CN104971092A - Traditional Chinese medicine compound preparation with antipyretic and anti-inflammatory effects as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine compound preparation with antipyretic and anti-inflammatory effects as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine compound preparation with antipyretic and anti-inflammatory effects. The traditional Chinese medicine compound preparation is characterized by being prepared from the following raw materials in parts by weight: 3-18 parts of fineleaf schizonepeta herb, 3-18 parts of divaricate saposhnikovia root, 3-15 parts of fermented soybean, 3-12 parts of dahurian angelica root, 3-24 parts of Szechuan lovage rhizome, 3-15 parts of incised notopterygium rhizome, 6-30 parts of Chinese thorowax root and 3-15 parts of licorice root. The antipyretic effect of the traditional Chinese medicine compound preparation disclosed by the invention is more durable compared with that of aspirin. Moreover, the invention also provides a preparation method and medical application of the traditional Chinese medicine compound preparation.
Description
Technical field
The present invention relates to a kind of compound Chinese medicinal preparation of antipyretic and anti-inflammatory; In addition, the invention still further relates to preparation method and the medical usage of this compound Chinese medicinal preparation.
Background technology
Within the long term of development of human history, infectious disease popular wide, sickness rate is high, the existence of the serious threat mankind and health.Along with the general advance of human society and preventive medicine, clinical medicine, preclinical medicine and pharmacy etc. develop rapidly, the struggle of the mankind and infectious disease achieves great successes, and its sickness rate and case fatality rate significantly decline.In recent years, especially since entering new century, some controlled infectious disease stage a comeback again, again popular, even beyond original popularity degree, particularly the outbreak of epidemic of 21 century first pestilence SARS in the whole world, makes us soul-stirring, what come one after another is bird flu and influenza A H1N1, again generates a panic in the world.Perceived control infectious diseases is the system engineering of a complexity and arduousness, is not only a hygienic issues, is also a severe social safety problem.
Within 2009, influenza A H1N1 epidemic situation is wreaked havoc in the whole world, and the continuous expansion of case radix makes world situation present complexity and unpredictability, Modern medical therapy method only has and takes neuraminidase inhibitor oseltamivir phosphate capsule in early days to suppress virus, and this single Therapeutic Method has started to occur Drug-resistant trend.Comprehensive analysis SARS, influenza A H1N1
[luo Yi, Ou Aihua, Yan Xia, etc. severe acute respiratory syndrome patients in emergency department TCM Syndrome Features analyzes [J]. Chinese combination of Chinese and Western medicine first aid magazine, 2003,10 (4): 201-203.; Open big king, beautiful light, Liu Qingquan, wait .123 example influenza A H1N1 serious symptom, critical illness Characteristics of traditional Chinese syndromes and pathogenic analysis [J]. Journal of Traditional Chinese Medicine, 2011,52 (1): 35-38.
], its case is mainly with fever caused by exogenous pathogenic factors performances such as heating, aversion to cold, coughs.
Chinese medicine have accumulated rich experience in the treatment of fever caused by exogenous pathogenic factors, and " Plain Questions heat opinion " specially a section refers: " Jin Fure patient, all typhoid fever and so on also." from the angle of broad sense, all fevers caused by exogenous pathogenic factors are referred to as typhoid fever, and found three YIN and three YANG, in order to summarize the Therapy regularity of fever caused by exogenous pathogenic factors.Eastern Han Dynasty Zhang Zhongjing treatise on Febrile Diseases is established fever caused by exogenous pathogenic factors the six channels and is distinguished the system of controlling, and gold dollar Liu interchannel, Wang Andao have started distinguishing of typhoid fever and epidemic febrile disease, but method of syndrome differentiation does not break away from the constraint of typhoid fever yet.Until Qing Dynasty's YE Tian shi " warm opinion " and Wu Ju Tong " Wenbing Tiaobian, Detailed Analysis of Epidemic Warm Diseases " have founded epidemic febrile disease defensive-qi-nutrient-blood and differentiation of syndrome according to the pathgenesis of SAN JIAO, become the independently dialectical theory of running neck and neck with typhoid fever differentiation of febrile diseases in accordance with the theory of the six meridians in fever caused by exogenous pathogenic factors, three together constitutes the method for syndrome differentiation of fever caused by exogenous pathogenic factors.
Puzzled the saying in modern medicine " infectious disease " of moderns, in addition pharmacological research achievement shows the product energy antiinflammatory antiviral of heat-clearing and toxic substances removing, fever caused by exogenous pathogenic factors treatment clinical mainly with cold and cool fall let out, Qingre Tongxia controls it, easily heavy dose of Flos Lonicerae, Fructus Forsythiae, Folium Isatidis, Radix Isatidis is used, the road of different non-determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs.Patient and his family provide patent medicine for oneself; antivirus oral liquid, QINGKAILING KOUFUYE, YINQIAO sheet, cow-bezoar anti-toxic bolus etc. nothing but; all cold and cool genus; the product in all bitter cold Great Cold such as Fructus Forsythiae, Flos Lonicerae, Gypsum Fibrosum, Radix Scutellariae, Rhizoma Coptidis, mountain mast, Calculus Bovis, Radix Et Rhizoma Rhei, Herba Houttuyniae; not only have the mistake that impairment of YANG is disappointing, Shang Youbing lies prostrate exopathogen, closes the worry that door stays bandit.Wrongly take the medicine of a cold nature, not only generate heat, have a headache, aversion to cold, aversion to wind do not understand, instead increase poor appetite, asthenia, just ward off, the resembling of the interior cold such as stomachache, therefore face the person's character that card carefully must distinguish heating, non-ly see that heat is with cold.
Utility model content
For the above-mentioned deficiency of existing Chinese medicine antipyretic and anti-inflammatory, according to embodiments of the invention, desirable to provide a kind of pharmacological action with antipyretic and anti-inflammatory, the compound Chinese medicinal preparation (hereinafter referred to as dispelling wind to relieve the exterior syndrome side) of the antipyretic and anti-inflammatory that refrigeration function is more lasting compared with aspirin, and its preparation method is provided.
According to embodiment, the compound Chinese medicinal preparation of a kind of antipyretic and anti-inflammatory provided by the invention, its innovative point is, is made up of the crude drug of following weight portion: Herba Schizonepetae 3-18 part, Radix Saposhnikoviae 3-18 part, Semen Sojae Preparatum 3-15 part, Radix Angelicae Dahuricae 3-12 part, Rhizoma Chuanxiong 3-24 part, Rhizoma Et Radix Notopterygii 3-15, Radix Bupleuri 6-30 part, Radix Glycyrrhizae 3-15 part.
According to an embodiment, in the compound Chinese medicinal preparation of the aforementioned antipyretic and anti-inflammatory of the present invention, the weight portion of crude drug is respectively: Herba Schizonepetae 9 parts, Radix Saposhnikoviae 9 parts, Semen Sojae Preparatum 9 parts, the Radix Angelicae Dahuricae 9 parts, Rhizoma Chuanxiong 9 parts, Rhizoma Et Radix Notopterygii 9 parts, Radix Bupleuri 9 parts, 3 parts, Radix Glycyrrhizae.
According to an embodiment, in the compound Chinese medicinal preparation of the aforementioned antipyretic and anti-inflammatory of the present invention, the weight portion of crude drug is respectively: Herba Schizonepetae 3 parts, Radix Saposhnikoviae 3 parts, Semen Sojae Preparatum 3 parts, the Radix Angelicae Dahuricae 3 parts, Rhizoma Chuanxiong 3 parts, Rhizoma Et Radix Notopterygii 3, Radix Bupleuri 6 parts, 3 parts, Radix Glycyrrhizae.
According to an embodiment, in the compound Chinese medicinal preparation of the aforementioned antipyretic and anti-inflammatory of the present invention, the weight portion of crude drug is respectively: Herba Schizonepetae 18 parts, Radix Saposhnikoviae 18 parts, Semen Sojae Preparatum 15 parts, the Radix Angelicae Dahuricae 12 parts, Rhizoma Chuanxiong 24 parts, Rhizoma Et Radix Notopterygii 15, Radix Bupleuri 30 parts, 15 parts, Radix Glycyrrhizae.
Chinese medical book and modern study result are merged in the present invention, sum up clinical experience, initiate " fever caused by exogenous pathogenic factors is controlled from wind opinion ", change and determine dispelling wind to relieve the exterior syndrome side.Herba Schizonepetae expelling pathogenic wind from the body surface in side and property is more gentle, Radix Saposhnikoviae expelling pathogenic wind from the body surface, slightly warm in nature, sweet slow high, Rhizoma Et Radix Notopterygii is not induced sweat cold expelling, wind-expelling pain-stopping, and three medicines are all monarch drug, expelling pathogenic wind from the body surface cold expelling, and the property of medicine is very not high strong; The pungent loose expelling pathogenic factors from muscles of Radix Bupleuri, Rhizoma Chuanxiong promoting the circulation of blood dispel the wind, and be ministerial drug altogether, principal drug assistance induces sweat and brings down a fever; The pungent loose expelling pathogenic factors from muscles of Radix Bupleuri, Rhizoma Chuanxiong promoting the circulation of blood dispel the wind, and be ministerial drug altogether, principal drug assistance induces sweat and brings down a fever; Make with Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.Full side coordinates, and plays the effect of expelling cold and relieving exterior syndrome, dispelling wind expelling pathogenic factors from muscles altogether.
According to embodiment, the preparation method of the compound Chinese medicinal preparation of the aforementioned antipyretic and anti-inflammatory of the present invention, comprises the steps:
(1) drop in nonmetallic vessel after eight taste crude drug being weighed, add the pure water of 1-3 times amount, stir, be heated to boiling, boil rear maintenance boiling a period of time, be separated fried liquid and medicinal residues;
(2) medicinal residues of (1) are added again the pure water of 1-3 times amount, be heated to boiling, boil rear maintenance boiling a period of time, be separated fried liquid and medicinal residues;
(3) mix twice fried liquid, the relative density fried liquid being concentrated into 80 DEG C is 1.04-1.10, standby clothes.The present invention's test example subsequently will prove: after rats by intraperitoneal injection LPS, and each period body temperature all obviously raises, and comparatively blank group comparing difference all has statistical significance (P < 0.01); After rats by intraperitoneal injection LPS, apply aspirin and " dispelling wind to relieve the exterior syndrome side " intervention respectively, aspirin group and each period body temperature of dispelling wind to relieve the exterior syndrome group rat all reduce, with model control group comparing difference, there is statistical significance (P < 0.01), dispelling wind to relieve the exterior syndrome group comparatively aspirin group rat refrigeration function onset is slower, but effect is more lasting, wherein the 4th hour dispelling wind to relieve the exterior syndrome group temperature decline comparatively aspirin group compare there is statistical significance (P < 0.05).After mice application aspirin and " dispelling wind to relieve the exterior syndrome side " intervene, abdominal cavity capillary permeability significantly reduces (P < 0.01), and aspirin and " dispelling wind to relieve the exterior syndrome side " intervene result difference without significance.After mice application dexamethasone and " dispelling wind to relieve the exterior syndrome side " intervene, auricle edema degree obviously reduces (P < 0.01), and dexamethasone and " dispelling wind to relieve the exterior syndrome side " intervene result difference without significance." dispelling wind to relieve the exterior syndrome side " has the pharmacological action of antipyretic and anti-inflammatory, and the clinical practice for the party provides certain theoretical basis.
Detailed description of the invention
Below in conjunction with specific embodiment, set forth the present invention further.These embodiments are interpreted as only being not used in for illustration of the present invention limiting the scope of the invention.After the content of having read the present invention's record, those skilled in the art can make various changes or modifications the present invention, and these equivalence changes and modification fall into the scope of the claims in the present invention equally.
Embodiment 1
Take Herba Schizonepetae 90 grams, Radix Saposhnikoviae 90 grams, Semen Sojae Preparatum 90 grams, the Radix Angelicae Dahuricae 90 grams, Rhizoma Chuanxiong 90 grams, Rhizoma Et Radix Notopterygii 90 grams, Radix Bupleuri 90 grams, 30 grams, Radix Glycyrrhizae.Include in nonmetallic vessel by this eight tastes Chinese medicine, add room temperature pure water 5000ml, soak 15 minutes after stirring, post-heating, to boiling, boils rear maintenance boiling 5 minutes, the fried liquid 1500ml of rear separation.Again add room temperature pure water 3000ml, be heated to boiling, boil rear maintenance boiling 3 minutes, be separated fried liquid 1500ml.Mix twice fried liquid, the relative density fried liquid being concentrated into 80 DEG C is 1.07, waits until standby clothes.
Embodiment 2
Take Herba Schizonepetae 30 grams, Radix Saposhnikoviae 30 grams, Semen Sojae Preparatum 30 grams, the Radix Angelicae Dahuricae 30 grams, Rhizoma Chuanxiong 30 grams, Rhizoma Et Radix Notopterygii 30 grams, Radix Bupleuri 60 grams, 30 grams, Radix Glycyrrhizae.Include in nonmetallic vessel by this eight tastes Chinese medicine, add room temperature pure water 500ml, soak 15 minutes after stirring, post-heating, to boiling, boils rear maintenance boiling 5 minutes, the fried liquid 150ml of rear separation.Again add room temperature pure water 300ml, be heated to boiling, boil rear maintenance boiling 3 minutes, be separated fried liquid 150ml.Mix twice fried liquid, the relative density fried liquid being concentrated into 80 DEG C is 1.04, waits until standby clothes.
Embodiment 3
Take Herba Schizonepetae 180 parts, Radix Saposhnikoviae 180 parts, Semen Sojae Preparatum 150 parts, the Radix Angelicae Dahuricae 120 parts, Rhizoma Chuanxiong 240 parts, Rhizoma Et Radix Notopterygii 150, Radix Bupleuri 300 parts, 150 parts, Radix Glycyrrhizae.Include in nonmetallic vessel by this eight tastes Chinese medicine, add room temperature pure water 4410ml, soak 15 minutes after stirring, post-heating, to boiling, boils rear maintenance boiling 5 minutes, the fried liquid 1500ml of rear separation.Again add room temperature pure water 3000ml, be heated to boiling, boil rear maintenance boiling 3 minutes, be separated fried liquid 1500ml.Mix twice fried liquid, the relative density fried liquid being concentrated into 80 DEG C is 1.10, waits until standby clothes.
Test example
Bring down a fever and antiinflammatory action in dispelling wind to relieve the exterior syndrome side, for dispelling wind to relieve the exterior syndrome side's treatment fever caused by exogenous pathogenic factors provides Basic Experiment Study foundation.Adopt intraperitoneal injection of LPS to cause rat fever method, observe expelling pathogenic wind from the body surface side's antipyretic effect; Adopt lumbar injection acetic acid to cause mouse peritoneal capillary permeability and increase method, observe expelling pathogenic wind from the body surface side and reduce inflammatory exudation effect; Adopt dimethylbenzene to smear and cause mice auricle swelling method, observe expelling pathogenic wind from the body surface side and reduce inflammatory swelling effect.
1, experiment material:
1.1 laboratory animal
Healthy SD rat, male and female half and half, 100-120g, SPF level, is provided by Shanghai Slac Experimental Animal Co., Ltd. totally by 50, animal quality certification numbering (2007000518592).
Kunming mouse, male and female half and half, 18-20g, SPF level, is provided by Shanghai Slac Experimental Animal Co., Ltd. totally by 60, animal quality certification numbering (2007000518382).
1.2 medicines and reagent
Expelling pathogenic wind from the body surface side's (concentration is 365g crude drug/L) that random selecting embodiment 1-3 is obtained, is produced by Longhua Hospital affiliated Shanghai University Of Chinese Traditional Medicine Drug Manufacturing Room and provides.
Dimethylbenzene (analytical pure), the prosperous chemical materials factory in Tianjin; Evans Blue, U.S. Sigma; Escherichia coli endotoxin (LPS), Chinese pharmaceutical biological product qualification institute; Aspirin tablet, Fuling Pharmaceutical Factory, Sichuan Prov; Dexamethasone acetate tablets, by Chinese Xinyi Pharmaceutical Factory.
1.3 experimental apparatus
FA2004B electronic balance (Shanghai Precision Scientific Apparatus Co., Ltd); J-301 High speed refrigerated centrifuge (Beckman, USA); UV-2102 type ultraviolet-uisible spectrophotometer (UNICO (Shanghai) Instrument Ltd.).
2, experimental technique:
The impact that 2.1 " dispelling wind to relieve the exterior syndrome sides " generate heat on LPS induced rat
Healthy SD rat, male and female half and half, 100-120g, SPF level, is provided by Shanghai Slac Experimental Animal Co., Ltd. totally by 50.Conventional adaptation is fed, and increase to after 250-300g until body weight, measure rat temperature (anus temperature) every day, continuous 2 days, the meansigma methods of getting 2 body temperature was designated as basal body temperature.Single body temperature more than 38 DEG C or 2 poor rats more than 0.5 DEG C of body temperature rejected.Be divided into blank group, model control group, dispelling wind to relieve the exterior syndrome group, aspirin group at random, often organize 10.Test front 6 h fast and can't help water, model group, Chinese drug-treated group, Western medicine group lumbar injection LPS(20ug/kg) bring out animal heating, give relative medicine gavage respectively, matched group lumbar injection and gavage such as to be at the dosage normal saline.Body temperature was surveyed 1 time every 1 hour, continuously monitoring 8 hours after modeling.
2.2 " dispelling wind to relieve the exterior syndrome sides " are on the impact of mice capillary permeability
Kunming mouse, male and female half and half, 18-22g, SPF level, is provided by Shanghai Slac Experimental Animal Co., Ltd. totally by 30.Adaptability is divided into matched group, dispelling wind to relieve the exterior syndrome group, aspirin group after feeding at random, often organizes 10.Give relative medicine gavage continuous 7 days, last administration is after 30 minutes, after tail vein injection 0.5% azovan blue liquid (0.1ml/10g), lumbar injection 0.6% acetic acid normal saline 0.2ml/ only immediately, animal is put to death after 20 minutes, abdominal scissors one osculum, abdominal cavity is washed for several times with 6mL normal saline, suction pipe sucking-off cleaning mixture, normal saline is added to 10mL after merging, 3000 rpms centrifugal 15 minutes, gets supernatant in spectrophotometer 590nm wavelength place colorimetric densitometric (Optical Density, OD) value.
The impact of 2.3 " dispelling wind to relieve the exterior syndrome side " xylol inducing mouse auricle edema
Kunming mouse, male and female half and half, 18-22g, SPF level, is provided by Shanghai Slac Experimental Animal Co., Ltd. totally by 30.Adaptability is divided into matched group, dispelling wind to relieve the exterior syndrome group, dexamethasone acetate group after feeding at random, often organizes 10.Give relative medicine gavage continuous 7 days, last administration is after 30 minutes, and by dimethylbenzene 0.1ml uniform application in mouse right ear auricle, left ear is blank.2 hours post-tensioning necks are put to death, and cut by left and right ear with the operation basal part of the ear of having one's hair trimmed, lay auricle with diameter 8mm card punch at the same position of left and right ear, analytical balance is weighed, and calculates the difference of auris dextra sheet and left auricle weight.
2.4 statistical method
Application SPSS11.5 statistical software carries out statistical analysis.Meet the measurement data of normal distribution with mean ± standard deviation
represent, between group, mean compares employing variance analysis.Power of test is with P < 0.05 for difference has significance, and P < 0.01 has very significant for difference.
3, experimental result:
The impact that 3.1 " dispelling wind to relieve the exterior syndrome sides " generate heat on LPS induced rat
As shown in table 1, after rats by intraperitoneal injection LPS, each period body temperature all obviously raises, and comparatively blank group comparing difference all has statistical significance (P < 0.01); After rats by intraperitoneal injection LPS, apply aspirin and " dispelling wind to relieve the exterior syndrome side " intervention respectively, aspirin group and each period body temperature of dispelling wind to relieve the exterior syndrome group rat all reduce, with model control group comparing difference, there is statistical significance (P < 0.01), dispelling wind to relieve the exterior syndrome group comparatively aspirin group rat refrigeration function onset is slower, but effect is more lasting, wherein the 4th hour dispelling wind to relieve the exterior syndrome group temperature decline comparatively aspirin group compare there is statistical significance (P < 0.05)
3.2 " dispelling wind to relieve the exterior syndrome sides " are on the impact of mice capillary permeability
Table 2. dispelling wind to relieve the exterior syndrome side is on the impact of mouse peritoneal capillary permeability
| Group | n | OD value |
| Matched group | 10 | 0.221±0.045 |
| Aspirin group | 10 | 0.162±0.053 ▲▲ |
| Dispelling wind to relieve the exterior syndrome group | 10 | 0.176±0.049 ▲▲ |
Note: compare with blank,
▲ ▲p < 0.01
As shown in table 2, after mice application aspirin and " dispelling wind to relieve the exterior syndrome side " intervene, abdominal cavity capillary permeability significantly reduces (P < 0.01), and aspirin and " dispelling wind to relieve the exterior syndrome side " intervene result difference without significance.
The impact of 3.3 " dispelling wind to relieve the exterior syndrome side " xylol inducing mouse auricle edema
The xylol induced mice auricle edema impact of table 3. dispelling wind to relieve the exterior syndrome side
| Group | n | Auricle weight difference (mg) |
| Matched group | 10 | 1.94±0.55 |
| Dexamethasone group | 10 | 1.18±0.40 ▲▲ |
| Dispelling wind to relieve the exterior syndrome group | 10 | 1.04±0.41 ▲▲ |
Note: compare with blank,
▲ ▲p < 0.01
As shown in table 3, after mice application dexamethasone and " dispelling wind to relieve the exterior syndrome side " intervene, auricle edema degree obviously reduces (P < 0.01), and dexamethasone and " dispelling wind to relieve the exterior syndrome side " intervene result difference without significance.
4, analysisanddiscusion:
Chinese medicine have accumulated rich experience in the treatment of fever caused by exogenous pathogenic factors, and " Plain Questions heat opinion " specially a section refers: " Jin Fure patient, all typhoid fever and so on also.”
"Nei Jing" is emphasized " drugs of hot nature are not contraindicated for diaphoresis ".Treatise on Febrile Diseases treatment exterior syndrome due to wind-cold, " wind is excessive to be won ancestor's "Nei Jing", flat with pungent, helps with hardship; Cold excessive in interior, control with sweet heat, help with arduous " method, fall apart it with pungent, send out it with temperature.Modern study confirms simultaneously, the generation of exterior syndrome is suffered from cold relevant with body usually, cold and cool stimulation is in respiratory mucosa, local vasoconstriction, ischemia, resistance is caused to decline, make the pathogen being originally present in upper respiratory tract seize the opportunity to worm one's way into mucomembranous epithelial cell growth and breeding, cause infective inflammation and occur various clinical symptoms
[wang Ruimin, Chen Yusheng, Su Baogang. opinion " drugs of hot nature are not contraindicated for diaphoresis " [J]. TCM investigation, 2006,19 (2): 9.
].And the non-specific immunity of pungent and warm medicine for relieving the exterior syndrome to body has more obvious facilitation, be conducive to the invasion and attack that body resists exopathogen
[zou Wenjun, Lei Zaiquan, Zhang Tingmo. the medicine law that induces sweat inquires into [J]. Chengdu University of Traditional Chinese Medicine's journal, 2001,24 (1): 7.
].
Short Term Clinical research shows, acute upper respiratory tract infection
[5 Luo Yi, Yan Xia, Li Jiqiang, analyze [J] etc. the acute upper respiratory tract infection 2502 routine Syndrome in TCM marquis that generate heat. Zhejiang Journal of Traditional Chinese Medicine, 2005,5:221-222.
]catch a cold with winter
[liu Qingquan, Jiang Liangduo. the feature that Beijing 2006-2007 catches a cold winter and Chinese medicine prevention strategy [J]. Beijing traditional Chinese medical science, 2007,26 (2): 70-71.
]in TCM syndrome, the exterior syndrome due to wind-cold being main symptom with heating, aversion to cold, head-body-pain, floating pulse, thin fur or from the beginning of time the person that has exterior syndrome due to wind-cold concurrently more than 70%, in distinguished veteran doctors of TCM treatment in present age acute upper respiratory tract infection dialectical process, diseases caused by exogenous pathogenic factor wind-cold syndrome occupies sizable ratio, and is Antiphlogistic Powder of Schizonepetae and Ledebouriellae for the maximum person in exterior syndrome due to wind-cold choosing side in medication
[luo Yi, Zheng Danwen, Li Jiqiang, etc. [J] is analyzed in the Coryza Treated by Syndrome Differentiation empirical statistics of contemporary distinguished veteran doctors of TCM treatment acute upper respiratory tract infection. Chinese Chinese medicine modern distance education, 2010,8 (17): 183-184.
].
Dispelling wind to relieve the exterior syndrome side for theoretical basis, foundes " the dispelling wind to relieve the exterior syndrome side " based on relieving the exterior syndrome with drugs of pungent in flavor and warm in nature with " fever caused by exogenous pathogenic factors is controlled from wind opinion ", and the party has effect of expelling cold and relieving exterior syndrome, dispelling wind expelling pathogenic factors from muscles.Herba Schizonepetae expelling pathogenic wind from the body surface in dispelling wind to relieve the exterior syndrome side and property is more gentle, Radix Saposhnikoviae expelling pathogenic wind from the body surface, slightly warm in nature, sweet slow high, Rhizoma Et Radix Notopterygii is not induced sweat cold expelling, wind-expelling pain-stopping, and three medicines are all monarch drug, expelling pathogenic wind from the body surface cold expelling, and the property of medicine is very not high strong; The pungent loose expelling pathogenic factors from muscles of Radix Bupleuri, Rhizoma Chuanxiong promoting the circulation of blood dispel the wind, and be ministerial drug altogether, principal drug assistance induces sweat and brings down a fever; The pungent loose expelling pathogenic factors from muscles of Radix Bupleuri, Rhizoma Chuanxiong promoting the circulation of blood dispel the wind, and be ministerial drug altogether, principal drug assistance induces sweat and brings down a fever; Make with Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.Full side coordinates, and plays the effect of expelling cold and relieving exterior syndrome, dispelling wind expelling pathogenic factors from muscles altogether.
6, experiment conclusion:
Experimental result shows, " dispelling wind to relieve the exterior syndrome side " has the pharmacological action of antipyretic and anti-inflammatory, and the present invention is that the clinical practice of dispelling wind to relieve the exterior syndrome side provides certain theoretical basis.
Claims (6)
1. a compound Chinese medicinal preparation for antipyretic and anti-inflammatory, is characterized in that, is made up of the crude drug of following weight portion: Herba Schizonepetae 3-18 part, Radix Saposhnikoviae 3-18 part, Semen Sojae Preparatum 3-15 part, Radix Angelicae Dahuricae 3-12 part, Rhizoma Chuanxiong 3-24 part, Rhizoma Et Radix Notopterygii 3-15, Radix Bupleuri 6-30 part, Radix Glycyrrhizae 3-15 part.
2. the compound Chinese medicinal preparation of antipyretic and anti-inflammatory according to claim 1, is characterized in that, the weight portion of crude drug is respectively: Herba Schizonepetae 9 parts, Radix Saposhnikoviae 9 parts, Semen Sojae Preparatum 9 parts, the Radix Angelicae Dahuricae 9 parts, Rhizoma Chuanxiong 9 parts, Rhizoma Et Radix Notopterygii 9 parts, Radix Bupleuri 9 parts, 3 parts, Radix Glycyrrhizae.
3. the compound Chinese medicinal preparation of antipyretic and anti-inflammatory according to claim 1, is characterized in that, the weight portion of crude drug is respectively: Herba Schizonepetae 3 parts, Radix Saposhnikoviae 3 parts, Semen Sojae Preparatum 3 parts, the Radix Angelicae Dahuricae 3 parts, Rhizoma Chuanxiong 3 parts, Rhizoma Et Radix Notopterygii 3, Radix Bupleuri 6 parts, 3 parts, Radix Glycyrrhizae.
4. the compound Chinese medicinal preparation of antipyretic and anti-inflammatory according to claim 1, is characterized in that, the weight portion of crude drug is respectively: Herba Schizonepetae 18 parts, Radix Saposhnikoviae 18 parts, Semen Sojae Preparatum 15 parts, the Radix Angelicae Dahuricae 12 parts, Rhizoma Chuanxiong 24 parts, Rhizoma Et Radix Notopterygii 15, Radix Bupleuri 30 parts, 15 parts, Radix Glycyrrhizae.
5. the preparation method of the compound Chinese medicinal preparation of the arbitrary described antipyretic and anti-inflammatory of claim 1-4, is characterized in that, comprise the steps:
(1) drop in nonmetallic vessel after eight taste crude drug being weighed, add the pure water of 1-3 times amount, stir, be heated to boiling, boil rear maintenance boiling, be separated fried liquid and medicinal residues;
(2) medicinal residues of (1) are added again the pure water of 1-3 times amount, be heated to boiling, boil rear maintenance boiling, be separated fried liquid and medicinal residues;
(3) mix twice fried liquid, the relative density fried liquid being concentrated into 80 DEG C is 1.04-1.10, standby clothes.
6. the arbitrary described purposes of compound Chinese medicinal preparation in the medicine preparing antipyretic and anti-inflammatory of claim 1-4.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1093581A (en) * | 1993-04-16 | 1994-10-19 | 刘永举 | The compound method of tea capable of preventing and curing cold |
| CN1110168A (en) * | 1994-04-07 | 1995-10-18 | 山东临清中药厂 | Powder for curing wind-cold type of common cold and preparing method thereof |
| CN1144662A (en) * | 1995-03-14 | 1997-03-12 | 黄国杰 | Medicament for treating rheum |
| CN1213544A (en) * | 1997-10-01 | 1999-04-14 | 陈跃龙 | Instant powder of laryngopharyngitis and its prepn. method |
| CN101559099A (en) * | 2008-04-15 | 2009-10-21 | 北京亚东生物制药有限公司 | Traditional Chinese medicine composition for curing wind cold and preparation method thereof |
| CN101628108A (en) * | 2009-07-31 | 2010-01-20 | 金华市人民医院 | Traditional Chinese medicinal granules for treating wind-cold evil and preparation method thereof |
-
2014
- 2014-04-09 CN CN201410139345.5A patent/CN104971092A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1093581A (en) * | 1993-04-16 | 1994-10-19 | 刘永举 | The compound method of tea capable of preventing and curing cold |
| CN1110168A (en) * | 1994-04-07 | 1995-10-18 | 山东临清中药厂 | Powder for curing wind-cold type of common cold and preparing method thereof |
| CN1144662A (en) * | 1995-03-14 | 1997-03-12 | 黄国杰 | Medicament for treating rheum |
| CN1213544A (en) * | 1997-10-01 | 1999-04-14 | 陈跃龙 | Instant powder of laryngopharyngitis and its prepn. method |
| CN101559099A (en) * | 2008-04-15 | 2009-10-21 | 北京亚东生物制药有限公司 | Traditional Chinese medicine composition for curing wind cold and preparation method thereof |
| CN101628108A (en) * | 2009-07-31 | 2010-01-20 | 金华市人民医院 | Traditional Chinese medicinal granules for treating wind-cold evil and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 国家药典委员会: "《中华人民共和国药典 2010年版第一部》", 5 June 2010, 中国医药科技出版社 * |
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