CN105194107A - Spirit-raising and refreshing drug and preparation method thereof - Google Patents
Spirit-raising and refreshing drug and preparation method thereof Download PDFInfo
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- CN105194107A CN105194107A CN201510708751.3A CN201510708751A CN105194107A CN 105194107 A CN105194107 A CN 105194107A CN 201510708751 A CN201510708751 A CN 201510708751A CN 105194107 A CN105194107 A CN 105194107A
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Abstract
The invention provides a spirit-raising and refreshing drug, which belongs to the field of medicine. The spirit-raising and refreshing drug comprises the following raw materials by weight: 1 to 5 parts of taurine, 20 to 40 parts of borneol, 5 to 25 parts of camphor, 20 to 50 parts of mint, 20 to 50 parts of menthol, 30 to 70 parts of aquilaria wood and alcohol with a volume concentration of 70 to 80%. The spirit-raising and refreshing drug provided by the invention has good persistence and good spirit-raising and refreshing effects and does not use any nervous centralis agonist, so toxic and side effects are effectively avoided. The invention further provides a preparation method for the spirit-raising and refreshing drug.
Description
Technical field
The present invention relates to field of medicaments, in particular to a kind of refreshing medicine and preparation method thereof.
Background technology
Along with China market rapid economic development, work and the rhythm of life of people are accelerated day by day, and increasing people is nervous and tired, easily enter a kind of state of subhealth state.While impact is healthy, also result in the reduction of study and work efficiency, easily occur the problems such as absent minded, work efficiency is poor.In order to keep a cool head in study or work, people usually utilize the product of resisting fatigue to carry out refreshment, and as by drinking coffee fatigue alleviating state, but long-term drink kaffeeklatsch produces dependency, and effect of refreshing oneself also can worse and worse, even also can be damaged healthy further.Market also has some other anti-fatigue product, but the persistence of most of anti-fatigue product is strong, refreshment effect is poor.
Summary of the invention
In view of this, the invention provides a kind of refreshing medicine and preparation method thereof, not strong to improve existing anti-fatigue product persistence, refreshment effect is poor, even may damage healthy problem further.
For achieving the above object, the invention provides following technical scheme:
A kind of refreshing medicine; raw material used comprises following component; count by weight, taurine 1 ~ 5 part, Borneolum Syntheticum 20 ~ 40 parts, Camphora 5 ~ 25 parts, Herba Menthae 20 ~ 50 parts, Mentholum 20 ~ 50 parts, Lignum Aquilariae Resinatum 30 ~ 70 parts and volumetric concentration are the ethanol of 70 ~ 80%.
Relative to prior art, the present invention includes following beneficial effect: the present invention take taurine as major ingredient, and taurine can improve nerve conduction function.In raw material with Borneolum Syntheticum, Camphora, Herba Menthae etc. for adjuvant; play effect of clearing away heat to improve acuity of vision, reducing swelling and alleviating pain, refreshment; with taurine synergism; the refreshing medicine obtained is refreshed oneself effective; by force, the persistent period is also long for resisting fatigue and oxidation resistance, can also improve the accuracy of memory and memory simultaneously; for study and work brings beneficial effect, improve learning efficiency or work efficiency.During use, this refreshing medicine can not only be refreshed oneself, and can also excite the generation of the phylloxanthin in retina and macular area, thus regulates dioptric, improves the phenomenons such as the visual field is fuzzy.
Avoid the use of the central nervous excitation agent such as caffeine in the component materials of this refreshing medicine, thus also just avoid the infringement to health that user brings its dependence and its.
Preferably, in above-mentioned refreshing medicine, described raw material also comprises eucalyptus oil 17 ~ 47 parts, Peppermint Oil 70 ~ 130 part, excipient 5000 ~ 9000 parts.Eucalyptus oil is added in raw material components, the abnormal smells from the patient of other raw material components can be made mutually to be in harmonious proportion on the one hand, make the refreshing medicine obtained have relatively mild abnormal smells from the patient, can also bactericidal action be played on the other hand.Oleum menthae has special cooling fragrance, is added to by Oleum menthae in raw material, can not only be in harmonious proportion abnormal smells from the patient further, can also strengthen refreshment effect simultaneously.Excipient can make refreshing medicine have specific form or character, by adding excipient in the feed, refreshing medicine can be made in tablet, semi-solid preparation, liquid preparation any one, meet the need of market.
Preferably, in above-mentioned refreshing medicine, described excipient comprise in emulsifying agent, lubricant and antiseptic one or more, the preferred glyceryl monostearate of described emulsifying agent, the preferred white vaseline of described lubricant, the preferred ethyl hydroxybenzoate of described antiseptic.Emulsifying agent can improve the various surface tension formed between phase in refreshing medicine, makes it to form uniform and stable dispersion, for solid molding is prepared; Lubricant can increase the mobility of the granule of solid-state refreshing medicine, simultaneously in the course of processing, can also prevent particle adhesion on drift, decrease the wearing and tearing of drift, punch die; Antiseptic can suppress corrupt.
Present invention also offers a kind of preparation method of above-mentioned refreshing medicine, described mixed raw material is become Chinese medicine preparation.
Preferably, in the preparation method of above-mentioned refreshing medicine, prepare described Chinese medicine preparation and comprise the following steps,
A. with ethanol, lixiviate is carried out to Borneolum Syntheticum, Camphora, Herba Menthae, Mentholum and Lignum Aquilariae Resinatum, obtain lixiviating solution;
B. by described lixiviating solution filter and remove residue, then taurine is dissolved in wherein, obtains product.
Utilize the raw material such as alcohol-pickled Borneolum Syntheticum, Camphora, Herba Menthae, the precipitation of effective ingredient in each raw material can be promoted, improve the content of active ingredient in lixiviating solution, improve extracting efficiency, and then make refreshing medicine have effect of refreshing oneself preferably.Do not relate to the interpolation of central nervous excitation agent in whole preparation process, effectively avoid toxic and side effects, human body does not also produce dependence to it after using.
Preferably, in the preparation method of above-mentioned refreshing medicine, the method for described lixiviate is further,
Step a1. Borneolum Syntheticum, Camphora, Herba Menthae, Mentholum and Lignum Aquilariae Resinatum all get the amount of 40 ~ 55%, then carry out lixiviate with the ethanol of whole amount to above-mentioned raw materials, obtain the first lixiviating solution;
Step a2. adds the Borneolum Syntheticum of surplus, Camphora, Herba Menthae, Mentholum and Lignum Aquilariae Resinatum in described first lixiviating solution, and heating lixiviate, obtains the second lixiviating solution.
Raw material is divided into two parts, separately adds, be integral medicinal Composition Control in order to make refreshing medicine contain within the specific limits, to make it have best effect of refreshing oneself.
Preferably, in the preparation method of above-mentioned refreshing medicine, also comprise after described step a1 He before described step a2: by purified water, described first lixiviating solution being diluted to percent by volume is 60 ~ 70%.Utilize purified water to dilute the first lixiviating solution, the odorousness of the first lixiviating solution can be reduced, thus reduce the Odor stimulation of obtained refreshing medicine.
Preferably, in the preparation method of above-mentioned refreshing medicine, the method heating lixiviate in described step a2 is: be first heated to 180 ~ 220 DEG C, then be incubated 8 ~ 12min.After the raw materials such as remaining Borneolum Syntheticum, Camphora are joined the first lixiviating solution, heat at 180 ~ 220 DEG C, the degrees of fusion of mixture can be made better.
Preferably, in the preparation method of above-mentioned refreshing medicine, also comprise after described step b: add 5000 ~ 9000 parts of excipient, be then heated to 150 ~ 170 DEG C, continue heating until become solid.By adding excipient, change the form of refreshing medicine, obtained solid-state refreshing medicine is easy to use and carry.
Preferably, in the preparation method of above-mentioned refreshing medicine, in described step a, lixiviate Borneolum Syntheticum, Camphora, Herba Menthae, Mentholum and Lignum Aquilariae Resinatum time, also add 17 ~ 47 parts of eucalyptus oils and 70 ~ 130 portions of Oleum menthae, carry out lixiviate.
In the present invention, ethanol is 2900 ~ 5500 parts, when utilizing alcohol-pickled raw material, ethanol gradation can be used, first taking part ethanol and carry out lixiviate to raw material, after lixiviate is filtered, then adds remaining ethanol, so, and the better effects if of obtained refreshing medicine.
Accompanying drawing explanation
In order to the clearer explanation embodiment of the present invention or technical scheme of the prior art, be briefly described to the accompanying drawing used required in embodiment or description of the prior art below, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skill in the art, under the prerequisite not paying creative work, other accompanying drawing can also be obtained according to these accompanying drawings.
Fig. 1 is the process chart preparing refreshing medicine that the embodiment of the present invention one provides;
Fig. 2 is the process chart preparing refreshing medicine that the embodiment of the present invention three provides.
Detailed description of the invention
Below by specific embodiment, the present invention is described in further detail.
Embodiment one
The refreshing medicine that the embodiment of the present invention one provides, raw materials by weight portion meter used, comprises the ethanol 2969 parts that taurine 1 part, Borneolum Syntheticum 20 parts, Camphora 5 parts, Herba Menthae 20 parts, Mentholum 20 parts, Lignum Aquilariae Resinatum 30 parts and volumetric concentration are 70%.
In the present embodiment, take taurine as major ingredient, taurine can improve nerve conduction function.In raw material with Borneolum Syntheticum, Camphora, Herba Menthae etc. for adjuvant; play effect of clearing away heat to improve acuity of vision, reducing swelling and alleviating pain, refreshment; with taurine synergism; the refreshing medicine obtained is refreshed oneself effective; by force, the persistent period is also long for resisting fatigue and oxidation resistance, can also improve the accuracy of memory and memory simultaneously; for study and work brings beneficial effect, improve learning efficiency or work efficiency.During use, this refreshing medicine can not only be refreshed oneself, and can also excite the generation of the phylloxanthin in retina and macular area, thus regulates dioptric, improves the phenomenons such as the visual field is fuzzy.
Avoid the use of the central nervous excitation agent such as caffeine in the component materials of this refreshing medicine, thus also just avoid the infringement to health that user brings its dependence and its.
See Fig. 1, the present embodiment additionally provides a kind of method preparing above-mentioned refreshing medicine, comprises the following steps,
A. by Borneolum Syntheticum, Camphora, Herba Menthae, Mentholum and Lignum Aquilariae Resinatum mixing, be divided into two parts, be labeled as mixture A and mixture B respectively, the quality of mixture A accounts for 45% of amount of the mixture;
B. select volumetric concentration be 70% ethanol, the ratio of ethanol and amount of the mixture is 50:1.6, ethanol is divided into the first ethanol and the second ethanol, and the quality of the first ethanol is 45% of ethanol total amount, the first ethanol is added in mixture A, stir, mixing, soaks 25 days, then filter gained mixture, remove slag, then add the second ethanol mixing, obtain mixture C;
C. in mixture C, add purified water, its volumetric concentration is diluted to 60%, the mixture C called after mixture D after dilution;
D. mixture D mixed with mixture B, gained mixture is heated to 180 DEG C, insulation 8min, obtains mixture E;
E., when thing E to be mixed is cooled to room temperature, it is mixed with taurine.
So, refreshing medicine is obtained.Do not relate to the interpolation of central nervous excitation agent in the whole production process of this medicine, effectively avoid toxic and side effects, human body does not also produce dependence to it after using.
Embodiment two
The refreshing medicine that the embodiment of the present invention two provides, raw materials by weight portion meter used, comprises the ethanol 3917 parts that taurine 5 parts, Borneolum Syntheticum 40 parts, Camphora 25 parts, Herba Menthae 50 parts, Mentholum 50 parts, Lignum Aquilariae Resinatum 70 parts and volumetric concentration are 80%.
The present embodiment additionally provides a kind of method preparing above-mentioned refreshing medicine, comprises the following steps,
A. by Borneolum Syntheticum, Camphora, Herba Menthae, Mentholum and Lignum Aquilariae Resinatum mixing;
B. select volumetric concentration be 80% ethanol, the ratio of ethanol and amount of the mixture is 50:3, in the mixture that step a obtains, add ethanol, stirs, and mixing, soaks 30 days, and then filtration gained mixture, removes slag;
C. the mixture that step b obtains is mixed with taurine.
Embodiment three
The refreshing medicine that the embodiment of the present invention three provides; raw materials by weight portion meter used, comprises the ethanol 5000 parts that taurine 3 parts, Borneolum Syntheticum 30 parts, Camphora 15 parts, Herba Menthae 35 parts, Mentholum 35 parts, Lignum Aquilariae Resinatum 50 parts, eucalyptus oil 32 parts, Oleum menthae 100 parts, glyceryl monostearate 2000 parts, white vaseline 2000 parts, ethyl hydroxybenzoate 2000 parts and volumetric concentration are 75%.
In the present embodiment, with the addition of eucalyptus oil and Oleum menthae in raw material, eucalyptus oil can make the abnormal smells from the patient of other raw material components mutually be in harmonious proportion on the one hand, makes the refreshing medicine obtained have relatively mild abnormal smells from the patient, can also play bactericidal action on the other hand; And Oleum menthae has special cooling fragrance, it can be in harmonious proportion abnormal smells from the patient further, can also strengthen effect of refreshment simultaneously.
In raw material components, with the addition of glyceryl monostearate, white vaseline, several excipient of ethyl hydroxybenzoate.Glyceryl monostearate can improve the various surface tension formed between phase in refreshing medicine, makes it to form uniform and stable dispersion, for solid molding is prepared; White vaseline can increase the mobility of the granule of solid-state refreshing medicine, simultaneously in the course of processing, can also prevent particle adhesion on drift, decrease the wearing and tearing of drift, punch die; Ethyl hydroxybenzoate is then used as antiseptic to be added in raw material.By the interpolation of above several excipient, make refreshing medicine to make solid forms, the refreshing medicine of solid forms is very easy to use, and is easy to carry about with one, and meets the market demand.
See Fig. 2, the present embodiment additionally provides a kind of method preparing above-mentioned refreshing medicine, comprises the following steps,
A. by Borneolum Syntheticum, Camphora, Herba Menthae, Mentholum, Lignum Aquilariae Resinatum, eucalyptus oil and Oleum menthae mix homogeneously, be labeled as mixture A and mixture B respectively, the quality of mixture A accounts for 50.5% of amount of the mixture;
B. select volumetric concentration be 75% ethanol, in a copy of it mixture, add ethanol; The mass ratio of ethanol and total mixture is 50:2.97, ethanol is divided into two parts, called after first ethanol and the second ethanol, mix the first ethanol with mixture A, fully stir, soak 30 days, the color of thing to be mixed becomes atrous from white, then filters gained mixture, removes slag, add the second ethanol mixing again, obtain mixture C;
C. in mixture C, add purified water, the volumetric concentration of mixture C is diluted to 65%, obtains mixture D;
D. in mixture D, add mixture B, fully stir, then gained mixture is heated to 200 DEG C, insulation 10min, obtains mixture E;
E. when thing E to be mixed is cooled to room temperature, adds taurine, fully stir, obtain mixture F;
F. in mixture F, add glyceryl monostearate, white vaseline and ethyl hydroxybenzoate, then continue to be heated to 160 DEG C, in thing to be mixed, moisture evaporation completely, namely obtains solid-state refreshing medicine.
In the preparation method that the present embodiment provides, first mixture is separated, then utilize the first alcohol-pickled mixture A, the medicinal ingredient in mixture A is made to dissolve, continue interpolation second ethanol again, separately adding of ethanol, the refreshing medicine obtained can be made to have effect of refreshing oneself preferably, and after obtaining mixture C, purified water is utilized to dilute it, reduce the odorousness of mixture C, reduce stimulation, the mixture D obtained mixes with mixture B again, make the degrees of fusion of the two better through heating, when the mixture E obtained is cooled to room temperature, be mixed into taurine again, effectively decrease the volatilization of taurine, make in mixture, to retain enough taurine compositions, last under excipient effect, obtained solid-state refreshing medicine, change the form of refreshing medicine, make refreshing medicine easy to use and carry.
Embodiment four
The refreshing medicine that the embodiment of the present invention four provides; raw materials by weight portion meter used, comprises the ethanol 3500 parts that taurine 4 parts, Borneolum Syntheticum 25 parts, Camphora 20 parts, Herba Menthae 40 parts, Mentholum 30 parts, Lignum Aquilariae Resinatum 55 parts, eucalyptus oil 40 parts, sorbitan fatty acid ester 3000 parts, castor oil hydrogenated 3000 parts, 2000 parts, benzoic acid and volumetric concentration are 78%.
The present embodiment additionally provides a kind of method preparing above-mentioned refreshing medicine, comprises the following steps,
A. by Borneolum Syntheticum, Camphora, Herba Menthae, Mentholum, Lignum Aquilariae Resinatum and eucalyptus oil mix homogeneously, be labeled as mixture A and mixture B respectively, the quality of mixture A accounts for 52% of amount of the mixture;
B. select volumetric concentration be 78% ethanol, in a copy of it mixture, add ethanol; The mass ratio of ethanol and total mixture is 50:3, ethanol is divided into two parts, a copy of it ethanol is mixed with mixture A, abundant stirring, soak 28 days, the color of thing to be mixed becomes atrous from white, then filter gained mixture, remove slag, then add another part of ethanol mixing, obtain mixture C;
C. in mixture C, add purified water, the volumetric concentration of mixture C is diluted to 61%, obtains mixture D;
D. in mixture D, add mixture B, fully stir, then gained mixture is heated to 210 DEG C, insulation 9min, obtains mixture E;
E. when thing E to be mixed is cooled to room temperature, adds taurine, fully stir, obtain mixture F;
F. in mixture F, add sorbitan fatty acid ester, castor oil hydrogenated and benzoic acid, then continue to be heated to 155 DEG C, in thing to be mixed, moisture evaporation completely, namely obtains solid-state refreshing medicine.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. a refreshing medicine; it is characterized in that: raw material used comprises following component; count by weight, taurine 1 ~ 5 part, Borneolum Syntheticum 20 ~ 40 parts, Camphora 5 ~ 25 parts, Herba Menthae 20 ~ 50 parts, Mentholum 20 ~ 50 parts, Lignum Aquilariae Resinatum 30 ~ 70 parts and volumetric concentration are the ethanol of 70 ~ 80%.
2. refreshing medicine according to claim 1, is characterized in that: described raw material also comprises eucalyptus oil 17 ~ 47 parts, Peppermint Oil 70 ~ 130 part, excipient 5000 ~ 9000 parts.
3. refreshing medicine according to claim 2, it is characterized in that: described excipient comprise in emulsifying agent, lubricant and antiseptic one or more, the preferred glyceryl monostearate of described emulsifying agent, the preferred white vaseline of described lubricant, the preferred ethyl hydroxybenzoate of described antiseptic.
4. a preparation method for the refreshing medicine described in any one of claims 1 to 3, is characterized in that: described mixed raw material is become Chinese medicine preparation.
5. the preparation method of refreshing medicine according to claim 4, is characterized in that: prepare described Chinese medicine preparation and comprise the following steps,
A. with ethanol, lixiviate is carried out to Borneolum Syntheticum, Camphora, Herba Menthae, Mentholum and Lignum Aquilariae Resinatum, obtain lixiviating solution;
B. by described lixiviating solution filter and remove residue, then taurine is dissolved in wherein, obtains product.
6. the preparation method of refreshing medicine according to claim 5, is characterized in that: the method for described lixiviate is further,
Step a1. Borneolum Syntheticum, Camphora, Herba Menthae, Mentholum and Lignum Aquilariae Resinatum all get the amount of 40 ~ 55%, then carry out lixiviate with the ethanol of whole amount to above-mentioned raw materials, obtain the first lixiviating solution;
Step a2. adds the Borneolum Syntheticum of surplus, Camphora, Herba Menthae, Mentholum and Lignum Aquilariae Resinatum in described first lixiviating solution, and heating lixiviate, obtains the second lixiviating solution.
7. the preparation method of refreshing medicine according to claim 6, is characterized in that: also comprise after described step a1 He before described step a2: by purified water, described first lixiviating solution being diluted to percent by volume is 60 ~ 70%.
8. the preparation method of refreshing medicine according to claim 6, is characterized in that: the method heating lixiviate in described step a2 is: be first heated to 180 ~ 220 DEG C, then be incubated 8 ~ 12min.
9. the preparation method of refreshing medicine according to claim 5, is characterized in that: also comprise after described step b: add 5000 ~ 9000 parts of excipient, be then heated to 150 ~ 170 DEG C, continues heating until become solid.
10. the preparation method of refreshing medicine according to claim 5, is characterized in that: in described step a, lixiviate Borneolum Syntheticum, Camphora, Herba Menthae, Mentholum and Lignum Aquilariae Resinatum time, also add 17 ~ 47 parts of eucalyptus oils and 70 ~ 130 portions of Oleum menthae, carry out lixiviate.
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| CN110269807A (en) * | 2018-03-14 | 2019-09-24 | 郁昌茂 | A kind of paper handkerchief and preparation method thereof with logical nose function of refreshing oneself |
| CN111700929A (en) * | 2020-06-15 | 2020-09-25 | 株洲千金药业股份有限公司 | Inhalant composition for refreshing and restoring consciousness, inhalant and preparation method |
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Application publication date: 20151230 |