CN105168121A - Diminazene compound for veterinary use and preparation method of diminazene compound - Google Patents
Diminazene compound for veterinary use and preparation method of diminazene compound Download PDFInfo
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- CN105168121A CN105168121A CN201510538518.5A CN201510538518A CN105168121A CN 105168121 A CN105168121 A CN 105168121A CN 201510538518 A CN201510538518 A CN 201510538518A CN 105168121 A CN105168121 A CN 105168121A
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- injection
- diminazene
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Abstract
The invention discloses a diminazene compound for veterinary use and a preparation method of the diminazene compound. The diminazene compound mainly comprises, by mass, 5-6% of diminazene, 2-6% of pyrazolone medicine, 4-6% of Vitamin B and the balance menstruum for injection. The diminazene compound has the advantages that the diminazene compound is quick to absorb by adoption of intramuscular injection delivery and high in bioavailability; the pyrazolone medicine and the Vitamin B are combined to achieve a synergistic effect, so that adverse reaction can be reduced; the Vitamin B supplements nutrient substances of organisms, enhances organism immunity and improves parasite resistance of the organisms; since resistance of the organisms is enhanced, a disease course can be shortened, dosage is reduced and appearance of parasites resistant to the diminazene compound is delayed.
Description
Technical field
The present invention relates to veterinary drug injection technical field, be specifically related to a kind of animal compound Diminazene Aceturate injection and preparation method thereof.
Background technology
Trichlorine amidine belongs to the two amidine class of fragrance, is the anti-Blood protozoan medicine of wide spectrum that tradition uses.As all having effect to domestic animal pyriform worm, trypanosomicide, limit worm and Eperythrozoon.For the domestic animal Babesia Gibsoni that caused by pyriform worm and theileriosis; The dehab caused by trypanosomicide and horse covering disease; The bloodprotozoonoses such as the eperythrozoonosis of domestic animal caused by genus Eperythrozoon.After medication, blood level is high, but the persistent period is shorter, therefore is mainly used in treatment, and preventive effect is poor.The mechanism of action of this product is by the DNA synthesis of selective exclusion polypide kinetoplast and copies, and produces irreversibility with core and be combined, thus the kinetoplast of polypide is disappeared, can not schizogamy, reaches the object for the treatment of.
The common drug of pyrazolone has aminophenazone, dipyrone, Phenylbutazone, crovaril etc., is all the derivant of phenazone.This class medicine has the mechanism of action suppressing prostaglandin synthesis.By suppressing maincenter prostaglandin synthetase, reducing the synthesis of maincenter prostaglandin, thus playing good refrigeration function.The animal heat of rising can be made to recover normal, and normal temperature decline can not be made; By suppressing the synthesis of periphery prostaglandin, and produce good analgesic activity.This class medicine can suppress Cycloxygenase, reduces synthesis and the release of prostaglandin, thus produces antiinflammatory, anti rheumatism action.
Vitamin B group is water soluble vitamins, all soluble in water, has found that vitamin B group has kind more than 20.Except vitamin B
12outward, water soluble vitamins stores hardly in vivo, and the part exceeding physiological need can excrete with urine quickly, and therefore prolonged application causes the probability of accumulate poisoning to be less than fatsoluble vitamin.Once heavy dose of use, can not cause toxic reaction usually.
Summary of the invention
The present invention proposes a kind of infiltration rate fast, bioavailability is high, can enhancing human body immunity power, and not easily produces the animal compound Diminazene Aceturate injection of drug resistance.
For achieving the above object, the invention provides following technical scheme:
The invention discloses a kind of Diminazene Aceturate injection for animals, the key component of this injection and mass percent thereof are:
Diminazene Aceturate 5% ~ 6%
Pyrazolone medicine 2% ~ 6%
Adenine phosphate % ~ 6%
Antioxidant 0.01% ~ 0.5%
Cosolvent 5% ~ 10%
Surplus is water for injection.
Further, described pyrazolone medicine is the one in phenazone, aminophenazone, dipyrone, Phenylbutazone, crovaril.
Further, described vitamin B is vitamin B
1, vitamin B
2, vitamin B
3, vitamin B
6, vitamin B
12, nicotinic acid, nicotiamide, one or more mixing in biotin.
Further, described solvent for injection is methanol, propylene glycol, PEG-4000, alpha-pyrrolidone, N-Methyl pyrrolidone, dimethyl formamide, dimethyl acetylamide, one or more mixed solvent of triacetyl glycerine.
Further, described injection also comprises antioxidant, antioxidant is one or more mixing in anhydrous sodium sulfite, sodium sulfite, sodium sulfite, sodium pyrosulfite, sodium thiosulfate, disodiumedetate, toluene di-tert-butyl phenol, BHA, nor-pair of hydrogen guaiaretic acid and gallic acid and ester thereof, and the mass percent of antioxidant in injection is 0.01% ~ 0.5%.
The present invention also discloses the preparation method of described Diminazene Aceturate injection for animals, first gets 40% water for injection and puts in preparation container, add, and stir, with the saturated 10min of nitrogen with appropriate water for injection after being dissolved by antioxidant; Add the vitamin B of full dose, pyrazolone medicine, Diminazene Aceturate while stirring, add the cosolvent of full dose after dissolving to be mixed, be stirred to and dissolve completely; Add to the full amount of water for injection 90%, with ethanolamine or glacial acetic acid adjusted to ph to 7.0 ~ 7.5, add to the full amount of water for injection, with the saturated 10min of nitrogen.After the inspection of semifinished product is qualified, by 0.22 μm of water system membrane filtration, fill, lamp inspection, labeling, packaging, obtains animal compound Diminazene Aceturate injection.
Beneficial effect of the present invention is:
The present invention is by Diminazene Aceturate, pyrazolone medicine and vitamin B reasonable compatibility prescription, effectively can kill domestic animal pyriform worm, trypanosomicide, the parasites such as limit worm and Eperythrozoon, effectively can prevent heating and the pain of the animal body caused by parasite, important water soluble vitamins can also be provided for animal body, regulate sugar, fat, protein metabolism, improve the situations such as malnutrition, therefore, injection of the present invention can treatment pyriform worm, trypanosomicide, the nutrient substance needed for body is supplemented in time during the parasitic infection such as limit worm and Eperythrozoon, enhancing human body immunity power, improve the pest-resistant power of body, both the course of disease can be shortened, also drug dose can be reduced, delay the appearance of drug-resistant worm plant.In addition, injection of the present invention: pyrazolone medicine and vitamin B used in combination, both can improve analgesic effect, can untoward reaction be reduced again; Add vitamin B, vitamin B is water soluble vitamins, regulates metabolism, maintains the health of skin and muscle, promotes immune system and neural function, Promote cell's growth and division.
Detailed description of the invention
In order to make object of the present invention, technical scheme and beneficial effect clearly, will be described in detail the preferred embodiments of the present invention below.
embodiment 1
Component and the mass percent thereof of the animal compound Diminazene Aceturate injection of the present embodiment are:
Diminazene Aceturate 5%
Phenazone 3%
Vitamin B
14%
Sodium sulfite 0.01%
Dimethyl acetylamide 5%
Surplus is water for injection.
The preparation method of the animal compound Diminazene Aceturate injection of the present embodiment is: first get 40% water for injection and put in preparation container, add, and stir, with the saturated 10min of nitrogen with appropriate water for injection after being dissolved by sodium sulfite; Add the vitamin B of full dose while stirring
1, phenazone, Diminazene Aceturate, to be dissolved completely after add the dimethyl acetylamide of full dose, add to the full amount of water for injection 90%, with ethanolamine or glacial acetic acid adjusted to ph to 7.0 ~ 7.5, add to the full amount of water for injection, with the saturated 10min of nitrogen.After the inspection of semifinished product is qualified, by 0.22 μm of water system membrane filtration, embedding, lamp inspection, labeling, packaging, obtains animal compound Diminazene Aceturate injection.
embodiment 2
Component and the mass percent thereof of the animal compound Diminazene Aceturate injection of the present embodiment are:
Diminazene Aceturate 5%
Dipyrone 3%
Vitamin B
24%
Sodium thiosulfate 0.1%
Propylene glycol 7%
Surplus is water for injection.
The preparation method of the animal compound Diminazene Aceturate injection of the present embodiment is: first get 40% water for injection and put in preparation container, add, and stir, with the saturated 10min of nitrogen with appropriate water for injection after being dissolved by sodium thiosulfate; Add the vitamin B of full dose while stirring
2, dipyrone, Diminazene Aceturate, add the propylene glycol of full dose after dissolving to be mixed, be stirred to and dissolve completely; Add to the full amount of water for injection 90%, with ethanolamine or glacial acetic acid adjusted to ph to 7.0 ~ 7.5, add to the full amount of water for injection, with the saturated 10min of nitrogen.After the inspection of semifinished product is qualified, by 0.22 μm of water system membrane filtration, embedding, lamp inspection, labeling, packaging, obtains Diminazene Aceturate injection for animals.
embodiment 3
Component and the mass percent thereof of the animal compound Diminazene Aceturate injection of the present embodiment are:
Diminazene Aceturate 6%
Dipyrone 3%
Vitamin B
34%
Triacetyl glycerine 10%
Disodiumedetate 0.01%
Surplus is water for injection.
The preparation method of the animal compound Diminazene Aceturate injection of the present embodiment is: first get 40% water for injection and put in preparation container, add, and stir, with the saturated 10min of nitrogen with appropriate water for injection after being dissolved by disodiumedetate; Add the vitamin B of full dose while stirring
3, dipyrone, Diminazene Aceturate, add the triacetyl glycerine of full dose after dissolving to be mixed, be stirred to and dissolve completely; Add to the full amount of water for injection 90%, with ethanolamine or glacial acetic acid adjusted to ph to 7.0 ~ 7.5, add to the full amount of water for injection, with the saturated 10min of nitrogen.After the inspection of semifinished product is qualified, with 0.22 μm of water system membrane filtration, embedding, 105 DEG C of steam sterilization 30min, lamp inspection, labeling, packaging, obtains Diminazene Aceturate injection for animals.
embodiment 4
Component and the mass percent thereof of the animal compound Diminazene Aceturate injection of the present embodiment are:
Diminazene Aceturate 5%
Phenylbutazone 4%
Vitamin B
65%
Methanol 5%
Anhydrous sodium sulfite 0.08%
Surplus is water for injection.
The preparation method of the animal compound Diminazene Aceturate injection of the present embodiment is: first get 40% water for injection and put in preparation container, add, and stir, with the saturated 10min of nitrogen with appropriate water for injection after being dissolved by anhydrous sodium sulfite; Add the vitamin B of full dose while stirring
6, Phenylbutazone, Diminazene Aceturate, add the methanol of full dose after dissolving to be mixed, be stirred to and dissolve completely; Add to the full amount of water for injection 90%, with ethanolamine or glacial acetic acid adjusted to ph to 7.0 ~ 7.5, add to the full amount of water for injection, with the saturated 10min of nitrogen.After the inspection of semifinished product is qualified, by 0.22 μm of water system membrane filtration, embedding, lamp inspection, labeling, packaging, obtains Diminazene Aceturate injection for animals.
embodiment 5
Component and the mass percent thereof of the animal compound Diminazene Aceturate injection of the present embodiment are:
Diminazene Aceturate 6%
Phenazone 3%
Nicotinic acid 5%
Sodium sulfite 0.01%
Disodiumedetate 0.02%
Triacetyl glycerine 7%
Surplus is water for injection.
The preparation method of the animal compound Diminazene Aceturate injection of the present embodiment is: first get 40% water for injection and put in preparation container, adds, and stir, with the saturated 10min of nitrogen with appropriate water for injection after disodiumedetate and sodium sulfite being dissolved; Add the nicotinic acid of full dose, phenazone, Diminazene Aceturate while stirring, add the triacetyl glycerine of full dose after dissolving to be mixed, be stirred to and dissolve completely; Add to the full amount of water for injection 90%, with ethanolamine or glacial acetic acid adjusted to ph to 7.0 ~ 7.5, add to the full amount of water for injection, with the saturated 10min of nitrogen.After the inspection of semifinished product is qualified, by 0.22 μm of water system membrane filtration, embedding, lamp inspection, labeling, packaging, obtains animal compound Diminazene Aceturate injection.
Claims (6)
1. an animal compound Diminazene Aceturate injection, is characterized in that: the key component of this injection and mass percent thereof are:
Diminazene Aceturate 5% ~ 6%
Pyrazolone medicine 2% ~ 6%
Adenine phosphate % ~ 6%
Antioxidant 0.01% ~ 0.5%
Cosolvent 5% ~ 10%
Surplus is water for injection.
2. animal compound Diminazene Aceturate injection according to claim 1, is characterized in that: described pyrazolone medicine is the one in phenazone, aminophenazone, dipyrone, Phenylbutazone, crovaril.
3. animal compound Diminazene Aceturate injection according to claim 1, is characterized in that: described vitamin B is vitamin B
1, vitamin B
2, vitamin B
3, vitamin B
6, vitamin B
12, nicotinic acid, nicotiamide, one or more mixing in biotin.
4. animal compound Diminazene Aceturate injection according to claim 1, is characterized in that: described solvent for injection is the mixed solvent of one or more in methanol, propylene glycol, PEG-4000, alpha-pyrrolidone, N-Methyl pyrrolidone, dimethyl formamide, dimethyl acetylamide, triacetyl glycerine.
5. the animal compound Diminazene Aceturate injection according to Claims 1-4, it is characterized in that: described injection also comprises antioxidant, antioxidant is one or more mixing in anhydrous sodium sulfite, sodium sulfite, sodium sulfite, sodium pyrosulfite, sodium thiosulfate, disodiumedetate, toluene di-tert-butyl phenol, BHA, nor-pair of hydrogen guaiaretic acid and gallic acid and ester thereof, and the mass percent of antioxidant in injection is 0.01% ~ 0.5%.
6. the compound recipe Diminazene Aceturate injection according to claim 1 to 5 any one, is characterized in that: first get 40% water for injection and put in preparation container, add, and stir, with the saturated 10min of nitrogen with appropriate water for injection after being dissolved by antioxidant; Add the vitamin B of full dose, pyrazolone medicine, Diminazene Aceturate while stirring, add the cosolvent of full dose after dissolving to be mixed, be stirred to and dissolve completely; Add to the full amount of water for injection 90%, with ethanolamine or glacial acetic acid adjusted to ph to 7.0 ~ 7.5, add to the full amount of water for injection, with the saturated 10min of nitrogen, after the inspection of semifinished product is qualified, with 0.22 μm of water system membrane filtration, fill, lamp inspection, labeling, packaging, obtains animal compound Diminazene Aceturate injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510538518.5A CN105168121A (en) | 2015-08-28 | 2015-08-28 | Diminazene compound for veterinary use and preparation method of diminazene compound |
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|---|---|---|---|
| CN201510538518.5A CN105168121A (en) | 2015-08-28 | 2015-08-28 | Diminazene compound for veterinary use and preparation method of diminazene compound |
Publications (1)
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|---|---|
| CN105168121A true CN105168121A (en) | 2015-12-23 |
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|---|---|---|---|
| CN201510538518.5A Pending CN105168121A (en) | 2015-08-28 | 2015-08-28 | Diminazene compound for veterinary use and preparation method of diminazene compound |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106974920A (en) * | 2017-01-02 | 2017-07-25 | 胡友忠 | Whole process is without vaccine livestock and poultry medicine |
| CN113577023A (en) * | 2021-07-19 | 2021-11-02 | 项黎丽 | Triazamidine suspension injection and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997006769A2 (en) * | 1995-08-21 | 1997-02-27 | Bourdichon Alain Jacques | Pharmaceutical composition with trypanocidal properties |
| CN1868483A (en) * | 2006-06-06 | 2006-11-29 | 江西省百思特动物药业有限公司 | Injection for treating eperythrozoonosis of domestic animal and its prepn. method |
| RU2296568C1 (en) * | 2005-07-25 | 2007-04-10 | Закрытое Акционерное Общество "Нита-Фарм" | Injection medicinal formulation for treatment and prophylaxis of blood-parasitic and invasion diseases |
| EP1638577B1 (en) * | 2003-06-03 | 2012-02-15 | Tropmed GmbH | Pharmaceutical preparation for treating tropical parasitic diseases containing diaminazen-diaceturate |
| CN102636582A (en) * | 2011-11-30 | 2012-08-15 | 河北科星药业有限公司 | Method for determining content of diminazene and antipyrine in diminazene particle |
-
2015
- 2015-08-28 CN CN201510538518.5A patent/CN105168121A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997006769A2 (en) * | 1995-08-21 | 1997-02-27 | Bourdichon Alain Jacques | Pharmaceutical composition with trypanocidal properties |
| EP1638577B1 (en) * | 2003-06-03 | 2012-02-15 | Tropmed GmbH | Pharmaceutical preparation for treating tropical parasitic diseases containing diaminazen-diaceturate |
| RU2296568C1 (en) * | 2005-07-25 | 2007-04-10 | Закрытое Акционерное Общество "Нита-Фарм" | Injection medicinal formulation for treatment and prophylaxis of blood-parasitic and invasion diseases |
| CN1868483A (en) * | 2006-06-06 | 2006-11-29 | 江西省百思特动物药业有限公司 | Injection for treating eperythrozoonosis of domestic animal and its prepn. method |
| CN102636582A (en) * | 2011-11-30 | 2012-08-15 | 河北科星药业有限公司 | Method for determining content of diminazene and antipyrine in diminazene particle |
Non-Patent Citations (1)
| Title |
|---|
| 中国兽药典委员会: "《中华人民共和国兽药典 一部》", 30 April 2006, 中国农业出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106974920A (en) * | 2017-01-02 | 2017-07-25 | 胡友忠 | Whole process is without vaccine livestock and poultry medicine |
| CN113577023A (en) * | 2021-07-19 | 2021-11-02 | 项黎丽 | Triazamidine suspension injection and preparation method thereof |
| CN113577023B (en) * | 2021-07-19 | 2022-09-23 | 项黎丽 | Triazamidine suspension injection and preparation method thereof |
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Application publication date: 20151223 |
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