CN104622897A - Skin moisturizer for treating skin disease and preparation method of skin moisturizer - Google Patents
Skin moisturizer for treating skin disease and preparation method of skin moisturizer Download PDFInfo
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Abstract
The invention provides a skin moisturizer for treating a skin disease and a preparation method of the skin moisturizer. The skin moisturizer is mainly prepared from the following raw materials in parts by weight: 10-20 parts of alginate oligosaccharide, 0.5-5 parts of a solubilizer, 0.5-1 part of sodium chloride, 5-10 parts of a dispersing agent, 5-20 parts of a tackifier, 2-3 parts of a preservative and 2-3 parts of an antioxidant, wherein the solvent is injection water; and the preparation method comprises the following steps: dissolving 0.2-0.3 part of sodium chloride into residual injection water; adding the solubilizer, the tackifier, the preservative, the dispersing agent and the antioxidant, stirring evenly, and adjusting the pH value to be 3.5-6.5; dissolving the alginate oligosaccharide into the residual injection water, adding residual sodium chloride, stirring and mixing with the substances obtained from the steps; and packing and sterilizing to obtain the skin moisturizer. The skin moisturizer provided by the embodiment has the effects of good treatment effect, mild medicine property and no side effect.
Description
Technical field
The present invention relates to field of medicaments, treat dermopathic skin care liquid and preparation method thereof in particular to one.
Background technology
Skin is the outermost protective tissue of human body, is also the maximum organ of human body, mainly carries protection health, perspire, feels cold and hot and the function of pressure.Skin covers whole body, and it to make in body various tissue and organ from the invasion and attack of physical property, mechanicalness, chemical and pathogenic microorganism.Dermatosis is one of the commonly encountered diseases, frequently-occurring disease that have a strong impact on health, because of after skin is subject to the impact of the internal and external factors such as fungal infection, wound, allergy, poisoning, viral infection, its form, structure, function all change, produce the disease of pathological process, and the various clinical manifestation of corresponding generation.The multiplex antibacterial-anti-inflammatory drug of Current treatments dermatosis, have aerosol (YUNNAN BAIYAO), unguentum (dexamethasone acetate) etc., these medicines are used widely as nonprescription drugs.But these drug treatment regimen are narrower, it is better that such as YUNNAN BAIYAO is used for traumatism treatment effect, and it is mainly containing medical material that is antibacterial and blood circulation promoting and blood stasis dispelling, and can promote topical blood flow, have additional nutrients provisioning, promotes wound healing.And common skin medication dexamethasone acetate has antiinflammatory, antiallergic, Antishock function.But as adrenocortical hormone medicine, itself have multiple side effect, as immunosuppressant, resistance declines, easy infection; Tissue metabolism is vigorous, and wound is not easy to grow; Abnormal carbohydrate metabolism, occurs or diabetes is increased the weight of; Adrenal cortex function suppresses; Peptic ulcer; Seborrheic dermatitis etc.
And due to a large amount of uses of antibiotics, make environment be polluted, bacterial gene suddenlys change and produces drug resistance, and resistant rate improves gradually, and nearly all antibacterial all obtains drug resistant gene, and this problem is on the rise.Tackle bacterial drug resistance except reasonable utilization antibiotic, main countermeasure is developed the effective new drug of Resistant strain and novel formulation exactly, and therefore how inventing the preparation that a kind of effective treatment dermatosis can not produce again any side effect is technical problem nowadays urgently to be resolved hurrily.
In view of this, special proposition the present invention.
Summary of the invention
The first object of the present invention is to provide one to treat dermopathic skin care liquid, and described skin care liquid has that therapeutic effect is good, the property of medicine is gentle and the advantage such as without any side effects.
The second object of the present invention is to provide a kind of preparation method of the described dermopathic skin care liquid for the treatment of, the method have operational approach simple, can the advantage such as active ingredient of each component in complete reservation skin care liquid.
In order to realize above-mentioned purpose of the present invention, spy by the following technical solutions:
Embodiments provide one and treat dermopathic skin care liquid, make primarily of following raw material: in mass fraction, brown alga oligose 10-20 part, solubilizing agent 0.5-5 part, sodium chloride 0.5-1 part, dispersant 5-10 part, setting agent 5-20 part, antiseptic 2-3 part, antioxidant 2-3 part; Solvent is water for injection.
The skin care liquid that the embodiment of the present invention provides, can effectively treat various dermatosis, as solar dermatitis, eczema, allergic dermatitis and psoriasis etc., and it is without any side effects, for there being the various antibacterials of drug resistance also can thoroughly kill, all there is inhibitory action to staphylococcus aureus, penicillium, Aspergillus niger etc.Using method is also very simple, and according to the state of an illness, this skin care liquid can be made spray form and carry out spraying treatment every several hours to dermatosis position every day, take a turn for the better to patient's diseased region, rear minimizing times for spraying, until healing.
In the present invention, brown alga oligose has good activation and facilitation to nonspecific immunity or specific immune system, energy activating macrophage, after activation, there is cytotoxicity, the brown alga oligose of blood sugar lowering blood fat suitable dose can prevent the formation of hypercholesterolemia preferably, has blood fat reducing, safeguards the effect of cardiovascular normal function.Free radical resisting oxidation Algin polysaccharide not only has the effect of Scavenger of ROS, significantly can also reduce the content of lipid peroxide, improve the activity of peroxidase and superoxide dismutase, have the effect of removing polyradical and anti peroxidation of lipid.Brown alga oligose also has anti-inflammatory, is the oligosaccharide extracted in Sargassum, abundance, is the good succedaneum of sLex, sLea and Heparin Oligosaccharides in theory, has good potential medical value.Immunoregulatory activity.Preferably, brown alga oligose 12-15 part, preferred, brown alga oligose 17-19 part, can also select 11 parts, 13 parts, 18 parts etc.
Brown alga oligose has following characteristic: be khaki powder, can be water-soluble, and stability is strong.There is multinomial biological function, medicine, food, daily use chemicals, feedstuff and agriculture in be widely used.Algin is by 1,4-beta-D-mannuronic acid (MA) and 1,, there are three kinds of blocks in its molecule in the block lienar for polymer of 4-α-L-guluronic acid (GA) two kinds of monomer compositions: the block (PMG) that equal polymannuronate (PM), all guluronic acid (PG), two kinds of monomer M A and GA replace.The structure of the algin oligosaccharide adopting different biodegrading process to obtain is different, and different structures can embody from mass spectrum and nuclear magnetic resonance map.Degraded further by Brown algae cell wall polysaccharides the functional oligose obtained, the degree of polymerization is between 2-20.
In the present invention, sodium chloride has adjustment extracellular osmotic pressure, to the situation of sodium of losing blood, lose, there is good therapeutical effect, auxiliary treatment dermatosis can be played, reach the object fully recovered fast in disease place, preferably, its consumption is between 0.5-0.8 part, be more preferably between 0.9-1 part, 0.6 part, 0.7 part and 0.9 part etc. can also be selected.
The present invention is for making in the various auxiliary materials in skin care liquid, one or more in ethylene glycol, propylene glycol and glycerol are generally selected in solubilizing agent, preferred glycerol, the dissolubility between each raw material can be strengthened, make syncretizing effect better, preferably, its consumption is 1-3 part, preferred consumption is 2-4 part, can also select 2.5 parts, 3.5 parts etc.
Dispersant has the surface nature of modified feedstock particle, the mobility of adjustment particle and make each raw material can be dispersed, increase the effect of the mixed stability of raw material, therefore consider from its effect and economy two aspect, its suitable addition is preferably 7-9 part, being more preferably 8-10 part, kind can be one or more in sodium carboxymethyl cellulose, ethyl cellulose and carboxymethylcellulose calcium, preferably carboxymethyl cellulose sodium.
Antiseptic has and can stop growth of microorganism, extend the service life of product, to guarantee the safety of product, prevent from patient being treated to the effect causing unnecessary infection, its suitable addition is 2-2.5 part, 2.1 parts, 2.2 parts, 2.3 parts etc. can also be selected, kind can be selected one or more in benzyl alcohol, benzalkonium chloride, p-hydroxy Benzoic Acid ester, n-butyl alcohol, benzoic acid, citric acid, sorbic acid, sodium benzoate and sodium propionate, preferred sodium benzoate.
Antioxidant has the oxidation resistance that can strengthen obtained medicament, prevent it from ruining, eliminate the free radical just produced, or impel the decomposition of hydroperoxides, stop effect that chain reaction is carried out, therefore consider from its effect and economy two aspect, its addition is preferably 2-2.5 part, 2.1 parts can also be selected, 2.2 part, 2.3 parts etc., kind can select vitamin E, carotenoid, ascorbic acid, ascorbyl palmitate, arabo-ascorbic acid, sodium erythorbate, citric acid, one or more in sodium sulfite EDTA and phosphoric acid derivatives, preferred sodium sulfite.Described setting agent is the mixture of sodium alginate or calcium alginate or above-mentioned two kinds, preferred sodium alginate.
The embodiment of the present invention additionally provides a kind of preparation method for the treatment of dermopathic skin care liquid, comprises the steps:
(A) sodium chloride 0.2-0.3 part is dissolved in partial syringe water, then solubilizing agent, setting agent, antiseptic, dispersant and antioxidant is added and stir, pH value is adjusted between 3.5-6.5, for subsequent use;
(B) brown alga oligose is dissolved in remaining water for injection, adds the sodium chloride of surplus, after stirring, after the material obtained with above-mentioned (A) step mixes, after packaging, sterilization steps, to obtain final product.
The preparation method of the skin care liquid that the embodiment of the present invention provides, preparation method is simple to operate, flexible, wherein in the process adding each raw material, need stir and add lower a kind of raw material again, homogeneous state is formed can fully merge, pH value preferably controls between 3.5-6.5 in addition, acid excessive or alkaline excessive being unfavorable for preserves, therapeutic effect is not good yet, if peracid can select sodium hydroxide to regulate, hydrochloric acid can be selected to regulate if cross alkali, grasp flexibly according to concrete practical situation.
In addition, when mixing, to be more noticeablely, to merge after first will mixing respectively during mixing again, not easily mix homogeneously when preventing brown alga oligose from mixing as major ingredient, affects the follow-up drug effect making product.
Further, in described step (A), preferably filter after having regulated PH, to filter impurity wherein, can take to add the mode using membrane filtration after injection-use activated carbon stirs, namely first refilter with after the abundant absorption impurity of injection-use activated carbon, such filter effect is better.
Finally, in order to the object making product reach abundant sterilizing, preferably adopt the mode of moist heat sterilization to carry out sterilizing, if think to promote further sterilization effect skin care liquid can be closed completely that to carry out moist heat sterilization better, temperature is typically chosen in 121 DEG C.
The skin care liquid of the embodiment of the present invention can treat following several dermatosis:
1, solar dermatitis
Solar dermatitis is due to skin UVA type ultraviolet direct projection skin in extraneous factor sunlight, longer by its wavelength, penetration power is strong, can transdermal top layer, go deep into corium with undertissue, intradermal various kinds of cell is made to discharge histamine, the inflammatory mediator such as serotonin, kassinin kinin, make intradermal vasodilation, permeability increases, and destroys the fine structure of the skin inside such as collagen protein, elastic fibrous tissue, makes it produce pathologic change, be inflamed reaction, and main manifestations is erythema, edema, vesicle and pigmentation, desquamation.
2, eczema
Eczema is affected by internal and external factor, such as: the imbalance of human body emotional lability, organism endocrine, organism infection, climatic effect, staphylococcus aureus, penicillium, Aspergillus niger infection etc., being affected by internal body factor makes body metabolism disorderly, the toxin produced in body does not excrete in time, enter skin histology by blood capillary, cause skin histology allergy, or due to external factor impact, pathogenic bacteria invasion skin surface, makes skin surface generation pathological changes.Often show as pimple, phlysis, mound bleb, pustule, folliculitis, fester.
3, allergic dermatitis
Allergic dermatitis is the dermatosis that causes because of anaphylactogen of responsive body constitution person mainly, mainly refer to that human contact arrives some anaphylactogen, as: the material that zest is stronger, various animal skin, plant pollen etc., allergenic substance enters human body by skin, mouth, nose etc., stimulate human capillary vessel, make telangiectasis, and stimulate the inflammatory mediators such as dermal tissue cell, histamine release of mast cell, leukotriene, thus cause dermatosis.Main manifestations for red and swollen, itch, welt, decortication, pimple, water scar (or large scar), rotten to the corn, the skin disorder such as to ooze out.
4, psoriasis
Psoriasis is also known as psoriasis.Motherland's medical science claims psoriasis to be “ Bai Mange ", be common chronic, recurrent, struvite dermatosis.Up to now not yet clearly psoriasic real pathogenesis, but research find its pathogeny with hereditary, immunity of organism mediates, courses of infection, medicine, life etc. are relevant, pathological manifestations feature is the pimple occurring differing in size, erythema, surface coverage silvery white squama, clear border, is apt to occur in scalp, extremity stretches side and back.Winter in spring easily recurs or increases the weight of, and many alleviations summer and autumn.
The skin care liquid of the embodiment of the present invention, for the treatment aspect of solar dermatitis, can directly infiltrate skin inside, suppress intradermal vasodilation, reduce osmotic pressure, suppress pathogenic bacteria invasion, and by suppressing Skin Cell to the release of the inflammatory mediator such as histamine, 5-hydroxy tryptamine, repair the Cutaneous damage because this dermatitis causes, reduce the formation of cicatrix of skin.The present invention is directed to the treatment of eczema, effectively can suppress the growth and breeding of the pathogenic bacteria such as staphylococcus, penicillium, effectively suppress the skin allergic reaction that internal and external reasons causes, to the pimple in skin affected part, the treatment of herpes, phlysis, squama etc.By infiltrating skin inner layer, suppressing the generation of virulence factor, promoting the growth of Skin Cell, strengthen the immunity of skin histology, accelerate the reparation of skin histology.The present invention is directed to the treatment of allergic dermatitis, can be used for treating caused by allergy red swelling of the skin, itch, pain, the disease such as decortication, by suppressing the Skin Cell allergy because allergy causes, inflammatory mediator such as T suppression cell release histamine, leukotriene etc., to coordinate orally taken for curing medicine as antihistaminic (diphenhydramine, loratadine etc.), gluconic acid calcium preparation etc., the injury repairing of skin histology can be accelerated, suppress the generation of anaphylaxis pathological changes.The present invention is directed to psoriasis treatment, can be used for treatment because of extraneous factor, the skin rashes that live bad, courses of infection, medicine etc. cause, erythema, the diseases such as silvery white squama, accelerate the injury repairing of skin histology.
Compared with prior art, beneficial effect of the present invention is:
(1) skin care liquid of the embodiment of the present invention can well treat various types of dermatosis, have that antibacterial infection, free radical resisting oxidation, antiviral, moisturizing are sun-proof, the characteristic of Promote cell's growth, the property of medicine is gentle, and has no side effect, and can not recur once cure again;
(2) skin care liquid that the embodiment of the present invention provides can well suppress various and have drug-fast antibacterial, as staphylococcus aureus, penicillium, Aspergillus niger etc., and can accelerate histiocytic growth, reduces the release of inflammatory mediator;
(3) preparation method of the embodiment of the present invention simple to operate, can the active ingredient of each component in complete reservation skin care liquid, fully retain its drug effect, and fully merge to make its comprehensive therapeutic effect strengthen further by the mutual compatibility of the property of medicine of each component.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but it will be understood to those of skill in the art that the following example only for illustration of the present invention, and should not be considered as limiting the scope of the invention.Unreceipted actual conditions person in embodiment, the condition of conveniently conditioned disjunction manufacturer suggestion is carried out.Agents useful for same or the unreceipted production firm person of instrument, be and can buy by commercially available the conventional products obtained.
Embodiment 1
Raw material and the solvent load of skin care liquid are as follows:
Preparation method:
Measure 900ml water for injection, add 0.2g sodium chloride and be stirred to and dissolve completely, after continuing after adding glycerol, sodium alginate, benzyl alcohol, sodium carboxymethyl cellulose, ascorbic acid successively to stir, regulate the PH of solution to 3.5; Brown alga oligose is dissolved in a small amount of water for injection, and stir evenly after adding 0.3g sodium chloride and merge with above-mentioned solution, benefit injects water to 1000ml, each spray bottle subpackage 50ml medicinal liquid, moist heat sterilization 15min, rejects substandard product, dries, after meeting national standard for quality testing is every, can sell by finished product.
Embodiment 2
Raw material and the solvent load of skin care liquid are as follows:
Preparation method:
Measure 900ml water for injection, add 0.3g sodium chloride to be stirred to and to dissolve completely, after continuing after adding the mixture of the mixture of glycerol and propylene glycol, sodium alginate and calcium alginate, sodium formate, ethyl cellulose, vitamin E successively to stir, with the PH of hydrochloric acid or sodium hydrate regulator solution to 6.5, after leaking in advance with funnel, use microporous filter membrane fine straining again, after checking the transparency of filtrate, for subsequent use; Brown alga oligose is dissolved in a small amount of water for injection, and stir evenly after adding 0.5g sodium chloride and merge with above-mentioned solution, benefit injects water to 1000ml, each spray bottle subpackage 50ml medicinal liquid, and sealing and with filling with envelope, moist heat sterilization 15min, reject substandard product, dry, after meeting national standard for quality testing is every, can sell by finished product.
Embodiment 3
Raw material and the solvent load of skin care liquid are as follows:
Preparation method:
Measure 900ml water for injection, add 0.2g sodium chloride to be stirred to and to dissolve completely, after continuing after adding ethylene glycol, calcium alginate, citric acid, carboxymethylcellulose calcium, arabo-ascorbic acid successively to stir, with the PH of hydrochloric acid or sodium hydrate regulator solution to 4.5, after leaking in advance with funnel, add the microporous filter membrane fine straining using 0.5mm after injection-use activated carbon stirs 20min again, after checking the transparency of filtrate, for subsequent use; Brown alga oligose is dissolved in a small amount of water for injection, and stir evenly after adding 0.7g sodium chloride and merge with above-mentioned solution, benefit injects water to 1000ml, each spray bottle subpackage 50ml medicinal liquid, and sealing and with filling with envelope, moist heat sterilization 15min, reject substandard product, dry, after meeting national standard for quality testing is every, can sell by finished product.
Embodiment 4
Raw material and the solvent load of skin care liquid are as follows:
Preparation method:
Measure 900ml water for injection, add 0.3g sodium chloride to be stirred to and to dissolve completely, after continuing after adding ethylene glycol, sodium alginate, citric acid, sodium carboxymethyl cellulose, arabo-ascorbic acid successively to stir, with the PH of hydrochloric acid or sodium hydrate regulator solution to 3.5, after leaking in advance with funnel, add the microporous filter membrane fine straining using 0.65mm after injection-use activated carbon stirs 20min again, after checking the transparency of filtrate, for subsequent use; Brown alga oligose is dissolved in a small amount of water for injection, and stir evenly after adding 0.7g sodium chloride and merge with above-mentioned solution, benefit injects water to 1000ml, each spray bottle subpackage 50ml medicinal liquid, and sealing and with filling with envelope, moist heat sterilization 15min, reject substandard product, dry, after meeting national standard for quality testing is every, can sell by finished product.
Embodiment 5
Raw material and the solvent load of skin care liquid are as follows:
Preparation method:
Measure 900ml water for injection, add 0.3g sodium chloride to be stirred to and to dissolve completely, after continuing after adding ethylene glycol, sodium alginate, citric acid, sodium carboxymethyl cellulose, arabo-ascorbic acid successively to stir, with the PH of hydrochloric acid or sodium hydrate regulator solution to 3.5, after leaking in advance with funnel, add the microporous filter membrane fine straining using 0.65mm after injection-use activated carbon stirs 20min again, after checking the transparency of filtrate, for subsequent use; Brown alga oligose is dissolved in a small amount of water for injection, and stir evenly after adding 0.2g sodium chloride and merge with above-mentioned solution, benefit injects water to 1000ml, each spray bottle subpackage 50ml medicinal liquid, and sealing and with filling with envelope, moist heat sterilization 15min, reject substandard product, dry, after meeting national standard for quality testing is every, can sell by finished product.
Embodiment 6
Raw material and the solvent load of skin care liquid are as follows:
Preparation method:
Measure 900ml water for injection, add 0.3g sodium chloride to be stirred to and to dissolve completely, after continuing after adding ethylene glycol, sodium alginate, citric acid, sodium carboxymethyl cellulose, arabo-ascorbic acid successively to stir, with the PH of hydrochloric acid or sodium hydrate regulator solution to 3.5, after leaking in advance with funnel, add the microporous filter membrane fine straining using 0.65mm after injection-use activated carbon stirs 20min again, after checking the transparency of filtrate, for subsequent use; Brown alga oligose is dissolved in a small amount of water for injection, and stir evenly after adding 0.7g sodium chloride and merge with above-mentioned solution, benefit injects water to 1000ml, each spray bottle subpackage 50ml medicinal liquid, and sealing and with filling with envelope, moist heat sterilization 15min, reject substandard product, dry, after meeting national standard for quality testing is every, can sell by finished product.
Experimental example 1
Select 30 people, be solar dermatitis patient, wherein clinical manifestation is comparatively mild skin patient 13 example such as erythema, edema, man 5 example, female 8 example, the age is 3 ~ 45 years old, is divided into 2 groups at random, often organize 15 people, matched group selects YUNNAN BAIYAO to spray, and test group selects the skin care liquid of the embodiment of the present invention 1; Clinical manifestation be vesicle, erosion, desquamation etc. comparatively serious skin patient 17 example, man 4 example, female 13 example, the age is 23 ~ 42 years old, above disease time be the summer has set in time be exposed to the sun after cause.
Therapeutic Method: adopt spray to carry out spraying treatment every 6 hours to dermatosis position every day, for three days on end, observe matched group and test group state of an illness recovery situation.
Result of the test: the result of test group: patients with mild is recovered normally substantially, and the symptom such as erythema, edema disappears substantially, and skin surface cicatrix disappears substantially, has a little skin lesion cicatrix only and does not also disappear; Middle severe patients symptomatic obviously alleviates, and the rotten to the corn scope in skin lesion surface reduces, and vesicle reduces, without desquamation symptom.After severe patient continues 4 days resuming treatment again, the state of an illness is eliminated substantially, and affected skin is without symptoms such as erosion, vesicles, and cicatrix is not left on skin lesion surface.
The result of matched group: the symptoms such as patients with mild erythema, edema disappear substantially, but due to side effect, skin is micro-red, and severe case need again after 10 days resume treatment, and ability and sagacity take a favorable turn.
Experimental example 2
Select 48 people, be skin eczema patient.Wherein because of eczema patients 36 example that the body endogenous causes of ill such as dyspepsia, insomnia, overtired, endocrine disturbance cause, man 11 example, female 25 example, at 29 ~ 47 years old age, not etc., disease does not show as that illing skin thickens more, brownish red or pigmentation for disease time 1 ~ 3 year, rough surface, cover squama, or form a scab because scratching, conscious acute pruritus etc., be divided into 2 groups at random, often organize 22 people, matched group adopts hydrocortisone ointment treatment, and test group adopts the skin care liquid of the embodiment of the present invention 2; Because of eczema patients 12 example that the exopathogenic factors such as living environment change, climate change, cosmetics improper use cause, man 3 example, female 9 example, at 24 ~ 45 years old age, disease time is in half a year, and disease shows as little pimple, papulovesicle or phlysis etc. more.
Therapeutic Method: patient was treated dermatosis position every 4 hours every day, continuous 7 days; Observe matched group and test group state of an illness recovery situation.
Result of the test: the result of test group: patient's recovery effects that endogenous cause of ill causes is better, and above-mentioned each symptom all obviously alleviates, and skin colour obviously recovers normal condition.The dermatosis patient that exopathogenic factor causes, amplitude that sb.'s illness took a favorable turn is comparatively large, and symptom obviously alleviates, and little pimple, papulovesicle, vesicle large area reduce, and after skin recovery, skin lesion cicatrix is obviously less.
The result of matched group: change less, the dermatosis that Yin Neiyin causes, there is slight recovery on its pathological changes skin lesion surface, pachyderma, brownish red or pigmentation, rough surface, covers the symptoms such as squama and alleviates not obvious; The matched group state of an illness is without too large change, and little pimple, papulovesicle or phlysis only have sub-fraction to reduce.
Experimental example 3
Select 38 people, being allergic dermatitis patient, is all the skin hypersensitivity dermatitis owing to causing after the extraneous sensitizer of human contact, wherein man 17 example, female 18 example, at 15 ~ 57 years old age, disease time is after contact allergy material and occurs in 2 days, disease shows as red swelling of the skin more, itches, welt, decortication, pain etc., patient is divided into 2 groups at random, often organize 19 people, matched group loratadine is treated, and test group adopts the skin care liquid of the embodiment of the present invention 3 to treat.
Therapeutic Method: patient was treated dermatosis position every 4 hours every day, observe the curative effect after continuous 2 days.
Result of the test: the result of test group: patient of hypersensitivity's property dermatitis is recovered, red swelling of the skin, itch, welt, decortication, the symptom such as pain eliminate completely, and skin lesion surface scar is repaired completely.
The result of matched group: patient of hypersensitivity's property dermatitis is recovered, but skin lesion surface does not recover normal, there is more cicatrix.
Except above-mentioned several dermatosis, the skin care liquid of the embodiment of the present invention also all has good curative effect to many dermatosiss such as chilblain, insect dermatitis, chloasma.
Although illustrate and describe the present invention with specific embodiment, however it will be appreciated that can to make when not deviating from the spirit and scope of the present invention many other change and amendment.Therefore, this means to comprise all such changes and modifications belonged in the scope of the invention in the following claims.
Claims (10)
1. treat a dermopathic skin care liquid, it is characterized in that, make primarily of following raw material: in mass fraction, brown alga oligose 10-20 part, solubilizing agent 0.5-5 part, sodium chloride 0.5-1 part, dispersant 5-10 part, setting agent 5-20 part, antiseptic 2-3 part, antioxidant 2-3 part; Solvent is water for injection.
2. one according to claim 1 treats dermopathic skin care liquid, it is characterized in that, make primarily of following raw material: in mass fraction, brown alga oligose 12-15 part, solubilizing agent 1-3 part, sodium chloride 0.5-0.8 part, dispersant 7-9 part, setting agent 10-15 part, antiseptic 2-2.5 part, antioxidant 2-2.5 part; Solvent is water for injection.
3. one according to claim 1 treats dermopathic skin care liquid, it is characterized in that, make primarily of following raw material: in mass fraction, brown alga oligose 17-19 part, solubilizing agent 2-4 part, sodium chloride 0.9-1 part, dispersant 8-10 part, setting agent 16-20 part, antiseptic 2-2.5 part, antioxidant 2-2.5 part; Solvent is water for injection.
4. one according to claim 1 treats dermopathic skin care liquid, it is characterized in that, described solubilizing agent is one or more in ethylene glycol, propylene glycol and glycerol, preferred glycerol;
Described dispersant is one or more in sodium carboxymethyl cellulose, ethyl cellulose and carboxymethylcellulose calcium, preferably carboxymethyl cellulose sodium;
Described antioxidant is one or more in vitamin E, carotenoid, ascorbic acid, ascorbyl palmitate, arabo-ascorbic acid, sodium erythorbate, citric acid, sodium sulfite EDTA and phosphoric acid derivatives, preferred sodium sulfite.
5. one according to claim 1 treats dermopathic skin care liquid, it is characterized in that, described setting agent is the mixture of sodium alginate or calcium alginate or above-mentioned two kinds;
Described antiseptic is: in benzyl alcohol, benzalkonium chloride, p-hydroxy Benzoic Acid ester, n-butyl alcohol, benzoic acid, citric acid, sorbic acid, sodium benzoate and sodium propionate one or more, preferred sodium benzoate.
6. a kind of preparation method for the treatment of dermopathic skin care liquid described in any one of claim 1-5, comprises the steps:
(A) sodium chloride 0.2-0.3 part is dissolved in partial syringe water, then solubilizing agent, setting agent, antiseptic, dispersant and antioxidant is added and stir, pH value is adjusted between 3.5-6.5, for subsequent use;
(B) brown alga oligose is dissolved in remaining water for injection, adds the sodium chloride of surplus, after stirring, after the material obtained with above-mentioned (A) step mixes, after packaging, sterilization steps, to obtain final product.
7. a kind of preparation method for the treatment of dermopathic skin care liquid according to claim 6, in described step (A), is adjusted to pH value between 3.5-6.5 with hydrochloric acid or sodium hydroxide.
8. a kind of preparation method for the treatment of dermopathic skin care liquid according to claim 6, in described step (A), after regulating pH value, described method also comprises the step of filtration.
9. a kind of preparation method for the treatment of dermopathic skin care liquid according to claim 8, in described step (A), the step of described filtration is specially: add after injection-use activated carbon stirs and use membrane filtration.
10. a kind of preparation method for the treatment of dermopathic skin care liquid according to claim 6, in described step (B), sterilizing adopts the mode of moist heat sterilization to carry out.
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| CN105796574A (en) * | 2016-05-03 | 2016-07-27 | 宋钦 | Care solution for seborrheic dermatitis |
| CN105963756A (en) * | 2016-06-27 | 2016-09-28 | 林春梅 | Medicinal dressing and preparation method thereof |
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| CN105769892A (en) * | 2016-04-21 | 2016-07-20 | 蔡敏 | Skin care solution for treating chicken pox and preparation method for skin care solution |
| CN105796574A (en) * | 2016-05-03 | 2016-07-27 | 宋钦 | Care solution for seborrheic dermatitis |
| CN105963756A (en) * | 2016-06-27 | 2016-09-28 | 林春梅 | Medicinal dressing and preparation method thereof |
| CN106822988A (en) * | 2017-02-08 | 2017-06-13 | 中英阿诺康（宁夏）生物科技有限公司 | Alginate fibre functional dressing and its application, alginate fibre functional dressing patch |
| CN106822988B (en) * | 2017-02-08 | 2019-12-31 | 中英阿诺康（宁夏）生物科技有限公司 | Alginate fiber functional dressing and application thereof, and alginate fiber functional dressing patch |
| CN112807322A (en) * | 2019-11-18 | 2021-05-18 | 中国海洋大学 | Application of oligomannuronate in preparing medicine and functional food for delaying skin senility and resisting immune inflammation |
| CN112370464A (en) * | 2019-12-27 | 2021-02-19 | 青岛博智汇力生物科技有限公司 | Marine oligosaccharide composition for treating beriberi |
| CN111407702A (en) * | 2020-04-27 | 2020-07-14 | 威海长青海洋科技股份有限公司 | Skin-care face cream containing sophora flower and seaweed and preparation method of skin-care face cream |
| CN112245332A (en) * | 2020-12-02 | 2021-01-22 | 青岛博智汇力生物科技有限公司 | Eczema gel containing marine oligosaccharide |
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