CN104888875B - Based on the movable micro-fluidic chip of the lower wall surface specified location of microchannel - Google Patents
Based on the movable micro-fluidic chip of the lower wall surface specified location of microchannel Download PDFInfo
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- CN104888875B CN104888875B CN201510379947.2A CN201510379947A CN104888875B CN 104888875 B CN104888875 B CN 104888875B CN 201510379947 A CN201510379947 A CN 201510379947A CN 104888875 B CN104888875 B CN 104888875B
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- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims abstract description 32
- 239000012528 membrane Substances 0.000 claims abstract description 20
- 239000007787 solid Substances 0.000 claims abstract description 19
- 239000007788 liquid Substances 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 13
- 230000000694 effects Effects 0.000 claims description 9
- 230000015572 biosynthetic process Effects 0.000 claims description 8
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 8
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 4
- 238000005452 bending Methods 0.000 claims description 3
- 239000011521 glass Substances 0.000 claims description 3
- 239000010409 thin film Substances 0.000 claims description 3
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims 2
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims 2
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims 2
- 230000000007 visual effect Effects 0.000 abstract 1
- 238000011160 research Methods 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000011161 development Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000010408 film Substances 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- -1 polydimethylsiloxane Polymers 0.000 description 2
- 235000007926 Craterellus fallax Nutrition 0.000 description 1
- 240000007175 Datura inoxia Species 0.000 description 1
- 238000011953 bioanalysis Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 238000002032 lab-on-a-chip Methods 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000001259 photo etching Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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Abstract
Based on the movable micro-fluidic chip of the lower wall surface specified location of microchannel, base-plate holes are the groove structure of the upper surface being arranged on pedestal, and it determines the positions and dimensions of deformable segment in the lower surface of microchannel；The bottom of pedestal is microscope slide, and main body solid structure is arranged on pedestal；It is provided with membrane structure between pedestal and main body solid structure；The two ends of main channel are respectively continuous phase entrance, outlet；The side of main channel is connected with wing passage, and the end of wing passage is discrete phase entrance；The present invention can not increase extra drive or control device on the basis of, generate the preferable microscale droplets of conventional microfluidic control chip inaccessiable uniformity under the conditions of identical flowing using simple MCA, visual and clear, simple to operate.
Description
Technical field
The present invention relates to a kind of micro-fluidic chip movable based on the lower wall surface specified location of microchannel, do not applying additionally
On the basis of driving means and control device, by adjusting the positions and dimensions of moving part, the flowing shape of impact channel interior
Condition, thus adjust the generation of bubble.
Background technology
With greatly developing of small scalization or bio-analysis system, it is related to micro-total analysis system (micro total
Analysis ayatems, μ TAS) or various types of microfluidic device of chip lab (lab-on-a-chip) extensive
Design and studying, the research with regard to Micro-flows obtains achievement compared with horn of plenty, and defines some pins on this basis
The fluidal texture being commonly recognized to different application.
The high development of minute yardstick manufacturing technology at this stage also provides sufficiently for the research and application of Micro-flows
The technology such as technical support, such as photoetching and laser ablation are capable of making of micron scale construction etc., process for treating surface
Development can improve the precision of micro-fluidic device, can be converted into into from design with control structure based on this various new flowing
Product manufacture.
In studying in biological or chemical, single microlayer model can as independent chemical reaction, transport and mixture,
And it important function of emulsion process in industry such as manufactures in food and medicine, increasing concern is concentrated on and is based on by people
Come above the microscale droplets of microfluidic system.The current research with regard to microlayer model focuses primarily upon impact drop formation and crushes
The research of each factor of process, and obtained the ultimate principle of the breakup of drop, droplet size some Empirical rules relational expressions with
And each influence factor is for the interactively etc. of droplet size.
Although on the theoretical basis with the development of microflow control technique of Micro-flows, the research with regard to microlayer model obtains
The result much widely received by researcheres, but inhomogeneities during drop is produced and control it uneven
The problems such as method of even property shorter mention.
Content of the invention
The present invention is based on conventional microlayer model/bubble formation structure microchannel, (will be micro- logical by changing its wall type
The specified location of road bottom surface is instead able to the elastic wall deforming), improve, to reach, the purpose adjusting bubble formation effect.This
The specified location in the bottom surface of conventional T-shaped micro-channel chip for the invention, makes formation deformable thin much smaller than channel width
Membrane structure, is deformed and vibrates in the presence of the liquid that thin film can flow in passage.Experimental result shows, identical flowing
Under the conditions of, the microchannel with Thin Elastic wall structure can substantially adjust the size generating bubble and generation time.
Microchannel of the present invention, on the basis of conventional microscale channel, changes to the structure in channel wall face
Enter, primary structure is as follows：
Elastic bottom surface micro-channel chip comprise discrete phase entrance 1, wing passage 2, continuous phase entrance 3, main channel 4, outlet 5,
Main body solid structure 6, membrane structure 7, pedestal 8, microscope slide 9, base-plate holes 10；Wherein discrete phase entrance 1, wing passage 2, continuous
Phase entrance 3, main channel 4, outlet 5 are groove or hole structure on main body solid structure 6, are flow of fluids during chip operation
Region；
Base-plate holes 10 are the groove structure of the upper surface being arranged on pedestal 8, and it determines deformable in the lower surface of microchannel
Partial positions and dimensions；The bottom of pedestal 8 is microscope slide 9, and main body solid structure 6 is arranged on pedestal 8；Pedestal 8 and main body
It is provided with membrane structure 7 between solid structure 6；The two ends of main channel 4 are respectively continuous phase entrance 3, outlet 5；The side of main channel 4
Face is connected with wing passage 2, and the end of wing passage 2 is discrete phase entrance 1；
Main body solid structure 6, membrane structure 7, pedestal 8 are made up of PDMS (polydimethylsiloxane) material, carry
Slide 9 is conventional glass film-making.Conventional microscale channel does not comprise membrane structure 7 and pedestal 8, the work of membrane structure 7 and pedestal 8
With being to form lower wall surface designated area for deformable elastic film, provide structural support and deformation space for deformation.
The specific work process of this device is as follows：Gas flows into from discrete phase entrance 1, and continuous phase liquid is from continuous phase entrance
3 inflows, both cross in the junction of wing passage 2 and main channel 4, and discrete phase gas breaking forms bubble and with continuous phase
Toward downstream flow, eventually through outlet 5 outflow chip.During flowing, because PDMS material has elasticity in itself, and
Membrane structure 7 at base-plate holes 10 has the space of less bending rigidity and deformation so that membrane structure 7 is in liquid
Deform under effect and vibrate, and then affect the flowing of liquid and the generating process of bubble.
The present invention can be entered by making deformable elastic wall, impact liquid flowing in microchannel bottom designated area
And reach the effect adjusting bubble formation.
Brief description
Fig. 1 is the three-dimensional overall wheel based on the movable micro-fluidic chip of the lower wall surface specified location of T-shaped microchannel for the present invention
Wide schematic diagram.
Fig. 2 is the present invention based on deformable wall in the movable micro-fluidic chip of the lower wall surface specified location of T-shaped microchannel
Partial cross-sectional view.
Fig. 3 is the main channel section cross-sectional view of conventional T-shaped microchannel fluidic chip in contrast experiment.
Fig. 4 is that T-shaped microchannel micro-fluidic chip is used for realizing the work process schematic diagram of bubble formation.
In figure：1st, discrete phase entrance, 2, wing passage, 3, continuous phase entrance, 4, main channel, 5, outlet, 6, main body solid knot
Structure, 7, film bas structure, 8, pedestal, 9, microscope slide, 10, base-plate holes.
Note：Because microchannel size is much smaller than chip size, being represented during micro-fluidic chip with actual size can not clear table
Levy the structure of micro-fluidic chip runner section, therefore accompanying drawing uses the chip schematic diagram that micro-channel structure is amplified relatively.
Specific embodiment
With reference to Structure Figure to invention based on the movable micro-fluidic chip of the lower wall surface specified location of T-shaped microchannel
Work process and action effect are described in detail.
Elastic bottom surface T-shaped micro-channel chip comprises discrete phase entrance 1, wing passage 2, continuous phase entrance 3, main channel 4, outlet
5th, main body solid structure 6, membrane structure 7, pedestal 8, microscope slide 9, base-plate holes 10；Wherein discrete phase entrance 1, wing passage 2, company
Continuous phase entrance 3, main channel 4, outlet 5 are groove or hole structure on main body solid structure 6, are fluid streams during chip operation
Dynamic region；
Base-plate holes 10 are the groove structure of the upper surface being arranged on pedestal 8, and it determines variable in the lower surface of T-shaped microchannel
The positions and dimensions of shape part；The bottom of pedestal 8 is microscope slide 9, and main body solid structure 6 is arranged on pedestal 8；Pedestal 8 and master
It is provided with membrane structure 7 between body solid structure 6；The two ends of main channel 4 are respectively continuous phase entrance 3, outlet 5；Main channel 4
Side is connected with wing passage 2, and the end of wing passage 2 is discrete phase entrance 1；
Main body solid structure 6, membrane structure 7, pedestal 8 are made up of PDMS (polydimethylsiloxane) material, carry
Slide 9 is conventional glass film-making.Conventional T-shaped microscale channel does not comprise membrane structure 7 and pedestal 8, membrane structure 7 and pedestal 8
Effect be that to form lower wall surface designated area be deformable elastic film, provide structural support and deformation space for deformation.
The specific work process of this device is as follows：Gas flows into from discrete phase entrance 1, and continuous phase liquid is from continuous phase entrance
3 inflows, both cross in the junction of wing passage 2 and main channel 4, and discrete phase gas breaking forms bubble and with continuous phase
Toward downstream flow, eventually through outlet 5 outflow chip.During flowing, because PDMS material has elasticity in itself, and
Membrane structure 7 at base-plate holes 10 has the space of less bending rigidity and deformation so that membrane structure 7 is in liquid
Deform under effect and vibrate, and then affect the flowing of liquid and the generating process of bubble.
Fig. 1 is the three-dimensional overall outline drawing of the movable micro-fluidic chip of lower wall surface specified location based on T-shaped microchannel.
This chip comprises discrete phase entrance 1, wing passage 2, continuous phase entrance 3, main channel 4, outlet 5, main body solid structure 6, thin film knot
Structure 7, pedestal 8, microscope slide 9, base-plate holes 10.Fig. 4 is that the lower wall surface specified location movable surface based on T-shaped microchannel for the present invention is micro-
The work process schematic diagram of fluidic chip.Two kinds of fluids are flowed in micro-fluidic chip by two entrances under external force driving, adjust
The flox condition of whole two kinds of liquid is so as to generate microbubble, and keeps this flow velocity to make flowing stable for a period of time, then carries out liquid
Drip and generate record experiment.In order to verify the useful effect for bubble formation for this invention, can not be become using mutually isostructural bottom surface
The conventional microfluidic control chip of shape has carried out contrast experiment.The Air Bubble Size of two groups of experiments is as shown in table 1 it is seen that the present invention can have
Significantly affect the generation of bubble.
Table 1 chip of the present invention and the bubble length result contrasting chip
Note：Continuous phase flow velocity is 3 μ L/min, and the wing passage width of microchannel used is 300 μm, and main channel width is 300 μ
M, channel height is 100 μm.
Claims (1)
1. based on the movable micro-fluidic chip of the lower wall surface specified location of microchannel it is characterised in that：Elastic bottom surface microchannel core
Piece comprises discrete phase entrance (1), wing passage (2), continuous phase entrance (3), main channel (4), outlet (5), main body solid structure
(6), membrane structure (7), pedestal (8), microscope slide (9), base-plate holes (10)；Wherein discrete phase entrance (1), wing passage (2), company
Continuous phase entrance (3), main channel (4), outlet (5) are groove or hole structure on main body solid structure (6), are chip operations
When flow of fluid region；
Base-plate holes (10) are the groove structure of the upper surface being arranged on pedestal (8), and it determines deformable in the lower surface of microchannel
Partial positions and dimensions；The bottom of pedestal (8) is microscope slide (9), and main body solid structure (6) is arranged on pedestal (8)；Pedestal
(8) it is provided with membrane structure (7) and main body solid structure (6) between；The two ends of main channel (4) be respectively continuous phase entrance (3),
Outlet (5)；The side of main channel (4) is connected with wing passage (2), and the end of wing passage (2) is discrete phase entrance (1)；
Main body solid structure (6), membrane structure (7), pedestal (8) are made up of PDMS material, and microscope slide (9) is conventional glass system
Piece；The specific work process of this device is as follows, and gas flows into from discrete phase entrance (1), and continuous phase liquid is from continuous phase entrance (3)
Flow into, both cross in the junction of wing passage (2) and main channel (4), discrete phase gas breaking forms bubble and with continuous phase
Together toward downstream flow, flow out chip eventually through outlet (5)；During flowing, because PDMS material has bullet in itself
Property, and the membrane structure (7) at base-plate holes (10) place has the space of less bending rigidity and deformation so that thin film
Structure (7) deforms under liquid effects and vibrates, and then affects the flowing of liquid and the generating process of bubble；
This structure is passed through to make deformable elastic wall, impact liquid flowing in microchannel bottom designated area, and then reaches tune
The effect of section bubble formation.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510379947.2A CN104888875B (en) | 2015-07-01 | 2015-07-01 | Based on the movable micro-fluidic chip of the lower wall surface specified location of microchannel |
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| CN201510379947.2A CN104888875B (en) | 2015-07-01 | 2015-07-01 | Based on the movable micro-fluidic chip of the lower wall surface specified location of microchannel |
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| CN104888875B true CN104888875B (en) | 2017-03-01 |
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| CN105214746B (en) * | 2015-10-28 | 2017-08-11 | 北京工业大学 | The movable micro-fluidic chip of channel side wall specified location |
| CN106391152B (en) * | 2016-09-20 | 2018-07-31 | 北京工业大学 | The two deformable micro-fluidic chips in wall surface designated position above and below channel |
| CN106334589B (en) * | 2016-10-13 | 2017-07-28 | 中国石油大学(华东) | The micro-fluidic chip of organic solvent pollution in simulated groundwater system |
| CN106824674B (en) * | 2016-12-28 | 2019-12-13 | 浙江天宏机械有限公司 | Liquid-separating and glue-dispensing method based on micro-fluidic chip |
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| CN106733458B (en) * | 2016-12-28 | 2019-07-09 | 浙江达普生物科技有限公司 | A kind of glue dispensing valve based on micro-fluidic chip |
| CN106908397B (en) * | 2017-01-04 | 2019-04-30 | 浙江大学宁波理工学院 | Integrated optics biochemical sensitive chip and preparation method thereof based on limited drop resonance |
| CN108628351B (en) * | 2017-03-17 | 2021-11-09 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Microfluidic droplet generation device |
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| CN113368918B (en) * | 2021-06-21 | 2022-04-26 | 合肥瀚海星点生物科技有限公司 | Multi-channel liquid separation device and method based on microfluidic printing |
| CN114526373A (en) * | 2022-01-06 | 2022-05-24 | 北京大学 | Single-layer micro-fluidic pneumatic micro-valve and micro-fluidic chip |
| CN114950584B (en) * | 2022-04-27 | 2023-07-07 | 厦门大学 | Three-dimensional micro-channel chip structure for generating liquid drops and manufacturing method |
| US20240278230A1 (en) * | 2022-05-13 | 2024-08-22 | Boe Technology Group Co., Ltd. | Microfluidic chip, droplet generation device and method for controlling droplet generation size |
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| JP4721227B2 (en) * | 2006-05-22 | 2011-07-13 | アイダエンジニアリング株式会社 | Microchannel chip and manufacturing method thereof |
| CN102500435A (en) * | 2011-09-26 | 2012-06-20 | 北京大学 | Microfluidic chip capable of being used for enzyme-linked immunoassay |
| CN103894248B (en) * | 2014-04-09 | 2015-09-16 | 国家纳米科学中心 | A kind of single cell analysis micro-fluidic chip and system and single cell analysis method |
| CN104084247B (en) * | 2014-06-30 | 2017-02-08 | 北京工业大学 | Elastic wall surface micro-fluidic chip based on T-shaped micro-channel |
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