CN104689195A - Traditional Chinese medicine preparation for preventing ventricular remodeling of myocardial infarction - Google Patents
Traditional Chinese medicine preparation for preventing ventricular remodeling of myocardial infarction Download PDFInfo
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- CN104689195A CN104689195A CN201510094282.0A CN201510094282A CN104689195A CN 104689195 A CN104689195 A CN 104689195A CN 201510094282 A CN201510094282 A CN 201510094282A CN 104689195 A CN104689195 A CN 104689195A
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Abstract
The invention discloses a traditional Chinese medicine preparation for preventing ventricular remodeling of myocardial infarction. The traditional Chinese medicine preparations, namely longan pulp, downy aletris, king pedicularis root, lousewort root, asiatic bilberry root, dockleaved knotweed herb root, scarlet kadsura root, root of Yunnan camptandra, hibiscus root and smallflower milkwort herb with root are selected to be decocted into a decoction. The traditional Chinese medicine preparation is capable of preventing ventricular remodeling of myocardial infarction, strengthening the middle warmer, dredging collaterals, combining dredging with tonifying, tonifying qi to nourish blood, tonifying qi to generate vigorous commander of blood, smoothening blood supply and dispersing blood stasis to complement each other, so that a relatively good clinical effect is obtained.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine preparation preventing ventricular remodeling after myocardial infarction.
Background technology
Ventricular remodeling after myocardial infarction mainly refers to myocardium of ventricle because the extensive ischemia anoxia-induced apoptosis of myocardial cell and the myocardial muscle load increase that remains cause myocardial cell to occur the pathological change process of size, shape and organizational structure and myocardial function after myocardial infarction, and atrial natriuretic peptide and TNF-α etc. have material impact in the forming process of remodeling ventricle.Wherein atrial natriuretic sodium is mainly directly by suppressing the Sodium ransport in renal proximal tubules and marrow in collecting tubule and suppression adrenaline secretion and activity thereof thus reducing load before and after heart, improve myocardial cell oxygen to supply, reduce oxygen consumption, slow down the plumpness of myocardial cell, especially in the centrifugum process of generation, reduce cardiac dilatation, retain patient's heart and remain myocardial function aspect, the myocardial ischemia of research prompting in the past causes the physics of myocardial necrosis and cardiac muscle, chemistry, biological damage all will cause ventricular muscle cell to synthesize, the exception of secretion and release atrial natriuretic peptide, when general pathologic condition is as plump in ventricular muscles and cardiac function declines, in body, atrial natriuretic peptide secretion significantly declines, the apoptosis of normal myocardial cells can be caused after TNF-α acts on myocardial cell in addition, thus cause the minimizing of number of myocardial cells, but also will the increase of heart intramuscular collagen content be caused, cause the generation of remodeling ventricle.Because western medical treatment effect was not satisfactory in the past, clinical trial proves, Chinese medicine preparation of the present invention, treating myocardial infarction and preventing remodeling ventricle, can improve patient's infarct size, improves left chamber function, achieves good effect, be worthy to be popularized.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine preparation preventing ventricular remodeling after myocardial infarction.In the present invention, patient uses Chinese medicine preparation to intervene remodeling ventricle, and invigorating middle warmer residence is logical, through-supplementation, and the prosperous then blood of gas is raw, and gas foot then handsome blood is strong, and blood fortune is unimpeded, and blood stasis is from loose, and both bring out the best in each other.
The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this prevention ventricular remodeling after myocardial infarction is made up of the Chinese medicine of following weight portion: Arillus Longan 6-15 part, Herba Aletridis Khasianae 15-30 part, Pedicularis rex C. B. Clarke ex Maxim. 15-30 part, Radix Pedicularis Henryi 15-30 part, Radix Vaccinii Bracteati 9-15 part, Herba Polygoni nodosi 9-15 part, Radix Kadsurae Coccineae 5-10 part, Stahlianthus hainanensis (Hayata) T. L. Wu 1-3 part, Radix abelmoschi manihot 3-9 part, Herba Polygalae Telephioidis 10-20 part.
Preferably, Arillus Longan 10 parts, Herba Aletridis Khasianae 22 parts, Pedicularis rex C. B. Clarke ex Maxim. 23 parts, Radix Pedicularis Henryi 22 parts, Radix Vaccinii Bracteati 12 parts, Herba Polygoni nodosi 13 parts, Radix Kadsurae Coccineae 7 parts, Stahlianthus hainanensis (Hayata) T. L. Wu 2 parts, Radix abelmoschi manihot 6 parts, Herba Polygalae Telephioidis 15 parts.
Above-mentioned Chinese medicine decocting is made decoction by preparation method.
Fang Zhong: Arillus Longan fills blood, heart-spleen boosting, calm the nerves; Herba Aletridis Khasianae fills blood, stop blooding; Pedicularis rex C. B. Clarke ex Maxim. benefiting vital QI and blood, invigorating spleen to remove dampness; Radix Pedicularis Henryi fills blood, active; Radix Vaccinii Bracteati dissipating blood stasis, detumescence, pain relieving; Herba Polygoni nodosi promoting blood circulation to remove blood stasis, detumescence; Radix Kadsurae Coccineae promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis; Stahlianthus hainanensis (Hayata) T. L. Wu promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain; Radix abelmoschi manihot inducing diuresis to remove edema, dissipating blood stasis detoxify; Herba Polygalae Telephioidis promoting blood circulation to remove blood stasis, pain relieving.
Clinical data
1. patients of acute myocardial infarction 100 example that in January, 2012 to 2014, my institute of year December accepted for medical treatment is divided into 2 groups by physical data at random, man 26 example in observation group, female 24 example; 56 ~ 84 years old age, man 25 example in matched group, female 25 example; 55 ~ 84 years old age, the comparing difference not statistically significants (P > 0.05) such as 2 groups of Genders, age, disease times and merging diseases.
2. diagnostic criteria recognizes unstable angina pectoris and non-ST segment elevation myocardial infarction treatment guidelines (2002) and acute myocardial infarction guide (2002) with reference to ACC/AI.
Exclusion standard is associated with liver, kidney and the severe complication such as hormonal system, hemopoietic system; Psychological problem auditory dysesthesia, being in a bad way can not the person of cooperation; Companion's severe arrhythmia, as atrial fibrillation, Frequent atrial premature beats secondary, frequent premature ventricular beats etc.; Permanent pacemaker person is installed; Suffers from the disease of obvious sympathetic activation or suppression, as hyperthyroidism, hypothyroidism, pheochromocytoma, heating etc.
3. after Therapeutic Method patient admits, all implement monitoring, bed oxygen uptake, intravenous morphine injection in a small amount, suitable sedation and analgesia process, according to patient's discrepancy amount, adjustment blood volume occurs to prevent heart failure, prevention and therapy arrhythmia, implement the reperfusion as treatment such as thrombolytic or intervention when having ready conditions, adopt anticoagulant, Anti-platelet therapy, according to circumstances can select beta-blocker.On the basis of conventional therapy, matched group adopts captopril (Changzhou Pharmaceutical Factory Co., Ltd, traditional Chinese medicines accurate word H32021671) oral, and initial dose 25mg, 3 times/d, serve on 4 weeks; Observation group adopts the Chinese medicine preparation of invention, medicine forms: Arillus Longan 10g, Herba Aletridis Khasianae 22g, Pedicularis rex C. B. Clarke ex Maxim. 23g, Radix Pedicularis Henryi 22g, Radix Vaccinii Bracteati 12g, Herba Polygoni nodosi 13g, Radix Kadsurae Coccineae 7g, Stahlianthus hainanensis (Hayata) T. L. Wu 2g, Radix abelmoschi manihot 6g, Herba Polygalae Telephioidis 15g, boiled water decocts, 1 dose/d, sooner or later 1 time is respectively taken, continuous treatment 2 weeks is a course for the treatment of, treats two courses for the treatment of altogether.
4. therapeutic outcome treatment after observation group patient atrial natriuretic peptide and TNF-α all remarkable in matched group (P < 0.05).
After 2 groups of treatments, atrial natriuretic peptide and TNF-α compare ng/L
| Group | Atrial natriuretic peptide | TNF-α |
| Observation group | 155.6±18.2 | 85.6±10.3 |
| Matched group | 356.9±28.9 | 258.6±23.1 |
In therapeutic process matched group patient have 7 examples to occur fainting, headache, dizzy, paraesthesia, insomnia and the symptom such as tired, there is the symptom such as dysgeusia, nausea,vomiting,diarrhea in 6 examples, stomachache, constipation, xerostomia inappetence appear in 2 examples, oral cavity has into taste or gold bits taste steps on symptom.Treatment group has 3 examples to occur gastrointestinal side effect, and untoward reaction rate is lower.
Detailed description of the invention
Embodiment one: take Arillus Longan 10g, Herba Aletridis Khasianae 22g, Pedicularis rex C. B. Clarke ex Maxim. 23g, Radix Pedicularis Henryi 22g, Radix Vaccinii Bracteati 12g, Herba Polygoni nodosi 13g, Radix Kadsurae Coccineae 7g, Stahlianthus hainanensis (Hayata) T. L. Wu 2g, Radix abelmoschi manihot 6g, Herba Polygalae Telephioidis 15g, makes decoction by above-mentioned Chinese medicine decocting.
Embodiment two: take Arillus Longan 15g, Herba Aletridis Khasianae 30g, Pedicularis rex C. B. Clarke ex Maxim. 30g, Radix Pedicularis Henryi 30g, Radix Vaccinii Bracteati 15g, Herba Polygoni nodosi 15g, Radix Kadsurae Coccineae 10g, Stahlianthus hainanensis (Hayata) T. L. Wu 3g, Radix abelmoschi manihot 9g, Herba Polygalae Telephioidis 20g, makes decoction by above-mentioned Chinese medicine decocting.
Embodiment three: take Arillus Longan 6g, Herba Aletridis Khasianae 15g, Pedicularis rex C. B. Clarke ex Maxim. 15g, Radix Pedicularis Henryi 15g, Radix Vaccinii Bracteati 9g, Herba Polygoni nodosi 9g, Radix Kadsurae Coccineae 5g, Stahlianthus hainanensis (Hayata) T. L. Wu 3g, Radix abelmoschi manihot 3g, Herba Polygalae Telephioidis 10g, makes decoction by above-mentioned Chinese medicine decocting.
Claims (2)
1. prevent a Chinese medicine preparation for ventricular remodeling after myocardial infarction, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Arillus Longan 6-15 part, Herba Aletridis Khasianae 15-30 part, Pedicularis rex C. B. Clarke ex Maxim. 15-30 part, Radix Pedicularis Henryi 15-30 part, Radix Vaccinii Bracteati 9-15 part, Herba Polygoni nodosi 9-15 part, Radix Kadsurae Coccineae 5-10 part, Stahlianthus hainanensis (Hayata) T. L. Wu 1-3 part, Radix abelmoschi manihot 3-9 part, Herba Polygalae Telephioidis 10-20 part.
2. a kind of Chinese medicine preparation preventing ventricular remodeling after myocardial infarction as claimed in claim 1, is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Arillus Longan 10 parts, Herba Aletridis Khasianae 22 parts, Pedicularis rex C. B. Clarke ex Maxim. 23 parts, Radix Pedicularis Henryi 22 parts, Radix Vaccinii Bracteati 12 parts, Herba Polygoni nodosi 13 parts, Radix Kadsurae Coccineae 7 parts, Stahlianthus hainanensis (Hayata) T. L. Wu 2 parts, Radix abelmoschi manihot 6 parts, Herba Polygalae Telephioidis 15 parts.
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| CN201510094282.0A CN104689195A (en) | 2015-02-26 | 2015-02-26 | Traditional Chinese medicine preparation for preventing ventricular remodeling of myocardial infarction |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090081860A (en) * | 2008-01-25 | 2009-07-29 | 주식회사 유니베라 | Pharmaceutical composition comprising processed Aloe vera gel for preventing or treating type II diabetes |
| CN102861231A (en) * | 2011-07-08 | 2013-01-09 | 河北以岭医药研究院有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for treating ventricular remodeling after myocardial infarction |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090081860A (en) * | 2008-01-25 | 2009-07-29 | 주식회사 유니베라 | Pharmaceutical composition comprising processed Aloe vera gel for preventing or treating type II diabetes |
| CN102861231A (en) * | 2011-07-08 | 2013-01-09 | 河北以岭医药研究院有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for treating ventricular remodeling after myocardial infarction |
Non-Patent Citations (1)
| Title |
|---|
| 陈可冀: "《心血管病与活血化瘀：中国中医科学西苑医院心血管病中心中西医结合50年论文选集》", 31 August 2009, 北京科学技术出版社 * |
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