gastritis and preparation method of traditional Chinese medicine composition - Google Patents

Traditional Chinese medicine composition for treating reflux gastritis and preparation method of traditional Chinese medicine composition Download PDF

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Publication number
CN105362778A
CN105362778A CN201510925651.6A CN201510925651A CN105362778A CN 105362778 A CN105362778 A CN 105362778A CN 201510925651 A CN201510925651 A CN 201510925651A CN 105362778 A CN105362778 A CN 105362778A
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chinese medicine
medicine composition
parts
traditional chinese
salviae miltiorrhizae
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李建敏
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/57Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/324Boswellia, e.g. frankincense
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a traditional Chinese medicine composition for treating reflux gastritis. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1-3 parts of American ginseng, 3-5 parts of belladonna herb, 8-10 parts of rhizoma phragmitis, 0.1-0.3 part of menthol, 6-8 parts of poria cocos, 8-12 parts of endothelium corneum gigeriae galli, 1-3 parts of radix salviae miltiorrhizae, and 3-5 parts of frankincense.

Description

A kind of Chinese medicine composition for the treatment of reflux gastritis and preparation method thereof
Technical field
The present invention relates to application and the preparation field of pharmaceuticals, relate to a kind of Chinese medicine composition for the treatment of reflux gastritis.
Background technology
Stomachache is also known as gastric abscess, refer to upper abdomen gastral cavilty portion nearly pit of the stomach place pain, the traditional Chinese medical science thinks that stomachache is that taste are impaired, the pain in gastral cavilty portion caused by qi and blood disorder, mainly with diseases caused by exogenous pathogenic factor cold-evil, the causes of disease such as the smooth and emptiness of spleen and stomach of injury due to diet, feelings will and causing, eating is pungent scorchingly adds dry weather, and stomach-fire is not fallen; The above abdominal pain such as acute gastritis, chronic gastritis, gastric ulcer, duodenal ulcer, functional digestive obstacle of doctor trained in Western medicine is cardinal symptom, belongs to Chinese medicine reflux gastritis scope.The method of current treatment reflux gastritis has Chinese traditional treatment and western medical treatment, western medical treatment is generally with amoxicillin+omeprazole+metronidazole, i.e. triple therapy, antacid infection is main, substantially can only alleviate or remove symptom, and long-term taking antibiotic, injure one's stomach gas, cause patient's anorexia, malnutrition, health is weaker.The traditional Chinese medical science is with cold and heat and asthenia and sthenia, coldheat complex, more common, but ignores taste prolonged deficiency, and long-pending silt is not smooth, only balances taste negative and positive not enough.Therefore cause unsatisfactory curative effect, Most patients feedback is only stomachache transference cure, but dietary amount does not increase, and digests and assimilates and do not improve.
Summary of the invention
One is the object of the present invention is to provide to treat stomachache, and the Chinese medicine composition that can improve appetite and digest and assimilate.
The present invention is achieved through the following technical solutions:
Treat a Chinese medicine composition for reflux gastritis, comprise the raw material of following weight portion: Radix Panacis Quinquefolii 1-3, Herba Belladonnae 3-5, Rhizoma Phragmitis 8-10, Mentholum 0.1-0.3, Poria 6-8, Endothelium Corneum Gigeriae Galli 8-12, Radix Salviae Miltiorrhizae 1-3, Olibanum 3-5.
Preferably, comprise the raw material of following weight portion: Radix Panacis Quinquefolii 2, Herba Belladonnae 4, Rhizoma Phragmitis 9, Mentholum 0.2, Poria 7, Endothelium Corneum Gigeriae Galli 10, Radix Salviae Miltiorrhizae 2, Olibanum 4.
The present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of reflux gastritis: comprise following process steps: the Radix Panacis Quinquefolii getting each weight portion by proportion relation, Herba Belladonnae, Rhizoma Phragmitis, Mentholum, Poria, Endothelium Corneum Gigeriae Galli, Radix Salviae Miltiorrhizae, Olibanum; Add 70% ethanol to soak 15 minutes at 60 ~ 65 DEG C, reflux, extract, 2-3 time, each 1 hour, 100 order filters filter, and obtain extracting solution; Merge extractive liquid, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; By concentrated solution in 70-100 DEG C of spraying dry or oven dry, be ground into 70-100 object fine powder, Conventional compression or encapsulated after granulating, to obtain final product.
Prescription of the present invention is exquisite, each component synergism, analgesia of releiving, clearing stomach spleen invigorating, and desilting helps digestion, especially applicable for gastric heat person with Spleen Deficiency.
Detailed description of the invention
Embodiment 1
(1) get Radix Panacis Quinquefolii 1 part, Herba Belladonnae 3 parts, Rhizoma Phragmitis 8 parts, Mentholum 0.1 part, 6 parts, Poria, Endothelium Corneum Gigeriae Galli 8 parts, Radix Salviae Miltiorrhizae 1 part, Olibanum 3 parts are for subsequent use;
(2) add 70% ethanol to soak 15 minutes at 60 DEG C, reflux, extract, 2 times, each 1 hour, 100 order filters filter, and obtain extracting solution; Merge extractive liquid, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; By concentrated solution in 70 DEG C of spraying dry or oven dry, be ground into 70 object fine powders, encapsulated after granulating, specification 0.45g/ grain. each 3 times of morning, noon and afternoon, bfore meals, each 3-5 grain.
Embodiment 2
(1) get Radix Panacis Quinquefolii 3 parts, Herba Belladonnae 5 parts, Rhizoma Phragmitis 10 parts, Mentholum 0.3 part, 8 parts, Poria, Endothelium Corneum Gigeriae Galli 12 parts, Radix Salviae Miltiorrhizae 3 parts, Olibanum 5 parts are for subsequent use;
(2) add 70% ethanol to soak 15 minutes at 65 DEG C, reflux, extract, 3 times, each 1 hour, 100 order filters filter, and obtain extracting solution; Merge extractive liquid, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; By concentrated solution in 100 DEG C of spraying dry or oven dry, be ground into 100 object fine powders, encapsulated after granulating, specification 0.45g/ grain.
Embodiment 3
(1) get Radix Panacis Quinquefolii 2 parts, Herba Belladonnae 4 parts, Rhizoma Phragmitis 9 parts, Mentholum 0.2 part, 7 parts, Poria, Endothelium Corneum Gigeriae Galli 10 parts, Radix Salviae Miltiorrhizae 2 parts, Olibanum 4 parts are for subsequent use;
(2) add 70% ethanol to soak 15 minutes at 62 DEG C, reflux, extract, 2 times, each 1 hour, 100 order filters filter, and obtain extracting solution; Merge extractive liquid, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; By concentrated solution in 80 DEG C of spraying dry or oven dry, be ground into 90 object fine powders, encapsulated after granulating, specification 0.45g/ grain.
Clinical efficacy data
1, the effect observation that has a stomach-ache is treated
1.1 objects: reflux gastritis observes 600 people, with gastralgia, hyperchlorhydria and the chronic dietary stagnation of QI, stool first hard rear half congealed, belch, stomach has burn feeling.
1.2 medicine compositions: Radix Panacis Quinquefolii 200 grams, Herba Belladonnae 400 grams, Rhizoma Phragmitis 900 grams, Mentholum 20 grams, 700 grams, Poria, Endothelium Corneum Gigeriae Galli 1000 grams, Radix Salviae Miltiorrhizae 200 grams, Olibanum 400 grams.
Said medicine is added 70% ethanol to soak 15 minutes at 62 DEG C, reflux, extract, 2 times, each 1 hour, 100 order filters filter, and obtain extracting solution; Merge extractive liquid, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; By concentrated solution in 80 DEG C of spraying dry or oven dry, be ground into 90 object fine powders, encapsulated after granulating, specification 0.45g/ grain, the morning, noon and afternoon are respectively once, bfore meals, each 3-5 grain.
1.3 curative effect judging standards:
Cure: gastralgia and other transference cures, x line, canel barium meal contrast examination or gastroscopy are normal.
Take a turn for the better: stomachache is alleviated, outbreak minimizing, other symptoms alleviate.
Do not heal: x line, canel barium meal contrast examination or gastroscopy are the same with premorbid, symptom is without improvement and take a turn for the better.
The routine effect for the treatment of stomachache 600
Use after 30 days, effective 478 examples of 600 example stomachache, take a turn for the better 104 examples, invalid 18 examples, obvious effective rate 80%, improvement rate 17%, total effective rate 97%.In use, all user all reflect that appetite improves, and appetite increases, and stool form and color make moderate progress.

Claims (3)

1. treat a Chinese medicine composition for reflux gastritis, it is characterized in that, comprise the raw material of following weight portion: Radix Panacis Quinquefolii 1-3, Herba Belladonnae 3-5, Rhizoma Phragmitis 6-8, Mentholum 0.1-0.3, Poria 6-8, Endothelium Corneum Gigeriae Galli 8-12, Radix Salviae Miltiorrhizae 1-3, Olibanum 3-5.
2. a kind of Chinese medicine composition for the treatment of reflux gastritis according to claim 1, is characterized in that, comprise the raw material of following weight portion: Radix Panacis Quinquefolii 2, Herba Belladonnae 4, Rhizoma Phragmitis 9, Mentholum 0.2, Poria 7, Endothelium Corneum Gigeriae Galli 10, Radix Salviae Miltiorrhizae 2, Olibanum 4.
3. a kind of preparation method for the treatment of the Chinese medicine composition of reflux gastritis according to claim 1 and 2: it is characterized in that comprising following process steps: the Radix Panacis Quinquefolii getting each weight portion by proportion relation, Herba Belladonnae, Rhizoma Phragmitis, Mentholum, Poria, Endothelium Corneum Gigeriae Galli, Radix Salviae Miltiorrhizae, Olibanum; Add 70% ethanol to soak 15 minutes at 60 ~ 65 DEG C, reflux, extract, 2-3 time, each 1 hour, 100 order filters filter, and obtain extracting solution; Merge extractive liquid, reclaim under reduced pressure in input concentrating under reduced pressure tank, ethanol, to without alcohol taste, obtains concentrated solution; By concentrated solution in 70-100 DEG C of spraying dry or oven dry, be ground into 70-100 object fine powder, Conventional compression or encapsulated after granulating, to obtain final product.
CN201510925651.6A 2015-12-14 2015-12-14 Traditional Chinese medicine composition for treating reflux gastritis and preparation method of traditional Chinese medicine composition Pending CN105362778A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106075158A (en) * 2016-08-10 2016-11-09 李建敏 A kind of Chinese medicine composition treating acute simple gastritis and preparation method thereof
CN106138533A (en) * 2016-08-10 2016-11-23 李建敏 A kind of Chinese medicine composition treating flatulence pain and preparation method thereof
CN106177645A (en) * 2016-08-10 2016-12-07 李建敏 A kind of Chinese medicine composition treating chronic gastritis and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102309585A (en) * 2010-06-30 2012-01-11 丰建萍 Chinese medicinal preparation for treating gastrosis
CN102793862A (en) * 2011-05-24 2012-11-28 董玺 Formula of Chinese medicine for treating bile reflux gastritis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102309585A (en) * 2010-06-30 2012-01-11 丰建萍 Chinese medicinal preparation for treating gastrosis
CN102793862A (en) * 2011-05-24 2012-11-28 董玺 Formula of Chinese medicine for treating bile reflux gastritis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
贾润苗: "浅谈中医治疗胆汁反流性胃炎", 《河南中医》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106075158A (en) * 2016-08-10 2016-11-09 李建敏 A kind of Chinese medicine composition treating acute simple gastritis and preparation method thereof
CN106138533A (en) * 2016-08-10 2016-11-23 李建敏 A kind of Chinese medicine composition treating flatulence pain and preparation method thereof
CN106177645A (en) * 2016-08-10 2016-12-07 李建敏 A kind of Chinese medicine composition treating chronic gastritis and preparation method thereof

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Application publication date: 20160302