CN104849782B - Based on the large depth of focus artificial lens of human eye residual accommodation power - Google Patents
Based on the large depth of focus artificial lens of human eye residual accommodation power Download PDFInfo
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- CN104849782B CN104849782B CN201510292026.2A CN201510292026A CN104849782B CN 104849782 B CN104849782 B CN 104849782B CN 201510292026 A CN201510292026 A CN 201510292026A CN 104849782 B CN104849782 B CN 104849782B
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- 230000004308 accommodation Effects 0.000 title claims abstract description 11
- 230000003287 optical effect Effects 0.000 claims abstract description 26
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims abstract description 17
- 239000004926 polymethyl methacrylate Substances 0.000 claims abstract description 17
- 239000000463 material Substances 0.000 claims abstract description 12
- 239000013078 crystal Substances 0.000 claims description 12
- 210000001525 retina Anatomy 0.000 claims description 3
- 238000002834 transmittance Methods 0.000 claims description 2
- 201000010041 presbyopia Diseases 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 6
- 210000000695 crystalline len Anatomy 0.000 description 56
- 238000000034 method Methods 0.000 description 4
- 230000004304 visual acuity Effects 0.000 description 4
- 238000012937 correction Methods 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 230000004438 eyesight Effects 0.000 description 3
- 230000002350 accommodative effect Effects 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000012938 design process Methods 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 208000002177 Cataract Diseases 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000001886 ciliary effect Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000004313 glare Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 201000008525 senile cataract Diseases 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B3/00—Simple or compound lenses
- G02B3/02—Simple or compound lenses with non-spherical faces
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1602—Corrective lenses for use in addition to the natural lenses of the eyes or for pseudo-phakic eyes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
- G02B1/041—Lenses
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- Health & Medical Sciences (AREA)
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- Ophthalmology & Optometry (AREA)
- Optics & Photonics (AREA)
- General Physics & Mathematics (AREA)
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- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
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Abstract
A kind of large depth of focus artificial lens based on human eye residual accommodation power. The present invention is a kind of large depth of focus artificial lens of making for material with polymethyl methacrylate (PMMA), can, for substituting the natural lens of presbyopia human eye, realize the rectification of presbyopia. This artificial lens front and rear surfaces is biconvex aspheric surface and circumferentially symmetrical, and diopter is 22D. And artificial lens is divided into optics portion and the loop being connected with optics portion, optic diameter is 4.55mm, and the effect of supporting loop is fixing artificial lens. Choose the object distance scope of 0～4D, optimize artificial lens surface parameter, obtain the structure of large depth of focus artificial lens. Finally the optical property of artificial lens eye is analyzed the large depth of focus performance of checking artificial lens.
Description
Technical Field
The invention belongs to the technical field of vision correction.
Background
In the natural state of the normal human eye, without accommodation, an infinitely distant object is imaged exactly on the retina. When observing a near object, the eye automatically generates an accommodation signal, the ciliary muscle contracts, and the radius of curvature of the lens surface decreases. However, with age, the accommodative ability of the muscles deteriorates and the accommodative ability of the lens gradually decreases, resulting in presbyopia, which can only be imaged clearly at a specific distance.
The most traditional method of correcting presbyopia is frame eyewear. The general frame glasses have specific diopter, only objects at a specific distance (generally, reading distance) can be clearly seen, and other distances are not clear. Meanwhile, in the current treatment of senile cataract, intraocular lens replacement surgery has become a mature and reliable method, and the effect of restoring eyesight can be achieved by implanting an intraocular lens to replace the original crystalline lens. An intraocular lens with large depth of focus is expected to correct presbyopia while restoring vision. Most of the prior intraocular lenses aiming at restoring the continuous object range of human eyes are bifocal intraocular lenses, and the main defects (part of the intraocular lenses can be overcome by a new trifocal design) are that two points far away and two points near can be seen clearly, and the middle part of the intraocular lenses is not clear. In order to overcome the defect, the optical sword intraocular lens appears, and an optical sword element is taken as the intraocular lens and introduced into an eye model, so that the large focal depth performance is realized, but the element is complex to process. In recent years, aspheric artificial crystals have appeared, which realize multi-focus performance by adding proper spherical aberration, but the selection of object distance position cannot meet the reading distance.
Most of the above intraocular lenses for correcting presbyopia have the most significant problem that the existing gullsland-LeGrand eye model is adopted in the design process, and the residual accommodation power of the human eye is not considered. To overcome this problem, the advent of large depth-of-focus intraocular lenses based on the residual accommodation power of the human eye for correcting presbyopia is of paramount importance. However, no relevant report is found on the artificial lens.
Disclosure of Invention
The invention aims to overcome the defects of the existing artificial lens, take the residual adjusting force of actual human eyes into consideration, provide the artificial lens with large focal depth based on the residual adjusting force of the human eyes, improve the optical performance of the artificial lens eyes and realize the correction of presbyopia.
The large focal depth artificial crystal based on the residual accommodation force of human eyes comprises three parts, namely an aspheric surface type of the front surface and the back surface of the artificial crystal, an artificial crystal material and a large focal depth performance; wherein,
1) the aspheric surface type parts of the front and back surfaces specifically include:
the front and back surfaces of the artificial lens are even aspheric surfaces, and the surface shape of the aspheric artificial lens is described as
A above1～a7The even-order aspheric coefficients from 4 th order to 16 th order in sequence, c is the curvature (i.e. the reciprocal of the radius) at the vertex of the aspheric surface, r is the distance from any point on the aspheric surface to the optical axis, and k is the conic coefficient.
2) The material part of the artificial lens specifically comprises:
the material of the optical part of the intraocular lens is polymethyl methacrylate (PMMA), the refractive index of the PMMA is 1.494, the Abbe number of the PMMA is 51.27, and a connecting loop is required to be arranged around the optical part;
3) and the large focal depth performance part specifically comprises:
the large focal depth is realized by selecting an object distance range from infinity to a clear distance of 0.25m, which corresponds to a vergence range of 0-4D.
The specific design content of the large focal depth artificial crystal comprises the following components:
firstly, according to actual needs, a proper artificial lens surface type is selected. In the invention, the front and back surface shapes of the artificial lens are both aspheric surfaces,
a above1～a7The even-order aspheric coefficients from 4 th order to 16 th order in sequence, c is the curvature (i.e. the reciprocal of the radius) at the vertex of the aspheric surface, r is the distance from any point on the aspheric surface to the optical axis, and k is the conic coefficient.
Secondly, the performance requirement of the optical part of the artificial lens is high, namely the visible light transmittance is high and is generally not lower than 90 percent, and the retina can be prevented from being damaged by potential, harmful and non-physiological light with the wavelength of 320-400 nm. The material of the optical part of the artificial lens in the embodiment of the invention is polymethyl methacrylate (PMMA).
Third, the human crystalline lens is an important component of the refractive medium of the eye, bearing about 19D of diopters. The design process of the artificial crystal is set to be 19-24D. The intraocular lens in the embodiment of the invention bears 22D of diopter.
Fourth, intraocular lenses are generally divided into an optic and a loop attached to the optic. The diameter of the optical part is generally about 4.5-6 mm, and the supporting loop is used for fixing the intraocular lens. The diameter of the optical part of the artificial lens in the embodiment of the invention is 4.55 mm.
Fifthly, on the basis of the first four steps, selecting an object distance range of 0-4D, and optimizing to obtain surface parameters of the artificial crystal, such as front and back curvature radius, center/edge thickness, aspheric surface coefficient and the like.
Advantages and advantageous effects of the invention
The method uses Zemax optical design software to optimize the surface type of the artificial crystal and obtain the artificial crystal with large focal depth. The invention has the following functions and advantages:
first, the aspheric surface artificial lens is the surface of the artificial lens which is processed by aspheric surface, so as to avoid glare after operation. The aspheric surface reduces intraocular spherical aberration of the artificial lens and improves the contrast sensitivity of a patient after operation.
Second, Polymethylmethacrylate (PMMA) is a relatively simple polymer structure, which is a hard material that can increase elasticity after special processing. The artificial lens made of PMMA as a material has been applied clinically for more than 60 years, and practice proves that PMMA is an ideal material for manufacturing the artificial lens and has the characteristics of good optical performance, no irritation in eyes, no biodegradation, no obvious degeneration phenomenon and the like.
Thirdly, the intraocular lens adopts 22D diopter which basically accords with the refractive power of the actual human eye lens.
Fourthly, the diameter of the optical part of the artificial lens is 4.55mm, which basically meets the actual requirement of the human eye.
Fifthly, the artificial crystal selects the range of 0-4D object distance, namely from infinity to the photopic distance of 0.25m, and the large focal depth performance of the artificial crystal is realized.
Drawings
Fig. 1 is a perspective view of an intraocular lens according to an embodiment of the present invention, as viewed from the posterior surface of the intraocular lens.
Fig. 2 is a front view of an intraocular lens according to an embodiment of the present invention.
Fig. 3 is a side view of fig. 2.
FIG. 4 is an MTF curve at different object distances.
FIG. 5 is a graph of MTF at spatial frequency 30c/mm for different object distances.
Detailed Description
The details of the large focal depth intraocular lens based on residual accommodation power of human eyes provided by the present invention are further described below with reference to the following specific drawings and embodiments:
fig. 1 is a perspective view of an intraocular lens according to an embodiment of the present invention, as viewed from the posterior surface of the intraocular lens. As shown in fig. 1, a large depth of focus intraocular lens comprises an anterior surface 1 and a posterior surface 2 of the optic, and haptics attached to the optic. The whole artificial lens is circumferentially symmetrical, and the front surface and the rear surface of the optical part are double-convex aspheric surfaces.
Example 1
The front and back surfaces of the intraocular lens are even aspheric surfaces, diopter is 22D, the selected material is PMMA, the refractive index is 1.494, and the Abbe number is 51.27. The surface profile of an aspheric intraocular lens surface can be described as:
a above1～a7The even-order aspheric coefficients from 4 th order to 16 th order in sequence, c is the curvature (i.e. the reciprocal of the radius) at the vertex of the aspheric surface, r is the distance from any point on the aspheric surface to the optical axis, and k is the conic coefficient.
In Zemax optical design software, the aspheric coefficient a is obtained through optimization1～a7As shown in table 1.
TABLE 1 aspherical surface coefficients of intraocular lenses
Through optimization, the aspheric surface artificial lens for realizing the large focal depth (0-4D) is finally designed, the front surface curvature radius is 13.394mm, the center thickness of the rear surface curvature radius of-14.964 mm is 0.599mm, and the edge thickness is 0.282 mm. The front and top views are shown in fig. 2 and 3.
And in the eye model, the Modulation Transfer Function (MTF) and the Visual Acuity (VA) of the 0-4D dioptric range at different positions are analyzed, and the imaging effect of the Modulation Transfer Function (MTF) and the Visual Acuity (VA) are evaluated by using an E diagram. The properties of the obtained aspherical intraocular lens were analyzed as follows:
1) the MTF curves are well balanced for the intraocular lens at 7 different object distance positions, and the best image quality is obtained at near (4D), as shown in fig. 4. The MTF value at the spatial frequency of 30c/mm is higher than 0.47 at different object distances, and reaches more than 0.6 at the reading distance, as shown in FIG. 5.
2) The human eye acutance obtained by the artificial lens under 7 different object distances reaches more than 0.9, and a good correction effect is obtained.
In conclusion, the intraocular lens eye obtains good optical performance in the range of the whole object distance position of 0-4D, and the effect of large focal depth is achieved.
Claims (2)
1. An artificial lens with large focal depth based on residual accommodation force of human eyes is characterized by comprising three parts, namely aspheric surface shapes of the front and back surfaces of the artificial lens, artificial lens materials and large focal depth performance; wherein,
1) the aspheric surface type parts of the front and back surfaces specifically include:
the front and back surfaces of the artificial lens are even aspheric surfaces, and the surface shape of the aspheric artificial lens is described as
Wherein, a1～a7Even-order aspheric coefficients from 4 th order to 16 th order in sequence, c is the curvature (namely the reciprocal of the radius) at the vertex of the aspheric surface, r is the distance from any point on the aspheric surface to the optical axis, and k is a conic coefficient;
2) the material part of the artificial lens specifically comprises:
the material of the optical part of the intraocular lens is polymethyl methacrylate (PMMA), the index of refraction of the PMMA is 1.494, and the Abbe number of the PMMA is 51.27; and requires the attachment tabs to be placed around the optic;
3) and the large focal depth performance part specifically comprises:
the large focal depth is realized by selecting an object distance range from infinity to a clear distance of 0.25m, which corresponds to a vergence range of 0-4D.
2. The intraocular lens with large focal depth based on residual accommodation power of human eye of claim 1, wherein the intraocular lens is specifically designed to include:
firstly, selecting proper artificial lens surface types, setting the front and back surface types of the artificial lens as aspheric surfaces,
wherein, a1～a7Even-order aspheric coefficients from 4 th order to 16 th order in sequence, c is the curvature (namely the reciprocal of the radius) at the vertex of the aspheric surface, r is the distance from any point on the aspheric surface to the optical axis, and k is a conic coefficient;
secondly, the optical part of the artificial lens requires high visible light transmittance, generally not less than 90%, and can ensure that the retina is prevented from being damaged by potential, harmful and non-physiological light with the wavelength of 320-400 nm;
thirdly, setting the intraocular lens to have diopter of 19-24D;
fourthly, the artificial lens is generally divided into an optical part and a loop connected with the optical part, the diameter of the optical part is 4.5-6 mm, and the supporting loop is used for fixing the artificial lens;
fifthly, on the basis of the four steps, selecting an object distance range of 0-4D, and optimizing to obtain surface parameters of the artificial crystal, including front and back curvature radii, center/edge thickness and aspheric coefficients.
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| CN107440818A (en) * | 2016-06-01 | 2017-12-08 | 西安浦勒生物科技有限公司 | A kind of new back room artificial lens based on innovation biocompatibility hydrophobic material |
| FR3056766B1 (en) * | 2016-09-23 | 2018-10-26 | Joel Pynson | INTRAOCULAR LENS WITH EXTENDED FIELD DEPTH |
| CN106491244B (en) * | 2016-12-05 | 2018-12-28 | 南开大学 | Big depth of focus aspherical diffractive type artificial lens |
| CN107468377B (en) * | 2017-07-25 | 2019-06-04 | 南开大学 | It is a kind of for correcting the big depth of focus aspheric intraocular lens of presbyopia |
| CN108814770B (en) * | 2018-04-24 | 2020-09-01 | 南开大学 | Double-area aspheric diffraction type artificial crystal with extended depth of field performance |
| CN115024860B (en) * | 2022-06-09 | 2024-08-23 | 南开大学 | Zonal aspheric intraocular lens with extended focal depth |
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| JP5275030B2 (en) * | 2006-08-31 | 2013-08-28 | Ｈｏｙａ株式会社 | Production method of polythiourethane resin |
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| US7481532B2 (en) * | 2006-02-09 | 2009-01-27 | Alcon, Inc. | Pseudo-accommodative IOL having multiple diffractive patterns |
| RU2501054C2 (en) * | 2008-07-15 | 2013-12-10 | Алькон, Инк. | Accommodative intraocular lens (iol) having toric optical element and extended focal depth |
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| JP5275030B2 (en) * | 2006-08-31 | 2013-08-28 | Ｈｏｙａ株式会社 | Production method of polythiourethane resin |
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| 大焦深人工晶体的设计;饶丰;《中国光学》;20121031;第5卷(第5期);全文 * |
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Effective date of registration: 20210526 Address after: No. 99, Xinxing Road, West District, Binhai New Area Development Zone, Tianjin 300462 Patentee after: TIANJIN CENTURY KANGTAI BIO-MEDICAL ENGINEERING Co.,Ltd. Address before: 300071 Tianjin City, Nankai District Wei Jin Road No. 94 Patentee before: NANKAI University |