CN104887890A - Medicine composition for treating white scour of chicken and preparation method thereof - Google Patents
Medicine composition for treating white scour of chicken and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine composition for treating white scour of chicken and a preparation method thereof. The medicine composition comprises the following crude drugs: pulsatilla chinensis, phellodendron amurense, potentilla discolor, poria cocos, polygonum hydropiper, radix sophorae flavescentis, viola philippica, goldencup hypericum, herba pteridis multifidae, flos chrysanthemi indici, herba andrographitis, cuscuta chinensis, geranium maculatum, cirsium japonicum, medicated leaven, forrest cranesbill root, rhizoma atractylodis, callicarpa bodinieri, herba agrimoniae, acalypha australis, taraxacum officinale, pueraria lobata, capsella bursapastoris herba, caulis lonicerae, indigo naturalis, cacumen platycladi, rhizoma atractylodis macrocephalae, herba euphorbiae humifusae and semen arecae. The medicine composition for treating white scour of chicken provided by the invention has the benefits as follows: the medicine composition has the efficacies of invigorating the spleen, removing dampness, clearing away heat and toxic materials, cooling blood and inhibiting dysentery, and can regulate yang blood and qi of chicken, is high in cure rate, short in treatment course, low in amount of drug residue, and at the same time, can improve the immunity and disease resistance of chicken.
Description
Technical field
The present invention relates to field of veterinary, particularly a kind of pharmaceutical composition for the treatment of the white scour of chicken and preparation method thereof.
Background technology
Pullorum Disease is the infectious disease caused by S. pullonum, all has generation all over the world, is one of disease that harm poultry husbandry is the most serious.Primary disease is a kind of extremely common infectious disease, and its Excreta is important communication media, simultaneously also by egg vertical transmission.Main infringement chickling take Hakuri as feature, the ill rear many mortalities in two weeks of chickling.Primary disease is often widely current all over the world, forms serious threat to the development of poultry husbandry.
The cause of disease of this disease is Salmonella, is Gram-negative, is the elongated bacillus that two ends are slightly round, without pod membrane and brood cell, also atrichia, can not moves.Comparatively strong to the resistance of environment, temperature 5 DEG C-8 DEG C, can survive on wooden feed trough 65.Can be survived summer 20-35 days in soil.Winter can survive 128-184 day.Can survive more than 3 months at chicken manure suspension, the antibacterial on attachment fine hair can survive about 1 year.Adhere to antibacterial on chorion through 5 days, can be dead through 3 days in couveuse.Bacterial reproduction in 20 DEG C of egg yolks stored is very fast.The fowl of different cultivars all has infectivity, and susceptible degree and age, kind are relevant, and chickling is popular the most extensive, and the chicken M & M within 2 week age is all high.Along with the increase of age in days, the resistance of chicken also strengthens thereupon.Susceptibility between each kind of chicken has significant difference, and the chicken producing brown shell egg is more responsive than the chicken producing white shell egg, within after infecting 3-10 days, produces antibody.
Sick chicken and the chicken that carries disease germs are major source of infection, both can horizontal transmission, also can vertical transmission.Egg-part that positive chicken produces can possess this bacterium, and major part protects embryo's dead or stasi in hatching midway of bacterium egg, and small part can send up bacterium state and hatch.But majority is fallen ill soon going out shell.Sick young Excreta and secretions pollute feedstuff, drinking-water and apparatus, and same group chickling can be made infected, infect chickling most dead, but some sends up bacterium state, to when laying eggs again output protect bacterium egg, form repeated infection, circulation morbidity, makes epidemic disease be handed down from age to age.During cock copulation, also can by germina infection to hen.In addition, fly, Passeris montani saturati are also Vector of infection.The feeding and management of chickling is bad, temperature is fluctuated, raises hypotrophy, long-distance transport etc.Primary disease happening and prevelence and mortality rate all can be impelled to increase.
The clinical manifestation of Pullorum Disease: generation and the clinical manifestation of the white diarrhea disease of different days have larger difference, it is existing that by chickling, Growing Chicken, Adult Chicken Pullorum Disease, a situation arises and performance is described below:
1, the white scour of chicken: the white scour of chicken is one of chicken house commonly encountered diseases.Chickling start when 5-6 age in days morbidity, 2-3 week age be the white scour of chicken morbidity and peak mortality, its offspring's Hakuri of the kind chicken house of severe contamination is serious.Can cause the death of chickling 20%-30%, even higher sick chicken spirit is depressed, necking down of bowing, and feather is fluffy, and appetite declines, and eats less or does not eat.Because temperature rise is afraid of cold shiver with cold, sick chickling often flocks together and is crowded together, and closes one's eyes drowsiness.Outstanding performance is dysentery, discharges canescence loose stool, around cloaca feather often pollute by feces, many for defecation number, the dried feces of nephrodinic accent is stuck with paste.Sick chickling difficult defecation, exerts duty, groan as seen.Some acute disease chickens lose dysentery symptom before death.The sick chickling had breathes, dyspnea, some visible joint enlargements, walking disorder, limping.Linearly rising as prevented and treated improper sick chickling death, having obvious death curve.The good sick chickling of control reduces gradually, can also reach comparatively satisfied adult livability of brooding.In addition, though the survival rate during the chicken that broods is high, the pollution level that can not represent chickling group S. pullonum is low, only starts with from kind of a chicken house, does the infection rate of chicken table chickling group well.
2, middle chicken (Growing Chicken) Hakuri: the multiple chicken being born in 40-80 age in days of this disease, it is many that ground puts down that foster chicken mass-sending this comparatively online and Growing Chicken sick occurs.From kind, it is high that brown plumage produces brown laying hen kind.Growing Chicken morbidity has the impact of stressors more in addition, and as excessive in chicken population density, environmental health inclement condition, feeding and management is extensive, abrupt change of climate, feedstuff flip-flop or low quality etc.Primary disease occurs suddenly, full group chicken appetite, spirit still can, always see the chicken constantly occurring spiritual appetite difference and dysentery in chicken group, normal sudden death.Death loses peak but has every day chicken dead, and quantity differs.This course of disease is longer, can delay 20-30 days, and mortality rate can reach 10%-20%.
3, Adult Chicken Hakuri: Adult Chicken Hakuri is many in chronic process or inapparent infection.Generally lose obvious clinical symptoms, when chicken group infection proportion is larger, obviously can affect egg production, peak of laying eggs is not high, and hold time also short, death rate increases.The atrophy of some chickens performance cockscomb, when some chickens open product, cockscomb is grown fair, then shows cockscomb later and diminishes gradually, send out thin.Dysentery is had during sick chicken.
The chickling of Deaths, liver enlargement, hyperemia or have striated hemorrhage, gollbladder dilation, containing a large amount of bile.Pulmonary congestion or hemorrhage.The absorption of yolk at its that the course of disease is long is bad, in oils and fats sample or cheesy.On liver, lung, heart, intestinal and muscular stomach, there are yellow downright bad point or tuberosity, when the tuberosity on cardiac muscle increases, heart can be made significantly to be out of shape.Caecum portion expands, and its content has cheesy obstruction.The color and luster kermesinus or pale of kidney, renal tubules and dilatation of ureter, be full of urate.The common ovary shrinkage of Adult Hen, distortion, variable color, in cyst shape.Acute or chronic pericarditis.What the follicle of being encroached on had falls into abdominal cavity, causes general property peritonitis and ascites, abdominal organs adhesion.The atrophy of testis of cock, in cinerous, caseous substance in deferent duct, is had to fill and expand.The remarkable enlargement of some livers, quality is very crisp, often hepatorrhexis occurs.Cause serious internal hemorrhage, cause disease chicken sudden death.
Laboratory diagnosis: get hepatic necrosis stove and Hakuri tuberosity carries out histopathologic examination: local tissue necrosis disintegrate, lymphocyte, plasma cell, neutrophil cell, fibroblast infiltration hypertrophy.By the pathological material of disease that the organ pipe foregone conclusion official such as the heart, liver, spleen, lung, ovary of sick, dead chicken gathers, be inoculated in plain agar culture medium and carry out bacteriodiagnosis.After 24 hours, the petite that neat in edge, smooth surface, moistening flash of light, canescence are translucent, diameter is 1 centimetre can be grown.Get Sanguis Gallus domesticus to be checked and diagnostic antigen carries out plate agglutination test.
Occur according to primary disease during diagnosis and popular feature, distinctive symptom and cut open and examine the first visit made of pathological changes, to note doing with fowl typhoid, paratyphoid fever difference diagnosis: 1. Hakuri: clinically cut open inspection and can see in caecum and have cheesy thing to block intestinal tube simultaneously, sometimes be also mixed with a small amount of blood, in caecum and muscular stomach, have necrobiotic nodule.In addition, be also shown in the heart, liver, lung and present yellow and canescence necrosis knot circle Growing Chicken because of after Hakuri death, liver, lung enlargement, in kermesinus or darkviolet, quality is crisp and frangible.The characteristic pathological changes mainly hepatomegaly of fowl typhoid, in bronze.2. chicken secondary hurt: clinically cut open inspection and can see hemorrhagic enteritis and necrotic enteritis.Caseous substance is had, enteric hemorrhage in caecum.Distension related to the liver, the spleen-distension and pulmonary distension have hyperemia in various degree, hemorrhage and necrosis region.
Hakuri, for dysentery is just descended, white is sticky freezes or pus person.Ancient title whitish dysentery.Face card and must distinguish cold and heat.Holy Benevolent Prescriptions volume 59: " fight between intestinal, body fluid stagnates into white for Hakuri person, the empty and cold air visitor by intestinal, thus be Hakuri also." its disease is just lower to frozen glue or nasal mucus, doublely sees stomachache, rear heavy, can not eat, urine is sharp clearly, or deadly cold hand and foot etc.By cold and stagnate, caused by spleen sun is injured.Control suitable warming middle-JIAO for eliminating dampness, Chinese angelica powder, dehumidifying soup, ten benefit Tang Dengfang can be selected.Be more common in the disease such as chronic bacillary dysentery, chronic anaphylaxis colitis.If disease is white under seeing dysentery, glues and freeze many pus, stomachache, tenesmus, hot urination person, belonging to damp and hot for suffering from." Zhang Shi doctor logical " volume seven: " Hakuri from the beginning of, tenesmus, frequently for stepping on defecation, and to go and institute descend without many, just to rise and in abdomen again suddenly, all damp and hot sluggish caused by." controlling should clearing heat and expelling damp.
In fowl raising process, should be noted that the following aspects: (1) strengthens brooding management, room of brooding often keeps clean dry, temperature will remain constant, the diligent duty of shining of pad grass is changed, and chickling group can not overcrowding, and feedstuff will coordinate suitably, prevent chickling generation Carmibalism in Chicken, feed trough and water fountain prevent from being polluted by chicken manure.(2) note routine disinfection, frequent cleaning and sterilizing wanted by hen house and all apparatus, does the environmental health of chicken house well.Before application, with the sterilization of formaldehyde aerosol, brood room and all apparatus of brooding, often sterilize couveuse, and hatching eggs is sterilized with formaldehyde gas fumes before hatching.(3) performing regular SPS, is regularly eliminate bacillicarrier to breeder flock quarantine, the most effective measures of purification chicken group Pullorum Disease.Application whole blood slide agglutination test method, the quarantine of general breeder flock need carry out 2 ~ 3 times every year, and first time between 40 ~ 70 ages in days, should can quarantine 1 ~ 2 time continuously, every minor tick 10 ~ 15 days; Second time should be carried out in opening puerperal comprehensively, adheres to superseded positive chicken, to reach the object of purification chicken house.(4) to the chicken of newly buying, suitable medicine should be selected to prevent, contribute to controlling morbidity.
The Therapeutic Method of modern medicine mainly Drug therapy and putting prevention first, medicine used mainly contains furazolidone, oxytetracycline, chlortetracycline, tetracycline, gentamycin and kanamycin etc.Prevention: (1) quarantine purification chicken group: pass through serological test, detect and eliminate band strain chicken, secondary inspection in 60-7D age in days is carried out, second time inspection can be carried out when 16 week age, after to check every 1 month 1 time, find that positive chicken is eliminated in time, the positive rate until full group is no more than till 0.5%.(2) strict sterilization: 1. hatching egg sterilization.Pick in time, egg of choosing seeds, and respectively at after picking egg, entering couveuse, 18-19 day embryo rule in age time 3 use 28 milliliters of/meter 3 formalin fumigations 20 minutes.When hatching reaches about 50%, with 10 milliliters of/meter 3 formalin fumigations again in hatching device.2. hatching house sets up strict antisepsis system.3. brood house, be bred as the cleaning-sterilizing that house and Laying House carry out ground, apparatus, feed trough, cage tool, water fountain etc. and regularly Continuous disinfection carried out to chicken group.4. strengthen the management of dimension fowl raising, note chemoprophylaxis.In primary disease Prevalent district, the furazolidone of interpolation 0.04% can be replaced when brooding in feedstuff, 0.05% chloromycetin, 0.005% norfloxacin prevent.2. treat: furans, sulfonamides, antibiotic, quinolones are all effective in cure to primary disease, should select medicine, and note alternatively administered on the basis of drug sensitive test.0.04% furazolidone, 0.1% chloromycetin or O.03% compound sulfonamide-5-Sulfamonomethoxine can be added during morbidity in feedstuff, be used in conjunction 3-5 days.Or it is mould greatly to element 40,000 units per liter water to add celebrating in drinking-water, 0.008%, ampicillin 0.008%, norfloxacin, ciprofloxacin or Enrofloxacin Base 0.005%, is used in conjunction 3-5 days.Above-mentioned treatment and prevention scheme, medicine are all limited, do not reach desirable therapeutic effect, and treatment cost are higher.Compared with doctor trained in Western medicine, not only cure rate is high for Chinese medicine, instant effect, and drug residue free, cost price is low.Emphasize to regulate allomeric function, improve the premunition of chicken self, prolonged application is safe and reliable, can carry out marketing.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of pharmaceutical composition for the treatment of the white scour of chicken, the various defects of Chinese medicine of the prior art and Western medicine can be overcome, there is invigorating spleen to remove dampness, heat-clearing and toxic substances removing, effect of eliminating pathogenic heat from blood to cure dysentery, can also regulate chicken yang blood and qi, cure rate is high, treatment short treating period, drug residue are low, can strengthen immunity and the resistance against diseases of chicken simultaneously.
In order to realize foregoing invention object, the invention provides a kind of pharmaceutical composition for the treatment of the white scour of chicken, described pharmaceutical composition comprises following raw medicinal material: the Radix Pulsatillae, Cortex Phellodendri, Herba Potentillae Discoloris, Poria, Herba polygoni hydropiperis, Radix Sophorae Flavescentis, Herba Violae, Herba Hyperici Patuli, Herba Pteridis Multifidae, Flos Chrysanthemi Indici, Herba Andrographis, Herba cuscutae, geranium, Radix Cirsii Japonici, Massa Medicata Fermentata, Geranium strictipes R. Kunth, Rhizoma Atractylodis, Folium Callicarpae Formosanae, Herba Agrimoniae, Herba Acalyphae, Herba Taraxaci, Radix Puerariae, Flos Capsellae, Caulis Lonicerae, Indigo Naturalis, Cacumen Platycladi, the Rhizoma Atractylodis Macrocephalae, Herba Euphorbiae Humifusae and Semen Arecae.
In described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Radix Pulsatillae 15-35 weight portion, Cortex Phellodendri 12-24 weight portion, Herba Potentillae Discoloris 10-30 weight portion, Poria 15-35 weight portion, Herba polygoni hydropiperis 10-25 weight portion, Radix Sophorae Flavescentis 10-20 weight portion, Herba Violae 10-30 weight portion, Herba Hyperici Patuli 15-35 weight portion, Herba Pteridis Multifidae 12-22 weight portion, Flos Chrysanthemi Indici 13-28 weight portion, Herba Andrographis 12-32 weight portion, Herba cuscutae 13-33 weight portion, geranium 11-21 weight portion, Radix Cirsii Japonici 14-28 weight portion, Massa Medicata Fermentata 12-32 weight portion, Geranium strictipes R. Kunth 10-35 weight portion, Rhizoma Atractylodis 14-34 weight portion, Folium Callicarpae Formosanae 13-36 weight portion, Herba Agrimoniae 14-24 weight portion, Herba Acalyphae 13-36 weight portion, Herba Taraxaci 14-34 weight portion, Radix Puerariae 12-22 weight portion, Flos Capsellae 14-34 weight portion, Caulis Lonicerae 10-27 weight portion, Indigo Naturalis 10-35 weight portion, Cacumen Platycladi 12-32 weight portion, Rhizoma Atractylodis Macrocephalae 14-36 weight portion, Herba Euphorbiae Humifusae 13-33 weight portion and Semen Arecae 10-20 weight portion.
In described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: the Radix Pulsatillae 35 weight portion, Cortex Phellodendri 22 weight portion, Herba Potentillae Discoloris 30 weight portion, Poria 33 weight portion, Herba polygoni hydropiperis 20 weight portion, Radix Sophorae Flavescentis 15 weight portion, Herba Violae 25 weight portion, Herba Hyperici Patuli 34 weight portion, Herba Pteridis Multifidae 20 weight portion, Flos Chrysanthemi Indici 26 weight portion, Herba Andrographis 32 weight portion, Herba cuscutae 31 weight portion, geranium 20 weight portion, Radix Cirsii Japonici 28 weight portion, Massa Medicata Fermentata 30 weight portion, Geranium strictipes R. Kunth 35 weight portion, Rhizoma Atractylodis 32 weight portion, Folium Callicarpae Formosanae 36 weight portion, Herba Agrimoniae 24 weight portion, Herba Acalyphae 36 weight portion, Herba Taraxaci 34 weight portion, Radix Puerariae 22 weight portion, Flos Capsellae 28 weight portion, Caulis Lonicerae 12 weight portion, Indigo Naturalis 30 weight portion, Cacumen Platycladi 25 weight portion, the Rhizoma Atractylodis Macrocephalae 35 weight portion, Herba Euphorbiae Humifusae 33 weight portion and Semen Arecae 20 weight portion.
Described pharmaceutical composition also comprises Herba Potentillae Chinensis, Herba Hedyotidis Diffusae, Rhizoma Chiritae Fimbrisepalae and Semen vignae sinensis.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Pulsatillae 15-35 weight portion, Cortex Phellodendri 12-24 weight portion, Herba Potentillae Discoloris 10-30 weight portion, Poria 15-35 weight portion, Herba polygoni hydropiperis 10-25 weight portion, Radix Sophorae Flavescentis 10-20 weight portion, Herba Violae 10-30 weight portion, Herba Hyperici Patuli 15-35 weight portion, Herba Pteridis Multifidae 12-22 weight portion, Flos Chrysanthemi Indici 13-28 weight portion, Herba Andrographis 12-32 weight portion, Herba cuscutae 13-33 weight portion, geranium 11-21 weight portion, Radix Cirsii Japonici 14-28 weight portion, Massa Medicata Fermentata 12-32 weight portion, Geranium strictipes R. Kunth 10-35 weight portion, Rhizoma Atractylodis 14-34 weight portion, Folium Callicarpae Formosanae 13-36 weight portion, Herba Agrimoniae 14-24 weight portion, Herba Acalyphae 13-36 weight portion, Herba Taraxaci 14-34 weight portion, Radix Puerariae 12-22 weight portion, Flos Capsellae 14-34 weight portion, Caulis Lonicerae 10-27 weight portion, Indigo Naturalis 10-35 weight portion, Cacumen Platycladi 12-32 weight portion, Rhizoma Atractylodis Macrocephalae 14-36 weight portion, Herba Euphorbiae Humifusae 13-33 weight portion, Semen Arecae 10-20 weight portion, Herba Potentillae Chinensis 10-35 weight portion, Herba Hedyotidis Diffusae 10-25 weight portion, Rhizoma Chiritae Fimbrisepalae 13-31 weight portion and Semen vignae sinensis 10-27 weight portion.
In described pharmaceutical composition, the parts by weight of each raw medicinal material are: the Radix Pulsatillae 35 weight portion, Cortex Phellodendri 22 weight portion, Herba Potentillae Discoloris 30 weight portion, Poria 33 weight portion, Herba polygoni hydropiperis 20 weight portion, Radix Sophorae Flavescentis 15 weight portion, Herba Violae 25 weight portion, Herba Hyperici Patuli 34 weight portion, Herba Pteridis Multifidae 20 weight portion, Flos Chrysanthemi Indici 26 weight portion, Herba Andrographis 32 weight portion, Herba cuscutae 31 weight portion, geranium 20 weight portion, Radix Cirsii Japonici 28 weight portion, Massa Medicata Fermentata 30 weight portion, Geranium strictipes R. Kunth 35 weight portion, Rhizoma Atractylodis 32 weight portion, Folium Callicarpae Formosanae 36 weight portion, Herba Agrimoniae 24 weight portion, Herba Acalyphae 36 weight portion, Herba Taraxaci 34 weight portion, Radix Puerariae 22 weight portion, Flos Capsellae 28 weight portion, Caulis Lonicerae 12 weight portion, Indigo Naturalis 30 weight portion, Cacumen Platycladi 25 weight portion, the Rhizoma Atractylodis Macrocephalae 35 weight portion, Herba Euphorbiae Humifusae 33 weight portion, Semen Arecae 20 weight portion, Herba Potentillae Chinensis 34 weight portion, Herba Hedyotidis Diffusae 22 weight portion, Rhizoma Chiritae Fimbrisepalae 30 weight portion and Semen vignae sinensis 25 weight portion.
In order to better realize foregoing invention object, the invention provides a kind of preparation method for the treatment of the pharmaceutical composition of the white scour of chicken, when the dosage form of pharmaceutical composition is injectable powder, its preparation method comprises the following steps:
The dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
The dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:
The first step, Herba Andrographis, Herba cuscutae, geranium, Radix Cirsii Japonici, Massa Medicata Fermentata, Geranium strictipes R. Kunth and Rhizoma Atractylodis are mixed in described ratio, be the dissolve with ethanol of 85% ~ 95% with the determining alcohol of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Flos Capsellae, Caulis Lonicerae, Indigo Naturalis, Cacumen Platycladi, the Rhizoma Atractylodis Macrocephalae, Herba Euphorbiae Humifusae and Semen Arecae are mixed in described ratio, add the ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, again heat decoction 1 ~ 2 hour, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 80 ~ 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.
The invention has the beneficial effects as follows: pharmaceutical composition of the present invention has invigorating spleen to remove dampness, heat-clearing and toxic substances removing, effect of eliminating pathogenic heat from blood to cure dysentery, chicken yang blood and qi can also be regulated, cure rate is high, and treatment short treating period, drug residue are low, can strengthen immunity and the resistance against diseases of chicken simultaneously.
Detailed description of the invention
" doctor's rock " rolls up three: " dysentery by caused by damp and hot, or the thing that diet is damp and hot, or experience damp and hot gas; amass in the intestines and stomach, be then just evil resistance, the operation of taste is not normal; so diet is stagnated day by day, turn to and lose turbid, among gluing the intestines and stomach; the machine of operations, benefit is with unfavorable, and the stagnation of QI be fiery; be mixed into heresy with suffered damp and hot gas, attack thorn and have a pain ... " there is bellyache and diarrhea secondary frequent, red white the gluing of lower profit is frozen, the diseases such as tenesmus.More explicitly point out dysentery later age many by unhygienic diet, experience the gas of epidemic disease poison, intestinal is produced stagnant, conduct not normal caused by, when distinguishing that its deficiency and excess point another matter is controlled.And red white the gluing of dysentery institute purgation is frozen, " medicine principle dysentery door " is called: " its red person's blood system is injured, belongs to small intestinal; White person's edema caused by disorder of QI is injured, belongs to large intestine." " bright doctor's fingers and palms ": " and damp and hot long-pending, do in blood system then red, do in edema caused by disorder of QI then white." "Nei Jing" claims primary disease to be " intestinal trip ", the aspect such as the cause of disease, symptom, prognosis of primary disease is discussed, all to some extent as " the bright opinion of the lunar sun of Plain Questions " is said: " food drink does not save, daily life is person frequently, cloudy by it ... pathogens in YIN parts of the body being apt to enter five ZANG-organs, dirty then film is full inaccessible, and lower is lientery, for a long time for intestinal is debated." point out that the primary disease cause of disease is relevant with eating and drinking without temperance." Plain Questions, the most pure virginity will be discussed greatly " is said: " fire is excessive to be won ... the sick dysentery of the people ... stomachache dark coloured urine, very hemafecia." point out that the cause of disease of primary disease is relevant with weather, symptom is stomachache, just lower in vain red.Primary disease is collectively referred to as " lower profit " with having loose bowels by the Chinese " the Medical Treasures of the Golden Chamber vomiting sound of vomiting lower sharp abnormal pulse demonstrate,prove and controls ", has formulated the different Radix Pulsatillae Decoction of cold and heat and primary disease treated by Taohua Tang, and started the determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs of dysentery, two sides are always by doctor's later age is liked use.Sui's " General Treatise on the Cause and Symptoms of Diseases " has " dysentery with red and white feces ", " dysentery ", " purulent dysentery ", " hematodiarrhoea " etc. more than 20 to plant dysentery to wait and record, have more deep understanding to the clinical manifestation of primary disease and the cause of disease, pathogenesis.
Pharmaceutical composition of the present invention follows the principle of invigorating the spleen and benefiting QI, removing toxic substances antidiarrheal, provide a kind of pharmaceutical composition for the treatment of the white scour of chicken, comprise following raw medicinal material: the Radix Pulsatillae, Cortex Phellodendri, Herba Potentillae Discoloris, Poria, Herba polygoni hydropiperis, Radix Sophorae Flavescentis, Herba Violae, Herba Hyperici Patuli, Herba Pteridis Multifidae, Flos Chrysanthemi Indici, Herba Andrographis, Herba cuscutae, geranium, Radix Cirsii Japonici, Massa Medicata Fermentata, Geranium strictipes R. Kunth, Rhizoma Atractylodis, Folium Callicarpae Formosanae, Herba Agrimoniae, Herba Acalyphae, Herba Taraxaci, Radix Puerariae, Flos Capsellae, Caulis Lonicerae, Indigo Naturalis, Cacumen Platycladi, the Rhizoma Atractylodis Macrocephalae, Herba Euphorbiae Humifusae, Herba Potentillae Chinensis, Herba Hedyotidis Diffusae, Rhizoma Chiritae Fimbrisepalae, Semen Arecae and Semen vignae sinensis.
The pharmacological property of above-mentioned each raw medicinal material is as follows:
Semen vignae sinensis: nature and flavor: sweet is flat.Cure mainly: invigorating spleen to remove dampness, heat-clearing and toxic substances removing, hemostasis.
Herba cuscutae: nature and flavor: sweetness and bitterness; Flat.Gui Jing: liver; Kidney; Urinary bladder channel.Cure mainly: heat-clearing and toxic substances removing; Cooling blood for hemostasis; Invigorating spleen to remove dampness.Main haematemesis; Epistaxis; Have blood in stool; Metrorrhagia; Stranguria with turbid discharge; Leukorrhagia; Dysentery; Yellow cellulitis; Loose stool; Conjunctival congestion and swelling pain; Laryngopharynx swelling and pain; Swollen ulcer drug; Miliaria.
Rhizoma Chiritae Fimbrisepalae: nature and flavor: bitter, cool.Cure mainly: strengthening the spleen to promote digestion, clearing away heat-damp and promoting diuresis, promoting blood circulation and stopping pain.For infantile malnutrition, stomachache, hepatitis, dysentery, hemoptysis of pulmonary tuberculosis; It is hemorrhage that knife injury is controlled in external, innominate toxic swelling, traumatic injury.
Flos Capsellae: nature and flavor with return through: sweet, light, cool.Enter liver, stomach warp.Effect: hemostasis, blood pressure lowering, clearing away heat-damp and promoting diuresis.
Folium Callicarpae Formosanae: nature and flavor with return through: bitter, cold.Return liver, spleen, lung meridian.Effect: hemostasis, removing toxic substances.
Geranium strictipes R. Kunth: source: " the southern regions of the Yunnan Province book on Chinese herbal medicine ".Nature and flavor: bitter; Puckery; Be slightly cold.Gui Jing: liver; Spleen; Stomach; Urinary bladder channel.Cure mainly: clearing away heat-damp and promoting diuresis; Cooling blood for hemostasis.Master has loose bowels; Dysentery; Dyspepsia; Gastral cavity abdomen; Epistaxis; Have blood in stool; Have through too much; Postpartum hemorrhage is more than; Traumatic injury.
Rhizoma Atractylodis: nature and flavor: pungent, bitter, temperature.Gui Jing: return spleen, stomach, Liver Channel.Cure mainly: drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, have loose bowels, edema, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.
Poria: source: " herbal classic ".Nature and flavor: sweet light are flat.1. " herbal classic ": " sweet in the mouth is flat." 2. " medicine origin ": " " curing mainly secret formula " cloud, warm in nature, lightly seasoned." return through: enter the heart, spleen, lung meridian.1. Materia Medica of Decoction: " start with large cloudy, the large sun of foot, shaoyang channel." 2. " book on Chinese herbal medicine covers bamboo fish trap ": " enters bladder, kidney, lung." 3. " Thunder God concocts property of medicine solution ": " enters lung, spleen, small intestinal three warp.It is few cloudy that " 4. " Bencao Jingshu ": " enters brothers, the hands sun, lunar, the Yangming Channel of foot." cure mainly: eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Control dysuria, edema distension, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.
Herba Potentillae Chinensis: nature and flavor: bitter, cold.Gui Jing: return liver, large intestine channel.Cure mainly: heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.For bloody dysentery stomachache, chronic dysentery is more than, bleeding hemorrhoids, carbuncle sore tumefacting virus.
Cacumen Platycladi: nature and flavor with return through: bitter, puckery, be slightly cold.Enter lung, liver, large intestine channel.Effect: cooling blood for hemostasis.
Herba Hyperici Patuli: nature and flavor: micro-hardship, cold.Cure mainly: heat-clearing and toxic substances removing, cooling blood for hemostasis, parasite killing, antipruritic.Herb: upper respiratory tract infection, hepatitis, dysentery, nephritis.Really: metrorrhagia, epistaxis.Leaf: skin pruritus is controlled in external, impetigo.Root: ascarifuge.
Herba Acalyphae: nature and flavor with return through: micro-hardship, puckery, flat.Effect: hemostasis, antidiarrheal, heat-clearing and toxic substances removing.
Indigo Naturalis: salty in the mouth, cold in nature, enter Liver Channel, heat-clearing and toxic substances removing, cooling blood for hemostasis.
Herba Euphorbiae Humifusae: nature and flavor with return through: pungent, flat.Effect: hemostasis, antidiarrheal, heat-clearing and toxic substances removing.
Radix Cirsii Japonici: nature and flavor with return through: sweet, cool.Enter Liver Channel.Effect: removing heat from blood, hemostasis.
The Radix Pulsatillae: bitter in the mouth, cold in nature; Return stomach warp, large intestine channel." herbal classic is met former ": " Radix Pulsatillae, " herbal classic " says bitter temperature person, and the mistake made private copy of also.It controls the diseases such as the mad easy cold and heat of pyrexial malaria, the disease of all few sun, positive bright pathogenic heat consolidation, and the loose then hematocele of knot goes and only suffers from abdominal pain." not Lu " be epistaxis only, and great scape stops fulminant dysentery, is also the time that pyretic toxicity enters blood trouble and divides." " property of medicine opinion ": " only stomachache and also fulminant dysentery, control toothache, tumor scrofula under major event.Main hundred pain all over the joints." can heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, removing dampness and killing parasites, for pyretic toxicity dysentery, epistaxis, internal hemorrhoid with bleeding, leukorrhagia, pudendal pruritus, carbuncle skin ulcer, scrofula.
Cortex Phellodendri: be the dry bark of rutaceae wampee or Cortex Phellodendri.The former practises title " Cortex Phellodendri ", and the latter practises title " Cortex Phellodendri ".Can be used as medicine, nature and flavor bitter cold, has heat clearing and damp drying, and pathogenic fire purging removes steams, effect of detoxification sore treatment.Cortex Phellodendri is conventional Chinese medicine, and its cold in nature, bitter in the mouth, the effects such as tool heat clearing and damp drying, eliminating fire and detoxication, are usually used in damp-heat dysentery, jaundice, leucorrhea and the disease such as pyretic arthralgia, pyretic stranguria.Modern study shows, Cortex Phellodendri is containing the main component such as berberine, obacunone, and have the effect of antibacterial, convergence, antiinflammatory, to symptoms such as various skin noxious dampness, skin infection, effect is good." herbal classic is met former " is said: " Cortex Phellodendri, raw with falling excess-fire, processed with wine is controlled in YIN-fire scorching, and salt system controls the inferior the fire of Jiao, and processed with Rhizoma Zingiberis Recens controls middle burnt phlegm-fire, and Sucus Zingberis is fried and blackly controlled damp and hot, and black asthenic fire processed fried by salt wine, deficiency of YIN fire Sheng flushed complexion floating YANG, Radix Aconiti Lateralis Preparata juice system ".
Herba Potentillae Discoloris: sweet, micro-hardship, flat, nontoxic." vegetation is side just ": " clear sharp the intestines and stomach, except rheumatism.Control red white chronic dysentery and become infantile malnutrition, be coated with and dislike lyssodexis." Compendium of Material Medica: " controls haematemesis, hematochezia, metrorrhagia, malaria, carbuncle skin ulcer." heat-clearing and toxic substances removing, dysentery relieving stops blooding.Women's red and white leukorrhea and menorrhagia disease can be controlled.Through clinical verification, this product has therapeutic efficiency to diabetes.Composition fumaric acid, gallic acid acid, protocatechuic acid, Quercetin, naringenin, kaempferol, isophthalic acid is raised in Herba Potentillae Discoloris, to Fu Shi and shigella, there is bacteriostasis, especially the strongest with gallic acid and Quercetin activity, minimum inhibitory concentration is respectively 59ppm/ml and 37ppm/ml.Herb decoct flat board burrows method, has inhibitory action to shigella and shigella flexneri.
The Rhizoma Atractylodis Macrocephalae: sweet in the mouth, hardship, warm in nature, enter spleen, stomach warp, have spleen reinforcing promoting the circulation of QI, dampness diuretic, strengthening superficial resistance to stop perspiration, effect that activating the spleen is moisturized, cure mainly the feeling of fullness diarrhoea that dysfunction of the spleen in transportation, QI failing to transform into body fluid are caused, phlegm retention edema; The vexed lazyness speech of deficiency of QI in middle-JIAO, metrorrhagia and metrostaxis, proctoptosis with chronic dysentery; The cards such as solid in the playing of deficiency of the spleen causing weakness of QI, sweating due to debility spontaneous perspiration, the Rhizoma Atractylodis Macrocephalae can promote gastric secretion, strengthens the Absorption of small intestinal, has regulating action to gastrointestinal function.
Herba polygoni hydropiperis: pungent, temperature; Return lung, liver, large intestine channel.Function expelling wind and removing dampness, eliminating stasis to stop pain, removing toxic substances and promoting subsidence of swelling, killing parasites for relieving itching.For dysentery, have loose bowels, tonsillitis, malaria, rheumatic arthralgia, treating swelling and pain by traumatic injury, metrorrhagia, arthritis, carbuncle furuncle, scrofula, venom, eczema, tinea pedis, traumatic hemorrhage.Its fluid extract and extract thereof have stronger bacteriostasis to staphylococcus aureus, bacillus pyocyaneus, Hemolytic streptococcus.
Radix Sophorae Flavescentis: the effect having anti-inflammation, all has inhibitory action to Propiobacterium, staphylococcus aureus, escherichia coli, can diuresis, antiallergic, ease pain, relieving asthma, eliminate the phlegm.Bitter in the mouth; Cold in nature.Return liver; Kidney; Large intestine; Small intestine meridian; Bladder; Heart channel; Urinary bladder channel.Effect: heat clearing and damp drying: extensive use and multiple humidifier fever, as damp-heat dysentery external can decoct soup washout, for hemorrhoid, women gynecological; Parasite killing (external), diuresis.Can heat clearing and damp drying; Wind dispelling insecticide.Main damp-heat dysentery, discharging fresh blood stool, jaundice, dysuria, edema, leukorrhagia, pudendal pruritus, scabies, leprosy, skin pruritus, noxious dampness skin infection.
Herba Violae: Herba Corydalis Bungeanae is the herb of bloodroot corydalis bungeana.Summer gathers herb, cleans, dries, cutting.Another name: Herba Violae, Herba Violae, Herba Violae, Seem Lablab Album seedling, chicken dish.Under being born in gully, streams and Plain, hilly grassland or sparse woods.The ground such as distribution Gansu, Shaanxi, Shanxi, Shandong, Hebei, Liaoning, Jilin, Heilungkiang, Sichuan.Cure mainly: heat-clearing and toxic substances removing; Subduing inflammation.Main influenza; Upper respiratory tract infection; Tonsillitis; Infectious hepatitis; Intestinal is scorching; Dysentery; Nephritis; Parotitis; Conjunctivitis; Acute appendicitis; Furuncle carbuncle; Scrofula.Heat-clearing and toxic substances removing.Control furuncle carbuncle, jaundice interior-heat, children's's nose bleeding, appendicitis, venom.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": removing blood stasis, carbuncle mange is separated, nine kinds of hemorrhoid, all sore diseases.2. " detailed outline ": cure mainly all carbuncle carbuncle on the back, furuncle swells scrofula, innominate toxic swelling, malignant boil.3. " book on Chinese herbal medicine asks former ": removing heat from blood, detumescence poison.Control heat in blood flaccidity due to malnutrition of tendons, deposited skin ulcer is wonderful.4. " south of the Five Ridges gather medicinal herbs record ": make cathartic and tell medicine.5. " Chinese herbal medicine is commonly used in Shanghai ": heat-clearing and toxic substances removing, externally applied toxicity removing detumescence.Control conjunctival congestion and swelling pain, hordeolum, treat pyogenic infections from tumour or sore, acute mastitis, enteritis, diarrhea, venom.6. revive doctor's " Chinese herbal medicine handbook ": control all pyogenic infections, venom, lymphoid tuberculosis, jaundice, nephritis, cystitis, arthralgia, have blood in stool, epistaxis, eye conjunctivitis, prostatitis.
Herba Pteridis Multifidae: light, micro-hardship is cool." the SHENGCAO property of medicine is standby to be wanted ": " wash infantile malnutrition, furuncle, hemorrhoid, loose poison, applies skin ulcer.Control Serpentis and sting all poison, knife injury, energy hemostasia and promoting granulation, spring juice rectification clothes, slag applies affected part.Grinding into powder harvests and store controls pain due to disorder of QI." " conventional Chinese herbal medicine handbook ": " heat clearing away, dampness removing, removing heat from blood.Control bacillary dysentery, enteritis, fever caused by exogenous pathogens, urinary tract infection, leucorrhea, parotitis, furuncle, eczema." clearing away heat-damp and promoting diuresis, removing toxic substances dysentery relieving, cooling blood for hemostasis.For dysentery, gastroenteritis, hepatitis, urinary system infection, cat fever, laryngopharynx swelling and pain, leucorrhea, metrorrhagia, pesticide intoxication; Traumatic hemorrhage is controlled in external, burn and scald.
Flos Chrysanthemi Indici: cold nature, bitter in the mouth, pungent.Heat-clearing and toxic substances removing, furuncle of drawing out pus by applying a plaster to the affected part." book on Chinese herbal medicine converges and says ": " removing blood stasis is soothing the liver, separates the loose poison of furuncle.Stagnated blood in housewife people's abdomen, the red furuncle of the capable fire-toxin of Xie Tian.Wash skin ulcer scabies, wind parasite killing can be removed again." function heat-clearing and toxic substances removing, detumescence.To staphylococcus aureus, diphtheria corynebacterium, streptococcus, bacillus pyocyaneus, puncture Shigella, influenza virus, all there is inhibitory action.To furuncle, carbuncle, erysipelas, eczema, dermatitis, anemopyretic cold, laryngopharynx swelling and pain, hypertension etc. have good curative effect.
Herba Andrographis: have another name called Chun Lianqiuliu, Herba Andrographitis, Lan Helian, Radix Gentianae, golden Rhizoma et radix valerianae, Tremella aurantialba Bandoni et Zang hook, India's grass, Herba vallisneriae Spiralis etc.There are heat-clearing and toxic substances removing, antiinflammatory, reducing swelling and alleviating pain effect.Cure mainly bacillary dysentery, urinary tract infection, acute tonsillitis, enteritis, pharyngolaryngitis, pneumonia and influenza etc., external can treat furuncle toxic swelling, trauma infection contamination etc.Herba Andrographis has eliminating inflammation and expelling toxin effect, once multi-infection disease was applied to clinically, comprise trauma infection contamination, furuncle, carbuncle, erysipelas, upper respiratory tract infection, acute and chronic tonsillitis, acute and chronic pharyngitis, acute/chronic bronchitis, acute bacillary dysentery, acute gastroenteritis, urinary tract infection, endometritis, pelvic inflammatory disease, otitis media, periodontitis etc., all have curative effect in various degree.Preparation and usage: make injection punishment, oral capsule or tablet, consumption must be looked various places and produce the different content of preparation and different.To general inflammation infection, can the decoction of Herba Andrographis Radix Glycyrrhizae 2 ~ 3 money, every day 1 dose; Or tablet (the suitable crude drug in whole of every sheet 1 gram) takes orally, each 4 ~ 8, every day 3 ~ 4 times.To cutization pyogenic infection wound surface, available Folium Andrographis is ground into powder, makes 1:4 aqueous solution, leaching gauze external application wound.Ear drop topical application be can be made into suppurative otitis media, simultaneously Tabellae Andrographitis for oral administration.
Geranium: acrid in the mouth, hardship, property is put down, and returns liver,kidney,spleen warp, has wind-damp dispelling, the meridian dredging, effect of antidiarrheal profit, for rheumatic arthralgia, numbness contracture, the cards such as muscles and bones is ached, dysentery.
Massa Medicata Fermentata: nature and flavor are bitter, temperature.1. " property of medicine is examined ": " micro-bitter fragrant sweet." 2. " detailed outline is picked up any lost article from the road ": " and sweet light, delicate fragrance." enter spleen, stomach, large intestine channel.After flour, wheat bran and multi-medicament are mixed, through the herbal leaven of fermentation.Can strengthening the spleen to promote digestion, regulating QI to expel dampness, induces sweat.Cure the wound the food feeling of stuffiness in chest, and stomachache is vomited and diarrhoea, dysentery, headache due to common cold, and children's hinders hungry mistake and satisfies.Yeast is had in Massa Medicata Fermentata.Its composition has volatile oil, glycoside, fatty oil and vitamin B etc." Bencao Jingshu " is said: " ancients are bent, the song namely brewed alcoholic beverages, the sweet temperature of its abnormal smells from the patient, the special food stagnation removing of property, the stagnant gas of row taste, and loose internal organs are air-cooled.Massa Medicata Fermentata is that descendant specially makes, and with hyoscine, doubles in distillers yeast ".
Herba Agrimoniae: slightly warm in nature, bitter and puckery flavor." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control married woman's menstruation or before or after, leucorrhea with red and white discharge, the cold stomachache in face, with the passing of time red white dysentery." " BAICAO mirror ": " therapeutic method to keep the adverse QI flowing downwards is invigorated blood circulation, reason all kinds of diseases and ailments, loose feeling of fullness; Traumatic injury is spitted blood, metrorrhagia, dysentery, discharging fresh blood stool." astringing to arrest bleeding, dysentery relieving, parasite killing.Be widely used in various hemorrhage card, such as: haematemesis, hematuria, have blood in stool, metrorrhagia, spitting of blood, epistaxis, dysentery, impairment caused by overstrain takes off power, carbuncle, traumatic injury, the cards such as wound hemorrhage.Anaphylaxis: show as uncomfortable in chest, breathe hard, cardiopalmus, agitation, dizziness and blurred vision, dripping sweat, pale complexion, cold limbs, shiver with cold, blood pressure drops.Severe one still has dizziness, flushed face, dripping sweat.Toxic retrobulbar neuritis is blind, abdominal pain diarrhea, vomiting, flushing, blood pressure drops.
Herba Taraxaci: nature and flavor are sweet, micro-hardship, cold.Heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation.Enter spleen, stomach, kidney three warp.Can be used for upper respiratory tract infection, eye conjunctivitis, mumps, hyperglycemia, acute mastitis swells and ache, gastritis, dysentery, hepatitis, cholecystitis, acute appendicitis, urinary system infection, pelvic inflammatory disease, carbuncle furuncle furuncle, pharyngitis, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, urinary tract infection.Containing multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in Herba Taraxaci plant, there are the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting.Herba Taraxaci, simultaneously containing protein, fat, carbohydrate, trace element and vitamin etc., has abundant nutritive value, raw-eaten, stir-fry and eat, cook soup, is the plant of dietotherapeutic.Experiment proves, Herba Taraxaci is to staphylococcus aureus, Hemolytic streptococcus, Diplococcus pneumoniae, meningococcus, diphtheria corynebacterium, bacillus pyocyaneus, dysentery bacterium, Bacillus typhi, micrococcus catarrhalis etc., all there is killing action, also have certain inhibitory action to tubercule bacillus, some fungus and virus.Therefore antibiotic usage can be replaced to a certain extent.
Radix Puerariae: cool in nature, sweet in the mouth, pungent, enter spleen, stomach warp.The famous physician's Li Shizhen (1518-1593 A.D.) of the Ming Dynasty has carried out systematic research to Radix Puerariae, think the stem of Radix Puerariae, leaf, flower, really, root all can be used as medicine.He records like this in Compendium of Material Medica: " Pueraria lobota, property is sweet, pungent, flat, nontoxic, cures mainly: quench one's thirst, high fever of the body, vomiting, all frauds, cloudy gas, separates all poison ".Can yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is temperature only.Cure the wound cold, warm headache stiffness of the nape, and dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery, and skin eruption is not saturating, hypertension, and angina pectoris is deaf.
Caulis Lonicerae: sweet in the mouth, cold in nature, attach to the lung and stomach meridians, there is heat-clearing and toxic substances removing, effect of dispelling wind dredging collateral, cure mainly epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle skin infection, beriberoid pyretic arthralgia, the cards such as redness and swelling of joints burning pain.
Herba Hedyotidis Diffusae: bitter in the mouth, sweet, cold in nature, enters the heart, liver, spleen, large intestine channel, has heat-clearing and toxic substances removing, the effect of promoting diuresis to eliminate damp pathogen, for dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, acute appendicitis, furuncle and phyma skin infection, venom, the puckery pain of pyretic stranguria, edema, dysentery, enteritis, jaundice due to damp-heat, the cards such as cancerous protuberance.
Semen Arecae: bitter in the mouth; Pungent; Warm in nature.Return stomach; Large intestine channel.Have parasite killing, removing mass, sending down the abnormal ascending QI is capable stagnant, and row aquation wets.Effect.Cure mainly rapid digestion of food to relieve oedema or abdominal distension through diuresis or purgation, kill intestinal volt corpse, proglottid of tapeworm; Except dampness, get round by bribery, sharp nine orifices, relieving restlessness, caking in broken abdomen; Also can control beriberi, edema, chest pain, dysentery, abdominal distention is suffered from abdominal pain, defecation is unfavorable, mental disorder dyspnea with rapid respiration, treat pernicious malaria, resist communicable subtropical diseases." detailed outline ": semen arecae goes out ridge table, the southern regions of the Yunnan Province, the i.e. flat and puckery person of a kind of enlarged abdomen shape in Semen Arecae, not like the good ear of the Semen Arecae long taste of point, so-called chicken Semen Arecae person is.Cover the different of also local products, moderns very do not distinguish.By Liu Xun " ridge table record " cloud, to hand over, wide survivor, Semen Arecae on non-oceangoing ship, all semen arecae also, know in that and exhale as Semen Arecae, delicate and old, adopt and real eat it, stay rattan, watt room ash with food to hold up, with communicable subtropical diseases of dispelling, receive its skin to be used as medicine, the outer black of skin, Intradermal all muscle silk as Cortex cocois radicis (Cocos nucifera L.)." Yunnan note " cloud again, large abdomen Semen Arecae every has three, 200, cuts open it time blue or green, rolls up and eats it, namely subtract astringent taste with a slice betel leaf and Pulvis concha Mactrae.See this one to say, then semen arecae and Semen Arecae can be general, but the slightly bad ear of force rate Semen Arecae.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 pharmaceutical composition 1
Embodiments provide a kind of pharmaceutical composition for the treatment of the white scour of chicken, be made up of the raw medicinal material of following parts by weight: the Radix Pulsatillae 35 weight portion, Cortex Phellodendri 22 weight portion, Herba Potentillae Discoloris 30 weight portion, Poria 33 weight portion, Herba polygoni hydropiperis 20 weight portion, Radix Sophorae Flavescentis 15 weight portion, Herba Violae 25 weight portion, Herba Hyperici Patuli 34 weight portion, Herba Pteridis Multifidae 20 weight portion, Flos Chrysanthemi Indici 26 weight portion, Herba Andrographis 32 weight portion, Herba cuscutae 31 weight portion, geranium 20 weight portion, Radix Cirsii Japonici 28 weight portion, Massa Medicata Fermentata 30 weight portion, Geranium strictipes R. Kunth 35 weight portion, Rhizoma Atractylodis 32 weight portion, Folium Callicarpae Formosanae 36 weight portion, Herba Agrimoniae 24 weight portion, Herba Acalyphae 36 weight portion, Herba Taraxaci 34 weight portion, Radix Puerariae 22 weight portion, Flos Capsellae 28 weight portion, Caulis Lonicerae 12 weight portion, Indigo Naturalis 30 weight portion, Cacumen Platycladi 25 weight portion, the Rhizoma Atractylodis Macrocephalae 35 weight portion, Herba Euphorbiae Humifusae 33 weight portion and Semen Arecae 20 weight portion.
Its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 3 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 4 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 90%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 30 hours under the condition of 9 DEG C, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 50 minutes at this, the micron particles of acquisition 4 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets the mixed powder 15g that second step obtains, adds propylene glycol 40g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1.5g needle-use activated carbon, fully stirs 40 minutes; Decarbonization filtering; With 0.23 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
Embodiment 2 pharmaceutical composition 2
Embodiments provide a kind of pharmaceutical composition for the treatment of the white scour of chicken, be made up of the raw medicinal material of following parts by weight: the Radix Pulsatillae 35 weight portion, Cortex Phellodendri 22 weight portion, Herba Potentillae Discoloris 30 weight portion, Poria 33 weight portion, Herba polygoni hydropiperis 20 weight portion, Radix Sophorae Flavescentis 15 weight portion, Herba Violae 25 weight portion, Herba Hyperici Patuli 34 weight portion, Herba Pteridis Multifidae 20 weight portion, Flos Chrysanthemi Indici 26 weight portion, Herba Andrographis 32 weight portion, Herba cuscutae 31 weight portion, geranium 20 weight portion, Radix Cirsii Japonici 28 weight portion, Massa Medicata Fermentata 30 weight portion, Geranium strictipes R. Kunth 35 weight portion, Rhizoma Atractylodis 32 weight portion, Folium Callicarpae Formosanae 36 weight portion, Herba Agrimoniae 24 weight portion, Herba Acalyphae 36 weight portion, Herba Taraxaci 34 weight portion, Radix Puerariae 22 weight portion, Flos Capsellae 28 weight portion, Caulis Lonicerae 12 weight portion, Indigo Naturalis 30 weight portion, Cacumen Platycladi 25 weight portion, the Rhizoma Atractylodis Macrocephalae 35 weight portion, Herba Euphorbiae Humifusae 33 weight portion, Semen Arecae 20 weight portion, Herba Potentillae Chinensis 34 weight portion, Herba Hedyotidis Diffusae 22 weight portion, Rhizoma Chiritae Fimbrisepalae 30 weight portion and Semen vignae sinensis 25 weight portion.
Its preparation method is as follows:
The first step, Herba Andrographis, Herba cuscutae, geranium, Radix Cirsii Japonici, Massa Medicata Fermentata, Geranium strictipes R. Kunth and Rhizoma Atractylodis are mixed in described ratio, be the dissolve with ethanol of 90% with the determining alcohol of 4 times relative to the mixture quality obtained, reflux was extracted after 3 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 90% of 2 times relative to the mixture quality obtained, reflux was extracted after 2 hours, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Flos Capsellae, Caulis Lonicerae, Indigo Naturalis, Cacumen Platycladi, the Rhizoma Atractylodis Macrocephalae, Herba Euphorbiae Humifusae and Semen Arecae are mixed in described ratio, add the ethanol of the determining alcohol 90% of 3 times relative to the mixture quality obtained, heating and refluxing extraction 2 times, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 65 DEG C 60 DEG C, relative density is the mastic of 1.22, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 3 times relative to the mixture quality obtained, and heating decoction 3 hours, filters; By filtering residue again with the water dissolution of 1.5 times relative to the mixture quality obtained, again heat decoction 1.5 hours, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 100 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.
The toxicity test of pharmaceutical composition:
1, trial drug
Choose Radix Pulsatillae 35g, Cortex Phellodendri 22g, Herba Potentillae Discoloris 30g, Poria 33g, Herba polygoni hydropiperis 20g, Radix Sophorae Flavescentis 15g, Herba Violae 25g, Herba Hyperici Patuli 34g, Herba Pteridis Multifidae 20g, Flos Chrysanthemi Indici 26g, Herba Andrographis 32g, Herba cuscutae 31g, geranium 20g, Radix Cirsii Japonici 28g, Massa Medicata Fermentata 30g, Geranium strictipes R. Kunth 35g, Rhizoma Atractylodis 32g, Folium Callicarpae Formosanae 36g, Herba Agrimoniae 24g, Herba Acalyphae 36g, Herba Taraxaci 34g, Radix Puerariae 22g, Flos Capsellae 28g, Caulis Lonicerae 12g, Indigo Naturalis 30g, Cacumen Platycladi 25g, Rhizoma Atractylodis Macrocephalae 35g, Herba Euphorbiae Humifusae 33g and Semen Arecae 20g to mix, be ground into powder; Added by acquisition powder in 1400g cold water and soak 25 hours, with slow fire boiling, decocting time is 1.5 hours, decoction liquor is filtered, obtains the first filtrate, collects filtering residue; Again add in 1400g cold water by filtering the filtering residue obtained, with slow fire boiling 3 times, each decoction 1 hour, filters and merges filtrate, obtaining the second filtrate; Merge twice filtrate, concentrating under reduced pressure remove portion water, obtain decoction, the crude drug concentration of decoction is 3g/ml.
2, test method: select SD rat, give the decoction of the Chinese medicine additive of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crca, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: Chinese medicine additive of the present invention is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.
Contrast test
Liaocheng of Shandong Province chicken plant, in by the end of December, 2012, find that breathing in various degree appears in 450 20 Japanese instar chicklings nearly, dyspnea, arthroncus, walking disorder, walk lamely, spirit is depressed, to bow necking down, feather is fluffy, appetite declines, eat less or do not eat, to be afraid of cold shiver with cold, often flock together and be crowded together, close one's eyes drowsiness, difficult defecation, exert duty as seen, groan, discharge canescence loose stool, around cloaca, feather has feces, even there is dead chickling, dead chickling is dissected visible liver enlargement, congested or have striated hemorrhage, gollbladder dilation, containing a large amount of bile.Pulmonary congestion or hemorrhage.The absorption of yolk at its that the course of disease is long is bad, in oils and fats sample or cheesy.On liver, lung, heart, intestinal and muscular stomach, there are yellow downright bad point or tuberosity, when the tuberosity on cardiac muscle increases, heart can be made significantly to be out of shape.Caecum portion expands, and its content has cheesy obstruction.The color and luster kermesinus or pale of kidney, renal tubules and dilatation of ureter, be full of urate.Pullorum Disease is diagnosed as with analysing according to above-mentioned epidemiology.
Choose the ill chickling 180 that 20 ages in days are made a definite diagnosis, 180 ill chickling are divided into three groups at random, be respectively embodiment group 1, embodiment group 2 and matched group, the ill chickling of three groups all without significant difference, has comparability in body weight, the state of an illness etc.Embodiment group 1, embodiment group 2 and matched group use the powder of the injectable powder of the embodiment of the present invention 1, embodiment 2 and conventional medicament to treat respectively; Wherein, injectable powder adopts subcutaneous injection, each 2g, once a day, and injection 6 days continuously; The using method of powder be by powder according in the part by weight conventional feed of 0.2g:37g, feed continuously 6 days; Conventional medicament using method is by oxytetracycline, tetracycline according in the part by weight conventional feed of 0.2g:100g, feeds 6 days continuously.Experimental period is 6 days, takes each group of ill chickling body weight respectively before and after experiment, and period records recovery from illness situation and the death toll of ill chickling, calculates average daily gain and cure rate, and the time of recovery from illness number compares, result as table 1, shown in table 2 and table 3.Wherein, cure: do not occur breathing, dyspnea, arthroncus, walking disorder, limping, spirit is depressed, necking down of bowing, feather is fluffy, and appetite declines, few food or do not eat, shiver with cold of being afraid of cold, often flock together and be crowded together, close one's eyes drowsiness, difficult defecation, exerts duty, groan as seen, discharge canescence loose stool, around cloaca, feather has the symptoms such as feces; Invalid: clinical symptoms is not improved and even increased the weight of or death.
Table 1 is group chickling average weight synopsis respectively
| Group | Sum | Average weight before experiment | Average weight after test | Average daily gain |
| Embodiment group 1 | 60 | 191.3g | 195.1g | 0.63g/d |
| Embodiment group 2 | 60 | 191.1g | 196.7g | 0.93g/d |
| Matched group | 60 | 191.4g | 191.9g | 0.08g/d |
Data from table 1: compared with matched group, use the ill chickling of Drug therapy of the present invention, the chickling that its average weight is treated than traditional therapy exceeds 3.2g and 4.8g respectively, and average daily gain exceeds 0.55g/d and 0.85g/d respectively.
The therapeutic effect synopsis of chickling respectively organized by table 2
| Group | Sum | Recovery from illness number | Invalid number | Cure rate |
| Embodiment group 1 | 60 | 60 | 0 | 100% |
| Embodiment group 2 | 60 | 60 | 0 | 100% |
| Matched group | 60 | 47 | 13 | 78.3% |
Data from table 2: compared with conventional medicament, the medicine of the embodiment of the present invention 1 and 2 has advantage that is evident in efficacy, cheap, that have no side effect in the treatment white scour of chicken.
Known by contrast test: compared with conventional medicament, the pharmaceutical composition of the embodiment of the present invention 1 and 2 has toxic and side effects advantage little, evident in efficacy in the little fowl plague for the treatment of, but also can be good at the normal growth ensureing chickling.
The time comparative example (%) of curing number for 6 days afterwards treated respectively by table 3 respectively group
| Group | Number of cases | 1-2 days | 3-4 days | 5-6 days |
| Embodiment group 1 | 60 | （56）93.3% | （4）6.7% | （0）0% |
| Embodiment group 2 | 60 | （58）96.7% | （2）3.3% | （0）0% |
| Matched group | 47 | （3）6.4% | （7）14.9% | （37）78.7% |
Data from table 3: pharmaceutical composition of the present invention, to the treatment white scour of chicken, relative to conventional medicament on therapeutic effect, has significant improvement, obviously shortens and treats the course for the treatment of.
Model case:
The chickling of 300 20 ages in days of in December, 2014 Taian Shandong poultry smallholder operating, nearly 100 occur breathing, dyspnea, arthroncus, walking disorder, limping, spirit is depressed, necking down of bowing, feather is fluffy, and appetite declines, few food or do not eat, shiver with cold of being afraid of cold, often flock together and be crowded together, close one's eyes drowsiness, difficult defecation, exerts duty, groan as seen, discharge canescence loose stool, around cloaca, feather has the symptoms such as feces.Place is raised immediately by not occurring that the chickling of symptom isolates.Choose 50 ill chickling wherein, start to feed and be added with the feedstuff of the embodiment of the present invention 2 powder, powder is mixed in conventional feed according to 0.2g:37g weight ratio, feed 6 days, within 1st day, ill chickling symptom is obviously improved, and within the 2nd day, 50 chickling are all fully recovered, after continuing to feed 4 days, compared with healthy chick, average weight is substantially identical.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. treat the pharmaceutical composition of the white scour of chicken for one kind, it is characterized in that, described pharmaceutical composition comprises following raw medicinal material: the Radix Pulsatillae, Cortex Phellodendri, Herba Potentillae Discoloris, Poria, Herba polygoni hydropiperis, Radix Sophorae Flavescentis, Herba Violae, Herba Hyperici Patuli, Herba Pteridis Multifidae, Flos Chrysanthemi Indici, Herba Andrographis, Herba cuscutae, geranium, Radix Cirsii Japonici, Massa Medicata Fermentata, Geranium strictipes R. Kunth, Rhizoma Atractylodis, Folium Callicarpae Formosanae, Herba Agrimoniae, Herba Acalyphae, Herba Taraxaci, Radix Puerariae, Flos Capsellae, Caulis Lonicerae, Indigo Naturalis, Cacumen Platycladi, the Rhizoma Atractylodis Macrocephalae, Herba Euphorbiae Humifusae and Semen Arecae.
2. the pharmaceutical composition of the treatment white scour of chicken according to claim 1, is characterized in that, in described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: Radix Pulsatillae 15-35 weight portion, Cortex Phellodendri 12-24 weight portion, Herba Potentillae Discoloris 10-30 weight portion, Poria 15-35 weight portion, Herba polygoni hydropiperis 10-25 weight portion, Radix Sophorae Flavescentis 10-20 weight portion, Herba Violae 10-30 weight portion, Herba Hyperici Patuli 15-35 weight portion, Herba Pteridis Multifidae 12-22 weight portion, Flos Chrysanthemi Indici 13-28 weight portion, Herba Andrographis 12-32 weight portion, Herba cuscutae 13-33 weight portion, geranium 11-21 weight portion, Radix Cirsii Japonici 14-28 weight portion, Massa Medicata Fermentata 12-32 weight portion, Geranium strictipes R. Kunth 10-35 weight portion, Rhizoma Atractylodis 14-34 weight portion, Folium Callicarpae Formosanae 13-36 weight portion, Herba Agrimoniae 14-24 weight portion, Herba Acalyphae 13-36 weight portion, Herba Taraxaci 14-34 weight portion, Radix Puerariae 12-22 weight portion, Flos Capsellae 14-34 weight portion, Caulis Lonicerae 10-27 weight portion, Indigo Naturalis 10-35 weight portion, Cacumen Platycladi 12-32 weight portion, Rhizoma Atractylodis Macrocephalae 14-36 weight portion, Herba Euphorbiae Humifusae 13-33 weight portion and Semen Arecae 10-20 weight portion.
3. the pharmaceutical composition of the treatment white scour of chicken according to claim 1 and 2, it is characterized in that, in described pharmaceutical composition, the ratio of weight and number of each raw medicinal material is: the Radix Pulsatillae 35 weight portion, Cortex Phellodendri 22 weight portion, Herba Potentillae Discoloris 30 weight portion, Poria 33 weight portion, Herba polygoni hydropiperis 20 weight portion, Radix Sophorae Flavescentis 15 weight portion, Herba Violae 25 weight portion, Herba Hyperici Patuli 34 weight portion, Herba Pteridis Multifidae 20 weight portion, Flos Chrysanthemi Indici 26 weight portion, Herba Andrographis 32 weight portion, Herba cuscutae 31 weight portion, geranium 20 weight portion, Radix Cirsii Japonici 28 weight portion, Massa Medicata Fermentata 30 weight portion, Geranium strictipes R. Kunth 35 weight portion, Rhizoma Atractylodis 32 weight portion, Folium Callicarpae Formosanae 36 weight portion, Herba Agrimoniae 24 weight portion, Herba Acalyphae 36 weight portion, Herba Taraxaci 34 weight portion, Radix Puerariae 22 weight portion, Flos Capsellae 28 weight portion, Caulis Lonicerae 12 weight portion, Indigo Naturalis 30 weight portion, Cacumen Platycladi 25 weight portion, the Rhizoma Atractylodis Macrocephalae 35 weight portion, Herba Euphorbiae Humifusae 33 weight portion and Semen Arecae 20 weight portion.
4. the pharmaceutical composition of the treatment white scour of chicken according to any one of claim 1-3, is characterized in that, described pharmaceutical composition also comprises Herba Potentillae Chinensis, Herba Hedyotidis Diffusae, Rhizoma Chiritae Fimbrisepalae and Semen vignae sinensis.
5. the pharmaceutical composition of the treatment white scour of chicken according to any one of claim 1-4, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: Radix Pulsatillae 15-35 weight portion, Cortex Phellodendri 12-24 weight portion, Herba Potentillae Discoloris 10-30 weight portion, Poria 15-35 weight portion, Herba polygoni hydropiperis 10-25 weight portion, Radix Sophorae Flavescentis 10-20 weight portion, Herba Violae 10-30 weight portion, Herba Hyperici Patuli 15-35 weight portion, Herba Pteridis Multifidae 12-22 weight portion, Flos Chrysanthemi Indici 13-28 weight portion, Herba Andrographis 12-32 weight portion, Herba cuscutae 13-33 weight portion, geranium 11-21 weight portion, Radix Cirsii Japonici 14-28 weight portion, Massa Medicata Fermentata 12-32 weight portion, Geranium strictipes R. Kunth 10-35 weight portion, Rhizoma Atractylodis 14-34 weight portion, Folium Callicarpae Formosanae 13-36 weight portion, Herba Agrimoniae 14-24 weight portion, Herba Acalyphae 13-36 weight portion, Herba Taraxaci 14-34 weight portion, Radix Puerariae 12-22 weight portion, Flos Capsellae 14-34 weight portion, Caulis Lonicerae 10-27 weight portion, Indigo Naturalis 10-35 weight portion, Cacumen Platycladi 12-32 weight portion, Rhizoma Atractylodis Macrocephalae 14-36 weight portion, Herba Euphorbiae Humifusae 13-33 weight portion, Semen Arecae 10-20 weight portion, Herba Potentillae Chinensis 10-35 weight portion, Herba Hedyotidis Diffusae 10-25 weight portion, Rhizoma Chiritae Fimbrisepalae 13-31 weight portion and Semen vignae sinensis 10-27 weight portion.
6. the pharmaceutical composition of the treatment white scour of chicken according to any one of claim 1-5, is characterized in that, in described pharmaceutical composition, the parts by weight of each raw medicinal material are: the Radix Pulsatillae 35 weight portion, Cortex Phellodendri 22 weight portion, Herba Potentillae Discoloris 30 weight portion, Poria 33 weight portion, Herba polygoni hydropiperis 20 weight portion, Radix Sophorae Flavescentis 15 weight portion, Herba Violae 25 weight portion, Herba Hyperici Patuli 34 weight portion, Herba Pteridis Multifidae 20 weight portion, Flos Chrysanthemi Indici 26 weight portion, Herba Andrographis 32 weight portion, Herba cuscutae 31 weight portion, geranium 20 weight portion, Radix Cirsii Japonici 28 weight portion, Massa Medicata Fermentata 30 weight portion, Geranium strictipes R. Kunth 35 weight portion, Rhizoma Atractylodis 32 weight portion, Folium Callicarpae Formosanae 36 weight portion, Herba Agrimoniae 24 weight portion, Herba Acalyphae 36 weight portion, Herba Taraxaci 34 weight portion, Radix Puerariae 22 weight portion, Flos Capsellae 28 weight portion, Caulis Lonicerae 12 weight portion, Indigo Naturalis 30 weight portion, Cacumen Platycladi 25 weight portion, the Rhizoma Atractylodis Macrocephalae 35 weight portion, Herba Euphorbiae Humifusae 33 weight portion, Semen Arecae 20 weight portion, Herba Potentillae Chinensis 34 weight portion, Herba Hedyotidis Diffusae 22 weight portion, Rhizoma Chiritae Fimbrisepalae 30 weight portion and Semen vignae sinensis 25 weight portion.
7. the pharmaceutical composition of the treatment white scour of chicken according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
8. the pharmaceutical composition of the treatment white scour of chicken according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:
The first step, Herba Andrographis, Herba cuscutae, geranium, Radix Cirsii Japonici, Massa Medicata Fermentata, Geranium strictipes R. Kunth and Rhizoma Atractylodis are mixed in described ratio, be the dissolve with ethanol of 85% ~ 95% with the determining alcohol of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Flos Capsellae, Caulis Lonicerae, Indigo Naturalis, Cacumen Platycladi, the Rhizoma Atractylodis Macrocephalae, Herba Euphorbiae Humifusae and Semen Arecae are mixed in described ratio, add the ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, again heat decoction 1 ~ 2 hour, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 80 ~ 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.
9. the pharmaceutical composition of the treatment white scour of chicken according to any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is injectable powder, and its preparation method comprises the following steps:
The first step, described raw medicinal material is mixed in proportion, put into super micron mill and be ground into the mixed powder that the micron particles of 0.1 ~ 10 μm of volume average particle size and particle diameter be less than the nano-scale particle composition of 0.1 μm of volume average particle size, described mixed powder powder rate be at least 95%;
Second step, adding relative to the determining alcohol of the quality 3 ~ 5 times of described mixed powder in the mixed powder that the first step obtains is the ethanol of 85% ~ 95%, stirring and dissolving obtains alcoholic solution, alcoholic solution is left standstill 24 ~ 36 hours under the condition of 5 DEG C ~ 10 DEG C, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, concentrated and dry, and put into super micron mill pulverizing 40 ~ 60 minutes at this, the micron particles of acquisition 0.1 ~ 10 μm of volume average particle size and particle diameter are less than the mixed powder of the nano-scale particle composition of 0.1 μm of volume average particle size, the powder rate that obtains of described mixed powder is at least 95%,
3rd step, gets mixed powder 10g ~ 20g that second step obtains, adds propylene glycol 30g ~ 50g, add 200ml water for injection, stirs and makes it dissolve, inject water to 1000ml further, then add 1g ~ 1.5g needle-use activated carbon, fully stir 30 ~ 50 minutes; Decarbonization filtering; With 0.22 ~ 0.24 μm of filtering with microporous membrane; Lyophilization obtains sterilized powder, subpackage embedding.
10. a preparation method for the pharmaceutical composition of the treatment white scour of chicken as described in any one of claim 1-6, is characterized in that, the dosage form of described pharmaceutical composition is powder, and its preparation method comprises the following steps:
The first step, Herba Andrographis, Herba cuscutae, geranium, Radix Cirsii Japonici, Massa Medicata Fermentata, Geranium strictipes R. Kunth and Rhizoma Atractylodis are mixed in described ratio, be the dissolve with ethanol of 85% ~ 95% with the determining alcohol of 3 ~ 5 times relative to the mixture quality obtained, reflux was extracted after 2 ~ 4 hours, filter, obtain the first filtrate; By filtering residue again with the dissolve with ethanol of the determining alcohol 85% ~ 95% of 1 ~ 2 times relative to the mixture quality obtained, reflux was extracted after 1 ~ 2 hour, filtered, obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7 ~ 0.9g crude drug/mL, through the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ~ 95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure removing ethanol, drying is also ground into powder;
Second step, Flos Capsellae, Caulis Lonicerae, Indigo Naturalis, Cacumen Platycladi, the Rhizoma Atractylodis Macrocephalae, Herba Euphorbiae Humifusae and Semen Arecae are mixed in described ratio, add the ethanol of the determining alcohol 85% ~ 95% of 2 ~ 4 times relative to the mixture quality obtained, heating and refluxing extraction 1 ~ 2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, when the extracting solution after remove impurity being evaporated under the condition of 60 DEG C ~ 70 DEG C 60 DEG C, relative density is the mastic of 1.20 ~ 1.23, and the mastic spray dryer after concentrated is dried to powder;
3rd step, mixes surplus stock medical material in described ratio, adds the water dissolution of 2 ~ 4 times relative to the mixture quality obtained, and heating decoction 2 ~ 4 hours, filters; By filtering residue again with the water dissolution of 1 ~ 2 times relative to the mixture quality obtained, again heat decoction 1 ~ 2 hour, filter; Merge the filtrate of twice, concentrating under reduced pressure removing moisture, drying is also ground into powder;
4th step, the powder mixing first step, second step and the 3rd step obtained, is screened into 80 ~ 120 object fine powders subsequently, is dropped in mixing and blending machine by the fine powder of acquisition and stirs, namely obtain powder.
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| CN115957261A (en) * | 2022-12-27 | 2023-04-14 | 中国农业科学院兰州畜牧与兽药研究所 | Pharmaceutical composition for treating or preventing avian enterovirus syndrome and application thereof |
| CN115721678B (en) * | 2022-12-27 | 2024-01-30 | 中国农业科学院兰州畜牧与兽药研究所 | Pharmaceutical composition for treating or preventing necrotic enteritis of chickens and application thereof |
| CN115887546B (en) * | 2022-12-27 | 2024-09-24 | 中国农业科学院兰州畜牧与兽药研究所 | Pharmaceutical composition for resisting coccidium and application |
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