CN104351219B - A kind of compound avilamycin preparation for aquaculture and its preparation method and application - Google Patents
A kind of compound avilamycin preparation for aquaculture and its preparation method and application Download PDFInfo
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- CN104351219B CN104351219B CN201410594605.8A CN201410594605A CN104351219B CN 104351219 B CN104351219 B CN 104351219B CN 201410594605 A CN201410594605 A CN 201410594605A CN 104351219 B CN104351219 B CN 104351219B
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- CXEGAUYXQAKHKJ-NSBHKLITSA-N emamectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](NC)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 CXEGAUYXQAKHKJ-NSBHKLITSA-N 0.000 description 12
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- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
The present invention provides a kind of compound avilamycin preparation for aquaculture and its preparation method and application, and compound avilamycin preparation is made up of the component of following weight percentage ratio: abamectin benzoate 2.5～3.5%, Tulathromycin 2～4%, plug draw rhzomorph 3～6%, agriculture breast 0206-B 15～20%, azone 3～5%, dehydrated alcohol 40～60% and dimethylbenzene 25～40%.Present invention can apply to the multiple parasite of killing aquatic animal and antibacterial, virus, between abamectin benzoate, Tulathromycin and the three kinds of active ingredients of Sai La rhzomorph, there is synergistic function, drug effect is high, consumption is few, poison little to environment and animal, and it is not likely to produce drug resistance, there is the advantages such as preparation method is simple, insecticidal range is wide.
Description
Technical field
The invention belongs to field of veterinary, relate to a kind of avilamycin preparation, be specifically related to a kind of compound avilamycin preparation for aquaculture and its preparation method and application.
Background technology
Currently, due to the generation of the disease that the parasite of aquatic animal and antibacterial, virus cause, very big economic loss is caused to culture fishery.The parasites such as China Sao, anchor head Sao, dactylogyrider, little melonworm are aquaculture common causative, very harmful.nullIn fisheries drug insecticide，Dichlorvos、Owing to there is poor stability in the medicines such as malachite green oxalate、Contaminated environment is eliminated with endangering human health，Though there being vegetalitas fish insect killing agent in the preventing and treating of aquatic animal disease，But existing makes consumption big，Take effect slow，Killing effect is not thorough，Relatively costly，The shortcomings such as function singleness，Therefore，The current overwhelming majority still uses tradition organophosphor、Polyesters insecticide，Due to Pesticidal and sterilizing function singleness，When insect pest and bacterial disease occur simultaneously，Need to use a large amount of parasite killing and Bactericidal medicine，These substance toxicity are big，Poorly water-soluble，Life-time service drug resistance strengthens，Cause dosage more with more many vicious cycle，These materials are not degradable in the environment simultaneously，Severe contamination breeding environment，And some material also can cause biological concentration，Directly jeopardize the food safety of the mankind and healthy，Have influence on the sound development of China's aquatic products industry.
Summary of the invention
It is an object of the invention to, for above-mentioned the deficiencies in the prior art, a kind of compound avilamycin preparation for aquaculture is provided, to aquatic animal parasite parasite killing and sterilizing scope is wide, drug effect is high, consumption is few and poisons little to environment and animal, prawn, the Eriocheir sinensis pool and the Chinese Sao of fish pond generation, anchor head Sao, dactylogyrider, little melonworm etc. have effect of well killing, fish, shrimp, the Eriocheir sinensis pool are occurred bacterial disease also to have good prevention effect by compound avilamycin preparation of the present invention, additionally provide the preparation method and application of compound avilamycin preparation of the present invention simultaneously.
For achieving the above object, the present invention adopts the technical scheme that, a kind of compound avilamycin preparation for aquaculture, is made up of the component of following weight percentage ratio: emamectin-benzoate 2.5～3.5%, Tulathromycin 2～4%, plug draw rhzomorph 3～6%, agriculture breast 0206-B15～20%, azone 3～5%, dehydrated alcohol 40～60% and dimethylbenzene 25～40%.
Above-mentioned compound avilamycin preparation, it is preferable that the component composition of following weight percentage ratio: emamectin-benzoate 2.5%, Tulathromycin 3%, plug draw rhzomorph 5%, agriculture breast 0206-B11%, azone 3.5%, dehydrated alcohol 45% and dimethylbenzene 30%.
The present invention is for the compound avilamycin preparation of aquaculture, compound basis and each component are characterized in that: invention formulation active component is emamectin-benzoate, Tulathromycin and Sai La rhzomorph, Pesticidal and sterilizing economic benefits and social benefits are unified, and killing effect during relative to one-component effect is more rapidly and efficiently, emamectin-benzoate is a kind of safe and efficient environment-friendly pesticide, rhzomorph mixing is drawn to use with efficient sterilizing insecticide Tulathromycin and plug, there is good synergistic function, there is good bactericidal effect simultaneously.Tulathromycin is the Macrolide semisynthetic antibiotics of animal specific, mainly acts on Actinobacillus, mycoplasma, pasteurellosis bacillus, secondary haemophilus etc., has that consumption is few, a many merits such as single administration, low-residual and animal specific.Azone in formula can soften the epidermis of polypide, has good permeability, improves the insecticidal effect of this formula.Several Main Ingredients and Appearances of this formula are all that low toxicity is efficient, and therefore that aquaculture is dynamic is all safe, it is possible to use at shrimp Eriocheir sinensis culture pond.On market, due to toxicity relatively greatly, prawn Eriocheir sinensis is dangerous, uses and is very limited for some like product.
A kind of preparation method of the above-mentioned compound avilamycin preparation for aquaculture, step is as follows:
1) each raw material components is weighed by proportioning；
2) emamectin-benzoate is added in dehydrated alcohol, fully dissolve, standby；
3) Tulathromycin and Sai La rhzomorph are dissolved in dimethylbenzene, are subsequently adding step 2) in solution, mix homogeneously, sequentially add agriculture breast 0206-B, azone, at 25～30 DEG C, stir 20min, obtain a kind of light yellow clear liquid, be the present invention compound avilamycin preparation for aquaculture.
The application of the above-mentioned compound avilamycin preparation for aquaculture: the present invention is for the compound avilamycin preparation of aquaculture, the parasite that aquatic animal is occurred has effect of well killing, and the killing of Chinese Sao, anchor head Sao, dactylogyrider and little melonworm etc. occurred particularly with shrimp, the Eriocheir sinensis pool and fish pond has good effect.Compound avilamycin preparation of the present invention, occurs bacterial disease also to have good prevention effect on fish, shrimp, the Eriocheir sinensis pool.
When the present invention uses for the compound avilamycin preparation of aquaculture, according to using area and pest and disease damage degree determines consumption, uniformly splash in 500～1000 times of full pools of dilute with water.
A kind of compound avilamycin preparation for aquaculture of the present invention, compared with prior art, has an advantage in that:
1) applied widely, can effectively kill the parasites such as shrimp, the Eriocheir sinensis pool and the Chinese Sao of fish pond generation, anchor head Sao, dactylogyrider, little melonworm, some bacterial diseasees also be had good prevention effect, plays the effect of a medicine multiple-effect.
2) Main Ingredients and Appearance of the present invention is all the biological preparation of low toxicity, and insecticide avilamycin and antibacterial Tulathromycin, plug draw rhzomorph mixing use to have synergistic function, and drug effect is high, consumption is few, poison little to environment and animal, and is not likely to produce drug resistance.
3) drug effect is gentle, and good water solubility is uniformly dispersed, efficacy stability, and aquatic animal zest is little, and raw material sources are extensive, and cost is low, and preparation method is simple, easy to use.
Detailed description of the invention
Below in conjunction with example, invention is further described.
The present invention is for the compound avilamycin preparation of aquaculture, primary raw material source and specification, in Table 1.
Table 1 primary raw material source and specification
Embodiment 1
A kind of compound avilamycin preparation for aquaculture, is made up of the component of following weight percentage ratio: abamectin benzoate 2.5%, Tulathromycin 3%, plug draw rhzomorph 5%, agriculture breast 0206-B11%, azone 3.5%, dehydrated alcohol 45% and dimethylbenzene 30%.
Preparation: weigh each raw material components by proportioning；Emamectin-benzoate is added in dehydrated alcohol, fully dissolve, standby；Tulathromycin and Sai La rhzomorph are dissolved in dimethylbenzene, it is subsequently adding in the alcoholic solution of the emamectin-benzoate prepared, mix homogeneously, sequentially add agriculture breast 0206-B, azone, 20min is stirred at 25 DEG C, obtain a kind of light yellow clear liquid, be the compound avilamycin preparation of the embodiment of the present invention 1.
The embodiment of the present invention 1 compound avilamycin preparation, can be used for killing China Sao, treatment gill rot, respond well.
Embodiment 2
A kind of compound avilamycin preparation for aquaculture, is made up of the component of following weight percentage ratio: emamectin-benzoate 3.5%, Tulathromycin 2%, plug draw rhzomorph 3%, agriculture breast 0206-B8%, azone 3.5%, dehydrated alcohol 45% and dimethylbenzene 35%.
Preparation: with embodiment 1.
The embodiment of the present invention 2 compound avilamycin preparation, can be used for killing anchor head Sao, argulus, treatment enteritis disease, erythroderma, respond well.
Embodiment 3
A kind of compound avilamycin preparation for aquaculture, is made up of the component of following weight percentage ratio: abamectin benzoate 3.5%, Tulathromycin 3.5%, plug draw rhzomorph 4%, agriculture breast 0206-B10%, azone 5%, dehydrated alcohol 40% and dimethylbenzene 34%.
Preparation: with embodiment 1.
The embodiment of the present invention 3 compound avilamycin preparation, can be used for killing dactylogyrider, little melonworm, treats hemorrhagic disease, respond well.
(1) present invention tests for the compound avilamycin formulations toxic of aquaculture
1 laboratory animal and packet: Carassius auratus 240 tail, body length 12～15cm, body weight 100～120g, purchased from fish farm.Indoor fishpond raise and train one week after for testing.Being randomly divided into experimental group, matched group and blank group, often group is divided into 4 groups by drug level, and each group chooses Carassius auratus 20 tail.
2 test methods
Test water temperature about 25 DEG C, infusion method, if 0.05,0.10,0.15,0.20ppm, totally 4 drug level.
Experimental group adopts the compound avilamycin preparation of the embodiment of the present invention 1 preparation, what matched group adopted that Hubei Yu Yao company produces can be used for shrimp, the Eriocheir sinensis pool insecticide mixed kill peaceful, indicate consumption identical with the present invention, blank group is not added with medicine.
3 results
Increasing in time under each experimental group different pharmaceutical concentration, Carassius auratus death condition is in Table 2
Carassius auratus mortality rate under table 2 different pharmaceutical concentration
Whole experimentation all carries out under starting aerator situation, from above-mentioned experimental result, blank group occurs without fish kills situation, illustrate that the fish kills situation that purchased fry health and feeding manner science, experimental group and matched group occur extends by drug level change and soak time to cause.All there is not fish kills phenomenon in concentration is lower than 0.10ppm and 72h in experimental group, and when concentration is 0.15ppm, the 72h mortality rate of experimental group is only 5%, uses the Carassius auratus mortality rate of compound avilamycin preparation of the present invention significantly lower than matched group.
(2) aquatic animal insect killing effect test
1 compound avilamycin preparation of the present invention is used for killing Caput Felis domestica Sao effect test
Fish is used in 1.1 tests: Cyprinus carpio 200 tail, the long 20cm of body, body weight 120～150g, purchased from fish farm, is randomly divided into experimental group and matched group 1～3, and often group chooses 50 tails.
1.2 test methods:
Water temperature: 25 DEG C
Drug level: 0.05ppm
Experimental group adopts the compound avilamycin preparation of the embodiment of the present invention 1 preparation, and matched group 1 and 2 is with reference to embodiment 1, and being respectively adopted active component is emamectin-benzoate and Tulathromycin；Emamectin-benzoate and two kinds of avilamycin preparations of Sai La rhzomorph, each effective constituent content proportioning of Pesticidal and sterilizing compositions that matched group 1 and 2 adopts is with embodiment 1, and other components suitably increase and decrease.What matched group 3 adopted that Hubei Yu Yao company produces can be used for shrimp, the Eriocheir sinensis pool insecticide mixed kill peaceful, indicate consumption identical with the present invention.
1.3 results: experimental group and matched group 1～3 kill Caput Felis domestica Sao effect in Table 3.
Table 3 effect test
From table 3, experimental group effect is best, and after medication 12h, Caput Felis domestica Sao killing rate reaches 94%, killing rate 100% after 24h.Matched group 1 and 3 effect is worst, and the insecticidal effect of experimental group is substantially better than matched group.
2 compound avilamycin preparations of the present invention are for treating the effect test of erythroderma
Fish is used in 2.1 tests: Ctenopharyngodon idellus 80 tail, body long 25cm, body weight 200g, purchased from fish farm, is randomly divided into experimental group and matched group 1～3, and often group chooses 20 tails.
2.2 test methods:
Water temperature: 32 DEG C
Drug level: 0.05ppm
Experimental group adopts the compound avilamycin preparation of the embodiment of the present invention 2 preparation, matched group 1 and 2 is with reference to embodiment 2, being respectively adopted active component is emamectin-benzoate and Tulathromycin, emamectin-benzoate and two kinds of compound avilamycin preparations of Sai La rhzomorph, the each effective constituent content proportioning of compound avilamycin preparation that matched group 1 and 2 adopts is with embodiment 2, and other components suitably increase and decrease.Matched group 3 adopts the similar disinfection sanitizer that chinese carp pharmaceutical factory, Shanxi one produces, and indicates consumption identical with the present invention, and whole experiment is all carry out when starting aerator.
2.3 results
Symptom before medication: every tail fish body surface substantially has the red skin symptom of 5%～8%, and fish runs around on sinister errands, and does not eat food.
Symptom during use: after medication 24h, experimental group is altered jumping phenomenon and is substantially alleviated, and it is inconspicuous that matched group alleviates phenomenon；After medication 48h, experimental group is altered jumping phenomenon and is disappeared, and fish starts food, has substantially alleviate though matched group 2 alters jumping phenomenon, but still do not eat food；It is inconspicuous that matched group 1 and 3 alleviates phenomenon；Medication the 5th day, experimental group food recovers normal, and red skin symptom disappears substantially, and matched group matched group 2 just starts food, also has the red skin symptom of part, and matched group 1 and 3 is altered jumping phenomenon and substantially alleviated, and starts food, and red skin symptom alleviates to some extent.Can illustrate that experimental group bactericidal effect is substantially better than matched group by above-mentioned experimental result.
Claims (2)
1. the compound avilamycin preparation for aquaculture, it is characterized in that, be made up of the component of following weight percentage ratio: abamectin benzoate 2.5～3.5%, Tulathromycin 2～4%, plug draw rhzomorph 3～6%, agriculture breast 0206-B15～20%, azone 3～5%, dehydrated alcohol 40～60% and dimethylbenzene 25～40%.
2. the preparation method of the compound avilamycin preparation of a claim 1, it is characterised in that step is as follows:
1) each raw material components is weighed by proportioning；
2) abamectin benzoate is added in dehydrated alcohol, fully dissolve, standby；
3) Tulathromycin and Sai La rhzomorph are dissolved in dimethylbenzene, are subsequently adding step 2) in solution, mix homogeneously, sequentially add agriculture breast 0206-B, azone, at 25～30 DEG C, stir 20min, obtain a kind of light yellow clear liquid, be the present invention compound avilamycin preparation for aquaculture.
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| CN106561671A (en) * | 2016-10-17 | 2017-04-19 | 徐州得铸生物科技有限公司 | Tulathromycin-containing sterilization composition |
| CN107714712B (en) * | 2017-10-10 | 2018-08-10 | 王研 | A kind of flubenzuron composition for preventing anchor head Sao diseases |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1582953A (en) * | 2003-08-22 | 2005-02-23 | 王玉万 | Preparation containing avilamycin, etc. as medicines against parasites for fish |
| CN1947506A (en) * | 2006-05-19 | 2007-04-18 | 东北农业大学 | Method for preparing microemulsion, aqueous emulsion and suspending agent contg. Dola-mycetin and Sala-mycetin |
| CN101309587A (en) * | 2005-11-18 | 2008-11-19 | 凯米诺瓦有限公司 | Oil-in-water formulaion of avermectins |
| CN101933935A (en) * | 2010-06-30 | 2011-01-05 | 洛阳惠中兽药有限公司 | Tulathromycin composition and use thereof in preparation of drugs for treating or preventing bacterial diseases of poultry |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1582953A (en) * | 2003-08-22 | 2005-02-23 | 王玉万 | Preparation containing avilamycin, etc. as medicines against parasites for fish |
| CN101309587A (en) * | 2005-11-18 | 2008-11-19 | 凯米诺瓦有限公司 | Oil-in-water formulaion of avermectins |
| CN1947506A (en) * | 2006-05-19 | 2007-04-18 | 东北农业大学 | Method for preparing microemulsion, aqueous emulsion and suspending agent contg. Dola-mycetin and Sala-mycetin |
| CN101933935A (en) * | 2010-06-30 | 2011-01-05 | 洛阳惠中兽药有限公司 | Tulathromycin composition and use thereof in preparation of drugs for treating or preventing bacterial diseases of poultry |
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