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CN104397695B - A kind of sea cucumber lycopene tea polyphenol tablet and preparation method thereof - Google Patents

A kind of sea cucumber lycopene tea polyphenol tablet and preparation method thereof Download PDF

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Publication number
CN104397695B
CN104397695B CN201410701464.5A CN201410701464A CN104397695B CN 104397695 B CN104397695 B CN 104397695B CN 201410701464 A CN201410701464 A CN 201410701464A CN 104397695 B CN104397695 B CN 104397695B
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powder
lycopene
sea cucumber
tea polyphenol
coating
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CN104397695A (en
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单丽辉
饶大毅
郑立勇
段人钰
姜颜
石佳
马潘蕾
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SHANDONG WEINILAI BIOTECHNOLOGY Co Ltd
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SHANDONG WEINILAI BIOTECHNOLOGY Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
    • A23P20/10—Coating with edible coatings, e.g. with oils or fats
    • A23P20/15—Apparatus or processes for coating with liquid or semi-liquid products
    • A23P20/18—Apparatus or processes for coating with liquid or semi-liquid products by spray-coating, fluidised-bed coating or coating by casting
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
    • A23L17/70—Comminuted, e.g. emulsified, fish products; Processed products therefrom such as pastes, reformed or compressed products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Polymers & Plastics (AREA)
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  • Marine Sciences & Fisheries (AREA)
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  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to food processing technology field, also relate to Medicines and Health Product technical field simultaneously, specifically a kind of sea cucumber lycopene tea polyphenol tablet, raw material proportioning is by weight: lycopene powder 14-17 part that content is 6%, tea polyphenol powder 5-7 part that content is 80%, holothurian freeze-dried powder 45-55 part, microcrystal cellulose powder 30-35 part, sodium carboxymethyl starch 5-8 part, dolomol 0-2 part, coating powder 2-4 part. Compared with prior art, the present invention has the effects such as the immunity of adjusting, antifatigue, can improve body disease resistance ability, regains one's strength fast and energy, and instant, is senior marine health food of new generation.

Description

A kind of sea cucumber lycopene tea polyphenol tablet and preparation method thereof
Technical field
The present invention relates to food processing technology field, also relate to Medicines and Health Product technical field simultaneously.
Background technology
Sea cucumber is the superfine product in marine organisms, nutritive value is very high, be rich in more than the 50 kind of composition useful to human body, wherein protein content is up to 55% and not containing cholesterol, also contain in addition holothurin, selenka, sashimi mucopolysaccharide, chondroitin sulfate isoreactivity composition, there is tonifying kidney and benefiting sperm, the strong sun of enriching yin, nourishing blood for moistening dryness, the menstruation regulating labor of dispelling, nourishing the fetus profit product waits tonifying both YIN and YANG effect, can improve memory, strengthen body immunity, antiviral, anti-ageing, reducing blood lipid, reparative regeneration, the very typical high protein of one, low fat, the healthy food of low cholesterol, have the laudatory title of marine " nutrition treasure-house ".
The processing method of tradition sea cucumber dry product is not only coarse but also complex process is loaded down with trivial details, conventionally through pickled, roasting ginseng, mix ash, dry and make, operation is many, cycle is long, power consumption is large, running cost is high, a large amount of beneficiating ingredients lose along with the loss of exhausted water, and edible very inconvenient, it is longer that water is sent out the time, also easily there is crust be full of cracks, fat oxidation, the situations such as product surface variable color, cause sea cucumber to lose original local flavor, and the dehydration of freeze-drying sea cucumber thoroughly, product just can be preserved more than 5 years at normal temperatures without any anticorrisive agent, and retain greatly the active component in sea cucumber, added value is higher, more and more be subject to people's favor.
Lycopene is a kind of natural colouring matter contained in plant. Mainly be present in the ripening fruits of plant of Solanaceae tomato. It is one of found powerful antioxidant in natural plant at present, have powerful removing free radical ability, human body had to superior physiological regulation function, can effectively preventing because of aging, the various diseases that immunity degradation causes, has the title of " plant gold ".
Tea Polyphenols is the general name of Polyphenols of Tea. Comprise flavanol compound, anthocyanin class, flavonoids, flavonols and phenolic acid class etc., be mainly catechin, account for 60-80%, there is removing toxic substances, radioresistance, the anti-oxidant and effect of removing free radical, can prevent and treat cardiovascular and cerebrovascular disease, improve comprehensive immunity, in advance anti-aging, remove halitosis, aid digestion, beauty and skin care, its oxidation resistance is 4-6 times of BHA, the 6-7 of VE doubly, and consumption seldom can play a role, and there is no the genotoxic potential of synthetic, be described as by health and medical circle " radiation jinx ".
The absorption of sea cucumber nutrient composition is mainly taking tonic as main at present, in addition the restriction of cooking methods causes utilization rate deficiency, cause a lot of nutrient loss, publication number is that the Chinese invention patent of CN103445168A discloses a kind of " compounding sea ginseng grains chewable tablets and preparation method thereof " it is to be made up of the raw material of following parts by weight: sea cucumber 50-80, pleurotus eryngii 5-30, mushroom 5-20, glasswort 2-10, auxiliary material 5-30. Take, carry, transport all more convenient, but its sea cucumber obtains the granular sea cucumber of 2-10 order after pulverizing, sieving, and absorption of human body and utilization rate are not high, are as good as with traditional eating method.
Publication number is that the Chinese invention patent of 102302614B discloses " a kind of compound sea-cucumber tea-polyphenol capsules and preparation method thereof ", its concrete steps are: (1), by fresh and alive sea cucumbers through cleaning, be dried, be ground into sea cucumber powder, grinding particle size is 200 μ m-100nm; (2) get purity >=90w%, granularity is by the tea polyphenol powder in 80-100 mesh sieve hole; (3) by sea cucumber powder: tea polyphenol powder is according to mass ratio 1.0: 0.5-1.0 fully mixes; (4) step (3) being obtained to mixture, to carry out seminal vesicle filling, every capsule 0.2-0.6g. Although this invention may have the effect of prevention and treatment high fat of blood illness, owing to having experienced convection drying process in its Holothurian machining process, the original active ingredient of sea cucumber may partly run off, and the physiological regulation function of human body is reduced. Raw material is directly mixed to glue capsule and easily cause that content is irregular, loading amount is inaccurate, sea cucumber taste is covered is completely difficult to the concrete composition of perception, and the inconvenience of swallowing of this formulation, palatability is poor, and single antioxidant for clearing human free radical ability is not as composite antioxidant.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, provide one to contain holothurian freeze-dried powder, lycopene, Tea Polyphenols, the health food of comprehensive nutrition, prominent function.
In order to realize the technical scheme that object of the present invention adopts be:
A kind of sea cucumber lycopene tea polyphenol tablet, raw material proportioning is by weight: lycopene powder 14-17 part that content is 6%, content is tea polyphenol powder 5-7 part of 80%, holothurian freeze-dried powder 45-55 part, microcrystal cellulose powder 30-35 part, sodium carboxymethyl starch 5-8 part, dolomol 0-1 part, coating powder 2-4 part.
Because DHA content in sea cucumber is very high, DHA has the immunity of enhancing, promotes the effect such as children's brain development and pre-anti-cancer, but due to easily oxidized and limited greatly the performance of its effect. The present invention adopts two kinds of high antioxidant compositions is added in freeze-drying sea cucumber powder, and the synergy of natural composite antioxidant has retained the nutritional labeling of sea cucumber to greatest extent, has improved the health-care efficacy of sea cucumber. Freeze-drying sea cucumber powder, lycopene powder, tea polyphenol powder health-care effect and product quality the best in the claimed ratio range of the present invention; exceed or be less than this scope and easily occur that the antioxidant effect that the situations such as hardness is not good enough, color and luster is poor, mouthfeel is jerky and lycopene powder and tea polyphenol powder are used in conjunction with is better than wherein any single kind, auxiliary reducing blood lipid, improve immunity prominent function the health-care effect of product.
A preparation method for sea cucumber lycopene tea polyphenol tablet, comprises following steps:
1) raw material preparation: fresh sea cucumber gill and rinse well with clear water after carry out high temperature blanching, temperature is at 65-70 DEG C, time is no more than 6 minutes, then steeps and sends out, and after 24 hours, takes out and carries out vacuum freeze drying, fresh apostichopus japonicus selenka is chilled to rapidly to-40 DEG C in freeze-drying cabin, under vacuum state, by regulating temperature and pressure, progressively heat up and make ice directly become steam, time is 50 hours, obtains freeze-drying sea cucumber; After the coarse crushing of freeze-drying sea cucumber, cross the Universalpulverizer of 80 mesh sieves and pulverize, obtain holothurian freeze-dried powder; Lycopene powder, tea polyphenol powder, microcrystal cellulose powder, sodium carboxymethyl starch are crossed respectively 80 mesh sieves;
The present invention adopts fresh sea cucumber to process through vacuum freeze drying; effectively protected the stability of sea cucumber active ingredient, and after dry, form is loose, water content is low; not vulnerable to pollution; extend the shelf-life, raw material quick-recovery biologically active soon after using freeze-drying sea cucumber powder to add water, the sea cucumber tablet of making utilizes state-of-the-art sea cucumber crushing technology; sea cucumber is crushed to 80 to 120 object sizes; directly, through cell membrane, absorptivity improves greatly, and dissolution rate is also better.
2) mix: holothurian freeze-dried powder, lycopene powder, tea polyphenol powder, microcrystal cellulose powder, sodium carboxymethyl starch are placed in to three-dimensional motion mixer mixing 20min, obtain the mixed powder of color and luster uniformity;
3) granulation, dry, whole grain: mixed powder is poured into and granulated in pot, in mixed powder, add the ethanolic solution of concentration 20% to utilize the wet softwood processed of wet mixing pelletizer high-speed stirred mixing, obtain wet granular; Wet granular enters whole grain in pelletizing machine, makes granular size more even, then it is dry that wet granular is put into HighefficientFluidbeddrier, and temperature is 55-65 DEG C, after dry materials, takes out and obtains dry particle;
4) dry particle layering: dry particle is poured in shaking screen and shaken layering, and the superiors are for being greater than 20 order particles, and middle level is 20-40 order particle, and orlop is for being less than 40 object particles; Collect 20-40 order particle for subsequent use;
5) compressing tablet: dry 20-40 order particle, dolomol are placed in to three-dimensional motion mixer mixing 5min, obtain hybrid particles; Hybrid particles is put into rotary tablet machine compressing tablet, and trimmer is heavily 0.6g/ sheet, and removes residual, useless sheet, obtains plain sheet;
In process, freeze-drying sea cucumber powder and other raw material stickiness are larger, and wet granulation difficulty increases; Proportion is lighter, in flakes difficulty. The present invention adopts and adds 20% ethanolic solution can make epigranular disperse, and reduces balling-up and wastage of material loss. In the process of compressing tablet under the prerequisite that does not reduce freeze-drying sea cucumber powder ratio through experimental study with great concentration reasonable in design raw material proportioning, both ensured the quality requirement of product, promote again oxidation resistance, tablet stripping degree under this formula, granular size and pressure condition in blocks and absorption simultaneously better, obtains qualitative leap technically.
6) preparation of coating solution: get 95% edible alcohol, adding purified water, to be configured to concentration be 70% ethanolic solution, pours into and stir in heat insulation tank, getting coating powder, slowly to add concentration be in 70% ethanolic solution, cover lid, stir about 1 hour, stir, be configured to 8% coating solution, for subsequent use;
7) film coating: start high-efficiency coating machine, opening angle seat valve, air draft and hot blast carry out preheating, make the temperature in coating drum reach 45-50 DEG C, pour the plain sheet weighing up into coating drum after negative pressure and temperature stabilization; The coating solution preparing is poured in heat insulation tank, and preheating 5 minutes, opens spraying system, regulates atomizing pressure at 0.15MPa, and spray gun pressure, at 0.8-1.0MPa, starts main frame in starting peristaltic pump, and homogenate is carried out in the uninterrupted running of cylinder is heated evenly label; Adjust rotating speed and the slurry adjuster of peristaltic pump, use spray gun even spraying in the plain sheet surface of rotating, 55-65 DEG C of heated-air drying; After dressing completes, stop whitewashing, close hot blast, treat that outward appearance is bright and clean, color and luster is even, after label is cooling, closes homogenate and air draft, obtains qualified coating tablet, is to be sea cucumber lycopene tea polyphenol tablet.
Further, described coating powder is hydroxypropyl methylcellulose or glyceryl triacetate.
Further, described lycopene powder is produced by natural microbial fermentation method. The lycopene that adopts natural microbial fermentation method to produce, avoids the residual and omnidistance temperature of organic solvent to be controlled in 60 DEG C, ensures preferably the stability of lycopene, has advantages of that quality safety, prepared using degree are high.
Compared with prior art, the present invention is combined with oxidation resistant lycopene and Tea Polyphenols, has better improved the stability of readily oxidizable substance. The Product Green, pure natural, low fat, the low cholesterol that make, containing anticorrisive agent, not containing excitant, there is the effects such as the immunity of adjusting, antifatigue, can improve body disease resistance ability, regain one's strength fast and energy, instant is senior ocean of new generation green health care food.
Detailed description of the invention
One, below in conjunction with concrete example, the present invention is described in further detail.
Embodiment 1:
Get the raw materials ready: the lycopene powder 17kg that content is 6%, the tea polyphenol powder 7kg that content is 80%, holothurian freeze-dried powder 55kg, microcrystal cellulose powder 35kg, sodium carboxymethyl starch 8kg, dolomol 1kg, coating powder 4kg.
The allotment of raw material: fresh sea cucumber gill and rinse well with clear water after carry out high temperature blanching, temperature is at 65-70 DEG C, time is no more than 6 minutes, then steep and send out, after 24 hours, take out and carry out vacuum freeze drying, fresh apostichopus japonicus selenka is chilled to rapidly to-40 DEG C in freeze-drying cabin, under vacuum state, by regulating temperature and pressure, progressively to heat up and make ice directly become steam, the time is 50 hours.
The Universalpulverizer of crossing 80 mesh sieves after the coarse crushing of standard compliant freeze-drying sea cucumber is pulverized, obtained holothurian freeze-dried powder. Lycopene powder, tea polyphenol powder, microcrystalline cellulose, sodium carboxymethyl starch remove external packing and enter clean area, cross respectively 80 mesh sieves.
Mix: holothurian freeze-dried powder, lycopene, Tea Polyphenols, microcrystalline cellulose, sodium carboxymethyl starch are placed in to three-dimensional motion mixer mixing 20min, obtain the mixed powder of color and luster uniformity.
Granulation, dry, whole grain: mixed powder is poured into and granulated in pot, in mixed powder, add the ethanolic solution of concentration 20% to utilize two minutes wet softwoods processed of wet mixing pelletizer high-speed stirred mixing, obtain wet granular. Wet granular enters whole grain in pelletizing machine, makes granular size more even, then it is dry that wet granular is put into HighefficientFluidbeddrier, and temperature is 55 DEG C, and be 30min drying time, and water content is taken out to obtain dry particle lower than 5% time.
Dry particle layering: dry particle is poured in shaking screen and shaken layering, and the superiors are for being greater than 20 order particles, and middle level is 20-40 order particle, and orlop is for being less than 40 object particles. Collect 20-40 order particle for subsequent use.
Compressing tablet: 20-40 order particle, dolomol are placed in respectively to three-dimensional motion mixer mixing 5min, obtain hybrid particles; Each layer of hybrid particles put into respectively to rotary tablet machine compressing tablet, and trimmer is heavily 0.6g/ sheet, compressing tablet, and remove residual, useless sheet, obtain plain sheet.
The preparation of coating solution: get 95% edible alcohol, adding purified water, to be configured to concentration be 70% ethanolic solution, pouring electrical heating into stirs in heat insulation tank, getting coating powder, slowly to add concentration be in 70% ethanolic solution, cover lid, stir about 1 hour, stirs, be configured to 8% coating solution, for subsequent use.
Film coating: start high-efficiency coating machine, open steam valve, air draft and hot blast, make the temperature in coating pan reach 45-50 DEG C, the plain sheet weighing up is poured into and carried out homogenate in coating pan label is heated evenly; Adjust rotating speed and the slurry adjuster of peristaltic pump, start spray gun even spraying in the plain sheet surface of rotating, 55-65 DEG C of heated-air drying. After dressing completes, stop whitewashing, close hot blast, treat that outward appearance is bright and clean, color and luster is even, after label is cooling, closes homogenate and air draft, obtains qualified coating tablet, is to be a kind of sea cucumber lycopene tea polyphenol tablet.
Embodiment 2:
Other are with embodiment 1, only: lycopene powder 14kg, tea polyphenol powder 5kg, holothurian freeze-dried powder 45kg, microcrystal cellulose powder 30kg, sodium carboxymethyl starch 5kg, dolomol 0kg, coating powder 2kg.
Embodiment 3:
Other are with embodiment 1, only: lycopene powder 15kg, tea polyphenol powder 6kg, holothurian freeze-dried powder 50kg, microcrystal cellulose powder 33kg, sodium carboxymethyl starch 7kg, dolomol 0.5kg, coating powder 3kg.
Embodiment 4:
Other are with embodiment 1, only: lycopene powder 16kg, tea polyphenol powder 5.5kg, holothurian freeze-dried powder 47kg, microcrystal cellulose powder 32kg, sodium carboxymethyl starch 6kg, dolomol 0.2kg, coating powder 3.3kg.
Embodiment 5:
Other are with embodiment 1, only: lycopene powder 16kg, tea polyphenol powder 5.8kg, holothurian freeze-dried powder 49kg, microcrystal cellulose powder 31kg, sodium carboxymethyl starch 6.8kg, dolomol 0.8kg, coating powder 2.7kg.
Comparative example 1, sea cucumber lycopene sheet:
Other are with embodiment 1, only: lycopene powder 34kg, tea polyphenol powder 0kg.
Comparative example 2, sea cucumber tea polyphenol tablet:
Other are with embodiment 1, only: lycopene powder 0kg, tea polyphenol powder 14kg.
Two, mouse function test.
1. the impact of lycopene tea polyphenol tablet on Mouse Weight
Sea cucumber lycopene tea polyphenol tablet prepared by sample: embodiment 1.
Animal used as test: select the 18-22g Kunming kind of Beijing HFK Bio-Technology Co., Ltd.'s breeding to clean 48 of level female mices, be divided into 4 groups, 12 every group. Raise the SPF of the health food inspection center level animal housing in College of Applied Arts & Sciences of BJ Union University. Animal used as test occupancy permit number: SYXK(capital) 2012-0031.
Basal feed is purchased from Beijing HFK Bio-Technology Co., Ltd..
Test method: detect and assessment technique specification by Ministry of Public Health function of health food: rat conforms after 3d, feed and raise basal feed 5d, be then divided at random 4 groups, be i.e. three dosage groups (0.1,0.2,0.6g/kgBW), a control group. Tested material is prepared with sterilized water, and per os gives once a day, and gavage was measured after 34 days continuously, and mouse stomach volume is that 0.1mL/10g mouse is heavy. Blank group replaces tested material with sterilized water, and every day, gavage volume was identical with tested material group, and each dosage group all gives basal feed.
From table 1, the initial weight of each dosage treated animal, mid-term are heavy, end is heavy and weightening finish and control group relatively without significant difference (P > 0.05), illustrate that sea cucumber lycopene tea polyphenol tablet has no significant effect the body weight of mouse under this experiment condition.
The impact of table 1 sea cucumber lycopene tea polyphenol tablet on Mouse Weight
Note: each dosage group and control group comparison, P > 0.05.
2. lycopene tea polyphenol tablet is removed the ability of free radical
Sea cucumber lycopene tea polyphenol tablet prepared by sample: embodiment 2.
Animal used as test: 48 of small white mouses, be divided into 4 groups, 12 every group, body weight 20-22g.
Test method: by the method improvement FeSO of Smirnoff etc.4+H2O2Produce OH, survey A with OH oxidation salicylic acid products therefrom510, with the clearance rate of (control group-dosing group/control group) × 100% calculating OH.
Result of the test: experimental result is in table 2
The scavenging action of table 2 lycopene tea polyphenol tablet to OH
Note: each dosage group and control group comparison, P < 0.01.
From table 2, the equal significant difference of the test group of each dosage and control group (P < 0.01), illustrates that sea cucumber lycopene tea polyphenol tablet has remarkable impact to the removing of free radical under this experiment condition; And dosage just has certain removing ability at 0.2g/kg to OH, illustrate that lycopene tea polyphenol tablet has stronger scavenging action to OH. Between the dosage of lycopene sheet and clearance rate, there is good dose-effect relationship.
3. the antioxidation in vitro of lycopene and Tea Polyphenols independent role test
Sea cucumber lycopene tea polyphenol tablet prepared by sample: embodiment 1, sea cucumber lycopene sheet prepared by comparative example 1, sea cucumber tea polyphenol tablet prepared by comparative example 2, lycopene or tea polyphenol tablet hardness that comparative example 1,2 is made are poor, edge fragmentation, fall slag.
Animal used as test: 30 of small white mouses, are divided into 3 groups, 10 every group.
Table 3 lycopene is or/and the scavenging action of Tea Polyphenols to OH
Note: comparative example group and the comparison of embodiment group, P < 0.01.
From table 3, under this experiment condition, sea cucumber lycopene is removed the ability of free radical and is had significant difference (P < 0.01) with using separately lycopene or the Tea Polyphenols clearance rate of 2 times of ratios in conjunction with tea polyphenol tablet, under the condition of same dose, the inhibiting rate that lycopene and Tea Polyphenols are used in conjunction with is the two 2-5 times of using separately oxidation resistance, and the removing free radical ability of visible composite antioxidant is obviously better than single antioxidant.
4. the impact of sea cucumber lycopene tea polyphenol tablet on mouse cell immunologic function
Sea cucumber lycopene tea polyphenol tablet prepared by sample: embodiment 1.
Animal used as test: 48 of small white mouses, be divided into 4 groups, 12 every group, body weight 20-22g.
Test method: get sheep blood, physiological saline washing 3 times, every mouse is through lumbar injection 2%(v/v, prepare with physiological saline) hematocrit SRBC (2000r/min, 10min) 0.2mL, after sensitization 4 days, measure left back sufficient sole of the foot portion thickness, same Site Determination three times, averages. Then measuring position hypodermic injection 20%(v/v, preparing with physiological saline) hematocrit SRBC20 μ L, within latter 24 hours, measure left back sufficient sole of the foot portion thickness in injection, represent the degree of DTH with the difference of sufficient sole of the foot thickness before and after attacking. The difference of given the test agent group is significantly higher than the difference of control group, can judge this result of the test positive.
The impact of table 4 sea cucumber lycopene tea polyphenol tablet on mouse delayed allergy (DTH)
Note: * representative and 0g/kgBW group relatively there were significant differences property.
From table 4, per os gave the sea cucumber lycopene tea polyphenol tablet of mouse various dose after 34 days, 0.2g/kgBW group compares with 0g/kgBW group, there were significant differences for mouse swelling degree of the paw (P < 0.05), 0.6g/kgBW group compares with 0g/kgBW group, and there were significant differences for mouse swelling degree of the paw (P < 0.05) is that sea cucumber lycopene tea polyphenol tablet can improve mouse swelling degree of the paw in 0.2g/kgBW, 0.6g/kgBW group.

Claims (3)

1. a preparation method for sea cucumber lycopene tea polyphenol tablet, by the raw material of following weight proportion, makes in accordance with the following steps:
Content is lycopene powder 14-17 part of 6%, tea polyphenol powder 5-7 part that content is 80%, holothurian freeze-dried powder 45-55 part, microcrystal cellulose powder 30-35 part, sodium carboxymethyl starch 5-8 part, dolomol 0-1 part, coating powder 2-4 part;
1) raw material preparation: fresh sea cucumber gill and rinse well with clear water after carry out high temperature blanching, temperature is at 65 ~ 70 DEG C, time is no more than 6 minutes, then steeps and sends out, and after 24 hours, takes out and carries out vacuum freeze drying, fresh apostichopus japonicus selenka is chilled to rapidly to-40 DEG C in freeze-drying cabin, under vacuum state, by regulating temperature and pressure, progressively heat up and make ice directly become steam, time is 50 hours, obtains freeze-drying sea cucumber; After the coarse crushing of freeze-drying sea cucumber, cross the Universalpulverizer of 80 mesh sieves and pulverize, obtain holothurian freeze-dried powder; Lycopene powder, tea polyphenol powder, microcrystal cellulose powder, sodium carboxymethyl starch are crossed respectively 80 mesh sieves;
2) mix: holothurian freeze-dried powder, lycopene powder, tea polyphenol powder, microcrystal cellulose powder, sodium carboxymethyl starch are placed in to three-dimensional motion mixer mixing 20min, obtain the mixed powder of color and luster uniformity;
3) granulation, dry, whole grain: mixed powder is poured in agitated kettle, in mixed powder, added the ethanolic solution of concentration 20% to utilize wet mixing pelletizer high-speed stirred to mix wet softwood processed, obtain wet granular; Wet granular enters whole grain in pelletizing machine, makes granular size more even, then it is dry that wet granular is put into HighefficientFluidbeddrier, and temperature is 55-65 DEG C, after dry materials, takes out and obtains dry particle;
4) dry particle layering: dry particle is poured in shaking screen and shaken layering, and the superiors are for being greater than 20 order particles, and middle level is 20-40 order particle, and orlop is for being less than 40 object particles; Collect 20-40 order particle for subsequent use;
5) compressing tablet: dry 20-40 order particle, dolomol are placed in to three-dimensional motion mixer mixing 5min, obtain hybrid particles; Hybrid particles is put into rotary tablet machine compressing tablet, and trimmer is heavily 0.6g/ sheet, compressing tablet, and remove residual, useless sheet, obtain plain sheet;
6) preparation of coating solution: get 95% edible alcohol, adding purified water, to be configured to concentration be 70% ethanolic solution, pouring electrical heating into stirs in heat insulation tank, getting coating powder, slowly to add concentration be in 70% ethanolic solution, cover lid, stirs 1 hour, stirs, be configured to 8% coating solution, for subsequent use;
7) film coating: start high-efficiency coating machine, make the temperature in coating pan reach 45-50 DEG C, pour the plain sheet weighing up into coating drum after negative pressure and temperature stabilization; The coating solution preparing is poured in heat insulation tank, and preheating 5 minutes, opens spraying system, regulates atomizing pressure at 0.15MPa, and spray gun pressure, at 0.8 ~ 1.0MPa, starts main frame in starting peristaltic pump, and homogenate is carried out in the uninterrupted running of cylinder is heated evenly label; Adjust rotating speed and the slurry adjuster of peristaltic pump, use spray gun even spraying in the plain sheet surface of rotating, 55-65 DEG C of heated-air drying; After dressing completes, stop whitewashing, close hot blast, treat that outward appearance is bright and clean, color and luster is even, after label is cooling, closes homogenate and air draft, obtains qualified coating tablet, is to be sea cucumber lycopene tea polyphenol tablet.
2. the preparation method of a kind of sea cucumber lycopene tea polyphenol tablet according to claim 1, is characterized in that described coating powder is hydroxypropyl methylcellulose or glyceryl triacetate.
3. the preparation method of a kind of sea cucumber lycopene tea polyphenol tablet according to claim 1, the lycopene powder described in it is characterized in that is produced by natural microbial fermentation method.
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CN102302614A (en) * 2011-09-28 2012-01-04 大连海晏堂生物有限公司 Compound sea-cucumber tea-polyphenol capsules and preparation method thereof
CN102885305A (en) * 2012-10-12 2013-01-23 中科乐仁（北京）科技发展有限公司 Health food composition for enhancing immunity and preparation method thereof

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CN101810339A (en) * 2010-03-25 2010-08-25 内蒙古宇航人高技术产业有限责任公司 Composite type antioxidant and edible soft capsule
CN102302614A (en) * 2011-09-28 2012-01-04 大连海晏堂生物有限公司 Compound sea-cucumber tea-polyphenol capsules and preparation method thereof
CN102885305A (en) * 2012-10-12 2013-01-23 中科乐仁（北京）科技发展有限公司 Health food composition for enhancing immunity and preparation method thereof

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