CN104777012B - A kind of disposable pretreatment self-distroyable disposable urine liquid sampler and preparation method thereof - Google Patents
A kind of disposable pretreatment self-distroyable disposable urine liquid sampler and preparation method thereof Download PDFInfo
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- CN104777012B CN104777012B CN201510176247.3A CN201510176247A CN104777012B CN 104777012 B CN104777012 B CN 104777012B CN 201510176247 A CN201510176247 A CN 201510176247A CN 104777012 B CN104777012 B CN 104777012B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
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- General Health & Medical Sciences (AREA)
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- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a kind of disposable pretreatment self-distroyable disposable urine liquid sampler and preparation method thereof.The sampler is dust cap (1) (as shown in drawings), screw terminal (2), sampling pipe (3), porous microvesicle sampling column (4), the sillicon rubber blocking (5) for being connected with flat wood pull bar (7) and fixing nut (6) connection composition.Present invention collection urine concentration easy to operate, safe and healthy, ensureing urine antibody (antigen) when sterile, guarantee uniqueness, special construction and function can preserve one week at normal temperatures is more than the 90% of crude urine, ensure that the accuracy of urine antibody (antigen) detection and the convenience of self-test and the right of privacy that mailing anonymity is examined.New method is provided for urine capture and storage.
Description
Technical field
The present invention relates to a kind of urine liquid sampler and preparation method thereof, more particularly to a kind of disposable pretreatment self-destruction
Type, the urine liquid sampler that urinary fractions are stable, use and store simplicity can be kept within a certain period of time.
Background technology
Much lower than blood antibody concentration of antibody concentration in urine, various antibody total concentrations are blood antibody concentrations in urine
1/3000, the concentration of wherein HIV antibody is just lower.Urine mainly contains water, inorganic salts, urea and uric acid and micro flesh
Acid anhydride, acid mucopolysaccharide, oxalic acid and diet and the metabolite for taking in medicine, the also material such as extremely micro antibody antigen,
Wherein inorganic salts are suitable with blood plasma, urea and uric acid are blood plasma respectively 60 times and 11 times.Urine departs from human body, temperature and pH value
Change makes urine unstable, easily forms flocculation sediment, reduces the concentration of antibody (antigen) in urine.So keep the steady of urine
Qualitative is to ensure that urine constituent analysis and urine antibody (antigen) detect the accurate first step.
The urine of most people contains a small amount of bacterium, and it is not sterile behaviour to be collected urine using urine cup and collected process
Make, the urine collected in test tube is not easy to preserve for a long time with bacterium.The method of " urine cup collection-Restored in test tube " is easily by dirt
Dye and easily mark disorder." disposable pretreatment self-distroyable disposable urine liquid sampler " solves the above problems, easy to operate, hygienic peace
Entirely, ensure that urine is sterile, ensures uniqueness, ensure that the accuracy of urine antibody (antigen) detection and the convenience of self-test, be
Urine capture and storage provide new method.
The content of the invention
In order to when overcoming collection and storage urine carry disease germs unstability with composition the problem of, the present invention provide it is a kind of once
Property pretreatment self-distroyable disposable urine liquid sampler and preparation method thereof.The sampler successively by dust cap 1, screw terminal 2, sampling pipe 3,
Porous microvesicle sampling column 4, the sillicon rubber blocking 5 for being connected with pull bar 7 and fixing nut 6 connection composition, the porous microvesicle sampling column 4 by
Pretreated porous microvesicle material is made, and the pretreatment is to pre-process porous microvesicle using albumen or surfactant closing
Material, the porous microvesicle material after closing is further handled using antiseptic, antifungal agent solution afterwards, is eventually fabricated porous micro-
Steep sampling column 4.The porous microvesicle material for can absorbent solution, compressible and high resilience, with urine composition reaction
Macromolecule spongy material, the micro-pore diameter size of this porous microvesicle material is between one micron to one millimeter.Flat wood pull bar 7
It is fixedly connected with the gluing of sillicon rubber blocking 5, the flat wood pull bar 7 self-destruction and is numbered beneficial to spraying to be easy to fracture.The He of sampling pipe 3
It is coated with and is identically numbered on pull bar 7, guarantee takes urine and the homogeneity of person under inspection.
Technical scheme is used by the present invention solves the technical problem：
A kind of urine liquid sampler of disposable pretreatment self-distroyable disposable, the sampler include sampling head (2), sampling pipe (3)
And pumping part, wherein the sampling head (2) is located at the front end of the sampling pipe (3), successively by dust cap (1), sampling head
(2), porous microvesicle sampling column (4) is located at sampling pipe (3), porous microvesicle sampling column (4), the suction in the sampling pipe (3)
Part is arranged on the end connection composition of the sampling pipe (3), and the porous microvesicle sampling column (4) is by pretreated porous micro-
Foam material is made, and the pretreatment is to pre-process porous microvesicle material using albumen or surfactant closing, afterwards using anti-
Microbial inoculum, antifungal agent solution further handle the porous microvesicle material after closing, are eventually fabricated porous microvesicle sampling column (4).
A kind of method for the urine liquid sampler for preparing disposable pretreatment self-distroyable disposable, it is characterised in that：Choosing first can
Absorb urine and the compressible and flexible not macromolecule spongy material with the reaction of urine composition is as porous microvesicle
Sampling column making material；Then the macromolecule spongy material is pre-processed with albumen or surfactant closing, to keep urinating
The activity of middle antibody；Afterwards the spongy material of the macromolecule after closing is further handled using antiseptic, antifungal agent solution
Material surface is suitable for longer-term storage of urine sample；It is by the pretreated spongy material cutting of more macromolecules further
Suitable dimension obtains porous microvesicle sampling column；Obtained porous microvesicle sampling column is encased in sampler tube, finally sampled
The front end of pipe installs sampling head, and pumping part is installed in the rear end of sampling pipe.
Further preferred porous microvesicle material is being capable of absorbent solution, compressible and high resilience, not anti-with urine composition
The macromolecule spongy material answered.
The micro-pore diameter size of the further preferred porous microvesicle material is between one micron to one millimeter.
The further preferred pumping part is the sillicon rubber blocking 5 with pull bar 7.
The further preferred pull bar 7 is fixedly connected with the gluing of sillicon rubber blocking 5.
The further preferred pull bar 7 is flat wood pull bar 7.
The further preferred pull bar 7 is made up of the material for being easy to fracture.
The further preferred pull bar 7 is made up of the material beneficial to coding.
The further preferred pull bar 7 is fixedly connected with the gluing of sillicon rubber blocking 5, the pull bar 7 for be easy to fracture self-destruction and
It is made beneficial to the material of spraying numbering.
Further preferred described one end of sampling head 2 carries dust cap 1.
The further preferred sampling head 2 is screw terminal 2.
Further preferably described urine liquid sampler includes fixed component, and the fixed component is easy to fix pumping part
In the end of sampling pipe 3.
The further preferred fixed component is fixing nut 6, and the pumping part is the sillicon rubber blocking 5 with pull bar 7.
The further preferred fixing nut 6 is tightened in the rear end of sampling pipe 3 through pull bar 7.
The further preferred fixing nut 6 is the fixing nut 6 with flat hole, and the pull bar 7 is flat pull bar.
The further preferred pull bar 7 is the wooden pull bar of flat, and the fixing nut 6 with flat hole is wooden through flat
Pull bar 7 is tightened in the rear end of sampling pipe 3.
It is coated with and is identically numbered on the further preferred sampling pipe 3 and pumping part, guarantee takes urine and examined
The homogeneity of person.
The further preferred pumping part is the sillicon rubber blocking 5 with pull bar 7, is sprayed on the sampling pipe 3 and pull bar 7
It is identically numbered, guarantee takes urine and the homogeneity of person under inspection.
Still more preferably a kind of disposable pretreatment self-distroyable disposable urine liquid sampler, the sampler is molded anti-by polyethylene
Dirt cap, sampling pipe, porous microvesicle sampling column, sillicon rubber blocking and flat wood pull bar composition.Sampling pipe top screw terminal has hole, sampling
Be porous microvesicle sampling column inside pipe, this porous microvesicle sampling column by can absorbent solution, compressible and high resilience, not with urine
The macromolecule spongy material of liquid composition reaction is made.The micro-pore diameter size of this porous microvesicle sampling column is at one micron to a milli
Between rice；Through keeping the activity of the material such as antibody in urine with albumen or surfactant closing pretreatment, and using antiseptic,
Antifungal agent solution pre-processes porous microvesicle sampling column material surface and is suitable for longer-term storage of urine sample.Have inside sampling pipe
Sillicon rubber blocking is connected with the wooden pull bar of flat.Air is discharged when wooden pull bar pushes away the porous microvesicle sampling column of silica gel plug forward compression,
Immerse urine on sampling pipe top, and pull wood pull bar drives silica gel plug backward to suck urine in porous microvesicle sampling column, into straight
In microvesicle between one micron to one millimeter of footpath.Urine is absorbed into the microvesicle of porous microvesicle sampling column, and being relatively isolated can not
Outflow, makes liquid phase be easy to store and transport solidification.Microvesicle wall is the hydrophobic structure of confining surface so that its surface
It is unable to adhesion protein and makes water-soluble substances in urine be difficult to precipitate, the microvesicle environment of relative closure make it that urine ph values are stable,
Microvesicle wall is adsorbed with antibacterial material and keeps urine sterile, and the concentration of antibody in urine (antigen) can so kept in storage
It is stable.Sampling pipe back-end closure closes sampling pipe leading portion by silica gel plug after finally covering sampling pipe leading portion with dust cap.Will be flat
Shape pull bar (being not restricted to as wood pull bar, any to be easy to fracture self-destruction and the material beneficial to spraying numbering is suitable for) neat root fracture
After send to inspection or be transferred to other unit inspection.Sampling pipe after urine capture is during storage, and urine is in relative closure
Environmental Water is difficult to evaporate, and cumulative volume is constant, ensure that antibody (antigen) concentration is constant.Sampler and can self-destruction wood draw
Be coated with to be identically numbered on bar and ensure that the numbering for lifting section wooden pull bar that urine detection result and person under inspection hold is consistent, ensure by
The right of privacy of inspection person.
The beneficial effects of the invention are as follows：The above-mentioned sampler for including porous microvesicle sampling column, collection urine is easy to operate, defends
Raw safety, ensure that urine is sterile, ensure that uniqueness, special construction and function can preserve one week at normal temperatures, urinating during detection
The concentration of humoral antibody (antigen) is substantially suitable with crude urine, ensure that the accuracy of urine antibody (antigen) detection and the facility of self-test
Property and be transferred to other unit inspection uniqueness and the right of privacy.New method is provided for urine capture and storage.
Brief description of the drawings
The present invention is further described with reference to the accompanying drawings and examples.
Fig. 1 is sampler profile, 1. dust caps in figure, 2. screw terminals, 3. sampling pipes, 4. porous microvesicle sampling columns, 5.
Sillicon rubber blocking, 6. fixing nuts, 7. flat wood pull bars.
Fig. 2 is sampling pipe profile, 1. sampling pipes in figure, 2. screw-sockets.
Embodiment
1st, the structure snd size of part：
(1) dust cap：Long 54mm, top external diameter 11mm, internal diameter 11mm, openend external diameter 13mm, internal diameter 11mm, wall thickness
1mm。
(2) screw terminal：Long 14mm, top external diameter 8mm, inside there is diameter 2mm holes, a long 10mm in hole, and openend external diameter 11mm is interior
Footpath 10mm, inside there are screw thread long 4mm, pitch 0.5mm.
(3) sampling pipe：Long 80mm, external diameter 10mm, internal diameter 8mm, there are screw thread long 5mm, pitch 0.5mm outside both ends,
(4) porous microvesicle sampling column：Long 50mm, diameter 6mm, high density macromolecule cavernous transformation post.
(5) sillicon rubber blocking：There are flat groove long 10mm, wide 1.5mm in long 15mm, diameter 7mm, one end.Rise in elongatedness direction
Three garden is stupefied, stupefied high 0.8mm, stupefied wide 1mm, and spacing 4mm, first stupefied apart from top 3mm.
(6) fixing nut：Long 14mm, top external diameter 10mm, inside there is an insertion flat long 10mm in hole, flat hole section
Long 6mm, wide 2mm.Openend external diameter 11mm, internal diameter 10mm, inside there are screw thread long 4mm, pitch 0.5mm.
(7) flat wood pull bar：Long 100mm, wide 6mm, thick 1.5mm, one end are circle, and one end is straight.
2nd, preparation method
The flat end of flat wood pull bar 7 is fixedly connected with the groove gluing of sillicon rubber blocking 5.Screw terminal 2 is tightened in sampling
On the front end of pipe 3, porous microvesicle sampling column 4 is put into sampling pipe 3, then the sillicon rubber blocking 5 for being connected with flat wood pull bar 7 is filled in,
Fixing nut 6 with flat hole is tightened in the rear end of sampling pipe 3 through flat wood pull bar 7.In sampling pipe 3 and flat wood pull bar
Spray and be identically numbered on 7 big face.Porous microvesicle sampling column 4 is divided to immerse within 2 hours every time for 2 times and (mainly contained with bacteriostatic agent
Have sodium azide) antimicrobial fluid and confining liquid (mainly containing 0.01M PBS cushioning liquid, pH7.2,0.1% calf serum) in,
After room temperature is placed 2 hours respectively, antimicrobial fluid and confining liquid are discharged, flat wood pull bar 7 is retracted, is put into sampler, screws on fixation
Nut 6, dust cap 1 is covered, be finished product.
3rd, urine capture method
The dust cap 1 of self-distroyable disposable urine liquid sampler front end is opened, flat wood pull bar 7 and silica gel plug 5 are pushed away forward, compression is adopted
Sample post discharges air, and screw terminal 2 and the top of sampling pipe 3 are immersed urine, and pull flat wood pull bar 7 and silica gel plug 5 will be urinated backward
Liquid is sucked in porous microvesicle sampling column 4, covers tightly dust cap 1.Anonymous inspection will be sent to after 7 neat root fracture of flat wood pull bar.Examined
Person, which retains, sprays numbered half wood pull bar.This is numbered for searching examining report.After sampling, room temperature preservation.
Claims (12)
- A kind of 1. urine liquid sampler of disposable pretreatment self-distroyable disposable, it is characterised in that：The sampler include sampling head (2), Sampling pipe (3) and pumping part, wherein the sampling head (2) is located at the front end of the sampling pipe (3), porous microvesicle sampling column (4) it is located in the sampling pipe (3), the pumping part is arranged on the ends of the sampling pipe (3), the porous microvesicle sampling Post (4) is made up of pretreated porous microvesicle material, and the micro-pore diameter size of the porous microvesicle material is at one micron to one Between millimeter, the pretreatment is to pre-process porous microvesicle material using albumen or surfactant closing, afterwards using antibacterial Agent, antifungal agent solution further handle the porous microvesicle material after closing, are eventually fabricated porous microvesicle sampling column (4), wherein It is coated with and is identically numbered on the sampling pipe (3) and pumping part, guarantee takes urine and the homogeneity of person under inspection, described to take out Suction part is the sillicon rubber blocking (5) with pull bar (7).
- 2. the urine liquid sampler of disposable pretreatment self-distroyable disposable according to claim 1, it is characterised in that the sampling pipe (3) and it is coated with and is identically numbered on pull bar (7), guarantee takes urine and the homogeneity of person under inspection.
- 3. the urine liquid sampler of disposable pretreatment self-distroyable disposable according to claim 1, it is characterised in that porous microvesicle material Expect for can absorbent solution, compressible and high resilience, with urinary fractions reaction macromolecule spongy material.
- 4. the urine liquid sampler of disposable pretreatment self-distroyable disposable according to claim 1, it is characterised in that：The pull bar (7) it is fixedly connected with sillicon rubber blocking (5) gluing.
- 5. the urine liquid sampler of disposable pretreatment self-distroyable disposable according to claim 1, it is characterised in that：The pull bar (7) it is made up of the material for being easy to fracture, the pull bar (7) is made up of the material beneficial to coding, the pull bar (7) and sillicon rubber blocking (5) gluing is fixedly connected, and described sampling head (2) one end carries dust cap (1), and the sampling head (2) is screw terminal, described urine Liquid sampler includes fixed component, and the fixed component is easy to pumping part being fixed on the end of sampling pipe (3), the fixation Part is fixing nut (6), and the fixing nut (6) is tightened in the rear end of sampling pipe (3) through pull bar (7).
- 6. the urine liquid sampler of disposable pretreatment self-distroyable disposable according to claim 5, it is characterised in that：The fixed spiral shell Female (6) are the fixing nut (6) with flat hole, and the pull bar (7) is the wooden pull bar of flat, the fixation with flat hole Nut (6) is tightened in the rear end of sampling pipe (3) through flat wood pull bar (7).
- A kind of 7. method for the urine liquid sampler for preparing the disposable pretreatment self-distroyable disposable described in claim 1, it is characterised in that： Urine and the compressible and flexible not macromolecule spongy material with urinary fractions reaction can be absorbed by choosing first As porous microvesicle sampling column making material, the macromolecule spongy material micro-pore diameter size one micron to one millimeter it Between；Then the macromolecule spongy material is pre-processed with albumen or surfactant closing, to keep the activity of antibody in urinating； Afterwards using antiseptic, antifungal agent solution further handle closing after the spongy material surface of the macromolecule be suitable for compared with Long-term storage of urine sample；Further the pretreated spongy material cutting of more macromolecules is obtained for suitable dimension more Hole microvesicle sampling column (4)；Obtained porous microvesicle sampling column (4) is encased in sampling pipe (3), finally in sampling pipe (3) Front end installs sampling head (2), and pumping part is installed in the rear end of sampling pipe (3), wherein the pumping part is with drawing The sillicon rubber blocking (5) of bar (7), methods described are additionally included in spray on the sampling pipe (3) and pumping part and are identically numbered, and protect Card takes urine and the homogeneity of person under inspection.
- 8. the method for the urine liquid sampler of the disposable pretreatment self-distroyable disposable of preparation according to claim 7, it is characterised in that Spray and be identically numbered on the sampling pipe (3) and the pull bar (7), guarantee takes urine and the homogeneity of person under inspection.
- 9. the method for the urine liquid sampler of the disposable pretreatment self-distroyable disposable of preparation according to claim 7, it is characterised in that： The pull bar (7) is fixedly connected with sillicon rubber blocking (5) gluing, the pull bar (7) is made up of the material for being easy to fracture, the drawing Bar (7) is made up of the material beneficial to coding.
- 10. the method for the urine liquid sampler of the disposable pretreatment self-distroyable disposable of preparation according to claim 7, its feature exist In：Described sampling head (2) one end carries dust cap (1), and the sampling head (2) is screw terminal, using fixed component by suction section Part is fixed on the end of sampling pipe (3), and the fixed component is fixing nut (6), and the fixing nut (6) passes through pull bar (7) It is tightened in the rear end of sampling pipe (3).
- 11. the method for the urine liquid sampler of the disposable pretreatment self-distroyable disposable of preparation according to claim 10, its feature exist In：The fixing nut (6) is the fixing nut (6) with flat hole, and the pull bar (7) is the wooden pull bar of flat, the band The fixing nut (6) for having flat hole is tightened in the rear end of sampling pipe (3) through flat wood pull bar (7).
- 12. the method for the urine liquid sampler of the disposable pretreatment self-distroyable disposable of preparation according to claim 7, its feature exist In：The pumping part is easy to the coding that fractures and be easy to.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510176247.3A CN104777012B (en) | 2015-04-15 | 2015-04-15 | A kind of disposable pretreatment self-distroyable disposable urine liquid sampler and preparation method thereof |
| PCT/CN2016/078849 WO2016165587A1 (en) | 2015-04-15 | 2016-04-08 | Disposable, pre-treated and auto-destructing urine sampler and production method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510176247.3A CN104777012B (en) | 2015-04-15 | 2015-04-15 | A kind of disposable pretreatment self-distroyable disposable urine liquid sampler and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104777012A CN104777012A (en) | 2015-07-15 |
| CN104777012B true CN104777012B (en) | 2017-11-24 |
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| CN201510176247.3A Active CN104777012B (en) | 2015-04-15 | 2015-04-15 | A kind of disposable pretreatment self-distroyable disposable urine liquid sampler and preparation method thereof |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN104777012B (en) |
| WO (1) | WO2016165587A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104777012B (en) * | 2015-04-15 | 2017-11-24 | 戚本昊 | A kind of disposable pretreatment self-distroyable disposable urine liquid sampler and preparation method thereof |
| CN109628286B (en) * | 2019-01-15 | 2022-01-07 | 泰普生物科学（中国）有限公司 | Transportation culture apparatus |
| CN111964976A (en) * | 2020-08-06 | 2020-11-20 | 沈阳农业大学 | Preparation method of male animal urine collecting device |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE1005090A5 (en) * | 1991-06-25 | 1993-04-13 | Saliva Diagnostic Systems Inc | Device and sampling system fitness sample. |
| US5393494A (en) * | 1992-05-28 | 1995-02-28 | Diasys Corporation | Apparatus for drawing fluid sample, components thereof, and slide assembly for use therewith |
| CN100359314C (en) * | 2004-02-17 | 2008-01-02 | 陈格 | Method and device for drying and preserving liquid sample |
| CN1994224A (en) * | 2006-01-06 | 2007-07-11 | 张洪杰 | A suction type hemostix |
| CN101534719A (en) * | 2006-09-06 | 2009-09-16 | 彼得·A·K·勇 | Retractable sectional type bio-molecule collector swab system |
| US7850922B2 (en) * | 2008-02-13 | 2010-12-14 | Capitol Vial Inc. | Fluid sample collection system |
| CN104777012B (en) * | 2015-04-15 | 2017-11-24 | 戚本昊 | A kind of disposable pretreatment self-distroyable disposable urine liquid sampler and preparation method thereof |
-
2015
- 2015-04-15 CN CN201510176247.3A patent/CN104777012B/en active Active
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2016
- 2016-04-08 WO PCT/CN2016/078849 patent/WO2016165587A1/en active Application Filing
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| Publication number | Publication date |
|---|---|
| WO2016165587A1 (en) | 2016-10-20 |
| CN104777012A (en) | 2015-07-15 |
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