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CN104524230A - Medicine for conditioning lobar pneumonia in restoration stage and preparation method of medicine - Google Patents

Medicine for conditioning lobar pneumonia in restoration stage and preparation method of medicine Download PDF

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CN104524230A
CN104524230A CN201510052822.9A CN201510052822A CN104524230A CN 104524230 A CN104524230 A CN 104524230A CN 201510052822 A CN201510052822 A CN 201510052822A CN 104524230 A CN104524230 A CN 104524230A
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medicine
radix
herba
semen
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王新
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    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
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    • A61K36/06—Fungi, e.g. yeasts
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
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Abstract

The invention discloses a medicine for conditioning lobar pneumonia in a restoration stage and a preparation method of the medicine. The medicine is prepared from the following medicinal raw materials: saxifraga stolonifera, sculellaria barbata, arcangelisia loureiri, stephania, polygonum convolvulus, herb of little platanthera, seeds of Chinese waxgourds, perny false fairybells rhizome, Chinese ladiestresses roots or herb, bitter calabash, spina date seeds, poria cocos, dioscorea hemsleyi, phoenix tree seeds and cortex lycii radicis. The medicine disclosed by the invention has the beneficial effects that the medicine, which take the functions of expelling retained toxin and invigorating qi and moisturizing lung, as a main treatment principle and inflicts on the functions of phlegm and benefiting lung, clearing damp and tonifying spleen and helping digestion and harmonizing stomach, has the advantages of being good in effect, quick to teak effect, free of toxic and side effects and having small possibility of relapse when being used for patients needing conditioning lobar pneumonia in the restoration stage.

Description

For medicine that lobar pneumonia convalescent period nurses one's health and preparation method thereof
Technical field
The present invention relates to pharmaceutical technology, particularly relate to a kind of medicine for the conditioning of lobar pneumonia convalescent period and preparation method thereof.
Background technology
Lobar pneumonia, has another name called pneumococcal pneumonia, is the pulmonary's acute inflammation distributed in great Ye caused by bacteriological infection such as Diplococcus pneumoniaes.Common inducement is suffered from cold, tired or drench with rain.Belong to the category such as the traditional Chinese medical science " pathogenic wind-warm ", " pulmonary distension ".It is the acute pulmonary parenchyma inflammation caused by Diplococcus pneumoniae.Be apt to occur in male adults and winter-spring season.Common inducement is caught cold, drench with rain, after drunk or General anesthesia, tranquilizer is excessive etc.Main pathology changes into exudative inflammation and the consolidation of alveolar.Clinical symptoms has unexpected shiver with cold, high heat, cough, chest pain, coughs rusty expectoration.
Various bacteria all can cause lobar pneumonia, but the overwhelming majority is streptococcus pneumoniae, wherein the strongest with III type pathogenicity.Streptococcus pneumoniae is the normal parasitic flora of oral cavity and nasopharynx part, if when the resistance of the discharge of bacteria self-purification function of respiratory tract and body is normal, do not cause pneumonia.
Clinical manifestation is by the following aspects: 1. onset is hurried, shiver with cold, high heat, chest pain, coughs, coughs rusty expectoration.The extensive person of pathological changes can accompany tachypnea and cyanosis.2. some cases has Nausea and vomiting, abdominal distention, diarrhoea.3. serious symptom person can have neuropsychic symptom, as dysphoria, delirium etc.Also exhaustion can occur, accompanying infection is suffered a shock, and claims shock type (or toxic) pneumonia.4. face of acute ill, rapid breathing, flaring of nares.There are herpes in some patients lip and nose week.5. stage of congestion physical signs of lung presents local respiratory activity degree and weakens, and vocal fremitus slightly strengthens, dull percussion note, can listen and crepitation.Can there be typical sign the consolidation phase, and as Ipsilateral respiratory movement weakens, voice resonance, vocal fremitus strengthen, dull percussion note or flatness, auscultation pathologic bronchial breathing sound; The percussion of dissipation phase gradually becomes sore throat relieving, and bronchial breathing sound also weakens gradually and replaces moist rales.
According to the clinical manifestation of lobar pneumonia, general phase, poisoning phase and convalescent period can be divided in its pathological process, wherein convalescent period and pathological changes later stage, lobar pneumonia is in pathological changes later stage and convalescent period process, the performance of normal and weakness of the spleen and stomach multiple in cloudy liquid, Symptoms is: pathogenic heat go down, and remaining heresy is not use up, because it is hot for a long time, consumption of YIN-fluid, is shown in low grade fever, xerostomia by disease, time have dry cough night sweat, anorexia, red tongue tongue are few, thready pulse.At present, the antibiotic that adopts is treated more, but re-uses effects of antibiotics and not obvious in convalescent period, and easily develops immunity to drugs, and incidence of recurrences increases.
Summary of the invention
The present invention will separate exhausted technical problem and be, a kind of medicine for the conditioning of lobar pneumonia convalescent period and preparation method thereof is provided, wherein, this medicine with expelling remnant toxicity, QI invigorating lung moistening for primary treatment principle, hold concurrently with expectoration profit lung, damp eliminating spleen invigorating, help digestion stomach function regulating, the advantage conditioning lobar pneumonia convalescent patient, there is effective, instant effect, having no side effect and not easily recur.
In order to solve the problems of the technologies described above, the invention provides a kind of medicine for the conditioning of lobar pneumonia convalescent period, it is characterized in that, described medicine comprises following raw medicinal material: Herba Saxifragae, Herba Scutellariae Barbatae, Caulis Arcangelisiae, Radix Stephaniae Japonicae, Radix Et Rhizoma Fagopyri Tatarici, Herba platantherae minoris, Semen Benincasae, Rhizoma disporopsis pernyi, Radix seu Herba Spiranthis Lanceae, Pericarpium Lagenariae sicerariae, Semen Ziziphi Spinosae, Poria, Radix dioscoreae subcalvae, Semen Firmianae and Cortex Lycii.
Described medicine is preferably made up of the raw medicinal material of following parts by weight: Herba Saxifragae 5-8 weight portion, Herba Scutellariae Barbatae 12-23 weight portion, Caulis Arcangelisiae 12-25 weight portion, Radix Stephaniae Japonicae 12-25 weight portion, Radix Et Rhizoma Fagopyri Tatarici 3-7 weight portion, Herba platantherae minoris 10-20 weight portion, Semen Benincasae 15-25 weight portion, Rhizoma disporopsis pernyi 12-18 weight portion, Radix seu Herba Spiranthis Lanceae 10-20 weight portion, Pericarpium Lagenariae sicerariae 12-20 weight portion, Semen Ziziphi Spinosae 17-28 weight portion, Poria 15-28 weight portion, Radix dioscoreae subcalvae 12-19 weight portion, Semen Firmianae 15-20 weight portion and Cortex Lycii 12-18 weight portion.
Described medicine can also be preferably made up of the raw medicinal material of following parts by weight: Herba Saxifragae 6 weight portion, Herba Scutellariae Barbatae 17 weight portion, Caulis Arcangelisiae 18 weight portion, Radix Stephaniae Japonicae 16 weight portion, Radix Et Rhizoma Fagopyri Tatarici 4 weight portion, Herba platantherae minoris 15 weight portion, Semen Benincasae 21 weight portion, Rhizoma disporopsis pernyi 15 weight portion, Radix seu Herba Spiranthis Lanceae 15 weight portion, Pericarpium Lagenariae sicerariae 17 weight portion, Semen Ziziphi Spinosae 23 weight portion, Poria 21 weight portion, Radix dioscoreae subcalvae 15 weight portion, Semen Firmianae 17 weight portion and Cortex Lycii 15 weight portion.
Described medicine also comprises: Tylorrhynchus heterochaeta Quatrefages, Semen Setariae italicae and Corm Eleocharitis.
Described medicine is made up of the raw medicinal material of following parts by weight: Herba Saxifragae 5-8 weight portion, Herba Scutellariae Barbatae 12-23 weight portion, Caulis Arcangelisiae 12-25 weight portion, Radix Stephaniae Japonicae 12-25 weight portion, Radix Et Rhizoma Fagopyri Tatarici 3-7 weight portion, Herba platantherae minoris 10-20 weight portion, Semen Benincasae 15-25 weight portion, Rhizoma disporopsis pernyi 12-18 weight portion, Radix seu Herba Spiranthis Lanceae 10-20 weight portion, Pericarpium Lagenariae sicerariae 12-20 weight portion, Semen Ziziphi Spinosae 17-28 weight portion, Poria 15-28 weight portion, Radix dioscoreae subcalvae 12-19 weight portion, Semen Firmianae 15-20 weight portion, Cortex Lycii 12-18 weight portion, Tylorrhynchus heterochaeta Quatrefages 17-30 weight portion, Semen Setariae italicae 12-18 weight portion and Corm Eleocharitis 13-25 weight portion.
Described medicine is made up of the raw medicinal material of following parts by weight: Herba Saxifragae 6 weight portion, Herba Scutellariae Barbatae 17 weight portion, Caulis Arcangelisiae 18 weight portion, Radix Stephaniae Japonicae 16 weight portion, Radix Et Rhizoma Fagopyri Tatarici 4 weight portion, Herba platantherae minoris 15 weight portion, Semen Benincasae 21 weight portion, Rhizoma disporopsis pernyi 15 weight portion, Radix seu Herba Spiranthis Lanceae 15 weight portion, Pericarpium Lagenariae sicerariae 17 weight portion, Semen Ziziphi Spinosae 23 weight portion, Poria 21 weight portion, Radix dioscoreae subcalvae 15 weight portion, Semen Firmianae 17 weight portion, Cortex Lycii 15 weight portion, Tylorrhynchus heterochaeta Quatrefages 23 weight portion, Semen Setariae italicae 15 weight portion and Corm Eleocharitis 19 weight portion.
In order to better realize foregoing invention object, present invention also offers a kind of medicine for the conditioning of lobar pneumonia convalescent period, the dosage form of described medicine is tablet, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.
The dosage form of described medicine is syrup, and its preparation method comprises the following steps:
The first step, Radix Stephaniae Japonicae, Radix Et Rhizoma Fagopyri Tatarici, Herba platantherae minoris, Semen Benincasae are mixed in proportion, be that the methanol of 70% ~ 80% is as solvent with determining alcohol, adopt percolation with the speed of 1 ~ 3ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, the quality of the methanol added is 3 ~ 5 times of first step mixture quality;
Second step, is mixed in proportion surplus stock medical material, is ground into powder;
3rd step, adds the distilled water of the powder quality 3 ~ 6 times obtained relative to second step, decocts 2 ~ 4 hours, filters, obtains the first filtrate; Filtering residue is added the distilled water relative to its quality 2 ~ 4 times, decoct 1 ~ 2 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 ~ 3/4 volume, add the ethanol that determining alcohol is 90 ~ 95%, make determining alcohol reach 70% ~ 80%, leave standstill 12 ~ 24 hours, filter, concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;
4th step, the powder mixing first step and the 3rd step obtained, add the distilled water relative to powder quality 3 ~ 5 times amount, the sucrose of 0.1 ~ 0.3 times, the sodium benzoate of 0.01 ~ 0.02 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.
The dosage form of described medicine is drop pill, and its preparation method comprises the following steps:
(1) take the mixing of all raw medicinal materials by weight, decoct with water 2 ~ 4 times, each 1 ~ 3 hour, add the water of 6 ~ 10 times amount, decoction liquor is filtered, and merges the filtrate of each time at every turn, concentrated, crushed after being dried, then add determining alcohol be 90% ~ 95% ethanol to alcohol content be 40% ~ 50%, leave standstill 3 ~ 5 hours, filter, filtrate is condensed into extractum, adds extractum 0.5-1 water doubly, leave standstill after stirring, filter, precipitate cold drying is also pulverized, and sieve acquisition mixed-powder;
(2) getting mixed-powder in step (1) puts in the substrate of 2-4 times amount melting, and mixing, in instillation coolant, obtains drop pill; Wherein, described substrate is one or more in sodium stearate, glycerin gelatine, stearic acid, glyceryl monostearate, hydrogenated vegetable oil or insect wax.
The invention has the beneficial effects as follows: medicine of the present invention with expelling remnant toxicity, QI invigorating lung moistening for primary treatment principle, hold concurrently with expectoration profit lung, damp eliminating spleen invigorating, help digestion stomach function regulating, the advantage conditioning lobar pneumonia convalescent patient, there is effective, instant effect, having no side effect and not easily recur.
Detailed description of the invention
The invention provides a kind of medicine for the conditioning of lobar pneumonia convalescent period, medicine comprises following raw medicinal material: Herba Saxifragae, Herba Scutellariae Barbatae, Caulis Arcangelisiae, Radix Stephaniae Japonicae, Radix Et Rhizoma Fagopyri Tatarici, Herba platantherae minoris, Semen Benincasae, Rhizoma disporopsis pernyi, Radix seu Herba Spiranthis Lanceae, Pericarpium Lagenariae sicerariae, Semen Ziziphi Spinosae, Poria, Radix dioscoreae subcalvae, Semen Firmianae and Cortex Lycii, and preferably medicine also comprises: Tylorrhynchus heterochaeta Quatrefages, Semen Setariae italicae and Corm Eleocharitis.
Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:
Herba Saxifragae: bitter, acrid, cold.Function cures mainly: heat-clearing and toxic substances removing.For fever of children, cough and asthma; Otitis media is controlled in external, and auricle festers, furuncle, furuncle and phyma, eczema.
Herba Scutellariae Barbatae: pungent, bitter, cold.Return lung, liver, kidney channel.Function cures mainly: heat-clearing and toxic substances removing, blood stasis dispelling diuresis.For furuncle swelling toxin, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, edema, jaundice.
Caulis Arcangelisiae: bitter, cold.Function cures mainly: clearing away heat-damp and promoting diuresis, removing toxic substances pain relieving.For preventing influenza, leptospirosis, control acute gastroenteritis, bacillary dysentery, tonsillitis, bronchitis, malaria; Eye conjunctivitis is controlled in external, skin eczema, impetigo, vaginitis.
Radix Stephaniae Japonicae: bitter, acrid, cold.Function cures mainly: heat-clearing and toxic substances removing, inducing diuresis to remove edema, wind-expelling pain-stopping.For laryngopharynx swelling and pain, toothache, stomachache, edema, beriberi, urgent micturition dysurea, dysuria, vulval eczema, rheumatic arthritis; Traumatic injury is controlled in external, venom, carbuncle furuncle.
Radix Et Rhizoma Fagopyri Tatarici: pungent, bitter, cool.Function cures mainly: heat-clearing and toxic substances removing, promoting blood circulation to remove blood stasis, invigorating spleen to remove dampness.For laryngopharynx swelling and pain, lung abscess, empyema, pneumonia, stomachache, hepatitis, dysentery, dyspepsia, night sweat, dysmenorrhea, amenorrhea, leucorrhea; Tuberculous lymphadenitis is controlled in external, carbuncle furuncle and phyma poison, traumatic injury.
Herba platantherae minoris: sweet is flat.Function cures mainly: nourishing YIN and moistening the lung, supplementing QI for promoting the production of body fluid.For cough with blood-flecked phlegm, laryngopharynx swelling and pain, weak after being ill, neurasthenia, seminal emission, dizzy.
Semen Benincasae: sweet, cold.Function cures mainly: lung heat clearing, reduce phlegm, evacuation of pus.Be applicable to the diseases such as cough due to lung-heat, lung abscess, acute appendicitis.
Rhizoma disporopsis pernyi: another name: the false cantonese fairy bells of bamboo root, Rhizoma Polygonati Odorati, Rhizoma Polygonati Odorati [Guizhou].Source: Liliaceae false Disporum Salisb plant bamboo root false cantonese fairy bells Disporopsis perryi (Hua) Diels, is used as medicine with root stock.Autumn and winter excavate, and clean and dry.Sweet, flat.Function cures mainly: nourishing YIN and moistening the lung, promoting the production of body fluid to quench thirst.Hyperhidrosis is coughed, xerostomia, puerperal asthenia for void.
Radix seu Herba Spiranthis Lanceae: sweet, light is flat.Function cures mainly: enriching yin boost qi, removing pathogenic heat from blood and toxic substance from the body.For body is empty after being ill, neurasthenia, hemoptysis of pulmonary tuberculosis, laryngopharynx swelling and pain, Infantile Summer Fever, diabetes, leucorrhea; Venom is controlled in external.
Pericarpium Lagenariae sicerariae: another name: gourd (" Book of Songs "), bottle gourd ("The Analects of Confucius"), kettle (《 Lu-Dian crest "), calabash courd (" Shuowen "), sweet a kind of edible gourd flesh (Tang Materia Medica), waist boat (《 Lu-Dian crest " land rent land note), a kind of edible gourd gourd (" the southern regions of the Yunnan Province book on Chinese herbal medicine ") aunt Kui (" florilegium "), bottle gourd (" book on Chinese herbal medicine asks former "), calabash (" decoction pieces is newly joined ").Source: be the fruit of cucurbitaceous plant lagenaria sicerariae.Take maturation and not old fruit autumn, peeling is used.Sweet in the mouth; Light; Property is put down.Return lung; Spleen; Kidney channel.Function cures mainly: diuretic; Detumescence; Logical woods; Eliminating stagnation.Main edema; Ascites; Jaundice; Quench one's thirst; Gonorrhea; Carbuncle.
Semen Ziziphi Spinosae: sweet, sour is flat.Return liver, gallbladder, heart channel.Function cures mainly: tonifying liver, mind calming, and arresting sweating promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.
Poria: sweet, light is flat.GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Radix dioscoreae subcalvae: sweet is flat.Function cures mainly: invigorating the spleen to clear away damp pathogen, invigorating the lung and the kidney.For pulmonary tuberculosis, diarrhea due to hypofunction of the spleen, quenches one's thirst; Traumatic injury is controlled in external.
Semen Firmianae: sweet in the mouth; Property is put down.GUIXIN; Lung; Stomach warp.Function cures mainly: pleasant stomach function regulating; Strengthening the spleen to promote digestion; Hemostasis.Main gastralgia; To get ill from overeating diarrhoea; Hernia; Early whitening of beard and hair; Oral aphthae in children.
Cortex Lycii: sweet, cold.Return lung, liver, kidney channel.Function cures mainly: removing heat from blood removes and steams, lung heat clearing pathogenic fire reducing.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat, spitting of blood, epistaxis, interior-heat is quenched one's thirst.
Tylorrhynchus heterochaeta Quatrefages: sweet in the mouth; Warm in nature.Return spleen; Stomach warp.Function cures mainly: tonifying the spleen and stomach; Replenishing QI and blood; Inducing diuresis to remove edema.Main weakness of the spleen and stomach; Have loose bowels; Anemia; Edema.
Semen Setariae italicae: light; Be slightly cold.Return large intestine; Spleen; Kidney; Urinary bladder channel.Function cures mainly: eliminating damp-heat.Main edema; Dysuria; Vexed; Thirsty; Dysentery; Eczema; Furuncle.
Corm Eleocharitis: sweet in the mouth; Cold in nature.Return lung; Stomach warp.Function cures mainly: clearing away heat and promoting production of body fluid; Reduce phlegm; Removing food stagnancy.Main epidemic febrile disease is thirsty; Laryngopharynx swelling and pain; Phlegm-heat cough; Conjunctival congestion; Quench one's thirst; Dysentery; Jaundice; Pyretic stranguria; Food stagnation; Wart.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
Embodiment 1 tablet
Embodiments provide a kind of medicine for the conditioning of lobar pneumonia convalescent period, be made up of the raw medicinal material of following parts by weight: Herba Saxifragae 6 weight portion, Herba Scutellariae Barbatae 17 weight portion, Caulis Arcangelisiae 18 weight portion, Radix Stephaniae Japonicae 16 weight portion, Radix Et Rhizoma Fagopyri Tatarici 4 weight portion, Herba platantherae minoris 15 weight portion, Semen Benincasae 21 weight portion, Rhizoma disporopsis pernyi 15 weight portion, Radix seu Herba Spiranthis Lanceae 15 weight portion, Pericarpium Lagenariae sicerariae 17 weight portion, Semen Ziziphi Spinosae 23 weight portion, Poria 21 weight portion, Radix dioscoreae subcalvae 15 weight portion, Semen Firmianae 17 weight portion and Cortex Lycii 15 weight portion;
Its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 90%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1.5 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1.5 hours, pulverize, sieve, obtain 300 object micropowders;
3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.2 times, 0.1 times of lactose, the starch of 0.2 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.03 times of magnesium stearate, granulate, tabletting, makes.
Embodiment 2 syrup
Embodiments provide a kind of medicine for the conditioning of lobar pneumonia convalescent period, be made up of the raw medicinal material of following parts by weight: Herba Saxifragae 6 weight portion, Herba Scutellariae Barbatae 17 weight portion, Caulis Arcangelisiae 18 weight portion, Radix Stephaniae Japonicae 16 weight portion, Radix Et Rhizoma Fagopyri Tatarici 4 weight portion, Herba platantherae minoris 15 weight portion, Semen Benincasae 21 weight portion, Rhizoma disporopsis pernyi 15 weight portion, Radix seu Herba Spiranthis Lanceae 15 weight portion, Pericarpium Lagenariae sicerariae 17 weight portion, Semen Ziziphi Spinosae 23 weight portion, Poria 21 weight portion, Radix dioscoreae subcalvae 15 weight portion, Semen Firmianae 17 weight portion, Cortex Lycii 15 weight portion, Tylorrhynchus heterochaeta Quatrefages 23 weight portion, Semen Setariae italicae 15 weight portion and Corm Eleocharitis 19 weight portion.
Its preparation method comprises the following steps:
The first step, Radix Stephaniae Japonicae, Radix Et Rhizoma Fagopyri Tatarici, Herba platantherae minoris, Semen Benincasae are mixed in proportion, be that the methanol of 75% is as solvent with determining alcohol, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, the quality of the methanol added is 4 times of first step mixture quality;
Second step, is mixed in proportion surplus stock medical material, is ground into powder;
3rd step, adds the distilled water of the powder quality 5 times obtained relative to second step, decocts 3 hours, filters, obtains the first filtrate; Filtering residue is added the distilled water relative to its quality 3 times, decoct 1.5 hours, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 3/4 volume, add the ethanol that determining alcohol is 90%, make determining alcohol reach 75%, leave standstill 18 hours, filter, concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;
4th step, the powder mixing first step and the 3rd step obtained, add the distilled water relative to powder quality 4 times amount, the sucrose of 0.2 times, the sodium benzoate of 0.02 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.
Embodiment 3 drop pill
Embodiments provide a kind of medicine for the conditioning of lobar pneumonia convalescent period, be made up of the raw medicinal material of following parts by weight: Herba Saxifragae 28 weight portion, Herba Scutellariae Barbatae 23 weight portion, Caulis Arcangelisiae 25 weight portion, Radix Stephaniae Japonicae 12 weight portion, Radix Et Rhizoma Fagopyri Tatarici 3 weight portion, Herba platantherae minoris 10 weight portion, Semen Benincasae 25 weight portion, Rhizoma disporopsis pernyi 18 weight portion, Radix seu Herba Spiranthis Lanceae 10 weight portion, Pericarpium Lagenariae sicerariae 12 weight portion, Semen Ziziphi Spinosae 28 weight portion, Poria 15 weight portion, Radix dioscoreae subcalvae 12 weight portion, Semen Firmianae 20 weight portion, Cortex Lycii 12 weight portion, Tylorrhynchus heterochaeta Quatrefages 30 weight portion, Semen Setariae italicae 18 weight portion and Corm Eleocharitis 25 weight portion,
Its preparation method comprises the following steps:
(1) take the mixing of all raw medicinal materials by weight, decoct with water 3 times, each 2 hours, add the water of 8 times amount, decoction liquor is filtered, and merges the filtrate of each time at every turn, concentrated, crushed after being dried, then add determining alcohol be 90% ethanol to alcohol content be 45%, leave standstill 4 hours, filter, filtrate is condensed into extractum, adds the water of extractum 0.8 times, leave standstill after stirring, filter, precipitate cold drying is also pulverized, and sieve acquisition mixed-powder;
(2) getting mixed-powder in step (1) puts in the substrate of 3 times amount meltings, and mixing, in instillation coolant, obtains drop pill; Wherein, substrate is sodium stearate, glycerin gelatine, stearic acid, glyceryl monostearate, hydrogenated vegetable oil and insect wax.
Toxicity test
Application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 22g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The tablet dissolved prepared by embodiments of the invention 1 is in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 32.9 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>32.9 crude drug/kg of the present invention, every day, maximum dosage-feeding was 65.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 4.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.073g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 20g) oral administration gavage Chinese medicine of the present invention is 901 times of quantity.Therefore Chinese drug anesthesia medicine acute toxicity of the present invention is low, clinical drug safety.
The syrup of the embodiment of the present invention 2 is pressed 7.81,18.34 and 40.11g crude drug/kg continuous use 12 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 12 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Select 20 healthy mices, female, each 10 of hero, with the drop pill of the embodiment of the present invention 3 for object, dose design is first phase in every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, the LD 50 that is female, male mice of this sample be 5000m part/k part BW (five dosage is 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjustment dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose to tested material after 20 days, female, buck all occurs without death condition.
Clinical trial
Case selection: during selecting in May ,-2014 in May, 2012, derive from the court 350 example and be in the convalescent patient of lobar pneumonia, man 220 example, female 60 example, age 27-45 year, at random 350 routine patients are divided into four groups at random, often organize 70 examples, be respectively embodiment group 1-3, matched group and blank group, each group patient all without significant difference, has statistical significance in sex, age, the state of an illness etc.Above-mentioned patient is all diagnosed as lobar pneumonia, and after identical Therapeutic Method, symptom takes a turn for the better to some extent, but it is on the cycle of recovery, Relapse rate shows effect, and occurs that pathogenic heat in various degree go down, and remaining heresy is not to the greatest extent, because it is hot for a long time, consumption of YIN-fluid, is shown in low grade fever, xerostomia by disease, time have dry cough night sweat, anorexia, red tongue tongue are few, thready pulse.
Therapeutic Method:
Embodiment group 1: the tablet using the embodiment of the present invention 1, every day twice, each two panels, uses 10-30 days continuously;
Embodiment group 2: the syrup using the embodiment of the present invention 2, every day twice, each 10ml, uses 10-30 days continuously;
Embodiment group 3: the drop pill using the embodiment of the present invention 3, every day twice, each 10, uses 10-30 days continuously;
Matched group: continue to use antibiotic to treat, traditionally Therapeutic Method is treated, and uses 10-30 days continuously;
Blank group: inapplicable any medicine.
Criterion of therapeutical effect: recovery from illness: nurse one's health in 30 days, the state of an illness is not shown effect, and symptom disappears completely, and diet, sleep, muscle power etc. all recover normal; Effective: nurse one's health in 30 days, though the state of an illness has outbreak sign, symptom disappears very soon, diet, sleep, muscle power etc. recover normal substantially; Invalid: nurse one's health in 30 days, symptom does not change substantially, and the state of an illness is recurrent exerbation still, diet, sleep, muscle power etc. are recovered substantially do not change or change not obvious.
Therapeutic outcome:
See table 1 and table 2, as can be seen from Table 1, adopt medicine of the present invention for the conditioning of lobar pneumonia reconvalescent, relative to traditional remedies on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt medicine of the present invention for the conditioning of lobar pneumonia reconvalescent, relative to traditional remedies, treatment the course for the treatment of on significantly shorten.
Clinical efficacy comparison example after 10-30 days treated respectively by table 1 respectively group
Table 2 respectively organizes treatment 10-30 days rear healing numbers and the time comparative example (%) of recovery from illness patient
According to the clinical statistics in above table, medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, the advantage that has no side effect; Cure follow-up of patients's half a year to each group, result is added up simultaneously, 57 examples of embodiment group 1, and 1 example obtains lobar pneumonia again, and relapse rate is 1.8%; 65 examples of embodiment group 2,0 example obtains lobar pneumonia again, and relapse rate is 0%; 62 examples of embodiment group 3,1 example obtains lobar pneumonia again, and relapse rate is 1.6%; 29 examples of matched group, 4 examples obtain lobar pneumonia again, and relapse rate is 13.8%; 19 examples of blank group, 9 examples obtain lobar pneumonia again, and relapse rate is 47.4%.
Model case
In January, 2014, grandson, man, 28 years old, there is common cold history, because of unexpected onset shiver with cold, high heat, companion's cough, chest pain, rapid breathing, rusty expectoration is gone to a doctor, and finds that thorax is symmetrical, the respiratory movement of sick side weakens on inspection, trachea is placed in the middle, sick side vocal fremitus strengthens, and diseased region percussion is voiced sound, diseased region audible and bronchial breathing sound and loud moist rales, voice resonant check, the pulmonary consolidation sign such as person's audible and pleuritic rub of involving pleura.Blood leukocytes sum increases, and neutrophilic granulocyte reaches more than 0.80, shift to left, has toxic granulation.The visible a large amount of gram-positive cocci of Sputum smears.Expectorant, hemoculture have streptococcus pneumoniae to grow.The large lamellar increase in density shade of chest X-ray display leaf uniformity.Blood gas analysis inspection has PaO2 and PaCO2 to decline, be diagnosed as lobar pneumonia, through treatment, now temperature decline, audible moist rale again, pulmonary consolidation sign disappears, and diseased region hatching density is decrescence low, and bright degree is cumulative to be added, but often there is low grade fever, xerostomia, time have dry cough night sweat, anorexia, red tongue tongue are few, the phenomenon of thready pulse, on the cycle of recovery after diagnosing, the syrup of the embodiment of the present invention 2 is used to treat, every day twice, each 10ml, continuous use 12 days, period, the state of an illness was not shown effect, and symptom disappears completely, and diet, sleep, muscle power etc. all recover normal.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. for the medicine of lobar pneumonia convalescent period conditioning, it is characterized in that, described medicine comprises following raw medicinal material: Herba Saxifragae, Herba Scutellariae Barbatae, Caulis Arcangelisiae, Radix Stephaniae Japonicae, Radix Et Rhizoma Fagopyri Tatarici, Herba platantherae minoris, Semen Benincasae, Rhizoma disporopsis pernyi, Radix seu Herba Spiranthis Lanceae, Pericarpium Lagenariae sicerariae, Semen Ziziphi Spinosae, Poria, Radix dioscoreae subcalvae, Semen Firmianae and Cortex Lycii.
2. the medicine for the conditioning of lobar pneumonia convalescent period according to claim 1, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Herba Saxifragae 5-8 weight portion, Herba Scutellariae Barbatae 12-23 weight portion, Caulis Arcangelisiae 12-25 weight portion, Radix Stephaniae Japonicae 12-25 weight portion, Radix Et Rhizoma Fagopyri Tatarici 3-7 weight portion, Herba platantherae minoris 10-20 weight portion, Semen Benincasae 15-25 weight portion, Rhizoma disporopsis pernyi 12-18 weight portion, Radix seu Herba Spiranthis Lanceae 10-20 weight portion, Pericarpium Lagenariae sicerariae 12-20 weight portion, Semen Ziziphi Spinosae 17-28 weight portion, Poria 15-28 weight portion, Radix dioscoreae subcalvae 12-19 weight portion, Semen Firmianae 15-20 weight portion and Cortex Lycii 12-18 weight portion.
3. the medicine for the conditioning of lobar pneumonia convalescent period according to claim 1 and 2, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Herba Saxifragae 6 weight portion, Herba Scutellariae Barbatae 17 weight portion, Caulis Arcangelisiae 18 weight portion, Radix Stephaniae Japonicae 16 weight portion, Radix Et Rhizoma Fagopyri Tatarici 4 weight portion, Herba platantherae minoris 15 weight portion, Semen Benincasae 21 weight portion, Rhizoma disporopsis pernyi 15 weight portion, Radix seu Herba Spiranthis Lanceae 15 weight portion, Pericarpium Lagenariae sicerariae 17 weight portion, Semen Ziziphi Spinosae 23 weight portion, Poria 21 weight portion, Radix dioscoreae subcalvae 15 weight portion, Semen Firmianae 17 weight portion and Cortex Lycii 15 weight portion.
4. the medicine for the conditioning of lobar pneumonia convalescent period according to any one of claim 1-3, it is characterized in that, described medicine also comprises: Tylorrhynchus heterochaeta Quatrefages, Semen Setariae italicae and Corm Eleocharitis.
5. the medicine for the conditioning of lobar pneumonia convalescent period according to any one of claim 1-4, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Herba Saxifragae 5-8 weight portion, Herba Scutellariae Barbatae 12-23 weight portion, Caulis Arcangelisiae 12-25 weight portion, Radix Stephaniae Japonicae 12-25 weight portion, Radix Et Rhizoma Fagopyri Tatarici 3-7 weight portion, Herba platantherae minoris 10-20 weight portion, Semen Benincasae 15-25 weight portion, Rhizoma disporopsis pernyi 12-18 weight portion, Radix seu Herba Spiranthis Lanceae 10-20 weight portion, Pericarpium Lagenariae sicerariae 12-20 weight portion, Semen Ziziphi Spinosae 17-28 weight portion, Poria 15-28 weight portion, Radix dioscoreae subcalvae 12-19 weight portion, Semen Firmianae 15-20 weight portion, Cortex Lycii 12-18 weight portion, Tylorrhynchus heterochaeta Quatrefages 17-30 weight portion, Semen Setariae italicae 12-18 weight portion and Corm Eleocharitis 13-25 weight portion.
6. the medicine for the conditioning of lobar pneumonia convalescent period according to any one of claim 1-5, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Herba Saxifragae 6 weight portion, Herba Scutellariae Barbatae 17 weight portion, Caulis Arcangelisiae 18 weight portion, Radix Stephaniae Japonicae 16 weight portion, Radix Et Rhizoma Fagopyri Tatarici 4 weight portion, Herba platantherae minoris 15 weight portion, Semen Benincasae 21 weight portion, Rhizoma disporopsis pernyi 15 weight portion, Radix seu Herba Spiranthis Lanceae 15 weight portion, Pericarpium Lagenariae sicerariae 17 weight portion, Semen Ziziphi Spinosae 23 weight portion, Poria 21 weight portion, Radix dioscoreae subcalvae 15 weight portion, Semen Firmianae 17 weight portion, Cortex Lycii 15 weight portion, Tylorrhynchus heterochaeta Quatrefages 23 weight portion, Semen Setariae italicae 15 weight portion and Corm Eleocharitis 19 weight portion.
7. the medicine for the conditioning of lobar pneumonia convalescent period according to any one of claim 1-6, it is characterized in that, the dosage form of described medicine is tablet, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.
8. the medicine for the conditioning of lobar pneumonia convalescent period according to any one of claim 1-6, it is characterized in that, the dosage form of described medicine is syrup, and its preparation method comprises the following steps:
The first step, Radix Stephaniae Japonicae, Radix Et Rhizoma Fagopyri Tatarici, Herba platantherae minoris, Semen Benincasae are mixed in proportion, be that the methanol of 70% ~ 80% is as solvent with determining alcohol, adopt percolation with the speed of 1 ~ 3ml per minute slowly percolation, collect percolate, concentrating under reduced pressure is also dry, obtains and gets dry extract, be ground into powder, the quality of the methanol added is 3 ~ 5 times of first step mixture quality;
Second step, is mixed in proportion surplus stock medical material, is ground into powder;
3rd step, adds the distilled water of the powder quality 3 ~ 6 times obtained relative to second step, decocts 2 ~ 4 hours, filters, obtains the first filtrate; Filtering residue is added the distilled water relative to its quality 2 ~ 4 times, decoct 1 ~ 2 hour, filter, obtain the second filtrate; Merge the first filtrate and the second filtrate, concentrate away the water of 2/3 ~ 3/4 volume, add the ethanol that determining alcohol is 90 ~ 95%, make determining alcohol reach 70% ~ 80%, leave standstill 12 ~ 24 hours, filter, concentrating under reduced pressure, dry, obtain and get dry extract, be ground into powder;
4th step, the powder mixing first step and the 3rd step obtained, add the distilled water relative to powder quality 3 ~ 5 times amount, the sucrose of 0.1 ~ 0.3 times, the sodium benzoate of 0.01 ~ 0.02 times, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.
9. the medicine for the conditioning of lobar pneumonia convalescent period according to any one of claim 1-5, it is characterized in that, the dosage form of described medicine is drop pill, and its preparation method comprises the following steps:
(1) take the mixing of all raw medicinal materials by weight, decoct with water 2 ~ 4 times, each 1 ~ 3 hour, add the water of 6 ~ 10 times amount, decoction liquor is filtered, and merges the filtrate of each time at every turn, concentrated, crushed after being dried, then add determining alcohol be 90% ~ 95% ethanol to alcohol content be 40% ~ 50%, leave standstill 3 ~ 5 hours, filter, filtrate is condensed into extractum, adds extractum 0.5-1 water doubly, leave standstill after stirring, filter, precipitate cold drying is also pulverized, and sieve acquisition mixed-powder;
(2) getting mixed-powder in step (1) puts in the substrate of 2-4 times amount melting, and mixing, in instillation coolant, obtains drop pill.
10. the medicine for the conditioning of lobar pneumonia convalescent period according to claim 9, it is characterized in that, the substrate in described step (2) is one or more in sodium stearate, glycerin gelatine, stearic acid, glyceryl monostearate, hydrogenated vegetable oil or insect wax.
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