CN104799932A - Porous structure bone cement screw design and manufacturing method thereof - Google Patents
Porous structure bone cement screw design and manufacturing method thereof Download PDFInfo
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- CN104799932A CN104799932A CN201510175656.1A CN201510175656A CN104799932A CN 104799932 A CN104799932 A CN 104799932A CN 201510175656 A CN201510175656 A CN 201510175656A CN 104799932 A CN104799932 A CN 104799932A
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- screw
- bone cement
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- structure bone
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- 239000002639 bone cement Substances 0.000 title claims abstract description 65
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 claims abstract description 10
- 239000002904 solvent Substances 0.000 claims abstract description 7
- 238000005516 engineering process Methods 0.000 claims abstract description 6
- 238000000149 argon plasma sintering Methods 0.000 claims abstract description 4
- 238000002360 preparation method Methods 0.000 claims description 17
- 239000000463 material Substances 0.000 claims description 10
- 239000007787 solid Substances 0.000 claims description 7
- 239000004677 Nylon Substances 0.000 claims description 6
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 6
- 229920001778 nylon Polymers 0.000 claims description 6
- 238000004064 recycling Methods 0.000 claims description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 4
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims description 4
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 3
- 239000004698 Polyethylene Substances 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 235000019253 formic acid Nutrition 0.000 claims description 3
- -1 polyethylene Polymers 0.000 claims description 3
- 229920000573 polyethylene Polymers 0.000 claims description 3
- 210000000988 bone and bone Anatomy 0.000 abstract description 9
- 239000012620 biological material Substances 0.000 abstract description 8
- 208000027418 Wounds and injury Diseases 0.000 abstract description 4
- 230000006378 damage Effects 0.000 abstract description 4
- 208000014674 injury Diseases 0.000 abstract description 4
- 238000005266 casting Methods 0.000 abstract description 3
- 238000011084 recovery Methods 0.000 abstract description 3
- 206010017076 Fracture Diseases 0.000 abstract 1
- 208000010392 Bone Fractures Diseases 0.000 description 12
- 239000000843 powder Substances 0.000 description 3
- 229920002302 Nylon 6,6 Polymers 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000010146 3D printing Methods 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000015220 hamburgers Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
- A61B17/86—Pins or screws or threaded wires; nuts therefor
- A61B17/866—Material or manufacture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00004—(bio)absorbable, (bio)resorbable or resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B2017/00526—Methods of manufacturing
Landscapes
- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
The invention relates to a porous structure bone cement screw design and a manufacturing method thereof. The method comprises the following steps that (1) a three-dimensional model of a screw is designed, then, a model of a screw mold is exported, and next, layered slicing software is used for carrying out layered slicing on the model according to the set thickness; (2) the screw mold is printed out through a laser sintering technology; (3) in a vacuum casting machine, bone cement is cast in a vacuum way in the screw mold; (4) the bone cement is taken out from the vacuum casting machine after being completely cured, and the still standing is carried out for a period of time, so that the mold is uniformly cooled in the air; (5) the screw mold filled with the bone cement is solved into a solvent so that the screw mold is dissolved, and finally, a formed porous bone cement screw is obtained. The porous structure bone cement screw design and the manufacturing method solve the problem that bone cement biological materials cannot be used for preparing product parts, and the application range of the biological materials is enlarged. The invention first provides the porous structure design of a medical screw, the fast recovery of the fracture bone can be promoted, and the secondary injury to the bone caused by the traditional medical screw after the operation is avoided.
Description
Technical field
The invention belongs to medical instruments field, be specifically related to a kind of internal fixtion loose structure biomaterial screw for bone surgery and preparation method thereof.
Background technology
The history of fractures is very long.Within 1902, in the mummy that Egyptian Naga ed Der is unearthed, found fractures evidence the earliest, its time is B.C. 300 years.1852, Dutch doctor Mathijsen brought into use plaster bandage to be fixed suffering limb.In 130 ~ 200 years Christian eras, in the early stage works of Galen, there is description fracture being carried out to traction therapeutic.Start in the middle of the 19th century the traction therapeutic continued of fracturing.1767, Gooch described functional support.1875, Franz Konig reported first used the fixing fracture of screw.1886, Carl Hansmann used the fixing fracture of metal bone fracture plate screw in hamburger reported first.1907, AlbinLambotte describes first " synthetism " (Osteosynthesis) this new term.In the same year, FritzSteinmann brings into use Stein-mann to follow closely treatment fracture.Nineteen twenty-seven, Martin Kirschner brings into use Kirschner pin (Kirschner wire) to treat fracture.1938, Robert Danis used screw tap and cortical bone screw to fix fracture two cortex of pressurizeing.Nineteen thirty-nine, Gerhard Kintscher reported first uses V-arrangement intramedullary nail treatment fracture, and uses in a large number in the Russo-Finnish War 1918-20.Nineteen forty-one, the Kintscher intramedullary pin (percussopunctator) in cloverleaf pattern cross section emerges.Nineteen forty-two, Gerhard Kintscher has published " Technique ofIntramedullary Nailing " book.Nineteen fifty, Robert Danis has published " theory and practice of fracture fixation ".1958, AO group of Switzerland set up.Nineteen sixty, AO proposes four basic principles of fractures first: anatomical reduction and reconstruction; Osteocomma pressurization is with strong fixing; Retain the blood fortune of bone; Early stage pain-free mobility.
Therefore, Medical screw is applied very extensive in modern fracture operation.But, due to conventional titanium alloy Medical screw, its elastic modelling quantity differs comparatively large and poor with human skeleton histocompatibility with true skeleton, be easy to Post operation and occur that stress is concentrated and finally causes coming off or the secondary injury of skeleton of implant, even occur that screw is through corrosion in body fluid, get rusty, finally toxic and side effects is produced to human body.
Summary of the invention
Object of the present invention provide a kind of loose structure bone cement screw design and preparation method thereof, to solve the problems of the technologies described above.
For achieving the above object, the present invention adopts following technical scheme:
A preparation method for loose structure bone cement screw, comprises the following steps:
1) threedimensional model of screw is gone out according to the structural design of loose structure bone cement screw, the model of screw mould of reentrying; Then derived by the model of screw mould, recycling hierarchy slicing software, carries out hierarchy slicing to model by setting thickness, and section file comprises laser beam flying track, slice thickness and support compactedness information;
2) screw mould is printed by laser sintering technology;
3) in vacuum pouring machine, vacuum pouring bone cement in screw mould;
4) after bone cement being solidified completely, take out from vacuum pouring machine, leave standstill a period of time, make the even air cooling of mould;
5) the screw mould having poured into bone cement is soaked in solvent screw mould is dissolved; Finally, the porous bone cement screw be shaped is obtained.
Preferably, step 1) in utilize CAD software, the threedimensional model of screw is gone out according to the structural design of loose structure bone cement screw, the model of screw mould is obtained again by boolean's reducing, then derived with STL form by the model of screw mould, recycling hierarchy slicing software, carries out hierarchy slicing to STL model by setting thickness, form is cli form, and section file comprises laser beam flying track, slice thickness and support compactedness information.
Preferably, step 2) in laser sintered selected printed material heat distortion temperature higher than 100 DEG C.
Preferably, step 2) in laser sintered adopted printed material be nylon, polyethylene or Merlon.
Preferably, step 3) in cast before vacuum defoamation process is carried out to the bone cement prepared; Build and rear evacuation, deaeration process are carried out to mould.
Preferably, step 5) described in solvent be formic acid, dimethylbenzene or chloroform.
Preferably, described loose structure bone cement screw comprises the porous support body, solid cylindrical body and the threaded body that connect successively.
Preferably, the length of threaded body is 30% ~ 80% of whole loose structure bone cement screw.
Preferably, the porosity of porous support body is 30% ~ 80%.
Preferably, solid cylindrical body length should be more than or equal to 2mm.
A kind of loose structure bone cement screw prepared by preparation method of loose structure bone cement screw.
Relative to prior art, the present invention has following beneficial effect: a kind of loose structure bone cement screw prepared by bone-cement biological material of the present invention, main in fracture operation for the connection of fractured bone and fixing head, to reduce the injury of operation to skeleton, the loose structure of its rear end enables the breaking part of skeleton heal better.Its preparation method has the following advantages: 1) solve the problem that cannot utilize bone-cement biological material preparing product part, expand the range of application of biomaterial.2) loose structure taking the lead in proposing Medical screw designs, and promotes the fast quick-recovery of skeleton of fracture, avoids conventional medical screw after surgery to the secondary injury of skeleton.3) propose the method utilizing bone cement material to prepare first, and solve and cannot directly utilize 3D printing technique to be shaped the problem of bone cement screw.
Accompanying drawing explanation
Fig. 1 is the structural representation of a kind of loose structure bone cement screw of the present invention;
Fig. 2 is the die drawing preparing loose structure bone cement screw.
Detailed description of the invention
Below in conjunction with specific embodiment, loose structure bone cement screw of the present invention is further described.
As shown in Figure 1, a kind of loose structure bone cement screw of the present invention, comprises the porous support body 1, solid cylindrical body 2 and the threaded body 3 that connect successively.For making porous support body 1 and threaded body 3 combine closely, middle solid cylindrical body 2 plays transitional function, and its L/D ratio example should be at least 1:1.And the length of threaded body is 30% ~ 80% of whole loose structure bone cement screw; The porosity of porous support body 1 is 30% ~ 80%.Solid cylindrical surface is smooth, and for ensureing and porous support, the bond strength of threaded portion, its length should be at least 2mm.
Refer to shown in Fig. 2, the preparation method of a kind of loose structure bone cement screw of the present invention comprises the following steps:
1) CAD software is first utilized, the threedimensional model of screw is gone out according to the structural design of loose structure bone cement screw, the model of screw mould is obtained again by boolean's reducing, then derived with STL form by the model of screw mould, recycling hierarchy slicing software, carries out hierarchy slicing to STL model by setting thickness, form is cli form, section file comprises laser beam flying track, slice thickness, supports compactedness information.
2) (printed material selects the resistance to material being greater than 100 DEG C, ensures in follow-up whole bone cement solidification heating process indeformable to print screw mould by laser sintering technology (SLS); Recommend the material adopted to be nylon66 fiber-E830 powder, polyethylene or Merlon, the heat distortion temperature of nylon66 fiber-E830 powder is at about 250 DEG C).After shaping terminates, wait screw mold temperature to be formed to drop to room temperature, remove the support of unnecessary nylon powder and interpolation on printout, screw mould can be obtained.
3) in vacuum pouring machine, according to bone cement operation instruction, bone cement and water are proportioned, stirring is mixed well, and then places evacuation in a vacuum chamber, carries out deaeration process.After wait is greater than 7 minutes, thick bone cement is poured in screw mould at leisure, and casting process not interruptible price, until be poured, the duration of pouring must not more than 10 minutes.Then, evacuation is carried out to screw mould, deaeration process.About wait is after 16 minutes, and bone cement solidifies in a mold completely.
4) mould after cast bone cement is taken out from vacuum pouring machine, leave standstill a period of time, make the even air cooling of mould, to ensure that bone cement solidifies completely.
5) the nylon mould having poured into bone cement is immersed in formic acid solvent (for nylon material, the corresponding solvent of other material selection), makes nylon mould and support rapid solution.Finally, the porous bone cement screw be shaped is obtained.
Porous bone cement screw of the present invention in use, uses the specific purpose tool matched with screw head formation, tightens screw body.Realize the combination of bone and fixing by screw thread, and screw thread realize bone combination and fixing after, the loose structure of screw is convenient to the recovery of osseous tissue in screw and growth.Like this, just avoid because conventional entity metallic screw hinders osseous tissue to recover and the problem of poor biocompatibility, and overcome bone-cement biological material and cannot directly be used for printing or the problem of machining, expand the biomaterial scope of application.
Claims (10)
1. a preparation method for loose structure bone cement screw, is characterized in that, comprises the following steps:
1) threedimensional model of screw is gone out according to the structural design of loose structure bone cement screw, the model of screw mould of reentrying; Then derived by the model of screw mould, recycling hierarchy slicing software, carries out hierarchy slicing to model by setting thickness, and section file comprises laser beam flying track, slice thickness and support compactedness information;
2) screw mould is printed by laser sintering technology;
3) in vacuum pouring machine, vacuum pouring bone cement in screw mould;
4) after bone cement being solidified completely, take out from vacuum pouring machine, leave standstill a period of time, make the even air cooling of mould;
5) the screw mould having poured into bone cement is soaked in solvent screw mould is dissolved; Finally, the porous bone cement screw be shaped is obtained.
2. the preparation method of a kind of loose structure bone cement screw according to claim 1, it is characterized in that, step 1) in utilize CAD software, the threedimensional model of screw is gone out according to the structural design of loose structure bone cement screw, the model of screw mould is obtained again by boolean's reducing, then the model of screw mould is derived with STL form, recycling hierarchy slicing software, by setting thickness, hierarchy slicing is carried out to STL model, form is cli form, and section file comprises laser beam flying track, slice thickness and support compactedness information.
3. the preparation method of a kind of loose structure bone cement screw according to claim 1, is characterized in that, step 2) in laser sintered selected printed material heat distortion temperature higher than 100 DEG C.
4. the preparation method of a kind of loose structure bone cement screw according to claim 1, is characterized in that, step 2) in laser sintered adopted printed material be nylon, polyethylene or Merlon.
5. the preparation method of a kind of loose structure bone cement screw according to claim 1, is characterized in that, step 3) in cast before vacuum defoamation process is carried out to the bone cement prepared; Build and rear evacuation, deaeration process are carried out to mould.
6. the preparation method of a kind of loose structure bone cement screw according to claim 1, is characterized in that, described loose structure bone cement screw comprises the porous support body, solid cylindrical body and the threaded body that connect successively.
7. the preparation method of a kind of loose structure bone cement screw according to claim 5, is characterized in that, step 5) described in solvent be formic acid, dimethylbenzene or chloroform.
8. the preparation method of a kind of loose structure bone cement screw according to claim 6, is characterized in that, the length of threaded body is 30% ~ 80% of whole loose structure bone cement screw; Solid cylindrical body length is more than or equal to 2mm.
9. the preparation method of a kind of loose structure bone cement screw according to claim 6, is characterized in that, the porosity of porous support body is 30% ~ 80%.
10. the loose structure bone cement screw prepared by preparation method of a kind of loose structure bone cement screw according to any one of claim 1 to 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510175656.1A CN104799932B (en) | 2015-04-14 | 2015-04-14 | Porous structure bone cement screw design and manufacturing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510175656.1A CN104799932B (en) | 2015-04-14 | 2015-04-14 | Porous structure bone cement screw design and manufacturing method thereof |
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| Publication Number | Publication Date |
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| CN104799932A true CN104799932A (en) | 2015-07-29 |
| CN104799932B CN104799932B (en) | 2017-04-26 |
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| CN201510175656.1A Expired - Fee Related CN104799932B (en) | 2015-04-14 | 2015-04-14 | Porous structure bone cement screw design and manufacturing method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106108998A (en) * | 2016-07-25 | 2016-11-16 | 南京医科大学第附属医院 | A kind of braided steel wire inner core antibiotic-loaded bone cement intramedullary pin and preparation method thereof and making mould |
| CN107981926A (en) * | 2017-09-20 | 2018-05-04 | 北京航空航天大学 | The new resistance to plucking based on increases material manufacturing technology goes out pedicle nail |
| CN109044519A (en) * | 2018-09-14 | 2018-12-21 | 北京爱康宜诚医疗器材有限公司 | pedicle screw |
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| JPH0751292A (en) * | 1993-08-16 | 1995-02-28 | Yoshihiro Kishigami | Bone screw left in bone |
| CN1270859A (en) * | 2000-04-29 | 2000-10-25 | 华中理工大学 | Fast metal mold producing technology |
| WO2006127392A2 (en) * | 2005-05-26 | 2006-11-30 | Amedica Corporation | Osteoconductive spinal fixation system |
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2015
- 2015-04-14 CN CN201510175656.1A patent/CN104799932B/en not_active Expired - Fee Related
Patent Citations (10)
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106108998A (en) * | 2016-07-25 | 2016-11-16 | 南京医科大学第附属医院 | A kind of braided steel wire inner core antibiotic-loaded bone cement intramedullary pin and preparation method thereof and making mould |
| CN107981926A (en) * | 2017-09-20 | 2018-05-04 | 北京航空航天大学 | The new resistance to plucking based on increases material manufacturing technology goes out pedicle nail |
| CN109044519A (en) * | 2018-09-14 | 2018-12-21 | 北京爱康宜诚医疗器材有限公司 | pedicle screw |
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| Publication number | Publication date |
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| CN104799932B (en) | 2017-04-26 |
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