CN104997928A - Traditional Chinese medicine lotion for external use for treating closed physical exercise soft tissue injury - Google Patents
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Abstract
Description
技术领域technical field
本发明涉及一种治疗闭合性体育运动软组织损伤的中药外用洗剂。The invention relates to a traditional Chinese medicinal external lotion for treating closed sports soft tissue injuries.
背景技术Background technique
闭合性体育运动软组织损伤指软组织或骨骼肌肉受到直接或间接暴力,或长期慢性劳损引起的一大类创伤综合征。组织受创后出现微循环障碍、无菌性炎症,致使局部肿胀疼痛。软组织损伤包括刀枪、摔伤、殴打、挫伤、穿刺伤、擦伤、运动损伤等,伤处多有疼痛、肿胀、出血或骨折、脱臼等,广义上也包括一些内脏损伤。对于体育运动员、武术运动员、体育爱好者、武术爱好者等,在训练、运动或比赛时,经常会受伤,比如摔伤、擦伤、挫伤、运动损伤等。软组织损伤若不及时治疗,有可能加重,因此,需要一种疗效好、见效快的药物。Closed sports soft tissue injuries refer to a large category of trauma syndromes caused by direct or indirect violence to soft tissues or skeletal muscles, or long-term chronic strain. Microcirculation disorder and aseptic inflammation appear after tissue trauma, resulting in local swelling and pain. Soft tissue injuries include knife and gun injuries, falls, beatings, contusions, puncture injuries, abrasions, sports injuries, etc. The injuries often include pain, swelling, bleeding or fractures, dislocations, etc. In a broad sense, it also includes some visceral injuries. For sports athletes, martial arts players, sports enthusiasts, martial arts enthusiasts, etc., they are often injured during training, sports or competitions, such as falls, bruises, contusions, sports injuries, etc. If the soft tissue injury is not treated in time, it may increase the weight of the disease. Therefore, a drug with good curative effect and quick effect is needed.
发明内容Contents of the invention
针对上述现有技术,本发明提供了一种治疗闭合性体育运动软组织损伤的中药外用洗剂,其具有疗效好、见效快等优点。Aiming at the above-mentioned prior art, the present invention provides a traditional Chinese medicine external lotion for treating blunt sports soft tissue injury, which has the advantages of good curative effect and quick effect.
本发明是通过以下技术方案实现的:The present invention is achieved through the following technical solutions:
一种治疗闭合性体育运动软组织损伤的中药外用洗剂,是由以下原料药制成的:元胡30~40克,玄参20~30克,野地瓜20~30克,米口袋30~40克,金钱草10~20克,萹蓄30~40克,萝藦子20~30克,威灵仙10~20克,薄荷10~20克,油松节20~30克。A traditional Chinese medicine external lotion for treating closed sports soft tissue injuries, which is made of the following raw materials: 30-40 grams of Yuanhu, 20-30 grams of Scrophulariaceae, 20-30 grams of wild sweet potatoes, 30-40 grams of rice bags gram, 10-20 grams of Desmodium, 30-40 grams of succulents, 20-30 grams of radish, 10-20 grams of Clematis, 10-20 grams of mint, and 20-30 grams of Chinese pine knots.
优选的,是由以下原料药制成的:元胡35克,玄参25克,野地瓜25克,米口袋35克,金钱草15克,萹蓄35克,萝藦子25克,威灵仙15克,薄荷15克,油松节25克。Preferably, it is made of the following raw materials: Yuanhu 35 grams, Scrophulariaceae 25 grams, wild sweet potato 25 grams, rice bag 35 grams, money grass 15 grams, 35 grams of radish, radish 25 grams, Weiling 15 grams of celestial beings, 15 grams of mint, and 25 grams of pine knots.
所述治疗闭合性体育运动软组织损伤的中药外用洗剂的制备方法为:首先,取元胡、玄参、野地瓜、米口袋、金钱草、萹蓄、萝藦子和威灵仙,混合,加水浸没,浸泡2小时,煎煮80~100分钟,过滤得滤液,减压浓缩至相对密度为1.30~1.35(50℃测)的稠膏;取薄荷和油松节,加入8倍量(重量倍数)的水,蒸馏提取挥发油;将挥发油与稠膏混合,再加入50ml甘油,加水至500ml,混匀,即得。The preparation method of the traditional Chinese medicine external lotion for the treatment of blunt sports soft tissue injury is as follows: first, take Yuanhu, Scrophulariaceae, wild sweet potato, rice bag, desmodium sylvestris, chrysanthemum, radish and clematis, mix, Submerged in water, soaked for 2 hours, decocted for 80-100 minutes, filtered to obtain the filtrate, concentrated under reduced pressure to a thick paste with a relative density of 1.30-1.35 (measured at 50°C); take mint and turpentine oil, add 8 times the amount (weight times) of water, distill and extract the volatile oil; mix the volatile oil with the thick paste, then add 50ml of glycerin, add water to 500ml, mix well, and you get it.
所述治疗闭合性体育运动软组织损伤的中药外用洗剂,为局部外用药物,具有舒筋活络、消炎、镇痛和改善血液微循环之功效,可用于由直接或间接暴力引起的急慢性软组织损伤。用时摇匀,喷抹于患处(同时辅助以轻快柔和的按摩,效果更佳),每日4~6次,通常1天内见效,疼痛减轻,3~8天即可消肿治愈。本发明的药物具有疗效好、见效快等优点。The traditional Chinese medicine external lotion for treating closed sports soft tissue injury is a topical external drug, which has the functions of relaxing tendons and activating collaterals, reducing inflammation, analgesia and improving blood microcirculation, and can be used for acute and chronic soft tissue injuries caused by direct or indirect violence . Shake well when using, spray on the affected area (at the same time, assist with light and soft massage, the effect is better), 4 to 6 times a day, usually within 1 day, the pain is relieved, and the swelling can be reduced and cured in 3 to 8 days. The medicine of the invention has the advantages of good curative effect, quick effect and the like.
具体实施方式Detailed ways
下面结合实施例对本发明作进一步的说明。The present invention will be further described below in conjunction with embodiment.
实施例1制备治疗闭合性体育运动软组织损伤的中药外用洗剂Embodiment 1 prepares the Chinese medicine external lotion for the treatment of blunt sports soft tissue injury
原料药配方为:元胡35克,玄参25克,野地瓜25克,米口袋35克,金钱草15克,萹蓄35克,萝藦子25克,威灵仙15克,薄荷15克,油松节25克。The formula of raw materials is: 35 grams of Yuanhu, 25 grams of Scrophulariaceae, 25 grams of wild sweet potato, 35 grams of rice pocket, 15 grams of money grass, 35 grams of scallops, 25 grams of radish, 15 grams of clematis, and 15 grams of mint , turpentine oil 25 grams.
制备方法为:首先,取元胡、玄参、野地瓜、米口袋、金钱草、萹蓄、萝藦子和威灵仙,混合,加水浸没,浸泡2小时,煎煮90分钟,过滤得滤液,减压浓缩至相对密度为1.35(50℃测)的稠膏;取薄荷和油松节,加入8倍量(重量倍数)的水,蒸馏提取挥发油;将挥发油与稠膏混合,再加入50ml甘油,加水至500ml,混匀,即得。The preparation method is as follows: firstly, take Yuanhu, Scrophulariae, wild sweet potato, rice bag, money grass, scorpion, radish and clematis, mix them, add water to immerse, soak for 2 hours, decoct for 90 minutes, and filter to obtain the filtrate , concentrated under reduced pressure to a thick paste with a relative density of 1.35 (measured at 50°C); get peppermint and turpentine oil, add 8 times the amount (weight multiple) of water, distill and extract the volatile oil; mix the volatile oil with the thick paste, and then add 50ml Glycerin, add water to 500ml, mix well, that is.
实施例2制备治疗闭合性体育运动软组织损伤的中药外用洗剂Embodiment 2 prepares the Chinese medicine external lotion for the treatment of blunt sports soft tissue injury
原料药配方为:元胡30克,玄参20克,野地瓜30克,米口袋40克,金钱草10克,萹蓄30克,萝藦子28克,威灵仙13克,薄荷15克,油松节25克。The formula of the raw material medicine is: Yuanhu 30g, Scrophulariaceae 20g, wild sweet potato 30g, rice bag 40g, Desmodium 10g, 萹草30g, radish 28g, clematis 13g, mint 15g , turpentine oil 25 grams.
制备方法为:首先,取元胡、玄参、野地瓜、米口袋、金钱草、萹蓄、萝藦子和威灵仙,混合,加水浸没,浸泡2小时,煎煮80分钟,过滤得滤液,减压浓缩至相对密度为1.35(50℃测)的稠膏;取薄荷和油松节,加入8倍量(重量倍数)的水,蒸馏提取挥发油;将挥发油与稠膏混合,再加入50ml甘油,加水至500ml,混匀,即得。The preparation method is as follows: firstly, take Yuanhu, Scrophulariae, wild sweet potato, rice bag, money grass, scorpion, radish and clematis, mix them, add water to immerse, soak for 2 hours, decoct for 80 minutes, and filter to obtain the filtrate , concentrated under reduced pressure to a thick paste with a relative density of 1.35 (measured at 50°C); get peppermint and turpentine oil, add 8 times the amount (weight multiple) of water, distill and extract the volatile oil; mix the volatile oil with the thick paste, and then add 50ml Glycerin, add water to 500ml, mix well, that is.
实施例3制备治疗闭合性体育运动软组织损伤的中药外用洗剂Embodiment 3 prepares the Chinese medicine external lotion for the treatment of blunt sports soft tissue injury
原料药配方为:元胡40克,玄参30克,野地瓜20克,米口袋30克,金钱草20克,萹蓄40克,萝藦子23克,威灵仙17克,薄荷12克,油松节28克。The formula of the raw material medicine is: 40 grams of Yuanhu, 30 grams of Scrophulariaceae, 20 grams of wild sweet potato, 30 grams of rice pocket, 20 grams of Desmodium, 40 grams of Cucumber, 23 grams of radish, 17 grams of Clematis, 12 grams of mint , pine knot 28 grams.
制备方法为:首先,取元胡、玄参、野地瓜、米口袋、金钱草、萹蓄、萝藦子和威灵仙,混合,加水浸没,浸泡2小时,煎煮100分钟,过滤得滤液,减压浓缩至相对密度为1.35(50℃测)的稠膏;取薄荷和油松节,加入8倍量(重量倍数)的水,蒸馏提取挥发油;将挥发油与稠膏混合,再加入50ml甘油,加水至500ml,混匀,即得。The preparation method is as follows: First, take Yuanhu, Scrophulariae, wild sweet potato, rice bag, money grass, scorpion, radish and clematis, mix them, add water to immerse, soak for 2 hours, decoct for 100 minutes, and filter to obtain the filtrate , concentrated under reduced pressure to a thick paste with a relative density of 1.35 (measured at 50°C); get peppermint and turpentine oil, add 8 times the amount (weight multiple) of water, distill and extract the volatile oil; mix the volatile oil with the thick paste, and then add 50ml Glycerin, add water to 500ml, mix well, that is.
实施例4制备治疗闭合性体育运动软组织损伤的中药外用洗剂Embodiment 4 prepares the Chinese medicine external lotion for the treatment of blunt sports soft tissue injury
原料药配方为:元胡32克,玄参28克,野地瓜23克,米口袋37克,金钱草15克,萹蓄33克,萝藦子20克,威灵仙20克,薄荷10克,油松节30克。The formula of raw materials is: 32 grams of Yuanhu, 28 grams of Scrophulariae, 23 grams of wild sweet potato, 37 grams of rice pocket, 15 grams of money grass, 33 grams of scallops, 20 grams of radish, 20 grams of clematis, and 10 grams of mint , turpentine oil 30 grams.
制备方法为:首先,取元胡、玄参、野地瓜、米口袋、金钱草、萹蓄、萝藦子和威灵仙,混合,加水浸没,浸泡2小时,煎煮90分钟,过滤得滤液,减压浓缩至相对密度为1.33(50℃测)的稠膏;取薄荷和油松节,加入8倍量(重量倍数)的水,蒸馏提取挥发油;将挥发油与稠膏混合,再加入50ml甘油,加水至500ml,混匀,即得。The preparation method is as follows: firstly, take Yuanhu, Scrophulariae, wild sweet potato, rice bag, money grass, scorpion, radish and clematis, mix them, add water to immerse, soak for 2 hours, decoct for 90 minutes, and filter to obtain the filtrate , concentrated under reduced pressure to a thick paste with a relative density of 1.33 (measured at 50°C); get peppermint and turpentine oil, add 8 times the amount (weight multiple) of water, distill and extract the volatile oil; mix the volatile oil with the thick paste, and then add 50ml Glycerin, add water to 500ml, mix well, that is.
实施例5制备治疗闭合性体育运动软组织损伤的中药外用洗剂Embodiment 5 prepares the Chinese medicine external lotion for the treatment of blunt sports soft tissue injury
原料药配方为:元胡37克,玄参24克,野地瓜25克,米口袋33克,金钱草18克,萹蓄35克,萝藦子30克,威灵仙10克,薄荷20克,油松节20克。The formula of raw materials is: Yuanhu 37g, Scrophulariaceae 24g, wild sweet potato 25g, rice bag 33g, Desmodium 18g, 萹草 35g, radish 30g, clematis 10g, mint 20g , pine knot 20 grams.
制备方法为:首先,取元胡、玄参、野地瓜、米口袋、金钱草、萹蓄、萝藦子和威灵仙,混合,加水浸没,浸泡2小时,煎煮90分钟,过滤得滤液,减压浓缩至相对密度为1.35(50℃测)的稠膏;取薄荷和油松节,加入8倍量(重量倍数)的水,蒸馏提取挥发油;将挥发油与稠膏混合,再加入50ml甘油,加水至500ml,混匀,即得。The preparation method is as follows: firstly, take Yuanhu, Scrophulariae, wild sweet potato, rice bag, money grass, scorpion, radish and clematis, mix them, add water to immerse, soak for 2 hours, decoct for 90 minutes, and filter to obtain the filtrate , concentrated under reduced pressure to a thick paste with a relative density of 1.35 (measured at 50°C); get peppermint and turpentine oil, add 8 times the amount (weight multiple) of water, distill and extract the volatile oil; mix the volatile oil with the thick paste, and then add 50ml Glycerin, add water to 500ml, mix well, that is.
临床资料clinical information
病例选择:本研究以选择肌肉、韧带、肌腱、筋膜等软组织直接或间接的风寒湿邪或暴力而产生疼痛、肿胀、瘀斑或患处功能障碍等病例作为受试对象。Case selection: In this study, the cases of pain, swelling, ecchymosis or dysfunction of the affected area caused by direct or indirect wind-cold-dampness or violence in soft tissues such as muscles, ligaments, tendons, and fascia were selected as subjects.
纳入病例标准:凡由外伤劳损外邪引起的肌肉、韧带、肌腱、筋膜等软组织闭合性损伤的患者均可纳入试验病例。Criteria for inclusion of cases: All patients with closed injuries of muscles, ligaments, tendons, fascia and other soft tissues caused by traumatic strains can be included in the experimental cases.
排除病例标准:Criteria for excluding cases:
1、由骨折后引起的周围软组织损伤。1. The surrounding soft tissue injury caused by the fracture.
2、由肿瘤所致的周围软组织损伤。2. Surrounding soft tissue damage caused by the tumor.
3、由颈、腰椎间盘突出造成的周围软组织损伤。3. Surrounding soft tissue damage caused by cervical and lumbar disc herniation.
4、皮肤有破损或溃疡者。4. Those with damaged or ulcerated skin.
5、年龄在18岁以下或65岁以上者,妊娠或哺乳期妇女,有药物接触过敏史者。5. Those under the age of 18 or over 65 years old, pregnant or breastfeeding women, and those with a history of drug contact allergy.
6、合并心血管、肝、肾和造血系统等严重原发病者,精神病患者。6. Patients with serious primary diseases such as cardiovascular, liver, kidney and hematopoietic systems, and mentally ill patients.
7、不符合纳入标准,未按规定用药,无法判断疗效或资料不全等影响疗效或安全性判断者。7. Those who do not meet the inclusion criteria, do not take medication according to the regulations, cannot judge the curative effect or have incomplete data, etc., which affect the judgment of curative effect or safety.
共接收患者235例,其中,男147例,女88例,急性软组织损伤84例,慢性软组织损伤151例。A total of 235 patients were received, including 147 males, 88 females, 84 cases of acute soft tissue injury, and 151 cases of chronic soft tissue injury.
治疗方法:采用实施例1制备的药物进行治疗,用时摇匀,喷抹于患处(同时辅助以轻快柔和的按摩),每日4~6次。治疗6天后观察统计疗效(6天内治愈者停止治疗)。Therapeutic method: adopt the medicine prepared in embodiment 1 to treat, shake well when using, spray on the affected part (simultaneously assist with light and soft massage), 4 to 6 times a day. After 6 days of treatment, the curative effect was observed and statistically determined (those cured within 6 days stopped the treatment).
疗效评价标准:Efficacy evaluation criteria:
治愈:用药后局部疼痛、肿胀及皮肤瘀斑均消失,功能活动恢复正常。Cure: after treatment, local pain, swelling and skin ecchymosis all disappeared, and functional activities returned to normal.
显效:用药后局部疼痛、肿胀及皮肤瘀斑均有明显减轻,功能活动基本恢复正常。Significantly effective: local pain, swelling and skin ecchymosis are all significantly relieved after medication, and functional activities basically return to normal.
有效:用药后局部疼痛、肿胀及皮肤瘀斑均有减轻,功能活动未恢复正常。Effective: Local pain, swelling, and skin ecchymosis were all relieved after medication, and functional activities did not return to normal.
无效:用药后局部疼痛、肿胀及皮肤瘀斑未见好转,功能活动未恢复正常。Ineffective: Local pain, swelling and skin ecchymosis did not improve after medication, and functional activities did not return to normal.
治疗结果:急性软组织损伤84例患者中,治愈45例,显效23例,有效14例,无效2例,总有效率97.6%。慢性软组织损伤151例患者中,治愈28例,显效78例,有效38例,无效7例,总有效率95.4%。Treatment results: Among the 84 patients with acute soft tissue injury, 45 cases were cured, 23 cases were markedly effective, 14 cases were effective, and 2 cases were ineffective. The total effective rate was 97.6%. Of the 151 patients with chronic soft tissue injury, 28 were cured, 78 were markedly effective, 38 were effective, and 7 were ineffective. The total effective rate was 95.4%.
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Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102641338A (en) * | 2012-05-15 | 2012-08-22 | 山东省血液中心 | Massage medicament for treating soft tissue injury |
-
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---|---|---|---|---|
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Non-Patent Citations (1)
Title |
---|
李彬之等: "《现代中医奇效良方宝典(下)》", 30 September 1997, 上海科学普及出版社 * |
Cited By (1)
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---|---|---|---|---|
CN105902901A (en) * | 2016-06-03 | 2016-08-31 | 高奎峰 | Traditional Chinese medicine for closed soft tissue injuries in physical sports |
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Inventor after: Wu Liang Inventor after: Tan Zuojun Inventor after: Gao Bo Inventor after: Yang Xiaomei Inventor after: Zhang Xiaodan Inventor after: Wang Jing Inventor after: Zheng Baoming Inventor before: Tan Zuojun Inventor before: Qiao Sujuan Inventor before: Wu Liang Inventor before: Wang Fachang Inventor before: Shao Shuhe |
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Application publication date: 20151028 |