CN104474399A - Pharmaceutical preparation for treating spurs caused by blood stasis - Google Patents
Pharmaceutical preparation for treating spurs caused by blood stasis Download PDFInfo
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- CN104474399A CN104474399A CN201410716337.2A CN201410716337A CN104474399A CN 104474399 A CN104474399 A CN 104474399A CN 201410716337 A CN201410716337 A CN 201410716337A CN 104474399 A CN104474399 A CN 104474399A
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Abstract
The invention discloses a pharmaceutical preparation for treating spurs caused by blood stasis and a preparation method thereof, wherein the pharmaceutical preparation comprises the following medicinal raw materials: largeflower triplostegia roots, smilax riparia, acanthopanax, Dendropanax trifidus Mak, elsholtzia patrini garcke, jasminum giraldii diels, toricellia angulata, smilacina japonica, flos carthami, david anemone, helicia cochinchinensis, concha arcae, Euonymus carnosus Hemsl., fructus livistonae chinensis, gaultheria, laciniate blumea herb, smilax stans, berba aristolochiae mollissimae, loose knots, sealwort, rhizoma cibotii, evening primrose, false spiraea, Tieluohan, potanin larkspur roots and pepper. The pharmaceutical preparation disclosed by the invention has the beneficial effects that the pharmaceutical preparation based on the treatment principle of promoting blood circulation and tonifying qi, removing blood stasis and dispersing phlegm, eliminating cold to stop pain and strengthening tendons and bones is mainly used for treating spurs caused by blood stasis; the pharmaceutical preparation is simple and convenient in preparation process, small in toxic and side effects, convenient to administrate, easy to prepare and low in cost; and the pharmaceutical preparation can directly reach the focus, is short in cure time, and spurs are difficult to replase after healing.
Description
Technical field
The present invention relates to pharmaceutical technology, particularly a kind of pharmaceutical preparation and preparation method for the treatment of type of stagnation of blood stasis bony spur.
Background technology
Bony spur is wearing and tearing, the destruction that cartilage is caused in joint because of various reasons, and facilitates the reparation of sclerotin itself, sclerosis and hypertrophy, is a kind of naturally catabiosis.But bony spur is not the proprietary disease of old man, because work kenel changes, many people must sitting, stand for a long time, add fault, being easy to the age just makes vertebra ahead of time degradation phenomena occur gently, and brings out the generation of bony spur.
Bony spur, can betide different parts in health skeleton, and especially spinal bone, calcaneus and joint part are common, and motherland's medical science is referred to as " osteophytosis ".Sporadically appear in the disease such as " arthromyodynia ", " neck and shoulder pain ", " neck muscular contracture ", " phlegm syndrome ", " headache ", " dizzy ", " stiffness of the nape ", " calcaneodynia ".
The method of Modern medical therapy bony spur mainly contains operative treatment, massage and traction and western medicine.
Operative treatment: operative treatment is not the first-selected therapy of hyperosteogeny.When select expectant treatment invalid and the state of an illness heavier, have a strong impact on minimal invasive treatment time, can operative treatment be considered.
Massage and traction are applicable to neck, lumbar hyperosteogency, coxarthrosis.Massage and the effect of the complete outer power of traction, only integrally regulating in human body locally treating but to ignore, therefore, can only play temporary transient analgesic effect, and can not reach the object for the treatment of.
Western medicine: numerous to health side effect, and curative effect is of short duration, need take continuously.
Bony spur TCM syndrome typing
(1) marrow of suffering from a deficiency of the kidney loses: joint has a dull ache, soreness of the waist and knees, and waist lower limb is unfavorable, and pitching is changed one's position unfavorable.With dizziness, tinnitus, deaf, dizzy.Light red tongue, white and thin fur, thready pulse.
(2) stagnation of blood stasis: limbs joint pain, heavily work, joint stuffiness, Changes in weather increases the weight of, and light night in daytime is heavy, pain increase in intensity under coldness, obtains hotly slightly to subtract.Light red tongue, tongue is white, and deep-thready pulse delays.
(3) stagnation of blood stasis: joint sting, sore spot is fixed, joint deformity, movable unfavorable, or the curved back of the body camel of waist, dim complexion.Words are purple dark, deep pulse or carefully puckery.
(4) phlegm-damp becomes silted up and hinders: the heavy swelling and pain of limbs joint, notably arthroncus, severe one is not moved, extremity inconvenient activity.Pale tongue, tongue is greasy in vain, and moderate pulse moistens.
Western medical treatment bony spur is undesirable, just takes stopgap measures and does not effect a permanent cure, and the state of an illness easily recurs, and cost height patient is difficult to accept.
Treatment by Chinese herbs bony spur is than the maximum advantage of Western medicine, effects a radical cure from pathology.Can the stress of obvious reduction of patient; Cost price is low, and route of administration is convenient, and patient is easy to accept, and has the value potentiality that clinical market is promoted.
The present invention has QI invigorating of invigorating blood circulation, blood stasis-eliminating and stagnation-dissipating, dispersing cold for relieving pain, and bone and muscle strengthening is Therapeutic Principle, cures mainly type of stagnation of blood stasis bony spur; And processing technology is easy, the little and convenient drug administration of toxic and side effects, medicament is easy to manufacture, and pharmaceutical preparation with low cost, focus of going directly, healing time is short, not easily recurs after healing.
Summary of the invention
The technical problem to be solved in the present invention there are provided one and has QI invigorating of invigorating blood circulation, blood stasis-eliminating and stagnation-dissipating, dispersing cold for relieving pain, bone and muscle strengthening effect, cures mainly the medicine of type of stagnation of blood stasis bony spur; Formula is simple, processing technology is easy, the little and convenient drug administration of toxic and side effects, and medicament is easy to manufacture, new drug with low cost.The present invention is pharmaceutical preparation, but the Chinese medicine that selected abnormal smells from the patient is gentle, makes the abnormal smells from the patient of pharmaceutical preparation and light.The present invention adopts the Chinese crude drug of different properties, has carried out scientific compatibility, can reach desirable therapeutic effect, and safety, toxic and side effects is little, and preparation is simple, and focus of going directly, healing time is short, not easily recurs after healing.
For solving the problems of the technologies described above; the invention provides a kind of pharmaceutical preparation for the treatment of type of stagnation of blood stasis bony spur; pharmaceutical preparation is made up of endo-medicine and external used medicine, and described endo-medicine comprises following raw medicinal material: Radix Triplostegiae Grandiflorae, Radix et Rhizoma Smilacis Ripariae, Radix Et Caulis Acanthopanacis Senticosi, Radix polygalae arillatae, Herba Origani, Radix Jasmini Giraldii, Radix seu folium Gaultheriae intermediae, Radix et rhizoma smilacinae japonicae, Flos Carthami, Rhizoma anemones davidii, Radix seu Folium Heliciae cochinchinensis, Concha Arcae, expectorant medicine, Chinese fanpalm seed, Gaultheria, the Herba Blumeae Laciniatae, Rhizoma et radix smilacis santis, Herba Aristolochiae Mollissimae, Lignum Pini Nodi, Rhizoma Polygonati, Rhizoma Cibotii and Radix Oenotherae erythrosepalae; External used medicine comprises following raw medicinal material: Radix Triplostegiae Grandiflorae, Radix Et Caulis Acanthopanacis Senticosi, Radix polygalae arillatae, Herba Origani, Radix seu folium Gaultheriae intermediae, Radix et rhizoma smilacinae japonicae, Flos Carthami, Rhizoma anemones davidii, Radix seu Folium Heliciae cochinchinensis, Concha Arcae, expectorant medicine, Chinese fanpalm seed, Gaultheria, the Herba Blumeae Laciniatae, Rhizoma et radix smilacis santis, Herba Aristolochiae Mollissimae, Lignum Pini Nodi, Rhizoma Polygonati, Rhizoma Cibotii, Radix Oenotherae erythrosepalae, Cortex Sorbariae Arboreae, The Iron Buddha, Radix delphinii fargesii and Pericarpium Zanthoxyli.
In described endo-medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Triplostegiae Grandiflorae 25-46 part, Radix et Rhizoma Smilacis Ripariae 13-25 part, Radix Et Caulis Acanthopanacis Senticosi 26-42 part, Radix polygalae arillatae 22-38 part, Herba Origani 14-27 part, Radix Jasmini Giraldii 13-24 part, Radix seu folium Gaultheriae intermediae 27-39 part, Radix et rhizoma smilacinae japonicae 14-28 part, Flos Carthami 16-29 part, Rhizoma anemones davidii 9-16 part, Radix seu Folium Heliciae cochinchinensis 11-25 part, Concha Arcae 10-19 part, expectorant medicine 13-24 part, Chinese fanpalm seed 6-14 part, Gaultheria 22-35 part, Herba Blumeae Laciniatae 23-34 part, Rhizoma et radix smilacis santis 11-20 part, Herba Aristolochiae Mollissimae 6-14 part, Lignum Pini Nodi 6-14 part, Rhizoma Polygonati 11-20 part, Rhizoma Cibotii 20-30 part and Radix Oenotherae erythrosepalae 19-28 part, in external used medicine, the ratio of weight and number of each raw medicinal material can be preferably: Radix Triplostegiae Grandiflorae 25-41 part, Radix Et Caulis Acanthopanacis Senticosi 20-35 part, Radix polygalae arillatae 22-35 part, Herba Origani 14-27 part, Radix seu folium Gaultheriae intermediae 27-39 part, Radix et rhizoma smilacinae japonicae 14-28 part, Flos Carthami 16-29 part, Rhizoma anemones davidii 9-16 part, Radix seu Folium Heliciae cochinchinensis 11-25 part, Concha Arcae 10-19 part, expectorant medicine 13-24 part, Chinese fanpalm seed 6-14 part, Gaultheria 22-38 part, Herba Blumeae Laciniatae 26-39 part, Rhizoma et radix smilacis santis 16-24 part, Herba Aristolochiae Mollissimae 14-24 part, Lignum Pini Nodi 9-19 part, Rhizoma Polygonati 11-20 part, Rhizoma Cibotii 20-30 part, Radix Oenotherae erythrosepalae 19-28 part, Cortex Sorbariae Arboreae 4-9 part, The Iron Buddha 4-9 part, Radix delphinii fargesii 3-8 part and Pericarpium Zanthoxyli 3-8 part.
In described endo-medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Radix Triplostegiae Grandiflorae 26-44 part, Radix et Rhizoma Smilacis Ripariae 15-23 part, Radix Et Caulis Acanthopanacis Senticosi 26-40 part, Radix polygalae arillatae 23-36 part, Herba Origani 16-25 part, Radix Jasmini Giraldii 15-22 part, Radix seu folium Gaultheriae intermediae 27-34 part, Radix et rhizoma smilacinae japonicae 15-26 part, Flos Carthami 18-27 part, Rhizoma anemones davidii 10-15 part, Radix seu Folium Heliciae cochinchinensis 12-23 part, Concha Arcae 12-17 part, expectorant medicine 14-23 part, Chinese fanpalm seed 7-12 part, Gaultheria 23-33 part, Herba Blumeae Laciniatae 24-32 part, Rhizoma et radix smilacis santis 13-19 part, Herba Aristolochiae Mollissimae 8-12 part, Lignum Pini Nodi 6-11 part, Rhizoma Polygonati 14-18 part, Rhizoma Cibotii 23-28 part and Radix Oenotherae erythrosepalae 19-24 part, in external used medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Radix Triplostegiae Grandiflorae 27-40 part, Radix Et Caulis Acanthopanacis Senticosi 21-33 part, Radix polygalae arillatae 24-32 part, Herba Origani 16-25 part, Radix seu folium Gaultheriae intermediae 28-37 part, Radix et rhizoma smilacinae japonicae 15-26 part, Flos Carthami 18-27 part, Rhizoma anemones davidii 10-15 part, Radix seu Folium Heliciae cochinchinensis 12-23 part, 12-17 part, expectorant medicine 14-23 part, Chinese fanpalm seed 7-12 part, Gaultheria 23-33 part, Herba Blumeae Laciniatae 27-36 part, Rhizoma et radix smilacis santis 18-22 part, Herba Aristolochiae Mollissimae 15-21 part, Lignum Pini Nodi 10-17 part, Rhizoma Polygonati 13-17 part, Rhizoma Cibotii 23-28 part, Radix Oenotherae erythrosepalae 19-23 part, Cortex Sorbariae Arboreae 4-8 part, The Iron Buddha 4-8 part, Radix delphinii fargesii 3-7 part and Pericarpium Zanthoxyli 3-7 part.
In described endo-medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Radix Triplostegiae Grandiflorae 26 parts, Radix et Rhizoma Smilacis Ripariae 21 parts, Radix Et Caulis Acanthopanacis Senticosi 34 parts, Radix polygalae arillatae 36 parts, Herba Origani 16 parts, Radix Jasmini Giraldii 17 parts, Radix seu folium Gaultheriae intermediae 31 parts, Radix et rhizoma smilacinae japonicae 22 parts, 18 parts, Flos Carthami, Rhizoma anemones davidii 12 parts, Radix seu Folium Heliciae cochinchinensis 17 parts, Concha Arcae 15 parts, expectorant medicine 19 parts, Chinese fanpalm seed 7 parts, Gaultheria 31 parts, the Herba Blumeae Laciniatae 24 parts, Rhizoma et radix smilacis santis 16 parts, Herba Aristolochiae Mollissimae 8 parts, Lignum Pini Nodi 7 parts, Rhizoma Polygonati 14 parts, Rhizoma Cibotii 26 parts and Radix Oenotherae erythrosepalae 19 parts, in external used medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Radix Triplostegiae Grandiflorae 38 parts, Radix Et Caulis Acanthopanacis Senticosi 21 parts, Radix polygalae arillatae 28 parts, Herba Origani 16 parts, Radix seu folium Gaultheriae intermediae 35 parts, Radix et rhizoma smilacinae japonicae 15 parts, 25 parts, Flos Carthami, Rhizoma anemones davidii 10 parts, Radix seu Folium Heliciae cochinchinensis 21 parts, Concha Arcae 15 parts, expectorant medicine 14 parts, Chinese fanpalm seed 12 parts, Gaultheria 32 parts, the Herba Blumeae Laciniatae 31 parts, Rhizoma et radix smilacis santis 18 parts, Herba Aristolochiae Mollissimae 17 parts, Lignum Pini Nodi 10 parts, Rhizoma Polygonati 15 parts, Rhizoma Cibotii 23 parts, Radix Oenotherae erythrosepalae 21 parts, Cortex Sorbariae Arboreae 4 parts, The Iron Buddha 8 parts, Radix delphinii fargesii 3 parts and 5 parts, Pericarpium Zanthoxyli.
In described endo-medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Radix Triplostegiae Grandiflorae 44 parts, Radix et Rhizoma Smilacis Ripariae 23 parts, Radix Et Caulis Acanthopanacis Senticosi 26 parts, Radix polygalae arillatae 29 parts, Herba Origani 25 parts, Radix Jasmini Giraldii 22 parts, Radix seu folium Gaultheriae intermediae 27 parts, Radix et rhizoma smilacinae japonicae 26 parts, 27 parts, Flos Carthami, Rhizoma anemones davidii 15 parts, Radix seu Folium Heliciae cochinchinensis 12 parts, Concha Arcae 17 parts, expectorant medicine 23 parts, Chinese fanpalm seed 12 parts, Gaultheria 33 parts, the Herba Blumeae Laciniatae 32 parts, Rhizoma et radix smilacis santis 19 parts, Herba Aristolochiae Mollissimae 12 parts, Lignum Pini Nodi 11 parts, Rhizoma Polygonati 18 parts, Rhizoma Cibotii 28 parts and Radix Oenotherae erythrosepalae 24 parts, in external used medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Radix Triplostegiae Grandiflorae 40 parts, Radix Et Caulis Acanthopanacis Senticosi 33 parts, Radix polygalae arillatae 32 parts, Herba Origani 25 parts, Radix seu folium Gaultheriae intermediae 37 parts, Radix et rhizoma smilacinae japonicae 26 parts, 27 parts, Flos Carthami, Rhizoma anemones davidii 15 parts, Radix seu Folium Heliciae cochinchinensis 23 parts, Concha Arcae 17 parts, expectorant medicine 23 parts, Chinese fanpalm seed 7 parts, Gaultheria 23 parts, the Herba Blumeae Laciniatae 36 parts, Rhizoma et radix smilacis santis 22 parts, Herba Aristolochiae Mollissimae 21 parts, Lignum Pini Nodi 17 parts, Rhizoma Polygonati 17 parts, Rhizoma Cibotii 26 parts, Radix Oenotherae erythrosepalae 23 parts, Cortex Sorbariae Arboreae 8 parts, The Iron Buddha 6 parts, Radix delphinii fargesii 5 parts and 7 parts, Pericarpium Zanthoxyli.
In described endo-medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Radix Triplostegiae Grandiflorae 35 parts, Radix et Rhizoma Smilacis Ripariae 15 parts, Radix Et Caulis Acanthopanacis Senticosi 40 parts, Radix polygalae arillatae 23 parts, Herba Origani 21 parts, Radix Jasmini Giraldii 15 parts, Radix seu folium Gaultheriae intermediae 34 parts, Radix et rhizoma smilacinae japonicae 15 parts, 24 parts, Flos Carthami, Rhizoma anemones davidii 10 parts, Radix seu Folium Heliciae cochinchinensis 23 parts, Concha Arcae 12 parts, expectorant medicine 14 parts, Chinese fanpalm seed 11 parts, Gaultheria 23 parts, the Herba Blumeae Laciniatae 29 parts, Rhizoma et radix smilacis santis 13 parts, Herba Aristolochiae Mollissimae 10 parts, Lignum Pini Nodi 6 parts, Rhizoma Polygonati 17 parts, Rhizoma Cibotii 23 parts and Radix Oenotherae erythrosepalae 23 parts, in external used medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Radix Triplostegiae Grandiflorae 27 parts, Radix Et Caulis Acanthopanacis Senticosi 26 parts, Radix polygalae arillatae 24 parts, Herba Origani 21 parts, Radix seu folium Gaultheriae intermediae 28 parts, Radix et rhizoma smilacinae japonicae 19 parts, 18 parts, Flos Carthami, Rhizoma anemones davidii 12 parts, Radix seu Folium Heliciae cochinchinensis 12 parts, Concha Arcae 12 parts, expectorant medicine 17 parts, Chinese fanpalm seed 11 parts, Gaultheria 33 parts, the Herba Blumeae Laciniatae 27 parts, Rhizoma et radix smilacis santis 20 parts, Herba Aristolochiae Mollissimae 15 parts, Lignum Pini Nodi 14 parts, Rhizoma Polygonati 13 parts, Rhizoma Cibotii 28 parts, Radix Oenotherae erythrosepalae 19 parts, Cortex Sorbariae Arboreae 6 parts, The Iron Buddha 4 parts, Radix delphinii fargesii 7 parts and 3 parts, Pericarpium Zanthoxyli.
In order to realize goal of the invention better, the present invention also provides a kind of preparation method for the treatment of the endo-medicine of the pharmaceutical preparation of type of stagnation of blood stasis bony spur, and when the dosage form of described endo-medicine is honey refining pill, its preparation method comprises the following steps:
Step 1: first Radix Triplostegiae Grandiflorae, Radix et Rhizoma Smilacis Ripariae, Radix Et Caulis Acanthopanacis Senticosi, Radix polygalae arillatae, Radix seu folium Gaultheriae intermediae, Radix et rhizoma smilacinae japonicae, Concha Arcae were pulverized 180-200 mesh sieve, and obtained powder;
Step 2: get surplus stock medical material again and mix in described ratio, add relative to 83-94% soak with ethanol 1-2 hour of mixture 2-6 times amount, heating extraction 2 times, each 1-1.5 hour, merge extractive liquid, 124-150 order filter, be the ultrafiltration post ultrafiltration of 4400-98000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 65 DEG C, relative density is the extractum of 1.34, becomes component 1;
Step 3: step 2 medicine slag is added 1-3 times amount water soaking 1-2.5 hour, extract 1 time, extraction time is 1.5-2 hour, and thickening filtration is extractum shape, is component 2.
Step 4: said components 1 and component 2 two kinds of extractum are condensed into pasty state, add the powder that step 1 obtains, add Mel and be twisted into pill.
In order to realize goal of the invention better, the present invention also provides a kind of preparation method for the treatment of the endo-medicine of the pharmaceutical preparation of type of stagnation of blood stasis bony spur, and when the dosage form of described endo-medicine is capsule, its preparation method comprises the following steps:
The first step, first pulverized 180-200 mesh sieve by Radix Triplostegiae Grandiflorae, Radix et Rhizoma Smilacis Ripariae, Radix Et Caulis Acanthopanacis Senticosi, Radix polygalae arillatae, Radix seu folium Gaultheriae intermediae, Radix et rhizoma smilacinae japonicae, Concha Arcae, obtained powder;
Second step, Gaultheria, the Herba Blumeae Laciniatae and Rhizoma et radix smilacis santis are mixed in described ratio, add relative to mixture 2 ~ 5 times amount determining alcohol be 75% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter respectively, each time filtrate merges, and reclaims ethanol, when being concentrated into 45 DEG C, relative density is the clear paste of 1.30 ~ 1.40, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 3 ~ 5 hours, filter, and when being concentrated into 50 DEG C, relative density is the clear paste of 1.22 ~ 1.30;
4th step, mixed by the powder of the clear paste of second step, the 3rd step and the first step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, add the mixture relative to dried cream powder described in 100 weight portions subsequently, 5 ~ 7 weight portion carboxymethyl starch sodium, 5 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, drying, granulate, adds the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.
In order to realize goal of the invention better, the present invention also provides a kind of preparation method for the treatment of the external used medicine of the pharmaceutical preparation of type of stagnation of blood stasis bony spur, and when the dosage form of described external used medicine is patch, its preparation method comprises the following steps:
The first step, mixes Cortex Sorbariae Arboreae, The Iron Buddha, Radix delphinii fargesii and Pericarpium Zanthoxyli in described ratio, adds the soaking in Chinese liquor 5-7 days relative to mixture 8 ~ 10 times amount 50 degree, and filtering relative density when filtrate being concentrated into 50 DEG C is the clear paste of 1.23 ~ 1.30;
Second step, pulverized 180-200 mesh sieve by Radix Triplostegiae Grandiflorae, Radix et Rhizoma Smilacis Ripariae, Radix Et Caulis Acanthopanacis Senticosi, Radix polygalae arillatae, Radix seu folium Gaultheriae intermediae, Radix et rhizoma smilacinae japonicae, Concha Arcae, obtained powder;
3rd step, soaks 1-2 hour by described surplus stock medical material in described ratio mixing, is then placed in multi-function extractor, and first time decocts 5-10 times that amount of water is medical material, decoct, when being heated to 100 DEG C, start timing, micro-boil 2 hours after, from feed opening filter release medicinal liquid, put in fluid reservoir; Second time decocts, and amount of water is medical material 5-10 times amount, is heated to 100 DEG C, micro-boil 2 hours after, extract medicinal liquid out, merge with the medicinal liquid that decocts of first time; To merge in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, being concentrated into relative density is 1.20, the extractum of temperature to 60 DEG C-70 DEG C, cooling, after ultraviolet radiation sterilizing, the powder mix homogeneously of the clear paste and second step that add the first step obtains mixture, then adds relative to the rubber of 2 times of described mixture sum, the Colophonium of 2 times, mix homogeneously, carry out painting cream, cut off, lid lining, section, namely obtains described patch.
For solving the problems of the technologies described above, the present invention reoffers a kind of endo-medicine dosage form for the treatment of the pharmaceutical preparation of type of stagnation of blood stasis bony spur, and pharmaceutical dosage form can be: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, syrup, sublimed preparation, solution; External drug dosage forms injection, suppository, plaster, enema and patch.
Described pharmaceutical preparation, medicine is decocted decoction in use and is taken, and every day 1 dose, decocting takes at twice, and every 20 days is a course for the treatment of; When this pharmaceutical preparation be pill, capsule or tablet, suck agent, honey refining pill use time, three times on the one, every 20 days is a course for the treatment of; When this pharmaceutical preparation is unguentum, patch use, three times on the one, every 20 days is a course for the treatment of.
The invention has the beneficial effects as follows: the present invention with QI invigorating of invigorating blood circulation, blood stasis-eliminating and stagnation-dissipating, dispersing cold for relieving pain, bone and muscle strengthening is Therapeutic Principle, cures mainly type of stagnation of blood stasis bony spur; Formula is simple, and processing technology is easy, the little and convenient drug administration of toxic and side effects, and medicament is easy to manufacture, with low cost, focus of going directly, and healing time is short, not easily recurs after healing; Pharmaceutical preparation of the present invention, the Chinese medicine that selected abnormal smells from the patient is gentle, makes the abnormal smells from the patient of pharmaceutical preparation and light; The present invention adopts the pharmaceutical preparation material of different properties, has carried out scientific compatibility, can reach desirable therapeutic effect and safety.
Detailed description of the invention
The traditional Chinese medical science claims bony spur to be rheumatism involving the bone.Rheumatism involving the bone belongs to one of five body constituents numbness.All heresies by six climate exopathogens invade and harass human body muscles and bones joint, and impatency passages through which vital energy circulates QI and blood, occurs that limbs are heavy, joint severe pain, and limbs contracture flexing even occurs, or the rheumatism involving the bone of tetanic lopsided person's meaning.Doctor trained in Western medicine osteoarthritis belongs to traditional Chinese medical science rheumatism involving the bone category, and it is a kind of chronic joint disease being feature with the degeneration of articular cartilage, destruction and hyperosteogeny.For the corresponding symptom suffering from the appearance of deficiency of yang type bony spur, the invention provides one has with the kidney invigorating invigorating YANG, hard masses softening and resolving is Therapeutic Principle, hold concurrently with blood circulation promoting and blood stasis dispelling, mend the raw marrow of essence solid bone, removing obstruction in the collateral to relieve pain, the tonify deficiency that stimulates the menstrual flow, invigorating the kidney and strengthening the bones, cure mainly pharmaceutical preparation of type of stagnation of blood stasis bony spur and preparation method thereof.
Therefore; the present invention is with QI invigorating of invigorating blood circulation; blood stasis-eliminating and stagnation-dissipating; dispersing cold for relieving pain; bone and muscle strengthening is Therapeutic Principle; treatment type of stagnation of blood stasis bony spur, selects prescription for oral administration: Radix Triplostegiae Grandiflorae, Radix et Rhizoma Smilacis Ripariae, Radix Et Caulis Acanthopanacis Senticosi, Radix polygalae arillatae, Herba Origani, Radix Jasmini Giraldii, Radix seu folium Gaultheriae intermediae, Radix et rhizoma smilacinae japonicae, Flos Carthami, Rhizoma anemones davidii, Radix seu Folium Heliciae cochinchinensis, Concha Arcae, expectorant medicine, Chinese fanpalm seed, Gaultheria, the Herba Blumeae Laciniatae, Rhizoma et radix smilacis santis, Herba Aristolochiae Mollissimae, Lignum Pini Nodi, Rhizoma Polygonati, Rhizoma Cibotii and Radix Oenotherae erythrosepalae; Exterior-applied prescription: Radix Triplostegiae Grandiflorae, Radix Et Caulis Acanthopanacis Senticosi, Radix polygalae arillatae, Herba Origani, Radix seu folium Gaultheriae intermediae, Radix et rhizoma smilacinae japonicae, Flos Carthami, Rhizoma anemones davidii, Radix seu Folium Heliciae cochinchinensis, Concha Arcae, expectorant medicine, Chinese fanpalm seed, Gaultheria, the Herba Blumeae Laciniatae, Rhizoma et radix smilacis santis, Herba Aristolochiae Mollissimae, Lignum Pini Nodi, Rhizoma Polygonati, Rhizoma Cibotii, Radix Oenotherae erythrosepalae, Cortex Sorbariae Arboreae, The Iron Buddha, Radix delphinii fargesii and Pericarpium Zanthoxyli.
Wherein, Radix Triplostegiae Grandiflorae in side, Radix et Rhizoma Smilacis Ripariae, Radix Et Caulis Acanthopanacis Senticosi, Radix polygalae arillatae are invigorated blood circulation QI invigorating, Herba Origani, Radix Jasmini Giraldii, Radix seu folium Gaultheriae intermediae, Radix et rhizoma smilacinae japonicae, Flos Carthami, Rhizoma anemones davidii, Radix seu Folium Heliciae cochinchinensis blood circulation promoting and blood stasis dispelling, Concha Arcae, expectorant medicine, Chinese fanpalm seed hard masses softening and resolving; Gaultheria, the Herba Blumeae Laciniatae, Rhizoma et radix smilacis santis, Herba Aristolochiae Mollissimae, Lignum Pini Nodi, expelling wind and dampness for relieving pain, Rhizoma Polygonati, Rhizoma Cibotii, Radix Oenotherae erythrosepalae the kidney invigorating bone strengthening, Cortex Sorbariae Arboreae, The Iron Buddha, Radix delphinii fargesii and Pericarpium Zanthoxyli promoting blood circulation and stopping pain.
Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:
Radix Triplostegiae Grandiflorae: sweet, micro-hardship is flat.Tonifying speen and tonifying kidney, promoting blood flow to regulate menstruation, only metrorrhagia, removing toxic substances.For lumbago due to renal deficiency, anemia, cough, seminal emission, sexual impotence, rheumatic arthritis, menoxenia, vicarious menstruation, metrorrhagia, leukorrhagia, infertility.External is stopped blooding.
Radix et Rhizoma Smilacis Ripariae: sweet, bitter is flat.Dispelling, collateral-activating, expelling phlegm for arresting cough.For rheumatic arthritis, bones and muscles pain, traumatic injury, lumbar muscle strain, bronchitis, pulmonary tuberculosis cough spitting of blood.Wind-damp dispelling, promoting blood circulation to remove obstruction in the collateral, anti-inflammatory analgesic, treating rheumatic arthritis, bones and muscles pain, the hemiplegia of caused by hypertension, osteomyelitis, bone tuberculosis.
Radix Et Caulis Acanthopanacis Senticosi: pungent, micro-hardship, temperature.Return spleen, kidney, heart channel.Replenishing kidney, strengthening waist; Benefiting vital QI for tranquillizing; Promoting blood circulation to remove obstruction in the collateral.Replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization.For deficiency of spleen-YANG and kidneyYANG, body void is weak, inappetence, soreness of waist and knee joint, insomnia and dreamful sleep.
Radix polygalae arillatae: sweet, temperature.Inrigorating qi and promoting blood circulation, expelling wind and removing dampness.For pulmonary tuberculosis, puerperal asthenia, menoxenia, leucorrhea, uterine prolapse, hepatitis, rheumatalgia, traumatic injury.
Herba Origani: acrid in the mouth; Slightly warm in nature.Return lung; Stomach warp.Blood circulation promoting and blood stasis dispelling, pain relieving granulation promoting, sensible sharp diaphragm, regulating menstruation.Control traumatic injury, fracture, chest and diaphragm distension, metrorrhagia, leucorrhea.Diaphoresis, expelling summer-heat, diuresis.Summer catches a cold, fever without perspiration, heatstroke, and acute gastroenteritis is uncomfortable in chest, halitosis, dysuria.
Radix Jasmini Giraldii: micro-hardship, puckery, temperature.Blood circulation promoting and blood stasis dispelling, granulation promoting, convergence.Cure mainly traumatic injury, stagnant in blood stasis, fracture, knife injury.
Radix seu folium Gaultheriae intermediae: bitter, pungent, temperature.Blood circulation promoting and blood stasis dispelling, expelling wind and removing dampness.Root bark, leaf: for rheumatic arthritis, puerperal lumbago, chronic enteritis, diarrhoea; Fracture is controlled in external, traumatic injury.Flower: control blood stasis amenorrhea.
Radix et rhizoma smilacinae japonicae: sweet, bitter, temperature.Wind-expelling pain-stopping, promoting blood circulation and detumescence.For rheumatic ostalgia, nervous headache; Mastitis are controlled in external, carbuncle furuncle and phyma poison, traumatic injury.
Flos Carthami: pungent, temperature.GUIXIN, Liver Channel.Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.
Rhizoma anemones davidii: micro-hardship, temperature.Blood circulation promoting and blood stasis dispelling, kidney invigorating and YANG supporting.For traumatic injury, lumbar muscle strain, sexual impotence.
Radix seu Folium Heliciae cochinchinensis: bitter, cool.Promoting flow of QI and blood, stasis-dispelling and pain-killing.Cure mainly traumatic injury, swell and ache, traumatic hemorrhage.Wind-expelling pain-stopping; Promoting blood circulation and detumescence; Astringing to arrest bleeding.Main rheumatic ostalgia; Traumatic injury congestive edema; Traumatic hemorrhage
Concha Arcae: salty is flat.Return lung, stomach, Liver Channel.Expectorant blood stasis dispelling, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache.For the long-pending knot of pertinacious phlegm, sticky difficulty is coughed up, goiter, scrofula, lump in the abdomen mass in the abdomen, stomachache pantothenic acid.
Expectorant medicine: micro-hardship, puckery is flat.Hard masses softening and resolving, expelling wind and removing dampness, dredge the meridian passage.For tuberculous lymphadenitis, traumatic injury, lumbago due to renal deficiency, rheumatalgia, amenorrhea, dysmenorrhea.
Chinese fanpalm seed: sweet in the mouth; Bitter; Property is put down; Mild toxicity.Blood circulation promoting and blood stasis dispelling; Hard masses softening and resolving.Main chronic hepatitis; Lump in the abdomen.
Gaultheria: pungent, temperature.Expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral, promoting blood circulation and stopping pain.For rheumatic arthritis, traumatic injury, cold syndrome of the stomach pain.Anemofrigid cold.
The Herba Blumeae Laciniatae: pungent, bitter, temperature.Expelling wind and removing dampness, dredge the meridian passage.For rheumatic ostalgia, headache, treating swelling and pain by traumatic injury, eczema, venom.
Rhizoma et radix smilacis santis: bitter in the mouth, property is put down, nontoxic.Expelling wind and removing dampness, activating blood cirulation to regulate QI flow, pain relieving.Dispelling the wind and dampness pathogens pain, traumatic injury, traumatic hemorrhage, fishbone bone stuck in the throat.
Herba Aristolochiae Mollissimae: pungent, bitter is flat.Return Liver Channel.Dispelling wind and removing obstruction in the collateral, pain relieving.For rheumatic arthralgia, stomachache ， testis swells and ache, the diseases such as traumatic pain.The ground part of Aristolochiaceae herbaceous plant Aristolochia mollissima.
Lignum Pini Nodi: bitter, temperature.Expelling wind and removing dampness, activating collaterals to relieve pain.For rheumatic arthritis, lumbago and skelalgia, Kaschin-Beck disease, treating swelling and pain by traumatic injury.
Rhizoma Polygonati: sweet is flat.Return spleen, lung, kidney channel.Boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst.
Rhizoma Cibotii: bitter, sweet, temperature.Return liver, kidney channel.Invigorating the liver and kidney, strong spinal column, wind-damp dispelling.For soreness of the waist and knees, weakness of the lower extremities, rheumatic arthralgia.
Radix Oenotherae erythrosepalae: sweet, temperature.Bone and muscle strengthening, expelling wind and removing dampness.Mainly curing rheumatism, bones and muscles pain.
Cortex Sorbariae Arboreae: bitter, cold.Poisonous.Promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain.For fracture, traumatic injury, articular sprain congestion and swelling pain, rheumatic arthritis.
The Iron Buddha: pungent, temperature.Very toxic.Expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral, pain relieving.For local anesthesia, rheumatic numbness, lumbago and skelalgia, articular sprain.
Radix delphinii fargesii: pungent, heat.Poisonous.Expelling wind and removing dampness, temperature three-way meridian, pain relieving.For rheumatism bones and muscles pain, numb, paralysis.
Pericarpium Zanthoxyli: pungent; Warm in nature; Mild toxicity.Spleen; Lung; Liver; Kidney; The heart; Pericardium channel.Warming middle-JIAO to relieve pain; Dehumidifying antidiarrheal; Killing parasites for relieving itching.The coldness and pain in the epigastrium of main Deficiency and coldness of spleen and stomach; Ascarid is suffered from abdominal pain; Vomiting is had loose bowels; Lung cold cough with asthma; Lung cold cough with asthma; Toothache due to dental caries; Pudendal pruritus leukorrhagia; Eczema skin pruritus
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure reaching technique effect can fully understand and implement according to this.
The preparation method of embodiment 1 honey refining pill 1 for oral administration of the present invention
Get Radix Triplostegiae Grandiflorae 26g, Radix et Rhizoma Smilacis Ripariae 21g, Radix Et Caulis Acanthopanacis Senticosi 34g, Radix polygalae arillatae 36g, Herba Origani 16g, Radix Jasmini Giraldii 17g, Radix seu folium Gaultheriae intermediae 31g, Radix et rhizoma smilacinae japonicae 22g, Flos Carthami 18g, Rhizoma anemones davidii 12g, Radix seu Folium Heliciae cochinchinensis 17g, Concha Arcae 15g, expectorant medicine 19g, Chinese fanpalm seed 7g, Gaultheria 31g, Herba Blumeae Laciniatae 24g, Rhizoma et radix smilacis santis 16g, Herba Aristolochiae Mollissimae 8g, Lignum Pini Nodi 7g, Rhizoma Polygonati 14g, Rhizoma Cibotii 26g and Radix Oenotherae erythrosepalae 19g.
Its preparation method comprises the following steps:
Step 1: first Radix Triplostegiae Grandiflorae, Radix et Rhizoma Smilacis Ripariae, Radix Et Caulis Acanthopanacis Senticosi, Radix polygalae arillatae, Radix seu folium Gaultheriae intermediae, Radix et rhizoma smilacinae japonicae, Concha Arcae were pulverized 180 mesh sieves, and obtained powder;
Step 2: get surplus stock medical material again and mix in described ratio, add 90% soak with ethanol 1 hour, the heating extraction 2 times relative to mixture 3 times amount, each 1 hour, merge extractive liquid, 1150 orders filter, be the ultrafiltration post ultrafiltration of 98000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 65 DEG C, relative density is the extractum of 1.34, becomes component 1;
Step 3: step 2 medicine slag is added 1 times amount water soaking 1 hour, extract 1 time, extraction time is 2 hours, and thickening filtration is extractum shape, is component 2.
Step 4: said components 1 and component 2 two kinds of extractum are condensed into pasty state, add the powder that step 1 obtains, add Mel and be twisted into pill.
The preparation method of embodiment 2 oral capsule of the present invention
Get Radix Triplostegiae Grandiflorae 44g, Radix et Rhizoma Smilacis Ripariae 23g, Radix Et Caulis Acanthopanacis Senticosi 26g, Radix polygalae arillatae 29g, Herba Origani 25g, Radix Jasmini Giraldii 22g, Radix seu folium Gaultheriae intermediae 27g, Radix et rhizoma smilacinae japonicae 26g, Flos Carthami 27g, Rhizoma anemones davidii 15g, Radix seu Folium Heliciae cochinchinensis 12g, Concha Arcae 17g, expectorant medicine 23g, Chinese fanpalm seed 12g, Gaultheria 33g, Herba Blumeae Laciniatae 32g, Rhizoma et radix smilacis santis 19g, Herba Aristolochiae Mollissimae 12g, Lignum Pini Nodi 11g, Rhizoma Polygonati 18g, Rhizoma Cibotii 28g and Radix Oenotherae erythrosepalae 24g.
Its preparation method comprises the following steps:
The first step, first pulverized 200 mesh sieves by Radix Triplostegiae Grandiflorae, Radix et Rhizoma Smilacis Ripariae, Radix Et Caulis Acanthopanacis Senticosi, Radix polygalae arillatae, Radix seu folium Gaultheriae intermediae, Radix et rhizoma smilacinae japonicae, Concha Arcae, obtained powder;
Second step, mixes Gaultheria, the Herba Blumeae Laciniatae and Rhizoma et radix smilacis santis in described ratio, add relative to mixture 3 times amount determining alcohol be 90% alcohol reflux 4 times, each 2 hours, filter respectively, each time filtrate merges, reclaim ethanol, when being concentrated into 45 DEG C, relative density is the clear paste of 1.40, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 times of water gagings, boil 4 hours, filter, and when being concentrated into 50 DEG C, relative density is the clear paste of 1.22;
4th step, mixed by the powder of the clear paste of second step, the 3rd step and the first step, 70 DEG C of reduced vacuum dryings, get dry extract powder;
5th step, add the mixture relative to dried cream powder described in 100 weight portions subsequently, 5 weight portion carboxymethyl starch sodium, 30 weight starch mix homogeneously, adding 200 weight portion determining alcohols is 90% alcohol granulation, drying, granulate, adds the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 weight portion magnesium stearate, then load in gelatine capsule.
The preparation method of embodiment 3 honey refining pill 2 for oral administration of the present invention
Get Radix Triplostegiae Grandiflorae 35g, Radix et Rhizoma Smilacis Ripariae 15g, Radix Et Caulis Acanthopanacis Senticosi 40g, Radix polygalae arillatae 23g, Herba Origani 21g, Radix Jasmini Giraldii 15g, Radix seu folium Gaultheriae intermediae 34g, Radix et rhizoma smilacinae japonicae 15g, Flos Carthami 24g, Rhizoma anemones davidii 10g, Radix seu Folium Heliciae cochinchinensis 23g, Concha Arcae 12g, expectorant medicine 14g, Chinese fanpalm seed 11g, Gaultheria 23g, Herba Blumeae Laciniatae 29g, Rhizoma et radix smilacis santis 13g, Herba Aristolochiae Mollissimae 10g, Lignum Pini Nodi 6g, Rhizoma Polygonati 17g, Rhizoma Cibotii 23g and Radix Oenotherae erythrosepalae 23g.
Its preparation method comprises the following steps:
Step 1: first Radix Triplostegiae Grandiflorae, Radix et Rhizoma Smilacis Ripariae, Radix Et Caulis Acanthopanacis Senticosi, Radix polygalae arillatae, Radix seu folium Gaultheriae intermediae, Radix et rhizoma smilacinae japonicae, Concha Arcae were pulverized 180-200 mesh sieve, and obtained powder;
Step 2: get surplus stock medical material again and mix in described ratio, add 94% soak with ethanol 1 hour, the heating extraction 2 times relative to mixture 5 times amount, each 1 hour, merge extractive liquid, 130 orders filter, be the ultrafiltration post ultrafiltration of 4400 again through the molecular weight that dams, when ultrafiltrate is evaporated to 65 DEG C, relative density is the extractum of 1.34, becomes component 1;
Step 3: step 2 medicine slag is added 2 times amount water soaking 2 hours, extract 1 time, extraction time is 2 hours, and thickening filtration is extractum shape, is component 2.
Step 4: said components 1 and component 2 two kinds of extractum are condensed into pasty state, add the powder that step 1 obtains, add Mel and be twisted into pill.
The preparation method of embodiment 4 external use plaster 1 of the present invention
Get Radix Triplostegiae Grandiflorae 38g, Radix Et Caulis Acanthopanacis Senticosi 21g, Radix polygalae arillatae 28g, Herba Origani 16g, Radix seu folium Gaultheriae intermediae 35g, Radix et rhizoma smilacinae japonicae 15g, Flos Carthami 25g, Rhizoma anemones davidii 10g, Radix seu Folium Heliciae cochinchinensis 21g, Concha Arcae 15g, expectorant medicine 14g, Chinese fanpalm seed 12g, Gaultheria 32g, Herba Blumeae Laciniatae 31g, Rhizoma et radix smilacis santis 18g, Herba Aristolochiae Mollissimae 17g, Lignum Pini Nodi 10g, Rhizoma Polygonati 15g, Rhizoma Cibotii 23g, Radix Oenotherae erythrosepalae 21g, Cortex Sorbariae Arboreae 4g, The Iron Buddha 8g, Radix delphinii fargesii 3g and Pericarpium Zanthoxyli 5g.
Its preparation method comprises the following steps:
The first step, mixes Cortex Sorbariae Arboreae, The Iron Buddha, Radix delphinii fargesii and Pericarpium Zanthoxyli in described ratio, adds the soaking in Chinese liquor 5 days relative to mixture 8 times amount 50 degree, and filtering relative density when filtrate being concentrated into 50 DEG C is the clear paste of 1.28;
Second step, pulverized 180 mesh sieves by Radix Triplostegiae Grandiflorae, Radix et Rhizoma Smilacis Ripariae, Radix Et Caulis Acanthopanacis Senticosi, Radix polygalae arillatae, Radix seu folium Gaultheriae intermediae, Radix et rhizoma smilacinae japonicae, Concha Arcae, obtained powder;
3rd step, by described surplus stock medical material in described ratio mixing immersion 1 hour, be then placed in multi-function extractor, first time decocts 6 times that amount of water is medical material, decoct, when being heated to 100 DEG C, start timing, micro-boil 2 hours after, from feed opening filter release medicinal liquid, put in fluid reservoir; Second time decocts, and amount of water is medical material 7 times amount, is heated to 100 DEG C, micro-boil 2 hours after, extract medicinal liquid out, merge with the medicinal liquid that decocts of first time; To merge in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.06MPa, temperature remains on 70 DEG C, being concentrated into relative density is 1.20, the extractum of temperature to 70 DEG C, cooling, after ultraviolet radiation sterilizing, the powder mix homogeneously of the clear paste and second step that add the first step obtains mixture, then adds relative to the rubber of 2 times of described mixture sum, the Colophonium of 2 times, mix homogeneously, carry out painting cream, cut off, lid lining, section, namely obtains described patch.
The preparation method of embodiment 5 external use plaster 2 of the present invention
Get Radix Triplostegiae Grandiflorae 40g, Radix Et Caulis Acanthopanacis Senticosi 33g, Radix polygalae arillatae 32g, Herba Origani 25g, Radix seu folium Gaultheriae intermediae 37g, Radix et rhizoma smilacinae japonicae 26g, Flos Carthami 27g, Rhizoma anemones davidii 15g, Radix seu Folium Heliciae cochinchinensis 23g, Concha Arcae 17g, expectorant medicine 23g, Chinese fanpalm seed 7g, Gaultheria 23g, Herba Blumeae Laciniatae 36g, Rhizoma et radix smilacis santis 22g, Herba Aristolochiae Mollissimae 21g, Lignum Pini Nodi 17g, Rhizoma Polygonati 17g, Rhizoma Cibotii 26g, Radix Oenotherae erythrosepalae 23g, Cortex Sorbariae Arboreae 8g, The Iron Buddha 6g, Radix delphinii fargesii 5g and Pericarpium Zanthoxyli 7g.
Its preparation method comprises the following steps:
The first step, mixes Cortex Sorbariae Arboreae, The Iron Buddha, Radix delphinii fargesii and Pericarpium Zanthoxyli in described ratio, adds the soaking in Chinese liquor 6 days relative to mixture 10 times amount 50 degree, and filtering relative density when filtrate being concentrated into 50 DEG C is the clear paste of 1.26;
Second step, pulverized 200 mesh sieves by Radix Triplostegiae Grandiflorae, Radix et Rhizoma Smilacis Ripariae, Radix Et Caulis Acanthopanacis Senticosi, Radix polygalae arillatae, Radix seu folium Gaultheriae intermediae, Radix et rhizoma smilacinae japonicae, Concha Arcae, obtained powder;
3rd step, by described surplus stock medical material in described ratio mixing immersion 1 hour, be then placed in multi-function extractor, first time decocts 8 times that amount of water is medical material, decoct, when being heated to 100 DEG C, start timing, micro-boil 2 hours after, from feed opening filter release medicinal liquid, put in fluid reservoir; Second time decocts, and amount of water is medical material 7 times amount, is heated to 100 DEG C, micro-boil 2 hours after, extract medicinal liquid out, merge with the medicinal liquid that decocts of first time; To merge in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.03MPa, temperature remains on 70 DEG C, being concentrated into relative density is 1.20, temperature to 60 DEG C extractum, cooling, after ultraviolet radiation sterilizing, the powder mix homogeneously of the clear paste and second step that add the first step obtains mixture, then adds relative to the rubber of 2 times of described mixture sum, the Colophonium of 2 times, mix homogeneously, carry out painting cream, cut off, lid lining, section, namely obtains described patch.
The preparation method of embodiment 6 external use plaster 3 of the present invention
Get Radix Triplostegiae Grandiflorae 27g, Radix Et Caulis Acanthopanacis Senticosi 26g, Radix polygalae arillatae 24g, Herba Origani 21g, Radix seu folium Gaultheriae intermediae 28g, Radix et rhizoma smilacinae japonicae 19g, Flos Carthami 18g, Rhizoma anemones davidii 12g, Radix seu Folium Heliciae cochinchinensis 12g, Concha Arcae 12g, expectorant medicine 17g, Chinese fanpalm seed 11g, Gaultheria 33g, Herba Blumeae Laciniatae 27g, Rhizoma et radix smilacis santis 20g, Herba Aristolochiae Mollissimae 15g, Lignum Pini Nodi 14g, Rhizoma Polygonati 13g, Rhizoma Cibotii 28g, Radix Oenotherae erythrosepalae 19g, Cortex Sorbariae Arboreae 6g, The Iron Buddha 4g, Radix delphinii fargesii 7g and Pericarpium Zanthoxyli 3g.
Its preparation method comprises the following steps:
The first step, mixes Cortex Sorbariae Arboreae, The Iron Buddha, Radix delphinii fargesii and Pericarpium Zanthoxyli in described ratio, adds the soaking in Chinese liquor 6 days relative to mixture 9 times amount 50 degree, and filtering relative density when filtrate being concentrated into 50 DEG C is the clear paste of 1.30;
Second step, pulverized 180 mesh sieves by Radix Triplostegiae Grandiflorae, Radix et Rhizoma Smilacis Ripariae, Radix Et Caulis Acanthopanacis Senticosi, Radix polygalae arillatae, Radix seu folium Gaultheriae intermediae, Radix et rhizoma smilacinae japonicae, Concha Arcae, obtained powder;
3rd step, by described surplus stock medical material in described ratio mixing immersion 2 hours, be then placed in multi-function extractor, first time decocts 8 times that amount of water is medical material, decoct, when being heated to 100 DEG C, start timing, micro-boil 2 hours after, from feed opening filter release medicinal liquid, put in fluid reservoir; Second time decocts, and amount of water is medical material 7 times amount, is heated to 100 DEG C, micro-boil 2 hours after, extract medicinal liquid out, merge with the medicinal liquid that decocts of first time; To merge in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.08MPa, temperature remains on 60 DEG C, being concentrated into relative density is 1.20, the extractum of temperature to 60 DEG C, cooling, after ultraviolet radiation sterilizing, the powder mix homogeneously of the clear paste and second step that add the first step obtains mixture, then adds relative to the rubber of 2 times of described mixture sum, the Colophonium of 2 times, mix homogeneously, carry out painting cream, cut off, lid lining, section, namely obtains described patch.
Diagnostic criteria:
Diagnostic criteria is drafted with reference to " Chinese medical disease Standardization of diagnosis and curative effect ".Clinical manifestation is arthralgia and function limitation, and x-ray inspection or the visible bony spur of CT examination are formed or edge lip sample hypertrophy, and lab testing gets rid of the diseases such as rheumatic arthritis, rheumatoid arthritis, gout.Check can establish diagnosis according to medical history, symptom and sign and bat X anterioposterior and lateral film or CT.
(1) bone sound is had during the joint motion of the diagnosis of bony spur;
(2) first 1 month most of time has pain;
(3) age is more than or equal to 38 years old;
(4) morning, deadlock was less than 30 minutes, can as the diagnostic criteria of knee joint bony spur; Or knee joint inspection has bone loose.
Chinese medical discrimination type of stagnation of blood stasis: joint sting, sore spot is fixed, joint deformity, movable unfavorable, or the curved back of the body camel of waist, dim complexion.Words are purple dark, deep pulse or carefully puckery.
Efficacy assessment standard:
Draft with reference to " Chinese medical disease Standardization of diagnosis and curative effect ".
Clinical cure: clinical symptoms, sign disappear, local without tenderness, activity freely, the non-recidivist of follow-up observation more than at least 1 year;
Effective: clinical symptom disappearance, sign is obviously improved, and pain obviously alleviates, time movable without or occasionally have mild pain, or only tired or Changes in weather time have mild pain, follow up a case by regular visits to not recurrence in 1 year;
Effective: clinical symptoms, sign are improved, heavy time light during pain, can be induced in the situation of Changes in weather or fatigue, occasionally have rebound phenomenon, but symptom, sign can be died away;
Invalid: symptom and sign are not improved, and even increase the weight of.
Toxicity test:
Acute toxicity test: application NIH mice 60, SPF level, male and female half and half, body weight 17 ~ 24g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The honey refining pill 1 prepared by embodiments of the invention 1 is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage honey refining of the present invention pill 1 LD50>28.7 crude drug/kg, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Pharmaceutical preparation clinical application amount of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage pharmaceutical preparation of the present invention is 745 times of quantity.Therefore honey refining pill 1 acute toxicity of the embodiment of the present invention 1 is low, clinical drug safety.
Long term toxicity test: the capsule of the embodiment of the present invention 2 is pressed 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of pharmaceutical preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that pharmaceutical preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Long term toxicity test: by the honey of the embodiment of the present invention 3 refining pill 2 pairs of mices by 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of pharmaceutical preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that pharmaceutical preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Hypersensitive test:
Get healthy albino guinea-pig 18, body weight 250-300g, male and female dual-purpose, reject both sides dorsal body setae before test, every side 3 × 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration; The test group external use plaster 1 of the embodiment of the present invention 4.Get the external use plaster 1 of the embodiment of the present invention 4 in unhairing district, back, the next day 1 time, totally 3 times.In latter 14 days of last contact, to lose money in a business product at back the same area, at once observe after removing medicine after 6h, and in 24,48,72h observes with or without anaphylaxis.Blank group and positive controls excite by same method and contact and observe.Result of the test: namely positive controls animal skin occurs localized erythema and slight edema in sensitization after 1 hour, within 24 hours, symptoms of allergic increases the weight of, and have scleroma to be formed, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.
Get healthy albino guinea-pig 18, body weight 250-300g, male and female dual-purpose, reject both sides dorsal body setae before test, every side 3 × 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration; The test group external use plaster 2 of the embodiment of the present invention 5.The external use plaster 2 getting the embodiment of the present invention 5 is affixed on unhairing district, back, the next day 1 time, totally 3 times.In latter 14 days of last contact, to lose money in a business product at back the same area, at once observe after removing medicine after 6h, and in 24,48,72h observes with or without anaphylaxis.Blank group and positive controls excite by same method and contact and observe.Result of the test: namely positive controls animal skin occurs localized erythema and slight edema in sensitization after 1 hour, within 24 hours, symptoms of allergic increases the weight of, and have scleroma to be formed, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.
Get healthy albino guinea-pig 18, body weight 250-300g, male and female dual-purpose, reject both sides dorsal body setae before test, every side 3 × 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration; The test group external use plaster 3 of the embodiment of the present invention 6.The external use plaster 3 getting the embodiment of the present invention 6 is affixed on unhairing district, back, the next day 1 time, totally 3 times.In latter 14 days of last contact, to lose money in a business product at back the same area, at once observe after removing medicine after 6h, and in 24,48,72h observes with or without anaphylaxis.Blank group and positive controls excite by same method and contact and observe.Result of the test: namely positive controls animal skin occurs localized erythema and slight edema in sensitization after 1 hour, within 24 hours, symptoms of allergic increases the weight of, and have scleroma to be formed, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.
Clinical data:
Man 104 example in 178 examples, female 74 example; Age 44-76 year; Sick time 3 months-15 years, average 4.5 years; Wherein, lumbar vertebra bone spur 35 example, calcanean spur 58 example, knee joint bony spur 59 example, strength vertebra thorn 26 example, occur in.Patient is divided into four groups at random; The ordinary circumstance of four groups of patients is as no difference of science of statistics such as sex, age, the courses of disease, and (P < 0.05), has comparability.
Honey refining pill 1 adds external use plaster 1 and treats treatment group: 45 people, male 26 people, female 19 people.Take honey refining pill 1 prepared by the embodiment of the present invention 1, every day 3 times, each 4, use the patch 1 of embodiment 4, every day 3 times 20 days is 1 course for the treatment of simultaneously.Treat clinical cure 30 people after two courses for the treatment of, effective 8 people, effective 5 people, invalid 2 people, total effective rate 95.6%.
Capsule adds external use plaster 2 and treats treatment group: 45 people, male 26 people, female 19 people.Take capsule prepared by the embodiment of the present invention 2, every day 3 times, each 4, use the patch 2 of embodiment 5, every day 3 times 20 days is 1 course for the treatment of simultaneously.Treat clinical cure 29 people after two courses for the treatment of, effective 10 people, effective 3 people, invalid 3 people, total effective rate 93.3%.
Honey refining pill 2 adds external use plaster 3 and treats treatment group: 44 people, male 26 people, female 18 people.Take honey refining pill 2 prepared by the embodiment of the present invention 3, every day 3 times, each 4, use the patch 3 of embodiment 6, every day 3 times 20 days is 1 course for the treatment of simultaneously.Treat clinical cure 31 people after two courses for the treatment of, effective 6 people, effective 4 people, invalid 3 people, total effective rate 93.2%.
Matched group: 44 people, male 26 people, female 18 people.Matched group: the spur and pain relieving liquid that oral Tongrentang Medicinal Liquor Factory, Beijing Tongrentang Co., Ltd. produces, every day 2 times, a 10 ~ 15ml 40 days is a course for the treatment of.Treat clinical cure 17 people after two courses for the treatment of, effective 15 people, effective 7 people, invalid 5 people, total effective rate 88.6%.
As can be seen from the above data, pharmaceutical preparation of the present invention is adopted to treat type of stagnation of blood stasis bony spur, relative to contrast groups Chinese medicine on therapeutic effect, there is significant improvement, the course for the treatment of shortens, and pharmaceutical preparation provided by the invention has that efficiency is high, determined curative effect, safety are high, the advantage that has no side effect.
Model case 1: patient Lee, man, 48 years old.Readme heel, sole tingle or paralysis sense about 9 months, show through calcaneus X line lateral projection: patient's calcaneus tuberosity place has bony spur to be formed.Walking disorder, dim complexion, purplish tongue is dark.X-ray film making display: biped is with trailing edge bony spur.Be diagnosed as bony spur, Chinese medical discrimination is type of stagnation of blood stasis.Take the honey refining pill 1 of the embodiment of the present invention 1, every day 3 times, each 4, be coated with the external use plaster 1 of the embodiment of the present invention 4, after treating 1 course for the treatment of, pain obviously alleviates simultaneously, continual cure 1 course for the treatment of, and clinical cure, follows up a case by regular visits to and do not recur for 1 year.
Model case 2: patient Yin certain, man, 61 years old.Frequent dizziness, headache, feel sick, x-ray inspection: C
4; , C
5:, C
6edge lip sample hypertrophy before and after vertebral body, purplish tongue is dark, and thready and hesitant pulse, is diagnosed as bony spur, and Chinese medical discrimination is type of stagnation of blood stasis.Take the capsule of the embodiment of the present invention 2, every day 3 times, each 4, use the external use plaster 2 of the embodiment of the present invention 5, treat after 30 days, katzeniammer obviously alleviates, continual cure 10 days, and clinical cure is followed up a case by regular visits to and do not recurred for 1 year half simultaneously.
Model case 3: patient Yao, man, 53 years old, within 5 years, front waist sprained treatment thoroughly, and waist is frequent, and right side leg is ached by buttocks radioactivity distally, and have feeling of numbness, during walking, pain increases the weight of, walking of can not standing erectly completely, and purplish tongue is dark, dim complexion, deep pulse.X-ray checks: have bony spur to be formed.Chinese medical discrimination is type of stagnation of blood stasis.Take the honey refining pill 2 of the embodiment of the present invention 3, every day 3 times, each 4, use the external use plaster 3 of the embodiment of the present invention 6 simultaneously, treat after 35 days, when pain in the lumbar region alleviates walking, pain slightly, continual cure 1 course for the treatment of, and clinical cure, follows up a case by regular visits to and do not recur for 3 years half.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (9)
1. treat the pharmaceutical preparation of type of stagnation of blood stasis bony spur for one kind; it is characterized in that; described pharmaceutical preparation is made up of endo-medicine and external used medicine, and described endo-medicine comprises following raw medicinal material: Radix Triplostegiae Grandiflorae, Radix et Rhizoma Smilacis Ripariae, Radix Et Caulis Acanthopanacis Senticosi, Radix polygalae arillatae, Herba Origani, Radix Jasmini Giraldii, Radix seu folium Gaultheriae intermediae, Radix et rhizoma smilacinae japonicae, Flos Carthami, Rhizoma anemones davidii, Radix seu Folium Heliciae cochinchinensis, Concha Arcae, expectorant medicine, Chinese fanpalm seed, Gaultheria, the Herba Blumeae Laciniatae, Rhizoma et radix smilacis santis, Herba Aristolochiae Mollissimae, Lignum Pini Nodi, Rhizoma Polygonati, Rhizoma Cibotii and Radix Oenotherae erythrosepalae;
Described external used medicine comprises following raw medicinal material: Radix Triplostegiae Grandiflorae, Radix Et Caulis Acanthopanacis Senticosi, Radix polygalae arillatae, Herba Origani, Radix seu folium Gaultheriae intermediae, Radix et rhizoma smilacinae japonicae, Flos Carthami, Rhizoma anemones davidii, Radix seu Folium Heliciae cochinchinensis, Concha Arcae, expectorant medicine, Chinese fanpalm seed, Gaultheria, the Herba Blumeae Laciniatae, Rhizoma et radix smilacis santis, Herba Aristolochiae Mollissimae, Lignum Pini Nodi, Rhizoma Polygonati, Rhizoma Cibotii, Radix Oenotherae erythrosepalae, Cortex Sorbariae Arboreae, The Iron Buddha, Radix delphinii fargesii and Pericarpium Zanthoxyli.
2. pharmaceutical preparation according to claim 1, it is characterized in that, in described endo-medicine, the ratio of weight and number of each raw medicinal material is: Radix Triplostegiae Grandiflorae 25-46 part, Radix et Rhizoma Smilacis Ripariae 13-25 part, Radix Et Caulis Acanthopanacis Senticosi 26-42 part, Radix polygalae arillatae 22-38 part, Herba Origani 14-27 part, Radix Jasmini Giraldii 13-24 part, Radix seu folium Gaultheriae intermediae 27-39 part, Radix et rhizoma smilacinae japonicae 14-28 part, Flos Carthami 16-29 part, Rhizoma anemones davidii 9-16 part, Radix seu Folium Heliciae cochinchinensis 11-25 part, Concha Arcae 10-19 part, expectorant medicine 13-24 part, Chinese fanpalm seed 6-14 part, Gaultheria 22-35 part, Herba Blumeae Laciniatae 23-34 part, Rhizoma et radix smilacis santis 11-20 part, Herba Aristolochiae Mollissimae 6-14 part, Lignum Pini Nodi 6-14 part, Rhizoma Polygonati 11-20 part, Rhizoma Cibotii 20-30 part and Radix Oenotherae erythrosepalae 19-28 part,
In described external used medicine, the ratio of weight and number of each raw medicinal material is:
Radix Triplostegiae Grandiflorae 25-41 part, Radix Et Caulis Acanthopanacis Senticosi 20-35 part, Radix polygalae arillatae 22-35 part, Herba Origani 14-27 part, Radix seu folium Gaultheriae intermediae 27-39 part, Radix et rhizoma smilacinae japonicae 14-28 part, Flos Carthami 16-29 part, Rhizoma anemones davidii 9-16 part, Radix seu Folium Heliciae cochinchinensis 11-25 part, Concha Arcae 10-19 part, expectorant medicine 13-24 part, Chinese fanpalm seed 6-14 part, Gaultheria 22-38 part, Herba Blumeae Laciniatae 26-39 part, Rhizoma et radix smilacis santis 16-24 part, Herba Aristolochiae Mollissimae 14-24 part, Lignum Pini Nodi 9-19 part, Rhizoma Polygonati 11-20 part, Rhizoma Cibotii 20-30 part, Radix Oenotherae erythrosepalae 19-28 part, Cortex Sorbariae Arboreae 4-9 part, The Iron Buddha 4-9 part, Radix delphinii fargesii 3-8 part and Pericarpium Zanthoxyli 3-8 part.
3. pharmaceutical preparation according to claim 1 and 2, it is characterized in that, in described endo-medicine, the ratio of weight and number of each raw medicinal material is: Radix Triplostegiae Grandiflorae 26-44 part, Radix et Rhizoma Smilacis Ripariae 15-23 part, Radix Et Caulis Acanthopanacis Senticosi 26-40 part, Radix polygalae arillatae 23-36 part, Herba Origani 16-25 part, Radix Jasmini Giraldii 15-22 part, Radix seu folium Gaultheriae intermediae 27-34 part, Radix et rhizoma smilacinae japonicae 15-26 part, Flos Carthami 18-27 part, Rhizoma anemones davidii 10-15 part, Radix seu Folium Heliciae cochinchinensis 12-23 part, Concha Arcae 12-17 part, expectorant medicine 14-23 part, Chinese fanpalm seed 7-12 part, Gaultheria 23-33 part, Herba Blumeae Laciniatae 24-32 part, Rhizoma et radix smilacis santis 13-19 part, Herba Aristolochiae Mollissimae 8-12 part, Lignum Pini Nodi 6-11 part, Rhizoma Polygonati 14-18 part, Rhizoma Cibotii 23-28 part and Radix Oenotherae erythrosepalae 19-24 part,
In described external used medicine, the ratio of weight and number of each raw medicinal material is:
Radix Triplostegiae Grandiflorae 27-40 part, Radix Et Caulis Acanthopanacis Senticosi 21-33 part, Radix polygalae arillatae 24-32 part, Herba Origani 16-25 part, Radix seu folium Gaultheriae intermediae 28-37 part, Radix et rhizoma smilacinae japonicae 15-26 part, Flos Carthami 18-27 part, Rhizoma anemones davidii 10-15 part, Radix seu Folium Heliciae cochinchinensis 12-23 part, 12-17 part, expectorant medicine 14-23 part, Chinese fanpalm seed 7-12 part, Gaultheria 23-33 part, Herba Blumeae Laciniatae 27-36 part, Rhizoma et radix smilacis santis 18-22 part, Herba Aristolochiae Mollissimae 15-21 part, Lignum Pini Nodi 10-17 part, Rhizoma Polygonati 13-17 part, Rhizoma Cibotii 23-28 part, Radix Oenotherae erythrosepalae 19-23 part, Cortex Sorbariae Arboreae 4-8 part, The Iron Buddha 4-8 part, Radix delphinii fargesii 3-7 part and Pericarpium Zanthoxyli 3-7 part.
4. according to the arbitrary described pharmaceutical preparation of claim 1-3; it is characterized in that, in described endo-medicine, the ratio of weight and number of each raw medicinal material is: Radix Triplostegiae Grandiflorae 26 parts, Radix et Rhizoma Smilacis Ripariae 21 parts, Radix Et Caulis Acanthopanacis Senticosi 34 parts, Radix polygalae arillatae 36 parts, Herba Origani 16 parts, Radix Jasmini Giraldii 17 parts, Radix seu folium Gaultheriae intermediae 31 parts, Radix et rhizoma smilacinae japonicae 22 parts, 18 parts, Flos Carthami, Rhizoma anemones davidii 12 parts, Radix seu Folium Heliciae cochinchinensis 17 parts, Concha Arcae 15 parts, expectorant medicine 19 parts, Chinese fanpalm seed 7 parts, Gaultheria 31 parts, the Herba Blumeae Laciniatae 24 parts, Rhizoma et radix smilacis santis 16 parts, Herba Aristolochiae Mollissimae 8 parts, Lignum Pini Nodi 7 parts, Rhizoma Polygonati 14 parts, Rhizoma Cibotii 26 parts and Radix Oenotherae erythrosepalae 19 parts;
In described external used medicine, the ratio of weight and number of each raw medicinal material is:
Radix Triplostegiae Grandiflorae 38 parts, Radix Et Caulis Acanthopanacis Senticosi 21 parts, Radix polygalae arillatae 28 parts, Herba Origani 16 parts, Radix seu folium Gaultheriae intermediae 35 parts, Radix et rhizoma smilacinae japonicae 15 parts, 25 parts, Flos Carthami, Rhizoma anemones davidii 10 parts, Radix seu Folium Heliciae cochinchinensis 21 parts, Concha Arcae 15 parts, expectorant medicine 14 parts, Chinese fanpalm seed 12 parts, Gaultheria 32 parts, the Herba Blumeae Laciniatae 31 parts, Rhizoma et radix smilacis santis 18 parts, Herba Aristolochiae Mollissimae 17 parts, Lignum Pini Nodi 10 parts, Rhizoma Polygonati 15 parts, Rhizoma Cibotii 23 parts, Radix Oenotherae erythrosepalae 21 parts, Cortex Sorbariae Arboreae 4 parts, The Iron Buddha 8 parts, Radix delphinii fargesii 3 parts and 5 parts, Pericarpium Zanthoxyli.
5. according to the arbitrary described pharmaceutical preparation of claim 1-3; it is characterized in that, in described endo-medicine, the ratio of weight and number of each raw medicinal material is: Radix Triplostegiae Grandiflorae 44 parts, Radix et Rhizoma Smilacis Ripariae 23 parts, Radix Et Caulis Acanthopanacis Senticosi 26 parts, Radix polygalae arillatae 29 parts, Herba Origani 25 parts, Radix Jasmini Giraldii 22 parts, Radix seu folium Gaultheriae intermediae 27 parts, Radix et rhizoma smilacinae japonicae 26 parts, 27 parts, Flos Carthami, Rhizoma anemones davidii 15 parts, Radix seu Folium Heliciae cochinchinensis 12 parts, Concha Arcae 17 parts, expectorant medicine 23 parts, Chinese fanpalm seed 12 parts, Gaultheria 33 parts, the Herba Blumeae Laciniatae 32 parts, Rhizoma et radix smilacis santis 19 parts, Herba Aristolochiae Mollissimae 12 parts, Lignum Pini Nodi 11 parts, Rhizoma Polygonati 18 parts, Rhizoma Cibotii 28 parts and Radix Oenotherae erythrosepalae 24 parts;
In described external used medicine, the ratio of weight and number of each raw medicinal material is:
Radix Triplostegiae Grandiflorae 40 parts, Radix Et Caulis Acanthopanacis Senticosi 33 parts, Radix polygalae arillatae 32 parts, Herba Origani 25 parts, Radix seu folium Gaultheriae intermediae 37 parts, Radix et rhizoma smilacinae japonicae 26 parts, 27 parts, Flos Carthami, Rhizoma anemones davidii 15 parts, Radix seu Folium Heliciae cochinchinensis 23 parts, Concha Arcae 17 parts, expectorant medicine 23 parts, Chinese fanpalm seed 7 parts, Gaultheria 23 parts, the Herba Blumeae Laciniatae 36 parts, Rhizoma et radix smilacis santis 22 parts, Herba Aristolochiae Mollissimae 21 parts, Lignum Pini Nodi 17 parts, Rhizoma Polygonati 17 parts, Rhizoma Cibotii 26 parts, Radix Oenotherae erythrosepalae 23 parts, Cortex Sorbariae Arboreae 8 parts, The Iron Buddha 6 parts, Radix delphinii fargesii 5 parts and 7 parts, Pericarpium Zanthoxyli.
6. according to the arbitrary described pharmaceutical preparation of claim 1-3; it is characterized in that, in described endo-medicine, the ratio of weight and number of each raw medicinal material is: Radix Triplostegiae Grandiflorae 35 parts, Radix et Rhizoma Smilacis Ripariae 15 parts, Radix Et Caulis Acanthopanacis Senticosi 40 parts, Radix polygalae arillatae 23 parts, Herba Origani 21 parts, Radix Jasmini Giraldii 15 parts, Radix seu folium Gaultheriae intermediae 34 parts, Radix et rhizoma smilacinae japonicae 15 parts, 24 parts, Flos Carthami, Rhizoma anemones davidii 10 parts, Radix seu Folium Heliciae cochinchinensis 23 parts, Concha Arcae 12 parts, expectorant medicine 14 parts, Chinese fanpalm seed 11 parts, Gaultheria 23 parts, the Herba Blumeae Laciniatae 29 parts, Rhizoma et radix smilacis santis 13 parts, Herba Aristolochiae Mollissimae 10 parts, Lignum Pini Nodi 6 parts, Rhizoma Polygonati 17 parts, Rhizoma Cibotii 23 parts and Radix Oenotherae erythrosepalae 23 parts;
In described external used medicine, the ratio of weight and number of each raw medicinal material is:
Radix Triplostegiae Grandiflorae 27 parts, Radix Et Caulis Acanthopanacis Senticosi 26 parts, Radix polygalae arillatae 24 parts, Herba Origani 21 parts, Radix seu folium Gaultheriae intermediae 28 parts, Radix et rhizoma smilacinae japonicae 19 parts, 18 parts, Flos Carthami, Rhizoma anemones davidii 12 parts, Radix seu Folium Heliciae cochinchinensis 12 parts, Concha Arcae 12 parts, expectorant medicine 17 parts, Chinese fanpalm seed 11 parts, Gaultheria 33 parts, the Herba Blumeae Laciniatae 27 parts, Rhizoma et radix smilacis santis 20 parts, Herba Aristolochiae Mollissimae 15 parts, Lignum Pini Nodi 14 parts, Rhizoma Polygonati 13 parts, Rhizoma Cibotii 28 parts, Radix Oenotherae erythrosepalae 19 parts, Cortex Sorbariae Arboreae 6 parts, The Iron Buddha 4 parts, Radix delphinii fargesii 7 parts and 3 parts, Pericarpium Zanthoxyli.
7. according to the arbitrary described pharmaceutical preparation of claim 1-6, it is characterized in that, when the dosage form of described endo-medicine is honey refining pill, its preparation method comprises the following steps:
Step 1: first Radix Triplostegiae Grandiflorae, Radix et Rhizoma Smilacis Ripariae, Radix Et Caulis Acanthopanacis Senticosi, Radix polygalae arillatae, Radix seu folium Gaultheriae intermediae, Radix et rhizoma smilacinae japonicae, Concha Arcae were pulverized 180-200 mesh sieve, and obtained powder;
Step 2: get surplus stock medical material again and mix in described ratio, add relative to 83-94% soak with ethanol 1-2 hour of mixture 2-6 times amount, heating extraction 2 times, each 1-1.5 hour, merge extractive liquid, 124-150 order filter, be the ultrafiltration post ultrafiltration of 4400-98000 again through the molecular weight that dams, when ultrafiltrate is evaporated to 65 DEG C, relative density is the extractum of 1.34, becomes component 1;
Step 3: step 2 medicine slag is added 1-3 times amount water soaking 1-2.5 hour, extract 1 time, extraction time is 1.5-2 hour, and thickening filtration is extractum shape, is component 2,
Step 4: said components 1 and component 2 two kinds of extractum are condensed into pasty state, add the powder that step 1 obtains, add Mel and be twisted into pill.
8., according to the arbitrary described pharmaceutical preparation of claim 1-6, it is characterized in that, when the dosage form of described endo-medicine is capsule, its preparation method comprises the following steps:
The first step, first pulverized 180-200 mesh sieve by Radix Triplostegiae Grandiflorae, Radix et Rhizoma Smilacis Ripariae, Radix Et Caulis Acanthopanacis Senticosi, Radix polygalae arillatae, Radix seu folium Gaultheriae intermediae, Radix et rhizoma smilacinae japonicae, Concha Arcae, obtained powder;
Second step, Gaultheria, the Herba Blumeae Laciniatae and Rhizoma et radix smilacis santis are mixed in described ratio, add relative to mixture 2 ~ 5 times amount determining alcohol be 75% ~ 90% alcohol reflux 3 ~ 5 times, each 2 ~ 3 hours, filter respectively, each time filtrate merges, and reclaims ethanol, when being concentrated into 45 DEG C, relative density is the clear paste of 1.30 ~ 1.40, for subsequent use;
3rd step, will remain described raw medicinal material and mix in described ratio, add relative to mixture 8 ~ 10 times of water gagings, boil 3 ~ 5 hours, filter, and when being concentrated into 50 DEG C, relative density is the clear paste of 1.22 ~ 1.30;
4th step, mixed by the powder of the clear paste of second step, the 3rd step and the first step, 60 DEG C ~ 70 DEG C reduced vacuum dryings, get dry extract powder;
5th step, add the mixture relative to dried cream powder described in 100 weight portions subsequently, 5 ~ 7 weight portion carboxymethyl starch sodium, 5 ~ 50 weight starch mix homogeneously, adding 150 ~ 200 weight portion determining alcohols is 80% ~ 90% alcohol granulation, drying, granulate, adds the mixture relative to volatile oil clathrate compound described in 100 weight portions and dried cream powder subsequently, 3 ~ 5 weight portion magnesium stearate, then load in gelatine capsule.
9., according to the arbitrary described pharmaceutical preparation of claim 1-6, it is characterized in that, when the dosage form of described external used medicine is patch, its preparation method comprises the following steps:
The first step, mixes Cortex Sorbariae Arboreae, The Iron Buddha, Radix delphinii fargesii and Pericarpium Zanthoxyli in described ratio, adds the soaking in Chinese liquor 5-7 days relative to mixture 8 ~ 10 times amount 50 degree, and filtering relative density when filtrate being concentrated into 50 DEG C is the clear paste of 1.23 ~ 1.30;
Second step, pulverized 180-200 mesh sieve by Radix Triplostegiae Grandiflorae, Radix et Rhizoma Smilacis Ripariae, Radix Et Caulis Acanthopanacis Senticosi, Radix polygalae arillatae, Radix seu folium Gaultheriae intermediae, Radix et rhizoma smilacinae japonicae, Concha Arcae, obtained powder;
3rd step, soaks 1-2 hour by described surplus stock medical material in described ratio mixing, is then placed in multi-function extractor, and first time decocts 5-10 times that amount of water is medical material, decoct, when being heated to 100 DEG C, start timing, micro-boil 2 hours after, from feed opening filter release medicinal liquid, put in fluid reservoir; Second time decocts, and amount of water is medical material 5-10 times amount, is heated to 100 DEG C, micro-boil 2 hours after, extract medicinal liquid out, merge with the medicinal liquid that decocts of first time; To merge in the decoction liquor suction concentrating under reduced pressure tank of latter 2 times, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, being concentrated into relative density is 1.20, the extractum of temperature to 60 DEG C-70 DEG C, cooling, after ultraviolet radiation sterilizing, the powder mix homogeneously of the clear paste and second step that add the first step obtains mixture, then adds relative to the rubber of 2 times of described mixture sum, the Colophonium of 2 times, mix homogeneously, carry out painting cream, cut off, lid lining, section, namely obtains described patch.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1456224A (en) * | 2003-01-22 | 2003-11-19 | 毛友昌 | Preparation of spur eliminating capsules |
| US20090041857A1 (en) * | 2007-08-07 | 2009-02-12 | Nabob Rx | Analgesic Cream |
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- 2014-12-02 CN CN201410716337.2A patent/CN104474399A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1456224A (en) * | 2003-01-22 | 2003-11-19 | 毛友昌 | Preparation of spur eliminating capsules |
| US20090041857A1 (en) * | 2007-08-07 | 2009-02-12 | Nabob Rx | Analgesic Cream |
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| Title |
|---|
| 周映深，李秉华: "自拟"骨痹灵"临床应用报道", 《中医药研究》 * |
| 赵方平等: "自拟骨刺汤治疗腰椎骨质增生74例疗效观察", 《甘肃中医》 * |
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