CN104958283A - Alkalescence skin mucosa cleaning and disinfecting composition and preparing method and application thereof - Google Patents
Alkalescence skin mucosa cleaning and disinfecting composition and preparing method and application thereof Download PDFInfo
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- CN104958283A CN104958283A CN201510296671.1A CN201510296671A CN104958283A CN 104958283 A CN104958283 A CN 104958283A CN 201510296671 A CN201510296671 A CN 201510296671A CN 104958283 A CN104958283 A CN 104958283A
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Abstract
The invention provides an alkalescence skin mucosa cleaning and disinfecting composition and a preparing method thereof. The alkalescence skin mucosa cleaning and disinfecting composition is prepared in the manner that didecyl dimethyl ammonium chloride, dodecyl dimethyl benzyl ammonium chloride, dodecyl dimethyl benzyl ammonium oxide and glucoside are dissolved into purification water according to a certain proportion. The composition can be used for cleaning and disinfecting wounds, and therefore the composition can be conveniently used for wound emergency treatment in time.
Description
Technical field
The present invention relates to a kind of by animal grab bite after the skin wound disinfectant of rinsing, particularly by the compositions for wound irrigation and sterilization after dog bite, in addition, the invention still further relates to manufacture method and the purposes of disinfectant.
Background technology
Rabies are a kind of Arbo infectious disease caused by rabies virus, and the source of infection is mainly rabies host animal: dog, cat, wolf, Vulpes etc.China has been that since the 1950's, three peaks of rubies epidemiology have appearred in China, die from rabic number in recent years every year all more than 2400 people, are only second to India, occupy the whole world second by one of rabies harm country the most serious.
Rabies can anti-uncurable disease, and " rabies exposure prevention and disposition specification (2009 editions) " (specify hereinafter referred to as " specification ": what be judged to be that II level and III level expose by doctor after rabies exposure should carry out treatment of wounds, inoculation rabies vaccine and passive immunity preparation immediately.Treatment of wounds comprises cleaning down and disinfecting, wound irrigation should with 20% suds (or alkalescence cleaning agent) and a large amount of clear water alternately rinse all more than 15 minutes, places of scratching and bite.
But in above-mentioned " specification ", the suds (or alkalescence cleaning agent) of 20% are not easy to configure and are not the medical products of standard, and can not be used for skin and mucous membrane disinfection.Therefore, the compositions of cleaning in time, disinfecting of scratching to dog and bite also is not had at present.
Summary of the invention
In order to solve the problem, invention has been further investigation, find to have can clean and the ability of wound of sterilizing simultaneously by DDAC, dodecyl dimethyl benzyl ammonium chloride, dodecayl dimethyl amine oxide and glucoside being dissolved in the alkalescence compositions prepared in purified water, therefore, said composition can facilitate, in time for wound emergency processing, thus complete the present invention.
Particularly, the present invention relates to following content.
In a first aspect of the present invention, provide a kind of alkalescence mucocutaneous cleaning and sanitizing composition, it is made up of following material:
Preferably, in the mucocutaneous cleaning and sanitizing composition of alkalescence of the present invention, in the quaternary ammonium salt content of benzalkonium chloride in the scope of 1.00-1.20g/L.
Further preferably, the pH value of the mucocutaneous cleaning and sanitizing composition of alkalescence of the present invention is within the scope of 7.2-7.5.
In another aspect of this invention, the manufacture method of the mucocutaneous cleaning and sanitizing composition of above-mentioned alkalescence is provided, comprising by DDAC, dodecyl dimethyl benzyl ammonium chloride, dodecayl dimethyl amine oxide and glucoside are as raw material simultaneously or be dissolved in successively in purified water, to make the percentage by weight of DDAC for 0.050-0.060%, the percentage by weight of dodecyl dimethyl benzyl ammonium chloride is 0.030-0.040%, the percentage by weight of dodecayl dimethyl amine oxide is the percentage by weight of 1.5-2.5% and glucoside is the step of 1.5-2.5%.
The mucocutaneous cleaning and sanitizing composition of alkalescence of the present invention has the dual-use function of cleaning agent and disinfectant, is applicable to the wound surface after rabies exposure especially and rinses.The requirement that said composition meets completely " specification ".The product produced thus through authoritative institution's checking, has obtained sterile products and to have put on record code.
By explaining following the preferred embodiments of the invention, other objects of the present invention and advantage will become clear.
Detailed description of the invention
Except the present invention separately explains, otherwise the noun used in the application, term, phrase have common implication in this area.In addition, except the present invention separately has regulation, otherwise the reagent used in the application, instrument etc. are conventional reagent in this area or instrument, and they can commercially freely obtain.In addition, unless otherwise indicated, otherwise the content of material described in the application, percentage ratio all based on weight.
" alkalescence " described in the application refers to that pH value is the character of 7.2-7.5.Weakly alkaline requirement during solution in this pH value range meets " rabies exposure prevention and disposition specification (2009 editions) ".Wherein the measurement of pH value can adopt any method known in the art to carry out.
Quaternary ammonium salt content described in the application is the amount after being scaled benzalkonium chloride, and its content is 1.00-1.20g/L, is preferably 1.09g/L.If content is outside above-mentioned scope, then can cause the change of pH value range, thus adversely affect effect of the present invention.Such as, skin can be made to have excitement when causing pH value too high.In order to the content reaching quaternary ammonium salt is 1.00-1.20g/L, the percentage by weight of DDAC preferably can be made to be 0.050-0.060%, the percentage by weight of dodecyl dimethyl benzyl ammonium chloride is 0.030-0.040%, and the percentage by weight of dodecayl dimethyl amine oxide is 1.5-2.5%.
The content of " glucoside " described in the application, what the gross weight based on compositions can be good within the scope of 1.5-2.5% realizes flushing of the present invention, Disinfection Effect, is 2.0% from the content of the preferred glucoside of angle embodying above-mentioned effect further.
" cleaning and sanitizing composition " described in the application refers to and meets " rabies exposure prevention and disposition specification (2009 editions) " for the compositions of wound irrigation with the regulation of disinfecting.Wherein compositions can adopt any form, as the form of cleaning agent.Preferably, described compositions is colourless solution form, and particularly preferably described compositions is the form of colourless aqueous solution.
Compositions described in the application can be used for processing any wound, such as, scratch, abrade, bite, any type of wound with skin injury such as cold injury.Particularly preferably be the process of lyssodexis mouth.Most preferably be judged to be by doctor the wound that II level and III level expose after rabies exposure.
Describe the present invention in detail below by way of concrete preferred embodiment, but the present invention is not limited thereto.
The preparation of embodiment 1 cleaning and sanitizing composition
Raw material according to following table 1 and composition prepare cleaning and sanitizing composition 1 of the present invention.
The formula of table 1 cleaning and sanitizing composition 1
Utilize each raw material of the DDAC in table 1, dodecyl dimethyl benzyl ammonium chloride, dodecayl dimethyl amine oxide and glucoside, prepared cleaning and sanitizing composition 2-5 and the comparative composition 1-4 of each content composition shown in following table 2 by the dosage changing each raw material respectively.
The formula of table 2 cleaning and sanitizing composition 2-5 and comparative composition 1-4
Note: in compositions, the content of each composition is the percentage composition (%) based on weight, and total amount is 100%.
The inspection of each compositions of embodiment 2
Get above-mentioned each compositions 250ml/ bottle × 15 bottle, according to " disinfection technology standard " (version in 2002), GB26369-2010 " quaternary ammonium disinfectant sanitary standard ", GB27951-2011 " skin antiseptic hygienic requirements " and GB27954-2011 " mucosa disinfectant General Requirement " etc., the character of cleaning and sanitizing composition of the present invention and each comparative composition is tested.Concrete outcome is as follows:
The character of table 3 cleaning and sanitizing composition and each comparative composition
Note:
1. quaternary ammonium salt (in benzalkonium chloride, g/L) assay: according to GB 26369-2010 " quaternary ammonium disinfectant sanitary standard ", measure under 25 DEG C of 45% relative humidity.Measured value is the meansigma methods of same sample twice measured value.
2.pH pH-value determination pH: carry out according to " disinfection technology standard " version 2.2.1.4pH pH-value determination pH in 2002.Instrument and equipment: PHS-25 type precision acidity meter (numbering 107).Correction buffer: Potassium Hydrogen Phthalate buffer (pH value 4.00,25 DEG C), phosphate buffer (pH value 6.86,25 DEG C), sodium tetraborate buffer (pH value 9.18,25 DEG C), from Shanghai Lei Cichuanyi instrumentation table company limited.
3. the mensuration of rate of descent (54 DEG C, 14 days) and rate of descent (37 DEG C, 3 months): measure according to GB26369-2010 " quaternary ammonium disinfectant sanitary standard ", sample replication twice, results averaged.
4. heavy metal limit " qualified ": refer to the regulation meeting GB27951-2011 " skin antiseptic hygienic requirements " and GB27954-2011 " mucosa sterilization General Requirement ".
5. the mensuration of the logarithm value that sterilizes: test according to " disinfection technology standard " (version in 2002).
6. many intact skin irritant tests and a damaged skin irritant test: test according to " disinfection technology standard " (version in 2002).
7. acute eye irritation test: carry out according to " disinfection technology standard " (version in 2002) 2.3.4 acute eye irritation test.
8. subacute toxicity test: carry out according to " disinfection technology standard " (version in 2002) 2.3.7 item subacute toxicity test.
Can obviously be found out by the result of table 3, the cleaning and sanitizing composition of the application has effective kill oncomelania (that is, being greater than the value of 5.0), irritant reaction be there is no for skin simultaneously, and have good stability, therefore, have as cleaning and the ability of wound of sterilizing simultaneously.On the contrary, comparative composition 1-3 or poor stability, or bactericidal effect is poor, or for skin etc., there is stimulation, therefore, well can not be applied to wound, particularly the process of the wound such as lyssodexis.
More than in conjunction with detailed description of the invention and exemplary example to invention has been detailed description, but these explanations can not be interpreted as limitation of the present invention.It will be appreciated by those skilled in the art that when not departing from spirit and scope of the invention, can carry out multiple equivalencing, modification or improvement to technical solution of the present invention and embodiment thereof, these all fall within the scope of the present invention.Protection scope of the present invention is as the criterion with claims.
Claims (10)
1. the mucocutaneous cleaning and sanitizing composition of alkalescence, it is made up of following material:
2. cleaning and sanitizing composition according to claim 1, wherein based on the cumulative volume of compositions, in the quaternary ammonium salt content of benzalkonium chloride in the scope of 1.00-1.20g/L.
3. cleaning and sanitizing composition according to claim 1 and 2, its pH value is within the scope of 7.2-7.5.
4. cleaning and sanitizing composition according to claim 1 and 2, wherein said DDAC is 0.054% based on the percentage ratio of composition total weight.
5. cleaning and sanitizing composition according to claim 1 and 2, wherein said dodecyl dimethyl benzyl ammonium chloride is 0.036% based on the percentage ratio of composition total weight.
6. cleaning and sanitizing composition according to claim 1 and 2, wherein said dodecayl dimethyl amine oxide is 2.0% based on the percentage ratio of composition total weight.
7. cleaning and sanitizing composition according to claim 1 and 2, wherein said glucoside is 2.0% based on the percentage ratio of composition total weight.
8. manufacture a method for the mucocutaneous cleaning and sanitizing composition of alkalescence according to any one of claim 1-7, comprising using DDAC, dodecyl dimethyl benzyl ammonium chloride, dodecayl dimethyl amine oxide and glucoside as raw material simultaneously or the step be dissolved in successively in purified water.
9. the mucocutaneous cleaning and sanitizing composition of the alkalescence according to any one of claim 1-7 is preparing purposes in wound irrigation compositions.
10. purposes according to claim 9, wherein said wound is lyssodexis mouth.
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| CN201510296671.1A CN104958283A (en) | 2015-06-02 | 2015-06-02 | Alkalescence skin mucosa cleaning and disinfecting composition and preparing method and application thereof |
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Cited By (7)
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| CN106727849A (en) * | 2017-01-22 | 2017-05-31 | 李忠泽 | A kind of gynecological gel |
| CN107050105A (en) * | 2017-02-24 | 2017-08-18 | 李忠泽 | A kind of antiseptic |
| CN107412157A (en) * | 2017-09-20 | 2017-12-01 | 四川医平医疗管理有限公司 | Wound disinfection cleaning combination |
| CN109200343A (en) * | 2018-08-29 | 2019-01-15 | 杨帆 | A kind of sterilization spermicidal lubricant suitable for vagina |
| CN109316536A (en) * | 2018-10-22 | 2019-02-12 | 湖南中威制药有限公司 | A kind of skin mucosa disinfecting agent and preparation method thereof |
| WO2019197782A1 (en) * | 2018-04-11 | 2019-10-17 | Eurochem | Dermatological composition facilitating skin repair |
| CN111956728A (en) * | 2020-07-15 | 2020-11-20 | 湖北华冠中科生物药业有限公司 | Alkalescent skin mucosa cleaning disinfectant and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106727849A (en) * | 2017-01-22 | 2017-05-31 | 李忠泽 | A kind of gynecological gel |
| CN107050105A (en) * | 2017-02-24 | 2017-08-18 | 李忠泽 | A kind of antiseptic |
| CN107412157A (en) * | 2017-09-20 | 2017-12-01 | 四川医平医疗管理有限公司 | Wound disinfection cleaning combination |
| WO2019197782A1 (en) * | 2018-04-11 | 2019-10-17 | Eurochem | Dermatological composition facilitating skin repair |
| FR3080003A1 (en) * | 2018-04-11 | 2019-10-18 | Eurochem | DERMATOLOGICAL COMPOSITION FACILITATING SKIN REPAIR |
| CN109200343A (en) * | 2018-08-29 | 2019-01-15 | 杨帆 | A kind of sterilization spermicidal lubricant suitable for vagina |
| CN109316536A (en) * | 2018-10-22 | 2019-02-12 | 湖南中威制药有限公司 | A kind of skin mucosa disinfecting agent and preparation method thereof |
| CN111956728A (en) * | 2020-07-15 | 2020-11-20 | 湖北华冠中科生物药业有限公司 | Alkalescent skin mucosa cleaning disinfectant and preparation method thereof |
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