CN104524255A - Medicament for treatment of "aplastic anemia" combined gum bleeding illness and preparation method - Google Patents

Abstract

The invention discloses a medicament for treatment of "aplastic anemia" combined gum bleeding illness. The medicament is mainly prepared from the following bulk drugs by weight part: 6-9 of gardenia jasminoides charcoal; 10-20 of bamboo shavings; 2-5 of Artemisia anomala; 6-10 of charred human hair; 5-10 of Solidago decurrens; 6-15 of rhizoma bletillae; 5-12 of Stellaria yunnanensis; 9-16 of imperata rhizome; 9-12 of balloonflower root; 10-15 of dandelion; and 6-10 of palm charcoal. The medicament provided by the invention has the characteristics of scientific formula and simple preparation method, is specific to "aplastic anemia" combined gum bleeding illness, is studied for years and has significant effect.

Description

Treatment " aplastic anemia " merges medicament and the preparation method of bleeding from the gum disease

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to medicament and preparation method that treatment " aplastic anemia " merges bleeding from the gum disease.

Background technology

" aplastic anemia " i.e. aplastic anemia, because many reasons causes bone marrow hematogenesis tissue obviously to reduce, bone marrow hematogenesis failure function, classical symptom is: Progressive symmetric erythrokeratodermia anemia, hemorrhage, infect and pancytopenia, the traditional Chinese medical science belongs to " chronic consumptive disease, disorders of blood " category, that causes this disease is generally chemistry, treatment, the factors such as infection, it is white that primary disease often shows yellowish complexion, health is weak, severe palpitation, be easy to flu dizzy, some patients has heating paresthesia, and heating easily repeatedly, skin has petechia, pale tongue, white and thin fur, deep-thready pulse or count accurately, some patients are also had to merge gingival infection, anorectal is scorching, throat is dry itches.Bleeding from the gum, with the hemorrhage disease for main symptom of gingiva slot.Also known as gingival atrophy.Many by flaming up of stomach-fire, burn blood network or deficiency of kidney-YIN, dynamic in asthenic fire, caused by the absurd row of forcing blood.It is dialectical that should to differentiate hemorrhage true genus empty.Different TCM syndrome types has 1. vehement type bleeding from the gum in stomach-fire.General amount of bleeding is more, and color is scarlet, companion's red swelling of gingiva, halitosis, and xerostomia, for drink, is had a headache, constipation, red tongue with yellow fur, slippery and rapid pulse.

Publication No. CN 102274417 A(application number 201110213694.3) Chinese patent literature disclose a kind of Chinese patent medicine for the treatment of aplastic anemia, this Chinese patent medicine mainly contains the compositions such as crude drug Radix Rehmanniae Preparata, Radix Scrophulariae, Radix Ophiopogonis, Rhizoma Alismatis, Folium Mori, Radix Rubiae, Fructus Gardeniae, Cortex Moutan, Rhizoma Imperatae.Publication No. CN 104147349 A(application number 201410404656.X) Chinese patent literature disclose a kind of Chinese medicine composition for the treatment of aplastic anemia.In said composition, each component is as follows by weight ratio: Fructus Lycii 30-40 part, Radix Puerariae 10-20 part, Radix Ginseng Rubra 20-30 part, Radix Glycyrrhizae 30-40 part, Radix Astragali 50-60 part, Radix Polygoni Multiflori 50-60 part, dry Medulla Bovis seu Bubali 50 parts, Crinis Carbonisatus 30-40 part, Colla Corii Asini 80-100 part, Cornu Cervi Degelatinatum 30-40 part, Radix Pseudostellariae 40-50 part, Cordyceps 20-30 part, Radix Salviae Miltiorrhizae 20-30 part, Carapax et Plastrum Testudinis 60-70 part, Radix Ophiopogonis 20-30 part, Rhizoma Alismatis 20-30 part, Flos Lonicerae 60-80 part, spirulina 10-20 part, Pericarpium Granati 30-40 part.Publication No. CN 102727707 A(application number 201110093191.7) Chinese patent literature disclose a kind of pharmaceutical composition for the treatment of leukemia and aplastic anemia, said composition is made up of Radix Rehmanniae Preparata, the Radix Polygoni Multiflori, the Radix Rehmanniae, Cortex Moutan, Radix Angelicae Sinensis, Fructus Forsythiae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Flos Lonicerae, Carapax et Plastrum Testudinis, the Radix Paeoniae Alba, Colla Corii Asini, Radix Glycyrrhizae, Radix Codonopsis, Rhizoma Dioscoreae, Fructus Lycii, Fructus Schisandrae Chinensis, Cornu Bubali, Lignum Sappan, Rhizoma Chuanxiong, Radix Platycodonis and Radix Cyathulae.

In technological means now, the therapy that the treatment of doctor trained in Western medicine to this disease there is no, single financial burden relying on blood transfusion making patients, the traditional Chinese medical science is for this disease, with the obvious advantage, cost is low, good effect, but because of the difference of traditional Chinese medical science theory, cause its curative effect difference comparatively large, therefore also require further study formula.

Summary of the invention

For the problem of prior art, the object of this invention is to provide a kind of Be very effective, take the medicament that the treatment " aplastic anemia " that has no side effect of safety merges bleeding from the gum disease.

Technical scheme of the present invention is:

Treatment " aplastic anemia " merges the medicament of bleeding from the gum disease, is prepared from, is weight portion: Fructus Gardeniae charcoal 6-9 primarily of following bulk drugs; Caulis Bambusae In Taenia 10-20; Herba Artemisiae Anomalae 2-5; Crinis Carbonisatus 6-10; Herba Solidaginis 5-10; Pseudobulbus Bletillae (Rhizoma Bletillae) 6-15; Radix Stellariae Yunnanensis 5-12; Rhizoma Imperatae 9-16; Radix Platycodonis 9-12; Herba Taraxaci 10-15; Charred Petiolus Trachycarpi 6-10.

Preferred version is: Fructus Gardeniae charcoal 7-8; Caulis Bambusae In Taenia 12-18; Herba Artemisiae Anomalae 3-4; Crinis Carbonisatus 7-9; Herba Solidaginis 6-9; Pseudobulbus Bletillae (Rhizoma Bletillae) 9-12; Radix Stellariae Yunnanensis 7-10; Rhizoma Imperatae 11-14; Radix Platycodonis 10-11; Herba Taraxaci 11-14; Charred Petiolus Trachycarpi 7-9.

More preferably: Fructus Gardeniae charcoal 7.5; Caulis Bambusae In Taenia 15; Herba Artemisiae Anomalae 3.5; Crinis Carbonisatus 8; Herba Solidaginis 7.5; Pseudobulbus Bletillae (Rhizoma Bletillae) 10.5; Radix Stellariae Yunnanensis 8.5; Rhizoma Imperatae 12.5; Radix Platycodonis 10.5; Herba Taraxaci 12.5; Charred Petiolus Trachycarpi 8.

Described treatment " aplastic anemia " merges the medicament of bleeding from the gum disease, and be made into pharmaceutically acceptable electuary, its preparation method is:

(1) get Fructus Gardeniae charcoal, Crinis Carbonisatus and charred Petiolus Trachycarpi to smash to pieces, add soak with ethanol, uninterruptedly stir 5-10 minute (preferably: stir 6-9 minute; Be more preferably: stir 8 minutes), leave standstill, filter, heating, drying;

(2) get clean Radix Raphani, pulverize squeeze juice and filter, Caulis Bambusae In Taenia, Radix Platycodonis and Herba Taraxaci are cleaned section, infiltrate 30-40 minute by radish Juice (preferred: to infiltrate 32-38 minute; Be more preferably: infiltrate 35 minutes), take out and put into pot, slow fire heats, and fried dry, taking-up cool;

(3) residue medical material is cleaned cutting, add medical material weight 6-9 water doubly in marmite (preferably: add medical material weight 7-8 water doubly; Be more preferably: the water adding medical material weight 7.5 times), first put into Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Stellariae Yunnanensis and Rhizoma Imperatae, decoct 15 minutes, then add Herba Artemisiae Anomalae and Herba Solidaginis, big fire is boiled, and turns little fiery constantly boiling 25 minutes, filters, obtains filtrate;

(4) medicinal residues repeat to decoct, and amount of water is 6 times of medical material weight, and intense fire is fried open, and fire of larding speech with literary allusions boils 15-25 minute (preferred: slow fire boils 20 minutes), filters and merges twice gained filtrate, then spray dried into powder form;

(5) by step (1) (2) made medical material, pulverized 160 mesh sieves, and mixed with the medicated powder of step (4), then add adjuvant, mix, made granule, drying, packaging made electuary.

Described treatment " aplastic anemia " merges the medicament of bleeding from the gum disease, and in step (5), adjuvant is sucrose, dextrin and medicated powder, and mass ratio is 2:2:1.

Described treatment " aplastic anemia " merges the medicament of bleeding from the gum disease, and be made into pharmaceutically acceptable decoction, its preparation method is:

(1) get Fructus Gardeniae charcoal, Crinis Carbonisatus and charred Petiolus Trachycarpi to smash to pieces, add soak with ethanol, uninterruptedly stir 5-10 minute (preferably: stir 6-9 minute; Be more preferably: stir 8 minutes), leave standstill, filter, heating, drying;

(2) get clean Radix Raphani, pulverize squeeze juice and filter, Caulis Bambusae In Taenia, Radix Platycodonis and Herba Taraxaci are cleaned section, infiltrates 35 minutes by radish Juice, take out and put into pot, slow fire heats, and fried dry, taking-up cool;

(3) residue medical material is cleaned cutting, add medical material weight 6-9 water doubly in marmite (preferably: add medical material weight 7-8 water doubly; Be more preferably: the water adding medical material weight 7.5 times), first put into Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Stellariae Yunnanensis and Rhizoma Imperatae, decoct 15 minutes, then add Herba Artemisiae Anomalae and Herba Solidaginis, big fire is boiled, and turns little fire and endures 25 minutes, filter, obtain filtrate; Medicinal residues add the water of medical material weight 5 times, and after boiling, continuous heating 15 minutes, filters, mixes twice gained filtrate;

(4) by step (1) (2) gained pulverizing medicinal materials, sieve, mix with above-mentioned filtrate, sterilizing encapsulate, obtain decoction.

Described treatment " aplastic anemia " merges the medicament of bleeding from the gum disease, crosses 150-180 mesh sieve (preferred: to cross 160-170 mesh sieve in step (4); Be more preferably: cross 165 mesh sieves).

Described treatment " aplastic anemia " merges the medicament of bleeding from the gum disease, and be made into pharmaceutically acceptable unguentum, its preparation method is:

(1) get Fructus Gardeniae charcoal, Crinis Carbonisatus and charred Petiolus Trachycarpi to smash to pieces, add soak with ethanol, uninterruptedly stir 5-10 minute (preferably: stir 6-9 minute; Be more preferably: stir 8 minutes), leave standstill, filter, heating, drying;

(2) get clean Radix Raphani, pulverize squeeze juice and filter, Caulis Bambusae In Taenia, Radix Platycodonis and Herba Taraxaci are cleaned section, infiltrates 35 minutes by radish Juice, take out and put into pot, slow fire heats, and fried dry, taking-up cool;

(3) residue medical material is cleaned cutting, add medical material weight 6-9 water doubly in marmite (preferably: add medical material weight 7-8 water doubly; Be more preferably: the water adding medical material weight 7.5 times), first put into Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Stellariae Yunnanensis and Rhizoma Imperatae, decoct 15 minutes, then add Herba Artemisiae Anomalae and Herba Solidaginis, big fire is boiled, and turns little fire and endures 25 minutes, filter, obtain filtrate; Medicinal residues add the water of medical material weight 5 times, and after boiling, continuous heating 15 minutes, filters, mixes twice gained filtrate;

(4) by step (1) (2) gained pulverizing medicinal materials, cross 160 mesh sieves, mix with above-mentioned filtrate, concentrating under reduced pressure becomes clear paste, obtains unguentum.

Described treatment " aplastic anemia " merges the medicament of bleeding from the gum disease, and in step (4), the relative density of clear paste is 1.20-1.28(70 DEG C) (preferred: relative density is 1.22-1.26(70 DEG C); Be more preferably: relative density is 1.24(70 DEG C)).

Described treatment " aplastic anemia " merges the medicament of bleeding from the gum disease, and be made into pharmaceutically acceptable honeyed pill, its preparation method is:

(1) get Fructus Gardeniae charcoal, Crinis Carbonisatus and charred Petiolus Trachycarpi to smash to pieces, add soak with ethanol, uninterruptedly stir 5-10 minute (preferably: stir 6-9 minute; Be more preferably: stir 8 minutes), leave standstill, filter, heating, drying;

(2) get clean Radix Raphani, pulverize squeeze juice and filter, Caulis Bambusae In Taenia, Radix Platycodonis and Herba Taraxaci are cleaned section, infiltrates 35 minutes by radish Juice, take out and put into pot, slow fire heats, and fried dry, taking-up cool;

(3) residue medical material is cleaned, run through, be cut into segment, constant temperature drying, with step (1) (2) gained medical material, jointly pulverize, cross 100-130 mesh sieve (preferred: to cross 110-120 mesh sieve; Be more preferably: cross 115 mesh sieves);

(4) medicated powder mixed with refined honey, fully with even, make strip, be divided into ball, pack and make honeyed pill.

Described treatment " aplastic anemia " merges the medicament of bleeding from the gum disease, and it is 1:1.5 that step (4) Chinese medicine powder and refined honey obtain ratio.

The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:

Fructus Gardeniae charcoal: SHANZHIZI: base is former: the dry mature fruit of Maguireothamnus speciosus Fructus Gardeniae, its root also can be used as medicine.Nature and flavor: bitter, cold.Gui Jing: enter heart channel, Liver Channel, lung meridian, stomach warp.Function cures mainly: heat clearing away, pathogenic fire purging, removing heat from blood.Control calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quench one's thirst, conjunctival congestion, pharyngalgia, spit blood, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprains and swells and ache.Classed FRUCTUS GARDENIAE: get the SHANZHIZI of pulverizing, put in pot and fry to pitchy with high heat, but palpus sustainability, take out, cool.

Caulis Bambusae In Taenia: base is former: the intermediate layer that the stem stalk for grass family Phyllostachys plant phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle, the blue or green pole bamboo of Thorny Sinobambusa plant, Sinocalamus plant major part allusion quotation bamboo etc. goes crust to scrape.Composition: the Caulis Bambusae In Taenia of phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle is containing phenolic constituent: 2,5-dimethoxy-1,4-benzoquinone, hydroxy benzaldehyde, syringic aldehyde, coniferyl aldehyde.Another containing p-phthalic acid 2 '-hydroxyethyl methyl ester.The property of medicine: sweet, is slightly cold.Return spleen, stomach, gallbladder meridian.Function cures mainly: removing heat-phlegm, relieves restlessness and prevents vomiting, safe and sound removing heat from blood.Cure mainly cough due to lung-heat, dysphoria with smothery sensation is palpitated with fear, and gastric heat is vomitted oh, pregnancy reactions, frequent fetal movement, spits blood, epistaxis, hematuria, metrorrhagia.

Herba Artemisiae Anomalae: have another name called Herba Artemisiae Anomalae grass, Herba Senecionis Scandentis is the wounded in the battle herb of Compositae sagebruss artemisia anomalas.The property of medicine: stem is cylindrical, surperficial brown color or brown-green, matter is hard and crisp, frangibility, the integrated spike panicle of head inflorescence, withered yellow, gas fragrance, bitter in the mouth, pungent, warm in nature.Composition: mainly containing arteanoflavone, tricin, apigenin, Palmic acid etc.Find according to modern pharmacological research, this medical instrument has effect of anti-hypoxia, blood circulation promoting and blood stasis dispelling, removing food stagnancy, hemostasia and detumescence, for amenorrhea due to stagnation of blood, and abdominal pain due to retention of food, hematuria, the diseases such as scald.

Crinis Carbonisatus: base is former: the carbide made for Crinis Carbonisatus.Get hair, removing impurity, aqueous alkali washes away grease, and clear water rinses, and dries, and boils in a covered pot over a slow fire and forges into charcoal, cool.Nature and flavor with return through: bitter, flat.Return liver, stomach warp.Function with cure mainly: astringing to arrest bleeding, blood stasis dispelling, diuresis.For spitting blood, spitting of blood, epistaxis, stranguria with blood, hematuria, has blood in stool, metrorrhagia, traumatic hemorrhage, dysuria.

Herba Solidaginis: base is former: be herb or the root of Compositae Herba Solidaginis platymiscium Herba Solidaginis.Composition: aerial parts is containing saponin component: Herba Solidaginis glycosides, activities of Solidago virgaurea L saponin 3 that is 3, Solidago saponin, solidago canadesis saponin, huge Herba Solidaginis saponin, the triterpene glycosides etc. of Polygalacic acid.The property of medicine: pungent, bitter, cool.Function cures mainly: wind and heat dispersing, removing toxic substances and promoting subsidence of swelling.Cure mainly anemopyretic cold, laryngopharynx swelling and pain, cough due to lung-heat, jaundice, pyretic stranguria, carbuncle furuncle, venom, traumatic injury.Compatibility and incompatibility of drugs: " Guangdong Chinese medicine ": " can not decoct for a long time, decoct nauseating for a long time.”

Pseudobulbus Bletillae (Rhizoma Bletillae): base is former: for orchid from and dry tuber.Nature and flavor with return through: bitter, sweet, puckery, be slightly cold.Return lung, liver, stomach warp.Function with cure mainly: astringing to arrest bleeding, detumescence and promoting granulation.For spitting of blood, spit blood, traumatic hemorrhage, sore swollen toxin, chapped skin.

Radix Stellariae Yunnanensis: another name wheat ginseng, Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), large Herba malachii aquatici.Base is former: be the root of pinkwort Yunnan Herba stellariae mediae.Summer, autumn gather.Nature and flavor: sweet; Property is put down.Gui Jing: liver; Spleen; Kidney channel.Function cures mainly: strengthening spleen and nourishing blood; The liver and the kidney tonifying; Detumescence.Main anemia; Spirit is deficient; Dizzy nervous; Tinnitus dim eyesight; Hectic fever; Seminal emission; Menoxenia; Leukorrhagia; Fracture; Mastitis.

Rhizoma Imperatae: nature and flavor with return through: sweet, cold.Return lung, stomach, urinary bladder channel.There is cooling blood for hemostasis, effect of clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice due to damp-heat, edema oliguria, the puckery pain of pyretic stranguria.

Radix Platycodonis: nature and flavor: bitter, pungent is flat.Gui Jing: return lung meridian.Effect: lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.Cure mainly: for cough with copious phlegm, uncomfortable in chest smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.

Herba Taraxaci: nature and flavor with return through: bitter, sweet, cold.Return liver, stomach warp.Function with cure mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.

Charred Petiolus Trachycarpi: Petiolus Trachycarpi: nature and flavor with return through: bitter, puckery, flat.Return lung, liver, large intestine channel.Function with cure mainly: astringing to arrest bleeding.For spitting blood, epistaxis, hematuria, has blood in stool, metrorrhagia.Charred Petiolus Trachycarpi: get clean Petiolus Trachycarpi, according to the charcoal processing of charcoal (calcined) method, it is irregular bulk, not of uniform size.Surface pitchy is to black, glossy, has vertical vertical bar stricture of vagina; That touches has black powdered carbon.Inner coke yellow, fibroid.Somewhat burnt odor gas, bitter and puckery flavor.

Treatment provided by the invention " aplastic anemia " merges the reagent combination science of bleeding from the gum disease, and preparation method is simple.In addition, its excellent part also shows:

1, the present invention is directed to " aplastic anemia " and merge bleeding from the gum disease, study for many years, Be very effective;

2, the medical material selected by this prescription is with low cost, does not increase the burden of patient;

3, the various dosage form of gained of the present invention, taking convenience, safety has no side effect.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.

embodiment 1treatment " aplastic anemia " merges the medicament of bleeding from the gum disease, is prepared from: Fructus Gardeniae charcoal 6g, Caulis Bambusae In Taenia 10g, Herba Artemisiae Anomalae 2g, Crinis Carbonisatus 6g, Herba Solidaginis 5g, Pseudobulbus Bletillae (Rhizoma Bletillae) 6g, Radix Stellariae Yunnanensis 5g, Rhizoma Imperatae 9g, Radix Platycodonis 9g, Herba Taraxaci 10g, charred Petiolus Trachycarpi 6g primarily of following bulk drugs.The preparation method that above-mentioned treatment " aplastic anemia " merges the electuary of bleeding from the gum disease is:

(1) get Fructus Gardeniae charcoal, Crinis Carbonisatus and charred Petiolus Trachycarpi to smash to pieces, add soak with ethanol, uninterrupted stirring 6 minutes, leave standstill, filter, heating, drying;

(2) get clean Radix Raphani, pulverize squeeze juice and filter, Caulis Bambusae In Taenia, Radix Platycodonis and Herba Taraxaci are cleaned section, infiltrates 32 minutes by radish Juice, take out and put into pot, slow fire heats, and fried dry, taking-up cool;

(3) residue medical material is cleaned cutting, add the water of medical material weight 7 times, first put into Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Stellariae Yunnanensis and Rhizoma Imperatae in marmite, decoct 15 minutes, then add Herba Artemisiae Anomalae and Herba Solidaginis, big fire is boiled, and turns little fiery constantly boiling 25 minutes, filters, obtains filtrate;

(4) medicinal residues repeat to decoct, and amount of water is 6 times of medical material weight, and intense fire is fried open, and fire of larding speech with literary allusions boils 15 minutes, filters and merges twice gained filtrate, then spray dried into powder form;

(5) by step (1) (2) made medical material, pulverized 160 mesh sieves, mixed with the medicated powder of step (4), then added adjuvant (mass ratio of sucrose, dextrin and medicated powder is 2:2:1), mixed, made granule, drying, packaging made electuary.

embodiment 2treatment " aplastic anemia " merges the medicament of bleeding from the gum disease, is prepared from: Fructus Gardeniae charcoal 9g, Caulis Bambusae In Taenia 20g, Herba Artemisiae Anomalae 5g primarily of following bulk drugs, Crinis Carbonisatus 10g, Herba Solidaginis 10g, Pseudobulbus Bletillae (Rhizoma Bletillae) 15g, Radix Stellariae Yunnanensis 12g, Rhizoma Imperatae 16g, Radix Platycodonis 12g, Herba Taraxaci 15g, charred Petiolus Trachycarpi 10g.The preparation method that above-mentioned treatment " aplastic anemia " merges the decoction of bleeding from the gum disease is:

(1) get Fructus Gardeniae charcoal, Crinis Carbonisatus and charred Petiolus Trachycarpi to smash to pieces, add soak with ethanol, uninterrupted stirring 8 minutes, leave standstill, filter, heating, drying;

(2) get clean Radix Raphani, pulverize squeeze juice and filter, Caulis Bambusae In Taenia, Radix Platycodonis and Herba Taraxaci are cleaned section, infiltrates 35 minutes by radish Juice, take out and put into pot, slow fire heats, and fried dry, taking-up cool;

(3) residue medical material is cleaned cutting, add the water of medical material weight 7.5 times, first put into Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Stellariae Yunnanensis and Rhizoma Imperatae in marmite, decoct 15 minutes, then add Herba Artemisiae Anomalae and Herba Solidaginis, big fire is boiled, and turns little fire and endures 25 minutes, filter, obtain filtrate; Medicinal residues add the water of medical material weight 5 times, and after boiling, continuous heating 15 minutes, filters, mixes twice gained filtrate;

(4) by step (1) (2) gained pulverizing medicinal materials, excessively 165 mesh sieves, mix with above-mentioned filtrate, sterilizing encapsulates, and obtains decoction.

Model case: xxx, women, 34 years old.Main suit: because of gingival hemorrhage, malaise, listless medical.Medical history: patient, before three months, occurs dizzy, weak symptom without obvious inducement, and with gingival hemorrhage, hemorrhage comparatively obvious in the recent period, insomnia and dreamful sleep, body of the tongue are light red, thready and rapid pulse.On inspection, platelet 14 × 109/L, hemoglobin: 19g/l, is diagnosed as aplastic anemia and bleeding from the gum.

Take this example gained decoction, twice daily, a 80-100ml ten days is a course for the treatment of.After taking one month, patient's bleeding symptom alleviates, and malaise symptoms is improved, and continues to take two courses for the treatment of, and substantially not hemorrhage, weak, listless state obviously alleviates, and self-induction is fully recovered.

embodiment 3treatment " aplastic anemia " merges the medicament of bleeding from the gum disease, is prepared from: Fructus Gardeniae charcoal 7g, Caulis Bambusae In Taenia 12g, Herba Artemisiae Anomalae 3g primarily of following bulk drugs, Crinis Carbonisatus 7g, Herba Solidaginis 6g, Pseudobulbus Bletillae (Rhizoma Bletillae) 9g, Radix Stellariae Yunnanensis 7g, Rhizoma Imperatae 11g, Radix Platycodonis 10g, Herba Taraxaci 11g, charred Petiolus Trachycarpi 7g.The preparation method that above-mentioned treatment " aplastic anemia " merges the unguentum of bleeding from the gum disease is:

(1) get Fructus Gardeniae charcoal, Crinis Carbonisatus and charred Petiolus Trachycarpi to smash to pieces, add soak with ethanol, uninterrupted stirring 8 minutes, leave standstill, filter, heating, drying;

(2) get clean Radix Raphani, pulverize squeeze juice and filter, Caulis Bambusae In Taenia, Radix Platycodonis and Herba Taraxaci are cleaned section, infiltrates 35 minutes by radish Juice, take out and put into pot, slow fire heats, and fried dry, taking-up cool;

(3) residue medical material is cleaned cutting, add the water of medical material weight 7.5 times, first put into Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Stellariae Yunnanensis and Rhizoma Imperatae in marmite, decoct 15 minutes, then add Herba Artemisiae Anomalae and Herba Solidaginis, big fire is boiled, and turns little fire and endures 25 minutes, filter, obtain filtrate; Medicinal residues add the water of medical material weight 5 times, and after boiling, continuous heating 15 minutes, filters, mixes twice gained filtrate;

(4) by step (1) (2) gained pulverizing medicinal materials, cross 160 mesh sieves, mix with above-mentioned filtrate, concentrating under reduced pressure becomes relative density to be 1.24(70 DEG C) clear paste, obtain unguentum.

Model case: xxx, male, 23 years old.There is gingival hemorrhage phenomenon because of intermittence in patient, and has gradual weak, dizzy heating paresthesia, and remove hospital admission after first quarter moon, find on inspection, leukocyte 0.40 × 109/L, red pigment 79g/L, platelet 10 × 109/L, is diagnosed as aplastic anemia.

Taking this example gained unguentum, each two soup ladles (about about 5g), warm boiled water, one day twice, ten days is a course for the treatment of.Patient takes three courses for the treatment of, and hemogram rises gradually, and blood transfusion number of times obviously reduces, and after continuing to take a course for the treatment of, malaise symptoms is all eliminated, and hemogram recovers normal, follows up a case by regular visits to a year and a half, without recurrence.

embodiment 4treatment " aplastic anemia " merges the medicament of bleeding from the gum disease, is prepared from: Fructus Gardeniae charcoal 8g, Caulis Bambusae In Taenia 18g, Herba Artemisiae Anomalae 4g primarily of following bulk drugs, Crinis Carbonisatus 9g, Herba Solidaginis 9g, Pseudobulbus Bletillae (Rhizoma Bletillae) 12g, Radix Stellariae Yunnanensis 10g, Rhizoma Imperatae 14g, Radix Platycodonis 11g, Herba Taraxaci 14g, charred Petiolus Trachycarpi 9g.The preparation method that above-mentioned treatment " aplastic anemia " merges the honeyed pill of bleeding from the gum disease is:

(1) get Fructus Gardeniae charcoal, Crinis Carbonisatus and charred Petiolus Trachycarpi to smash to pieces, add soak with ethanol, uninterrupted stirring 8 minutes, leave standstill, filter, heating, drying;

(2) get clean Radix Raphani, pulverize squeeze juice and filter, Caulis Bambusae In Taenia, Radix Platycodonis and Herba Taraxaci are cleaned section, infiltrates 35 minutes by radish Juice, take out and put into pot, slow fire heats, and fried dry, taking-up cool;

(3) residue medical material is cleaned, run through, be cut into segment, constant temperature drying, with step (1) (2) gained medical material, jointly pulverize, cross 115 mesh sieves;

(4) medicated powder mixed with the ratio of refined honey according to 1:1.5, fully with even, make strip, be divided into ball, pack and make honeyed pill.

Model case: xxx, women, 41 years old.Medical history: patient obtains aplastic anemia 3 years, yellowish complexion, weak, conscious nervous, uncomfortable in chest after slight work, and with symptoms such as gingival hemorrhage, aversion to cold and cold limbs, poor appetite insomnia and heatings, the traditional Chinese medical science checks light red tongue yellow fur, thready pulse, must time need to transfuse blood.

Introduce through friend, taking this example gained honeyed pill, each three (2g/ grain), one day twice, ten days is a course for the treatment of.After taking four courses for the treatment of, malaise symptoms be improved significantly, hemorrhage minimizing, after continuing to strengthen two courses for the treatment of, substantially not hemorrhage, routine blood indexes is normal.

embodiment 5treatment " aplastic anemia " merges the medicament of bleeding from the gum disease, is prepared from: Fructus Gardeniae charcoal 7.5g, Caulis Bambusae In Taenia 15g, Herba Artemisiae Anomalae 3.5g primarily of following bulk drugs, Crinis Carbonisatus 8g, Herba Solidaginis 7.5g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10.5g, Radix Stellariae Yunnanensis 8.5g, Rhizoma Imperatae 12.5g, Radix Platycodonis 10.5g, Herba Taraxaci 12.5g, charred Petiolus Trachycarpi 8g.The preparation method that above-mentioned treatment " aplastic anemia " merges the electuary of bleeding from the gum disease is:

(1) get Fructus Gardeniae charcoal, Crinis Carbonisatus and charred Petiolus Trachycarpi to smash to pieces, add soak with ethanol, uninterrupted stirring 8 minutes, leave standstill, filter, heating, drying;

(2) get clean Radix Raphani, pulverize squeeze juice and filter, Caulis Bambusae In Taenia, Radix Platycodonis and Herba Taraxaci are cleaned section, infiltrates 35 minutes by radish Juice, take out and put into pot, slow fire heats, and fried dry, taking-up cool;

(3) residue medical material is cleaned cutting, add the water of medical material weight 7.5 times in marmite, first put into Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Stellariae Yunnanensis and Rhizoma Imperatae, decoct 15 minutes, then add Herba Artemisiae Anomalae and Herba Solidaginis, big fire is boiled, turn little fiery constantly boiling 25 minutes, filter, obtain filtrate;

(4) medicinal residues repeat to decoct, and amount of water is 6 times of medical material weight, and intense fire is fried open, and fire of larding speech with literary allusions boils 20 minutes, filters and merges twice gained filtrate, then spray dried into powder form;

(5) by step (1) (2) made medical material, pulverized 160 mesh sieves, mixed with the medicated powder of step (4), then added adjuvant (mass ratio of sucrose, dextrin and medicated powder is 2:2:1), mixed, made granule, drying, packaging made electuary.

test example 1embodiment 5 gained treatment " aplastic anemia " merges the clinical practice of the medicament electuary of bleeding from the gum disease: according to hospital outpatient case history, screening patient 298 example, wherein women 168 example, male 130 example, oldest 58 years old, minimum 15 years old, 30.5 years old mean age.Before test, Continuous Observation is carried out to this crowd, record symptom and change.

Inclusive criteria: gingival hemorrhage, dizzy, weak, the clinical uncomfortable disease such as pale complexion or heating, blood routine examination: below hemoglobin 70g/L, leukocyte 3.0 × below 10g/L, erythrocyte 2.0 × below 10H/L, platelet 60 × below 10H/L.

Test method: experimental group takes embodiment five gained electuary, and every day takes twice, a 5g/ bag, warm boiled water ten days is a course for the treatment of; Matched group takes other conventional medicines (as such as Xue-bao capsules, ZAIZAOSHENGXUE PIAN, FUFANG ZAOFAN WAN etc.).

Curative effect determinate standard: recovery from illness: clinical uncomfortable disease is eliminated, without hemorrhage, routine blood indexes recovers normal; Effective: clinical uncomfortable disease makes moderate progress, and times of bleeding obviously declines, and routine blood test is normal; Invalid: before and after treatment, symptom is unchanged.

Clinical effectiveness is as shown in table 1:

Can be obtained by table 1, after treating four courses for the treatment of, the patient that in experimental group, bleeding improves, uncomfortable disease alleviates can reach 95.9%, higher than 86% of matched group, and does not occur recurrence after treatment, illustrates that the therapeutic effect that the present invention merges bleeding from the gum disease to " aplastic anemia " is remarkable.

Caulis Bambusae In Taenia has been selected: clearing away heat and cooling blood in formula of the present invention; Pseudobulbus Bletillae (Rhizoma Bletillae): astringing to arrest bleeding; Rhizoma Imperatae: cooling blood for hemostasis; Radix Platycodonis: lung qi dispersing, evacuation of pus; Herba Taraxaci: dispersing swelling and dissipating binds, add accessory drugs Fructus Gardeniae charcoal, Herba Solidaginis, Radix Stellariae Yunnanensis etc., all medicines share, and treat targetedly, have obvious therapeutic effect to the malaise symptoms such as hemorrhage, dizzy weak that " aplastic anemia " merges that bleeding from the gum causes.

It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. treat the medicament that " aplastic anemia " merges bleeding from the gum disease, it is characterized in that, be prepared from primarily of following bulk drugs, be weight portion: Fructus Gardeniae charcoal 6-9; Caulis Bambusae In Taenia 10-20; Herba Artemisiae Anomalae 2-5; Crinis Carbonisatus 6-10; Herba Solidaginis 5-10; Pseudobulbus Bletillae (Rhizoma Bletillae) 6-15; Radix Stellariae Yunnanensis 5-12; Rhizoma Imperatae 9-16; Radix Platycodonis 9-12; Herba Taraxaci 10-15; Charred Petiolus Trachycarpi 6-10.

2. treat the medicament that " aplastic anemia " merges bleeding from the gum disease as claimed in claim 1, it is characterized in that, Fructus Gardeniae charcoal 7-8; Caulis Bambusae In Taenia 12-18; Herba Artemisiae Anomalae 3-4; Crinis Carbonisatus 7-9; Herba Solidaginis 6-9; Pseudobulbus Bletillae (Rhizoma Bletillae) 9-12; Radix Stellariae Yunnanensis 7-10; Rhizoma Imperatae 11-14; Radix Platycodonis 10-11; Herba Taraxaci 11-14; Charred Petiolus Trachycarpi 7-9(is preferably: Fructus Gardeniae charcoal 7.5; Caulis Bambusae In Taenia 15; Herba Artemisiae Anomalae 3.5; Crinis Carbonisatus 8; Herba Solidaginis 7.5; Pseudobulbus Bletillae (Rhizoma Bletillae) 10.5; Radix Stellariae Yunnanensis 8.5; Rhizoma Imperatae 12.5; Radix Platycodonis 10.5; Herba Taraxaci 12.5; Charred Petiolus Trachycarpi 8).

3. the treatment " aplastic anemia " as described in as arbitrary in claim 1-2 merges the medicament of bleeding from the gum disease, and it is characterized in that, be made into pharmaceutically acceptable electuary, its preparation method is:

(1) get Fructus Gardeniae charcoal, Crinis Carbonisatus and charred Petiolus Trachycarpi to smash to pieces, add soak with ethanol, uninterruptedly stir 5-10 minute (preferably: stir 6-9 minute; Be more preferably: stir 8 minutes), leave standstill, filter, heating, drying;

(2) get clean Radix Raphani, pulverize squeeze juice and filter, Caulis Bambusae In Taenia, Radix Platycodonis and Herba Taraxaci are cleaned section, infiltrate 30-40 minute by radish Juice (preferred: to infiltrate 32-38 minute; Be more preferably: infiltrate 35 minutes), take out and put into pot, slow fire heats, and fried dry, taking-up cool;

(3) residue medical material is cleaned cutting, add medical material weight 6-9 water doubly in marmite (preferably: add medical material weight 7-8 water doubly; Be more preferably: the water adding medical material weight 7.5 times), first put into Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Stellariae Yunnanensis and Rhizoma Imperatae, decoct 15 minutes, then add Herba Artemisiae Anomalae and Herba Solidaginis, big fire is boiled, and turns little fiery constantly boiling 25 minutes, filters, obtains filtrate;

(4) medicinal residues repeat to decoct, and amount of water is 6 times of medical material weight, and intense fire is fried open, and fire of larding speech with literary allusions boils 15-25 minute (preferred: slow fire boils 20 minutes), filters and merges twice gained filtrate, then spray dried into powder form;

(5) by step (1) (2) made medical material, pulverized 160 mesh sieves, and mixed with the medicated powder of step (4), then add adjuvant, mix, made granule, drying, packaging made electuary.

4. treat the preparation method that " aplastic anemia " merges the medicament of bleeding from the gum disease as claimed in claim 3, it is characterized in that, in step (5), adjuvant is sucrose, dextrin and medicated powder, and mass ratio is 2:2:1.

5. the treatment " aplastic anemia " as described in as arbitrary in claim 1-2 merges the medicament of bleeding from the gum disease, and it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:

(1) get Fructus Gardeniae charcoal, Crinis Carbonisatus and charred Petiolus Trachycarpi to smash to pieces, add soak with ethanol, uninterruptedly stir 5-10 minute (preferably: stir 6-9 minute; Be more preferably: stir 8 minutes), leave standstill, filter, heating, drying;

(2) get clean Radix Raphani, pulverize squeeze juice and filter, Caulis Bambusae In Taenia, Radix Platycodonis and Herba Taraxaci are cleaned section, infiltrates 35 minutes by radish Juice, take out and put into pot, slow fire heats, and fried dry, taking-up cool;

(3) residue medical material is cleaned cutting, add medical material weight 6-9 water doubly in marmite (preferably: add medical material weight 7-8 water doubly; Be more preferably: the water adding medical material weight 7.5 times), first put into Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Stellariae Yunnanensis and Rhizoma Imperatae, decoct 15 minutes, then add Herba Artemisiae Anomalae and Herba Solidaginis, big fire is boiled, and turns little fire and endures 25 minutes, filter, obtain filtrate; Medicinal residues add the water of medical material weight 5 times, and after boiling, continuous heating 15 minutes, filters, mixes twice gained filtrate;

(4) by step (1) (2) gained pulverizing medicinal materials, sieve, mix with above-mentioned filtrate, sterilizing encapsulate, obtain decoction.

6. treat the preparation method that " aplastic anemia " merges the medicament of bleeding from the gum disease as claimed in claim 5, it is characterized in that, cross 150-180 mesh sieve in step (4) (preferred: to cross 160-170 mesh sieve; Be more preferably: cross 165 mesh sieves).

7. the treatment " aplastic anemia " as described in as arbitrary in claim 1-2 merges the medicament of bleeding from the gum disease, and it is characterized in that, be made into pharmaceutically acceptable unguentum, its preparation method is:

(1) get Fructus Gardeniae charcoal, Crinis Carbonisatus and charred Petiolus Trachycarpi to smash to pieces, add soak with ethanol, uninterruptedly stir 5-10 minute (preferably: stir 6-9 minute; Be more preferably: stir 8 minutes), leave standstill, filter, heating, drying;

(2) get clean Radix Raphani, pulverize squeeze juice and filter, Caulis Bambusae In Taenia, Radix Platycodonis and Herba Taraxaci are cleaned section, infiltrates 35 minutes by radish Juice, take out and put into pot, slow fire heats, and fried dry, taking-up cool;

(3) residue medical material is cleaned cutting, add medical material weight 6-9 water doubly in marmite (preferably: add medical material weight 7-8 water doubly; Be more preferably: the water adding medical material weight 7.5 times), first put into Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Stellariae Yunnanensis and Rhizoma Imperatae, decoct 15 minutes, then add Herba Artemisiae Anomalae and Herba Solidaginis, big fire is boiled, and turns little fire and endures 25 minutes, filter, obtain filtrate; Medicinal residues add the water of medical material weight 5 times, and after boiling, continuous heating 15 minutes, filters, mixes twice gained filtrate;

(4) by step (1) (2) gained pulverizing medicinal materials, cross 160 mesh sieves, mix with above-mentioned filtrate, concentrating under reduced pressure becomes clear paste, obtains unguentum.

8. treat the preparation method that " aplastic anemia " merges the medicament of bleeding from the gum disease as claimed in claim 7, it is characterized in that, in step (4), the relative density of clear paste is 1.20-1.28(70 DEG C) (preferred: relative density is 1.22-1.26(70 DEG C); Be more preferably: relative density is 1.24(70 DEG C)).

9. the treatment " aplastic anemia " as described in as arbitrary in claim 1-2 merges the medicament of bleeding from the gum disease, and it is characterized in that, be made into pharmaceutically acceptable honeyed pill, its preparation method is:

(1) get Fructus Gardeniae charcoal, Crinis Carbonisatus and charred Petiolus Trachycarpi to smash to pieces, add soak with ethanol, uninterruptedly stir 5-10 minute (preferably: stir 6-9 minute; Be more preferably: stir 8 minutes), leave standstill, filter, heating, drying;

(2) get clean Radix Raphani, pulverize squeeze juice and filter, Caulis Bambusae In Taenia, Radix Platycodonis and Herba Taraxaci are cleaned section, infiltrates 35 minutes by radish Juice, take out and put into pot, slow fire heats, and fried dry, taking-up cool;

(3) residue medical material is cleaned, run through, be cut into segment, constant temperature drying, with step (1) (2) gained medical material, jointly pulverize, cross 100-130 mesh sieve (preferred: to cross 110-120 mesh sieve; Be more preferably: cross 115 mesh sieves);

(4) medicated powder mixed with refined honey, fully with even, make strip, be divided into ball, pack and make honeyed pill.

10. treat the preparation method that " aplastic anemia " merges the medicament of bleeding from the gum disease as claimed in claim 9, it is characterized in that, it is 1:1.5 that step (4) Chinese medicine powder and refined honey obtain ratio.