CN104381664A - Pig feed for promoting intestinal development of piglets and application of pig feed - Google Patents

Abstract

The invention discloses a pig feed for promoting intestinal development of piglets and its application. The invention fully considers the digestive physiological characteristics of piglets and the nutritional needs of intestinal development through a rational and scientific formula, and adds whey powder, sucrose, glucose and large Soybean oil and other ingredients not only improve fitness and digestibility, but also provide sufficient energy substances for intestinal growth, and relieve insufficient energy supply during intestinal stress. Considering the use of functional amino acids to promote intestinal growth, among which proline provides precursors for polyamine synthesis in piglet intestines, which can promote intestinal maturation and early weaning age of piglets.

Description

A kind of pig feed that promotes intestinal tract development of piglets and its application

technical field

The invention relates to the application field of feed additives, in particular to a pig feed for promoting intestinal tract development of piglets and its application.

Background technique

Intestinal growth is the core of piglet growth and development and the basis for rapid growth. The intestine is the place where the body digests and absorbs nutrients, and it also has an important defense function. Poor appetite, digestive disorders, diarrhea, and slow growth of piglets caused by weaning have always been a problem that plagues the pig industry. Due to the insufficient intestinal development of piglets, early weaning can easily lead to great changes in the morphology, structure and function of the small intestinal mucosa of piglets, inhibiting the full development of growth potential, which is the biggest technical obstacle to implementing early weaning.

Nutrition is the most effective way to regulate the repair of intestinal damage. Researchers at home and abroad have done a lot of research to improve the intestinal environment of piglets and enhance the body's immune function by adding enzyme preparations, acidifiers, oligosaccharides and antibacterial drugs and other nutritional regulation methods. For example, adding an acidifier to the weaning ration can degrade the pH value of the gastrointestinal tract and regulate the gastrointestinal flora, which can not only reduce the incidence of diarrhea in piglets, but also increase the daily gain, feed intake, and feed intake of weaned piglets. The conversion rate can effectively relieve weaning stress; adding organic selenium, vitamin E, plant extracts and other ingredients can help improve the immunity of weaned piglets; adding electrolyte balancers such as sodium bicarbonate can help relieve weaning stress.

The above regulation to relieve weaning stress mainly focuses on regulating the gastrointestinal flora and improving the immune function of the body, but less consideration is given to the immature digestive tract of early weaned piglets, that is, the internal cause of intestinal damage. The maturation status of the gut itself may be a decisive factor for the extent of gut injury in piglets during the acute phase of early weaning. By promoting the early development and maturation of piglet intestinal tract, it will be a nutritional regulation technology that can effectively promote the repair of intestinal mucosal damage and develop growth potential.

Contents of the invention

The purpose of the present invention is to provide a pig feed for promoting intestinal growth of piglets. The feed fully considers the digestive physiological characteristics of piglets and the nutritional needs of intestinal development, and adds whey powder, sucrose, glucose and soybean oil to provide intestinal growth. Sufficient energy substances, while using functional amino acids to promote intestinal growth, fully promote early intestinal maturation to slow down intestinal damage caused by weaning, and can advance the weaning age of piglets to 14 days.

Another object of the present invention is the application of a pig feed for promoting intestinal development of piglets in the preparation of preparations for repairing intestinal tracts of piglets.

In order to achieve the above object, the present invention takes the following technical measures:

A kind of pig feed that promotes intestinal tract development of piglets, its formula is as follows:

The components of the premix are (parts by weight): retinol, 0.005-0.01; vitamin D3, 0.0004-0.001; vitamin E, 0.1-0.2; vitamin _K3 , 0.02-0.05; 0.0005; riboflavin, 0.01-0.05; niacin, 0.2-0.5; pantothenic acid, 0.05-0.2; choline chloride, 4-8; 0.05; Biotin, 0.0005-0.002; ZnSO ₄ 7H ₂ O, 1-4; MnSO ₄ 5H ₂ O, 0.5-2; Iron (FeSO ₄ H ₂ O), 1-4; Copper CuSO ₄ 5H ₂ O, 0.5-2; KI, 0.005-0.01; Na ₂ SeO ₃ ·5H ₂ O, 0.002-0.01; Carrier, 60-95.

The acidulant and antioxidant, currently commercially available acidulant and antioxidant for feed can be used in the present invention.

The carrier is one or a mixture of medical stone, defatted rice bran, secondary powder, rice husk powder and zeolite powder.

A kind of pig feed that promotes intestinal tract development of piglets, its formula is as follows (best value):

The premix components are (parts by weight): retinol, 0.0076; vitamin D3, 0.0006; vitamin E, 0.16; vitamin K3, 0.03; vitamin _B12 , 0.0002; 0.3; pantothenic acid, 0.12; choline chloride, 6; folic acid, _{0.003 ;} vitamin _B1 , 0.015; vitamin B6, 0.03 _; biotin, 0.001; FeSO ₄ ·H ₂ O, 2.52; CuSO ₄ ·5H ₂ O, 1; KI, 0.006; Na ₂ SeO ₃ ·5H ₂ O, 0.008; Support, 85.2;

The carrier is prepared by mixing medical stone and defatted rice bran in a mass ratio of 7:3.

Compared with the prior art, the present invention has the following advantages:

1. The formula of the present invention is reasonable and scientific, fully considering the digestive physiological characteristics of piglets and the nutritional needs of intestinal development, adding whey powder, sucrose, glucose and soybean oil not only improves fitness and digestibility, but also provides sufficient nutrients for intestinal growth Energy substance, relieves insufficient energy supply during intestinal stress.

2. The present invention starts from the internal cause of intestinal injury and considers promoting the early maturation of the intestinal tract, using functional amino acids to promote intestinal growth, wherein proline provides the precursor of polyamine synthesis in the intestinal tract of piglets, which can promote intestinal maturation, Early weaning age of piglets.

3. From the perspective of growth performance and intestinal development and function, feeding the feed under this formula technology for 14 days can significantly promote the proliferation and differentiation of intestinal mucosal cells of 14-day-old piglets, significantly promote the growth of piglets, reduce diarrhea, and slow down weaning stress Injury (see Figure 1 and Figure 2); feeding the feed under this formula technology for 18 days, the intestinal structure and function of 14-day-old piglets 7 days after weaning were not significantly different from those of suckling piglets of the same age.

Description of drawings

Figure 1 is a schematic diagram of the comparison of the effects of the formula described in Example 1 of the present invention and the commercially available piglet creep feed of the same price on the growth performance of piglets.

Fig. 2 is a schematic diagram showing the comparison of the effects of the formula described in Example 1 of the present invention and the commercially available piglet creep feed of the same price on the proliferation of piglet small intestinal mucosal cells.

Fig. 3 is a schematic diagram of the comparison of the effects of the formula described in Example 1 of the present invention and the commercially available piglet creep feed of the same price on the expression of tight junction protein in piglet jejunum.

Fig. 4 is a schematic diagram showing the comparison of the growth performance of piglets fed the formula described in Example 1 of the present invention at 7 days after weaning at the age of 14 and the growth performance of piglets fed with commercially available creep feed at the same price at the age of 21.

Detailed ways

The technical solutions described in the embodiments of the present invention, unless otherwise specified, are conventional techniques in the art, and the raw materials are all purchased from commercial channels.

Example 1:

A kind of pig feed that promotes intestinal tract development of piglets, its formula is as follows:

Described acidulant is the benzoic acid that DSM China Co., Ltd. produces, 99.5% pure.

The antioxidant is Danquiline No. 2 produced by Jiangsu Zhongdan Group Co., Ltd., and the main component is ethoxyquinoline.

The components of the premix are (by weight): retinol, 0.0076; vitamin D3, 0.0006; vitamin E, 0.16; vitamin K3, 0.03; vitamin _B12 , 0.0002; riboflavin, 0.04; Pantothenic acid, 0.3; pantothenic acid, _0.12 ; choline chloride _, 6; folic acid, 0.003; vitamin B1, 0.015; vitamin _B6 , 0.03; biotin, _0.001 ; 0.9586; FeSO ₄ ·H ₂ O, 2.52; CuSO ₄ ·5H ₂ O, 1; KI, 0.006; Na ₂ SeO ₃ ·5H ₂ O, 0.008; carrier (70% by weight of medical stone and 30% by weight of defatted rice bran), 85.2

The preparation method of the pig feed for promoting intestinal tract development of piglets, the steps are:

A. First crush the puffed corn and fermented soybean meal, and pass through a 1.0mm sieve;

B. Soybean oil and puffed corn are fully mixed evenly, and then mixed evenly with other raw materials to obtain powder;

C. Granulate the powder obtained by step polymerization B at 60-70°C to obtain pellets;

D. Mix the powder obtained from Step Polymerization B with the granules obtained from Step Polymerization C at a ratio of 7:3, which is used in the following examples.

Example 2:

An application of a pig feed for promoting intestinal development of piglets in the preparation of preparations for repairing intestinal tracts of piglets, the application process is as follows:

Select 16 piglets from 4 litters, pair them into 2 groups according to the principle of similar litter and body weight, start supplementing the feed described in Example 1 from the age of 3 days of piglets, and the control group eats certain commercially available piglets with the same price. All were fed ad libitum. The piglets were weaned at the age of 14 days, slaughtered and sampled on the 3rd day after weaning, and the growth performance and intestinal structure and function of the test pigs were detected.

The growth performance of the piglets is shown in Figure 1. The birth weights of the test group and the control group were 1.32±0.21kg and 1.32±0.24kg respectively. When eating different feeds until the age of 17 days, the body weights were 4.81kg and 5.37kg respectively. The average final weight of the test group It was 0.56kg higher than the control group, and the average daily gain was 0.033kg/d higher.

The structure of the small intestine villi of piglets is shown in Table 1. The height of the jejunum and ileum villi of the piglets fed the feed described in Example 1 was significantly higher than that of the commercially available piglet creep feed of the same price, and the depth of jejunal crypts was significantly reduced.

The expression of tight junction proteins in the jejunum of piglets is shown in Figure 3. The expression levels of tight junction proteins ZO-1, Occludin, Claudin3 and Claudin1 in piglets jejunum fed the feed described in Example 1 were significantly higher than those of piglets with the same price as the commercially available creep feed.

It can be seen that the formula described in Example 1 of the present invention can significantly promote the proliferation of intestinal mucosal cells of piglets, promote the maturation of the intestinal tract, promote the expression of tight junction proteins, improve the morphology and structure of the intestinal tract, and promote the repair of intestinal damage.

Table 1 The villus structure of piglet small intestine

Example 3:

An application of a pig feed for promoting intestinal development of piglets in the preparation of preparations for repairing intestinal tracts of piglets, the application process is as follows:

160 piglets were selected from 20 litters and divided into two groups according to the principle of same litter and similar body weight.

The piglets in the control group began to freely eat a commercially available creep feed for piglets at the same price from the age of 3 days, and continued until the age of 21 days;

The piglets in the test group began to supplement the feed described in Example 1 from the age of 3 days, and had free access to food until 7 days after weaning at the age of 14 days (21 days of age).

At the age of 21 days, the growth performance was detected, and 8 pigs were slaughtered and sampled in the control group and the experimental group respectively, and the intestinal structure and function were detected.

The growth performance of piglets is shown in Figure 4. The piglets fed on the feed described in Example 1 were weaned at the age of 14 days. At the age of 21 days, the average body weight was 5.87kg, and the daily gain was 0.270kg/d. The average body weight of the weanling piglets fed with the same diet was 5.89kg and the daily gain was 0.271kg/d at the age of 21 days, and the difference was not significant. It is suggested that the weaning age of piglets can be advanced to 14 days under the condition of ensuring the normal growth performance of piglets.

Claims (3)

1. A kind of pig feed that promotes piglet intestinal tract development, and its formula is as follows: The components of the premix are, by weight: retinol, 0.005-0.01; vitamin D3, 0.0004-0.001; vitamin E, 0.1-0.2; vitamin K3, 0.02-0.05; vitamin _B12 , 0.0001- 0.0005; riboflavin, 0.01-0.05; niacin, 0.2-0.5; pantothenic acid, 0.05-0.2; choline chloride, 4-8; 0.05; Biotin, 0.0005-0.002; ZnSO ₄ 7H ₂ O, 1-4; MnSO ₄ 5H ₂ O, 0.5-2; Iron (FeSO ₄ H ₂ O), 1-4; Copper CuSO ₄ 5H ₂ O, 0.5-2; KI, 0.005-0.01; Na ₂ SeO ₃ 5H ₂ O, 0.002-0.01; Carrier, 60-95; Described acidulant and antioxidant, currently commercially available acidulant and antioxidant for feed can be used; The carrier is one or a mixture of medical stone, defatted rice bran, secondary powder, rice husk powder and zeolite powder. 2. The pig feed according to claim 1, characterized in that: The premix components are: retinol, 0.0076; vitamin D3, 0.0006; vitamin E, 0.16; vitamin K3, 0.03; vitamin _B12 , 0.0002; riboflavin, 0.04; 0.12; Choline chloride, 6; _Folic acid, 0.003; Vitamin B1, 0.015; Vitamin B6, 0.03; Biotin, _0.001 ; ZnSO ₄ ·7H ₂ O, _3.6 ; ₂ O, 2.52; CuSO ₄ ·5H ₂ O, 1; KI, 0.006; Na ₂ SeO ₃ ·5H ₂ O, 0.008; Support, 85.2; The carrier is prepared by mixing medical stone and defatted rice bran in a mass ratio of 7:3. 3. the application of the feed described in claim 1 in the preparation promoting piglet intestinal development feed.