CN105288272A - Formula for treating uremia and preparation method - Google Patents
Formula for treating uremia and preparation method Download PDFInfo
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- CN105288272A CN105288272A CN201510714742.5A CN201510714742A CN105288272A CN 105288272 A CN105288272 A CN 105288272A CN 201510714742 A CN201510714742 A CN 201510714742A CN 105288272 A CN105288272 A CN 105288272A
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Abstract
The invention discloses a formula for treating uremia and a preparation method. The formula is mainly prepared from, by weight, 8-13 parts of cassia twigs, 10-14 parts of bitter bamboo leaves, 7-15 parts of ramose scouring rush herbs, 6-12 parts of cavalerie fevervine, 4-9 parts of flos rosae rugosae, 6-10 parts of devilpepper roots, 8-12 parts of salvia miltiorrhiza roots, 10-15 parts of stellaria yunnanensis, 7-13 parts of phyllanthus urinaria, 9-12 parts of cymbopogon flowers, 6-11 parts of radix achyranthis bidentatae, 5-10 parts of magnolia coco, 3-8 parts of clovetree twigs and 7-14 parts of gold stargrass herbs. According to the formula for treating the uremia and the preparation method, through functions of integrally regulating and improving the habitus, enhancing the disease preventing and resisting capacities, preserving the residual kidney and the like, blood circulation can be promoted, complete excretion of metabolites such as toxins can be promoted, the toxic symptom of the whole body disappears accordingly, the treatment effect is exact, and the effect is significant.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to one and treat uremic prescription and preparation method.
Background technology
Uremia is a kind of commonly encountered diseases.The traditional Chinese medical science is divided in pyretic toxicity uremia 8 large types such as accumulateing type, damp-heat gluing each other type, liver-stomach disharmony type, insufficiency of the spleen phlegm stagnation syndrome type according to dialectical, for different typings, takes different therapeutic rules, to delay the process of renal failure, improves symptom.According to the feature of uremia's state of an illness complexity, usually a point following pattern of syndrome gives determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs: accumulate type in pyretic toxicity: demonstrate,prove to generate heat, the contact of aversion to cold, aversion to heat, and cough, pharyngalgia are feature.Control with heat-clearing and toxic substances removing.Damp-heat gluing each other type: demonstrate,prove to generate heat, aversion to cold, very, or popular drama at nightfall, daybreak obtains antiperspirant and separates as feature afternoon heat.Control to remove damp and clearing heat, side cuts out by haoqin qingdan decoctionization.Liver-stomach disharmony type: demonstrate,prove with epigastric oppression swollen, Nausea and vomiting, lack of appetite are indigestion and loss of appetite, singultus heating installation is feature.Control with soothing liver-QI stomach function regulating, help with stomach warming preventing or arresting vomiting.Insufficiency of the spleen phlegm stagnation syndrome type: demonstrate,prove, lack of appetite poor appetite dull with abdominal distention, tastelessness, feel sick, defecate not well or have cough, tell rare clearly expectorant for feature.Control with invigorating the spleen and regulating the stomach, help to reduce phlegm pure and impure, side closes with Liujunzi Tang and adjusts stomach CHENGQI TANGization to cut out.Spleen deficiency and blood stasis type: disease sees abdominal distention and little diet, or have nauseating or retch, large constipation or not well, limb is soft unable, shallow complexion, and pale tongue is dark, or there is petechia on tongue limit.Control with spleen invigorating purging FU-organs, help with nourshing blood and promoting blood circulation, square decoction of four noble drugs, warming the spleen close TAOHONG SIWU TANGization and cut out.Kidney deficiency blood stasis type: disease sees that aversion to cold is afraid of cold, hands and feet being not warm, lusterless complexion; Spiritlessness and weakness, defecates not well, time and feel sick, pale tongue is dark, and there is petechia on tongue limit.Control and dispel with the kidney warming turbid, help with blood circulation promoting and blood stasis dispelling, square Yougui Yin, the kidney-Yang-Reinkforcing Decotion, danggui sini decoction close TAOHONG SIWU TANGization and cut out.Yang deficiency blood stasis type: disease meeting limb edema, press as mud, not easily put down again, complexion white, deficiency of QI with disinclination to talk, oliguria is smooth, and pale tongue is dark, while there is petechia.Control with warming YANG to promote diuresis, helping to invigorate blood circulation, it is turbid to dispel, and square Zhen Wu Tang, Decoction for strengthening the Spleen-Yang, WUPI YIN are closed TAOHONG SIWU TANGization and cut out.Yang deficiency of spleen and stomache: disease sees that aversion to cold tiredly to crouch, is afraid of cold, and face lip is white, do during abdominal distention to feel sick and retch, spue clear water sputum sometimes, defecates not well.Control with warming and recuperating the spleen and kidney, side's pieces of Jin ' gui shenqi soup, lizhong decoction.
Application publication number CN103690807A(application number 201310688110.7) Chinese patent literature disclose one and treat uremic Chinese medicine, it is made up of the crude drug of following weight: Herba Epimedii 30g, Cortex Phellodendri 12g, Caulis Perillae 10g, Radix Clematidis 6g, Rhizoma Imperatae 20g, Fructus Psoraleae 15g, Radix Salviae Miltiorrhizae 15g, Rhizoma Alismatis 20g, Fructus Rubi 12g, Ramulus Uncariae Cum Uncis 9g, Herba Cistanches 15g, Semen Lepidii (Semen Descurainiae) 20g, Radix Ophiopogonis 10g, Herba Ecliptae 12g, Herba Plantaginis 10g, Indigo Naturalis 6g, Herba Ephedrae 10g, Fructus Lycii 10g, Radix Polygoni Multiflori 6g.Application publication number CN104173666A(application number 201410419681.5) Chinese patent literature disclose one and treat uremic medicine, it is made up of Radix Et Rhizoma Rhei 250g, Semen Plantaginis 300g, RHIIZOMA DIOSCOREAE fr0m Henan of China 600g, Radix Cirsii Japonici 200g, Galla Chinensis 200g, Herba Lobeliae Chinensis 200g, Fructus Toosendan 100g, Folium Isatidis 300g, Ramulus Cinnamomi 100g, Fructus Psoraleae 300g, Radix Linderae 200g, Radix Panacis Quinquefolii 200g, Semen Pharbitidis 200g, Radix Polygalae 300g, Radix Rehmanniae 500g, Carapax Trionycis 250g, Flos Lonicerae 1000g, Rhizoma Coptidis 200g.Application publication number CN104606440A(application number 201510081553.9) Chinese patent literature disclose one and treat uremic Chinese medicine, its active component is prepared from by the raw material of following weight proportion: Radix Rehmanniae 24-25g, Rhizoma Atractylodis Macrocephalae 12-15g, cattle sunset 15-20g, Radix Paeoniae Alba 15-20g, Semen Plantaginis 20g, Poria 15g, Rhizoma Alismatis 0-15g, Cortex Eucommiae 0-30g, Fructus Psoraleae 0-24g, Fructus Lycii 0-20g, Semen Platycladi 0-25g, Rhizoma dioscoreae 0-15g, Radix Panacis Quinquefolii 0-30g, Cortex Moutan 0-20g, Semen Cuscutae 0-18g, Radix Angelicae Sinensis 0-25g, Radix Codonopsis 0-15g, Rhizoma Cyperi 0-15g, Rhizoma Anemarrhenae 0-15g, Rhizoma Chuanxiong 0-12g, Radix Dipsaci 0-15g, Rhizoma Zingiberis Recens 0-10g, Radix Glycyrrhizae 0-3g, Fructus Chaenomelis 0-20g, Folium Perillae 0-15g, Pericarpium Citri Reticulatae 0-15g.
Dialysis is main, the effective treatment means of uremic patient, but dialysis treatment itself also has some negative effects, such as: add center of gravity, lung, the going down of brain function, affect hemodynamic stability, have additional nutrients the loss of composition, causes the unbalance etc. of various element in body.Dialysis can extend patient's life-span to a certain extent, but thoroughly can not remove the toxin in patient body, stop dialysis namely rebounding, and medical expense is higher.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide one and treat uremic prescription and preparation method.The present invention has no side effect, do not rebound, medical expense is lower, improves body constitution, strengthen disease resistance ability by entirety conditioning, can be gone directly after active Chinese drug component material enters human body nephropathy stove fast, combine closely with various virulence factors such as causing nephritoxic factor, and carry out strong attack to it, it is broken, cracking is also thoroughly removed, block kidney to continue to worsen, preserve the functions such as remnant kidney; Can blood circulation promoting, promote the abundant excretion of the metabolites such as toxin, systemic toxicity profiles symptom disappears thereupon.
Technical scheme of the present invention is:
Treat uremic prescription, take off the primary raw material medicine stating weight proportion and be prepared from: Ramulus Cinnamomi 8-13, Folium Pleioblasti 10-14, Herba equiseti ramosissimi 7-15, tomentose fevervine herb 6-12, Flos Rosae Rugosae 4-9, Radix Rauvolfiae 6-10, Radix Salviae Miltiorrhizae 8-12, Radix Stellariae Yunnanensis 10-15, Cacumen Securinegae Suffruticosae 7-13, Herba Cymbopogonis Citrari 9-12, Radix Achyranthis Bidentatae 6-11, Flos Magnoliae Cocinis 5-10, Caulis Caryophylli 3-8, Herba hypoxis aureae 7-14.
Treat uremic prescription, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Ramulus Cinnamomi 9-12, Folium Pleioblasti 11-13, Herba equiseti ramosissimi 9-12, tomentose fevervine herb 8-11, Flos Rosae Rugosae 5-8, Radix Rauvolfiae 7-9, Radix Salviae Miltiorrhizae 9-11, Radix Stellariae Yunnanensis 12-14, Cacumen Securinegae Suffruticosae 9-12, Herba Cymbopogonis Citrari 10-11, Radix Achyranthis Bidentatae 8-10, Flos Magnoliae Cocinis 7-9, Caulis Caryophylli 4-7, Herba hypoxis aureae 8-11.
Treat uremic prescription, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Ramulus Cinnamomi 10, Folium Pleioblasti 12, Herba equiseti ramosissimi 11, tomentose fevervine herb 10, Flos Rosae Rugosae 7, Radix Rauvolfiae 8, Radix Salviae Miltiorrhizae 10, Radix Stellariae Yunnanensis 13, Cacumen Securinegae Suffruticosae 11, Herba Cymbopogonis Citrari 10.5, Radix Achyranthis Bidentatae 9, Flos Magnoliae Cocinis 8, Caulis Caryophylli 6, Herba hypoxis aureae 9.
Present invention also offers the preparation method uremic for aforementioned therapies prescription being made pharmaceutically acceptable pill, capsule, granule and tablet.
The preparation method of described pill is:
(1) Herba equiseti ramosissimi is put into 55 DEG C of baking ovens, dry 12 hours, take out, be ground into fine powder, cross No. five sieves, soak 1.5-2.5 hour (preferably soaking 2 hours), amount of water is 3.2-4.6 times (preferred amount of water is 4.2 times of Herba equiseti ramosissimi fine powder weight) of Herba equiseti ramosissimi fine powder weight, be heated to 70 DEG C, and stirring makes into pasty state, for subsequent use;
(2) Folium Pleioblasti, Flos Rosae Rugosae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is the 4.3-6 of three taste crude drug gross weights doubly (preferred amount of water is 5 times of three taste crude drug gross weights), each decoction 15-25 minute (preferably each decoction 20 minutes), merges twice medicinal liquid;
(3) Radix Salviae Miltiorrhizae is dropped in pot, fry 8-12 minute (preferably frying 10 minutes with slow fire) with slow fire, take out, cool;
(4) step (3) gained and all the other the 9 taste crude drug except Folium Pleioblasti, Herba equiseti ramosissimi, Flos Rosae Rugosae, Radix Salviae Miltiorrhizae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is the 5.5-6.8 of 9 taste crude drug gross weights doubly (preferred amount of water is 6.6 times of 9 taste crude drug gross weights), each decoction 1.5 hours, merges twice medicinal liquid;
(5) by step (2) and the mixing of step (4) gained, leave standstill 12 hours, get the supernatant, be condensed into the thick paste (being preferably condensed into the thick paste that relative density is 1.35) that relative density is 1.34-1.36,60 DEG C of dryings 10 hours, take out, be ground into fine powder, cross No. five sieves;
(6) by step (1) and the mixing of step (5) gained, stir, 60 DEG C of dryings 20 hours, are ground into fine powder, cross No. five sieves, with the general ball of 65% ethanol, make the pill that particle diameter is 5mm, and drying, to obtain final product.
The preparation method of described capsule is:
(1) Herba equiseti ramosissimi is put into 55 DEG C of baking ovens, dry 12 hours, take out, be ground into fine powder, cross No. five sieves, soak 1.5-2.5 hour (preferably soaking 2 hours), amount of water is 3.2-4.6 times (preferred amount of water is 4.2 times of Herba equiseti ramosissimi fine powder weight) of Herba equiseti ramosissimi fine powder weight, be heated to 70 DEG C, and stirring makes into pasty state, for subsequent use;
(2) Folium Pleioblasti, Flos Rosae Rugosae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is the 4.3-6 of three taste crude drug gross weights doubly (preferred amount of water is 5 times of three taste crude drug gross weights), each decoction 15-25 minute (preferably each decoction 20 minutes), merges twice medicinal liquid;
(3) Radix Salviae Miltiorrhizae is dropped in pot, fry 8-12 minute (preferably frying 10 minutes with slow fire) with slow fire, take out, cool;
(4) step (3) gained and all the other the 9 taste crude drug except Folium Pleioblasti, Herba equiseti ramosissimi, Flos Rosae Rugosae, Radix Salviae Miltiorrhizae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is the 5.5-6.8 of 9 taste crude drug gross weights doubly (preferred amount of water is 6.6 times of 9 taste crude drug gross weights), each decoction 1.5 hours, merges twice medicinal liquid;
(5) by step (2) and the mixing of step (4) gained, leave standstill 12 hours, get the supernatant, be condensed into the thick paste (being preferably condensed into the thick paste that relative density is 1.35) that relative density is 1.34-1.36,60 DEG C of dryings 10 hours, take out, be ground into fine powder, cross No. five sieves;
(6) by step (1) and the mixing of step (5) gained, stir, 60 DEG C of dryings 20 hours, are ground into fine powder, cross No. five sieves, add mannitol, the weight of mannitol is 1/5 of step (1) and step (5) gained gross weight, and mix homogeneously, in incapsulating, medicated powder 0.35g is housed in every capsules, obtains final product.
The preparation method of described granule is:
(1) Herba equiseti ramosissimi is put into 55 DEG C of baking ovens, dry 12 hours, take out, be ground into fine powder, cross No. five sieves, soak 1.5-2.5 hour (preferably soaking 2 hours), amount of water is 3.2-4.6 times (preferred amount of water is 4.2 times of Herba equiseti ramosissimi fine powder weight) of Herba equiseti ramosissimi fine powder weight, be heated to 70 DEG C, and stirring makes into pasty state, for subsequent use;
(2) Folium Pleioblasti, Flos Rosae Rugosae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is the 4.3-6 of three taste crude drug gross weights doubly (preferred amount of water is 5 times of three taste crude drug gross weights), each decoction 15-25 minute (preferably each decoction 20 minutes), merges twice medicinal liquid;
(3) Radix Salviae Miltiorrhizae is dropped in pot, fry 8-12 minute (preferably frying 10 minutes with slow fire) with slow fire, take out, cool;
(4) step (3) gained and all the other the 9 taste crude drug except Folium Pleioblasti, Herba equiseti ramosissimi, Flos Rosae Rugosae, Radix Salviae Miltiorrhizae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is the 5.5-6.8 of 9 taste crude drug gross weights doubly (preferred amount of water is 6.6 times of 9 taste crude drug gross weights), each decoction 1.5 hours, merges twice medicinal liquid;
(5) by step (2) and the mixing of step (4) gained, leave standstill 12 hours, get the supernatant, be condensed into the thick paste (being preferably condensed into the thick paste that relative density is 1.35) that relative density is 1.34-1.36,60 DEG C of dryings 10 hours, take out, be ground into fine powder, cross No. five sieves;
(6) by step (1) and the mixing of step (5) gained, stir, 60 DEG C of dryings 20 hours, are ground into fine powder, cross No. five sieves, add 14% starch slurry, make soft material, with a sieve extrusion granulator, wet granular spreads out in enamel tray, to put in baking oven 50 DEG C of dryings 6 hours, to obtain final product.
The preparation method of described tablet is:
(1) Herba equiseti ramosissimi is put into 55 DEG C of baking ovens, dry 12 hours, take out, be ground into fine powder, cross No. five sieves, soak 1.5-2.5 hour (preferably soaking 2 hours), amount of water is 3.2-4.6 times (preferred amount of water is 4.2 times of Herba equiseti ramosissimi fine powder weight) of Herba equiseti ramosissimi fine powder weight, be heated to 70 DEG C, and stirring makes into pasty state, for subsequent use;
(2) Folium Pleioblasti, Flos Rosae Rugosae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is the 4.3-6 of three taste crude drug gross weights doubly (preferred amount of water is 5 times of three taste crude drug gross weights), each decoction 15-25 minute (preferably each decoction 20 minutes), merges twice medicinal liquid;
(3) Radix Salviae Miltiorrhizae is dropped in pot, fry 8-12 minute (preferably frying 10 minutes with slow fire) with slow fire, take out, cool;
(4) step (3) gained and all the other the 9 taste crude drug except Folium Pleioblasti, Herba equiseti ramosissimi, Flos Rosae Rugosae, Radix Salviae Miltiorrhizae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is the 5.5-6.8 of 9 taste crude drug gross weights doubly (preferred amount of water is 6.6 times of 9 taste crude drug gross weights), each decoction 1.5 hours, merges twice medicinal liquid;
(5) by step (2) and the mixing of step (4) gained, leave standstill 12 hours, get the supernatant, be condensed into the thick paste (being preferably condensed into the thick paste that relative density is 1.35) that relative density is 1.34-1.36,60 DEG C of dryings 10 hours, take out, be ground into fine powder, cross No. five sieves;
(6) by step (1) and the mixing of step (5) gained, stir, 60 DEG C of dryings 20 hours, be ground into fine powder, cross No. five sieves, add starch and dextrin, the weight of starch and dextrin is respectively 1/3 and 1/8 of step (1) and step (5) gained gross weight, mix homogeneously, is pressed into the tablet that diameter is 1cmm, obtains final product.
The uremic prescription scientific formula for the treatment of provided by the invention, the preparation method of various dosage form is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1, based on natural plants, be easy to draw materials, cheap, medical expense is lower, and to human non-toxic's side effect,
Do not rebound, improve body constitution by entirety conditioning, strengthen disease resistance ability;
2, can go directly after active Chinese drug component material enters human body nephropathy stove fast, and causes the various virulence factors such as nephritoxic factor
Combine closely, and carry out strong attack to it, it is broken, cracking is also thoroughly removed, and blocks kidney and continues deterioration, preserve the functions such as remnant kidney;
3, can blood circulation promoting, promote the abundant excretion of the metabolites such as toxin, systemic toxicity profiles symptom disappears thereupon;
4, there is effect of promoting the flow of QI-blood by warming the meridian, expelling wind and removing dampness, heat-clearing and toxic substances removing, strengthening spleen and nourishing blood, invigorating the liver and kidney, warming middle-JIAO for easing the stomach, warming middle-JIAO to stop diarrhea, blood circulation promoting and blood stasis dispelling, determined curative effect, Be very effective.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1treat uremic prescription, the primary raw material medicine getting following weight parts is prepared from (every part is 400g): Ramulus Cinnamomi 8 parts, Folium Pleioblasti 10 parts, Herba equiseti ramosissimi 7 parts, tomentose fevervine herb 6 parts, Flos Rosae Rugosae 4 parts, Radix Rauvolfiae 6 parts, Radix Salviae Miltiorrhizae 8 parts, Radix Stellariae Yunnanensis 10 parts, Cacumen Securinegae Suffruticosae 7 parts, 9 parts, Herba Cymbopogonis Citrari, Radix Achyranthis Bidentatae 6 parts, Flos Magnoliae Cocinis 5 parts, Caulis Caryophylli 3 parts, Herba hypoxis aureae 7 parts.
The preparation method of the uremic prescription granule of above-mentioned treatment is:
(1) Herba equiseti ramosissimi is put into 55 DEG C of baking ovens, dry 12 hours, take out, be ground into fine powder, cross No. five sieves, soak 1.5 hours, amount of water is 3.2 times of Herba equiseti ramosissimi fine powder weight, is heated to 70 DEG C, and stirring makes into pasty state, for subsequent use;
(2) Folium Pleioblasti, Flos Rosae Rugosae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is 4.3 times of three taste crude drug gross weights, and each decoction 15 minutes, merges twice medicinal liquid;
(3) Radix Salviae Miltiorrhizae is dropped in pot, fry 8 minutes with slow fire, take out, cool;
(4) step (3) gained and all the other the 9 taste crude drug except Folium Pleioblasti, Herba equiseti ramosissimi, Flos Rosae Rugosae, Radix Salviae Miltiorrhizae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is 5.5 times of 9 taste crude drug gross weights, and each decoction 1.5 hours, merges twice medicinal liquid;
(5) by step (2) and the mixing of step (4) gained, leave standstill 12 hours, get the supernatant, be condensed into the thick paste that relative density is 1.34,60 DEG C of dryings 10 hours, take out, be ground into fine powder, cross No. five sieves;
(6) by step (1) and the mixing of step (5) gained, stir, 60 DEG C of dryings 20 hours, are ground into fine powder, cross No. five sieves, add 14% starch slurry, make soft material, with a sieve extrusion granulator, wet granular spreads out in enamel tray, to put in baking oven 50 DEG C of dryings 6 hours, to obtain final product.
The instructions of taking that gained of the present invention treats uremic prescription granule is: oral, and three times on the one, each 10g, boiled water is taken after mixing it with water.
embodiment 2treat uremic prescription, the primary raw material medicine getting following weight parts is prepared from (every part is 400g): Ramulus Cinnamomi 13 parts, Folium Pleioblasti 14 parts, Herba equiseti ramosissimi 15 parts, tomentose fevervine herb 12 parts, Flos Rosae Rugosae 9 parts, Radix Rauvolfiae 10 parts, Radix Salviae Miltiorrhizae 12 parts, Radix Stellariae Yunnanensis 15 parts, Cacumen Securinegae Suffruticosae 13 parts, 12 parts, Herba Cymbopogonis Citrari, Radix Achyranthis Bidentatae 11 parts, Flos Magnoliae Cocinis 10 parts, Caulis Caryophylli 8 parts, Herba hypoxis aureae 14 parts.
The preparation method of the uremic prescription pill of above-mentioned treatment is:
(1) Herba equiseti ramosissimi is put into 55 DEG C of baking ovens, dry 12 hours, take out, be ground into fine powder, cross No. five sieves, soak 2 hours, amount of water is 4.2 times of Herba equiseti ramosissimi fine powder weight, is heated to 70 DEG C, and stirring makes into pasty state, for subsequent use;
(2) Folium Pleioblasti, Flos Rosae Rugosae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is 5 times of three taste crude drug gross weights, and each decoction 20 minutes, merges twice medicinal liquid;
(3) Radix Salviae Miltiorrhizae is dropped in pot, fry 10 minutes with slow fire, take out, cool;
(4) step (3) gained and all the other the 9 taste crude drug except Folium Pleioblasti, Herba equiseti ramosissimi, Flos Rosae Rugosae, Radix Salviae Miltiorrhizae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is 6.6 times of 9 taste crude drug gross weights, and each decoction 1.5 hours, merges twice medicinal liquid;
(5) by step (2) and the mixing of step (4) gained, leave standstill 12 hours, get the supernatant, be condensed into the thick paste that relative density is 1.35,60 DEG C of dryings 10 hours, take out, be ground into fine powder, cross No. five sieves;
(6) by step (1) and the mixing of step (5) gained, stir, 60 DEG C of dryings 20 hours, are ground into fine powder, cross No. five sieves, with the general ball of 65% ethanol, make the pill that particle diameter is 5mm, and drying, to obtain final product.
model case one:xu XX, female, 51 years old.Before 4 years, there is edema without obvious inducement in patient, checks urine protein (+++), occult blood (++) at local hospital, and after treatment, in urine, occult blood disappears, but albumen sustainable existence in urine.Before 1 month, there is malaise in patient, poor appetite symptom.Examination in hospital nearby, examines as uremia.Hospital's suggestion dialysis, because of dialysis somewhat expensive, can't afford, and refuse.Carry out here diagnosis and treatment after being introduced.Anemia looks, cardiopulmonary and abdominal part no abnormality seen, two lower limb pitting edema, have a blood test Lactoferrin 50g/L, serum creatinine 732 μm of ol/L, blood urea nitrogen 35mmol/L, CO2 combining power, CO2 CP 17mmol/L.Examine as uremia.Take the present embodiment gained and treat uremic prescription pill, three times on the one, each 2 balls, warm water takes.Take two weeks, symptom takes a turn for the better.Take 2 months, all transference cures, health indices recovers normal.Follow up a case by regular visits to without bounce-back.
embodiment 3treat uremic prescription, the primary raw material medicine getting following weight parts is prepared from (every part is 400g): Ramulus Cinnamomi 9 parts, Folium Pleioblasti 11 parts, Herba equiseti ramosissimi 9 parts, tomentose fevervine herb 8 parts, Flos Rosae Rugosae 5 parts, Radix Rauvolfiae 7 parts, Radix Salviae Miltiorrhizae 9 parts, Radix Stellariae Yunnanensis 12 parts, Cacumen Securinegae Suffruticosae 9 parts, 10 parts, Herba Cymbopogonis Citrari, Radix Achyranthis Bidentatae 8 parts, Flos Magnoliae Cocinis 7 parts, Caulis Caryophylli 4 parts, Herba hypoxis aureae 8 parts.
The preparation method of the uremic prescription capsule of above-mentioned treatment is:
(1) Herba equiseti ramosissimi is put into 55 DEG C of baking ovens, dry 12 hours, take out, be ground into fine powder, cross No. five sieves, soak 2 hours, amount of water is 4.2 times of Herba equiseti ramosissimi fine powder weight, is heated to 70 DEG C, and stirring makes into pasty state, for subsequent use;
(2) Folium Pleioblasti, Flos Rosae Rugosae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is 5 times of three taste crude drug gross weights, and each decoction 20 minutes, merges twice medicinal liquid;
(3) Radix Salviae Miltiorrhizae is dropped in pot, fry 10 minutes with slow fire, take out, cool;
(4) step (3) gained and all the other the 9 taste crude drug except Folium Pleioblasti, Herba equiseti ramosissimi, Flos Rosae Rugosae, Radix Salviae Miltiorrhizae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is 6.6 times of 9 taste crude drug gross weights, and each decoction 1.5 hours, merges twice medicinal liquid;
(5) by step (2) and the mixing of step (4) gained, leave standstill 12 hours, get the supernatant, be condensed into the thick paste that relative density is 1.35,60 DEG C of dryings 10 hours, take out, be ground into fine powder, cross No. five sieves;
(6) by step (1) and the mixing of step (5) gained, stir, 60 DEG C of dryings 20 hours, are ground into fine powder, cross No. five sieves, add mannitol, the weight of mannitol is 1/5 of step (1) and step (5) gained gross weight, and mix homogeneously, in incapsulating, medicated powder 0.35g is housed in every capsules, obtains final product.
model case two:yellow XX, man, 30 years old.Before more than 2 years, patient occurs dizzy without obvious inducement, feel sick, malaise, the symptoms such as chest distress, examine as uremia to examination in hospital.Then hemodialysis is accepted.Before 1 month, there is whole body pruritis in patient, used multi-medicament all invalid.Through making some inquiries about, my institute's diagnosis and treatment of coming.Entire patient's pruritus, dizzy, feel sick, malaise, chest distress.Have a blood test creatinine 1130 μm of ol/L, blood urea nitrogen 50mmol/L, hemoglobin 45g/L.Be diagnosed as uremia.Take the present embodiment gained and treat uremic prescription capsule, three times on the one, each 2, warm water takes.Take 1 month, symptom is clearly better.Take 2 months, symptom all disappears, and health indices is all down to normally.Follow up a case by regular visits to without bounce-back.
embodiment 4treat uremic prescription, the primary raw material medicine getting following weight parts is prepared from (every part is 400g): Ramulus Cinnamomi 12 parts, Folium Pleioblasti 13 parts, Herba equiseti ramosissimi 12 parts, tomentose fevervine herb 11 parts, Flos Rosae Rugosae 8 parts, Radix Rauvolfiae 9 parts, Radix Salviae Miltiorrhizae 11 parts, Radix Stellariae Yunnanensis 14 parts, Cacumen Securinegae Suffruticosae 12 parts, 11 parts, Herba Cymbopogonis Citrari, Radix Achyranthis Bidentatae 10 parts, Flos Magnoliae Cocinis 9 parts, Caulis Caryophylli 7 parts, Herba hypoxis aureae 11 parts.
The preparation method of the uremic prescription tablet of above-mentioned treatment is:
(1) Herba equiseti ramosissimi is put into 55 DEG C of baking ovens, dry 12 hours, take out, be ground into fine powder, cross No. five sieves, soak 2 hours, amount of water is 4.2 times of Herba equiseti ramosissimi fine powder weight, is heated to 70 DEG C, and stirring makes into pasty state, for subsequent use;
(2) Folium Pleioblasti, Flos Rosae Rugosae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is 5 times of three taste crude drug gross weights, and each decoction 20 minutes, merges twice medicinal liquid;
(3) Radix Salviae Miltiorrhizae is dropped in pot, fry 10 minutes with slow fire, take out, cool;
(4) step (3) gained and all the other the 9 taste crude drug except Folium Pleioblasti, Herba equiseti ramosissimi, Flos Rosae Rugosae, Radix Salviae Miltiorrhizae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is 6.6 times of 9 taste crude drug gross weights, and each decoction 1.5 hours, merges twice medicinal liquid;
(5) by step (2) and the mixing of step (4) gained, leave standstill 12 hours, get the supernatant, be condensed into the thick paste that relative density is 1.35,60 DEG C of dryings 10 hours, take out, be ground into fine powder, cross No. five sieves;
(6) by step (1) and the mixing of step (5) gained, stir, 60 DEG C of dryings 20 hours, be ground into fine powder, cross No. five sieves, add starch and dextrin, the weight of starch and dextrin is respectively 1/3 and 1/8 of step (1) and step (5) gained gross weight, mix homogeneously, is pressed into the tablet that diameter is 1cmm, obtains final product.
model case three:xX recklessly, man, 63 years old.Before more than 1 year, the symptoms such as palpitation and short breath appears in patient, malaise, in local hospital inspection, examine as uremia.After this, accept hemodialysis always.Stop dialysis afterwards because can't afford medical expense, after stopping dialysis, the state of an illness rebounds.Its household goes to a doctor through making some inquiries about then coming here.Examine and see patient's palpitation and short breath, malaise, edema of pair of lower extremities.Have a blood test creatinine 1230 μm of ol/L, blood urea nitrogen 46.57mmol/L.Be diagnosed as uremia.Take the present embodiment gained and treat uremic prescription tablet, three times on the one, each 2, warm water takes.After taking 20 days, symptom alleviates, and serum creatinine declines.Take after two months, all diseases disappear, and all recover normal to examination in hospital indices.Follow up a case by regular visits to without bounce-back.
embodiment 5treat uremic prescription, the primary raw material medicine getting following weight parts is prepared from (every part is 400g): Ramulus Cinnamomi 10 parts, Folium Pleioblasti 12 parts, Herba equiseti ramosissimi 11 parts, tomentose fevervine herb 10 parts, Flos Rosae Rugosae 7 parts, Radix Rauvolfiae 8 parts, Radix Salviae Miltiorrhizae 10 parts, Radix Stellariae Yunnanensis 13 parts, Cacumen Securinegae Suffruticosae 11 parts, 10.5 parts, Herba Cymbopogonis Citrari, Radix Achyranthis Bidentatae 9 parts, Flos Magnoliae Cocinis 8 parts, Caulis Caryophylli 6 parts, Herba hypoxis aureae 9 parts.
The preparation method of the uremic prescription granule of above-mentioned treatment is:
(1) Herba equiseti ramosissimi is put into 55 DEG C of baking ovens, dry 12 hours, take out, be ground into fine powder, cross No. five sieves, soak 2 hours, amount of water is 4.2 times of Herba equiseti ramosissimi fine powder weight, is heated to 70 DEG C, and stirring makes into pasty state, for subsequent use;
(2) Folium Pleioblasti, Flos Rosae Rugosae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is 5 times of three taste crude drug gross weights, and each decoction 20 minutes, merges twice medicinal liquid;
(3) Radix Salviae Miltiorrhizae is dropped in pot, fry 10 minutes with slow fire, take out, cool;
(4) step (3) gained and all the other the 9 taste crude drug except Folium Pleioblasti, Herba equiseti ramosissimi, Flos Rosae Rugosae, Radix Salviae Miltiorrhizae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is 6.6 times of 9 taste crude drug gross weights, and each decoction 1.5 hours, merges twice medicinal liquid;
(5) by step (2) and the mixing of step (4) gained, leave standstill 12 hours, get the supernatant, be condensed into the thick paste that relative density is 1.35,60 DEG C of dryings 10 hours, take out, be ground into fine powder, cross No. five sieves;
(6) by step (1) and the mixing of step (5) gained, stir, 60 DEG C of dryings 20 hours, are ground into fine powder, cross No. five sieves, add 14% starch slurry, make soft material, with a sieve extrusion granulator, wet granular spreads out in enamel tray, to put in baking oven 50 DEG C of dryings 6 hours, to obtain final product.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Ramulus Cinnamomi: base is former: be the twig of canella Cortex Cinnamomi.Ramulus Cinnamomi is containing volatile oil 0.69%, and in oil, main component is cinnamic aldehyde 64.75%, also has benzyl benzoate, cinnamyl acetate, β-cadinene, Chang Pu alkene, coumarin etc.The property of medicine: acrid, sweet, warm.Return bladder, the heart, lung meridian.Function cures mainly: expelling cold and relieving exterior syndrome, promoting the flow of QI-blood by warming the meridian.For activating YANG and prormoting functioning of QI exterior syndrome due to wind-cold, arthralgia due to cold-dampnes, extreme cold of the limbs, amenorrhea dysmenorrhea ， mass in the abdomen lumps, the thoracic obstruction, cardiopalmus, phlegm retention, dysuria.
Folium Pleioblasti: base is former: be the tender leaf of grass bitter bamboo.The property of medicine: bitter; Cold.GUIXIN, Liver Channel.Function cures mainly: clear away heart-fire, diuresis improving eyesight, removing toxic substances.Main calentura excessive thirst, insomnia, oliguria with reddish urine, aphtha, ophthalmalgia, aphonia, burn and scald.
Herba equiseti ramosissimi: base is former: be the herb of Equisetaceae plant Herba Clinopodii Polycephali.The property of medicine: sweet; Bitter; Flat; Nontoxic; Be slightly cold.GUIXIN, liver, stomach, urinary bladder channel.Function cures mainly: liver heat removing and eyesight improving; Hemostasis; Inducing diuresis for treating stranguria syndrome.Main anemopyretic cold; Cough; Conjunctival congestion and swelling pain; Nebula; Epistaxis; Hematuria; Discharging fresh blood stool; Stranguria; Jaundice; Leukorrhagia; Fracture.
Tomentose fevervine herb: base is former: be root or the herb of Rubiaceae Paederia vegetable hair fevervine.The property of medicine: sour, sweet, flat.Function cures mainly: expelling wind and removing dampness, heat-clearing and toxic substances removing, promoting flow of QI and blood.Cure mainly polarization wind syndrome of head, jaundice due to damp-heat, dysentery, food stagnation is glutted, treating swelling and pain by traumatic injury.
Flos Rosae Rugosae: base is former: be the flower of rosaceous plant Flos Rosae Rugosae and polyphyll Flos Rosae Rugosae.The property of medicine: sweet; Micro-hardship; Temperature; Nontoxic.Return liver, spleen channel.Function cures mainly: resolving depression of regulating the flow of vital energy; Regulating menstruation by adjusting the flow of blood.Chest and diaphragm caused by main depression of liver-QI is full vexed, and gastral cavity side of body distending pain, breast is done swollen, menoxenia, and dysentery is had loose bowels, leukorrhagia, traumatic injury, carbuncle.
Radix Rauvolfiae: base is former: be the root of apocynaceae plant Radix Rauvolfiae.The property of medicine: bitter; Micro-pungent; Cool in nature.Function cures mainly: heat clearing away; Blood pressure lowering; Allay excitement.Main cold, fever; Headache body pain; Laryngopharynx swelling and pain; Hypertension; Dizzy; Insomnia.
Radix Salviae Miltiorrhizae: base is former: be the dry root and rhizome of labiate Radix Salviae Miltiorrhizae.The property of medicine: bitter, is slightly cold.GUIXIN, Liver Channel.Function cures mainly: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, and clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea ， lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Radix Stellariae Yunnanensis: base is former: be the root of Caryophyllaceae Stellaria plant Yunnan Herba stellariae mediae.Composition: containing peptide class: Herba stellariae mediae cyclic peptide A, B, C, D, E, F, G, false Herba stellariae mediae cyclic peptide A-H, Yunnan Herba stellariae mediae cyclic peptide A, B, D, C, E, F.The property of medicine: sweet, flat.Function cures mainly: strengthening spleen and nourishing blood, invigorating the liver and kidney, detumescence.Cure mainly anemia, dizzy nervous, tinnitus hectic fever, the soreness of waist, seminal emission, menoxenia, leukorrhagia, fracture, mastitis.
Cacumen Securinegae Suffruticosae: base is former: be the herb of Euphorbiaceae phyllanthus emblica platymiscium Cacumen Securinegae Suffruticosae.The property of medicine: micro-hardship, sweet, cool.Function cures mainly: clearing away heat and promoting diuresis, improving eyesight, removing food stagnancy.For oedema due to nephritis, urinary system infection, calculus, enteritis, dysentery, young waiter in a wineshop or an inn's infantile malnutrition, eye keratitis, icterohepatitis, external is controlled Trimeresurus stejnegeri and is bitten.
Herba Cymbopogonis Citrari: base is former: be the flower of grass Herba Cymbopogonis Citrari.The property of medicine: sweet; Micro-hardship; Temperature.Function cures mainly: warming middle-JIAO for easing the stomach.Main trusted subordinate's cold type of pain; Nausea and vomiting.
Radix Achyranthis Bidentatae: base is former: be the root of amaranthaceous plant Radix Achyranthis Bidentatae.The property of medicine: bitter, acid, property is put down.Return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, and it is descending to draw enemy state's (fire), inducing diuresis for treating stranguria syndrome.Main soreness of waist and knee joint, flaccidity and weakness of the lower limbs, amenorrhea due to stagnation of blood, dysmenorrhea, puerperal, abdominal pain due to blood stasis, levied abdominal mass, retention of placenta, pyretic stranguria, stranguria with blood, traumatic injury, carbuncle malignant boil, laryngopharynx swelling and pain.
Flos Magnoliae Cocinis: base is former: be the root of feverfew Herba Inulae cappae.The property of medicine: acrid in the mouth; Sweet; Warm in nature.Function cures mainly: expelling wind and cold; Relieving cough and relieving asthma; Promoting the circulation of QI to relieve pain.Main anemofrigid cold; Cough; Asthma; Headache; Toothache; Stomachache; Hernia; Rheumatic arthralgia; Traumatic injury; Menoxenia; Leucorrhea; Oedema due to nephritis.
Caulis Caryophylli: base is former: be the branch of plant clove of myrtaceae.The property of medicine: acrid in the mouth; Property is put down.Return spleen, stomach warp.Function cures mainly: cold expelling of regulating the flow of vital energy; Warming middle-JIAO to stop diarrhea.Main distension and fullness in the abdomen; Feel sick; Have loose bowels empty sliding; Indigestion.
Herba hypoxis aureae: base is former: be the Herb of bloodwort Herba hypoxis aureae.The property of medicine: sweet, micro-pungent, warm.Function cures mainly: warming the kidney to invigorate YANG; Regulating QI to relieve pain.Main lumbago due to renal deficiency; Sexual impotence; Insomnia; Colic of cold type is suffered from abdominal pain.
test example 1gained of the present invention treats the clinical practice of uremic prescription (embodiment 5): in August ,-2012 in March, 2010, screen 220 routine uremic patients in 3 hospitals, wherein male 96 example, women 124 example, oldest 64 years old, minimum 25 years old of age.Be divided into two groups at random, experimental group and matched group (often organizing 110 examples).Between two groups of patients, physical data aspect compares sex, age etc., and no significant difference (P > 0.05), has comparability.Experimental group takes gained products obtained therefrom of the present invention, instructions of taking: oral, and three times on the one, each 10g, boiled water is taken after mixing it with water.Matched group uses the Drug therapys such as NIAODUQING KELI, Hai Kun Sheng Xi Capsule, α keto acid compound.Within 20 days, be 1 course for the treatment of, after treating 3 courses for the treatment of, carry out therapeutic evaluation.
Curative effect situation criterion: cure: clinical symptoms all disappears, and lab testing is normal; Effective: clinical symptoms major part disappears, and lab testing obviously improves; Take a turn for the better: clinical symptoms takes a turn for the better or partial disappearance, lab testing takes a turn for the better; Invalid: clinical symptoms and lab testing are all without improvement.Always effectively comprise healing, effective and improvement, result is as shown in table 1.
Table 1: gained of the present invention treats uremic prescription compliance test result
As can be seen from Table 1, the experimental group cure rate using gained of the present invention to treat uremic prescription is 65.45%, and total effective rate reaches 96.36%.And the cure rate of matched group is 10.91%, total effective rate is 67.27%.The cure rate of experimental group improves 54.54% than the cure rate of matched group, and total effective rate adds 29.09%.Test shows, the successful of experimental group is better than matched group.
The present invention for instructing, carries out scientific composition with traditional Chinese medical science traditional theory, selects the Chinese herbal medicine such as Ramulus Cinnamomi, Folium Pleioblasti, Herba equiseti ramosissimi and tomentose fevervine herb to be primary raw material, makes the uremic prescription for the treatment of.Ramulus Cinnamomi expelling cold and relieving exterior syndrome in side, promoting the flow of QI-blood by warming the meridian.Folium Pleioblasti clears away heart-fire, diuresis improving eyesight, removing toxic substances.Herba equiseti ramosissimi liver heat removing and eyesight improving; Hemostasis; Inducing diuresis for treating stranguria syndrome.Tomentose fevervine herb expelling wind and removing dampness, heat-clearing and toxic substances removing, promoting flow of QI and blood.Flos Rosae Rugosae is regulated the flow of vital energy resolving depression; Regulating menstruation by adjusting the flow of blood.Radix Rauvolfiae heat clearing away; Blood pressure lowering; Allay excitement.Radix Salviae Miltiorrhizae stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.Radix Stellariae Yunnanensis strengthening spleen and nourishing blood, invigorating the liver and kidney, detumescence.Cacumen Securinegae Suffruticosae clearing away heat and promoting diuresis, improving eyesight, removing food stagnancy.Herba Cymbopogonis Citrari warming middle-JIAO for easing the stomach.Radix Achyranthis Bidentatae invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, it is descending to draw enemy state's (fire), inducing diuresis for treating stranguria syndrome.Flos Magnoliae Cocinis expelling wind and cold; Relieving cough and relieving asthma; Promoting the circulation of QI to relieve pain.Caulis Caryophylli is regulated the flow of vital energy cold expelling; Warming middle-JIAO to stop diarrhea.Herba hypoxis aureae warming the kidney to invigorate YANG; Regulating QI to relieve pain.Many medicines share, mutual coordination, play the effect of promoting the flow of QI-blood by warming the meridian, expelling wind and removing dampness, heat-clearing and toxic substances removing, strengthening spleen and nourishing blood, invigorating the liver and kidney, warming middle-JIAO for easing the stomach, warming middle-JIAO to stop diarrhea, blood circulation promoting and blood stasis dispelling altogether, improve body constitution by entirety conditioning, strengthen disease resistance ability, preserve the functions such as remnant kidney, can blood circulation promoting, promote the abundant excretion of the metabolites such as toxin, systemic toxicity profiles symptom disappears thereupon, determined curative effect, Be very effective.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. treat uremic prescription, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Ramulus Cinnamomi 8-13, Folium Pleioblasti 10-14, Herba equiseti ramosissimi 7-15, tomentose fevervine herb 6-12, Flos Rosae Rugosae 4-9, Radix Rauvolfiae 6-10, Radix Salviae Miltiorrhizae 8-12, Radix Stellariae Yunnanensis 10-15, Cacumen Securinegae Suffruticosae 7-13, Herba Cymbopogonis Citrari 9-12, Radix Achyranthis Bidentatae 6-11, Flos Magnoliae Cocinis 5-10, Caulis Caryophylli 3-8, Herba hypoxis aureae 7-14.
2. the uremic prescription for the treatment of as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Ramulus Cinnamomi 9-12, Folium Pleioblasti 11-13, Herba equiseti ramosissimi 9-12, tomentose fevervine herb 8-11, Flos Rosae Rugosae 5-8, Radix Rauvolfiae 7-9, Radix Salviae Miltiorrhizae 9-11, Radix Stellariae Yunnanensis 12-14, Cacumen Securinegae Suffruticosae 9-12, Herba Cymbopogonis Citrari 10-11, Radix Achyranthis Bidentatae 8-10, Flos Magnoliae Cocinis 7-9, Caulis Caryophylli 4-7, Herba hypoxis aureae 8-11.
3. the uremic prescription for the treatment of as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Ramulus Cinnamomi 10, Folium Pleioblasti 12, Herba equiseti ramosissimi 11, tomentose fevervine herb 10, Flos Rosae Rugosae 7, Radix Rauvolfiae 8, Radix Salviae Miltiorrhizae 10, Radix Stellariae Yunnanensis 13, Cacumen Securinegae Suffruticosae 11, Herba Cymbopogonis Citrari 10.5, Radix Achyranthis Bidentatae 9, Flos Magnoliae Cocinis 8, Caulis Caryophylli 6, Herba hypoxis aureae 9.
4. the uremic prescription for the treatment of as described in as arbitrary in claims 1 to 3, it is characterized in that, uremic for this treatment prescription is made pharmaceutically acceptable pill, and the preparation method of described pill is:
(1) Herba equiseti ramosissimi is put into 55 DEG C of baking ovens, dry 12 hours, take out, be ground into fine powder, cross No. five sieves, soak 1.5-2.5 hour (preferably soaking 2 hours), amount of water is 3.2-4.6 times (preferred amount of water is 4.2 times of Herba equiseti ramosissimi fine powder weight) of Herba equiseti ramosissimi fine powder weight, be heated to 70 DEG C, and stirring makes into pasty state, for subsequent use;
(2) Folium Pleioblasti, Flos Rosae Rugosae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is the 4.3-6 of three taste crude drug gross weights doubly (preferred amount of water is 5 times of three taste crude drug gross weights), each decoction 15-25 minute (preferably each decoction 20 minutes), merges twice medicinal liquid;
(3) Radix Salviae Miltiorrhizae is dropped in pot, fry 8-12 minute (preferably frying 10 minutes with slow fire) with slow fire, take out, cool;
(4) step (3) gained and all the other the 9 taste crude drug except Folium Pleioblasti, Herba equiseti ramosissimi, Flos Rosae Rugosae, Radix Salviae Miltiorrhizae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is the 5.5-6.8 of 9 taste crude drug gross weights doubly (preferred amount of water is 6.6 times of 9 taste crude drug gross weights), each decoction 1.5 hours, merges twice medicinal liquid;
(5) by step (2) and the mixing of step (4) gained, leave standstill 12 hours, get the supernatant, be condensed into the thick paste (being preferably condensed into the thick paste that relative density is 1.35) that relative density is 1.34-1.36,60 DEG C of dryings 10 hours, take out, be ground into fine powder, cross No. five sieves;
(6) by step (1) and the mixing of step (5) gained, stir, 60 DEG C of dryings 20 hours, are ground into fine powder, cross No. five sieves, with the general ball of 65% ethanol, make the pill that particle diameter is 5mm, and drying, to obtain final product.
5. the uremic prescription for the treatment of as described in as arbitrary in claims 1 to 3, it is characterized in that, uremic for this treatment prescription is made pharmaceutically acceptable capsule, and the preparation method of described capsule is:
(1) Herba equiseti ramosissimi is put into 55 DEG C of baking ovens, dry 12 hours, take out, be ground into fine powder, cross No. five sieves, soak 1.5-2.5 hour (preferably soaking 2 hours), amount of water is 3.2-4.6 times (preferred amount of water is 4.2 times of Herba equiseti ramosissimi fine powder weight) of Herba equiseti ramosissimi fine powder weight, be heated to 70 DEG C, and stirring makes into pasty state, for subsequent use;
(2) Folium Pleioblasti, Flos Rosae Rugosae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is the 4.3-6 of three taste crude drug gross weights doubly (preferred amount of water is 5 times of three taste crude drug gross weights), each decoction 15-25 minute (preferably each decoction 20 minutes), merges twice medicinal liquid;
(3) Radix Salviae Miltiorrhizae is dropped in pot, fry 8-12 minute (preferably frying 10 minutes with slow fire) with slow fire, take out, cool;
(4) step (3) gained and all the other the 9 taste crude drug except Folium Pleioblasti, Herba equiseti ramosissimi, Flos Rosae Rugosae, Radix Salviae Miltiorrhizae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is the 5.5-6.8 of 9 taste crude drug gross weights doubly (preferred amount of water is 6.6 times of 9 taste crude drug gross weights), each decoction 1.5 hours, merges twice medicinal liquid;
(5) by step (2) and the mixing of step (4) gained, leave standstill 12 hours, get the supernatant, be condensed into the thick paste (being preferably condensed into the thick paste that relative density is 1.35) that relative density is 1.34-1.36,60 DEG C of dryings 10 hours, take out, be ground into fine powder, cross No. five sieves;
(6) by step (1) and the mixing of step (5) gained, stir, 60 DEG C of dryings 20 hours, are ground into fine powder, cross No. five sieves, add mannitol, the weight of mannitol is 1/5 of step (1) and step (5) gained gross weight, and mix homogeneously, in incapsulating, medicated powder 0.35g is housed in every capsules, obtains final product.
6. the uremic prescription for the treatment of as described in as arbitrary in claims 1 to 3, it is characterized in that, uremic for this treatment prescription is made pharmaceutically acceptable granule, and the preparation method of described granule is:
(1) Herba equiseti ramosissimi is put into 55 DEG C of baking ovens, dry 12 hours, take out, be ground into fine powder, cross No. five sieves, soak 1.5-2.5 hour, amount of water is 3.2-4.6 times of Herba equiseti ramosissimi fine powder weight, is heated to 70 DEG C, and stirring makes into pasty state, for subsequent use;
(2) Folium Pleioblasti, Flos Rosae Rugosae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is the 4.3-6 of three taste crude drug gross weights doubly (preferred amount of water is 5 times of three taste crude drug gross weights), each decoction 15-25 minute (preferably each decoction 20 minutes), merges twice medicinal liquid;
(3) Radix Salviae Miltiorrhizae is dropped in pot, fry 8-12 minute with slow fire, take out, cool;
(4) step (3) gained and all the other the 9 taste crude drug except Folium Pleioblasti, Herba equiseti ramosissimi, Flos Rosae Rugosae, Radix Salviae Miltiorrhizae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is the 5.5-6.8 of 9 taste crude drug gross weights doubly (preferred amount of water is 6.6 times of 9 taste crude drug gross weights), each decoction 1.5 hours, merges twice medicinal liquid;
(5) by step (2) and the mixing of step (4) gained, leave standstill 12 hours, get the supernatant, be condensed into the thick paste (being preferably condensed into the thick paste that relative density is 1.35) that relative density is 1.34-1.36,60 DEG C of dryings 10 hours, take out, be ground into fine powder, cross No. five sieves;
(6) by step (1) and the mixing of step (5) gained, stir, 60 DEG C of dryings 20 hours, are ground into fine powder, cross No. five sieves, add 14% starch slurry, make soft material, with a sieve extrusion granulator, wet granular spreads out in enamel tray, to put in baking oven 50 DEG C of dryings 6 hours, to obtain final product.
7. the uremic prescription for the treatment of as described in as arbitrary in claims 1 to 3, it is characterized in that, uremic for this treatment prescription is made pharmaceutically acceptable tablet, and the preparation method of described tablet is:
(1) Herba equiseti ramosissimi is put into 55 DEG C of baking ovens, dry 12 hours, take out, be ground into fine powder, cross No. five sieves, soak 1.5-2.5 hour (preferably soaking 2 hours), amount of water is 3.2-4.6 times (preferred amount of water is 4.2 times of Herba equiseti ramosissimi fine powder weight) of Herba equiseti ramosissimi fine powder weight, be heated to 70 DEG C, and stirring makes into pasty state, for subsequent use;
(2) Folium Pleioblasti, Flos Rosae Rugosae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is the 4.3-6 of three taste crude drug gross weights doubly (preferred amount of water is 5 times of three taste crude drug gross weights), each decoction 15-25 minute (preferably each decoction 20 minutes), merges twice medicinal liquid;
(3) Radix Salviae Miltiorrhizae is dropped in pot, fry 8-12 minute (preferably frying 10 minutes with slow fire) with slow fire, take out, cool;
(4) step (3) gained and all the other the 9 taste crude drug except Folium Pleioblasti, Herba equiseti ramosissimi, Flos Rosae Rugosae, Radix Salviae Miltiorrhizae and Herba Cymbopogonis Citrari are decocted with water twice, amount of water is the 5.5-6.8 of 9 taste crude drug gross weights doubly (preferred amount of water is 6.6 times of 9 taste crude drug gross weights), each decoction 1.5 hours, merges twice medicinal liquid;
(5) by step (2) and the mixing of step (4) gained, leave standstill 12 hours, get the supernatant, be condensed into the thick paste (being preferably condensed into the thick paste that relative density is 1.35) that relative density is 1.34-1.36,60 DEG C of dryings 10 hours, take out, be ground into fine powder, cross No. five sieves;
(6) by step (1) and the mixing of step (5) gained, stir, 60 DEG C of dryings 20 hours, be ground into fine powder, cross No. five sieves, add starch and dextrin, the weight of starch and dextrin is respectively 1/3 and 1/8 of step (1) and step (5) gained gross weight, mix homogeneously, is pressed into the tablet that diameter is 1cmm, obtains final product.
8. the preparation method of the uremic prescription granule for the treatment of as claimed in claim 6, it is characterized in that, step soaks 2 hours in (1).
9. the preparation method of the uremic prescription granule for the treatment of as claimed in claim 6, is characterized in that, in step (1), amount of water is 4.2 times of Herba equiseti ramosissimi fine powder weight.
10. the preparation method of the uremic prescription granule for the treatment of as claimed in claim 6, is characterized in that, fry 10 minutes in step (3) with slow fire.
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| CN102370738A (en) * | 2010-08-19 | 2012-03-14 | 上海中医药大学附属曙光医院 | Chinese medicinal compound preparation for preventing and controlling chronic kidney disease and renal fibrosis, and preparation method thereof |
| CN104324253A (en) * | 2014-09-29 | 2015-02-04 | 赵霞 | Traditional Chinese medicine preparation for treating uremia and preparation method thereof |
| CN104547081A (en) * | 2014-12-22 | 2015-04-29 | 李祖望 | Medicine for treating chronic renal insufficiency and chronic renal failure diseases |
| CN104623183A (en) * | 2013-11-10 | 2015-05-20 | 青岛食之礼中草药研究所 | Traditional Chinese medicine decoction for treating chronic kidney failure |
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| CN102370738A (en) * | 2010-08-19 | 2012-03-14 | 上海中医药大学附属曙光医院 | Chinese medicinal compound preparation for preventing and controlling chronic kidney disease and renal fibrosis, and preparation method thereof |
| CN104623183A (en) * | 2013-11-10 | 2015-05-20 | 青岛食之礼中草药研究所 | Traditional Chinese medicine decoction for treating chronic kidney failure |
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