CN105194338A - Traditional Chinese medicine composition for treating uterus cold and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating uterus cold and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating uterus cold. The traditional Chinese medicine composition consists of Chinese dodder seed, glossy privet fruit, esliptae herba, cuttlebone, Chinese angelica, fluorite, India madder root, refuse of deerhorn glue, palmleaf raspberry fruit, pulp of dogwood fruit, white peony root, dipsacus asper, Chinese taxillus twig, Chinese photinia leaf, herb of shorthorned epimedium, cassia twig, motherwort herb, medicinal cyathula root, Szechuan lovage rhizome, apricot seed, baical skullcap root and the like. Compared with the prior art, the traditional Chinese medicine composition has the advantages of good curative effect, low cost, small limitation and the like without adverse reactions. The traditional Chinese medicine composition has effects of warming yang to promote the flow of qi, consolidating body resistance to nourish essence, and regulating the Chong and Ren meridians, and has a good effect of treating the uterus cold. Compared with a same kind of medicines, the traditional Chinese medicine composition provided by the invention has the characteristics of strict compatibility, mild temperament and significant curative effect, and is convenient for clinical large-scale popularization application.
Description
Technical field
The invention belongs to technical field of traditional Chinese pharmacology, be specifically related to a kind of Chinese medicine composition for the treatment of cold womb and preparation method thereof.
Background technology
Cold womb is the abbreviation of " cold uterus " as its name suggests.Record at the document of Chinese medicine and there is no this entry in formal textbook and relevant TCM Gynecology monograph.But " cold womb " has become the hot word be rooted in the hearts of the people, also usually can be widely deployed in the daily life of today, especially most infertile women has deep impression and understanding from different approach to this word.Therefore, the implication of combing once this vocabulary is necessary." palace " can refer in " uterus " of western medicine, also can refer to " uterus " of Chinese medicine, and the more implication of the latter is general reference internal genital organs of female (uterus, fallopian tube, ovary) and function thereof.Therefore, " palace " is here interpreted as that " uterus " can contribute to understanding the implication of cold womb and the disease of indication better.
First " tremble with fear " in the traditional Chinese medical science is a common pathogenesis, namely greedyly coolly to paddle, all can cause external it by the Nature attacked by the cold and evil, voracious cold and cool food etc. and " tremble with fear " intrusion human body, be stuck in the passages through which vital energy circulates of human body, internal organs, certainly also comprise uterus, this preponderant cold is " excess-cold ".On the other hand, " tremble with fear " and in the traditional Chinese medical science, also to refer to that pathological product is coldly accumulate in human body passages through which vital energy circulates internal organs, the cold of this pathological product can by human splenocyte insufficiency of kidney-YANG, cannot normal transmitting and distributing the fluids and make cold and cool gas be stuck in human body passages through which vital energy circulates internal organs, and this preponderant cold is " deficiency and coldness ".So " cold womb " of broad sense, the endogenous cold of namely being given birth to due to external cold-evil or human splenocyte insufficiency of kidney-YANG is stuck in women's uterus, makes the function of uterus impaired and the general designation of a series of diseases of generation.
This word of cold womb by Chinese medicine sanctified by usage exclusive, therefore its morbidity is also that the morbidity theory of Traditional Chinese Medicine can make an explanation.Generally speaking can make the congenital deficiency of spleen-YANG and kidneyYANG of women because of the reason such as premature labor, miscarriage, deficiency of spleen-YANG and kidneyYANG can not the wet gas of water well in transporting body, so endogenous cold gathers; Also can because of the day after tomorrow reason as greedy coolly paddled, for a long time, cold and cool part is located in residence, menstrual period blow air-conditioning, voracious cold and cool food or directly suffer attacked by the cold and evil etc. in severe winter, external cold-evil condenses uterus and falls ill.Because of uterus general reference female internal genital organs, therefore various gynaecopathia can be seen occur, as pelvic inflammatory disease, endometriosis, postponed menstruation, Hypomenorrhea, amenorrhea, dysmenorrhea, vaginitis, miscarriage, puerperal abdonimal pain, postpartum lochiorrhea, infertile etc.
Because of different onset reason and different disease stage, cold womb can have multiple different clinical manifestation, as shown as having of menstrual phase disease in women through each side such as, pregnant, newborn, miscellaneous diseases: after Hypomenorrhea mistake, amenorrhea, menstrual period edema, menstrual period suffer from diarrhoea, dysmenorrhea; Show as pregnancy period disease can have: threatened abortion, habitual abortion, ectopic pregnancy etc.; Show as age of sucking disease can have: lochia is dripping not to the utmost, puerperal abdonimal pain etc.; Show that miscellaneous gynecological diseases can have: chronic pelvic pain, endometriosis, vaginitis, infertile etc.The traditional Chinese medical science judges that other general manifestation of cold also can have cold and pain in the lower abdomen, pain alleviated while getting warmth, is afraid of cold, hands and feet coolness, soreness of waist waist is cool, libido is indifferent, loose stool, and body of the tongue is dull, and tongue is white, and deep pulse is moistened.
Summary of the invention
In order to overcome deficiency of the prior art, the invention provides a kind of Chinese medicine composition for the treatment of cold womb, to cold womb, there is significant curative effect.
In order to solve the problems of the technologies described above, the technical solution used in the present invention is as follows: a kind of Chinese medicine composition for the treatment of cold womb, forms by with each component:
Semen Cuscutae, Fructus Ligustri Lucidi, Herba Ecliptae, Os Sepiae, Radix Angelicae Sinensis, Fluoritum, Radix Rubiae, Cornu Cervi Degelatinatum, Fructus Rubi, Fructus Corni, the Radix Paeoniae Alba, Radix Dipsaci, Herba Taxilli, Folium Photiniae (Folium Photiniae serrulatae), Herba Epimedii, Ramulus Cinnamomi, Herba Leonuri, Radix Cyathulae, Rhizoma Chuanxiong, Semen Armeniacae Amarum, Radix Scutellariae, Flos Lonicerae, Fructus Jujubae, Fructus Evodiae, Fructus Lycii, the Rhizoma Pinelliae, Radix Bupleuri, Folium Artemisiae Argyi, Cortex Cinnamomi, Medulla Tetrapanacis, Radix Polygalae, Radix Rehmanniae Preparata, Colla Corii Asini, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Asari, Fructus Cnidii.
As preferably, the present invention is made up of each component of following parts by weight:
Semen Cuscutae 1-30 part, Fructus Ligustri Lucidi 1-30 part, Herba Ecliptae 1-30 part, Os Sepiae 1-30 part, Radix Angelicae Sinensis 1-30 part, Fluoritum 1-30 part, Radix Rubiae 1-30 part, Cornu Cervi Degelatinatum 1-30 part, Fructus Rubi 1-30 part, Fructus Corni 1-30 part, Radix Paeoniae Alba 1-30 part, Radix Dipsaci 1-30 part, Herba Taxilli 1-30 part, Folium Photiniae (Folium Photiniae serrulatae) 1-30 part, Herba Epimedii 1-30 part, Ramulus Cinnamomi 1-30 part, Herba Leonuri 1-30 part, Radix Cyathulae 1-30 part, Rhizoma Chuanxiong 1-30 part, Semen Armeniacae Amarum 1-30 part, Radix Scutellariae 1-30 part, Flos Lonicerae 1-30 part, Fructus Jujubae 1-30 part, Fructus Evodiae 1-30 part, Fructus Lycii 1-30 part, Rhizoma Pinelliae 1-30 part, Radix Bupleuri 1-30 part, Folium Artemisiae Argyi 1-30 part, Cortex Cinnamomi 1-30 part, Medulla Tetrapanacis 1-30 part, Radix Polygalae 1-30 part, Radix Rehmanniae Preparata 1-30 part, Colla Corii Asini 1-30 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 1-30 part, Herba Asari 1-30 part, Fructus Cnidii 1-30 part.
As preferably, the present invention is made up of each component of following parts by weight:
Semen Cuscutae 1-20 part, Fructus Ligustri Lucidi 1-20 part, Herba Ecliptae 1-20 part, Os Sepiae 1-20 part, Radix Angelicae Sinensis 1-20 part, Fluoritum 1-20 part, Radix Rubiae 1-20 part, Cornu Cervi Degelatinatum 1-20 part, Fructus Rubi 1-20 part, Fructus Corni 1-20 part, Radix Paeoniae Alba 1-20 part, Radix Dipsaci 1-20 part, Herba Taxilli 1-20 part, Folium Photiniae (Folium Photiniae serrulatae) 1-20 part, Herba Epimedii 1-20 part, Ramulus Cinnamomi 1-20 part, Herba Leonuri 1-20 part, Radix Cyathulae 1-20 part, Rhizoma Chuanxiong 1-20 part, Semen Armeniacae Amarum 1-20 part, Radix Scutellariae 1-20 part, Flos Lonicerae 1-20 part, Fructus Jujubae 1-20 part, Fructus Evodiae 1-20 part, Fructus Lycii 1-20 part, Rhizoma Pinelliae 1-20 part, Radix Bupleuri 1-20 part, Folium Artemisiae Argyi 1-20 part, Cortex Cinnamomi 1-20 part, Medulla Tetrapanacis 1-20 part, Radix Polygalae 1-20 part, Radix Rehmanniae Preparata 1-20 part, Colla Corii Asini 1-20 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 1-20 part, Herba Asari 1-20 part, Fructus Cnidii 1-20 part.
As preferably, the present invention also comprises each component composition of following parts by weight: Rhizoma Zingiberis Recens 1-20 part, Cortex Moutan 1-20 part, Radix Ophiopogonis 1-20 part, Cortex Eucommiae 1-20 part.
As preferably, the dosage form of Chinese medicine preparation of the present invention is: suppository, ointment, vagina effervescence, soft capsule.
As preferably, present invention also offers the preparation method of the Chinese medicine composition for the treatment of cold womb, its preparation comprises the following steps:
(1) Semen Cuscutae, Fructus Ligustri Lucidi, Herba Ecliptae, Os Sepiae, Radix Angelicae Sinensis, Fluoritum, Radix Rubiae, Cornu Cervi Degelatinatum, Fructus Rubi, Fructus Corni, the Radix Paeoniae Alba are cleaned, put into container, add 5 times amount 80% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extract 2 times, each 50 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 80% ethanol elution, collect 4 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;
(2) by Radix Dipsaci, Herba Taxilli, Folium Photiniae (Folium Photiniae serrulatae), Herba Epimedii, Ramulus Cinnamomi, Herba Leonuri, Radix Cyathulae, Rhizoma Chuanxiong, Semen Armeniacae Amarum, Radix Scutellariae, Flos Lonicerae, Fructus Jujubae, CO is joined
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 6%, extracting pressure 20-30MPa, temperature 55 DEG C, CO
2flow 4ml/g crude drug min, extraction time 150min, obtains supercritical extract, for subsequent use;
(3) Fructus Evodiae, Fructus Lycii, the Rhizoma Pinelliae, Radix Bupleuri, Folium Artemisiae Argyi, Cortex Cinnamomi, Medulla Tetrapanacis, Radix Polygalae, Radix Rehmanniae Preparata, Colla Corii Asini, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Asari, the broken coarse powder of making of Fructus Cnidii are put in extractor, add dimethyl sulfoxide moistening again, carry out circumfluence distillation adding after water adds a cover 36 hours, the extracting solution extracted being added activated carbon adopts centrifuge to carry out solid-liquid separation decolouring removing dimethyl sulfoxide, the starch inside extracting solution is removed, pectin at membrane filtration; Add Polyethylene Glycol again, tween 80 potassium hydroxide, hydroxyethyl-cellulose, ethanol, static 8 hours of germall bp, centrifugalize is at normal temperatures decoloured, and obtains precipitate, and dry powder is for subsequent use;
(4) Rhizoma Zingiberis Recens, Cortex Moutan, Radix Ophiopogonis, the Cortex Eucommiae are cleaned, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, then add the water of 6 times amount, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;
(5) by above-mentioned steps (1), (2), (3), (4) gained mix homogeneously, then add excipient substance, be prepared into corresponding pharmaceutical dosage form.
As preferably, capsule preparation of the present invention comprises the following steps:
(1) Semen Cuscutae, Fructus Ligustri Lucidi, Herba Ecliptae, Os Sepiae, Radix Angelicae Sinensis, Fluoritum, Radix Rubiae, Cornu Cervi Degelatinatum, Fructus Rubi, Fructus Corni, the Radix Paeoniae Alba are cleaned, put into container, add 5 times amount 80% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extract 2 times, each 50 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 80% ethanol elution, collect 4 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;
(2) by Radix Dipsaci, Herba Taxilli, Folium Photiniae (Folium Photiniae serrulatae), Herba Epimedii, Ramulus Cinnamomi, Herba Leonuri, Radix Cyathulae, Rhizoma Chuanxiong, Semen Armeniacae Amarum, Radix Scutellariae, Flos Lonicerae, Fructus Jujubae, CO is joined
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 6%, extracting pressure 20-30MPa, temperature 55 DEG C, CO
2flow 4ml/g crude drug min, extraction time 150min, obtains supercritical extract, for subsequent use;
(3) Fructus Evodiae, Fructus Lycii, the Rhizoma Pinelliae, Radix Bupleuri, Folium Artemisiae Argyi, Cortex Cinnamomi, Medulla Tetrapanacis, Radix Polygalae, Radix Rehmanniae Preparata, Colla Corii Asini, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Asari, the broken coarse powder of making of Fructus Cnidii are put in extractor, add dimethyl sulfoxide moistening again, carry out circumfluence distillation adding after water adds a cover 36 hours, the extracting solution extracted being added activated carbon adopts centrifuge to carry out solid-liquid separation decolouring removing dimethyl sulfoxide, the starch inside extracting solution is removed, pectin at membrane filtration; Add Polyethylene Glycol again, tween 80 potassium hydroxide, hydroxyethyl-cellulose, ethanol, static 8 hours of germall bp, centrifugalize is at normal temperatures decoloured, and obtains precipitate, and dry powder is for subsequent use;
(4) Rhizoma Zingiberis Recens, Cortex Moutan, Radix Ophiopogonis, the Cortex Eucommiae are cleaned, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, then add the water of 6 times amount, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;
(5) by above-mentioned steps (1), (2), (3), (4) gained mix homogeneously, then add adhesive, carry out soft material granulation, granule is dried, add capsule adjuvant, after be distributed into capsule and be finished product, every capsules powder charge is about 10mg.
Theoretical foundation of the present invention:
Semen Cuscutae: nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.Suffer from a deficiency of the kidney rush down for impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness of the waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, frequent fetal movement, spleen kidney vaginal bleeding during pregnancy, frequent fetal movement, spleen; Externally treating leucoderma.Former medicine sieve is removed spare, picks decontamination, dry.
Fructus Ligustri Lucidi: nature and flavor: bitter sweet, flat.1. " herbal classic ": " bitter in the mouth is flat." 2. " not Lu ": " be sweet, nontoxic." return through: enter liver, kidney channel.1. " Bencao Jingshu ": " enter meridian of Foot-SHAO YIN." 2. " book on Chinese herbal medicine is new again ": " enters liver, lung, kidney three warp." function cures mainly: invigorating the liver and kidney, strong waist knee joint.Control yin asthenia generating intrinsic heat, dizzy, order flower, tinnitus, soreness of the waist and knees, early whitening of beard and hair.Nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.
Herba Ecliptae: abnormal smells from the patient: sweet in the mouth acid, cool in nature, enter Liver and kidney two warp, nontoxic.Cure mainly: nourishing the liver and kidney, cooling blood for hemostasis, various haematemesis can be controlled, the diseases such as enterorrhagia.Smash juice painting eyebrow to send out, can promote hair growth, for oral administration have black hair, hair color effect.Tang Materia Medica is said, Herba Ecliptae " main dysentery, acupuncture skin ulcer is sent out, big vast blood can not the person of stopping respect it ".Also say in " Japan hanako materia medica ", Herba Ecliptae can " logical small intestinal, applies all skin ulcers and silkworm Guo for evacuation of pus, hemostasis "." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries, Herba Ecliptae " teeth consolidating, black hair wash nine kinds of hemorrhoid ".Compendium of Material Medica is pointed out, Herba Ecliptae " black beard and hair, kidney tonifying is cloudy "." book on Chinese herbal medicine is stated " is thought, Herba Ecliptae " is treated hematuria and suffers from a deficiency of the kidney and become stranguria caused by overstrain ".Clinically, Herba Ecliptae is normal with the same use of Fructus Ligustri Lucidi, and Herba Ecliptae and Fructus Ligustri Lucidi have protecting the liver, the effect of transaminase of detoxifying, reduce, and can treat the hepatic and renal YIN deficiency, have a sleepless night vexed, tinnitus dizziness, the diseases such as soreness of the waist and knees.
Os Sepiae: nature and flavor with return through: salty, puckery, temperature.Return spleen, kidney channel.Function with cure mainly: astringing to arrest bleeding, treating spontaneous emission and leukorrhagia, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore.For Peptic Ulcers, hyperchlorhydria, hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge, stomachache acid regurgitation; External treatment bleeding due to trauma, the many pus of skin ulcer.Dehumidifying, antacid, hemostasis, sore.Treat for stomachache acid regurgitation, tells, is defeated in battle, hematemesis, has blood in stool, bleeding not during menses, amenorrhea due to blood depletion, stomachache lump in the abdomen, intermittent fever of deficiency type dysentery, the rotten skin ulcer of the erosion of the vulva.
Radix Angelicae Sinensis: nature and flavor: sweet, acrid, warm.Gui Jing: return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Fluoritum: nature and flavor: sweet, temperature.1. " herbal classic ": " sweet in the mouth, temperature." 2. " not Lu ": " be pungent, nontoxic." return through: enter the heart, Liver Channel.1. Materia Medica of Decoction: " start with few the moon, meridian of Foot-JUE YIN." 2. " book on Chinese herbal medicine is through separating ": " enters liver channel of foot-Jueyin, spleen meridian." function cures mainly: relieving palpitation, calms the nerves, lowering the adverse flow of QI, warm uterus.Control asthenia palpitation with fear, cough with dyspnea, women's sea of blood deficiency and coldness is infertile.
Radix Rubiae: nature and flavor: bitter, cold.Gui Jing: return Liver Channel.Function cures mainly: removing heat from blood and promoting blood circulation, and blood stasis dispelling stimulates the menstrual flow.For haematemesis, epistaxis, metrostaxis, traumatic hemorrhage, amenorrhea stasis blocking, arthralgia, tumbling and swelling.Cooling blood for hemostasis, blood circulation promoting and blood stasis dispelling: this product is stopped blooding and do not stay the stasis of blood, amenorrhea stomachache, traumatic injury hemorrhage for heat syndrome.Join Os Sepiae hemostasis power stronger.
Cornu Cervi Degelatinatum: nature and flavor: salty, temperature.1. " Elementary Medicine ": " salty in the mouth, prevents, nontoxic." 2. " medical center bun is wanted): " sweet salty, temperature." return through: enter liver, kidney channel.Function cures mainly: tonify deficiency, supporing yang.Control insufficiency of kidney-YANG, ache of the spinal column, Deficiency and coldness of spleen and stomach, vomiting, anorexia and loose stool, deficiency-cold of uterus, bleeding not during menses.
Fructus Rubi: nature and flavor: sweet, sour, temperature.Gui Jing: return kidney, urinary bladder channel.Function cures mainly: kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination.For enuresis due to deficiency of the kidney, frequent micturition, impotence and premature ejaculation, emission and spermatorrhea.
Fructus Corni: nature and flavor: acid, tepor.1. " herbal classic ": " sour in the mouth is flat." 2. " WU Pu Bencao ": " legendary god of farming, Yellow Emperor, a legendary ruler, Thunder God, Bian Que: acid, nontoxic.Qi primary: pungent." return through: enter liver, kidney channel.Function cures mainly: invigorating the liver and kidney, arresting seminal emission gas, Gu collapse.Control soreness of waist and knee joint, dizzy, tinnitus, sexual impotence, seminal emission, frequent micturition, deficiency of the liver cold and heat, incessant sweating due to debility, the heart shakes scattered pulse.
The Radix Paeoniae Alba: nature and flavor: bitter, sour, is slightly cold.Gui Jing: return liver, spleen channel.Function cures mainly: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Radix Dipsaci: nature and flavor: bitter, pungent, tepor.Gui Jing: return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, continuous injured, only metrorrhagia.For soreness of the waist and knees, rheumatic arthralgia, metrorrhagia, vaginal bleeding during pregnancy, injury from falling down.Prepared RADIX DIPSACI with yellow rice wine is used for rheumatic arthralgia, injury from falling down.Prepared RADIX DIPSACI with salt solution is used for soreness of the waist and knees.
Herba Taxilli: nature and flavor: bitter sweet is flat.1. " herbal classic ": " bitter, flat." 2. " not Lu ": " be sweet, nontoxic." 3. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " slightly warm in nature, bitter but sweet flavor." return through: enter liver, kidney channel.Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, except rheumatism, and the meridian dredging, beneficial blood, antiabortive.Control soreness of waist and knee joint, muscles and bones flaccidity is weak, hemiplegia, beriberi, anemofrigid-damp arthralgia, vaginal bleeding during pregnancy metrorrhagia, lack of lactation after delivery.
Folium Photiniae (Folium Photiniae serrulatae): nature and flavor: property is put down, acrid in the mouth, hardship; Slightly poisonous.Function cures mainly: the kidney invigorating of dispeling the wind.For bones and muscles pain due to rheumatism, impotence and seminal emission.
Herba Epimedii: nature and flavor: acrid, sweet, warm.Gui Jing: return liver, kidney channel.Function cures mainly: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.
Ramulus Cinnamomi: nature and flavor: acrid, sweet, warm.Gui Jing: GUIXIN, lung, urinary bladder channel.Function cures mainly: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Herba Leonuri: nature and flavor: bitter, pungent, is slightly cold.Gui Jing: return liver, pericardium channel.Function cures mainly: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.
Radix Cyathulae: nature and flavor: sweet, micro-hardship, flat.Gui Jing: return liver, kidney channel.Function cures mainly: eliminating blood stasis and inducing menstruation, easing joint movement, inducing diuresis for treating stranguria syndrome.For amenorrhea lump in the abdomen, retention of placenta, arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria stranguria with blood, injury from falling down.
Rhizoma Chuanxiong: nature and flavor: pungent, temperature.Gui Jing: return liver, gallbladder, pericardium channel.Function cures mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Semen Armeniacae Amarum: nature and flavor: bitter, temperature, poisonous.Gui Jing: enter lung, large intestine channel.Function cures mainly: expelling phlegm for arresting cough, relievings asthma, intestine moistening.Control exogenous cough, dyspnea with fullness of the chest, sore throat, dryness of the intestine constipation.
Radix Scutellariae: nature and flavor: bitter, cold.Gui Jing: return lung, gallbladder, spleen, large intestine, small intestine meridian.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Flos Lonicerae: nature and flavor: sweet, cold.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " cold in nature, bitter in the mouth." 2. " book on Chinese herbal medicine just ": " sweet in the mouth, gas is put down, its cold nature." return through: enter lung, stomach warp.1. " Thunder God concocts property of medicine solution ": " enter lung meridian." 2. " must join book on Chinese herbal medicine ": " enters bright, the Taiyin channels of foot sun." function cures mainly: heat clearing away, removing toxic substances.Control epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.
Fructus Jujubae: nature and flavor: sweet, temperature.Gui Jing: return spleen, stomach warp.Function cures mainly: really (Fructus Jujubae): invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.Bark: antiinflammatory, hemostasis, antidiarrheal.For tracheitis, enteritis, dysentery, metrorrhagia; Traumatic hemorrhage is controlled in external.Root: circulation of qi promoting, invigorates blood circulation, regulating menstruation.For menoxenia, redly to collapse, leucorrhea.
Fructus Evodiae: nature and flavor: pungent, bitter, heat; Slightly poisonous.Gui Jing: return liver, spleen, stomach, kidney channel.Function cures mainly: dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For headache due to JUE YIN disorder, colic of cold type is suffered from abdominal pain, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea, external treatment aphtha; Hypertension.
Fructus Lycii: nature and flavor: pungent, temperature.Gui Jing: return liver, gallbladder, pericardium channel.Function cures mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
The Rhizoma Pinelliae: nature and flavor: pungent, temperature; Poisonous.Gui Jing: return spleen, stomach, lung meridian.Function cures mainly: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, vomiting regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus; Raw with external treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI.
Radix Bupleuri: nature and flavor: bitter, is slightly cold.Gui Jing: return liver, gallbladder meridian.Function cures mainly: reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.
Folium Artemisiae Argyi: nature and flavor: pungent, bitter, temperature; Slightly poisonous.Gui Jing: return liver,spleen,kidney warp.Function cures mainly: dispersing cold for relieving pain, warming the meridian for stopping bleeding.For few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile, spit blood, epistaxis, metrorrhagia through many, gestation hemorrhage; External treatment skin pruritus.Vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding.Hemorrhage for deficient cold type.
Cortex Cinnamomi: nature and flavor: pungent, sweet, hot greatly.Gui Jing: return kidney, spleen, the heart, Liver Channel.Function cures mainly: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, dizziness due to yang deficiency, conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, and deficiency and coldness is vomited and diarrhoea, colic of cold type, renal mass, amenorrhea, dysmenorrhea.
Medulla Tetrapanacis: nature and flavor: sweet, light, is slightly cold.Gui Jing: attach to the lung and stomach meridians.Function cures mainly: clearing away heat and promoting diuresis, ventilation stimulating milk secretion.For hygropyrexia dark coloured urine, the puckery pain of gonorrhea, edema oliguria, agalactia.
Radix Polygalae: nature and flavor: bitter, pungent, warm.Gui Jing: GUIXIN, kidney, lung meridian.Function cures mainly: Fructus Alpiniae Oxyphyllae of calming the nerves, and eliminates the phlegm, detumescence.For the insomnia and dreamful sleep that disarmony between the heart and kidney causes, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.
Radix Rehmanniae Preparata: nature and flavor: sweet, tepor.Gui Jing: return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, and beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.
Colla Corii Asini: nature and flavor: sweet is flat.Gui Jing: return lung, liver, kidney channel.Function cures mainly: YIN nourishing of enriching blood, and moisturizes, hemostasis.For blood deficiency and yellow complexion, dizzy cardiopalmus, flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, and chronic cough is spat blood, haematemesis hematuria, metrorrhagia of having blood in stool, vaginal bleeding during pregnancy.
The Pseudobulbus Bletillae (Rhizoma Bletillae): nature and flavor: bitter sweet, cool.1. " herbal classic ": " bitter in the mouth is flat." 2. " WU Pu Bencao ": " legendary god of farming, Yellow Emperor, a legendary ruler: pungent.Li Shi: Great Cold.Thunder God: pungent is nontoxic." return through: enter lung meridian.1. " detailed outline ": " enter lung." 2. " book on Chinese herbal medicine is new again ": " enters lung, kidney two warp." function cures mainly: tonifying the lung, hemostasis, detumescence, granulation promoting, sore.Control lung and hinder hemoptysis, epistaxis, incised wound is hemorrhage, swollen ulcer drug, canker sores, and soup fire is burnt, rhagadia manus et pedis.
Herba Asari: nature and flavor: pungent, temperature.Gui Jing: GUIXIN, lung, kidney channel.Function cures mainly: expelling wind and cold, understand things pain-stopping, warming the lung to resolve fluid-retention.For anemofrigid cold, headache, toothache, nasal obstruction nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.
Fructus Cnidii: nature and flavor: arduous.Temperature.Gui Jing: enter kidney, spleen channel.Function cures mainly: warming the kidney to activate YANG, dispels the wind, dampness, parasite killing.Control impotence in male, scrotum pruritus due to damp pathogen, woman's leukorrhagia pudendal pruritus, cold uterus is infertile, rheumatic arthralgia, scabies eczema.
Rhizoma Zingiberis Recens: nature and flavor: pungent, temperature.Gui Jing: enter lung, stomach, spleen channel.Function cures mainly: deliver, cold expelling, and preventing or arresting vomiting opens expectorant.Cure cold wind and cold, vomiting, and phlegm retention, breathes with cough, and distension is had loose bowels; Separate the Rhizoma Pinelliae, Rhizoma Arisaematis and fish Eriocheir sinensis, birds and beasts meat poisoning.
Cortex Moutan: nature and flavor: bitter, pungent, is slightly cold.Gui Jing: GUIXIN, liver, kidney channel.Function cures mainly: clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.For maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, carbuncle sore tumefacting virus, falls and flutters the pain of injury.
Radix Ophiopogonis: nature and flavor: sweet, micro-hardship, is slightly cold.Gui Jing: GUIXIN, lung, stomach warp.Function cures mainly: YIN nourishing and the production of body fluid promoting, and lung moistening clears away heart-fire.For dryness of the lung dry cough.Chronic consumptive disease is coughed, and Tianjin wound is thirsty, vexed insomnia, and interior-heat is quenched one's thirst, dryness of the intestine constipation; Pharyngeal diphtheria.
The Cortex Eucommiae: nature and flavor: sweet, temperature.Gui Jing: return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, and bone and muscle strengthening is antiabortive.For lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Hypertension.
In sum, the present invention has the advantages such as good effect, cost is low, limitation is little, have no adverse reaction relative to prior art.Warming YANG activating QI of the present invention, consolidate and add essence, Chong and Ren Meridians regulating, treatment cold womb is effective.Compare with similar drugs, it is rigorous that medicine of the present invention has compatibility, mild in medicine property and, feature evident in efficacy, is convenient to large scale application clinically.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
Comprise following components by weight percent: Semen Cuscutae 1 part, Fructus Ligustri Lucidi 1 part, Herba Ecliptae 1 part, Os Sepiae 1 part, Radix Angelicae Sinensis 1 part, Fluoritum 1 part, 1 part, Radix Rubiae, Cornu Cervi Degelatinatum 1 part, Fructus Rubi 1 part, Fructus Corni 1 part, the Radix Paeoniae Alba 1 part, Radix Dipsaci 1 part, Herba Taxilli 1 part, Folium Photiniae (Folium Photiniae serrulatae) 1 part, Herba Epimedii 1 part, Ramulus Cinnamomi 1 part, Herba Leonuri 1 part, Radix Cyathulae 1 part, Rhizoma Chuanxiong 1 part, 1 part, Semen Armeniacae Amarum, Radix Scutellariae 1 part, Flos Lonicerae 1 part, 1 part, Fructus Jujubae, Fructus Evodiae 1 part, Fructus Lycii 1 part, the Rhizoma Pinelliae 1 part, Radix Bupleuri 1 part, Folium Artemisiae Argyi 1 part, Cortex Cinnamomi 1 part, Medulla Tetrapanacis 1 part, Radix Polygalae 1 part, Radix Rehmanniae Preparata 1 part, 1 part, Colla Corii Asini, the Pseudobulbus Bletillae (Rhizoma Bletillae) 1 part, Herba Asari 1 part, Fructus Cnidii 1 part, 1 part, Rhizoma Zingiberis Recens, Cortex Moutan 1 part, Radix Ophiopogonis 1 part, the Cortex Eucommiae 1 part.
The dosage form of Chinese medicine preparation described in the present embodiment is soft capsule.
The preparation method of the Chinese medicine composition of the present embodiment treatment cold womb, comprises the following steps:
(1) Semen Cuscutae, Fructus Ligustri Lucidi, Herba Ecliptae, Os Sepiae, Radix Angelicae Sinensis, Fluoritum, Radix Rubiae, Cornu Cervi Degelatinatum, Fructus Rubi, Fructus Corni, the Radix Paeoniae Alba are cleaned, put into container, add 5 times amount 80% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extract 2 times, each 50 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 80% ethanol elution, collect 4 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;
(2) by Radix Dipsaci, Herba Taxilli, Folium Photiniae (Folium Photiniae serrulatae), Herba Epimedii, Ramulus Cinnamomi, Herba Leonuri, Radix Cyathulae, Rhizoma Chuanxiong, Semen Armeniacae Amarum, Radix Scutellariae, Flos Lonicerae, Fructus Jujubae, CO is joined
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 6%, extracting pressure 20-30MPa, temperature 55 DEG C, CO
2flow 4ml/g crude drug min, extraction time 150min, obtains supercritical extract, for subsequent use;
(3) Fructus Evodiae, Fructus Lycii, the Rhizoma Pinelliae, Radix Bupleuri, Folium Artemisiae Argyi, Cortex Cinnamomi, Medulla Tetrapanacis, Radix Polygalae, Radix Rehmanniae Preparata, Colla Corii Asini, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Asari, the broken coarse powder of making of Fructus Cnidii are put in extractor, add dimethyl sulfoxide moistening again, carry out circumfluence distillation adding after water adds a cover 36 hours, the extracting solution extracted being added activated carbon adopts centrifuge to carry out solid-liquid separation decolouring removing dimethyl sulfoxide, the starch inside extracting solution is removed, pectin at membrane filtration; Add Polyethylene Glycol again, tween 80 potassium hydroxide, hydroxyethyl-cellulose, ethanol, static 8 hours of germall bp, centrifugalize is at normal temperatures decoloured, and obtains precipitate, and dry powder is for subsequent use;
(4) Rhizoma Zingiberis Recens, Cortex Moutan, Radix Ophiopogonis, the Cortex Eucommiae are cleaned, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, then add the water of 6 times amount, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;
(5) by above-mentioned steps (1), (2), (3), (4) gained mix homogeneously, then add adhesive, carry out soft material granulation, granule is dried, add capsule adjuvant, after be distributed into capsule and be finished product, every capsules powder charge is about 10mg.
Embodiment 2
Comprise following components by weight percent: Semen Cuscutae 1 part, Fructus Ligustri Lucidi 1 part, Herba Ecliptae 1 part, Os Sepiae 1 part, Radix Angelicae Sinensis 1 part, Fluoritum 1 part, 1 part, Radix Rubiae, Cornu Cervi Degelatinatum 1 part, Fructus Rubi 1 part, Fructus Corni 1 part, the Radix Paeoniae Alba 2 parts, Radix Dipsaci 1 part, Herba Taxilli 1 part, Folium Photiniae (Folium Photiniae serrulatae) 1 part, Herba Epimedii 1 part, Ramulus Cinnamomi 1 part, Herba Leonuri 2 parts, Radix Cyathulae 1 part, Rhizoma Chuanxiong 1 part, 2 parts, Semen Armeniacae Amarum, Radix Scutellariae 1 part, Flos Lonicerae 2 parts, 2 parts, Fructus Jujubae, Fructus Evodiae 1 part, Fructus Lycii 3 parts, the Rhizoma Pinelliae 1 part, Radix Bupleuri 1 part, Folium Artemisiae Argyi 3 parts, Cortex Cinnamomi 1 part, Medulla Tetrapanacis 1 part, Radix Polygalae 1 part, Radix Rehmanniae Preparata 1 part, 1 part, Colla Corii Asini, the Pseudobulbus Bletillae (Rhizoma Bletillae) 1 part, Herba Asari 1 part, Fructus Cnidii 1 part, 1 part, Rhizoma Zingiberis Recens, Cortex Moutan 2 parts, Radix Ophiopogonis 1 part, the Cortex Eucommiae 1 part.
The dosage form of Chinese medicine preparation described in the present embodiment is suppository.
The preparation method of the Chinese medicine composition of the present embodiment treatment cold womb, comprises the following steps:
(1) Semen Cuscutae, Fructus Ligustri Lucidi, Herba Ecliptae, Os Sepiae, Radix Angelicae Sinensis, Fluoritum, Radix Rubiae, Cornu Cervi Degelatinatum, Fructus Rubi, Fructus Corni, the Radix Paeoniae Alba are cleaned, put into container, add 5 times amount 80% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extract 2 times, each 50 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 80% ethanol elution, collect 4 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;
(2) by Radix Dipsaci, Herba Taxilli, Folium Photiniae (Folium Photiniae serrulatae), Herba Epimedii, Ramulus Cinnamomi, Herba Leonuri, Radix Cyathulae, Rhizoma Chuanxiong, Semen Armeniacae Amarum, Radix Scutellariae, Flos Lonicerae, Fructus Jujubae, CO is joined
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 6%, extracting pressure 20-30MPa, temperature 55 DEG C, CO
2flow 4ml/g crude drug min, extraction time 150min, obtains supercritical extract, for subsequent use;
(3) Fructus Evodiae, Fructus Lycii, the Rhizoma Pinelliae, Radix Bupleuri, Folium Artemisiae Argyi, Cortex Cinnamomi, Medulla Tetrapanacis, Radix Polygalae, Radix Rehmanniae Preparata, Colla Corii Asini, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Asari, the broken coarse powder of making of Fructus Cnidii are put in extractor, add dimethyl sulfoxide moistening again, carry out circumfluence distillation adding after water adds a cover 36 hours, the extracting solution extracted being added activated carbon adopts centrifuge to carry out solid-liquid separation decolouring removing dimethyl sulfoxide, the starch inside extracting solution is removed, pectin at membrane filtration; Add Polyethylene Glycol again, tween 80 potassium hydroxide, hydroxyethyl-cellulose, ethanol, static 8 hours of germall bp, centrifugalize is at normal temperatures decoloured, and obtains precipitate, and dry powder is for subsequent use;
(4) Rhizoma Zingiberis Recens, Cortex Moutan, Radix Ophiopogonis, the Cortex Eucommiae are cleaned, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, then add the water of 6 times amount, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;
(5) by above-mentioned steps (1), (2), (3), (4) gained mix homogeneously, be processed into according to the preparation method of suppository the suppository that weight is 1g.
Embodiment 3
Comprise following components by weight percent: Semen Cuscutae 1 part, Fructus Ligustri Lucidi 1 part, Herba Ecliptae 1 part, Os Sepiae 1 part, Radix Angelicae Sinensis 1 part, Fluoritum 1 part, 1 part, Radix Rubiae, Cornu Cervi Degelatinatum 1 part, Fructus Rubi 1 part, Fructus Corni 1 part, the Radix Paeoniae Alba 3 parts, Radix Dipsaci 1 part, Herba Taxilli 1 part, Folium Photiniae (Folium Photiniae serrulatae) 1 part, Herba Epimedii 1 part, Ramulus Cinnamomi 1 part, Herba Leonuri 3 parts, Radix Cyathulae 1 part, Rhizoma Chuanxiong 1 part, 2 parts, Semen Armeniacae Amarum, Radix Scutellariae 1 part, Flos Lonicerae 3 parts, 2 parts, Fructus Jujubae, Fructus Evodiae 1 part, Fructus Lycii 5 parts, the Rhizoma Pinelliae 1 part, Radix Bupleuri 2 parts, Folium Artemisiae Argyi 4 parts, Cortex Cinnamomi 1 part, Medulla Tetrapanacis 1 part, Radix Polygalae 1 part, Radix Rehmanniae Preparata 1 part, 1 part, Colla Corii Asini, the Pseudobulbus Bletillae (Rhizoma Bletillae) 1 part, Herba Asari 1 part, Fructus Cnidii 1 part, 2 parts, Rhizoma Zingiberis Recens, Cortex Moutan 2 parts, Radix Ophiopogonis 1 part, the Cortex Eucommiae 1 part.
The dosage form of Chinese medicine preparation described in the present embodiment is ointment.
The preparation method of the Chinese medicine composition of the present embodiment treatment cold womb, comprises the following steps:
(1) Semen Cuscutae, Fructus Ligustri Lucidi, Herba Ecliptae, Os Sepiae, Radix Angelicae Sinensis, Fluoritum, Radix Rubiae, Cornu Cervi Degelatinatum, Fructus Rubi, Fructus Corni, the Radix Paeoniae Alba are cleaned, put into container, add 5 times amount 80% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extract 2 times, each 50 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 80% ethanol elution, collect 4 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;
(2) by Radix Dipsaci, Herba Taxilli, Folium Photiniae (Folium Photiniae serrulatae), Herba Epimedii, Ramulus Cinnamomi, Herba Leonuri, Radix Cyathulae, Rhizoma Chuanxiong, Semen Armeniacae Amarum, Radix Scutellariae, Flos Lonicerae, Fructus Jujubae, CO is joined
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 6%, extracting pressure 20-30MPa, temperature 55 DEG C, CO
2flow 4ml/g crude drug min, extraction time 150min, obtains supercritical extract, for subsequent use;
(3) Fructus Evodiae, Fructus Lycii, the Rhizoma Pinelliae, Radix Bupleuri, Folium Artemisiae Argyi, Cortex Cinnamomi, Medulla Tetrapanacis, Radix Polygalae, Radix Rehmanniae Preparata, Colla Corii Asini, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Asari, the broken coarse powder of making of Fructus Cnidii are put in extractor, add dimethyl sulfoxide moistening again, carry out circumfluence distillation adding after water adds a cover 36 hours, the extracting solution extracted being added activated carbon adopts centrifuge to carry out solid-liquid separation decolouring removing dimethyl sulfoxide, the starch inside extracting solution is removed, pectin at membrane filtration; Add Polyethylene Glycol again, tween 80 potassium hydroxide, hydroxyethyl-cellulose, ethanol, static 8 hours of germall bp, centrifugalize is at normal temperatures decoloured, and obtains precipitate, and dry powder is for subsequent use;
(4) Rhizoma Zingiberis Recens, Cortex Moutan, Radix Ophiopogonis, the Cortex Eucommiae are cleaned, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, then add the water of 6 times amount, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;
(5) by above-mentioned steps (1), (2), (3), (4) gained mix homogeneously, be processed into as ointment according to the preparation method of ointment.
Toxicity test:
Laboratory animal
White mice is provided by Qingdao City's laboratory animal and animal experimental center.
Mice lavage administration acute toxicity testing
By 50 white mice in laboratory conditions adaptability feed after 3d, be divided into 2 groups at random, often organizing 25, is experimental group and matched group.After fasting 8h (can't help water), experimental group gives capsule of the present invention (capsule dissolves is obtained suspension in the water) gavage as embodiment 1 prepares, and matched group gives normal saline gavage.Observe the situation such as spirit, behavior, diet wish of white mice after gavage in seven days, record mice dying T/A, cuts open the dead white mice of inspection, observes the pathological change of each organs and tissues.Experimental result shows none death of white mice in seven days, and put to death each internal organs of white mice anatomic observation and do not find toxic reaction, experimental group and matched group white mice are without any difference.
Rat oral gavage administration long term toxicity test
Toxicity test:
Choose SD rat 80, be divided into matched group, experimental group often to organize 40, male and female half and half.Matched group adopts normal saline gavage, and experimental group adopts the present embodiment 1 capsules disperse in water, gavage, and dosage is 10g (crude drug) kg
-1(being equivalent to 100 times of adult's medication), three times on the one gavages, successive administration 15 weeks, observes the index such as animal ordinary circumstance and body weight.Drug withdrawal is after three days, and observe the index such as hair, behavior, defecation, body weight of SD rat, result shows all to have no significant effect, and internal organs naked eyes do not find difference change.Put to death rat, tissue slice is carried out to its internal organs, shows without any pathological changes and exception under Electronic Speculum.
Clinical trial:
Case selection:
As the medicine for the treatment of cold womb, select the routine clinical observation of cold womb patient 116 of making a definite diagnosis, the age 23-47 year, be all the cold uterus that degree is different.With the Chinese medicine composition of the embodiment of the present invention 2, each 1g, every day 3 times 5 days is 1 course for the treatment of.
Diagnostic criteria: menstruation is delayed, steps back ten days first quarter moons at least, two, three months at most.Very then see menstruation once (ultrasound diagnosis is many can not normally ovulate) in a year or so.How premenstrual little abdominal distention, pendant, blood color darkness, leucorrhoea grow in quantity, leucorrhea has fishy smell, and the acid of waist knee joint is cold, extremity are not warm.Two mammary swelling pains, breast is swollen, minority regurgitation, and pole of feeling sick is like conceived reaction.Menalgia, menstruation darkish complexion has clot.Few patients's dysmenorrhea reaches the degree being difficult to stand.Some conscious lower abdomen is cool, and whole body is sent out cool.
Criterion of therapeutical effect: effective: menstrual cycle recovers normal, menses color is scarlet, waist knee joint acid cold symptoms disappears, leucorrhea free from extraneous odour.Effective: waist knee joint acid cold symptoms disappears, and menstrual cycle recovers normal, menses color is scarlet but leucorrhea has fishy smell.Invalid: all symptoms of cold womb do not change.
Therapeutic outcome: the present invention treats 116 examples, effective 59 examples, effective 54 examples, invalid 3 examples, total effective rate 97.4%.
The above; it is only most preferred embodiment of the present invention; not any pro forma restriction is done to the present invention; any those of ordinary skill in the art; do not departing under technical solution of the present invention ambit; utilize the method content of above-mentioned announcement to make many possible variations and modification to technical solution of the present invention, all belong to the scope of claims protection.
Claims (7)
1. treat a Chinese medicine composition for cold womb, it is characterized in that: be made up of following component:
Semen Cuscutae, Fructus Ligustri Lucidi, Herba Ecliptae, Os Sepiae, Radix Angelicae Sinensis, Fluoritum, Radix Rubiae, Cornu Cervi Degelatinatum, Fructus Rubi, Fructus Corni, the Radix Paeoniae Alba, Radix Dipsaci, Herba Taxilli, Folium Photiniae (Folium Photiniae serrulatae), Herba Epimedii, Ramulus Cinnamomi, Herba Leonuri, Radix Cyathulae, Rhizoma Chuanxiong, Semen Armeniacae Amarum, Radix Scutellariae, Flos Lonicerae, Fructus Jujubae, Fructus Evodiae, Fructus Lycii, the Rhizoma Pinelliae, Radix Bupleuri, Folium Artemisiae Argyi, Cortex Cinnamomi, Medulla Tetrapanacis, Radix Polygalae, Radix Rehmanniae Preparata, Colla Corii Asini, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Asari, Fructus Cnidii.
2. a kind of Chinese medicine composition for the treatment of cold womb according to claim 1, is characterized in that: be made up of each component of following parts by weight:
Semen Cuscutae 1-30 part, Fructus Ligustri Lucidi 1-30 part, Herba Ecliptae 1-30 part, Os Sepiae 1-30 part, Radix Angelicae Sinensis 1-30 part, Fluoritum 1-30 part, Radix Rubiae 1-30 part, Cornu Cervi Degelatinatum 1-30 part, Fructus Rubi 1-30 part, Fructus Corni 1-30 part, Radix Paeoniae Alba 1-30 part, Radix Dipsaci 1-30 part, Herba Taxilli 1-30 part, Folium Photiniae (Folium Photiniae serrulatae) 1-30 part, Herba Epimedii 1-30 part, Ramulus Cinnamomi 1-30 part, Herba Leonuri 1-30 part, Radix Cyathulae 1-30 part, Rhizoma Chuanxiong 1-30 part, Semen Armeniacae Amarum 1-30 part, Radix Scutellariae 1-30 part, Flos Lonicerae 1-30 part, Fructus Jujubae 1-30 part, Fructus Evodiae 1-30 part, Fructus Lycii 1-30 part, Rhizoma Pinelliae 1-30 part, Radix Bupleuri 1-30 part, Folium Artemisiae Argyi 1-30 part, Cortex Cinnamomi 1-30 part, Medulla Tetrapanacis 1-30 part, Radix Polygalae 1-30 part, Radix Rehmanniae Preparata 1-30 part, Colla Corii Asini 1-30 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 1-30 part, Herba Asari 1-30 part, Fructus Cnidii 1-30 part.
3. according to a kind of Chinese medicine composition for the treatment of cold womb described in claim 1 to 2, it is characterized in that: be made up of each component of following parts by weight:
Semen Cuscutae 1-20 part, Fructus Ligustri Lucidi 1-20 part, Herba Ecliptae 1-20 part, Os Sepiae 1-20 part, Radix Angelicae Sinensis 1-20 part, Fluoritum 1-20 part, Radix Rubiae 1-20 part, Cornu Cervi Degelatinatum 1-20 part, Fructus Rubi 1-20 part, Fructus Corni 1-20 part, Radix Paeoniae Alba 1-20 part, Radix Dipsaci 1-20 part, Herba Taxilli 1-20 part, Folium Photiniae (Folium Photiniae serrulatae) 1-20 part, Herba Epimedii 1-20 part, Ramulus Cinnamomi 1-20 part, Herba Leonuri 1-20 part, Radix Cyathulae 1-20 part, Rhizoma Chuanxiong 1-20 part, Semen Armeniacae Amarum 1-20 part, Radix Scutellariae 1-20 part, Flos Lonicerae 1-20 part, Fructus Jujubae 1-20 part, Fructus Evodiae 1-20 part, Fructus Lycii 1-20 part, Rhizoma Pinelliae 1-20 part, Radix Bupleuri 1-20 part, Folium Artemisiae Argyi 1-20 part, Cortex Cinnamomi 1-20 part, Medulla Tetrapanacis 1-20 part, Radix Polygalae 1-20 part, Radix Rehmanniae Preparata 1-20 part, Colla Corii Asini 1-20 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 1-20 part, Herba Asari 1-20 part, Fructus Cnidii 1-20 part.
4. a kind of Chinese medicine composition for the treatment of cold womb according to claims 1 to 3, is characterized in that: each component composition also comprising following parts by weight: Rhizoma Zingiberis Recens 1-20 part, Cortex Moutan 1-20 part, Radix Ophiopogonis 1-20 part, Cortex Eucommiae 1-20 part.
5. a kind of Chinese medicine composition for the treatment of cold womb according to claim 1, is characterized in that: the dosage form of described Chinese medicine preparation is: suppository, ointment, vagina effervescence, soft capsule.
6., according to a kind of preparation method for the treatment of the Chinese medicine composition of cold womb described in claim 1 to 5, it is characterized in that: comprising the following steps of preparation:
(1) Semen Cuscutae, Fructus Ligustri Lucidi, Herba Ecliptae, Os Sepiae, Radix Angelicae Sinensis, Fluoritum, Radix Rubiae, Cornu Cervi Degelatinatum, Fructus Rubi, Fructus Corni, the Radix Paeoniae Alba are cleaned, put into container, add 5 times amount 80% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extract 2 times, each 50 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 80% ethanol elution, collect 4 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;
(2) by Radix Dipsaci, Herba Taxilli, Folium Photiniae (Folium Photiniae serrulatae), Herba Epimedii, Ramulus Cinnamomi, Herba Leonuri, Radix Cyathulae, Rhizoma Chuanxiong, Semen Armeniacae Amarum, Radix Scutellariae, Flos Lonicerae, Fructus Jujubae, CO is joined
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 6%, extracting pressure 20-30MPa, temperature 55 DEG C, CO
2flow 4ml/g crude drug min, extraction time 150min, obtains supercritical extract, for subsequent use;
(3) Fructus Evodiae, Fructus Lycii, the Rhizoma Pinelliae, Radix Bupleuri, Folium Artemisiae Argyi, Cortex Cinnamomi, Medulla Tetrapanacis, Radix Polygalae, Radix Rehmanniae Preparata, Colla Corii Asini, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Asari, the broken coarse powder of making of Fructus Cnidii are put in extractor, add dimethyl sulfoxide moistening again, carry out circumfluence distillation adding after water adds a cover 36 hours, the extracting solution extracted being added activated carbon adopts centrifuge to carry out solid-liquid separation decolouring removing dimethyl sulfoxide, the starch inside extracting solution is removed, pectin at membrane filtration; Add Polyethylene Glycol again, tween 80 potassium hydroxide, hydroxyethyl-cellulose, ethanol, static 8 hours of germall bp, centrifugalize is at normal temperatures decoloured, and obtains precipitate, and dry powder is for subsequent use;
(4) Rhizoma Zingiberis Recens, Cortex Moutan, Radix Ophiopogonis, the Cortex Eucommiae are cleaned, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, then add the water of 6 times amount, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;
(5) by above-mentioned steps (1), (2), (3), (4) gained mix homogeneously, then add excipient substance, be prepared into corresponding pharmaceutical dosage form.
7. a kind of preparation method for the treatment of the Chinese medicine composition of cold womb according to claim 6, is characterized in that: prepared by described capsule comprises the following steps:
(1) Semen Cuscutae, Fructus Ligustri Lucidi, Herba Ecliptae, Os Sepiae, Radix Angelicae Sinensis, Fluoritum, Radix Rubiae, Cornu Cervi Degelatinatum, Fructus Rubi, Fructus Corni, the Radix Paeoniae Alba are cleaned, put into container, add 5 times amount 80% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extract 2 times, each 50 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 80% ethanol elution, collect 4 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;
(2) by Radix Dipsaci, Herba Taxilli, Folium Photiniae (Folium Photiniae serrulatae), Herba Epimedii, Ramulus Cinnamomi, Herba Leonuri, Radix Cyathulae, Rhizoma Chuanxiong, Semen Armeniacae Amarum, Radix Scutellariae, Flos Lonicerae, Fructus Jujubae, CO is joined
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 6%, extracting pressure 20-30MPa, temperature 55 DEG C, CO
2flow 4ml/g crude drug min, extraction time 150min, obtains supercritical extract, for subsequent use;
(3) Fructus Evodiae, Fructus Lycii, the Rhizoma Pinelliae, Radix Bupleuri, Folium Artemisiae Argyi, Cortex Cinnamomi, Medulla Tetrapanacis, Radix Polygalae, Radix Rehmanniae Preparata, Colla Corii Asini, the Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Asari, the broken coarse powder of making of Fructus Cnidii are put in extractor, add dimethyl sulfoxide moistening again, carry out circumfluence distillation adding after water adds a cover 36 hours, the extracting solution extracted being added activated carbon adopts centrifuge to carry out solid-liquid separation decolouring removing dimethyl sulfoxide, the starch inside extracting solution is removed, pectin at membrane filtration; Add Polyethylene Glycol again, tween 80 potassium hydroxide, hydroxyethyl-cellulose, ethanol, static 8 hours of germall bp, centrifugalize is at normal temperatures decoloured, and obtains precipitate, and dry powder is for subsequent use;
(4) Rhizoma Zingiberis Recens, Cortex Moutan, Radix Ophiopogonis, the Cortex Eucommiae are cleaned, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, then add the water of 6 times amount, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;
(5) by above-mentioned steps (1), (2), (3), (4) gained mix homogeneously, then add adhesive, carry out soft material granulation, granule is dried, add capsule adjuvant, after be distributed into capsule and be finished product, every capsules powder charge is about 10mg.
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| CN106177744A (en) * | 2016-09-27 | 2016-12-07 | 成都市飞龙水处理技术研究所 | A kind of Chinese medicine composition and preparation method that can effectively treat cold womb |
| CN106362068A (en) * | 2016-11-30 | 2017-02-01 | 盛春正 | Medicine for treating weakness and chilling caused by yang deficiency |
| CN110548170A (en) * | 2018-06-01 | 2019-12-10 | 安徽舒源妇幼用品有限公司 | preparation method of antibacterial breathable postpartum care pad |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106177744A (en) * | 2016-09-27 | 2016-12-07 | 成都市飞龙水处理技术研究所 | A kind of Chinese medicine composition and preparation method that can effectively treat cold womb |
| CN106362068A (en) * | 2016-11-30 | 2017-02-01 | 盛春正 | Medicine for treating weakness and chilling caused by yang deficiency |
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