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CN105125838A - Traditional Chinese medicine composite for treating infantile asthma and preparing method thereof - Google Patents

Traditional Chinese medicine composite for treating infantile asthma and preparing method thereof Download PDF

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Publication number
CN105125838A
CN105125838A CN201510651409.4A CN201510651409A CN105125838A CN 105125838 A CN105125838 A CN 105125838A CN 201510651409 A CN201510651409 A CN 201510651409A CN 105125838 A CN105125838 A CN 105125838A
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parts
chinese medicine
medicine composition
asthma
radix
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张娜
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Linyi Caozhimei Pharmaceutical Technology Co Ltd
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Linyi Caozhimei Pharmaceutical Technology Co Ltd
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Priority to CN201510651409.4A priority Critical patent/CN105125838A/en
Priority to CN201610320907.5A priority patent/CN105963501A/en
Publication of CN105125838A publication Critical patent/CN105125838A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605Morus (mulberry)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/076Poria
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/27Asclepiadaceae (Milkweed family), e.g. hoya
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    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/535Perilla (beefsteak plant)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/57Magnoliaceae (Magnolia family)
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/79Schisandraceae (Schisandra family)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
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Abstract

The invention relates to a traditional Chinese medicine composite for treating infantile asthma and a preparing method thereof and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine composite is prepared from folium mori, folia perillae acutae, schisandra chinensis, almonds, dried tangerine or orange peels, poria cocos, tendril-leaved fritillary bulbs, marsdenia longipes, rhizoma arisasmatis and liquorice. The traditional Chinese medicine composite can induce perspiration to dispel cold, free lung and relieve asthma, expel phlegm to arrest coughing, sooth liver and relieve stagnant Qi, and clear heat and moisten lung and has the advantages that preparing technology is simple, curative effect is good, side effect is light, taking is convenient, and application and popularization are easy.

Description

A kind of Chinese medicine composition for the treatment of infantile asthma and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of infantile asthma and preparation method thereof, belong to technical field of Chinese medicines.
Background technology
The commonly encountered diseases childhood period that infantile asthma being and frequently-occurring disease are the chronic ill reactive disorders of air flue participated in by the inflammation cells such as eosinophilic granulocyte, mastocyte and T lymphocyte and cytokine.Mostly because of physical weakness, or touch following factor and have the infant of latent phlegm to bring out primary disease to lung: meet sense wind and cold, direct stimulation is depressed, or environment cataclysm, sucks dust and diet etc.Because development in children is not yet ripe, premunition is low, and belong to the body of immature yin and yang, its internal organs are tender and lovely, and shape gas does not fill, and how empty lung spleen is, and easily empty easily real, and with the passing of time phlegm stagnancy is easy to heat-transformation, mostly is intermingling cold and heat, deficiency and excess depositing in clinical manifestation.Children's's internal organs grow also immaturity.Because human body skin belongs to lung to be responsible for, lungs are tender and lovely, and it is poor that skin defends outer function, skin space between skin and muscles is not fine and close, and wind and cold, wind heat invade human body by fur or mouth and nose, suffer from a deficiency of the kidney, spleen, lung, the dirty functional disorder of kidney three cause phlegm retention to be formed, and pathogen is taken advantage of a weak point, and pathogen enters lung meridian priming latent phlegm, phlegm rising following QI, obstruction of QI due to retention of phlegm, fights mutually sharp, obstructing airway, ascending or descending movement of vital Qi is unfavorable, so that the lacking of many suctions of breathing out, breath dyspnea with rapid and short breath, throat croup expectorant toot.Symptom is: rapid breathing, and suddenly, uncomfortable in chest rough, larynx has asked wheezing sound in outbreak, must not pant put down sleeping.The general outbreak in paroxysmal, or occur agitation, perspiration, expectoration, livid purple, pale complexion, weigh the then symptom such as obnubilation.
Current infantile asthma has western medicine method and treatment by Chinese herbs method.Quick-acting cushion can make asthma attack symptom stop.These act on medicine rapidly can eliminate tracheospasm, contributes to breathing.The medicines such as albuterol (being also salbutamol) can be used by nebulizer or metered-dose inhaler.Some controlling medicines also show effect for prevention of asthma.Inhaled steroid is exactly one of them, and energy dephlogistication and swelling, avoid baby to pant.Above-mentioned Western medicine in a short time can effective Control of asthma, but life-time service easily produces drug resistance, even the state of an illness may be increased the weight of, how Control of asthma, China and even a challenge facing of the whole world are become, and Chinese medicine have action temperature and, onset is lasting and from the feature of basic treatment asthma, become the research and development viewpoint that current asthma medications is new.
Chinese patent application 201310440498.9 discloses a kind of pharmaceutical composition for the treatment of infantile asthma, this pharmaceutical composition comprises following raw materials: Herba Artemisiae Scopariae, Fructus Gardeniae, Radix Sophorae Flavescentis, Bulbus Fritillariae Thunbergii, Radix Glycyrrhizae, Radix Et Rhizoma Rhei, Flos Matricariae chamomillae, this pharmaceutical composition plays certain clearing away heat-damp and promoting diuresis, the effect of preventing phlegm from forming and stopping coughing, but at diaphoresis cold expelling, depressed lung-energy dispersing aspect effect is not very remarkable.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition for the treatment of infantile asthma, this Chinese medicine composition has diaphoresis cold expelling, depressed lung-energy dispersing, expelling phlegm for arresting cough, effect of soothing the liver dispelling the stagnated QI and clearing heat and moistening lung, also have that preparation technology is simple, good effect, side effect be low, taking convenience and be easy to advantages such as applying, in addition, the present invention also provides corresponding manufacturing process to be made under the prerequisite ensureing curative effect by this pharmaceutical composition to facilitate easy-to-use preparation.
Chinese medicine composition of the present invention is prepared from by the raw material of following parts by weight: Folium Mori 10-20 part, Folium Perillae 5-10 part, Fructus Schisandrae Chinensis 1-6 part, Semen Armeniacae Amarum 3-10 part, Pericarpium Citri Reticulatae 2-9 part, Poria 9-15 part, Bulbus Fritillariae Cirrhosae 3-9 part, Radix Marsdeniae Longipedis 6-15 part, Rhizoma Arisaematis 3-9 part and Radix Glycyrrhizae 1-10 part.
Further, described Chinese medicine composition is prepared from by the raw material of following parts by weight: 10 parts, Folium Mori, Folium Perillae 5 parts, Fructus Schisandrae Chinensis 6 parts, 5 parts, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae 9 parts, 9 parts, Poria, Bulbus Fritillariae Cirrhosae 6 parts, Radix Marsdeniae Longipedis 10 parts, Rhizoma Arisaematis 6 parts and 5 parts, Radix Glycyrrhizae.
Further, described Chinese medicine composition is prepared from by the raw material of following parts by weight: 20 parts, Folium Mori, Folium Perillae 10 parts, Fructus Schisandrae Chinensis 2 parts, 10 parts, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae 2 parts, 15 parts, Poria, Bulbus Fritillariae Cirrhosae 3 parts, Radix Marsdeniae Longipedis 15 parts, Rhizoma Arisaematis 9 parts and 10 parts, Radix Glycyrrhizae.
Further, described Chinese medicine composition is prepared from by the raw material of following parts by weight: 15 parts, Folium Mori, Folium Perillae 8 parts, Fructus Schisandrae Chinensis 4 parts, 8 parts, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae 6 parts, 12 parts, Poria, Bulbus Fritillariae Cirrhosae 9 parts, Radix Marsdeniae Longipedis 6 parts, Rhizoma Arisaematis 3 parts and 2 parts, Radix Glycyrrhizae.
Further, described Chinese medicine composition is made into capsule, granule, tablet or pill.
Accordingly, the preparation method of described Chinese medicine composition comprises the steps:
A) take Folium Mori, pulverize, cross 40-60 mesh sieve, obtain coarse powder, coarse powder is sucked air-stream type ultrafine pulverizer and carry out micronizing, pulverize pressure 0.5MPa, charging rate is 30mg/s, carries out micronizing after drying, crosses 800 mesh sieves, obtains Ultra-fine Powder of Mulberry Leaves;
B) Folium Perillae, Fructus Schisandrae Chinensis, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae, Poria, Bulbus Fritillariae Cirrhosae, Radix Marsdeniae Longipedis, Rhizoma Arisaematis and Radix Glycyrrhizae is taken, pulverize, add the alcoholic solution of the 4-8 60-90% volumn concentration doubly of medical material gross weight, decoct 2-3 time, each 2-5 hour, filter, obtain and merging filtrate, at 50-60 DEG C, be evaporated to the extractum that relative density is 1.20-1.35;
C) by described Ultra-fine Powder of Mulberry Leaves and the mixing of described extractum, dry, pulverize powdered, cross 200 mesh sieves, obtain Chinese medicine composition of the present invention.
Source, the nature and flavor of the present invention's component used, return through and effect:
Folium Mori: loose wind heat and let out lung-heat, to affection due to external wind and heat, headache, cough etc., the fit applications such as normal and Flos Chrysanthemi, Flos Lonicerae, Herba Menthae, Radix Peucedani, Radix Platycodonis.Folium Mori not only can be used for the conjunctival congestion photophobia that wind heat causes, and can clearing away liver-fire, to the conjunctival congestion and swelling pain of flaming up of liver-fire, can with the fit applications such as Flos Chrysanthemi, Semen Cassiae, Semen Plantaginis.
Folium Perillae: be the dried leaves of labiate Folium Perillae; Acrid in the mouth, warm in nature; Return lung, spleen channel; Induce sweat cold expelling, relieving QI stagnancy in the stomach.
Fructus Schisandrae Chinensis: this product is the dry mature fruit of magnoliaceae schisandra; Sour in the mouth, sweet, warm in nature; Return lung, the heart, kidney channel; Restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.
Semen Armeniacae Amarum: this product is the dry seed of the bitter in the mouth such as rosaceous plant Fructus Pruni or Prunus armeniaca L.var.ansu Maxim.; Bitter in the mouth, warm in nature; Enter lung, large intestine channel; Expelling phlegm for arresting cough, relievings asthma, intestine moistening.
Pericarpium Citri Reticulatae: be the dry peel of rutaceae orange, bitter in the mouth, pungent, warm in nature; Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.
Poria: this product is the dry sclerotia of On Polyporaceae Poria; Sweet in the mouth, light, property is put down; GUIXIN, lung, spleen, kidney channel; Promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.
Bulbus Fritillariae Cirrhosae: this product is the dry bulb of liliaceous plant Bulbus Fritillariae Cirrhosae; Bitter in the mouth, sweet, cold nature; Return lung, heart channel; Clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.
Radix Marsdeniae Longipedis: this product is that asclepiadaceae Marsdenia plant Radix Marsdeniae Longipedis is used as medicine with root or Herb; Sweet in the mouth, micro-hardship, puckery, warm in nature; Promoting blood circulation and hemostasis, relieving cough and asthma.
Rhizoma Arisaematis: this product is the dry tuber of aroid Rhizoma Arisaematis; Bitter in the mouth, pungent, warm in nature; Return lung, liver, spleen channel; Drying dampness to eliminate phlegm, expellings wind and relieving convulsion, mass dissipating and swelling eliminating.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L.; Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Compared with prior art, the present invention has following technical advantage:
1, Chinese medicine composition of the present invention is compared with the common drug of existing other treatment infantile asthma, and at diaphoresis cold expelling, depressed lung-energy dispersing, expelling phlegm for arresting cough, the aspects such as soothing the liver dispelling the stagnated QI and clearing heat and moistening lung have more remarkable efficacy.
2, compared with the chemicals of Current therapeutic infantile asthma, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, and untoward reaction and side effect significantly reduce, and Chinese medicine composition effect of the present invention is comprehensive, medication effect is better, efficiently solves the morbidity root of infantile asthma.
3, Chinese medicine composition of the present invention also has that compatibility science, preparation technology are simple, good effect, side effect are low, taking convenience and be easy to advantages such as applying.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.
embodiment 1
The embodiment of the present invention 1 Chinese medicine composition is prepared from by the raw material of following parts by weight: 10 parts, Folium Mori, Folium Perillae 5 parts, Fructus Schisandrae Chinensis 6 parts, 5 parts, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae 9 parts, 9 parts, Poria, Bulbus Fritillariae Cirrhosae 6 parts, Radix Marsdeniae Longipedis 10 parts, Rhizoma Arisaematis 6 parts and 5 parts, Radix Glycyrrhizae.
Preparation method is as follows: take Folium Mori, pulverizes, and crosses 60 mesh sieves, obtains coarse powder, coarse powder is sucked air-stream type ultrafine pulverizer and carry out micronizing, and pulverize pressure 0.5MPa, charging rate is 30mg/s, carries out micronizing after drying, crosses 800 mesh sieves, obtains Ultra-fine Powder of Mulberry Leaves; Take Folium Perillae, Fructus Schisandrae Chinensis, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae, Poria, Bulbus Fritillariae Cirrhosae, Radix Marsdeniae Longipedis, Rhizoma Arisaematis and Radix Glycyrrhizae, pulverize, add the alcoholic solution of 75% volumn concentration of 6 times of medical material gross weight, decoct 2 times, each 4 hours, filter, obtain and merging filtrate, at 50 DEG C, be evaporated to the extractum that relative density is 1.25; By described Ultra-fine Powder of Mulberry Leaves and the mixing of described extractum, dry, pulverize powdered, cross 200 mesh sieves, obtain the embodiment of the present invention 1 Chinese medicine composition, add the adjuvant for the preparation of capsule preparations, incapsulate in shell, obtain the capsule of the embodiment of the present invention 1 Chinese medicine composition.
embodiment 2
The embodiment of the present invention 2 Chinese medicine composition is prepared from by the raw material of following parts by weight: 20 parts, Folium Mori, Folium Perillae 10 parts, Fructus Schisandrae Chinensis 2 parts, 10 parts, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae 2 parts, 15 parts, Poria, Bulbus Fritillariae Cirrhosae 3 parts, Radix Marsdeniae Longipedis 15 parts, Rhizoma Arisaematis 9 parts and 10 parts, Radix Glycyrrhizae.
Preparation method is as follows: take Folium Mori, pulverizes, and crosses 60 mesh sieves, obtains coarse powder, coarse powder is sucked air-stream type ultrafine pulverizer and carry out micronizing, and pulverize pressure 0.5MPa, charging rate is 30mg/s, carries out micronizing after drying, crosses 800 mesh sieves, obtains Ultra-fine Powder of Mulberry Leaves; Take Folium Perillae, Fructus Schisandrae Chinensis, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae, Poria, Bulbus Fritillariae Cirrhosae, Radix Marsdeniae Longipedis, Rhizoma Arisaematis and Radix Glycyrrhizae, pulverize, add the alcoholic solution of 75% volumn concentration of 4 times of medical material gross weight, decoct 2 times, each 4 hours, filter, obtain and merging filtrate, at 50 DEG C, be evaporated to the extractum that relative density is 1.35; By described Ultra-fine Powder of Mulberry Leaves and the mixing of described extractum, dry, pulverize powdered, cross 200 mesh sieves, obtain the embodiment of the present invention 2 Chinese medicine composition, add the adjuvant for the preparation of capsule preparations, incapsulate in shell, obtain the capsule of the embodiment of the present invention 2 Chinese medicine composition.
embodiment 3
The embodiment of the present invention 3 Chinese medicine composition is prepared from by the raw material of following parts by weight: 15 parts, Folium Mori, Folium Perillae 8 parts, Fructus Schisandrae Chinensis 4 parts, 8 parts, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae 6 parts, 12 parts, Poria, Bulbus Fritillariae Cirrhosae 9 parts, Radix Marsdeniae Longipedis 6 parts, Rhizoma Arisaematis 3 parts and 2 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
clinical observation on the therapeutic effect
1, case selection: in 300 routine infantile asthma clinical patients volunteers, boy patient 150 example, young girl patient 150 example, age bracket be 3-10 year, all patients all has typical symptoms of asthma, and in sex, age, the course of disease no difference of science of statistics.
2, diagnostic criteria:
(1) tcm diagnosis standard: formulate according to " TCM syndrome diagnostic criteria " content relevant in " Chinese medical disease Standardization of diagnosis and curative effect ", " new Chinese medicine clinical guidance principle " (2002) and " the senior book series Pediatrics of Chinese Medicine of Chinese medicine " (second edition) " asthma " that State Administration of Traditional Chinese Medicine issues:
Primary symptom: cough with asthma is out of breath, wheezing in larynx, expectoration thickness.
Secondary disease: heating, nausea and vomiting, poor appetite, abdominal distention, constipation or sticky, yellowish or reddish urine.
Tongue fur pulse condition: red tongue, thick and greasy fur, slippery and rapid pulse, or fingerprint is purple.
In above-mentioned standard, need possess main symptom 2, secondary card more than 2, tongue fur is indispensable, and diagnosable is damp and hot asthma.
(2) Western medicine diagnose standard: " children with asthma diagnosis and treatment guide " according to the revision in 2008 of department of pediatrics branch of Chinese Medical Association pneumatology group:
1. recurrent exerbation pant, cough, tachypnea, uncomfortable in chest, many with contact allergen, cold air, physics, chemical irritation, respiratory tract infection and motion etc. relevant, be everlasting night and (or) early morning show effect or aggravate;
2. during outbreak at two lung audible and be dispersed in or diffusivity, the wheezing sound based on expiratory phase, expiratory phase prolongation;
3. above-mentioned symptom and the sign effective or spontaneous remission through asthma treatment;
Panting 4. caused by other diseases, cough, tachypnea and breast vexed;
5. its atypical clinical manifestations person's (as without obviously panting or wheezing sound), at least should possess following 1: A, brinchial provocation test or motion activated test positive; B, alleged occurrence reversible airflow limitation; C, maximal expiratory flow (PEF) aberration rate every day (continuously monitoring 1-2 week) are higher than 20%.Meet 1.-4. article or 4., 5. article person, can asthma be diagnosed as.
3, exclusion standard: 1. do not meet diagnostic criteria and inclusive criteria person; 2. the serious heart, liver, kidney, lung disease or congenital diseases are had; 3. severity is the children with bronchial asthma disease of severe and the person that occurs severe attack after including in; 4. to institute medicine allergy sufferers.
4, efficacy assessment standard: according to " new Chinese medicine guideline of clinical investigations ":
Clinic control: symptoms of asthma complete incidence graph, even if there is mild episode not need medication to alleviate once in a while;
Effective: obviously to alleviate before asthma attack comparatively, still need with glucocorticoid or bronchodilator;
Take a turn for the better: symptoms of asthma alleviates to some extent, still needs with glucocorticoid or bronchodilator;
Invalid: clinical symptoms is without improvement or increase the weight of on the contrary;
Total effective rate=(clinic control+effective+improvement)/total number of cases × 100%.
5, instructions of taking: 300 patient volunteers are divided into 3 groups at random, often organize 100 people, is respectively treatment A group, treatment B group and matched group, treatment A group, treatment B component do not take the capsule preparations that the embodiment of the present invention 1,3 prepares, every day 3 times, each 1-2g, serve on 1 month.Matched group takes salbutamol sheet (Shanxi Yun Peng pharmaceutical Co. Ltd, the accurate word H34022402 of traditional Chinese medicines), and each 1-2 sheet, 3 times on the one, serve on 1 month.
6, therapeutic outcome: as shown in table 1.
Table 1 therapeutic outcome
This test adopts salbutamol sheet as a control group, by comparing with the therapeutic effect of Chinese medicine composition of the present invention, can find out the curative effect of traditional Chinese medicine composition for treating infantile asthma of the present invention.The clinic control rate of Chinese medicine composition of the present invention reaches more than 70%, and total effective rate reaches more than 90%, higher than clinic control rate and the total effective rate of matched group, wherein best with the therapeutic effect for the treatment of B group.Visible, the good effect of Chinese medicine composition of the present invention, clinic control rate is high, can be used as the drug use for the treatment of infantile asthma.
Owing to describing the present invention by above preferred embodiment, in spirit of the present invention and/or scope, any for replacement/of the present invention or combination implement the present invention, be all apparent for a person skilled in the art, and be included among the present invention.

Claims (6)

1. treat the Chinese medicine composition of infantile asthma for one kind, it is characterized in that, be prepared from by the raw material of following parts by weight: Folium Mori 10-20 part, Folium Perillae 5-10 part, Fructus Schisandrae Chinensis 1-6 part, Semen Armeniacae Amarum 3-10 part, Pericarpium Citri Reticulatae 2-9 part, Poria 9-15 part, Bulbus Fritillariae Cirrhosae 3-9 part, Radix Marsdeniae Longipedis 6-15 part, Rhizoma Arisaematis 3-9 part and Radix Glycyrrhizae 1-10 part.
2. the Chinese medicine composition for the treatment of infantile asthma as claimed in claim 1, it is characterized in that, be prepared from by the raw material of following parts by weight: 10 parts, Folium Mori, Folium Perillae 5 parts, Fructus Schisandrae Chinensis 6 parts, 5 parts, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae 9 parts, 9 parts, Poria, Bulbus Fritillariae Cirrhosae 6 parts, Radix Marsdeniae Longipedis 10 parts, Rhizoma Arisaematis 6 parts and 5 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of infantile asthma as claimed in claim 1, it is characterized in that, be prepared from by the raw material of following parts by weight: 20 parts, Folium Mori, Folium Perillae 10 parts, Fructus Schisandrae Chinensis 2 parts, 10 parts, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae 2 parts, 15 parts, Poria, Bulbus Fritillariae Cirrhosae 3 parts, Radix Marsdeniae Longipedis 15 parts, Rhizoma Arisaematis 9 parts and 10 parts, Radix Glycyrrhizae.
4. the Chinese medicine composition for the treatment of infantile asthma as claimed in claim 1, it is characterized in that, be prepared from by the raw material of following parts by weight: 15 parts, Folium Mori, Folium Perillae 8 parts, Fructus Schisandrae Chinensis 4 parts, 8 parts, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae 6 parts, 12 parts, Poria, Bulbus Fritillariae Cirrhosae 9 parts, Radix Marsdeniae Longipedis 6 parts, Rhizoma Arisaematis 3 parts and 2 parts, Radix Glycyrrhizae.
5. the Chinese medicine composition of the treatment infantile asthma as described in as arbitrary in claim 1-4, is characterized in that: described Chinese medicine composition is made into capsule, granule, tablet or pill.
6. prepare as arbitrary in claim 1-4 as described in the method for Chinese medicine composition for the treatment of infantile asthma, it is characterized in that comprising the steps:
A) take Folium Mori, pulverize, cross 40-60 mesh sieve, obtain coarse powder, coarse powder is sucked air-stream type ultrafine pulverizer and carry out micronizing, pulverize pressure 0.5MPa, charging rate is 30mg/s, carries out micronizing after drying, crosses 800 mesh sieves, obtains Ultra-fine Powder of Mulberry Leaves;
B) Folium Perillae, Fructus Schisandrae Chinensis, Semen Armeniacae Amarum, Pericarpium Citri Reticulatae, Poria, Bulbus Fritillariae Cirrhosae, Radix Marsdeniae Longipedis, Rhizoma Arisaematis and Radix Glycyrrhizae is taken, pulverize, add the alcoholic solution of the 4-8 60-90% volumn concentration doubly of medical material gross weight, decoct 2-3 time, each 2-5 hour, filter, obtain and merging filtrate, at 50-60 DEG C, be evaporated to the extractum that relative density is 1.20-1.35;
C) by described Ultra-fine Powder of Mulberry Leaves and the mixing of described extractum, dry, pulverize powdered, cross 200 mesh sieves, obtain Chinese medicine composition of the present invention.
CN201510651409.4A 2015-10-10 2015-10-10 Traditional Chinese medicine composite for treating infantile asthma and preparing method thereof Withdrawn CN105125838A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107375645A (en) * 2017-07-05 2017-11-24 庞世斌 A kind of Chinese medicine composition for treating asthma

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107348287A (en) * 2017-08-23 2017-11-17 宁波甬鸿优尚餐饮有限公司 A kind of relieving cough and reducing sputum Radix Codonopsis rhizoma atractylodis Chinese herbal health-caring beverage and preparation method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1337240A (en) * 2000-08-04 2002-02-27 王晓华 Chinese medicine for treating children's bronchial asthma
CN101439144A (en) * 2007-11-20 2009-05-27 马东君 Chinese medicine composing prescription for treating children's bronchial asthma
CN103463399A (en) * 2013-09-25 2013-12-25 李燕宁 Medicament for treating infantile asthma and preparation method thereof
CN104288477A (en) * 2014-10-29 2015-01-21 王丽丽 Traditional Chinese medicine preparation curing infantile asthma
CN104940485A (en) * 2015-07-27 2015-09-30 青岛蓝盛洋医药生物科技有限责任公司 Traditional Chinese medicine composition for treating infantile asthma and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1337240A (en) * 2000-08-04 2002-02-27 王晓华 Chinese medicine for treating children's bronchial asthma
CN101439144A (en) * 2007-11-20 2009-05-27 马东君 Chinese medicine composing prescription for treating children's bronchial asthma
CN103463399A (en) * 2013-09-25 2013-12-25 李燕宁 Medicament for treating infantile asthma and preparation method thereof
CN104288477A (en) * 2014-10-29 2015-01-21 王丽丽 Traditional Chinese medicine preparation curing infantile asthma
CN104940485A (en) * 2015-07-27 2015-09-30 青岛蓝盛洋医药生物科技有限责任公司 Traditional Chinese medicine composition for treating infantile asthma and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107375645A (en) * 2017-07-05 2017-11-24 庞世斌 A kind of Chinese medicine composition for treating asthma

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Application publication date: 20151209