CN105192699A - Fish oil soft capsules and preparation method thereof - Google Patents
Fish oil soft capsules and preparation method thereof Download PDFInfo
- Publication number
- CN105192699A CN105192699A CN201510635138.3A CN201510635138A CN105192699A CN 105192699 A CN105192699 A CN 105192699A CN 201510635138 A CN201510635138 A CN 201510635138A CN 105192699 A CN105192699 A CN 105192699A
- Authority
- CN
- China
- Prior art keywords
- parts
- fish oil
- soft capsule
- glue
- honeysuckle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000021323 fish oil Nutrition 0.000 title claims abstract description 63
- 239000007901 soft capsule Substances 0.000 title claims abstract description 47
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- 229920000159 gelatin Polymers 0.000 claims abstract description 25
- 235000019322 gelatine Nutrition 0.000 claims abstract description 25
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 claims abstract description 23
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 23
- 241000208340 Araliaceae Species 0.000 claims abstract description 23
- 235000003097 Artemisia absinthium Nutrition 0.000 claims abstract description 23
- 240000001851 Artemisia dracunculus Species 0.000 claims abstract description 23
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 claims abstract description 23
- 235000003261 Artemisia vulgaris Nutrition 0.000 claims abstract description 23
- 108010010803 Gelatin Proteins 0.000 claims abstract description 23
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 23
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 23
- 239000001138 artemisia absinthium Substances 0.000 claims abstract description 23
- 239000008273 gelatin Substances 0.000 claims abstract description 23
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 23
- 235000008434 ginseng Nutrition 0.000 claims abstract description 23
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims abstract description 23
- 235000011187 glycerol Nutrition 0.000 claims abstract description 21
- 239000003292 glue Substances 0.000 claims description 50
- 239000000047 product Substances 0.000 claims description 24
- 241000233866 Fungi Species 0.000 claims description 22
- 241000222336 Ganoderma Species 0.000 claims description 22
- 240000001307 Myosotis scorpioides Species 0.000 claims description 22
- 240000007164 Salvia officinalis Species 0.000 claims description 22
- 235000005412 red sage Nutrition 0.000 claims description 22
- 238000012856 packing Methods 0.000 claims description 21
- 239000002994 raw material Substances 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 238000001035 drying Methods 0.000 claims description 14
- 238000010438 heat treatment Methods 0.000 claims description 14
- 238000007689 inspection Methods 0.000 claims description 14
- 239000005022 packaging material Substances 0.000 claims description 14
- 238000007789 sealing Methods 0.000 claims description 14
- 239000011265 semifinished product Substances 0.000 claims description 14
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 235000019198 oils Nutrition 0.000 claims description 9
- 230000003749 cleanliness Effects 0.000 claims description 7
- 239000000084 colloidal system Substances 0.000 claims description 7
- 239000004744 fabric Substances 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 238000009413 insulation Methods 0.000 claims description 7
- 238000011068 loading method Methods 0.000 claims description 7
- 238000004513 sizing Methods 0.000 claims description 7
- 230000003068 static effect Effects 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 238000005406 washing Methods 0.000 claims description 7
- 229940119224 salmon oil Drugs 0.000 claims description 6
- 241001125048 Sardina Species 0.000 claims description 5
- 241000269851 Sarda sarda Species 0.000 claims description 4
- 239000008280 blood Substances 0.000 abstract description 25
- 210000004369 blood Anatomy 0.000 abstract description 25
- 230000000694 effects Effects 0.000 abstract description 18
- 208000024172 Cardiovascular disease Diseases 0.000 abstract description 9
- 208000026106 cerebrovascular disease Diseases 0.000 abstract description 9
- 230000002526 effect on cardiovascular system Effects 0.000 abstract description 9
- 206010059866 Drug resistance Diseases 0.000 abstract description 7
- 230000004129 fatty acid metabolism Effects 0.000 abstract description 7
- 150000002632 lipids Chemical class 0.000 abstract description 4
- 210000004204 blood vessel Anatomy 0.000 abstract description 3
- 241001264174 Cordyceps militaris Species 0.000 abstract 1
- 240000008397 Ganoderma lucidum Species 0.000 abstract 1
- 235000001637 Ganoderma lucidum Nutrition 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 230000009084 cardiovascular function Effects 0.000 abstract 1
- 230000008455 cerebrovascular function Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 235000019197 fats Nutrition 0.000 description 15
- 241000251468 Actinopterygii Species 0.000 description 10
- 235000019688 fish Nutrition 0.000 description 10
- 235000013601 eggs Nutrition 0.000 description 9
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 7
- 229910052799 carbon Inorganic materials 0.000 description 7
- 239000003921 oil Substances 0.000 description 7
- 108090001030 Lipoproteins Proteins 0.000 description 6
- 102000004895 Lipoproteins Human genes 0.000 description 6
- 241000294142 Vascellum Species 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 230000004217 heart function Effects 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 230000004218 vascular function Effects 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 108010023302 HDL Cholesterol Proteins 0.000 description 3
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 235000020778 linoleic acid Nutrition 0.000 description 3
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 244000144972 livestock Species 0.000 description 3
- 238000002834 transmittance Methods 0.000 description 3
- 241000272525 Anas platyrhynchos Species 0.000 description 2
- 239000001828 Gelatine Substances 0.000 description 2
- 108010028554 LDL Cholesterol Proteins 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 239000013505 freshwater Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000017448 oviposition Effects 0.000 description 2
- 235000013594 poultry meat Nutrition 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 208000007442 rickets Diseases 0.000 description 2
- 150000004671 saturated fatty acids Chemical class 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 241000972773 Aulopiformes Species 0.000 description 1
- 108010007622 LDL Lipoproteins Proteins 0.000 description 1
- 102000007330 LDL Lipoproteins Human genes 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000001194 anti-hemostatic effect Effects 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 239000005667 attractant Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 210000004958 brain cell Anatomy 0.000 description 1
- 230000004641 brain development Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000031902 chemoattractant activity Effects 0.000 description 1
- 239000003026 cod liver oil Substances 0.000 description 1
- 235000012716 cod liver oil Nutrition 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000004626 essential fatty acids Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 108010022197 lipoprotein cholesterol Proteins 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 235000018343 nutrient deficiency Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 235000019512 sardine Nutrition 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 208000005494 xerophthalmia Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses fish oil soft capsules and a preparation method thereof. The fish oil soft capsules are prepared by fish oil, ganoderma lucidum, ginseng, oriental wormwood, honeysuckle, rhizoma alismatis, cordyceps militaris, salviae miltiorrhizae, gelatin, glycerin and water according to certain weight. The fish oil soft capsules have an evident blood lipid lowering effect and are capable of preventing cardiovascular and cerebrovascular diseases, softening and dredging blood vessels and lowering blood viscosity, free of side effects, high in safety, suitable for people of various ages, simple in preparation method, convenient to carry, capable of improving brain memory, promoting fatty acid metabolism and improving cardiovascular and cerebrovascular functions, and free of drug resistance generation.
Description
Technical field
The application belongs to field of health care products, particularly relates to a kind of fish oil soft capsule and preparation method thereof.
Background technology
Fish oil soft capsule is modern popular health products.It mainly extracts the fish body at deep-sea, and as salmon, sardine etc. are relatively good.Extract EPA, DHA completes.To the health effect of having greatly improved, the effective adjusting blood lipid of energy, reduces blood viscosity, prevents thrombosis, prevention cardiovascular and cerebrovascular disease; And can blood-brain barrier be passed through, activating brain cell, promote brain development, prevention senile dementia, improves eyesight, delays the decline of eyesight.
Lipoprotein cholesterol is divided into HDL-C and LDL-C, and the lower then particle of density of lipoprotein is larger.And LDL-C easily with other compositions endovascular in conjunction with adventitious deposit at blood vessel, be therefore called as " bad lipoprotein ".HDL-C then helps to reduce the cholesterol in blood, also praises title " good lipoprotein ".EPA in fish oil then can suppress the effect of bad lipoprotein, reduces the adventitious deposit on blood vessel, and HDL-C can be assisted to remove fat unnecessary on vascular wall, and therefore fish oil is also referred to as endovascular " street cleaner ".Not only can reducing blood lipid so take fish oil, and the generation of coronary heart disease and cranial vascular disease can be prevented.
It is preferred that the fish oil made with medical gelatine, its purity reaches 30%, and light transmittance, glossiness are fabulous, the bright spot having similar diamond equally shinny in the middle of printing opacity viewing is visible; More secondary is the fish oil made with hide glue, and purity can only reach 15%, and light transmittance, glossiness are poorer than gelatine, and center also loses shinny point; Worst is rubber polymer, and purity can only reach 5%, be faint in color unglazed, light transmittance is poor.
Linoleic acid contained by fish oil can affect the size of egg, but does not affect the oil content of fat total in yolk, but has influence on fat level and composition in liver.Linoleic acid is the key factor controlling lipoprotein synthesis in liver, and lipoprotein is by developing into bubble in blood transhipment arrival ovary, thus controls the size of egg, and practice shows, every plumage laying hen food linoleic acid 2.75 grams obviously increases egg size.In addition, in egg feedstuff, add fish oil, make cholesterol content in eggs decrease 20%, the cholesterol level in the blood in human body in liquid of this egg edible can not be changed, and edible common egg, cholesterol can increase.The laying rate of egg duck when egg-laying peak is generally about 80%, after peak period, laying rate then can be down to about 60%, it is reported that this phenomenon is relevant with fat, vitamin protein and amino acid nutrient deficiency in feed, and fish oil compensate for this point just, if add the fish oil of 2% in the daily ration after egg duck egg-laying peak, laying rate can be made to bring up to about 73%, and the average additional income of every plumage reaches 70%.The fish oil adding feed total amount 3% ~ 5% in feed manufacturing can improve feed nutrition, promote biological growth, improve aquaculture fish, livestock and poultry meat quality and prevent animal own fat too much.Moreover fish oil has strong fishlike smell, there is stronger attractant.In addition, fish oil contains a large amount of fat-soluble As and D, can ensure that livestock and poultry and aquatic livestock are to this requirement.
Aliphatic acid is the important composition of composition fat, and its chemical constitution is with the long-chain main body of carbon composition.The structure connected between carbon and carbon claims key, is connected the title saturated fatty acid being a key in aliphatic acid between carbon with carbon.All saturated fatty acids, can naturally synthesize in human body, do not need from food supplementary especially.If be doubly linked between carbon and carbon, then claim unrighted acid.The condition of synthesis unrighted acid is not possessed in human body, should by food supply, therefore unrighted acid is also referred to as essential fatty acid.
Deep sea fish oil is the extract from abyssal fishes fat.Main component is polybasic unsaturated fatty acid.The low-density lipoprotein in blood of human body can be reduced, reduce the stickiness of blood, anti-Hemostatic Oral Liquid Mottling formation, there is the booster action reducing blood fat, treatment cardiovascular and cerebrovascular disease.Cod-liver oil obtains from the liver of fish, belongs to medicine.Main component is vitamin A and vitamin D, for yctalopia, xerophthalmia, rickets, rickets and other A, D illnesss that is deficient in vitamin.Fish oil is the fish tallow deriving from ocean fish, freshwater fish, and there is bottled and capsule and pill goods sale in pharmacy.Though containing unrighted acid, it reduces the effect of human body blood fat, is far inferior to deep sea fish oil.Research confirms, no matter fresh-water fishes or ocean fish, allly propagate artificially with growth period short, its omega-3 content of fatty acid is all lower than self-sow.And though this content of fatty acid is less in fish oil, all higher than his food, and much lower than deep sea fish oil of nutritive value.But face and pollute and excessively hunt, deep-sea fish raw material is easily exhausted, cannot provide enough raw materials.And universal along with humanity concept, and the formation of novel harmonious society, design a kind of preparation method simple, can the fish oil soft capsule and preparation method thereof of reducing blood lipid be very important.
Summary of the invention
the technical problem solved:
The application, for above-mentioned technical problem, provides a kind of fish oil soft capsule and preparation method thereof, solves existing fish oil health products function singleness, easily the technical problem such as to have side effects.
technical scheme:
A kind of fish oil soft capsule, the raw materials by weight portion proportioning of described fish oil soft capsule is as follows: 100 parts, fish oil; Glossy ganoderma 2-8 part; Ginseng 4-8 part; Oriental wormwood 15-25 part; Honeysuckle 8-12 part; Rhizoma alismatis 2-6 part; Chinese caterpillar fungus 10-20 part; Red sage root 6-10 part; Gelatin 30-34 part; Glycerine is 9.5-13.5 part; Water 27.5-31.5 part.
As a preferred technical solution of the present invention: the raw materials by weight portion proportioning of described fish oil soft capsule is as follows: 100 parts, fish oil; Glossy ganoderma 3 parts; Ginseng 5 parts; Oriental wormwood 18 parts; Honeysuckle 9 parts; Rhizoma alismatis 3 parts; Chinese caterpillar fungus 13 parts; The red sage root 7 parts; 31 parts, gelatin; Glycerine is 10.5 parts; 28.5 parts, water.
As a preferred technical solution of the present invention: the raw materials by weight portion proportioning of described fish oil soft capsule is as follows: 100 parts, fish oil; Glossy ganoderma 7 parts; Ginseng 7 parts; Oriental wormwood 22 parts; Honeysuckle 11 parts; Rhizoma alismatis 5 parts; Chinese caterpillar fungus 17 parts; The red sage root 9 parts; 33 parts, gelatin; Glycerine is 12.5 parts; 30.5 parts, water.
As a preferred technical solution of the present invention: the raw materials by weight portion proportioning of described fish oil soft capsule is as follows: 100 parts, fish oil; Glossy ganoderma 5 parts; Ginseng 6 parts; Oriental wormwood 20 parts; Honeysuckle 10 parts; Rhizoma alismatis 4 parts; Chinese caterpillar fungus 15 parts; The red sage root 8 parts; 32 parts, gelatin; Glycerine is 11.5 parts; 29.5 parts, water.
As a preferred technical solution of the present invention: described fish oil adopts deep-sea salmon oil, deep-sea pilchard oil, deep-sea bonito stick oil or deep-sea tunny fish oil.
As a preferred technical solution of the present invention: the preparation method of described fish oil soft capsule, comprises the steps:
The first step: take fish oil, glossy ganoderma, ginseng, oriental wormwood, honeysuckle, rhizoma alismatis, Chinese caterpillar fungus, the red sage root, gelatin, G & W according to parts by weight proportioning;
Second step: be 300,000 grades at cleanliness factor, water joined in glue pot in the production area of temperature 18-26 DEG C, humidity 45-65%, when water temperature is increased to 76-80 DEG C, gelatin, glycerine are poured in glue pot, open Steam Heating valve, treat that temperature is increased to 74-78 DEG C, open mixer and stir 28-32 minute, after in tank, colloid all dissolves, open vavuum pump to find time, evacuation pressure is 0.06-0.1Mpa, when in tank during glue bubble-free, the glue filter-cloth filtering after vacuumizing, obtaining filtrate glue, putting to storing 55-65 DEG C of insulation in glue tank for subsequent use;
3rd step: the fish oil be up to the standards, glossy ganoderma, ginseng, oriental wormwood, honeysuckle, rhizoma alismatis, Chinese caterpillar fungus and the red sage root are put homogeneous in homogenizer;
4th step: the raw material after homogeneous and glue are connected to encapsulating machine, open cold blower fan, and then adjustment roll mould rotating speed is 3 revs/min, loading amount 1000mg/ grain;
5th step: the soft capsule suppressed is placed in sizing drying machine and carries out heat treatment, carry out natural drying in the hothouse pushing temperature 20 DEG C-26 DEG C, humidity 40%-48%;
6th step: wash ball with the ethanol of 95% in soft capsule washing machine; wash ball and be placed on clean dried indoor, static dry 24 hours, adopt lamp inspection machine to pick ball in lamp inspection case; get interior packaging material; by the soft capsule counting grain machine number be up to the standards, with sealing machine sealing, be wrapped inside dress by packing of product specification; obtain semi-finished product; get semi-finished product and outer packaging material, carry out external packing by packing of product specification, obtain finished product.
beneficial effect:
A kind of fish oil soft capsule of the present invention and preparation method thereof adopts above technical scheme compared with prior art, there is following technique effect: 1, there is significant effect for reducing blood fat, cardiovascular and cerebrovascular diseases can be prevented to occur, softening, dredging vascellum, reduce blood viscosity; 2, be free from side effects, security is high, is applicable to various age bracket; 3, preparation method is simple, easy to carry; 4, can memory be improved, can fatty acid metabolism be promoted, improve cardio and vascular function, can not drug resistance be produced, the widespread production not division of history into periods can replace current material.
Detailed description of the invention
embodiment 1:
Deep-sea tunny fish oil 100 parts is taken according to parts by weight proportioning; Glossy ganoderma 2 parts; Ginseng 4 parts; Oriental wormwood 15 parts; Honeysuckle 8 parts; Rhizoma alismatis 2 parts; Chinese caterpillar fungus 10 parts; The red sage root 6 parts; 30 parts, gelatin; Glycerine is 9.5 parts; 27.5 parts, water.
Be 300,000 grades at cleanliness factor, water joined in glue pot in the production area of temperature 18 DEG C, humidity 45%, when water temperature is increased to 76 DEG C, gelatin, glycerine are poured in glue pot, open Steam Heating valve, treat that temperature is increased to 74 DEG C, open mixer and stir 28 minutes, after in tank, colloid all dissolves, open vavuum pump to find time, evacuation pressure is 0.06Mpa, when in tank during glue bubble-free, the glue filter-cloth filtering after vacuumizing, obtaining filtrate glue, putting to storing 55 DEG C of insulations in glue tank for subsequent use.
The deep-sea tunny fish oil be up to the standards, glossy ganoderma, ginseng, oriental wormwood, honeysuckle, rhizoma alismatis, Chinese caterpillar fungus and the red sage root are put homogeneous in homogenizer, raw material after homogeneous and glue are connected to encapsulating machine, open cold blower fan, then adjustment roll mould rotating speed is 3 revs/min, loading amount 1000mg/ grain.
The soft capsule suppressed is placed in sizing drying machine and carries out heat treatment, in the hothouse pushing temperature 20 DEG C DEG C, humidity 40%, carry out natural drying; Ball is washed with the ethanol of 95% in soft capsule washing machine; wash ball and be placed on clean dried indoor, static dry 24 hours, adopt lamp inspection machine to pick ball in lamp inspection case; get interior packaging material; by the soft capsule counting grain machine number be up to the standards, with sealing machine sealing, be wrapped inside dress by packing of product specification; obtain semi-finished product; get semi-finished product and outer packaging material, carry out external packing by packing of product specification, obtain finished product.
There is significant effect for reducing blood fat, cardiovascular and cerebrovascular diseases can be prevented to occur, softening, dredging vascellum, reduce blood viscosity; Be free from side effects, security is high, is applicable to various age bracket; Preparation method is simple, easy to carry; Can memory be improved, can fatty acid metabolism be promoted, improve cardio and vascular function, can not drug resistance be produced.
embodiment 2:
Deep-sea bonito stick oil 100 parts is taken according to parts by weight proportioning; Glossy ganoderma 8 parts; Ginseng 8 parts; Oriental wormwood 25 parts; Honeysuckle 12 parts; Rhizoma alismatis 6 parts; Chinese caterpillar fungus 20 parts; The red sage root 10 parts; 34 parts, gelatin; Glycerine is 13.5 parts; 31.5 parts, water.
Be 300,000 grades at cleanliness factor, water joined in glue pot in the production area of temperature 26 DEG C, humidity 65%, when water temperature is increased to 80 DEG C, gelatin, glycerine are poured in glue pot, open Steam Heating valve, treat that temperature is increased to 78 DEG C, open mixer and stir 32 minutes, after in tank, colloid all dissolves, open vavuum pump to find time, evacuation pressure is 0.1Mpa, when in tank during glue bubble-free, the glue filter-cloth filtering after vacuumizing, obtaining filtrate glue, putting to storing 65 DEG C of insulations in glue tank for subsequent use.
The deep-sea bonito stick oil be up to the standards, glossy ganoderma, ginseng, oriental wormwood, honeysuckle, rhizoma alismatis, Chinese caterpillar fungus and the red sage root are put homogeneous in homogenizer, raw material after homogeneous and glue are connected to encapsulating machine, open cold blower fan, then adjustment roll mould rotating speed is 3 revs/min, loading amount 1000mg/ grain.
The soft capsule suppressed is placed in sizing drying machine and carries out heat treatment, in the hothouse pushing temperature 26 DEG C, humidity 48%, carry out natural drying; Ball is washed with the ethanol of 95% in soft capsule washing machine; wash ball and be placed on clean dried indoor, static dry 24 hours, adopt lamp inspection machine to pick ball in lamp inspection case; get interior packaging material; by the soft capsule counting grain machine number be up to the standards, with sealing machine sealing, be wrapped inside dress by packing of product specification; obtain semi-finished product; get semi-finished product and outer packaging material, carry out external packing by packing of product specification, obtain finished product.
There is significant effect for reducing blood fat, cardiovascular and cerebrovascular diseases can be prevented to occur, softening, dredging vascellum, reduce blood viscosity; Be free from side effects, security is high, is applicable to various age bracket; Preparation method is simple, easy to carry; Can memory be improved, can fatty acid metabolism be promoted, improve cardio and vascular function, can not drug resistance be produced.
embodiment 3:
Deep-sea pilchard oil 100 parts is taken according to parts by weight proportioning; Glossy ganoderma 3 parts; Ginseng 5 parts; Oriental wormwood 18 parts; Honeysuckle 9 parts; Rhizoma alismatis 3 parts; Chinese caterpillar fungus 13 parts; The red sage root 7 parts; 31 parts, gelatin; Glycerine is 10.5 parts; 28.5 parts, water.
Be 300,000 grades at cleanliness factor, water joined in glue pot in the production area of temperature 20 DEG C, humidity 50%, when water temperature is increased to 76-80 DEG C, gelatin, glycerine are poured in glue pot, open Steam Heating valve, treat that temperature is increased to 75 DEG C, open mixer and stir 29 minutes, after in tank, colloid all dissolves, open vavuum pump to find time, evacuation pressure is 0.07Mpa, when in tank during glue bubble-free, the glue filter-cloth filtering after vacuumizing, obtaining filtrate glue, putting to storing 58 DEG C of insulations in glue tank for subsequent use.
The deep-sea pilchard oil be up to the standards, glossy ganoderma, ginseng, oriental wormwood, honeysuckle, rhizoma alismatis, Chinese caterpillar fungus and the red sage root are put homogeneous in homogenizer, raw material after homogeneous and glue are connected to encapsulating machine, open cold blower fan, then adjustment roll mould rotating speed is 3 revs/min, loading amount 1000mg/ grain.
The soft capsule suppressed is placed in sizing drying machine and carries out heat treatment, in the hothouse pushing temperature 22 DEG C, humidity 42%, carry out natural drying; Ball is washed with the ethanol of 95% in soft capsule washing machine; wash ball and be placed on clean dried indoor, static dry 24 hours, adopt lamp inspection machine to pick ball in lamp inspection case; get interior packaging material; by the soft capsule counting grain machine number be up to the standards, with sealing machine sealing, be wrapped inside dress by packing of product specification; obtain semi-finished product; get semi-finished product and outer packaging material, carry out external packing by packing of product specification, obtain finished product.
There is significant effect for reducing blood fat, cardiovascular and cerebrovascular diseases can be prevented to occur, softening, dredging vascellum, reduce blood viscosity; Be free from side effects, security is high, is applicable to various age bracket; Preparation method is simple, easy to carry; Can memory be improved, can fatty acid metabolism be promoted, improve cardio and vascular function, can not drug resistance be produced.
embodiment 4:
Deep-sea salmon oil 100 parts is taken according to parts by weight proportioning; Glossy ganoderma 7 parts; Ginseng 7 parts; Oriental wormwood 22 parts; Honeysuckle 11 parts; Rhizoma alismatis 5 parts; Chinese caterpillar fungus 17 parts; The red sage root 9 parts; 33 parts, gelatin; Glycerine is 12.5 parts; 30.5 parts, water.
Be 300,000 grades at cleanliness factor, water joined in glue pot in the production area of temperature 24 DEG C, humidity 60%, when water temperature is increased to 79 DEG C, gelatin, glycerine are poured in glue pot, open Steam Heating valve, treat that temperature is increased to 77 DEG C, open mixer and stir 31 minutes, after in tank, colloid all dissolves, open vavuum pump to find time, evacuation pressure is 0.09Mpa, when in tank during glue bubble-free, the glue filter-cloth filtering after vacuumizing, obtaining filtrate glue, putting to storing 62 DEG C of insulations in glue tank for subsequent use.
The deep-sea salmon oil be up to the standards, glossy ganoderma, ginseng, oriental wormwood, honeysuckle, rhizoma alismatis, Chinese caterpillar fungus and the red sage root are put homogeneous in homogenizer, raw material after homogeneous and glue are connected to encapsulating machine, open cold blower fan, then adjustment roll mould rotating speed is 3 revs/min, loading amount 1000mg/ grain.
The soft capsule suppressed is placed in sizing drying machine and carries out heat treatment, in the hothouse pushing temperature 24 DEG C, humidity 46%, carry out natural drying; Ball is washed with the ethanol of 95% in soft capsule washing machine; wash ball and be placed on clean dried indoor, static dry 24 hours, adopt lamp inspection machine to pick ball in lamp inspection case; get interior packaging material; by the soft capsule counting grain machine number be up to the standards, with sealing machine sealing, be wrapped inside dress by packing of product specification; obtain semi-finished product; get semi-finished product and outer packaging material, carry out external packing by packing of product specification, obtain finished product.
There is significant effect for reducing blood fat, cardiovascular and cerebrovascular diseases can be prevented to occur, softening, dredging vascellum, reduce blood viscosity; Be free from side effects, security is high, is applicable to various age bracket; Preparation method is simple, easy to carry; Can memory be improved, can fatty acid metabolism be promoted, improve cardio and vascular function, can not drug resistance be produced.
embodiment 5:
Deep-sea salmon oil 100 parts is taken according to parts by weight proportioning; Glossy ganoderma 5 parts; Ginseng 6 parts; Oriental wormwood 20 parts; Honeysuckle 10 parts; Rhizoma alismatis 4 parts; Chinese caterpillar fungus 15 parts; The red sage root 8 parts; 32 parts, gelatin; Glycerine is 11.5 parts; 29.5 parts, water.
Be 300,000 grades at cleanliness factor, water joined in glue pot in the production area of temperature 22 DEG C, humidity 55%, when water temperature is increased to 78 DEG C, gelatin, glycerine are poured in glue pot, open Steam Heating valve, treat that temperature is increased to 76 DEG C, open mixer and stir 30 minutes, after in tank, colloid all dissolves, open vavuum pump to find time, evacuation pressure is 0.08Mpa, when in tank during glue bubble-free, the glue filter-cloth filtering after vacuumizing, obtaining filtrate glue, putting to storing 60 DEG C of insulations in glue tank for subsequent use.
The deep-sea salmon oil be up to the standards, glossy ganoderma, ginseng, oriental wormwood, honeysuckle, rhizoma alismatis, Chinese caterpillar fungus and the red sage root are put homogeneous in homogenizer, raw material after homogeneous and glue are connected to encapsulating machine, open cold blower fan, then adjustment roll mould rotating speed is 3 revs/min, loading amount 1000mg/ grain.
The soft capsule suppressed is placed in sizing drying machine and carries out heat treatment, in the hothouse pushing temperature 23 DEG C, humidity 44%, carry out natural drying; Ball is washed with the ethanol of 95% in soft capsule washing machine; wash ball and be placed on clean dried indoor, static dry 24 hours, adopt lamp inspection machine to pick ball in lamp inspection case; get interior packaging material; by the soft capsule counting grain machine number be up to the standards, with sealing machine sealing, be wrapped inside dress by packing of product specification; obtain semi-finished product; get semi-finished product and outer packaging material, carry out external packing by packing of product specification, obtain finished product.
There is significant effect for reducing blood fat, cardiovascular and cerebrovascular diseases can be prevented to occur, softening, dredging vascellum, reduce blood viscosity; Be free from side effects, security is high, is applicable to various age bracket; Preparation method is simple, easy to carry; Can memory be improved, can fatty acid metabolism be promoted, improve cardio and vascular function, can not drug resistance be produced.
Composition all components in above embodiment all can business be bought.
Above-described embodiment is just for setting forth content of the present invention, instead of restriction, and any change therefore in the implication suitable with claims of the present invention and scope, all should think to be included in the scope of claims.
Claims (6)
1. a fish oil soft capsule, is characterized in that the raw materials by weight portion proportioning of described fish oil soft capsule is as follows: 100 parts, fish oil; Glossy ganoderma 2-8 part; Ginseng 4-8 part; Oriental wormwood 15-25 part; Honeysuckle 8-12 part; Rhizoma alismatis 2-6 part; Chinese caterpillar fungus 10-20 part; Red sage root 6-10 part; Gelatin 30-34 part; Glycerine is 9.5-13.5 part; Water 27.5-31.5 part.
2. a kind of fish oil soft capsule according to claim 1, is characterized in that described fish oil soft capsule raw materials by weight portion proportioning is as follows: 100 parts, fish oil; Glossy ganoderma 3 parts; Ginseng 5 parts; Oriental wormwood 18 parts; Honeysuckle 9 parts; Rhizoma alismatis 3 parts; Chinese caterpillar fungus 13 parts; The red sage root 7 parts; 31 parts, gelatin; Glycerine is 10.5 parts; 28.5 parts, water.
3. a kind of fish oil soft capsule according to claim 1, is characterized in that the raw materials by weight portion proportioning of described fish oil soft capsule is as follows: 100 parts, fish oil; Glossy ganoderma 7 parts; Ginseng 7 parts; Oriental wormwood 22 parts; Honeysuckle 11 parts; Rhizoma alismatis 5 parts; Chinese caterpillar fungus 17 parts; The red sage root 9 parts; 33 parts, gelatin; Glycerine is 12.5 parts; 30.5 parts, water.
4. a kind of fish oil soft capsule according to claim 1, is characterized in that the raw materials by weight portion proportioning of described fish oil soft capsule is as follows: 100 parts, fish oil; Glossy ganoderma 5 parts; Ginseng 6 parts; Oriental wormwood 20 parts; Honeysuckle 10 parts; Rhizoma alismatis 4 parts; Chinese caterpillar fungus 15 parts; The red sage root 8 parts; 32 parts, gelatin; Glycerine is 11.5 parts; 29.5 parts, water.
5. a kind of fish oil soft capsule according to claim 1, is characterized in that: described fish oil adopts deep-sea salmon oil, deep-sea pilchard oil, deep-sea bonito stick oil or deep-sea tunny fish oil.
6. a preparation method for fish oil soft capsule described in claim 1, is characterized in that, comprises the steps:
The first step: take fish oil, glossy ganoderma, ginseng, oriental wormwood, honeysuckle, rhizoma alismatis, Chinese caterpillar fungus, the red sage root, gelatin, G & W according to parts by weight proportioning;
Second step: be 300,000 grades at cleanliness factor, water joined in glue pot in the production area of temperature 18-26 DEG C, humidity 45-65%, when water temperature is increased to 76-80 DEG C, gelatin, glycerine are poured in glue pot, open Steam Heating valve, treat that temperature is increased to 74-78 DEG C, open mixer and stir 28-32 minute, after in tank, colloid all dissolves, open vavuum pump to find time, evacuation pressure is 0.06-0.1Mpa, when in tank during glue bubble-free, the glue filter-cloth filtering after vacuumizing, obtaining filtrate glue, putting to storing 55-65 DEG C of insulation in glue tank for subsequent use;
3rd step: the fish oil be up to the standards, glossy ganoderma, ginseng, oriental wormwood, honeysuckle, rhizoma alismatis, Chinese caterpillar fungus and the red sage root are put homogeneous in homogenizer;
4th step: the raw material after homogeneous and glue are connected to encapsulating machine, open cold blower fan, and then adjustment roll mould rotating speed is 3 revs/min, loading amount 1000mg/ grain;
5th step: the soft capsule suppressed is placed in sizing drying machine and carries out heat treatment, carry out natural drying in the hothouse pushing temperature 20 DEG C-26 DEG C, humidity 40%-48%;
6th step: wash ball with the ethanol of 95% in soft capsule washing machine; wash ball and be placed on clean dried indoor, static dry 24 hours, adopt lamp inspection machine to pick ball in lamp inspection case; get interior packaging material; by the soft capsule counting grain machine number be up to the standards, with sealing machine sealing, be wrapped inside dress by packing of product specification; obtain semi-finished product; get semi-finished product and outer packaging material, carry out external packing by packing of product specification, obtain finished product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510635138.3A CN105192699A (en) | 2015-09-30 | 2015-09-30 | Fish oil soft capsules and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510635138.3A CN105192699A (en) | 2015-09-30 | 2015-09-30 | Fish oil soft capsules and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105192699A true CN105192699A (en) | 2015-12-30 |
Family
ID=54940970
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510635138.3A Pending CN105192699A (en) | 2015-09-30 | 2015-09-30 | Fish oil soft capsules and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105192699A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109349673A (en) * | 2018-10-22 | 2019-02-19 | 辽渔南极磷虾科技发展有限公司 | A kind of antarctic krill oil soft capsule peel, soft capsule and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE202007000949U1 (en) * | 2007-01-23 | 2007-04-12 | Vogel Lukas | Oral composition, useful for treating e.g. attention deficit disorder, comprises fish oil comprising omega-3- and/or omega-6-fatty acid, magnesium and zinc, optionally carriers and further auxiliary materials |
| CN101810336A (en) * | 2010-04-30 | 2010-08-25 | 广东仙乐制药有限公司 | Chewable soft capsules and method for preparing same |
| CN102948734A (en) * | 2011-08-23 | 2013-03-06 | 上海冠生园蜂制品有限公司 | Compound propolis soft-capsule for auxiliary reduction of blood sugar, and its preparation method |
| CN103349289A (en) * | 2013-06-14 | 2013-10-16 | 芜湖市诺康生物科技有限公司 | Preparation method of fish oil soft capsules |
-
2015
- 2015-09-30 CN CN201510635138.3A patent/CN105192699A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE202007000949U1 (en) * | 2007-01-23 | 2007-04-12 | Vogel Lukas | Oral composition, useful for treating e.g. attention deficit disorder, comprises fish oil comprising omega-3- and/or omega-6-fatty acid, magnesium and zinc, optionally carriers and further auxiliary materials |
| CN101810336A (en) * | 2010-04-30 | 2010-08-25 | 广东仙乐制药有限公司 | Chewable soft capsules and method for preparing same |
| CN102948734A (en) * | 2011-08-23 | 2013-03-06 | 上海冠生园蜂制品有限公司 | Compound propolis soft-capsule for auxiliary reduction of blood sugar, and its preparation method |
| CN103349289A (en) * | 2013-06-14 | 2013-10-16 | 芜湖市诺康生物科技有限公司 | Preparation method of fish oil soft capsules |
Non-Patent Citations (1)
| Title |
|---|
| 国家食品药品监督管理总局: "爱灵生乐牌鱼油灵芝孢子油软胶囊批", 《国家食品药品监督管理总局HTTP://APP2.SFDA.GOV.CN/DATASEARCHP/INDEX1.DO?TABLEID=30&TABLENAME=TABLE30&TABLEVIEW=国产保健食品&ID=7073》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109349673A (en) * | 2018-10-22 | 2019-02-19 | 辽渔南极磷虾科技发展有限公司 | A kind of antarctic krill oil soft capsule peel, soft capsule and preparation method thereof |
| CN109349673B (en) * | 2018-10-22 | 2021-10-08 | 辽渔南极磷虾科技发展有限公司 | Euphausia superba oil soft capsule shell, soft capsule and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101965878A (en) | Nutrient bean curd and preparation method thereof | |
| CN106727675A (en) | A kind of calcium-replenishing soft capsule and preparation method thereof | |
| US20160220521A1 (en) | Microcapsule fat powder of omega-3 enriched meat, egg and milk, and preparation method thereof | |
| CN110892936A (en) | Peony flower and black sesame pill and preparation method thereof | |
| CN103859368A (en) | Sea cucumber beverage and production method thereof | |
| CN103907935B (en) | A kind of alcohol molten tea powder flavour nutrient sausage and making method thereof | |
| CN106107620A (en) | A kind of Rhizoma amorphophalli stomach invigorating breaded fish stick and preparation method thereof | |
| CN105192699A (en) | Fish oil soft capsules and preparation method thereof | |
| RU2440765C2 (en) | Preserves production method | |
| CN108113000A (en) | A kind of preparation method of microalgae nutrition brown alga gel | |
| CN103989181A (en) | Walnut oil-containing fish oil soft capsule | |
| CN100488381C (en) | Propolis ganoderma lucidum spore, dried black fungus polysaccharide compounded soft capsule and preparing process therefor | |
| CN112450390A (en) | Fish sausage containing DHA microcapsules and preparation method thereof | |
| CN105580983A (en) | Production method of low-cholesterol-content EPA-enriched eggs | |
| CN104323190B (en) | A kind of Tricholoma matsutake (lto et lmai) Singer spicy complete feed of sauerkraut beef and mutton | |
| CN103989176B (en) | Deep-sea fish oil soft capsules containing kudzu root extract | |
| CN103689316A (en) | Processing method of sweet potato vermicelli | |
| CN103989180B (en) | Deep-sea fish oil soft capsules containing Salvia root P.E | |
| CN108112958A (en) | A kind of preparation process with shrimping beam trawl blachan | |
| CN101785550A (en) | Fish brain sauce condiment and processing technique thereof | |
| CN109259235A (en) | A kind of improvement eyesight promotes brain development cod liver oil soft capsule | |
| CN104705694A (en) | Blood pressure reduction alcohol-expelling kudzuvine root egg beancurd and making method thereof | |
| CN105851933A (en) | Preparation technology of health care pickled fish | |
| CN105942247A (en) | Spicy-hot-flavor fermented duck meat sausage and preparation method thereof | |
| CN105942263A (en) | Coconut juice sweet-fragrant fermented duck meat sausage and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20151230 |
|
| RJ01 | Rejection of invention patent application after publication |