CN105031782B - Method for improving dosing quantity metering accuracy of powder inhalation dosing device - Google Patents
Method for improving dosing quantity metering accuracy of powder inhalation dosing device Download PDFInfo
- Publication number
- CN105031782B CN105031782B CN201510374266.7A CN201510374266A CN105031782B CN 105031782 B CN105031782 B CN 105031782B CN 201510374266 A CN201510374266 A CN 201510374266A CN 105031782 B CN105031782 B CN 105031782B
- Authority
- CN
- China
- Prior art keywords
- vibration
- powder
- medicine
- dosing
- vibrating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Landscapes
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicinal Preparation (AREA)
Abstract
A method for improving the dosing quantity metering accuracy of a powder inhalation dosing device belongs to the field of inhalation dosing instruments. It adopts vibration gear to carry out whole knock-on vibration through the carousel to component under the runner, simultaneously, still is provided with the second vibrating part-interior cartridge that can freely vibrate in step in powder storage container, carries out compound vibration to the powder in the powder storage container, through adopting main, from vibrating part's structure, produces dual vibration effect, makes the medicine powder that is arranged in powder storage container, can more even inflow quantitative medicine inslot, can ensure better the measurement accuracy of powder aerosol dosing device powder storage container single dose powder dosage that supplies in the process of dosing at every turn has increased the powder aerosol dosing device to the good adaptability of wider range powder medicament kind. Can be widely applied to the design and manufacture fields of powder aerosol administration devices with various specifications.
Description
Technical Field
The invention belongs to the field of devices for inputting media into human bodies, and particularly relates to an inhalation type drug delivery device for delivering specified dose of aerosol powder into the lungs of patients through oral cavities along with respiratory airflow.
Background
In modern medical technology, the medicine can directly enter the lung and be absorbed into the blood by oral or nasal inhalation, so that the first-pass effect of the liver is avoided.
Clinically, pulmonary administration is mainly used for treating pulmonary diseases such as asthma, chronic obstructive pneumonia, cystic fibrosis and the like. Due to the characteristics of thin alveolar epithelial cell wall, large surface area, low enzyme metabolic activity and the like, in recent years, a pulmonary administration mode gradually becomes a new way for non-invasive administration of more drugs (such as polypeptide drugs, protein drugs and the like).
In the pulmonary administration mode, the powder aerosol has many advantages compared with the aerosol, such as the problem that the aerosol is matched with a device by a patient in the using process can be avoided, and a propellant is not needed, so that the powder aerosol is the pulmonary inhalation preparation form with the most application prospect at present.
An aerosol refers to a formulation of micronized drug or drug in capsules, vesicles or multi-dose reservoirs with carriers, which is actively inhaled by the patient into the lungs using a specially designed aerosol delivery device or inhalation device (also known as an inhalation delivery device, and also known as a dry powder inhalation device or a dry powder delivery device). The inhalation powder inhalation depends on the autonomous respiration of a patient to enable the medicine powder to enter a respiratory system, and has the characteristics of convenience in carrying, low cost and strong stability. In recent years, the application range of the inhalation aerosol powder has been expanded from the traditional lung local disease therapeutic drug to the systemic administration of polypeptide proteins, antibiotics, biological drugs and cardiovascular system drugs. Especially, some biological macromolecules can achieve ideal bioavailability after inhalation-pulmonary administration of the medicine powder.
The powder aerosol drug delivery device is the core of powder aerosol development, and the quality of the design of the powder aerosol drug delivery device directly influences the lung deposition efficiency of the powder aerosol.
For dry powder aerosol drug delivery devices, there are generally two general categories: single doses and multiple doses, with multiple doses generally being subdivided into blister and reservoir types.
Reservoir-type inhalation drug delivery devices are usually provided with a powder container and a corresponding metering member by means of which the powdered medicament is dispensed from the powder container in successive doses.
One significant problem with the micron-sized powders of powder aerosol delivery devices is that they have poor flow characteristics and the powder particles have a large surface energy and tend to form "clumps" which can present significant difficulties in metering each dose of depot drug.
The applicant previously filed a chinese patent invention with an announcement date of 2015, 2, 18 and an announcement number of CN102218182B, which discloses a vibrating drug delivery device for a dry powder drug delivery device, comprising a housing, a powder storage container, a drug delivery metering assembly and a flow channel member, wherein the flow channel member is sequentially connected with a gas inlet, the drug delivery metering assembly and a suction nozzle; the invention is characterized in that an inverted cone-shaped medicine powder storage container is arranged at the upper part of a shell, a dosing metering component comprising a central rotating shaft and a quantitative medicine feeding disc is arranged below the inverted cone-shaped medicine powder storage container, a raised vibrating tooth is arranged at the outlet of the inverted cone-shaped medicine powder storage container, and a circle of raised teeth are arranged at the vertical height position of the central rotating shaft corresponding to the vibrating tooth; the vibrating teeth are matched with the raised teeth to form a vibrating component which can make the outlet of the inverted cone-shaped medicine powder storage container vibrate. Because the vibration mode of the vibration teeth-the convex teeth is adopted, the vibration dosing unit is arranged at the outlet of the powder storage (namely the inverted cone-shaped medicinal powder storage container), the magnitude of the vibration force or the vibration amplitude is irrelevant to the elastic component and is not influenced by the change of the medicinal powder storage capacity, the function of accurately metering the medicinal powder dose is realized, and the risk of over-metering dosing is avoided.
In the above technical scheme, once the design parameter (the reverse taper angle) of the reverse taper powder storage container is determined, the reverse taper powder storage container can only adapt to the medicine powder within a certain flowability range, and cannot adapt to the medicine powder with worse flowability index parameters. When the physical performance index (usually referring to the fluidity index of the medicine powder) of the filled medicine powder is changed, the metering accuracy of the medicine powder dosage (namely commonly called single dosage) in each administration process can be ensured only by redesigning the mechanical design parameters of the inverted cone-shaped medicine powder storage container and the vibration administration unit, so that the designed and produced powder aerosol administration device can only aim at a specific medicine powder and does not have good medicine type adaptability and mechanical structure parameter design and adjustment convenience.
Disclosure of Invention
The technical problem to be solved by the invention is to provide a method for improving the dosing accuracy of a powder inhalation dosing device, which is characterized in that while the powder storage container of a powder storage unit is subjected to integral impact vibration, an inner medicine barrel which is a second vibration part and can synchronously and freely vibrate is also arranged in the powder storage container, and the medicine powder in the powder storage container is subjected to compound vibration, so that the dosing accuracy of the powder medicine amount supplied by the powder storage unit in each dosing process of the whole powder inhalation dosing device is better ensured, the workload of mechanical structure design change required by the change of the variety of the filled medicine powder medicine can be reduced, and the good adaptability of the powder inhalation dosing device to a wider range of powder medicine types is increased.
The technical scheme of the invention is as follows: the powder aerosol dosing device comprises a powder storage container and a dosing metering component which are arranged in a shell of the dosing device, wherein a suction nozzle is arranged on the outer side of the shell, a flow passage part is arranged in the shell, and the flow passage part is sequentially connected with an air inlet, the dosing metering component and the suction nozzle through an air path; the drug delivery device shell consists of an upper cover, a shell and a lower shell which are coaxially sleeved in sequence, and a spiral cover is arranged at the lower end of the lower shell; the runner component consists of an upper runner component and a lower runner component which are buckled into an integral structure to form a complete runner gas circuit; the method is characterized in that:
the medicine powder storage container at least comprises an outer medicine cylinder fixedly connected to the lower flow passage component;
the dosing metering component at least comprises a rotary disc, the upper end surface of the rotary disc is provided with a plurality of quantitative medicine grooves, and the quantitative medicine grooves are uniformly distributed along the circumference of the rotary disc; the quantitative medicine groove is of a blind hole structure;
the lower end of the outer cartridge is provided with a lower opening end penetrating through the lower flow passage component, and the lower opening end is positioned on the circumference of the upper end surface of the rotary table where a plurality of quantitative medicine grooves are distributed;
a vibration gear and a spring are sequentially coaxially sleeved below the turntable;
a circle of upper vibration teeth are arranged on the lower end surface of the turntable; a circle of lower vibration teeth are arranged on the upper end surface of the vibration gear; the tooth tips of the upper vibration teeth and the lower vibration teeth are oppositely arranged to form a one-way ratchet wheel rotation motion pair;
at least one pawl structure is arranged on the outer edge of the rotary disc, and the pawl structure consists of a pawl arm connected with the outer edge of the rotary disc and a pawl end part positioned at one end of the pawl arm;
at least one-way open slot is formed in the position, corresponding to the position of the rotary table, on the inner wall of the lower shell;
the end part of the pawl is positioned on the same horizontal plane with the one-way open slot;
the rotary cover, the spring, the vibration gear, the rotary disc and the outer medicine cylinder arranged on the lower component of the flow channel form a vibration medicine storage unit of the powder inhalation administration device;
the rotary cover is used for driving the dosing metering component and the vibration medicine storage unit to work, and the dosing metering function and the vibration function of the medicine storage unit are respectively realized;
the vibration gear provides a vibration source for the rotary disc and the medicine storage unit under the action of the spring;
the powder inhalation dosing device adopts upper and lower vibration teeth which are arranged oppositely, and realizes the vibration function of the medicine storage unit through a longitudinal vibration source which is provided for the turntable and the outer medicine barrel, so that the metering accuracy of the medicine powder amount supplied by the medicine storage unit in the dosing process of the whole powder inhalation dosing device is improved, and the whole dosing device has good medicine type adaptability and the convenience of the adjustment of the vibration effect of the mechanical structure parameter design.
When the rotary cover rotates to a first rotation angle along a first rotation direction, the rotary cover drives the vibration teeth to rotate, the rotary plate does not rotate under the limiting effect of the pawl structure arranged on the outer edge of the rotary plate, relative motion is generated between the vibration gear and the rotary plate, and because the upper vibration teeth and the lower vibration teeth are respectively arranged on the combined end surface of the vibration gear and the rotary plate, when the relative motion is generated between the vibration gear and the rotary plate, under the elastic action of the spring, mutual staggering is generated between the upper vibration teeth and the lower vibration teeth, so that the vibration gear continuously knocks the rotary plate to generate a longitudinal vibration effect, and the vibration effect is transmitted to an outer cartridge case on a component positioned below a flow channel through the rotary plate to generate a first heavy vibration effect.
Further, an inner medicine cylinder is arranged in the outer medicine cylinder, the inner medicine cylinder is nested in the outer medicine cylinder, and the inner medicine cylinder can freely move in the outer medicine cylinder; the inner cartridge is a hollow tubular structure, and the diameter of the lower end of the inner cartridge is smaller than that of the upper end of the inner cartridge; the longitudinal section structure of the inner medicine cylinder wall is an inverted isosceles trapezoid structure with a large upper part and a small lower part; the rotary cover, the spring, the vibration gear, the rotary disc and the inner and outer medicine barrels arranged on the lower component of the flow passage form a composite vibration medicine storage unit of the powder inhalation administration device; the vibration gear of the medicine bottle serves as a main vibration part, and the inner medicine cylinder serves as a secondary vibration part; the powder aerosol drug delivery device is characterized in that the vibration gear serves as a main vibration part to vibrate the powder storage container, the inner medicine barrel capable of synchronously and freely vibrating serves as a secondary vibration part in the powder storage container, and the powder aerosol drug powder filled in the outer medicine barrel is subjected to sufficient composite vibration through the free movement of the inner medicine barrel in the outer medicine barrel so as to further ensure the accuracy of the drug delivery quantity of the powder aerosol drug delivery device.
Furthermore, when the screw cap rotates to a first rotation angle along a first rotation direction to generate a first heavy vibration effect, the rotary disc can synchronously transmit the knocking vibration of the vibration gear to the inner medicine cylinder in the outer medicine cylinder to drive the inner medicine cylinder to freely vibrate in the outer medicine cylinder; the synchronous vibration of the inner cartridge case has a second vibration effect on the powder inhalation drug powder filled in the outer cartridge case, so that the drug powder in the drug powder storage container can flow into the quantitative drug groove more uniformly and stably, and the metering accuracy of the single dose of drug powder supplied by the drug powder storage container can be better ensured in each drug administration process of the powder inhalation drug administration device.
Specifically, the first rotation angle is 360 degrees per number of pawl structures.
Or, the first rotating angle is 360 degrees/the number of the one-way open slots.
The method for improving the dosing accuracy of the powder inhalation dosing device adjusts the strength of the whole vibration effect of the medicine storage unit by respectively changing the tooth number and the tooth height of the upper vibration tooth and the lower vibration tooth and the elasticity of the spring, and improves the dosing accuracy of the powder dosing of the medicinal powder.
According to the method for improving the dosing accuracy of the powder inhalation dosing device, the vibration gear is adopted, the component under the flow channel is subjected to integral knocking type vibration through the rotary table, a better integral vibration effect is generated, the requirement on the material strength of the vibration component is reduced, the design, the manufacture and the manufacturing cost of a product are favorably reduced, the good adaptability of the powder inhalation dosing device to a wider range of medicine powder types is improved, and the adverse effect on the dosing accuracy due to the poor flowability of powder inhalation powder is overcome.
Furthermore, the upper vibrating teeth are annularly and uniformly distributed on the lower end surface of the rotating disc by taking the rotating center of the rotating disc as the circle center; the lower vibrating teeth are annularly and uniformly distributed on the upper end surface of the vibrating gear by taking the rotating center of the vibrating gear as a circle center.
The first rotation direction is viewed as a counterclockwise rotation direction when viewed from the top of the powder inhalation delivery device.
Compared with the prior art, the invention has the advantages that:
1. the vibration gear is adopted below the medicine powder outlet of the medicine powder storage container, and the rotary disc is used for carrying out integral knocking type vibration on the component below the flow passage, so that a better vibration effect can be generated, the requirement on the material strength of the vibration component can be reduced, and the design, the manufacture and the manufacturing cost of a product can be favorably reduced;
2. through the adjustment of the elasticity of the spring, the tooth height of the vibration teeth and the mechanical structure parameters of the tooth number, the strength of the vibration force of the medicine powder storage container in the medicine feeding device can be conveniently changed, and the structure of the vibration assembly can be conveniently adjusted according to the fluidity index of the loaded medicine powder, so that the metering accuracy of the powder aerosol medicine feeding device can be better ensured, and the medicine feeding device has good convenience for adjusting the vibration effect and adaptability to the types of the medicine powder;
3. the main vibration component structure and the auxiliary vibration component structure are adopted to generate a dual vibration effect, so that the medicine powder in the medicine powder storage container can more uniformly flow into the quantitative medicine groove, and the metering accuracy of the dosage of the single dose of medicine powder supplied by the medicine powder storage container in each medicine feeding process of the powder inhalation medicine feeding device can be better ensured.
Drawings
FIG. 1 is a schematic top view of an exploded view of the relevant elements of the powder aerosol delivery device of the present invention;
FIG. 2 is a schematic bottom view of the relevant units of the powder aerosol delivery device of the present invention in an exploded configuration;
FIG. 3 is a schematic cross-sectional view of the inner and outer cartridges, the upper and lower flow channels and the turntable in the vibrating storage unit according to the present invention;
FIG. 4 is a schematic diagram of the assembly of the relevant units of the powder inhalation delivery device of the present invention;
fig. 5 is a schematic view of the position of the one-way open slot on the lower housing of the present invention.
In the figure, 1 is a lower shell, 1-1 is a one-way open slot, 3 is a rotary table, 3a is a quantitative medicine groove, 3b is an upper vibrating tooth, 3c is a pawl, 4 is an upper flow passage component, 5 is a lower flow passage component, 6 is a middle shell, 8 is a rotary cover, 12 is a vibrating gear, 12a is a lower vibrating tooth, 13 is a spring, 14 is an inner medicine cylinder, 14a is an outer medicine cylinder, 15 is a medicine cylinder cover, and 16 is an upper cover.
Detailed Description
The invention is further illustrated with reference to the following figures and examples.
As can be seen from fig. 1 to 4, the technical solution of the present invention provides a method for improving the dosing accuracy of a powder aerosol dosing device, wherein the powder aerosol dosing device comprises a powder storage container and a dosing metering assembly arranged in a housing of the dosing device, a suction nozzle is arranged outside the housing, a flow passage component is arranged inside the housing, and the flow passage component is sequentially connected with an air inlet, the dosing metering assembly and the suction nozzle through an air path; the drug delivery device shell consists of an upper cover, a shell and a lower shell which are coaxially sleeved in sequence, and a spiral cover is arranged at the lower end of the lower shell; the runner component consists of an upper runner component and a lower runner component which are buckled into an integral structure to form a complete runner gas circuit; the invention is characterized in that:
the shell is composed of an upper cover 16, a middle shell 6 and a lower shell 1, and a screw cover 8 (shown in figure 4) is sleeved on the lower shell.
The spiral cover is sequentially provided with a spring 13, a vibration gear 12 and a rotary disc 3, and the spring is sleeved on a central rotating shaft of the vibration gear (see figures 1 and 2).
On the upper end face of the vibration gear, a ring of raised lower vibration teeth 12a (see fig. 1) is provided; on the lower end face of the turntable, a ring of raised upper vibrating teeth 3b (see fig. 2) is provided.
A detent stop 3c (see fig. 2) is provided on the circumference of the turntable.
The upper end face of the rotary table is provided with a plurality of quantitative medicine grooves 3a which are uniformly distributed along the circumference of the rotary table by taking the central shaft of the rotary table as the circle center.
And a lower runner component 5 and an upper runner component 4 are arranged above the turntable, and the lower runner component and the upper runner component are buckled and fixedly connected into a whole to form a complete runner gas circuit.
In the technical scheme, the medicine powder storage container at least comprises an outer medicine cylinder fixedly connected to the lower flow passage component; the dosing metering component at least comprises a rotary disc, the upper end surface of the rotary disc is provided with a plurality of quantitative medicine grooves, and the quantitative medicine grooves are uniformly distributed along the circumference of the rotary disc; the quantitative medicine groove is of a blind hole structure; the lower end of the outer cartridge case is provided with a lower opening end penetrating through the lower flow passage component, and the lower opening end is positioned on the circumference where the plurality of quantitative medicine grooves on the upper end surface of the rotary table are distributed.
A vibration gear and a spring are sequentially coaxially sleeved below the turntable; a circle of upper vibration teeth are arranged on the lower end surface of the turntable; a circle of lower vibration teeth are arranged on the upper end surface of the vibration gear; the tooth tips of the upper vibration teeth and the lower vibration teeth are arranged oppositely to form a unidirectional ratchet wheel rotation motion pair.
At least one pawl structure is arranged on the outer edge of the rotary disc, and the pawl structure consists of a pawl arm connected with the outer edge of the rotary disc and a pawl end part positioned at one end of the pawl arm; at least one-way open slot 1-1 is arranged at the position, corresponding to the position of the turntable, on the inner wall of the lower shell; the end part of the pawl is positioned on the same horizontal plane with the one-way open slot (the position of the one-way open slot is shown in figure 5).
The rotary cover, the spring, the vibration gear, the rotary disc and the outer medicine cylinder arranged on the lower component of the flow passage form a vibration medicine storage unit of the powder aerosol administration device.
As a basic structure of the present powder inhalation drug delivery device, the powder storage container includes only the outer cartridge 14a fixed to the lower flow path member.
The rotary cover, the spring, the vibration gear, the rotary disc and the outer medicine cylinder arranged on the lower component of the flow passage form a vibration medicine storage unit of the powder aerosol administration device.
As a further alternative of this solution, an inner cartridge 14 can also be arranged in the outer cartridge, said inner cartridge being nested in said outer cartridge, said inner cartridge being freely movable in said outer cartridge.
The rotary cover, the spring, the vibration gear, the rotary disc and the inner and outer medicine barrels arranged on the lower component of the flow passage form a composite vibration medicine storage unit of the powder inhalation administration device.
In this alternative, the vibrating gear serves as the primary vibrating member and the inner cartridge serves as the secondary vibrating member.
In this alternative, the powder aerosol medicament powder (or called medicament powder) filled in the outer cartridge can be sufficiently vibrated by the free movement of the inner cartridge in the outer cartridge.
Since the inner drug cylinder in the outer drug cylinder is not a necessary basic component and belongs to an optional component, in the expression of the technical scheme, except for the specific points, all the other parts related to the vibration drug storage unit of the aerosol drug delivery device can be regarded as common descriptions of the vibration drug storage unit without the inner drug cylinder or the composite vibration drug storage unit with the inner drug cylinder, and are not described separately to avoid repetition.
The lower flow passage component, the rotary disc, the quantitative medicine groove, the outer medicine cylinder and the inner medicine cylinder form a medicine feeding metering component of the powder aerosol medicine feeding device.
In the practical operation process, when the rotary cap 8 rotates to a certain angle (called as a first rotation angle, for example, 60 °) along the first rotation direction (counterclockwise rotation direction seen from the top of the powder aerosol administration device in plan view), the rotary cap will drive the vibration gear 12 to rotate, at this time, the rotary disk cannot rotate under the action of the one-way limiting structure of the three pawls 3c and the limiting grooves arranged on the circumference of the rotary disk, and the vibration gear and the rotary disk generate relative motion (coaxial reverse rotation), because the upper and lower vibration teeth 3b and 12a are respectively arranged on the combined end surface of the vibration gear and the rotary disk, when the relative motion (coaxial reverse rotation) is generated between the vibration gear and the rotary disk, under the elastic force of the spring 13, the two sets of vibration teeth 3b and 12a are mutually staggered, so that the vibration gear moves up and down, and the rotary disk is continuously knocked, generating a longitudinal integral vibration effect which is transmitted to the outer cartridge on the lower component of the flow channel through the turntable to generate a first heavy vibration effect; meanwhile, the turntable can synchronously transmit the knocking vibration of the vibration gear to an inner medicine cylinder in the outer medicine cylinder to drive the inner medicine cylinder to freely vibrate in the outer medicine cylinder; the synchronous vibration of the inner medicine cylinder produces a second vibration effect, so that the medicine powder in the medicine powder storage container can flow into the quantitative medicine groove more uniformly and stably, and the metering accuracy of the single dose of medicine powder supplied by the medicine powder storage container can be better ensured in each medicine feeding process of the powder inhalation medicine feeding device.
According to the method for improving the dosing accuracy of the powder inhalation dosing device, the vibrating gear is adopted, the component under the runner is subjected to integral knocking type vibration through the rotary table, so that a better integral vibration effect is generated, meanwhile, the requirement on the material strength of the vibrating component can be reduced, the design, the manufacture and the manufacturing cost of a product are facilitated, the good adaptability of the powder inhalation dosing device to wider range of medicine powder types is improved, and the adverse effect on the dosing accuracy caused by poor flowability of powder inhalation powder is overcome.
When the technical scheme is implemented, the strength of the whole vibration effect of the medicine storage unit can be adjusted by changing the number and the height of the vibration teeth and the elasticity of the spring, and the metering accuracy of the medicine powder adding amount is improved.
When the technical scheme is implemented, the dosage metering accuracy of single dose of medicinal powder can be further adjusted and ensured by adjusting the included angle of the bottom edges of the inner and outer medicament cylinders and the mass of the inner medicament cylinder according to the flowability index of the medicinal powder, so that the powder inhalation drug delivery device has good medicament powder type adaptability and convenience in design and adjustment of mechanical structure parameters.
In the technical scheme of the invention, the compound vibration medicine storage unit takes the vibration gear as a main vibration part to vibrate the medicine powder storage container integrally, and simultaneously, the inner medicine cylinder capable of synchronously and freely vibrating is arranged in the medicine powder storage container to serve as an auxiliary vibration part to carry out double vibration on medicine powder in the medicine powder storage container, so that the metering accuracy of single-dose medicine powder supplied by the whole powder aerosol medicine feeding device is better ensured, the good adaptability of the powder aerosol medicine feeding device to various medicine powder types is increased, and the adverse influence of the poor flowability of powder on the dosing accuracy is overcome.
As can be seen from fig. 3, a cartridge cover 15 is provided at the upper end of the outer cartridge, and the turntable, the outer cartridge and the cartridge cover form a closed space in which the inner cartridge can move freely, which may be a longitudinal movement of the inner cartridge along the longitudinal axis of the outer cartridge, a lateral movement of the inner cartridge in the outer cartridge, a combination of a longitudinal and a lateral movement of the inner cartridge in the outer cartridge, or an irregular movement of the inner cartridge in the outer cartridge.
The inner medicine barrel can freely move in the outer medicine barrel, so that the powder inhalation medicine powder (or called medicine powder) filled in the outer medicine barrel can be fully vibrated, and can more uniformly and stably flow into the quantitative medicine groove.
As can be seen from fig. 1, 2 or 4, the spring, the oscillating gear and the turntable are arranged coaxially.
As shown in figures 1 and 2, the tooth tips of the upper and lower vibrating teeth are oppositely arranged to form a unidirectional ratchet wheel rotating pair.
Furthermore, the upper vibrating teeth are annularly and uniformly distributed on the lower end surface of the rotary table by taking the rotation center of the rotary table as the circle center; the lower vibrating teeth are annularly and uniformly distributed on the upper end surface of the vibrating gear by taking the rotating center of the vibrating gear as a circle center.
As shown in fig. 1 and 2, the upper and lower vibrating teeth are unidirectional bevel teeth.
In the present embodiment, the first rotational direction is viewed as a counterclockwise rotational direction from the top of the powder inhalation delivery device.
Since the two sets of unidirectional bevel teeth with opposite tooth tips are used for generating impact and knocking vibration, which are common means in mechanical design, the action principle, process and vibration generation mechanism are not described herein.
According to the technical scheme, the runner lower member is subjected to integral knocking type vibration through the turntable, so that a better integral vibration effect can be generated, the requirement on the material strength of the vibration member can be lowered, and the design, the manufacture and the manufacturing cost of a product can be favorably reduced; the medicine storage unit is subjected to double compound vibration by adopting a main vibration component structure and a secondary vibration component structure, so that the metering accuracy of the medicine powder amount supplied by the medicine storage unit in each administration process of the whole powder inhalation administration device can be better ensured; through the arrangement of the inner medicine cylinder, the workload of mechanical structure design change required by the change of the flowability of the filled medicine powder can be reduced, the good adaptability of the powder inhalation dosing device to a wider range of medicine powder types is increased, and the adverse effect on the dosing accuracy caused by the poor flowability of the powder inhalation dosing device is overcome.
The invention can be widely applied to the design and manufacture fields of powder aerosol administration devices with various specifications.
Claims (10)
1. A method for improving the dosing accuracy of a powder aerosol dosing device comprises a powder storage container and a dosing metering component which are arranged in a shell of the dosing device, wherein a suction nozzle is arranged on the outer side of the shell, a flow passage component is arranged in the shell, and the flow passage component is sequentially connected with an air inlet, the dosing metering component and the suction nozzle through an air path; the drug delivery device shell consists of an upper cover, a shell and a lower shell which are coaxially sleeved in sequence, and a spiral cover is arranged at the lower end of the lower shell; the runner component consists of an upper runner component and a lower runner component which are buckled into an integral structure to form a complete runner gas circuit; the method is characterized in that:
the medicine powder storage container at least comprises an outer medicine cylinder fixedly connected to the lower flow passage component;
the dosing metering component at least comprises a rotary disc, the upper end surface of the rotary disc is provided with a plurality of quantitative medicine grooves, and the quantitative medicine grooves are uniformly distributed along the circumference of the rotary disc; the quantitative medicine groove is of a blind hole structure;
the lower end of the outer cartridge is provided with a lower opening end penetrating through the lower flow passage component, and the lower opening end is positioned on the circumference of the upper end surface of the rotary table where a plurality of quantitative medicine grooves are distributed;
a vibration gear and a spring are sequentially coaxially sleeved below the turntable;
a circle of upper vibration teeth are arranged on the lower end surface of the turntable; a circle of lower vibration teeth are arranged on the upper end surface of the vibration gear; the tooth tips of the upper vibration teeth and the lower vibration teeth are arranged oppositely to form a one-way ratchet wheel rotating kinematic pair:
at least one pawl structure is arranged on the outer edge of the rotary disc, and the pawl structure consists of a pawl arm connected with the outer edge of the rotary disc and a pawl end part positioned at one end of the pawl arm;
at least one-way open slot is formed in the position, corresponding to the position of the rotary table, on the inner wall of the lower shell;
the end part of the pawl is positioned on the same horizontal plane with the one-way open slot;
the rotary cover, the spring, the vibration gear, the rotary disc and the outer medicine cylinder arranged on the lower component of the flow channel form a vibration medicine storage unit of the powder inhalation administration device;
the rotary cover is used for driving the dosing metering component and the vibration medicine storage unit to work, and the dosing metering function and the vibration function of the medicine storage unit are respectively realized;
the vibration gear provides a vibration source for the rotary disc and the medicine storage unit under the action of the spring;
an inner medicine cylinder is arranged in the outer medicine cylinder, and the inner medicine cylinder can freely move in the outer medicine cylinder;
the rotary cover, the spring, the vibrating gear, the rotary disc and the inner and outer medicine barrels arranged on the lower component of the flow passage form a composite vibrating medicine storage unit of the powder inhalation administration device;
the vibration gear of the medicine bottle serves as a main vibration part, and the inner medicine cylinder serves as a secondary vibration part;
the powder inhalation dosing device adopts upper and lower vibrating teeth which are arranged oppositely, and realizes the vibrating function of the medicine storage unit through a vibration source provided for the turntable and the outer medicine barrel, so that the metering accuracy of the medicine powder amount supplied by the medicine storage unit in each dosing process of the whole powder inhalation dosing device is improved, and the whole dosing device has good medicine type adaptability and convenience for adjusting the vibration effect of mechanical structure parameter design;
the powder aerosol drug delivery device is characterized in that the vibration gear serves as a main vibration part to vibrate the powder storage container, the inner medicine barrel capable of synchronously and freely vibrating serves as a secondary vibration part in the powder storage container, and the powder aerosol drug powder filled in the outer medicine barrel is subjected to sufficient composite vibration through the free movement of the inner medicine barrel in the outer medicine barrel so as to further ensure the accuracy of the drug delivery quantity of the powder aerosol drug delivery device.
2. The method for improving the accuracy of dosing of a dry powder inhalation drug delivery device according to claim 1, wherein when the cap is rotated to a first rotation angle along a first rotation direction, the cap drives the vibrating teeth to rotate, at this time, the turntable does not rotate under the limit action of the pawl structure provided on the outer edge of the turntable, the vibrating gear and the turntable generate relative motion, and because the upper vibrating teeth and the lower vibrating teeth are respectively provided on the combined end surface of the vibrating gear and the turntable, when the vibrating gear and the turntable generate relative motion, the upper vibrating teeth and the lower vibrating teeth generate mutual staggering motion under the elastic force of the spring, so that the vibrating gear continuously strikes the turntable to generate a longitudinal vibration effect, and the vibration effect is transmitted to the outer cartridge located on the lower component of the flow channel through the turntable to generate a first heavy vibration effect.
3. The method of improving the dosing accuracy of a dry powder aerosol delivery device of claim 1 wherein said inner cartridge is nested within said outer cartridge; the inner cartridge is a hollow tubular structure, and the diameter of the lower end of the inner cartridge is smaller than that of the upper end of the inner cartridge; the longitudinal section structure of the inner medicine cylinder wall is an inverted isosceles trapezoid structure with a large upper part and a small lower part.
4. The method for improving the dosing accuracy of a dry powder inhalation drug delivery device according to claim 3, wherein the rotary disk synchronously transmits the knocking vibration of the vibration gear to the inner drug cylinder in the outer drug cylinder to drive the inner drug cylinder to freely vibrate in the outer drug cylinder while the rotary cover rotates to a first rotation angle along a first rotation direction to generate a first heavy vibration effect; the synchronous vibration of the inner cartridge case has a second vibration effect on the powder inhalation drug powder filled in the outer cartridge case, so that the drug powder in the drug powder storage container can flow into the quantitative drug groove more uniformly and stably, and the metering accuracy of the single dose of drug powder supplied by the drug powder storage container can be better ensured in each drug administration process of the powder inhalation drug administration device.
5. The method of improving the dosing accuracy of a dry powder aerosol delivery device according to claim 2 or 4, wherein the first rotation angle is 360 degrees per number of detent structures.
6. The method for improving the dosing accuracy of a dry powder aerosol delivery device according to claim 2 or 4, wherein the first rotation angle is 360 degrees per number of one-way open slots.
7. The method for improving the dosing accuracy of a powder inhalation drug delivery device according to claim 1 or 4, wherein the method for improving the dosing accuracy of the powder inhalation drug delivery device adjusts the intensity of the whole vibration effect of the drug storage unit by changing the number of the upper and lower vibrating teeth, the tooth height and the elastic force of the spring, thereby improving the dosing accuracy of the powder drug.
8. The method for improving the accuracy of the dosing of the dry powder inhalation drug delivery device according to claim 1, wherein the method for improving the accuracy of the dosing of the dry powder inhalation drug delivery device is characterized in that the vibration gear and the rotary table are used for carrying out integral knocking type vibration on the component below the flow channel, so that a better integral vibration effect is achieved, the requirement on the material strength of the vibration component is reduced, the design, the manufacture and the manufacturing cost of a product are facilitated, the good adaptability of the dry powder inhalation drug delivery device to a wider range of drug powder types is increased, and the adverse effect of poor flowability of the dry powder inhalation powder on the accuracy of the dosing is overcome.
9. The method for improving the accuracy of the dosing of the dry powder inhalation drug delivery device according to claim 1, wherein the upper vibrating teeth are annularly and uniformly distributed on the lower end surface of the rotary table with the center of rotation of the rotary table as the center of circle; the lower vibrating teeth are annularly and uniformly distributed on the upper end surface of the vibrating gear by taking the rotating center of the vibrating gear as a circle center.
10. The method of improving the dosing accuracy of a dry powder aerosol delivery device according to claim 1 wherein the first rotational direction is viewed as a counterclockwise rotational direction from the top of the dry powder aerosol delivery device.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510374266.7A CN105031782B (en) | 2015-06-30 | 2015-06-30 | Method for improving dosing quantity metering accuracy of powder inhalation dosing device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510374266.7A CN105031782B (en) | 2015-06-30 | 2015-06-30 | Method for improving dosing quantity metering accuracy of powder inhalation dosing device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105031782A CN105031782A (en) | 2015-11-11 |
| CN105031782B true CN105031782B (en) | 2020-06-26 |
Family
ID=54439128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510374266.7A Active CN105031782B (en) | 2015-06-30 | 2015-06-30 | Method for improving dosing quantity metering accuracy of powder inhalation dosing device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105031782B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017128170A1 (en) * | 2016-01-28 | 2017-08-03 | 扬子江药业集团有限公司 | Reservoir-type dry powder inhaler |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2364649A (en) * | 2000-05-17 | 2002-02-06 | Orion Corp | Inhaler with Dose Counter |
| CN1810312A (en) * | 1997-03-14 | 2006-08-02 | 阿斯特拉公司 | Inhalation device |
| WO2007045904A1 (en) * | 2005-10-22 | 2007-04-26 | 42 Technology Limited | Dose counter for inhalation devices |
| CN102218182A (en) * | 2011-06-13 | 2011-10-19 | 上海秀新臣邦医药科技有限公司 | Vibrating dosing device for dry power dosing device |
| CN102228725A (en) * | 2011-06-13 | 2011-11-02 | 上海秀新臣邦医药科技有限公司 | Dry powder administration device |
-
2015
- 2015-06-30 CN CN201510374266.7A patent/CN105031782B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1810312A (en) * | 1997-03-14 | 2006-08-02 | 阿斯特拉公司 | Inhalation device |
| GB2364649A (en) * | 2000-05-17 | 2002-02-06 | Orion Corp | Inhaler with Dose Counter |
| WO2007045904A1 (en) * | 2005-10-22 | 2007-04-26 | 42 Technology Limited | Dose counter for inhalation devices |
| CN102218182A (en) * | 2011-06-13 | 2011-10-19 | 上海秀新臣邦医药科技有限公司 | Vibrating dosing device for dry power dosing device |
| CN102228725A (en) * | 2011-06-13 | 2011-11-02 | 上海秀新臣邦医药科技有限公司 | Dry powder administration device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105031782A (en) | 2015-11-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6488648B1 (en) | Device for feeding a powder in a predetermined amount and method thereof | |
| ES2266201T3 (en) | MULTIPLE DOSE ADMINISTRATOR DEVICE FOR POWDER MEDICINE. | |
| CN104971411B (en) | Powder fog agent dosing device | |
| US7281539B2 (en) | Medicament container | |
| CN101980739B (en) | Inhalation device | |
| CN102218182B (en) | Vibrating dosing device for dry power dosing device | |
| CN104971415B (en) | Double-vibration medicine storage unit of powder inhalation administration device | |
| KR101839937B1 (en) | Improvements relating to medicament delivery devices | |
| CN104971412B (en) | Vibration medicine storage unit of powder inhalation dosing device | |
| CN104971413B (en) | Anti-misoperation unit and anti-misoperation method of powder aerosol dosing device | |
| CN105031781B (en) | Method for controlling accuracy of medicine supply quantity of powder aerosol dosing device | |
| CN105031782B (en) | Method for improving dosing quantity metering accuracy of powder inhalation dosing device | |
| CN107737393B (en) | Preparation atomization flow passage for powder aerosol inhalation device | |
| WO2017128170A1 (en) | Reservoir-type dry powder inhaler | |
| CN204766902U (en) | Powder spray device of dosing | |
| CN204766907U (en) | Powder spray is dosed two vibrations of device and is stored up prescriptions unit | |
| CN204766904U (en) | Powder spray is dosed vibration of device and is stored up prescription unit | |
| CN204766905U (en) | Powder spray dose device prevent mistake operational unit | |
| CN202122750U (en) | Vibration type medicine feeding device for inhalation type dry powder medicine feeding device | |
| CN110464930B (en) | Coaxial vibration gear for vibration administration unit of storage type dry powder inhalation administration device | |
| US20150202392A1 (en) | Metering element for an inhalation device and inhalation device comprising a metering element | |
| CN117771490A (en) | Double-reservoir powder aerosol device | |
| US20160051777A1 (en) | Metering element for an inhalation device and assembly for an inhalation device containing same | |
| MXPA00008779A (en) | Device and method for feeding a constant amount of powder body |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| CB02 | Change of applicant information |
Address after: 201203 Shanghai City, Pudong New Area Zhangjiang hi tech park Zuchongzhi Road No. 1500 Building 8 Room 107 Applicant after: Shanghai Chen state pharmaceutical Polytron Technologies Inc Address before: 201203 Shanghai City, Pudong New Area Zhangjiang hi tech park Zuchongzhi Road No. 1500 Building 8 Room 107 Applicant before: Shanghai Chenpon Pharmaceutical Technology Co., Ltd. |
|
| CB02 | Change of applicant information | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |