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CN105342939A - Disinfectant bath wash capable of reducing operative incision infection and preparation technology of disinfectant bath wash - Google Patents

Disinfectant bath wash capable of reducing operative incision infection and preparation technology of disinfectant bath wash Download PDF

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Publication number
CN105342939A
CN105342939A CN201510931588.7A CN201510931588A CN105342939A CN 105342939 A CN105342939 A CN 105342939A CN 201510931588 A CN201510931588 A CN 201510931588A CN 105342939 A CN105342939 A CN 105342939A
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China
Prior art keywords
bath foam
disinfectant
sterilization bath
agent
infection according
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201510931588.7A
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Chinese (zh)
Inventor
王金强
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Shandong Doctor That Disappears Sterilizes Science And Technology Co Ltd
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Shandong Doctor That Disappears Sterilizes Science And Technology Co Ltd
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Priority to CN201510931588.7A priority Critical patent/CN105342939A/en
Publication of CN105342939A publication Critical patent/CN105342939A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/722Chitin, chitosan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/43Guanidines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/736Chitin; Chitosan; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention discloses disinfectant bath wash capable of reducing operative incision infection and a preparation technology of the disinfectant bath wash. The disinfectant bath wash is prepared from the following components in percentage by mass: 0.2 percent to 3 percent of disinfectant, 0.01 percent to 13 percent of collaborative sterilant, 2 percent to 10 percent of surfactant, 0.01 percent to 2 percent of humectant, 0.5 percent to 20 percent of thickener, 0.01 percent to 2 percent of acidity regulator and the balance of water. According to the disinfectant bath wash disclosed by the invention, chlorhexidine gluconate is selected as a main disinfection component of the disinfectant bath wash, the probability of the surgical operative incision infection is reduced, and bacterial resisting and inhibiting can be continuously carried out on an operative incision.

Description

Sterilization bath foam and the preparation technology thereof of surgery cut infection can be reduced
Technical field
The invention belongs to disinfectant solution preparing technical field, be specifically related to a kind of the sterilization bath foam and the preparation technology thereof that reduce surgery cut infection.
Background technology
Surgical site infection (SSI) refers to without postoperative 30 days of implant, and have the implant infection relevant with operation that be that occur in postoperative 1 year, comprise surgery cut infection, adjacent organ and lacuna infect.SSI is one of postoperative modal complication, occupies the 3rd of hospital infection, accounts for the 14%-16% of nosocomial infections of inpatients.The method reducing postoperative wound infection has a lot, and wherein preoperative use is reduce the directly the easiest method of surgery cut infection containing the sterilization bath foam shower of chlorhexidine gluconate.
According to relevant, chlorhexidine gluconate disinfectant solution continuous skin antibacterial time sustainable 192h, the zest of chlorhexidine gluconate is little compared with chlorhexidine acetate, good stability.Preoperative use 2% chlorhexidine gluconate is extremely important, should clean patient skin before surgical sterilizing, removes dirt and reduces quantity in bacterium as far as possible, prophylaxis of microbial can move to operative region.
Summary of the invention
The invention provides a kind of the sterilization bath foam and the preparation technology thereof that reduce surgery cut infection, with prevention and corntrol surgical site infection problem.
The technical solution adopted for the present invention to solve the technical problems is:
Reduce a sterilization bath foam for surgery cut infection, be made up of disinfectant, Synergistic biocidal agent, surfactant, wetting agent, thickening agent, acidity regulator and water, wherein the service property (quality) percentage ratio of each component is disinfectant 0.2%-3%; Synergistic biocidal agent 0.01%-13%; Surfactant 2%-10%; Wetting agent 0.01%-2%; Thickening agent 0.5%-20%; Acidity regulator 0.01%-2%; Surplus is water.
Above-mentioned disinfectant is chlorhexidine gluconate, chlorhexidine acetate, triclosan, polyhexamethylene guanidine or poly hexamethylene biguanide, first-selected chlorhexidine gluconate.
Above-mentioned Synergistic biocidal agent is carboxymethyl chitosan.
Above-mentioned surfactant is fatty alcohol-polyoxyethylene ether, polyol ester, polyol ester polyoxyethylene ether or alkyl polyglucoside, and first-selected alkyl polyglucoside is as surfactant.
Above-mentioned wetting agent is vitamin E, propylene glycol, glycerol, Polyethylene Glycol, hyaluronic acid or Aloe, first-selected Aloe.
Above-mentioned thickening agent is CMC, thickening agent 638, thickening agent 658 or compound recipe thickening agent 698, first-selected compound recipe thickening agent 698.
Above-mentioned acidity regulator is lactic acid, malic acid or citric acid, first-selected citric acid.
The present invention sterilizes in body wash liquid formula:
Chlorhexidine gluconate: chlorhexidine has another name called chlorhexidine is biguanides disinfectant, is the safe disinfection agent that a kind of toxicity, corrosivity and zest are all very low.For external broad-spectrum antibacterial, bactericide, all have very strong antibacterial, sterilizing ability to Gram-negative and gram-positive bacterium, be a kind of cationic germicide, stock solution is 20% aqueous solution.
Carboxymethyl chitosan is one of higher derivative of chitosan, is obtained in the basic conditions by chitosan with chloroacetate reaction.Carboxymethyl chitosan is a kind of polyampholyte, has good water solublity, film property, moisturizing water-retaining property, antibiotic property and extremely strong heavy metal chelating effect.Carboxymethyl chitosan performance of keeping humidity is good, and its performance of keeping humidity and hyaluronic acid are quite, all highly stable within the scope of PH widely.Carboxymethyl chitosan does not have Intradermal zest, does not have cytotoxicity, possesses good biological safety.Adding carboxymethyl chitosan in this product can coordinate chlorhexidine gluconate collaborative anti-antibacterial, makes the anti-antibacterial time longer;
Alkyl polyglucoside is as a kind of environmental protection surfactant being derived from renewable plant material, nontoxic, gentle, do not stimulate, fully biodegradable.Alkyl polyglucoside is non-stimulated to eyes, have soft effect to skin, and its advantage is: foaming characteristic is good, and foaming abundancy is fine and smooth.Safety, thickening, thickening, detergency are remarkable.Alkyl polyglucoside has the antibacterial activity of wide spectrum, and to gram negative bacteria, positive bacteria and fungus, alkyl polyglucoside has antibacterial activity;
Compound recipe thickening agent 698, this product is nontoxic, non-irritating non-ionic surface active agent, and thickening properties is good, can the non-ionic surface active agent such as APG composite, there is excellent foaming power, washing force and sterilizing power;
Aloe: vegetal wetting agent, because Aloe juice contains mucopolysaccharide (being similar to hyaluronic acid), therefore has well lubrication and moisture-keeping function
The above-mentioned preparation technology reducing the sterilization bath foam of surgery cut infection, concrete steps, for getting Purified Water q. s in emulsion tank, are heated to 35 DEG C-40 DEG C, add surfactant and stir 20 minutes, be then cooled to room temperature.Add disinfectant and Synergistic biocidal agent, stir 15 minutes, add thickening agent, stir 20 minutes, measure the pH value of solution, slowly add acidity regulator, make the pH value of solution be 6-7, finally add wetting agent extracting solution and stir 20 minutes, can reduce the sterilization bath foam of operative incision.
Sterilization bath foam of the present invention select glucose saccharic acid chlorhexidine as sterilization bath foam main disinfection composition, reduce the probability of infected surgical incisions in nine, can to operation cutting part continue carry out anti-antibacterial.
Detailed description of the invention
Reduce a sterilization bath foam for surgery cut infection, be made up of disinfectant, Synergistic biocidal agent, surfactant, wetting agent, thickening agent, acidity regulator and water, wherein the service property (quality) percentage ratio of each component is disinfectant 0.2%-3%; Synergistic biocidal agent 0.01%-13%; Surfactant 2%-10%; Wetting agent 0.01%-2%; Thickening agent 0.5%-20%; Acidity regulator 0.01%-2%; Surplus is water.
Above-mentioned disinfectant is chlorhexidine gluconate, chlorhexidine acetate, triclosan, polyhexamethylene guanidine or poly hexamethylene biguanide, first-selected chlorhexidine gluconate.
Above-mentioned Synergistic biocidal agent is carboxymethyl chitosan.
Above-mentioned surfactant is fatty alcohol-polyoxyethylene ether, polyol ester, polyol ester polyoxyethylene ether or alkyl polyglucoside, and first-selected alkyl polyglucoside is as surfactant.
Above-mentioned wetting agent is vitamin E, propylene glycol, glycerol, Polyethylene Glycol, hyaluronic acid or Aloe, first-selected Aloe.
Above-mentioned thickening agent is CMC, thickening agent 638, thickening agent 658 or compound recipe thickening agent 698, first-selected compound recipe thickening agent 698.
Above-mentioned acidity regulator is lactic acid, malic acid or citric acid, first-selected citric acid.
The present invention sterilizes in body wash liquid formula:
Chlorhexidine gluconate: be a kind of cationic germicide is 20% aqueous solution;
Carboxymethyl chitosan is one of higher derivative of chitosan, is obtained in the basic conditions by chitosan with chloroacetate reaction.Carboxymethyl chitosan is a kind of polyampholyte, has good water solublity, film property, moisturizing water-retaining property, antibiotic property and extremely strong heavy metal chelating effect.Carboxymethyl chitosan performance of keeping humidity is good, and its performance of keeping humidity and hyaluronic acid are quite, all highly stable within the scope of PH widely.Carboxymethyl chitosan does not have Intradermal zest, does not have cytotoxicity, possesses good biological safety.Adding carboxymethyl chitosan in this product can coordinate chlorhexidine gluconate collaborative anti-antibacterial, makes the anti-antibacterial time longer;
Alkyl polyglucoside is as a kind of environmental protection surfactant being derived from renewable plant material, nontoxic, gentle, do not stimulate, fully biodegradable.Alkyl polyglucoside is non-stimulated to eyes, have soft effect to skin, and its advantage of A is: foaming characteristic is good, and foaming abundancy is fine and smooth.Safety, thickening, thickening, detergency are remarkable.Alkyl polyglucoside has the antibacterial activity of wide spectrum, and to gram negative bacteria, positive bacteria and fungus, alkyl polyglucoside has antibacterial activity;
Compound recipe thickening agent 698, this product is nontoxic, non-irritating non-ionic surface active agent, and thickening properties is good, can the non-ionic surface active agent such as APG composite, there is excellent foaming power, washing force and sterilizing power;
Aloe: vegetal wetting agent, because Aloe juice contains mucopolysaccharide (being similar to hyaluronic acid), therefore has well lubrication and moisture-keeping function
The above-mentioned sterilization bath foam reducing surgery cut infection, concrete steps, for getting Purified Water q. s in emulsion tank, are heated to 35 DEG C-40 DEG C, add Surfactants Alkyl and stir 20 minutes, be then cooled to room temperature.Add disinfectant chlorhexidine gluconate, stir 15 minutes, add compound recipe thickening agent 698, stir 20 minutes, measure the pH value of solution, slowly add acidity regulator citric acid, make the pH value of solution be 6-7, finally add wetting agent Aloe extraction solution and stir 20 minutes, can reduce the sterilization bath foam of operative incision.

Claims (14)

1. one kind can be reduced the sterilization bath foam of surgery cut infection, it is characterized in that being made up of disinfectant, Synergistic biocidal agent, surfactant, wetting agent, thickening agent, acidity regulator and water, wherein the service property (quality) percentage ratio of each component is disinfectant 0.2%-3%; Synergistic biocidal agent 0.01%-13%; Surfactant 2%-10%; Wetting agent 0.01%-2%; Thickening agent 0.5%-20%; Acidity regulator 0.01%-2%; Surplus is water.
2. the sterilization bath foam reducing surgery cut infection according to claim 1, is characterized in that disinfectant is chlorhexidine gluconate, chlorhexidine acetate, triclosan, polyhexamethylene guanidine or poly hexamethylene biguanide, first-selected chlorhexidine gluconate.
3. the sterilization bath foam reducing surgery cut infection according to claim 1, is characterized in that Synergistic biocidal agent is carboxymethyl chitosan.
4. the sterilization bath foam reducing surgery cut infection according to claim 1, is characterized in that surfactant is fatty alcohol-polyoxyethylene ether, polyol ester, polyol ester polyoxyethylene ether or alkyl polyglucoside.
5. the sterilization bath foam reducing surgery cut infection according to claim 1, is characterized in that wetting agent is vitamin E, propylene glycol, glycerol, Polyethylene Glycol, hyaluronic acid or Aloe.
6. the sterilization bath foam reducing surgery cut infection according to claim 1, is characterized in that thickening agent is CMC, thickening agent 638, thickening agent 658 or compound recipe thickening agent 698.
7. the sterilization bath foam reducing surgery cut infection according to claim 1, is characterized in that acidity regulator is lactic acid, malic acid or citric acid.
8. the sterilization bath foam reducing surgery cut infection according to claim 2, is characterized in that disinfectant is chlorhexidine gluconate.
9. the sterilization bath foam reducing surgery cut infection according to claim 4, is characterized in that surfactant is alkyl polyglucoside.
10. the sterilization bath foam reducing surgery cut infection according to claim 5, is characterized in that wetting agent is Aloe.
The 11. sterilization bath foam reducing surgery cut infection according to claim 6, is characterized in that thickening agent is compound recipe thickening agent 698.
The 12. sterilization bath foam reducing surgery cut infection according to claim 7, is characterized in that acidity regulator is citric acid.
13. preparation methoies reducing the sterilization bath foam of surgery cut infection according to claim 1, is characterized in that getting Purified Water q. s in emulsion tank, heat to 35 DEG C-40 DEG C, add surfactant and stir 20 minutes, be then cooled to room temperature.
14. add disinfectant and Synergistic biocidal agent, stir 15 minutes, add thickening agent, stir 20 minutes, measure the pH value of solution, slowly add acidity regulator, make the pH value of solution be 6-7, finally add wetting agent extracting solution and stir 20 minutes, can reduce the sterilization bath foam of operative incision.
CN201510931588.7A 2015-12-15 2015-12-15 Disinfectant bath wash capable of reducing operative incision infection and preparation technology of disinfectant bath wash Pending CN105342939A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106267381A (en) * 2016-07-12 2017-01-04 东莞市万佳医疗科技有限公司 Body cavity imports lubricating fluid and preparation method thereof
CN108578272A (en) * 2018-04-19 2018-09-28 山东顺皓聚氨酯保温材料有限公司 A kind of polyhexamethylene guanide/biguanide hydrochloride shower cream and preparation method thereof
WO2019025599A1 (en) * 2017-08-04 2019-02-07 Laboratorios Kin, S.A. Gel comprising chlorhexidine
CN109529025A (en) * 2018-11-26 2019-03-29 浙江舒是生物科技有限公司 A kind of medical cosmetology Special sterilizing liquid
CN111643519A (en) * 2020-06-29 2020-09-11 华仁药业股份有限公司 Wound disinfectant and preparation method thereof

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Publication number Priority date Publication date Assignee Title
CN102091097A (en) * 2011-01-28 2011-06-15 武汉耦合医学科技有限责任公司 Washing-free puerpera perineum medical-care gel and preparation method thereof
CN102100650A (en) * 2011-01-28 2011-06-22 武汉耦合医学科技有限责任公司 Gel medical supply for preventing bedsore and preparation method thereof
CN102107013A (en) * 2011-01-28 2011-06-29 武汉耦合医学科技有限责任公司 Sterile ultrasound gel for invasive ultrasound diagnosis and treatment and preparation method thereof
CN103271834A (en) * 2013-06-18 2013-09-04 中国日用化学工业研究院 Non-irritant pollution-free moisturizing pearly lustre bath foam and preparation method thereof
CN104784164A (en) * 2015-03-13 2015-07-22 天津司邦适生物科技股份有限公司 Protein-based skin cleaning disinfectant and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102091097A (en) * 2011-01-28 2011-06-15 武汉耦合医学科技有限责任公司 Washing-free puerpera perineum medical-care gel and preparation method thereof
CN102100650A (en) * 2011-01-28 2011-06-22 武汉耦合医学科技有限责任公司 Gel medical supply for preventing bedsore and preparation method thereof
CN102107013A (en) * 2011-01-28 2011-06-29 武汉耦合医学科技有限责任公司 Sterile ultrasound gel for invasive ultrasound diagnosis and treatment and preparation method thereof
CN103271834A (en) * 2013-06-18 2013-09-04 中国日用化学工业研究院 Non-irritant pollution-free moisturizing pearly lustre bath foam and preparation method thereof
CN104784164A (en) * 2015-03-13 2015-07-22 天津司邦适生物科技股份有限公司 Protein-based skin cleaning disinfectant and preparation method thereof

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106267381A (en) * 2016-07-12 2017-01-04 东莞市万佳医疗科技有限公司 Body cavity imports lubricating fluid and preparation method thereof
WO2019025599A1 (en) * 2017-08-04 2019-02-07 Laboratorios Kin, S.A. Gel comprising chlorhexidine
CN110996891A (en) * 2017-08-04 2020-04-10 实验室金公司 Gel comprising chlorhexidine
CN110996891B (en) * 2017-08-04 2023-02-28 实验室金公司 Gel comprising chlorhexidine
CN108578272A (en) * 2018-04-19 2018-09-28 山东顺皓聚氨酯保温材料有限公司 A kind of polyhexamethylene guanide/biguanide hydrochloride shower cream and preparation method thereof
CN109529025A (en) * 2018-11-26 2019-03-29 浙江舒是生物科技有限公司 A kind of medical cosmetology Special sterilizing liquid
CN111643519A (en) * 2020-06-29 2020-09-11 华仁药业股份有限公司 Wound disinfectant and preparation method thereof

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Application publication date: 20160224