CN105167882B - A kind of ultrahigh resolution retina prosthese and its means of communication - Google Patents
A kind of ultrahigh resolution retina prosthese and its means of communication Download PDFInfo
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- CN105167882B CN105167882B CN201510703087.3A CN201510703087A CN105167882B CN 105167882 B CN105167882 B CN 105167882B CN 201510703087 A CN201510703087 A CN 201510703087A CN 105167882 B CN105167882 B CN 105167882B
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Abstract
The present invention relates to a kind of ultrahigh resolution retina prosthese and its means of communication, its microelectrode matrix is assemblied on driving chip, the electrode of microelectrode matrix is connected respectively to the channel on driving chip, driving chip is connected to wireless chip by more connecting lines, a traditional stimulator chip is divided into two by the present invention, driving chip therein and microelectrode matrix are implanted into retina anteposition or bottom together, wireless chip is placed on the outside of sclera, so that the diameter of implant and the intermediate connections of sclera external equipment greatly reduces, therefore connection linear diameter is depended no longer in episcleral size incision when present invention implantation, but depend on the size of microelectrode, and microelectrode is by strict control in actual use, it is usually unilateral to be no more than 5mm, operative incision when implantation is small compared with the prior art and does not have to consider to increase stimulation channels Influence to notch reduces initiation infection and the too low risk of eyeball, can also increase channel and realize high-resolution visual effect.
Description
Technical field
The present invention relates to a kind of ultrahigh resolution retina prosthese and its means of communication, belong to biology doctor's electrical domain.
Background technique
WHO Report shows, 1.6 hundred million people's eyesights is had more than in world wide by different degrees of damage,
In, about 45,000,000 people suffer from blind disease.Clinical data shows retinal degenerative disease, such as retinal pigment degeneration (Rtinitis
Pigmentosa, RP), age-related maculopathy (Age-Related macularDegeneration, AMD) etc., be to cause
Blind principal disease.People attempt a variety of methods such as operation, drug and patient are helped to restore eyesight, but the effect of various methods at present
It is undesirable.It is shown according to clinical data: in the case of ablepsia patient, although macula area receptor almost completely loses,
The survival rate of macula area inner nuclear layer and ganglion-cell layer is still relatively high, respectively reaches 80% and 30%, by being implanted into retina prosthese,
It can be with recovered part vision.To phase late 1990s, retina prosthese is studied, prosthese is allowed to generate and external image information
Corresponding electrical stimulation signal stimulates and activates vision system, so that the patient for blinding or being on the verge of blindness be made to regain part
Useful eyesight becomes emerging research direction.
Retina prosthese is a kind of implantable bionic equipment.At present operation implantation retina prosthese in the world by
It is considered to restore the effective means of function for blind people eyesight, is that serious late retinal pigment degeneration (RP) and age related are yellow
The excellent selection of spot degeneration (AMD) patient.
The implantation body portion of usual retina prosthese is by a stimulator chip drives, the pixel that external equipment is captured
The image information of change is converted into corresponding stimulated current, inner retina is stimulated by a microelectrode matrix, in corresponding positions
It sets trigger action current potential (Action Potential) and corticocerebral visual centre is passed to by retina neural access,
To form image vision.Therefore, the quantity of stimulation channels is more, and resolution ratio is higher, and the image vision perception that brain generates is just
It is more clear.But increasing for stimulation channels quantity brings a technology bottle to the connection of stimulator chip and microelectrode matrix
Neck.Since the channel of stimulator chip and the electrode of microelectrode matrix are one-to-one relationships, hundreds and thousands of stimulations
Channel means to need hundreds and thousands of conducting wire connections between stimulator chip and microelectrode matrix.Microelectrode matrix is must to plant
Enter retina, it is meant that these conducting wires have to penetrate through wall of eyeball (sclera), even if these conducting wires can be made in a kind of multilayer
In the flexible cable (flexible cable) of structure, it is also difficult to excessive size is avoided, to cause too long operation
Notch increases initiation infection and the too low risk of intraocular pressure.
Summary of the invention
The technical problem to be solved by the present invention is in order to overcome the problems referred above, providing a kind of smaller superelevation of surgical wound point
Resolution retina prosthese and its means of communication.
The technical solution adopted by the present invention to solve the technical problems is:
A kind of ultrahigh resolution retina prosthese, including microelectrode matrix, the microelectrode matrix are assemblied in driving chip
On, the electrode of the microelectrode matrix is connected respectively to the channel on the driving chip, and the driving chip passes through more companies
Wiring is connected to wireless chip, and the driving chip and microelectrode matrix are implanted into retina anteposition or bottom together, described wireless
Chip is placed on the outside of sclera.
Preferably, the wireless chip includes Manchester encoder and reverse data decoder, the driving chip packet
Manchester decoder and reverse data encoder are included, the Manchester encoder is connected to described graceful by forward data line
Che Site decoder, the reverse data encoder are connected to the inversely decoding device by reverse data line.
Preferably, the forward data line includes two data lines, and the reverse data line is a data wire.
Preferably, common return electrode cable is also connected between the wireless chip and driving chip.
Preferably, consumption electrode cable is also connected between the wireless chip and driving chip.
Preferably, the wireless chip further includes rectification circuit and current stabilization circuit, and the rectification circuit is connected to coil, institute
It states current stabilization circuit and is connected to the Manchester encoder.
Preferably, the forward data line is also connected on the power module in the driving chip, the power module
Also it is connect with the Manchester decoder.
A kind of means of communication of above-mentioned resolution ratio retina prosthese, comprising the following steps:
S1: the wireless chip receives the wireless power source and data-signal of external equipment transmission, and encodes and generate difference volume
Code data are transferred to the driving chip；
S2: the driving chip decodes initial data and system clock from the differential encoded data；
S3: it is sent to the wireless chip after the reverse data coding that the driving chip is also generated, and by described
The external equipment is sent to after wireless chip decoding.
Preferably, the differential encoded data is the data using Differential Manchester Encoding.
Preferably, the reverse data is the data encoded using positive negative pulse stuffing.
The beneficial effects of the present invention are: depending on the big of microelectrode in episcleral size incision when (1) present invention implantation
It is small, and microelectrode is by strict control in actual use, usually unilateral to be no more than 5mm, operative incision when implantation is more existing
There is technology small and do not have to the quantity and size for considering that increase stimulation channels will increase connecting wire, significantly reduces initiation sense
Dye and the too low risk of eyeball, can also be achieved high-resolution visual effect.
(2) present invention is communicated using Manchester's code and positive negative pulse stuffing coding, due to Manchester's code and just
The characteristic of negative pulse coding, will not generate charge accumulated on conducting wire, thus will not be right in the case where wire insulation breakage
Tissue causes irreversible damage.
Detailed description of the invention
Present invention will be further explained below with reference to the attached drawings and examples.
Fig. 1 is a kind of schematic diagram of ultrahigh resolution retina prosthese one embodiment of the present invention；
Fig. 2 is a kind of electrical block diagram of ultrahigh resolution retina prosthese one embodiment of the present invention；
Fig. 3 is the flow chart of the means of communication of the present invention；
Marked in the figure: 1- wireless chip, 2- driving chip, 3- connecting line, 4- notch, 5- sclera, 6- coil, 7- view
Film, 11- microelectrode matrix, 12- rectification circuit, 13- stabilizing circuit, 14- Manchester encoder, 15- reverse data decoder,
16- power module, 17- Manchester decoder, 18- reverse data encoder, 22- forward data line, 23- reverse data line,
24- common return electrode cable, 25- consume electrode cable.
Specific embodiment
In conjunction with the accompanying drawings, the present invention is further explained in detail.These attached drawings are simplified schematic diagram, only with
Illustration illustrates basic structure of the invention, therefore it only shows the composition relevant to the invention.
Embodiment 1
A kind of ultrahigh resolution retina prosthese of the present invention as shown in Figure 1, existing retina prosthese include more
Kind, the present invention is implanted prosthese, needs to be implanted into retina 7, wherein microelectrode matrix 11 of the present invention is implanted into 7 anteposition of retina
(epi-retinal) or it is the next (sub-retinal), it gives optic nerve stimulation and activates vision system, the microelectrode matrix
11 can be used existing microelectrode matrix 11, and without specifically limiting, in the present embodiment, the microelectrode matrix 11 passes through core
Piece flip chip technology is assemblied on driving chip 2, and the electrode of the microelectrode matrix 11 is connected respectively on the driving chip 2
Channel, the driving chip 2 are connected to wireless chip 1 by more connecting lines 3, in the prior art will be only by microelectrode matrix 11
It is implanted into retina 7, the stimulating chip of connection, when needing to realize high-resolution visual effect, is needed micro- outside sclera 5
Increase stimulation channels between electrode matrix 11 and stimulating chip, and need to increase conducting wire, so notch when implantation on sclera 5
4 can increase because of increasing for number of conductors, fall into the bigger vicious circle of the more clear then operative incision 4 of visual effect.
Therefore traditional stimulating chip is divided into two chip-wireless chips 1 and driving chip 2 in the present invention, wherein without
Core piece 1 is not implanted into retina 7, and driving chip 2 is then implanted into retina 7 together with microelectrode matrix 11, due to driving core
Piece 2 uses fine deep submicron process, can keep suitable with microelectrode matrix 11 while integrating a large amount of stimulation channels
Or smaller size, therefore 4 size of notch when implantation on sclera 5 depends on the size of microelectrode, rather than as existing skill
The thickness of connecting line is depended in art, and microelectrode is to be no more than 5mm by unilateral by strict control in actual use,
So the operative incision 4 when the present invention is implanted into is small compared with the prior art and does not have to consider to increase influence of the stimulation channels to notch 4,
Initiation infection and the too low risk of eyeball are significantly reduced, can also be achieved high-resolution visual effect.
Embodiment 2
On the basis of the ultrahigh resolution retina prosthese described in embodiment 1, as shown in Fig. 2, in the present embodiment
Wireless chip 1 includes Manchester encoder 14 and reverse data decoder 15, and the driving chip 2 includes manchester decoder
Device 17 and reverse data encoder 18, the Manchester encoder 14 are connected to described Manchester by forward data line 22
Decoder 17, the forward data line 22 at least includes two data lines.Because the forward data line 22 is using Man Chesi
Spy's coding, therefore single wire transmission theoretically may be implemented in it.But the power module 16 of driving chip 2 needs differential signal to input
DC power supply can be just recovered, to need two wire transmissions.Therefore most preferably two forward data lines 22 merge number
According to and power supply input signal, i.e., the Differential Manchester Encoding signal transmitted on this two data lines at the same be used as data-signal with
Power supply input signal uses.Specifically can also according to practical effect and demand in the case where not influencing notch 4 by preceding to number
It is separated according to line 22 with differential power input line.
The reverse data encoder 18 is connected to the inversely decoding device, the reverse data by reverse data line 23
Line 23 is a data wire, therefore the present invention is at least connected by three data lines between wireless chip 1 and driving chip 2,
It can be smaller on being influenced at notch 4 when in use.
It is also connected with common return electrode cable 24 between the wireless chip 1 and driving chip 2, common return can be fed back
The electrical potential information of electrode is used for real-time monitoring.
It is also connected with consumption electrode cable 25 between the wireless chip 1 and driving chip 2, the electricity of consumption electrode can be fed back
Position information, is used for real-time monitoring.
The wireless chip 1 is also connected with coil 6, and one can be used in the present embodiment and receive to realize for the coil 6
Wireless power source and viewdata signal, can also be respectively adopted power coil and data antenna to realize, can specifically without limiting
It is selected as needed, the coil 6 is connected with rectification circuit 12 and current stabilization circuit, and the current stabilization circuit is connected to described graceful
Che Site encoder 14.
The forward data line 22 is also connected on the power module 16 in the driving chip 2, the power module 16
It is also connect with the Manchester decoder 17, other of wireless chip 1 and driving chip 2 normally realize function in the present invention
Component is same as the prior art, and details are not described herein again.
Embodiment 3
A kind of means of communication of above-mentioned resolution ratio retina prosthese, as shown in Figure 3, comprising the following steps:
S1: the wireless chip 1 receives the wireless power source and data-signal of external equipment transmission, passes through the rectification circuit
12 and stabilizing circuit 13 generate 3.5V DC power supply, and by Manchester encoder 14 coding generate 3.5V differential encoding number
According to being transferred to the driving chip 2 by the forward data line 22；
S2: the driving chip 2 generates the DC power supply of 3V and 1V using the square wave of 3.5V by power module 16, and leads to
It crosses Manchester decoder 17 and decodes initial data and system clock from the differential encoded data；
S3: after the reverse data coding that the driving chip 2 also generates reverse data encoder 18, by reverse data
Line 23 is sent to the wireless chip 1, and is sent to the external equipment after being decoded by reverse data decoder 15.
Preferably, the differential encoded data is the data using Differential Manchester Encoding, while being compiled from Manchester
It is easy to recover initial data and clock in code, due to the characteristic of Manchester's code, charge accumulated will not be generated on conducting wire, from
And irreversible damage will not be caused to tissue in the case where wire insulation breakage.
Preferably, the reverse data is the data encoded using positive negative pulse stuffing, i.e., data rising edge is by a positive pulse
It indicates, failing edge is indicated by a negative pulse；The coding method is equally charge balance, simpler than Manchester's code,
And it is easy to decode.
Taking the above-mentioned ideal embodiment according to the present invention as inspiration, through the above description, relevant staff is complete
Various changes and amendments can be carried out without departing from the scope of the technological thought of the present invention' entirely.The technology of this invention
Property range is not limited to the contents of the specification, it is necessary to which the technical scope thereof is determined according to the scope of the claim.
Claims (5)
1. a kind of ultrahigh resolution retina prosthese, including microelectrode matrix, which is characterized in that the microelectrode matrix is assemblied in
On driving chip, the electrode of the microelectrode matrix is connected respectively to the channel on the driving chip, and the driving chip is logical
Excessive root connecting line is connected to wireless chip, and the driving chip and microelectrode matrix are implanted into retina anteposition or bottom together,
The wireless chip is placed on the outside of sclera；The wireless chip includes Manchester encoder and reverse data decoder, described
Driving chip includes Manchester decoder and reverse data encoder, and the Manchester encoder is connected by forward data line
It is connected to the Manchester decoder, the reverse data encoder is connected to the reverse data by reverse data line and decodes
Device；The forward data line includes two data lines, and the reverse data line is a data wire, and driving chip uses fine
Deep submicron process is made.
2. ultrahigh resolution retina prosthese as described in claim 1, which is characterized in that the wireless chip and driving chip
Between be also connected with common return electrode cable, consumption electrode cable is also connected between the wireless chip and driving chip.
3. ultrahigh resolution retina prosthese as claimed in claim 2, which is characterized in that the forward data line, reversed number
It all uses according to line, common return electrode cable and consumption electrode cable and is wound in the platinum for being enclosed with silica gel on the outside of helical structure
Line.
4. ultrahigh resolution retina prosthese as described in claim 1, which is characterized in that the wireless chip further includes rectification
Circuit and current stabilization circuit, the rectification circuit are connected to coil, and the current stabilization circuit is connected to the Manchester encoder.
5. ultrahigh resolution retina prosthese as described in claim 1, which is characterized in that the forward data line is also connected to
On power module in the driving chip, the power module is also connect with the Manchester decoder.
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| CN107115176A (en) * | 2017-05-22 | 2017-09-01 | 中国科学院苏州生物医学工程技术研究所 | A kind of vision repair system |
| WO2019014849A1 (en) * | 2017-07-18 | 2019-01-24 | 辛特科技有限公司 | Method for collecting and processing artificial eye image |
| CN111182863B (en) * | 2017-07-18 | 2022-01-04 | 辛特科技有限公司 | System for acquiring and processing artificial eye image |
| CN107519575A (en) * | 2017-09-26 | 2017-12-29 | 杭州暖芯迦电子科技有限公司 | A kind of retina prosthese |
| CN109925092A (en) * | 2017-12-18 | 2019-06-25 | 深圳先进技术研究院 | The artificial retina implant of silica gel packaging |
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| US6427087B1 (en) * | 2000-05-04 | 2002-07-30 | Optobionics Corporation | Artificial retina device with stimulating and ground return electrodes disposed on opposite sides of the neuroretina and method of attachment |
| US7211103B2 (en) * | 2002-04-11 | 2007-05-01 | Second Sight Medical Products, Inc. | Biocompatible bonding method and electronics package suitable for implantation |
| JP4958898B2 (en) * | 2005-04-28 | 2012-06-20 | セカンド サイト メディカル プロダクツ インコーポレイテッド | Implantable neurostimulator package |
| GB0612242D0 (en) * | 2006-06-21 | 2006-08-02 | Imp Innovations Ltd | Retinal prosthetic devices |
| CN100534404C (en) * | 2007-01-18 | 2009-09-02 | 上海交通大学 | Artificial retina neural flexible microelectrode array chips and processing method thereof |
| CN101058004A (en) * | 2007-05-28 | 2007-10-24 | 重庆大学 | Visual cortex nerve stimulating device and stimulating method |
| CN101791259A (en) * | 2010-01-07 | 2010-08-04 | 北京大学深圳研究生院 | Design of high-density microelectrode array outer-layer artificial retina front-end system |
| IT1403793B1 (en) * | 2010-12-30 | 2013-10-31 | St Microelectronics Srl | RETINAL PROSTHESIS |
| CN203693899U (en) * | 2013-12-26 | 2014-07-09 | 中国人民解放军第二军医大学 | Bio-energy electronic retina |
| CN205144796U (en) * | 2015-10-26 | 2016-04-13 | 杭州暖芯迦电子科技有限公司 | Ultrahigh resolution retina false body |
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