CN104430425B - A kind of bactericidal composition containing nitre benzene bacterium ester and albendazole - Google Patents
A kind of bactericidal composition containing nitre benzene bacterium ester and albendazole Download PDFInfo
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- CN104430425B CN104430425B CN201410699307.5A CN201410699307A CN104430425B CN 104430425 B CN104430425 B CN 104430425B CN 201410699307 A CN201410699307 A CN 201410699307A CN 104430425 B CN104430425 B CN 104430425B
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- albendazole
- bacterium ester
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Abstract
The invention discloses a kind of bactericidal composition containing nitre benzene bacterium ester and albendazole, including the first active ingredient nitre benzene bacterium ester and the second active ingredient albendazole and conventional auxiliary element, the weight ratio of nitre benzene bacterium ester and albendazole in the composition is 40:1~1:40；Show that bactericidal composition of the present invention has obvious synergistic function through substantial amounts of experiment, to the multiple diseases on Cereal, fruit tree, vegetables, flowers, single dose exclusive use especially is substantially better than to the prevention effect of powdery mildew；Reduce Pesticide use amount simultaneously, reduce use cost, alleviate pollution to environment, delayed the drug-fast generation of pathogen.
Description
Technical field
The present invention relates to pesticide sterilizing composite and its application field, specifically using nitre benzene bacterium ester and albendazole as
Active ingredient bactericidal composition, be mainly used in Cereal, fruit tree, vegetables, on flowers powdery mildew preventing and treating.
Background technology
At present, chemical prevention is still the mostly important means in the plant disease comprehensive regulation, but long-term continuous high
Apply single chemical bactericide dosage, easily cause medicament residual, environmental pollution and pathogen and be also easy to produce resistance to the action of a drug etc.
Problem, the reasonable compounding of chemical bactericide, which has, expands fungicidal spectrum, improves prevention effect, reduces dosage, reduce poisoning, reduce
Remain, delay many advantages, such as germ drug-fast generation, it is seen then that chemical bactericide compounding is to solve the above problems at present most
For one of effective method.
Nitre benzene bacterium ester, belongs to dinitrophenol dinitrophenolate series bactericidal agent, each stage of the pathogen history of life is acted on, by suppressing spore
Son is sprouted, and suppresses fungi respiration, causes cell metabolism disorderly, so that pathogen cell death, in multiple kinds of crops
Powdery mildew have special efficacy.
Rosickyite azoles, also known as albendazole, belong to benzimidazoles derivative, and people is used as always before as disinfectant use in agriculture
Raise medication and treat various enteric bacteria and parasitic infection, there is prevention ＆ protection, interior suction treatment, infiltration conduction, fungicidal spectrum
Extensively, to rice blast, wheat scab, watermelon anthrax, sigatoka, tobacco virus, Powdery Mildew in Tobacco, Chinese cabbage
Downy mildew, watermelon blight etc. have good prevention effect.
The present inventor has made intensive studies to the screening of the compounded formula of nitre benzene bacterium ester and albendazole, sends out unexpectedly
Existing, nitre benzene bacterium ester and albendazole are compounded, and have obvious synergistic function in the range of certain compound proportion,
In actual use, nitre benzene bacterium ester and albendazole compounding use be to the multiple diseases on Cereal, fruit tree, vegetables, flowers,
Especially have excellent prevention effect, after further study, complete the present invention to powdery mildew.
The content of the invention
It is an object of the invention to provide a kind of synergistic function is obvious, to white powder on Cereal, fruit tree, vegetables, flowers
The bactericidal composition that the prevention effect of disease is outstanding, cost is low, safety and environmental protection, resistance risk are low.
Technical solution of the present invention：Using nitre benzene bacterium ester and albendazole as active ingredient, the weight of nitre benzene bacterium ester and albendazole
Amount is than being 40:1~1:40, the percentage by weight of nitre benzene bacterium ester and albendazole weight summation in bactericidal composition be 1%~
85%, remaining is to allow to use and acceptable auxiliary element in agricultural chemicals.
Bactericidal composition of the present invention can be prepared into by selecting suitable pesticidal preparations auxiliary element and be adapted to agriculturally make
A variety of application forms, relatively good formulation have suspending agent, micro-capsule suspension, aqueous emulsion, microemulsion, water dispersible granules,
Wettable powder and ultra low volume liquids.
Described auxiliary element is solvent, cosolvent, emulsifying agent, wetting agent, dispersant, stabilizer, antifreezing agent, thickening
Agent, binding agent, disintegrant, defoamer, bleeding agent, synergist, cyst material, pH adjusting agent and filler etc., all it is pesticidal preparations
In commonly use or allow the composition used, be not particularly limited, specific composition and dosage are according to recipe requirements by simply testing
It is determined that.
The production technology of the various application forms of described bactericidal composition belongs to existing known technology, no longer superfluous herein
State.
Bactericidal composition provided by the invention, early stage should occur in disease in application or disease early period of origination uses, lead to
Used frequently with the method for spraying, technology can also be used using other agriculturally applied as needed.
Compared with prior art, the advantage of the invention is that：
1st, two kinds of active ingredient compoundings of nitre benzene bacterium ester and albendazole, preventive effect and single dose obvious with synergistic function
Compared to significantly improving, reduce Pesticide use amount, reduce use cost, Environmental compatibility is good；
2nd, two kinds of active ingredient compoundings of nitre benzene bacterium ester and albendazole, active ingredient mechanism of action is different, and action site increases
Add, be advantageous to overcome and delay the drug-fast generation of germ.
Embodiment
Essence for a better understanding of the present invention, present disclosure is described further with reference to embodiment,
But limitation of the present invention can not be considered as, it is as described below to be only used for explaining the present invention, for without departing from spirit of the invention and principle
Modification, replacement or the improvement made, belong to the scope of protection of present invention.
Each component percentage composition is weight percentage in following examples.
Example of formulations 1：20% nitre benzene bacterium ester albendazole ultra low volume liquids
Nitre benzene bacterium ester 2%, albendazole 18%, N,N-dimethylformamide 10%, cyclohexanone 5%, tripropylene glycol butyl ether
5%th, castor oil polyoxyethylene ether 5%, calcium dodecyl benzene sulfonate 5%, azone 2%, soybean oil complements to 100%.Will be above-mentioned
After active ingredient is dissolved with stirring solvent, emulsifying agent, wetting agent and bleeding agent are added, is thoroughly mixed uniformly, you can system
Obtain 20% nitre benzene bacterium ester albendazole ultra low volume liquids.
Example of formulations 2：30% nitre benzene bacterium ester albendazole suspending agent
Nitre benzene bacterium ester 12%, albendazole 18%, phenethyl phenol polyoxyethylene groups ether phosphate 10%,
TERSPERSE2500 5%, sodium methylene bis-naphthalene sulfonate 5%, polyethylene glycol 3%, xanthans 1%, dimethyl silicone polymer breast
Liquid 0.1%, sodium benzoate 0.3%, deionized water supplies 100%.By above-mentioned active ingredient, wetting agent, dispersant, antifreezing agent,
Thickener, defoamer and preservative are the high dispersive that is formed in water-medium, steady through high speed shear is scattered, is sanded in sand mill
Fixed suspension system, you can 30% nitre benzene bacterium ester albendazole suspending agent is made.
Example of formulations 3：35% nitre benzene bacterium ester albendazole aqueous emulsion
Nitre benzene bacterium ester 30%, albendazole 5%, DMF 5%, solvent naphtha 15%, phenethyl phenol polyoxyethylene polyoxypropylene
Ether 10%, APES sulfosuccinate 5%, aerosol-OT salt 5%, epoxychloropropane 1%,
Sodium benzoate 0.3%, glycerine 1%, deionized water supplies 100%.By above-mentioned active ingredient, solvent, emulsifying agent, dispersant,
Stabilizer and preservative are mixed to form oil phase, and antifreezing agent dissolves in water forms aqueous phase, slowly oil phase under cutter effect
Add in aqueous phase, and continue shearing about 30 minutes, 35% nitre benzene bacterium ester albendazole aqueous emulsion is made.
Example of formulations 4：40% nitre benzene bacterium ester albendazole microemulsion
Nitre benzene bacterium ester 10%, albendazole 30%, DMF 5%, heavy aromatics naphtha Solvesso200 15%, phenethyl
It is phenol polyethenoxy polyethenoxy ether 10%, APES sulfosuccinate 5%, triphenyl phosphite 2%, organic
Silicon 1%, thiophene ketone 2%, propane diols 1%, deionized water supplies 100%.Active ingredient is completely dissolved with solvent, then added
Emulsifying agent, stabilizer, bleeding agent, synergist and antifreezing agent are well mixed, and are eventually adding deionized water, after being sufficiently stirred, you can
40% nitre benzene bacterium ester albendazole microemulsion is made.
Example of formulations 5：80% nitre benzene bacterium ester albendazole water dispersible granules
Nitre benzene bacterium ester 2%, albendazole 78%, calcium dodecyl benzene sulfonate 5%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 3%,
Lignosulfonates 2%, ammonium sulfate 2%, glucose 1%, attapulgite supplies 100%.By above-mentioned active ingredient, wetting agent,
Dispersant, disintegrant, binding agent and filler are well mixed, and are crushed with micro jet, through mediating, then add fluid bed
It is granulated, dried, sieved in granulating and drying machine, you can 80% nitre benzene bacterium ester albendazole water dispersible granules is made.
Example of formulations 6：70% nitre benzene bacterium ester albendazole wettable powder
Nitre benzene bacterium ester 65%, albendazole 5%, neopelex 10%, spaonin powder 5%, fatty acid glyceride
APEO 5%, white carbon 2%, kaolin supplies 100%.By above-mentioned by active ingredient, wetting agent, dispersant and filler
Mix, be well mixed again through air-flow crushing after mechanical crushing, you can 70% nitre benzene bacterium ester albendazole wettable powder is made
Agent.
Example of formulations 7：10% nitre benzene bacterium ester albendazole micro-capsule suspension
Nitre benzene bacterium ester 5%, albendazole 5%, methyl diphenylene diisocyanate 15%, glycerine 1%, solvent naphtha S-
200 10%, ethyl acetate 5%, NPE 5%, polymeric carboxylic salt 3%, sodium lignin sulfonate 3%, go from
Sub- water complements to 100%.Above-mentioned active ingredient, macromolecule cyst material, solvent are mixed, makes to be dissolved into homogeneous oil phase, is cutting
Under tangent condition, by oil phase be added to containing emulsifying agent, dispersant aqueous phase solution in, add hydrochloric acid-potassium chloride buffer solution
It is 7.5 to adjust pH value, and surplus is supplied with deionized water, and two kinds of materials react in oil-water interfaces, forms high score ascus wall, system
Obtain 10% nitre benzene bacterium ester albendazole micro-capsule suspension.
Assays Example 1：The indoor joint toxicity measuring of nitre benzene bacterium ester and albendazole to powdery mildew of cucumber
Subjects：Cucumber powdery mildew's pathogen sphaerotheca fuliginea.
Test method：With reference to《People's Republic of China's agricultural chemicals indoor biologicals of agricultural industry criteria NY/T1156.11-2008
The part of determination test criterion bactericide the 11st：Prevent and treat cucurbits powdery mildew experiment pot-culture method》.Single dose and each Mixed Pharmacy are set first
Put 5 various concentrations gradients (preventive effect is set in the range of 5%~90% by geometric progression).With added with a small amount of surfactant
The pure water of (Tween 80), the Fresh spores for taking and covering with Powdery Mildew cucumber leaves are washed, are filtered with double gauze, spore is made
Concentration is 1 × 105The suspension of individual spore/milliliter, it is standby.3 basins, 4 repetitions are often handled, and is set containing only solvent and surface-active
Agent and do not contain effect composition processing make blank control.After being inoculated with 24h with spore suspension, decoction is uniformly sprayed in blade face extremely
All wettings, thermostatic chamber is moved to after decoction natural air drying, is cultivated 7 days~10 days under conditions of 20~24 DEG C of temperature.Treat sky
When compareing disease leaf rate in vain and reaching more than 80%, incidence is managed in classification investigation everywhere, often handles at least 30 leaves of investigation, classification mark
Standard is：
0 grade：It is disease-free；
1 grade：Lesion area accounts for less than the 5% of full wafer leaf area；
3 grades：Lesion area accounts for the 6%~15% of full wafer leaf area；
5 grades：Lesion area accounts for the 16%~25% of full wafer leaf area；
7 grades：Lesion area accounts for the 26%~50% of full wafer leaf area；
9 grades：Lesion area accounts for the 50%~75% of full wafer leaf area；
11 grades：Lesion area accounts for more than the 75% of full wafer leaf area.
Computational methods：
Disease index=[∑ (the sick numbers of sheets at different levels × relative value of series)/(investigation total leaf number × 11)] × 100
Prevention effect (%)=[(control disease index-processing disease index)/control disease index] × 100
By the linear regression analysis between the probit value of preventive effect and the logarithm value of series concentration, the EC of each medicament is obtained50
Value, the co-toxicity coefficient (CTC) of mixture is calculated with the abundant methods of Sun Yun, activity of the reagent agent to germ is evaluated with this.Co-toxicity coefficient
(CTC) >=120, synergistic effect is shown as；Co-toxicity coefficient (CTC)≤80, shows as antagonism；80 ＜ co-toxicity coefficients (CTC)
＜ 120, shows as summation action.
The indoor joint toxicity measuring result of table 1, nitre benzene bacterium ester and albendazole to powdery mildew of cucumber
As shown in Table 1, nitre benzene bacterium ester and albendazole are 40:1~1:When being compounded in the range of 40 (by weight), poison is altogether
Number (CTC) is all higher than 120, illustrates to show synergistic function to powdery mildew of cucumber, it is seen that nitre benzene bacterium ester is answered with albendazole
With with reasonability and feasibility.
Assays Example 2：Prevent and treat the field control effectiveness test of powdery mildew of cucumber
Test medicine：30% albendazole nitre benzene bacterium ester suspending agent (nitre benzene bacterium ester 12%：Albendazole 18%)
Comparison medicament：10% albendazole suspending agent, 36% nitre benzene bacterium emulsifiable concentrate
Dispenser period：In early stage dispenser once, it is spaced that dispenser is once again 10 days.
Application method：It is watered even spraying.
Result of the test is shown in Table 2；As can be seen from the test results, 30% albendazole nitre benzene bacterium ester suspending agent of the invention
To be significantly better than 10% albendazole suspending agent using the 250-300 grams/ha of prevention effect to powdery mildew of cucumber of active ingredient
It is used alone with 36% nitre benzene bacterium emulsifiable concentrate, preventive effect does not find the compounding up to more than 80% during pilot survey
Medicament produces poisoning to cucumber.
Table 2,30% albendazole nitre benzene bacterium ester suspending agent are to the field control effectiveness test result of powdery mildew of cucumber
Assays Example 3：Prevent and treat the field control effectiveness test of wheat powdery mildew
Test medicine：40% nitre benzene bacterium ester albendazole microemulsion (nitre benzene bacterium ester 10%：Albendazole 30%)
Comparison medicament：10% albendazole suspending agent, 36% nitre benzene bacterium emulsifiable concentrate
Dispenser period：In early stage dispenser once, it is spaced that dispenser is once again 10 days.
Application method：It is watered even spraying.
Result of the test is shown in Table 3；As can be seen from the test results, 40% nitre benzene bacterium ester albendazole microemulsion of the invention
To be significantly better than 10% albendazole suspending agent using the 250-300 grams/ha of prevention effect to wheat powdery mildew of active ingredient
It is used alone with 36% nitre benzene bacterium emulsifiable concentrate, preventive effect does not find the compounding up to more than 80% during pilot survey
Medicament produces poisoning to wheat.
Table 3,40% nitre benzene bacterium ester albendazole microemulsion are to the field control effectiveness test result of wheat powdery mildew
Assays Example 4：Prevent and treat the field control effectiveness test of apple mildew
Test medicine：35% nitre benzene bacterium ester albendazole aqueous emulsion (nitre benzene bacterium ester 30%：Albendazole 5%)
Comparison medicament：10% albendazole suspending agent, 36% nitre benzene bacterium emulsifiable concentrate
Dispenser period：In early stage dispenser once, it is spaced that dispenser is once again 10 days.
Application method：It is watered even spraying.
Result of the test is shown in Table 4；As can be seen from the test results, 35% nitre benzene bacterium ester albendazole aqueous emulsion of the invention
To be significantly better than 10% albendazole suspending agent using the 165-210 grams/ha of prevention effect to apple mildew of active ingredient
It is used alone with 36% nitre benzene bacterium emulsifiable concentrate, preventive effect does not find the compounding up to more than 80% during pilot survey
Medicament produces poisoning to apple.
Table 4,35% nitre benzene bacterium ester albendazole aqueous emulsion are to the field control effectiveness test result of apple mildew
In summary, the present invention is using the bactericidal composition of two kinds of active ingredient compoundings of nitre benzene bacterium ester and albendazole, tool
There is obvious synergistic function, compared with existing unitary agent, prevention effect significantly improves, and to crop safety, is worth
Popularization and application in agricultural production.
Claims (4)
- A kind of 1. bactericidal composition containing nitre benzene bacterium ester and albendazole, it is characterised in that：Active ingredient be nitre benzene bacterium ester and The quality parts ratio of albendazole, nitre benzene bacterium ester and albendazole is 40:1~1:40, nitre benzene bacterium ester and albendazole are being sterilized Total mass fraction percentage composition in composition is 1%~85%, remaining be allow to use in agricultural chemicals and acceptable auxiliary into Point.
- A kind of 2. bactericidal composition containing nitre benzene bacterium ester and albendazole according to claim 1, it is characterised in that：Institute Stating bactericidal composition formulation is suspending agent, micro-capsule suspension, aqueous emulsion, microemulsion, water dispersible granules, wettable powder and surpasses One kind in low capacity liquor.
- 3. a kind of bactericidal composition containing nitre benzene bacterium ester and albendazole described in claim 1 is in preventing and treating crop powdery mildew Purposes.
- 4. a kind of bactericidal composition containing nitre benzene bacterium ester and albendazole according to claim 3 is in preventing and treating crop white powder The purposes of disease, it is characterised in that：Described crop is Cereal, fruit tree, vegetables or flowers.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1074085A (en) * | 1992-09-19 | 1993-07-14 | 贵州道元科技公司 | A kind of compound method of disinfectant use in agriculture |
| EP2014167A1 (en) * | 2007-07-13 | 2009-01-14 | Bayer CropScience AG | Active compound combinations |
| CN103931623A (en) * | 2014-04-30 | 2014-07-23 | 海利尔药业集团股份有限公司 | Bactericidal composition containing meptyldinocap and prothioconazole |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1074085A (en) * | 1992-09-19 | 1993-07-14 | 贵州道元科技公司 | A kind of compound method of disinfectant use in agriculture |
| EP2014167A1 (en) * | 2007-07-13 | 2009-01-14 | Bayer CropScience AG | Active compound combinations |
| CN103931623A (en) * | 2014-04-30 | 2014-07-23 | 海利尔药业集团股份有限公司 | Bactericidal composition containing meptyldinocap and prothioconazole |
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