CN104474173B - A kind of medicine for treating facioplegia - Google Patents

Abstract

The invention discloses a kind of medicine for treating facioplegia, the medicine is that the medicine can be processed into the formulations such as decoction, tablet, pill, powder, capsule using moxibustion radix astragali, uncaria, Radix Paeoniae Alba, peach kernel, stiff silkworm, safflower, Ligusticum wallichii, earthworm, Angelica sinensis, asarum, rhizoma typhonii, folium artemisiae argyi, scorpio as medicament made of raw material.The present invention defer to the differentiation of disease and it is dialectical be combined principle, treat both principal and secondary aspect of disease, mutually promote curative effect, prescription is rigorous, and the division of labor clearly makes drug effect go directly lesion.Through that should have for many years, for cure rate up to 87%, total effective rate is up to 97%, evident in efficacy, has no toxic side effect.

Description

A kind of medicine for treating facioplegia

Technical field

The invention belongs to dyskinesia field, more particularly to a kind of medicine for treating facioplegia.

Background technology

Facioplegia is a kind of disease common in neurology department, and from the limitation at age, progression of the disease is rapid, serious shadow The normal life of patient is rung.Common sympton is facial paralysis, face spasm, babble, and eyes closed is difficult, with eyes Shed tears, masticatory atonia, dysphagia, slobbers, corners of the mouth leak when drinking water, and during feed, swill is often stranded in the tooth of disease side In volume gap, and there is saliva to be dropped down from sick side, have a stuffy nose, tinnitus, headache, trigeminal neuralgia, toothache caused by facial neuritis.Mesh Before, the main anti-inflammatory of Western medicine, subsides a swelling, and vasodilator drug treatment, such as with hormone, vitamins, such as uses the year of nitric acid scholar, acetic acid can Pine, the drug therapy such as VB12, therapeutic effect is bad, is also easy to produce the resistance to the action of a drug, and side effect is very big, and cure rate is not high, so that long Phase is invalid, can only take stopgap measures, it is impossible to effects a permanent cure, finally leaves sequelae, great stress is brought to patient.

The traditional Chinese medical science thinks that facioplegia belongs to the category of apoplexy, is commonly called as facial paralysis, facial paralysis, wapperijaw wind, the occurrence of this disease master If face experiences ailment said due to cold or exposure, obstruction of collateral caused by windphlegm, channels and collaterals are obstructed, and cause facial qi-blood circulating obstacle, and channels and collaterals, which lose, supports, therefore causes face nerve fiber crops Numbness.Qianzheng San orally taken for curing is generally adopted in the traditional Chinese medical science, and because medication time is grown, curative effect is not high, and effect is undesirable；In addition, test room plaster, Acupuncture is also traditional treatment means, though effective, cycle length, cure rate is low, all undesirable.

The content of the invention

For the prior art, the invention discloses a kind of medicine of brand-new treatment facioplegia, there is therapeutic effect The advantages that good, cure rate height, no sequel.

The medicine of the present invention, is the medicament made of the raw material of following weight proportioning：Moxibustion radix astragali 20 ~ 42, uncaria 10 ~ 30, It is Radix Paeoniae Alba 10 ~ 30, peach kernel 7 ~ 17, stiff silkworm 7 ~ 17, safflower 7 ~ 17, Ligusticum wallichii 7 ~ 17, earthworm 7 ~ 17, Angelica sinensis 6 ~ 15, asarum 3 ~ 10, white attached Son 3 ~ 10, folium artemisiae argyi 3 ~ 10, scorpio 3 ~ 10.

As a kind of preferred embodiment, the weight proportion of each raw material is：Moxibustion radix astragali 25 ~ 36, uncaria 14 ~ 25, Radix Paeoniae Alba 14 ~ 25th, peach kernel 9 ~ 15, stiff silkworm 9 ~ 15, safflower 9 ~ 15, Ligusticum wallichii 9 ~ 15, earthworm 9 ~ 15, Angelica sinensis 8 ~ 12, asarum 5 ~ 8, rhizoma typhonii 5 ~ 8, Chinese mugwort Leaf 4 ~ 8, scorpio 4 ~ 8.

As a kind of preferred embodiment, the weight proportion of each raw material is：Moxibustion radix astragali 30, uncaria 20, Radix Paeoniae Alba 20, peach kernel 12nd, stiff silkworm 12, safflower 12, Ligusticum wallichii 12, earthworm 12, Angelica sinensis 10, asarum 6, rhizoma typhonii 6, folium artemisiae argyi 6, scorpio 6.

Medicinal preparation for oral administration is made in above-mentioned Chinese medicine material according to a conventional method, i.e., the decoction in pharmacy, tablet, pill, Powder, capsule etc..

The specific preparation method of medicine decoction and capsule of the present invention is as follows：

Each bulk pharmaceutical chemicals of above-mentioned weight proportion are weighed, are rinsed well with water, are added water to cook 2 ~ 4 times, decocts add original every time Expect the water of 1.5 ~ 6 times of medicine gross weight, decoct 15 ~ 20 minutes, merge each decocting liquid, the filtered dress bag that removes slag, that is, obtain decoction； Decocting liquid after filtering is concentrated into relative density 1.18 ~ 1.27（50℃）Thick paste, it is dry, be ground into fine powder, load capsule In capsule is made；The customary adjuvant of addition pill agent obtains pill；The customary adjuvant of addition film-making agent obtains tablet；Addition is frozen Dry powder obtains injection.

As a kind of preferred embodiment, each bulk pharmaceutical chemicals of above-mentioned weight proportion can also be rinsed well with water, will removed Various medicines beyond uncaria add water to cook 5 ~ 10 minutes, add uncaria and continue decoction 10 ~ 20 minutes, repeat decoction 3 times, every time The water for adding 1.5 ~ 6 times of bulk pharmaceutical chemicals gross weight is decocted, merges the decocting liquid of 3 times, the filtered dress bag that removes slag, that is, obtain decoction；Incited somebody to action Decocting liquid after filter is concentrated into relative density 1.18 ~ 1.27（50℃）Thick paste, it is dry, be ground into fine powder, be fitted into capsule and make Into capsule.

Moxibustion radix astragali invigorating qi for strengthening superficies, invigorating middle warmer and replenishing QI, promoting pus discharge and tissue regeneration in the present invention；Uncaria The flat liver of heat-clearing, relieving convulsion and spasm, opposite god There is good opsonic action through paralysis, reach suppressing hyperactive liver for calming endogenous wind, dredging collateral with being longer than the scorpio of ceases wind, being good at convergent Radix Paeoniae Alba compatibility Analgesic, giving consideration to both the incidental and fundamental, the optimum efficiency of soft liver yin-nourishing；Peach kernel dissolving stasis promoting circulation of blood, with Angelica sinensis, safflower, Ligusticum wallichii, earthworm compatibility to qi and blood The facioplegia tool of stasis type has a better effect；Stiff silkworm antispastic, calmness, clearing away wind heat, have treatment with uncaria, asarum compatibility The wind-heat illness such as wind-heat twitch, headache due to pathogenic wind-heat, contributes to patient's heart, liver, spleen, lung channel network with rhizoma typhonii, Ligusticum wallichii compatibility Conditioning, plays the effect that numbness is treated in wind-dispelling altogether；Safflower invigorate blood circulation, stasis-dispelling and pain-killing are logical with peach kernel, the power of Ligusticum wallichii dissipating blood stasis with potent drugs, pungent scattered temperature Property it is splendid, reach the effect of dysmenorrhoea dissipates the stasis of blood, blood-breaking；Ligusticum wallichii blood-activating and qi-promoting, wind-expelling pain-stopping, asarum also have expelling wind and clearing away cold Analgesic, sensible effect of Wenfei of drink, and slightly poisonous, Ligusticum wallichii and asarum compatibility play the effect of expelling wind and activating blood flow cold dispelling altogether, plus Ligusticum wallichii pair Liver Channel is nursed one's health, and curative effect plays more preferably；Rhizoma typhonii cold-dispelling, by cold-dampness, Zhi Ching relieve pain, stop convulsion opposite with scorpio compatibility relieve heat Facial paralysis disease has excellent effect in neural paralysis；Folium artemisiae argyi, to three spleen, lung, kidney channels and network vessels regulations, reaches scattered with Radix Paeoniae Alba, Angelica sinensis Cold analgesic effect.Every Chinese medicine, which cooperates, in the present invention coordinates, and mutually promotes curative effect, prescription is rigorous, and the division of labor clearly makes drug effect Through lesion.The present invention reaches enhancing patient's autoimmune function by the dredging to body channels and collaterals, the conditioning of negative and positive actual situation Purpose, makes facioplegia obtain treatment fundamentally.

Drug therapy rheumatic lumbocrural pain pain of the present invention is not only effective, but also can effect a radical cure, and not only takes stopgap measures, but also effects a permanent cure, right The Small side effects of human body, effect far surpass in other/Western medicine.

Embodiment

The embodiment and curative effect of the present invention are described in further detail in conjunction with embodiment.

Embodiment 1

A kind of medicine for treating facioplegia, is the medicament made of the raw material of following weight proportioning：Moxibustion radix astragali 20g, Uncaria 10g, Radix Paeoniae Alba 10g, peach kernel 7g, stiff silkworm 7g, safflower 7g, Ligusticum wallichii 7g, earthworm 7g, Angelica sinensis 6g, asarum 3g, rhizoma typhonii 3g, Chinese mugwort Leaf 3g, scorpio 3g, above-mentioned each bulk pharmaceutical chemicals are rinsed well with water, are added water to cook 2 times, decoct add bulk pharmaceutical chemicals gross weight 6 every time Water again, decocts 20 minutes, merges the decocting liquid of 2 times, the filtered dress bag that removes slag, that is, obtain decoction.

Embodiment 2

A kind of medicine for treating facioplegia, is the medicament made of the raw material of following weight proportioning：Moxibustion radix astragali 42g, It is uncaria 30g, Radix Paeoniae Alba 30g, peach kernel 17g, stiff silkworm 17g, safflower 17g, Ligusticum wallichii 17g, earthworm 17g, Angelica sinensis 15g, asarum 10g, white attached Sub- 10g, folium artemisiae argyi 10g, scorpio 10g, above-mentioned each bulk pharmaceutical chemicals are rinsed well with water, are added water to cook 4 times, decoct add original every time Expect the water of 5 times of medicine gross weight, decoct 18 minutes, merge the decocting liquid of 4 times, the filtered dress bag that removes slag, that is, obtain decoction.

Embodiment 3

A kind of medicine for treating facioplegia, is the medicament made of the raw material of following weight proportioning：Moxibustion radix astragali 25g, Uncaria 14g, Radix Paeoniae Alba 14g, peach kernel 9g, stiff silkworm 9g, safflower 9g, Ligusticum wallichii 9g, earthworm 9g, Angelica sinensis 8g, asarum 5g, rhizoma typhonii 5g, Chinese mugwort Leaf 4g, scorpio 4g, above-mentioned each bulk pharmaceutical chemicals are rinsed well with water, are added water to cook 4 times, decoct add bulk pharmaceutical chemicals gross weight every time 1.5 times of water, decocts 15 minutes, merges the decocting liquid of 4 times, it is filtered remove slag it is concentrated into relative density be 1.27（50℃）It is thick Cream, drying, be ground into fine powder, is fitted into capsule and capsule is made.

Embodiment 4

A kind of medicine for treating facioplegia, is the medicament made of the raw material of following weight proportioning：Moxibustion radix astragali 36g, Uncaria 25g, Radix Paeoniae Alba 25g, peach kernel 15g, stiff silkworm 15g, safflower 15g, Ligusticum wallichii 15g, earthworm 15g, Angelica sinensis 12g, asarum 8g, rhizoma typhonii 8g, folium artemisiae argyi 8g, scorpio 8g, above-mentioned each bulk pharmaceutical chemicals are rinsed well with water, are added water to cook 3 times, and it is total to decoct addition bulk pharmaceutical chemicals every time The water that 3 times of weight, decocts 18 minutes, merges the decocting liquid of 3 times, it is filtered remove slag it is concentrated into relative density be 1.20（50℃）'s Thick paste, drying, be ground into fine powder, and the customary adjuvant of addition pill agent obtains pill.

Embodiment 5

A kind of medicine for treating facioplegia, is the medicament made of the raw material of following weight proportioning：Moxibustion radix astragali 30g, Angelica sinensis 10g, uncaria 20g, peach kernel 12g, stiff silkworm 12g, asarum 6g, Radix Paeoniae Alba 20g, safflower 12g, rhizoma typhonii 6g, Ligusticum wallichii 12g, earthworm 12g, folium artemisiae argyi 6g, scorpio 6g, above-mentioned each bulk pharmaceutical chemicals are rinsed well with water, and the various medicines in addition to uncaria are added water to cook 10 Minute, add uncaria and continue to decoct 10 minutes, repeat to decoct 3 times, decoct the water for adding 4 times of bulk pharmaceutical chemicals gross weight every time, close And the decocting liquid of 3 times, it is filtered remove slag it is concentrated into relative density be 1.25（50℃）Thick paste, it is dry, be ground into fine powder, add The customary adjuvant of film-making agent obtains tablet.

Embodiment 6

A kind of medicine for treating facioplegia, is the medicament made of the raw material of following weight proportioning：Moxibustion radix astragali 30g, Angelica sinensis 10g, uncaria 20g, peach kernel 12g, stiff silkworm 12g, asarum 6g, Radix Paeoniae Alba 20g, safflower 12g, rhizoma typhonii 6g, Ligusticum wallichii 12g, earthworm 12g, folium artemisiae argyi 6g, scorpio 6g, above-mentioned each bulk pharmaceutical chemicals are rinsed well with water, and the various medicines in addition to uncaria are added water to cook 5 points Clock, adds uncaria and continues to decoct 20 minutes, repeat to decoct 3 times, decoct the water for adding 3 times of bulk pharmaceutical chemicals gross weight every time, merge 3 Secondary decocting liquid, it is filtered remove slag it is concentrated into relative density be 1.18（50℃）Thick paste, dry, be ground into fine powder, addition is frozen Dry powder obtains injection.

In order to further investigate the clinical efficacy of drug therapy facioplegia of the present invention, 200 facioplegias are selected Disease has carried out clinical observation on the therapeutic effect.

1. case-data

Case totally 200 is observed, outpatient service and admissions office patient of the patient for certain academy of traditional Chinese medicine, its single-blind randomized is divided into 2 groups for the treatment of group and control group, every group each 100.Age 25-70 Sui in treatment group, average age are 47.5 years old, the course of disease 1 month ~ It is 15 years, 1.2 years average；Age 24-72 Sui in control group, average age are 47.2 years old, and the course of disease 1 month ~ 15 years is 1.1 years average. Two groups are compared in age, the course of disease, coincident with severity degree of condition and adjoint disease etc., are comparable.

2. diagnostic criteria

Facioplegia patient is divided into peripheral facial paralysis and central facial palsy, the former most reason is unknown, with cold, wind Blow, virus infection is related, may be caused by affected part nerve conduction is lacked of proper care, and the latter is complication caused by cerebrovas-cularaccident, performance For sick side surface part histrionic palsy, volume line disappears or shoals, it is impossible to which wrinkle volume is frowned, and palpebral fissure cannot close or dysraphism, examination are closed At the moment, paralysis branch hole ball rotates upward, exposes white sclera, claims bell's phenomenon.Sick side nasolabial groove shoals, ptosis of labial angle, face Cheek is led to strong side, close one's eyes, grinningly, drum cheek, the action failure such as whistle, or cannot complete completely.Eaten because buccinator muscle is paralysed Thing is easily stranded between the tooth cheek of disease side.Lacrimal point turns up with lower eyelid, tear is caused from normal absorption excessive.Such as invade and rouse beam When neural, it may appear that 2/3 dysgeusia before tongue.

3. treatment method.

3.1 treatment group：Tcm therapy is given, takes the decoction or capsule of the present invention, decoction：Every dose of 200mL, daily Morning, take orally for late 2 times, every time 200 mL；Capsule：Every capsule contains traditional Chinese medicine powder 0.12g of the present invention, daily early, evening 2 times, and every time 2 ~ 8；Capsules/tablets/pill：Every capsules/tablets/ball contains traditional Chinese medicine powder 0.12g of the present invention, daily early, evening 2 times, every time 2 ~ 8；Pin Agent：Every contains traditional Chinese medicine powder 0.8g of the present invention, each one daily morning and evening；Pungent, peppery, sour, cold, greasy, wine tea etc. is avoided eating, 15 days are one A course for the treatment of, the general 3-10 course for the treatment of will significantly improve, and dosage can be according to patient age, weight, the class for the disease treated Type and the order of severity etc. make the appropriate adjustments.

3.2 control group：Conventional treatment, such as anti-inflammatory are given, is subsided a swelling, vasodilator drug treatment, such as with hormone, dimension life Element, and coordinate traction treatment and acupuncture and moxibustion treatment to carry out auxiliary treatment, avoid eating pungent, peppery, sour, cold, greasy, wine tea etc..

4. observation index.

4.1 curative effect index patient's subjective symptoms, the symptom pretherapy and post-treatment to patient are recorded respectively, according to criterion of cure, are had Criterion standard judges therapeutic effect.

The general physical examination project of 4.2 safety indexes（Body temperature, breathing, pulse, blood pressure）, blood urine stool routine, darling renal function Check etc., above project is each before medication and after each course for the treatment of to be checked once, observes adverse reaction at any time.

5 criterions of therapeutical effect and treatment results.

5.1 standard references《Clinical disease diagnosis is according to healing improvement standard》It is defined below standard：Criterion of cure is patient Complete symptom disappears, and upper and lower catacleisis is good, facial muscle functional rehabilitation；Effective standard is clearly better for the state of an illness, and volume line recovers, Upper and lower catacleisis strength is weak, and the cry visible slight ptosis of labial angle of Ipsilateral, facial muscle groups contractile motion when laughing at are slightly worse；Null criterion is Symptom and laboratory examination are without substantially changeing.

5.2 two groups of patient's curative effects compare, and are shown in Table 1

By table 1 as it can be seen that in 100 patients for the treatment of group, healing 87, effective 10, invalid 3, total effective rate 97%； In 100 patients of control group, healing 35, effective 23, invalid 42, total effective rate 58%.

1 two groups of patient's curative effects of table compare.

Group	Cure	Effectively	It is invalid	Total effective rate
					Treatment group（100）	87	10	3	97%
Control group（100）	35	23	42	58%

5.3 safety indexes are observed

The general physical examination project of two groups of patients, the inspection of blood urine stool routine, cardiac inspection etc. are equal before and after this clinical observation treatment Without significant change.During observation, two groups do not occur serious adverse events during this clinical observation, pretherapy and post-treatment hepatic and renal function and Blood routine index of correlation is without significant difference.

As it can be seen that the medicine of the present invention can more significantly improve the curative effect of facioplegia than traditional remedies, and it is not present Side effect, patient compliance is good, has actual clinical meaning.

Claims (3)

1. a kind of medicine for treating facioplegia, it is characterised in that it is the medicament made of the raw material of following weight proportioning： Moxibustion radix astragali 20 ~ 42, uncaria 10 ~ 30, Radix Paeoniae Alba 10 ~ 30, peach kernel 7 ~ 17, stiff silkworm 7 ~ 17, safflower 7 ~ 17, Ligusticum wallichii 7 ~ 17, earthworm 7 ~ 17, Angelica sinensis 6 ~ 15, asarum 3 ~ 10, rhizoma typhonii 3 ~ 10, folium artemisiae argyi 3 ~ 10, scorpio 3 ~ 10.

2. the medicine for the treatment of facioplegia as claimed in claim 1, it is characterised in that the weight proportion of wherein each raw material is： Moxibustion radix astragali 25 ~ 36, uncaria 14 ~ 25, Radix Paeoniae Alba 14 ~ 25, peach kernel 9 ~ 15, stiff silkworm 9 ~ 15, safflower 9 ~ 15, Ligusticum wallichii 9 ~ 15, earthworm 9 ~ 15, Angelica sinensis 8 ~ 12, asarum 5 ~ 8, rhizoma typhonii 5 ~ 8, folium artemisiae argyi 4 ~ 8, scorpio 4 ~ 8.

3. the medicine for the treatment of facioplegia as claimed in claim 1, it is characterised in that the weight proportion of wherein each raw material is： Moxibustion radix astragali 30, uncaria 20, Radix Paeoniae Alba 20, peach kernel 12, stiff silkworm 12, safflower 12, Ligusticum wallichii 12, earthworm 12, Angelica sinensis 10, asarum 6, rhizoma typhonii 6th, folium artemisiae argyi 6, scorpio 6.